There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five […]

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in April 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of April’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical

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A Metal-Free DOTA-Conjugated 18F-Labeled Radiotracer: [18F]DOTA-AMBF3-LLP2A for Imaging VLA-4 Over-Expression in Murine Melanoma with Improved Tumor Uptake and Greatly Enhanced Renal Clearance
Bioconjugate Chem., 2019, 30 (4), pp 1210–1219
DOI: 10.1021/acs.bioconjchem.9b00146

Antibody Delivery for Intracellular Targets: Emergent Therapeutic Potential
Bioconjugate Chem., 2019, 30 (4), pp 1028–1041
DOI: 10.1021/acs.bioconjchem.9b00025

Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells
Open Access Through ACS AuthorChoice
Bioconjugate Chem., 2019, 30 (4), pp 1150–1161
DOI: 10.1021/acs.bioconjchem.9b00087

Dual-Bioorthogonal Molecular Tool: “Click-to-Release” and “Double-Click” Reactivity on Small Molecules and Material Surfaces
Bioconjugate Chem., 2019, 30 (4), pp 1140–1149
DOI: 10.1021/acs.bioconjchem.9b00078

Harnessing Exosomes for the Development of Brain Drug Delivery Systems
Bioconjugate Chem., 2019, 30 (4), pp 994–1005
DOI: 10.1021/acs.bioconjchem.9b00085

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Computational Techniques for Predicting Mechanical Properties of Organic Crystals: A Systematic Evaluation
Mol. Pharmaceutics, 2019, 16 (4), pp 1732–1741
DOI: 10.1021/acs.molpharmaceut.9b00082

Correction to “Polymer-Mediated Drug Supersaturation Controlled by Drug–Polymer Interactions Persisting in an Aqueous Environment”
Mol. Pharmaceutics, 2019, 16 (4), pp 1787–1787
DOI: 10.1021/acs.molpharmaceut.9b00229

Correction to “Potential Eye Drop Based on a Calix[4]arene Nanoassembly for Curcumin Delivery: Enhanced Drug Solubility, Stability, and Anti-Inflammatory Effect
Mol. Pharmaceutics, 2019, 16 (4), pp 1788–1788
DOI: 10.1021/acs.molpharmaceut.9b00299

Impact of Ferroquine on the Solubilization of Artefenomel (OZ439) during in Vitro Lipolysis in Milk and Implications for Oral Combination Therapy for Malaria
Open Access Through ACS AuthorChoice
Mol. Pharmaceutics, 2019, 16 (4), pp 1658–1668
DOI: 10.1021/acs.molpharmaceut.8b01333

Microstructure Formation for Improved Dissolution Performance of Lopinavir Amorphous Solid Dispersions
Mol. Pharmaceutics, 2019, 16 (4), pp 1751–1765
DOI: 10.1021/acs.molpharmaceut.9b00117

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Catalytic Deprotonative α-Formylation of Heteroarenes by an Amide Base Generated in Situ from Tetramethylammonium Fluoride and Tris(trimethylsilyl)amine
This article is part of the Japanese Society for Process Chemistry special issue.
Org. Process Res. Dev., 2019, 23 (4), pp 443–451
DOI: 10.1021/acs.oprd.8b00247

Development of a Synthetic Process for K-8986, an H1-Receptor Antagonist
This article is part of the Japanese Society for Process Chemistry special issue.
Org. Process Res. Dev., 2019, 23 (4), pp 470–476
DOI: 10.1021/acs.oprd.8b00380

Development of an Efficient Manufacturing Process for a Key Intermediate in the Synthesis of Edoxaban
This article is part of the Japanese Society for Process Chemistry special issue.
Org. Process Res. Dev., 2019, 23 (4), pp 524–534
DOI: 10.1021/acs.oprd.8b00413

Development of Asymmetric Transfer Hydrogenation with a Bifunctional Oxo-Tethered Ruthenium Catalyst in Flow for the Synthesis of a Ceramide (d-erythro-CER[NDS])
This article is part of the Japanese Society for Process Chemistry special issue.
Org. Process Res. Dev., 2019, 23 (4), pp 452–461
DOI: 10.1021/acs.oprd.8b00338

Efficient Azacycle Formations Developed in Japanese Pharmaceutical Industries: Elegancy, Logistics, and Training (ELT) “Sandwich” for Process Chemists
This article is part of the Japanese Society for Process Chemistry special issue.
Org. Process Res. Dev., 2019, 23 (4), pp 419–442
DOI: 10.1021/acs.oprd.8b00412

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A Highly Active Catalyst System for Suzuki–Miyaura Coupling of Aryl Chlorides
Organometallics, 2019, 38 (7), pp 1459–1467
DOI: 10.1021/acs.organomet.8b00883

Associative Ligand Exchange and Substrate Activation Reactions by a Zero-Valent Cobalt Tetraisocyanide Complex
Organometallics, 2019, 38 (7), pp 1436–1444
DOI: 10.1021/acs.organomet.8b00777

Dehydrogenative Coupling of Aldehydes with Alcohols Catalyzed by a Nickel Hydride Complex
Organometallics, 2019, 38 (7), pp 1468–1478
DOI: 10.1021/acs.organomet.8b00888

Preparation of Ni(cod)2 Using Light as the Source of Energy
Organometallics, 2019, 38 (7), pp 1413–1416
DOI: 10.1021/acs.organomet.9b00057

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