Discover the Most-Read Biological Chemistry Articles of March 2018

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in March 2018, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of March’s most-read articles: Analytical | Applied  | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical

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ACS Biomaterials Science & Engineering

Au-PLGA Hybrid Nanoparticles with Catalase-Mimicking and near-Infrared Photothermal Activities for Photoacoustic Imaging-Guided Cancer Therapy
ACS Biomater. Sci. Eng., 2018, 4 (3), pp 1083–1091
DOI: 10.1021/acsbiomaterials.7b00901

Cardiac Tissue Engineering on the Nanoscale
ACS Biomater. Sci. Eng., 2018, 4 (3), pp 800–818
DOI: 10.1021/acsbiomaterials.7b00913

Degradation Behavior of Silk Nanoparticles—Enzyme Responsiveness
Open access through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2018, 4 (3), pp 942–951
DOI: 10.1021/acsbiomaterials.7b01021

Injectable Hybrid Poly(ε-caprolactone)-b-poly(ethylene glycol)-b-poly(ε-caprolactone) Porous Microspheres/Alginate Hydrogel Cross-linked by Calcium Gluconate Crystals Deposited in the Pores of Microspheres Improved Skin Wound Healing
ACS Biomater. Sci. Eng., 2018, 4 (3), pp 1029–1036
DOI: 10.1021/acsbiomaterials.7b00860

Isolation and Identification of Proteins Secreted by Cells Cultured within Synthetic Hydrogel-Based Matrices
Open access through ACS Editors’ Choice
ACS Biomater. Sci. Eng., 2018, 4 (3), pp 836–845
DOI: 10.1021/acsbiomaterials.7b00647

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ACS Catalysis

Aluminum-Catalyzed Hydroboration of Alkenes
ACS Catal., 2018, 8 (3), pp 2001–2005
DOI: 10.1021/acscatal.7b04279

Consciously Constructing Heterojunction or Direct Z-Scheme Photocatalysts by Regulating Electron Flow Direction
ACS Catal., 2018, 8 (3), pp 2209–2217
DOI: 10.1021/acscatal.7b04323

Decarboxylative Olefination of Activated Aliphatic Acids Enabled by Dual Organophotoredox/Copper Catalysis
ACS Catal., 2018, 8 (3), pp 1715–1719
DOI: 10.1021/acscatal.7b04281

Liquid-Phase Modeling in Heterogeneous Catalysis
ACS Catal., 2018, 8 (3), pp 2188–2194
DOI: 10.1021/acscatal.7b04367

Mo- and Fe-Modified Ni(OH)2/NiOOH Nanosheets as Highly Active and Stable Electrocatalysts for Oxygen Evolution Reaction
ACS Catal., 2018, 8 (3), pp 2359–2363
DOI: 10.1021/acscatal.7b04226

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ACS Chemical Biology

A Cell-Permeable Stapled Peptide Inhibitor of the Estrogen Receptor/Coactivator Interaction
ACS Chem. Biol., 2018, 13 (3), pp 676–684
DOI: 10.1021/acschembio.7b01016

Augmented Reality in Scientific Publications—Taking the Visualization of 3D Structures to the Next Level
ACS Chem. Biol., 2018, 13 (3), pp 496–499
DOI: 10.1021/acschembio.8b00153

Development of Stabilized Peptide-Based PROTACs against Estrogen Receptor α
ACS Chem. Biol., 2018, 13 (3), pp 628–635
DOI: 10.1021/acschembio.7b00985

Discovery of a 29-Amino-Acid Reactive Abiotic Peptide for Selective Cysteine Arylation
ACS Chem. Biol., 2018, 13 (3), pp 527–532
DOI: 10.1021/acschembio.7b00520

Discovery of Selective RNA-Binding Small Molecules by Affinity-Selection Mass Spectrometry
ACS Chem. Biol., 2018, 13 (3), pp 820–831
DOI: 10.1021/acschembio.7b01013

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ACS Chemical Neuroscience

Alzheimer’s Disease, the “One-Molecule, One-Target” Paradigm, and the Multitarget Directed Ligand Approach
ACS Chem. Neurosci., 2018, 9 (3), pp 401–403
DOI: 10.1021/acschemneuro.8b00069

Call for Papers: Allosteric Modulators of Drug Targets—Special Issue for 2019
ACS Chem. Neurosci., 2018, 9 (3), pp 391–391
DOI: 10.1021/acschemneuro.8b00077

Development of a Positron Emission Tomography Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation
Open access through ACS Editors’ Choice
ACS Chem. Neurosci., 2018, 9 (3), pp 578–586
DOI: 10.1021/acschemneuro.7b00385

Diagnosing and Understanding Angiostrongyliasis, A Zoonotic Cause of Meningitis
ACS Chem. Neurosci., 2018, 9 (3), pp 393–394
DOI: 10.1021/acschemneuro.8b00018

Fluorogenic Detection of Monoamine Neurotransmitters in Live Cells
ACS Chem. Neurosci., 2018, 9 (3), pp 469–474
DOI: 10.1021/acschemneuro.7b00391

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ACS Infectious Diseases

Antibiotic Resistance ABC-F Proteins: Bringing Target Protection into the Limelight
ACS Infect. Dis., 2018, 4 (3), pp 239–246
DOI: 10.1021/acsinfecdis.7b00251

Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii
ACS Infect. Dis., 2018, 4 (3), pp 315–324
DOI: 10.1021/acsinfecdis.7b00183

Bicarbonate Alters Bacterial Susceptibility to Antibiotics by Targeting the Proton Motive Force
ACS Infect. Dis., 2018, 4 (3), pp 382–390
DOI: 10.1021/acsinfecdis.7b00194

Biochemical Basis of APOBEC3 Deoxycytidine Deaminase Activity on Diverse DNA Substrates
ACS Infect. Dis., 2018, 4 (3), pp 224–238
DOI: 10.1021/acsinfecdis.7b00221

Discovery of Potent Benzocycloalkane Derived Diapophytoene Desaturase Inhibitors with an Enhanced Safety Profile for the Treatment of MRSA, VISA, and LRSA Infections
Open access through ACS Editors’ Choice
ACS Infect. Dis., 2018, 4 (3), pp 208–217
DOI: 10.1021/acsinfecdis.7b00259

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ACS Medicinal Chemistry Letters

2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4
ACS Med. Chem. Lett., 2018, 9 (3), pp 215–220
DOI: 10.1021/acsmedchemlett.7b00485

Acyl Sulfonamides NaV1.7 Blockers Useful for the Treatment of Pain
ACS Med. Chem. Lett., 2018, 9 (3), pp 161–162
DOI: 10.1021/acsmedchemlett.8b00038

Allosteric Modulators of Nicotinic Acetylcholine Receptors Useful for the Treatment of Cognitive Impairment
ACS Med. Chem. Lett., 2018, 9 (3), pp 163–164
DOI: 10.1021/acsmedchemlett.8b00039

Azabicyclic Fused Pyrimidine Derivatives Useful for the Treatment of Alzheimer’s Disease
ACS Med. Chem. Lett., 2018, 9 (3), pp 165–166
DOI: 10.1021/acsmedchemlett.8b00043

Data Sets Representative of the Structures and Experimental Properties of FDA-Approved Drugs
ACS Med. Chem. Lett., 2018, 9 (3), pp 204–209
DOI: 10.1021/acsmedchemlett.7b00462

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ACS Synthetic Biology

An Automated Induction Microfluidics System for Synthetic Biology
ACS Synth. Biol., 2018, 7 (3), pp 933–944
DOI: 10.1021/acssynbio.8b00025

Co-Compartmentation of Terpene Biosynthesis and Storage via Synthetic Droplet
ACS Synth. Biol., 2018, 7 (3), pp 774–781
DOI: 10.1021/acssynbio.7b00368

Directed Evolution of Membrane Transport Using Synthetic Selections
ACS Synth. Biol., 2018, 7 (3), pp 789–793
DOI: 10.1021/acssynbio.7b00407

DNA Origami Inside-Out Viruses
ACS Synth. Biol., 2018, 7 (3), pp 767–773
DOI: 10.1021/acssynbio.7b00278

Expanding One-Pot Cell-Free Protein Synthesis and Immobilization for On-Demand Manufacturing of Biomaterials
ACS Synth. Biol., 2018, 7 (3), pp 875–884
DOI: 10.1021/acssynbio.7b00383

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Biochemistry

Ampulexins: A New Family of Peptides in Venom of the Emerald Jewel Wasp, Ampulex compressa
Biochemistry, 2018, 57 (12), pp 1907–1916
DOI: 10.1021/acs.biochem.7b00916 

Conformational Entropy of FK506 Binding to FKBP12 Determined by Nuclear Magnetic Resonance Relaxation and Molecular Dynamics Simulations
Open access through ACS AuthorChoice
Biochemistry, 2018, 57 (9), pp 1451–1461
DOI: 10.1021/acs.biochem.7b01256

Human Oxoguanine Glycosylase 1 Removes Solution Accessible 8-Oxo-7,8-dihydroguanine Lesions from Globally Substituted Nucleosomes Except in the Dyad Region
Biochemistry, 2018, 57 (9), pp 1436–1439
DOI: 10.1021/acs.biochem.7b01125

Improved Analysis of RNA Localization by Spatially Restricted Oxidation of RNA–Protein Complexes
Biochemistry, 2018, 57 (10), pp 1577–1581
DOI: 10.1021/acs.biochem.8b00053

Ligand Binding Pathways and Conformational Transitions of the HIV Protease
Biochemistry, 2018, 57 (9), pp 1533–1541
DOI: 10.1021/acs.biochem.7b01248

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Bioconjugate Chemistry

Bioconjugate Materials in Vaccines and Immunotherapies
Bioconjugate Chem., 2018, 29 (3), pp 571–571
DOI: 10.1021/acs.bioconjchem.8b001

Bioconjugation Approaches to Producing Subunit Vaccines Composed of Protein or Peptide Antigens and Covalently Attached Toll-Like Receptor Ligands
Bioconjugate Chem., 2018, 29 (3), pp 572–586
DOI: 10.1021/acs.bioconjchem.7b00478

Cell Membrane Bioconjugation and Membrane-Derived Nanomaterials for Immunotherapy
Bioconjugate Chem., 2018, 29 (3), pp 624–634
DOI: 10.1021/acs.bioconjchem.7b00669

Cellular Bioparticulates with Therapeutics for Cancer Immunotherapy
Bioconjugate Chem., 2018, 29 (3), pp 702–708
DOI: 10.1021/acs.bioconjchem.7b00619

Covalent Conjugation of Peptide Antigen to Mesoporous Silica Rods to Enhance Cellular Responses
Bioconjugate Chem., 2018, 29 (3), pp 733–741
DOI: 10.1021/acs.bioconjchem.7b00656

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Biomacromolecules

A Self-Targeting, Dual ROS/pH-Responsive Apoferritin Nanocage for Spatiotemporally Controlled Drug Delivery to Breast Cancer
Biomacromolecules, 2018, 19 (3), pp 1026–1036
DOI: 10.1021/acs.biomac.8b00012

Diels–Alder Click-Cross-Linked Hydrogels with Increased Reactivity Enable 3D Cell Encapsulation
Biomacromolecules, 2018, 19 (3), pp 926–935
DOI: 10.1021/acs.biomac.7b01715

Electrospun Poly(lactic acid)-Based Fibrous Nanocomposite Reinforced by Cellulose Nanocrystals: Impact of Fiber Uniaxial Alignment on Microstructure and Mechanical Properties
Biomacromolecules, 2018, 19 (3), pp 1037–1046
DOI: 10.1021/acs.biomac.8b00023

Extending Half Life of H-Ferritin Nanoparticle by Fusing Albumin Binding Domain for Doxorubicin Encapsulation
Biomacromolecules, 2018, 19 (3), pp 773–781
DOI: 10.1021/acs.biomac.7b01545

Gelation, Phase Separation, and Fibril Formation in Aqueous Hydroxypropylmethylcellulose Solutions
Biomacromolecules, 2018, 19 (3), pp 816–824
DOI: 10.1021/acs.biomac.7b01611

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Journal of Agricultural and Food Chemistry

Antioxidant Protection of Nobiletin, 5-Demethylnobiletin, Tangeretin, and 5-Demethyltangeretin from Citrus Peel in Saccharomyces cerevisiae
J. Agric. Food Chem., 2018, 66 (12), pp 3155–3160
DOI: 10.1021/acs.jafc.8b00509

Antioxidants: Differing Meanings in Food Science and Health Science
J. Agric. Food Chem., 2018, 66 (12), pp 3063–3068
DOI: 10.1021/acs.jafc.7b05830

Correction to The Chemical Reaction of Glutathione and trans-2-Hexenal in Grape Juice Media To Form Wine Aroma Precursors: The Impact of pH, Temperature, and Sulfur Dioxide
J. Agric. Food Chem., 2018, 66 (11), pp 3046–3046
DOI: 10.1021/acs.jafc.8b00984

Effect of Abscission Zone Formation on Orange (Citrus sinensis) Fruit/Juice Quality for Trees Affected by Huanglongbing (HLB)
Open access through ACS Editors’ Choice
J. Agric. Food Chem., 2018, 66 (11), pp 2877–2890
DOI: 10.1021/acs.jafc.7b05635

Generation of 2-Furfurylthiol by Carbon–Sulfur Lyase from the Baijiu Yeast Saccharomyces cerevisiae G20
J. Agric. Food Chem., 2018, 66 (9), pp 2114–2120
DOI: 10.1021/acs.jafc.7b06125

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Journal of Chemical Theory and Computation

A GPU-Accelerated Parameter Interpolation Thermodynamic Integration Free Energy Method
J. Chem. Theory Comput., 2018, 14 (3), pp 1564–1582
DOI: 10.1021/acs.jctc.7b01175

Balancing Force Field Protein–Lipid Interactions To Capture Transmembrane Helix–Helix Association
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2018, 14 (3), pp 1706–1715
DOI: 10.1021/acs.jctc.7b00983

Computing the Free Energy without Collective Variables
J. Chem. Theory Comput., 2018, 14 (3), pp 1206–1215
DOI: 10.1021/acs.jctc.7b00916

Fast Dynamic Docking Guided by Adaptive Electrostatic Bias: The MD-Binding Approach
J. Chem. Theory Comput., 2018, 14 (3), pp 1727–1736
DOI: 10.1021/acs.jctc.7b01088

Integrating Multiple Accelerated Molecular Dynamics To Improve Accuracy of Free Energy Calculations
J. Chem. Theory Comput., 2018, 14 (3), pp 1216–1227
DOI: 10.1021/acs.jctc.7b01211

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Journal of Medicinal Chemistry

Causes and Significance of Increased Compound Potency in Cellular or Physiological Contexts
J. Med. Chem., 2018, 61 (5), pp 1767–1773
DOI: 10.1021/acs.jmedchem.7b00762

Design and Syntheses of Highly Potent Teixobactin Analogues against Staphylococcus aureus, Methicillin-Resistant Staphylococcus aureus (MRSA), and Vancomycin-Resistant Enterococci (VRE) in Vitro and in Vivo
J. Med. Chem., 2018, 61 (5), pp 2009–2017
DOI: 10.1021/acs.jmedchem.7b01634

Design, Synthesis, and in Vitro and in Vivo Evaluation of Ouabain Analogues as Potent and Selective Na,K-ATPase α4 Isoform Inhibitors for Male Contraception
Open access through ACS AuthorChoice
J. Med. Chem., 2018, 61 (5), pp 1800–1820
DOI: 10.1021/acs.jmedchem.7b00925

Design, Synthesis, and Structure–Activity Relationship Study of 2-Oxo-3,4-dihydropyrimido[4,5-d]pyrimidines as New Colony Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitors
J. Med. Chem., 2018, 61 (6), pp 2353–2371
DOI: 10.1021/acs.jmedchem.7b01612

Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile
J. Med. Chem., 2018, 61 (5), pp 1785–1799
DOI: 10.1021/acs.jmedchem.7b01690

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Journal of Natural Products

Anti-Influenza Triterpene Saponins from the Bark of Burkea africana
Open access through ACS AuthorChoice
J. Nat. Prod., 2018, 81 (3), pp 515–523
DOI: 10.1021/acs.jnatprod.7b00774

Antiplasmodial Chromanes and Chromenes from the Monotypic Plant Species Koeberlinia spinosa
J. Nat. Prod., 2018, 81 (3), pp 475–483
DOI: 10.1021/acs.jnatprod.7b00579

Improved Dose-Response Relationship of (+)-Discodermolide-Taxol Hybrid Congeners
J. Nat. Prod., 2018, 81 (3), pp 607–615
DOI: 10.1021/acs.jnatprod.8b00111

Marine Invertebrate Natural Products that Target Microtubules
J. Nat. Prod., 2018, 81 (3), pp 691–702
DOI: 10.1021/acs.jnatprod.7b00964

Natural Deep Eutectic Solvents: Properties, Applications, and Perspectives
J. Nat. Prod., 2018, 81 (3), pp 679–690
DOI: 10.1021/acs.jnatprod.7b00945

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The Journal of Physical Chemistry B

Comment on “The Mayonnaise Effect”
J. Phys. Chem. B, 2018, 122 (10), pp 2821–2823
DOI: 10.1021/acs.jpcb.8b01006

Glass-Transition Temperature of the β-Relaxation as the Major Predictive Parameter for Recrystallization of Neat Amorphous Drugs
J. Phys. Chem. B, 2018, 122 (10), pp 2803–2808
DOI: 10.1021/acs.jpcb.7b10105

Hydrogen Bonding Features in Cholinium-Based Protic Ionic Liquids from Molecular Dynamics Simulations
J. Phys. Chem. B, 2018, 122 (9), pp 2635–2645
DOI: 10.1021/acs.jpcb.7b12455

Learning about Biomolecular Solvation from Water in Protein Crystals
J. Phys. Chem. B, 2018, 122 (9), pp 2475–2486
DOI: 10.1021/acs.jpcb.7b09898

Live Cell Microscopy: A Physical Chemistry Approach
Open access through ACS Editors’ Choice
J. Phys. Chem. B, 2018, 122 (12), pp 3023–3036
DOI: 10.1021/acs.jpcb.7b11689

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The Journal of Physical Chemistry Letters

Accelerating Chemical Discovery with Machine Learning: Simulated Evolution of Spin Crossover Complexes with an Artificial Neural Network
Open access through ACS AuthorChoice
J. Phys. Chem. Lett., 2018, 9 (5), pp 1064–1071
DOI: 10.1021/acs.jpclett.8b00170

Designing Realizable and Scalable Techniques for Practical Lithium Sulfur Batteries: A Perspective
J. Phys. Chem. Lett., 2018, 9 (6), pp 1398–1414
DOI: 10.1021/acs.jpclett.7b03165

Electrons, Excitons, and Phonons in Two-Dimensional Hybrid Perovskites: Connecting Structural, Optical, and Electronic Properties
J. Phys. Chem. Lett., 2018, 9 (6), pp 1434–1447
DOI: 10.1021/acs.jpclett.8b00201

Interfacial Modification for High-Efficiency Vapor-Phase-Deposited Perovskite Solar Cells Based on a Metal Oxide Buffer Layer
Open access through ACS Editors’ Choice
J. Phys. Chem. Lett., 2018, 9 (5), pp 1041–1046
DOI: 10.1021/acs.jpclett.7b03361

Multicolor Luminescence Switching and Controllable Thermally Activated Delayed Fluorescence Turn on/Turn off in Carbazole–Quinoxaline–Carbazole Triads
J. Phys. Chem. Lett., 2018, 9 (5), pp 1172–1177
DOI: 10.1021/acs.jpclett.8b00136

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Journal of Proteome Research

A Comparison of Common Mass Spectrometry Approaches for Paleoproteomics
J. Proteome Res., 2018, 17 (3), pp 936–945
DOI: 10.1021/acs.jproteome.7b00703

Comparative Proteomic Analysis of Exosomes and Microvesicles in Human Saliva for Lung Cancer
J. Proteome Res., 2018, 17 (3), pp 1101–1107
DOI: 10.1021/acs.jproteome.7b00770

Filter-Based Protein Digestion (FPD): A Detergent-Free and Scaffold-Based Strategy for TMT Workflows
J. Proteome Res., 2018, 17 (3), pp 1227–1234
DOI: 10.1021/acs.jproteome.7b00840

Glutaredoxin-1 Silencing Induces Cell Senescence via p53/p21/p16 Signaling Axis
Open access through ACS AuthorChoice
J. Proteome Res., 2018, 17 (3), pp 1091–1100
DOI: 10.1021/acs.jproteome.7b00761

Integrity of Glycosylation Processing of a Glycan-Depleted Trimeric HIV-1 Immunogen Targeting Key B-Cell Lineages
J. Proteome Res., 2018, 17 (3), pp 987–999
DOI: 10.1021/acs.jproteome.7b00639

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Molecular Pharmaceutics

Charge Reversible and Mitochondria/Nucleus Dual Target Lipid Hybrid Nanoparticles To Enhance Antitumor Activity of Doxorubicin
Mol. Pharmaceutics, 2018, 15 (3), pp 1296–1308
DOI: 10.1021/acs.molpharmaceut.7b01109

Delivery of Oxytocin to the Brain for the Treatment of Autism Spectrum Disorder by Nasal Application
Mol. Pharmaceutics, 2018, 15 (3), pp 1105–1111
DOI: 10.1021/acs.molpharmaceut.7b00991

Enhancing Efficacy and Stability of an Antiheroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality
Mol. Pharmaceutics, 2018, 15 (3), pp 1062–1072
DOI: 10.1021/acs.molpharmaceut.7b00933

Glucose Responsive Rheological Change and Drug Release from a Novel Worm-like Micelle Gel Formed in Cetyltrimethylammonium Bromide/Phenylboronic Acid/Water System
Mol. Pharmaceutics, 2018, 15 (3), pp 1097–1104
DOI: 10.1021/acs.molpharmaceut.7b00988

Importance of Net Hydrophobicity in the Cellular Uptake of All-Hydrocarbon Stapled Peptides
Mol. Pharmaceutics, 2018, 15 (3), pp 1332–1340
DOI: 10.1021/acs.molpharmaceut.7b01130

 

 

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