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Yates’ research has focused on applied proteomics, protein biochemistry, mass spectrometry, and informatics. His work led to significant advances in the proteomics field where techniques he and his team developed have become a resource to many researchers in the scientific community. He was the lead inventor of SEQUEST software, which correlates tandem mass spectrometry data to sequences in the database, and developer of the shotgun proteomics technique for protein mixture analyses.
He is the Ernest W. Hahn Professor of Chemical Physiology with a joint appointment in the Department of Molecular and Cellular Neuroscience. Before being appointed as Editor-in-Chief of Journal of Proteome Research, he served as an Associate Editor for Analytical Chemistry.
Some of his recent awards include the Ralph N. Adams Award in Bioanalytical Chemistry in 2015, the American Chemical Society Award in Analytical Chemistry in 2015, and being listed as the #1 on List of Most Influential in Analytical Chemistry according to The Analytical Scientist in 2013.