May 2016 - ACS Axial | ACS Publications

ACS Sensors’ J. Justin Gooding Named Felllow of Australian Academy of Science


ACS Sensors Editor-in-Chief J. Justin Gooding was named a fellow of the Australian Academy of Science this week. Gooding is one of 21 honorees recognized by the organization, each of whom were recognized for making significant and lasting impacts in their scientific disciplines.

The academy praised Gooding for his use of “electrochemistry, synthetic chemistry, interfacial physical chemistry, electron transfer theory, protein biochemistry, and cytochemistry, in order to modify surfaces at the molecular level to enable them to specifically recognise biochemical molecules and to transduce that biochemical information to the end user directly within biological fluids.” They also lauded his work in developing ways to detect bioactive metals and his pursuit of a silicon chip capable of sensing infection.

Learn more about J. Justin Gooding and his work in this video:

ACS Editors’ Choice: Treating “Chemobrain” — and More!

This week: density matrix embedding theory in quantum chemistry, malaria drugs, treating “chemobrain” — and more!

Each and every day, ACS grants free access to a new peer-reviewed research article from one of the Society’s journals. These articles are specially chosen by a team of scientific editors of ACS journals from around the world to highlight the transformative power of chemistry. Access to these articles will remain open to all as a public service.

Check out this week’s picks!

A Practical Guide to Density Matrix Embedding Theory in Quantum Chemistry


J. Chem. Theory Comput., Article ASAP
DOI: 10.1021/acs.jctc.6b00316
Coordination Chemistry of Anticrowns. Synthesis and Structures of Double-Decker Sandwich Complexes of the Three-Mercury Anticrown (o-C6F4Hg)3 with Halide Anions Containing and Not Containing Coordinated Dibromomethane Molecules


Organometallics, Article ASAP
DOI: 10.1021/acs.organomet.6b00231
A Small-Molecule Screening Platform for the Discovery of Inhibitors of Undecaprenyl Diphosphate Synthase


ACS Infect. Dis., Article ASAP
DOI: 10.1021/acsinfecdis.6b00044
Photooxidation of the Antimicrobial, Nonribosomal Peptide Bacitracin A by Singlet Oxygen under Environmentally Relevant Conditions


Environ. Sci. Technol., Article ASAP
DOI: 10.1021/acs.est.6b01131
Impaired Brain Dopamine and Serotonin Release and Uptake in Wistar Rats Following Treatment with Carboplatin


ACS Chem. Neurosci., Article ASAP
DOI: 10.1021/acschemneuro.5b00029
Tetrahydro-2-naphthyl and 2-Indanyl Triazolopyrimidines Targeting Plasmodium falciparum Dihydroorotate Dehydrogenase Display Potent and Selective Antimalarial Activity


J. Med. Chem., Article ASAP
DOI: 10.1021/acs.jmedchem.6b00275
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Celebrate Cancer Research Awareness Month with Journal of Medicinal Chemistry and ACS Medicinal Chemistry Letters


It’s an exciting time to be in cancer research. Advances in both immunotherapy and chemotherapy research are revolutionizing treatment for many cancers and are improving outcomes for many patients. Medicinal chemists are using innovative strategies to improve chemotherapeutic agents in ways that reduce toxic side effects and overcome drug resistance. For example, chemists have refined mechanisms to conjugate small molecule chemotherapeutics to tumor specific antibodies, allowing for targeted delivery of the drug to tumor cells. These antibody-drug conjugates selectively deliver toxic drugs to tumor cells thus reducing the potential for widespread toxicity.

Another important area of drug development for cancer research focuses on inducing protein degradation as a therapeutic strategy. Recent findings that drug-induced protein degradation could be employed as an effective approach to target cancer cells have been promising and compounds have progressed to clinical trials.

Journal of Medicinal Chemistry and ACS Medicinal Chemistry Letters are pioneers in publishing in these rapidly growing areas of cancer research:

In honor of May being Cancer Research Awareness Month, check out some of the recent research appearing in Journal of Medicinal Chemistry and ACS Medicinal Chemistry Letters:

  • Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)
    Med. Chem., 2015, 58 (24), pp 9480–9497
    DOI: 10.1021/acs.jmedchem.5b01346
  • Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR
    ACS Med. Chem. Lett., 2016, 7 (4), pp 351–356
    DOI: 10.1021/acsmedchemlett.6b00005
  • MLN8054 and Alisertib (MLN8237): Discovery of Selective Oral Aurora A Inhibitors
    ACS Med. Chem. Lett., 2015, 6 (6), pp 630–634
    DOI: 10.1021/ml500409n
  • Ado-trastuzumab Emtansine (T-DM1): An Antibody–Drug Conjugate (ADC) for HER2-Positive Breast Cancer
    Med. Chem., 2014, 57 (16), pp 6949–6964
    DOI: 10.1021/jm500766w
  • Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway
    ACS Med. Chem. Lett., 2016, 7 (2), pp 182–187
    DOI: 10.1021/acsmedchemlett.5b00396

C&EN Roundup: Storing Natural Gas, a Nanowire Battery and a Vaccine for Meth

Chemical & Engineering News covers the world of chemistry, from research and education to business and policy. Here’s a sampling of their coverage of research from ACS journals:


New Storage Technique Could Make Natural Gas More Convenient


Sealing natural gas in porous beads with hydrocarbon plugs could allow the fuel to be transported in compact, affordable containers, researchers say. The method allows the gas to be stored and transported easily, without resorting to high pressures or low temperatures to improve its storage density. Improving natural gas’ storage density could help it find favor as a fuel for smaller vehicles.


Nanoparticles Improve Design of Paper Microfluidic Devices


Paper microfluidic devices can be used in low-cost medical tests. The devices use hydrophobic ink or wax printed into channels on paper, which wick fluid through areas design to test for specific features, such as cancer biomarkers. Now researchers are using nanoparticles to increase the wicking rate of the channels, improving flow rate and test reproducibility, two drawbacks that had stymied wider adoption of the devices.


Nanowire Battery Holds Up Over 100,000 Charges


A battery built from manganese-dioxide-coated gold nanowires and a polymethyl methacrylate gel electrolyte has endured being recharged more than 100,000 times and is still going strong, researchers report. Switching from a liquid electrolyte to a gel appears to have been the key, but it is still unclear why the gel extends the battery’s life from between 2,000 and 8,000 charges to more than 100,000. One theory is that the gel plasticizes the manganese-dioxide layer and keeps it from breaking, but more tests are needed.


Researchers Make Progress in Search for Meth Vaccine


A vaccine could someday offer hope to those struggling with methamphetamine addiction by using an immune response to prevent the drug from reaching the brain. In a recent study, mice that were given the vaccine displayed less hyperactivity than non-immunized mice, following exposure to the stimulant. One challenge in developing the vaccine is that methamphetamine molecules are much smaller than those typically targeted by a body’s immune system, though linking the molecule to larger carriers, such as proteins, appears to yield results.


Probe Shines A Light On Multiple Cell Types


Fluorescent molecules capable of bonding to the cells of mammals, fungi and bacteria could make it much easier to study cell structures. The new molecules could replace probes that rely on commercial cell-surface dyes, which tend to be expensive, time-sensitive and less versatile, researchers say. Further experiments will look to determine if the probes can be used to help target drug delivery.


That’s just a small sample of the robust coverage C&EN provides. Get the latest news in your discipline with weekly e-mail updates.

4 Steps to Improving Submission Success for Indian Scientists

In recent years, India has seen substantial growth in its annual output of scientific publications. It quadrupled its research output between 2001 and 2013. The country’s greatest research strengths are in chemistry and materials science. While India has a low density of researchers relative to the size of its population, the number of women entering the research workforce is growing at an unprecedented rate.

Over the last five years, ACS Publications has published more than 48,000 articles from China, India, Korea, and Brazil. More than 7,000— 15% —of those articles were published by authors in India.

India’s scientific output will likely continue to increase. The government announced its annual budget in early 2016, allocating 44.7 billion rupees to the Department of Science and Technology and 18.2 billion rupees to the Department of Biotechnology. These figures represent increases of 17% and 12%, respectively, over the 2015 budget.

More funding leads to more publications. With this surge ahead, it’s more important than ever for researchers in India to produce high-quality, original work that sets them apart. There are four critical steps scientists can take to improve the chances of a peer-reviewed journal accepting their work. Discover these four steps and get critical tips for presenting your research in the best light with the new ACS Publications white paper, “Growing Globally: How Scientists in India Can Share Their Research with the World.”

Cleaning Water With Tiny Motors

Motors are an essential component of some of our largest machines, but motors don’t have to be huge to have a big impact. Scientists are developing new motors that are tiny and soft. They run on things like light, magnetic effects or chemical solutions. And they can serve specific functions — including cleaning up pollution.

Watch a demonstration of a new motor designed by a team of Chinese researchers and built from a low-cost hydrogel. The motor is used to clean organic contaminants, such as pesticides, from water. The motor is propelled by oxygen generated from the reaction it uses to clean the water.

Watch it in action here:

Read the original research in ACS Applied Materials & Interfaces.

A Commentary on Academic Identity Theft

As a chemist, you are trained to focus on lab and environmental safety to protect yourselves, your colleagues, and the consumers of your research. In today’s virtual, networked world, information security is an integral part of this “safety first” outlook. As a scientific scholarly community, it is everyone’s job to protect the data that drives our systems, our research, our communications, and our collaborations. Respected information industry commentator, Rick Anderson, Associate Dean, J. Willard Marriott Library at University of Utah, offers thought-provoking insight into scholarly communication reform.

How Do Libraries and Librarians Benefit from the Figshare Partnership?

In November 2015, ACS Publications announced a new partnership with Figshare to encourage the broad discovery and use of research data and supplemental information (SI).

The ACS Publications-Figshare partnership provides several tangible and immediate benefits to all users of ACS Publications, but what should libraries and librarians be aware of?

  • Figshare now provides greater visibility, accessibility, and discoverability SI. Users will still be able to find and download SI through traditional means, like the ACS Publications website, but now our SI in Figshare can be found through Google, Google Scholar, and other indexing sources. We encourage librarians to include a link to Figshare in their LibGuides or other Chemistry Research Guides to help aid in the discoverability of SI.
  • All SI published through ACS Publications and hosted in Figshare is issued a digital object identifier (DOI). These DOIs allow streamlined citation and discoverability of the SI. In addition for librarians working with researchers and in scholarly communications, these DOIs can partially fulfill funder requirements.
  • Directly built into the Figshare platform is interactive and visualization tools to help users better understand the SI. The tools in Figshare can help aid in the instruction and understanding of aspects of chemistry at the microscopic level. For example, crystallographic files come to life and allow quick viewing and manipulation:
  • Finally, all SI is now freely available through the ACS Publications website and Figshare. We hope that freely available SI will encourage the reuse and advancement of chemistry for all of our global users.

To learn more about the ACS Publications-Figshare partnership, please read our ACS Axial article from February 2016:


ACS Launches Energy Letters

Every year, ACS Publications launches new journals that address specialist topics and emerging or niche science. There is a growing demand for specialist publishing outlets to support the work being done in the scientific community. It is the ACS belief that specialist journals allow the dissemination of more volume and detail than may be appropriate in a mainstream or generalist title, and help to foster collaboration between scientists in the field, creating new potential and furthering the research that is possible.

So far in 2016, there have already been two new additions to the ACS Publications portfolio. ACS Energy Letters will be a rare mid-year launch in acknowledgement of this rapidly changing area of research.

ACS Energy Letters will be a peer-reviewed journal devoted to new scientific advances in all aspects of energy research. The journal will focus on the rapid publication of research in the fields of energy capture, conversion, and storage. Regular topics for inclusion will look at energy materials and light-harvesting assemblies, as well as energy conversion processes, inorganic, organic and hybrid photovoltaics. A range of fuel disciplines will be covered – from solar fuels, photosynthesis and biofuels, to fuel cells, storage batteries and supercapacitors. Submissions will also be welcomed in the fields of plasmonics, OLEDs, and light display systems, as well as tandem devices, piezoelectric, and thermoelectric processes.

ACS Energy Letters will disseminate perspectives from prominent researchers in the field, with reviews on emerging areas of interest, and viewpoints from the scientific community. This exciting new interdisciplinary journal has been designed to appeal to experimentalists, computational and theoretical chemists, and energy device makers who seek to gain insights into new energy advances. The journal will be a valuable addition to library collections and will engage readers and researchers.

Research submissions are being considered now, with the first issue due for publication in July 2016. There will be 6 issues produced this year and 12 issues annually starting in 2017. You can visit the journal website to see ASAP articles published online ahead of print. Or follow us on Twitter @ACSEnergyLett for news and updates.

Once launched, ACS Energy Letters will be added to the All Publications or All Access library subscription packages as a matter of course, so any institutions or companies subscribing at this level will have automatic access. For users with a token package such as ACS Metered Access or ACS Core Plus Package, tokens may be used to provide access to ACS Energy Letters. Alternatively, users can purchase a 6- or 18-month subscription that aligns with their typical calendar year renewal.

If you would like to find out more about this exciting new title, or if you would like to receive library materials to help raise awareness of this new journal within the research community in your institution, visit the library administrator site and download the latest KBART file. If your institution’s research involves energy or the environment, talk with the ACS sales team about ensuring access for your users.

PatentPak, a CAS Solution, Streamlines Chemical Information Searches in Patents

PatentPak saves around half the time needed to find the important chemistry in patents

CAS, a division of the American Chemical Society, now offers PatentPak, a new patent workflow solution. PatentPak is available in both SciFinder® and STN®, and can drastically reduce the time spent searching for chemical information in patents.

Third-party research indicates that the extensive length and complexity of global patents often pose challenges when evaluating these documents. It can also be difficult to find information in local languages for readers. A recent publication by Senger et al suggests that automated approaches miss 38–49% of chemistry in patents.[1]

By leveraging the extensive intellectual analysis of CAS scientists, vital chemistry in patents can now be identified and quickly located. PatentPak makes it possible to:

  • Rapidly track down the specific location of chemical information in patents
  • Instantly and securely access full-text patents from major patent offices
  • Find an equivalent patent in a familiar language.

Research professionals at prestigious commercial, government, and academic institutions around the world, including Eli Lilly and Company, the University of Alabama, and universities in Israel and Turkey, among others, are already benefiting from efficiencies using PatentPak.

“The University of Alabama Libraries selected PatentPak to more quickly access chemical information within the patent literature,” said Vincent F. Scalfani, Ph.D., science and engineering librarian at The University of Alabama. PatentPak will also make patent literature more accessible to new researchers, including undergraduate students.  Incorporating the full-text PDF and indexed chemical structures directly within SciFinder removes many of the barriers associated with discovering and retrieving patent chemical information, streamlining information discovery.

PatentPak has also been recognized by the Software & Information Industry Association (SIIA) for excellence and innovation among the industry’s leading products and services. It is currently a finalist for the prestigious CODiE award in two categories: Best Science & Technology Information Solution and Best Content Curation Platform.

PatentPak provides access to nearly 9 million full-text patents from 31 major patent offices, and coverage continues to grow with new content added daily. The interactive patent chemistry viewer has built-in search functionality that facilitates fast, efficient access to the exact location of information a researcher needs. Key substances in the patent are shown as simple interactive links, allowing quick and easy identification, review, and mark up.

PatentPak was initially introduced with access through SciFinder in 2015, and access in STN was made available in January 2016. Craig Stephens, vice president of sales at CAS, describes the demand for PatentPak:

Intellectual property professionals told us they were eagerly awaiting the addition of PatentPak in STN. As patents continue to grow in volume, length, and complexity, the amount of time patent examiners, analysts, and attorneys are spending hunting through page after page to find a few sentences of interest presents a tremendous opportunity for increased efficiency. By taking users immediately to the location of the key chemical information they need, PatentPak saves hours, enhancing productivity and providing a competitive edge in the race to protect novel inventions.

Time is your most valuable resource. Preserve it with PatentPak.

For more information about PatentPak visit or contact your CAS Account Representative.

1 Senger, S.; Bartek, L.; Papadatos, G.; Gaulton, A.   Managing expectations: assessment of chemistry databases generated by automated extraction of chemical structures from patents. J. Cheminform. [Online] 2015, 7, 1-12.