January 2017 - ACS Axial | ACS Publications
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Watch How Researchers Unraveled the Secret of Water Striders’ Skills

Water striders’ ability to walk on water mystified researchers for generations, but now new research published in Langmuir sheds light on this curious phenomenon. Scientists developed a new understanding of this seemingly gravity-defying talent using a trick of their own — studying the bugs’ leg shadows. The researchers placed a white sheet of paper at the bottom of a lab aquarium housing water striders and installed a light source above the water. The insects’ stick-straight legs cast shadows that were rounded, representing the curvature of the water and the expelled water volume from which the floating force and weight can be calculated, the researchers say. Also, from these measurements, the striders’ slightest shifts in weight and body angle could be detected for the first time. The study offers more than just satisfaction of intellectual curiosity, however.  Researchers say this knowledge could someday by cross-applied to help design robots capable of walking on the water.

Learn more about the science of water striders’ remarkable abilities in this video:

Defending Science in a Skeptical Society

The following is an excerpt from the report “Top 10 Trends Driving Science,” a look at the social, political, and economic forces affecting researchers in 2017.

Scientists have always challenged the public with new ideas, but sometimes it takes a while for a scientific finding to find broad public support. Research shows even trained scientists have to battle a subconscious level of uncertainty when presented with a true yet counter-intuitive statement. But with persistence, even once-unthinkable ideas can gain wide acceptance.

Recently, however, we’ve seen a flurry of intense skepticism around ideas that were once uncontroversial, such as the safety of vaccines and fluoridated water, especially in the U.S. Old fights on subjects such as evolution and climate change seem to have a new intensity. “Unfortunately, many in society do not trust the opinions of scientists in important areas. For example, the notions that vaccines cause autism, or choosing to ignore the impact of human activity on climate change, to name a few. This leads to less enthusiasm for the funding of science,” says Journal of Chemical Information and Modeling Editor-in-Chief Kenneth Merz.

The good news is there’s little evidence to suggest a widespread, catastrophic decline in public trust in science in recent years. Almost 4 –in-5 Americans say science improves their lives. The bad news is that while Americans say they have positive views of science and scientists, they often say they won’t accept certain scientific findings. Many Americans express sharply divergent views from scientists on topics such as climate science, the safety of genetically modified foods and human evolution.

It’s tempting to blame this on a lack of education. Surveys suggest both the public and scientists harbor dim views of U.S. education in science and math. But U.S. primary and secondary science education performs better than many people expect in international science education rankings. Scientists continue to have high regard for post-secondary science education at U.S. institutions. “The U.S. is recognized as a leader at the college and graduate level,” says Norbert Pienta, Editor-in-Chief of the Journal of Chemical Education.

But additional education doesn’t appear to improve matters. In some cases, a high level of education correlates with mistrusting scientists around a particular issue. Political and religious views, however, may impact a person’s views on science, though no one factor is a sure indicator of this.

“On issues such as climate change, many in the world (especially in the U.S.) are choosing to ignore or deny data and verifiable facts in favor of deeply held beliefs of a wishful or magical nature (in the sense that they are not or cannot ultimately be backed up by tangible data). To the degree that public policy is influenced by wishful and magical thinking that is contrary to verifiable facts, we abandon the potential fruit of science to help shape a better world. Don’t get me wrong—I am not talking about here about religion—whose interests are often well-aligned with science. I am talking about willful know-nothingness that evades or denies facts based on a political or social agenda,” said Charles Sanders, Interim Editor of Biochemistry.

While the number of people with a political or religious objection to a scientific finding may be comparatively small, their attacks may exact a disproportionate toll. “Politically motivated ‘attacks’ on science research are taking a toll on the positive public perception of university-performed science research, especially in some scientific disciplines,” says Analytical Chemistry Editor-in-Chief Jonathan Sweedler. “Scientists need to spend their valuable time to ensure the informed dissemination of their scientific results in the media.”

Europeans express high levels of enthusiasm for science as a force for good in the world. But religious concerns about science persist, especially in southern Europe. Almost 4-in-10 European Union citizens say society relies too much on science and not enough on faith.  The same survey finds 60% of EU citizens say the world is changing too quickly and almost three-quarters say they’re concerned about unforeseen side effects of scientific progress.

In China, government support for research funding is strong. A majority of students surveyed express an interest in pursuing a career in science and technology. Research shows the Chinese are among the most likely to accept findings on evolution. Yet alternative medical practices based on tradition continue to flourish there. When it comes to climate change, both China and India lag behind other major carbon-emitting nations regarding awareness and concern about the effects of climate change.

In India, attitudes toward science can be somewhat stratified. More than 1-in-4 Indian citizens are illiterate. These illiterate citizens are much less likely to know basic scientific principles and report high rates of acceptance of folk beliefs than citizens who can read. They are also less likely to feel that science improves their quality of life.

International comparisons on this issue are difficult to make, as no universal survey exists to measure shifting attitudes on a global scale. It would be a mistake to look at some societies as more “scientific” than others. There are no purely evidence-based societies. The particular issues that are controversial may vary from place to place, but the idea that science can be controversial does not. Yet surveys from around the world reveal a healthy regard for science and scientists, even when people struggle with certain scientific findings.

Regardless of the nation, it is important to remember that popular skepticism toward science is not new. What is new is the ability of like-minded deniers to organize online, and to be fueled by those with a vested interest in denying the truth. In the face of these challenges, scientists must do more than just discover the truth. They must be advocates for truth in an increasingly skeptical world.

 

Most-Read Articles of 2016: Multidisciplinary Chemistry Journals

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in 2016, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list for 2016, but rather as an interesting perspective on where the chemistry community allocated their attention over the past year.

Of course, certain factors such as publishing earlier in the year, being featured in a special issue or being made open access may influence which items appeared on this list. To that end, ACS Axial will be publishing monthly updates on the most read chemistry articles of 2017 all year long. Don’t see your favorite papers on the list? Feel free to share your picks in the comments below.

Read more most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Organic/Inorganic | Physical

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Accounts of Chemical Research

Na-Ion Battery Anodes: Materials and Electrochemistry

Acc. Chem. Res., 2016, 49 (2), pp 231–240
DOI: 10.1021/acs.accounts.5b00482

Making and Breaking of Lead Halide Perovskites
(Open Access Through ACS AuthorChoice)
Published as part of the Accounts of Chemical Research special issue “Lead Halide Perovskites for Solar Energy Conversion”.

Acc. Chem. Res., 2016, 49 (2), pp 330–338
DOI: 10.1021/acs.accounts.5b00455

Recent Advances in the Inverted Planar Structure of Perovskite Solar Cells
Published as part of the Accounts of Chemical Research special issue “Lead Halide Perovskites for Solar Energy Conversion”.

Acc. Chem. Res., 2016, 49 (1), pp 155–165
DOI: 10.1021/acs.accounts.5b00404

Rationaxcl Strategies for Efficient Perovskite Solar Cells
Published as part of the Accounts of Chemical Research special issue “Lead Halide Perovskites for Solar Energy Conversion”.

Acc. Chem. Res.
, 2016, 49 (3), pp 562–572
DOI: 10.1021/acs.accounts.5b00444

Metal–Organic Frameworks as Platforms for Functional Materials

Acc. Chem. Res., 2016, 49 (3), pp 483–493
DOI: 10.1021/acs.accounts.5b00530

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ACS Central Science

Catalytic Oxidation of Methane into Methanol over Copper-Exchanged Zeolites with Oxygen at Low Temperature
(Open Access Through ACS AuthorChoice)

ACS Cent. Sci., 2016, 2 (6), pp 424–429
DOI: 10.1021/acscentsci.6b00139

Achieving Gender Balance in the Chemistry Professoriate Is Not Rocket Science
(Open Access Through ACS AuthorChoice)
ACS Cent. Sci., 2016, 2 (4), pp 181–182
DOI: 10.1021/acscentsci.6b00102

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles
(Open Access Through ACS AuthorChoice)

ACS Cent. Sci., 2016, 2 (10), pp 687–701
DOI: 10.1021/acscentsci.6b00086

Synthetic Organic Electrochemistry: An Enabling and Innately Sustainable Method
(Open Access Through ACS AuthorChoice)

ACS Cent. Sci., 2016, 2 (5), pp 302–308
DOI: 10.1021/acscentsci.6b00091

Neural Networks for the Prediction of Organic Chemistry Reactions
(Open Access Through ACS AuthorChoice)

ACS Cent. Sci., 2016, 2 (10), pp 725–732
DOI: 10.1021/acscentsci.6b00219

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ACS Omega

Light-Assisted Solvothermal Chemistry Using Plasmonic Nanoparticles
(Open Access Through ACS AuthorChoice)

ACS Omega, 2016, 1 (1), pp 2–8
DOI: 10.1021/acsomega.6b00019

Humic Acid as a Sensitizer in Highly Stable Dye Solar Cells: Energy from an Abundant Natural Polymer Soil Component
(Open Access Through ACS AuthorChoice)

ACS Omega, 2016, 1 (1), pp 14–18
DOI: 10.1021/acsomega.6b00010

Chemistry, From Alpha to Omega, Open to All
(Open Access Through ACS AuthorChoice)
ACS Omega, 2016, 1 (1), pp 1–1
DOI: 10.1021/acsomega.6b00103

Synthesis of Nanovesicular Glutathione Peroxidase Mimics with a Selenenylsulfide-Bearing Lipid
(Open Access Through ACS AuthorChoice)

ACS Omega, 2016, 1 (1), pp 58–65
DOI: 10.1021/acsomega.6b00046

Converting Light Energy to Chemical Energy: A New Catalytic Approach for Sustainable Environmental Remediation
(Open Access Through ACS AuthorChoice)

ACS Omega, 2016, 1 (1), pp 41–51
DOI: 10.1021/acsomega.6b00076

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Chemical Reviews

Cu and Cu-Based Nanoparticles: Synthesis and Applications in Catalysis
Open Access Through ACS AuthorChoice

Chem. Rev., 2016, 116 (6), pp 3722–3811
DOI: 10.1021/acs.chemrev.5b00482

Noncovalent Functionalization of Graphene and Graphene Oxide for Energy Materials, Biosensing, Catalytic, and Biomedical Applications
Open Access Through ACS AuthorChoice
This article is part of the Noncovalent Interactions special issue.

Chem. Rev., 2016, 116 (9), pp 5464–5519
DOI: 10.1021/acs.chemrev.5b00620

Graphitic Carbon Nitride (g-C3N4)-Based Photocatalysts for Artificial Photosynthesis and Environmental Remediation: Are We a Step Closer To Achieving Sustainability?

Chem. Rev., 2016, 116 (12), pp 7159–7329
DOI: 10.1021/acs.chemrev.6b00075

The Halogen Bond
Open Access Through ACS AuthorChoice
This article is part of the Frontiers in Macromolecular and Supramolecular Science special issue.

Chem. Rev., 2016, 116 (4), pp 2478–2601
DOI: 10.1021/acs.chemrev.5b00484

Synthesis, Properties, and Applications of Hollow Micro-/Nanostructures
This article is part of the Nanoparticle Chemistry special issue.

Chem. Rev., 2016, 116 (18), pp 10983–11060
DOI: 10.1021/acs.chemrev.5b00731

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Journal of the American Chemical Society

Practical Ni-Catalyzed Aryl–Alkyl Cross-Coupling of Secondary Redox-Active Esters

Open Access Through ACS AuthorChoice
J. Am. Chem. Soc., 2016, 138 (7), pp 2174–2177
DOI: 10.1021/jacs.6b00250

Radicals: Reactive Intermediates with Translational Potential
Open Access Through ACS AuthorChoice

J. Am. Chem. Soc., 2016, 138 (39), pp 12692–12714
DOI: 10.1021/jacs.6b08856

11-Step Total Synthesis of (−)-Maoecrystal V
Open Access Through ACS AuthorChoice

J. Am. Chem. Soc., 2016, 138 (30), pp 9425–9428
DOI: 10.1021/jacs.6b06623

Emerging Frontiers in Drug Delivery

J. Am. Chem. Soc., 2016, 138 (3), pp 704–717
DOI: 10.1021/jacs.5b09974

11-Step Total Synthesis of Pallambins C and D
Open Access Through ACS AuthorChoice

J. Am. Chem. Soc., 2016, 138 (24), pp 7536–7539
DOI: 10.1021/jacs.6b04816

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Read more most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Organic/Inorganic | Physical

Developing Better Pigments With Viavi Solutions’ Kelly Janssen

Kelly Janssen is a research chemist at Viavi Solutions. She uses her knowledge in chemistry to develop sol-gel silica encapsulation process that is used in paints for automobile. Her pigment passivation process improves on older, aluminum-based methods that would corrode in water. That means her pigments can be used in environmentally-friendly water-based paints.

In this video interview, Kelly Janssen discusses her work at Viavi Solutions shares her advice for people interested in mid-career scientific education:

ACS Editors’ Choice: Slow-Release Crop Fertilization — and More!

This week: slow-release crop fertilization, evaluating multiyear pesticide residue trials, photochemical reactions in a common insecticide — and more!

Each and every day, ACS grants free access to a new peer-reviewed research article from one of the Society’s journals. These articles are specially chosen by a team of scientific editors of ACS journals from around the world to highlight the transformative power of chemistry. Access to these articles will remain open to all as a public service.

Check out this week’s picks!
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Visible-Light-Mediated Anti-Markovnikov Hydration of Olefins

ACS Catal., 2017, 7, pp 1432–1437
DOI: 10.1021/acscatal.6b03388
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A Combined DFT/IM-MS Study on the Reaction Mechanism of Cationic Ru(II)-Catalyzed Hydroboration of Alkynes

ACS Catal., 2017, 7, pp 1361–1368
DOI: 10.1021/acscatal.6b03214
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Urea-Hydroxyapatite Nanohybrids for Slow Release of Nitrogen

ACS Nano, Article ASAP
DOI: 10.1021/acsnano.6b07781
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Comprehensive Analysis of the Value of Single Versus Multiple Year (Season) Crop

J. Agric. Food Chem., Article ASAP
DOI: 10.1021/acs.jafc.6b05106
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Photochemistry of Thin Solid Films of the Neonicotinoid Imidacloprid on Surfaces

Environ. Sci. Technol., Article ASAP
DOI: 10.1021/acs.est.6b04842
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Process Development and Crystallization in Oiling-Out System of a Novel Topical Antiandrogen

Org. Process Res. Dev., Article ASAP
DOI: 10.1021/acs.oprd.6b00392
***
Biomimetic Superhydrophobic Engineering Metal Surface with Hierarchical Structure and Tunable Adhesion: Design of Microscale Pattern

Ind. Eng. Chem. Res., Article ASAP
DOI: 10.1021/acs.iecr.6b03936
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Love ACS Editors’ Choice? Get a weekly e-mail of the latest ACS Editor’s Choice articles and never miss a breakthrough!

Most-Read Articles of 2016: Physical Chemistry

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in 2016, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list for 2016, but rather as an interesting perspective on where the chemistry community allocated their attention over the past year.

Of course, certain factors such as publishing earlier in the year, being featured in a special issue or being made open access may influence which items appeared on this list. To that end, ACS Axial will be publishing monthly updates on the most read chemistry articles of 2017 all year long. Don’t see your favorite papers on the list? Feel free to share your picks in the comments below.

Read more most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Organic/Inorganic
***

ACS Photonics

Plasmonic Nanoparticle Enhancement of Solution-Processed Solar Cells: Practical Limits and Opportunities
(Open Access Through ACS Editors’ Choice)

ACS Photonics, 2016, 3 (2), pp 158–173
DOI: 10.1021/acsphotonics.5b00428

Perovskite Nanocrystals as a Color Converter for Visible Light Communication
(Open Access Through ACS AuthorChoice)

ACS Photonics, 2016, 3 (7), pp 1150–1156
DOI: 10.1021/acsphotonics.6b00187

Nonlinear Optical Response of Organic–Inorganic Halide Perovskites
(Open Access Through ACS Editors’ Choice)


ACS Photonics, 2016, 3 (3), pp 371–377
DOI: 10.1021/acsphotonics.5b00563

Noble Metal Alloys for Plasmonics

ACS Photonics, 2016, 3 (4), pp 507–513
DOI: 10.1021/acsphotonics.5b00586

Harmonics Generation by Surface Plasmon Polaritons on Single Nanowires
(Open Access Through ACS Editors’ Choice)

ACS Photonics, 2016, 3 (8), pp 1446–1452
DOI: 10.1021/acsphotonics.5b00686
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Energy & Fuels

Role of Asphaltenes and Additives on the Viscosity and Microscopic Structure of Heavy Crude Oils
This article is part of the 16th International Conference on Petroleum Phase Behavior and Fouling special issue.

Energy Fuels, 2016, 30 (5), pp 3644–3651
DOI: 10.1021/acs.energyfuels.5b02103

Pyrolysis Oil Multiphase Behavior and Phase Stability: A Review

Energy Fuels, 2016, 30 (8), pp 6179–6200
DOI: 10.1021/acs.energyfuels.6b01287

CO2 Reaction Mechanisms with Hindered Alkanolamines: Control and Promotion of Reaction Pathways

Energy Fuels, 2016, 30 (2), pp 1223–1236
DOI: 10.1021/acs.energyfuels.5b02582

Review of NMR Characterization of Pyrolysis Oils

Energy Fuels, 2016, 30 (9), pp 6863–6880
DOI: 10.1021/acs.energyfuels.6b01002

Proton Conducting Nafion-Sulfonated Graphene Hybrid Membranes for Direct Methanol Fuel Cells with Reduced Methanol Crossover

Energy Fuels, 2016, 30 (1), pp 725–734
DOI: 10.1021/acs.energyfuels.5b02194
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Industrial & Engineering Chemistry Research

Toward the Development and Deployment of Large-Scale Carbon Dioxide Capture and Conversion Processes
Open Access Through ACS Editors’ Choice

Ind. Eng. Chem. Res., 2016, 55 (12), pp 3383–3419
DOI: 10.1021/acs.iecr.5b03277

Modeling and Dynamic Optimization of Microalgae Cultivation in Outdoor Open Ponds
Open Access Through ACS Editors’ Choice

Ind. Eng. Chem. Res., 2016, 55 (12), pp 3327–3337
DOI: 10.1021/acs.iecr.5b03209

Limitations of Breakthrough Curve Analysis in Fixed-Bed Adsorption
Open Access Through ACS Editors’ Choice

Ind. Eng. Chem. Res., 2016, 55 (16), pp 4734–4748
DOI: 10.1021/acs.iecr.6b00516

Solvent-Based Exfoliation via Sonication of Graphitic Materials for Graphene Manufacture

Ind. Eng. Chem. Res., 2016, 55 (4), pp 845–855
DOI: 10.1021/acs.iecr.5b03502

Recent Advancement of Coagulation–Flocculation and Its Application in Wastewater Treatment

Ind. Eng. Chem. Res., 2016, 55 (16), pp 4363–4389
DOI: 10.1021/acs.iecr.5b04703

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Journal of Chemical & Engineering Data

Investigation of Binary Mixtures Containing 1-Ethyl-3-methylimidazolium Bis(trifluoromethanesulfonyl)azanide and Ethylene Carbonate
Open Access Through ACS Editors’ Choice

J. Chem. Eng. Data, 2016, 61 (1), pp 114–123
DOI: 10.1021/acs.jced.5b00338

Target Synthesis of an Azo (N═N) Based Covalent Organic Framework with High CO2-over-N2 Selectivity and Benign Gas Storage Capability

J. Chem. Eng. Data, 2016, 61 (5), pp 1904–1909
DOI: 10.1021/acs.jced.6b00071
Comparison of Ionic Liquids to Conventional Organic Solvents for Extraction of Aromatics from Aliphatics


J. Chem. Eng. Data, 2016, 61 (5), pp 1685–1699
DOI: 10.1021/acs.jced.6b00077

Density, Viscosity, and Refractive Index of Ionic Liquid Mixtures Containing Cyano and Amino Acid-Based Anions

J. Chem. Eng. Data, 2016, 61 (1), pp 83–93
DOI: 10.1021/acs.jced.5b00242
Adsorption Equilibria of Water Vapor on Zeolite 3A, Zeolite 13X, and Dealuminated Y Zeolite


J. Chem. Eng. Data, 2016, 61 (4), pp 1547–1554
DOI: 10.1021/acs.jced.5b00927

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Journal of Chemical Information and Modeling

The Proximal Lilly Collection: Mapping, Exploring and Exploiting Feasible Chemical Space
Open Access Through ACS Editors’ Choice


J. Chem. Inf. Model., 2016, 56 (7), pp 1253–1266
DOI: 10.1021/acs.jcim.6b00173

Experimental and Chemoinformatics Study of Tautomerism in a Database of Commercially Available Screening Samples
Open Access Through ACS Editors’ Choice


J. Chem. Inf. Model., 2016, 56 (11), pp 2149–2161
DOI: 10.1021/acs.jcim.6b00338

Ultra-High-Throughput Structure-Based Virtual Screening for Small-Molecule Inhibitors of Protein–Protein Interactions

J. Chem. Inf. Model., 2016, 56 (2), pp 399–411
DOI: 10.1021/acs.jcim.5b00572

Understanding the Roles of the “Two QSARs”


J. Chem. Inf. Model., 2016, 56 (2), pp 269–274
DOI: 10.1021/acs.jcim.5b00229

Blind Pose Prediction, Scoring, and Affinity Ranking of the CSAR 2014 Dataset
Open Access Through ACS AuthorChoice

This article is part of the Community Structure Activity Resource (CSAR) special issue.


J. Chem. Inf. Model., 2016, 56 (6), pp 996–1003
DOI: 10.1021/acs.jcim.5b00337
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Journal of Chemical Theory and Computation

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field
Open Access Through ACS AuthorChoice


J. Chem. Theory Comput., 2016, 12 (1), pp 405–413
DOI: 10.1021/acs.jctc.5b00935

Demonstrating an Order-of-Magnitude Sampling Enhancement in Molecular Dynamics Simulations of Complex Protein Systems

J. Chem. Theory Comput., 2016, 12 (3), pp 1360–1367
DOI: 10.1021/acs.jctc.5b00913

A Practical Guide to Density Matrix Embedding Theory in Quantum Chemistry
Open Access Through ACS Editors’ Choice


J. Chem. Theory Comput., 2016, 12 (6), pp 2706–2719
DOI: 10.1021/acs.jctc.6b00316

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

J. Chem. Theory Comput., 2016, 12 (1), pp 281–296
DOI: 10.1021/acs.jctc.5b00864

Black-Box Description of Electron Correlation with the Spin-Extended Configuration Interaction Model: Implementation and Assessment

J. Chem. Theory Comput., 2016, 12 (4), pp 1741–1759
DOI: 10.1021/acs.jctc.6b00137

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The Journal of Physical Chemistry A

New Approach for Investigating Reaction Dynamics and Rates with Ab Initio Calculations
Open Access Through ACS Editors’ Choice


J. Phys. Chem. A, 2016, 120 (2), pp 299–305
DOI: 10.1021/acs.jpca.5b10667

How to Compute Electron Ionization Mass Spectra from First Principles
Open Access Through ACS Editors’ Choice


J. Phys. Chem. A, 2016, 120 (21), pp 3755–3766
DOI: 10.1021/acs.jpca.6b02907

Aqueous Photochemistry of Glyoxylic Acid
Open Access Through ACS AuthorChoice


J. Phys. Chem. A, 2016, 120 (21), pp 3817–3826
DOI: 10.1021/acs.jpca.6b00225

Semiempirical Modeling of Ag Nanoclusters: New Parameters for Optical Property Studies Enable Determination of Double Excitation Contributions to Plasmonic Excitation
Open Access Through ACS Editors’ Choice


J. Phys. Chem. A, 2016, 120 (26), pp 4542–4549
DOI: 10.1021/acs.jpca.6b04520

Rotational Spectrum and Structure of the 1,1-Difluoroethylene···Carbon Dioxide Complex
Open Access Through ACS AuthorChoice


J. Phys. Chem. A, 2016, 120 (2), pp 247–253
DOI: 10.1021/acs.jpca.5b11345
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The Journal of Physical Chemistry B

Molecular Modeling of Water Interfaces: From Molecular Spectroscopy to Thermodynamics
Open Access Through ACS Editors’ Choice


J. Phys. Chem. B, 2016, 120 (16), pp 3785–3796
DOI: 10.1021/acs.jpcb.6b01012

Statistical Analyses of Hydrophobic Interactions: A Mini-Review
Open Access Through ACS Editors’ Choice


J. Phys. Chem. B, 2016, 120 (27), pp 6455–6460
DOI: 10.1021/acs.jpcb.6b04082

Exploring the Dependence of QM/MM Calculations of Enzyme Catalysis on the Size of the QM Region
Open Access Through ACS Editors’ Choice


J. Phys. Chem. B, 2016, 120 (37), pp 9913–9921
DOI: 10.1021/acs.jpcb.6b07203

How Large Should the QM Region Be in QM/MM Calculations? The Case of Catechol O-Methyltransferase
Open Access Through ACS Editors’ Choice


J. Phys. Chem. B, 2016, 120 (44), pp 11381–11394
DOI: 10.1021/acs.jpcb.6b07814

Advanced Potential Energy Surfaces for Molecular Simulation

J. Phys. Chem. B, 2016, 120 (37), pp 9811–9832
DOI: 10.1021/acs.jpcb.6b06414
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The Journal of Physical Chemistry C

Recent Progress in Cancer Thermal Therapy Using Gold Nanoparticles


J. Phys. Chem. C, 2016, 120 (9), pp 4691–4716
DOI: 10.1021/acs.jpcc.5b11232

Flexible Graphene-Based Supercapacitors: A Review


J. Phys. Chem. C, 2016, 120 (8), pp 4153–4172
DOI: 10.1021/acs.jpcc.5b10187

Introducing Cu2O Thin Films as a Hole-Transport Layer in Efficient Planar Perovskite Solar Cell Structures
Open Access Through ACS AuthorChoice


J. Phys. Chem. C, 2016, 120 (3), pp 1428–1437
DOI: 10.1021/acs.jpcc.5b11540

Potential Application of Metal Dichalcogenides Double-Layered Heterostructures as Anode Materials for Li-Ion Batteries
Open Access Through ACS Editors’ Choice


J. Phys. Chem. C, 2016, 120 (9), pp 4779–4788
DOI: 10.1021/acs.jpcc.5b11677

Understanding Particle-Size-Dependent Electrochemical Properties of Li2MnO3-Based Positive Electrode Materials for Rechargeable Lithium Batteries
Open Access Through ACS Editors’ Choice


J. Phys. Chem. C, 2016, 120 (2), pp 875–885
DOI: 10.1021/acs.jpcc.5b10517
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The Journal of Physical Chemistry Letters

Cesium Lead Halide Perovskites with Improved Stability for Tandem Solar Cells

J. Phys. Chem. Lett., 2016, 7 (5), pp 746–751
DOI: 10.1021/acs.jpclett.6b00002

Surface- and Tip-Enhanced Raman Spectroscopy in Catalysis
Open Access Through ACS Editors’ Choice


J. Phys. Chem. Lett., 2016, 7 (8), pp 1570–1584
DOI: 10.1021/acs.jpclett.6b00147

Efficient Monolithic Perovskite/Silicon Tandem Solar Cell with Cell Area >1 cm2

J. Phys. Chem. Lett., 2016, 7 (1), pp 161–166
DOI: 10.1021/acs.jpclett.5b02686

Origin of J–V Hysteresis in Perovskite Solar Cells

J. Phys. Chem. Lett., 2016, 7 (5), pp 905–917
DOI: 10.1021/acs.jpclett.6b00215

Lead-Free Halide Double Perovskites via Heterovalent Substitution of Noble Metals

J. Phys. Chem. Lett., 2016, 7 (7), pp 1254–1259
DOI: 10.1021/acs.jpclett.6b00376

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Read more most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Organic/Inorganic

 

Most-Read Articles of 2016: Organic/Inorganic Chemistry

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in 2016, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list for 2016, but rather as an interesting perspective on where the chemistry community allocated their attention over the past year.

Of course, certain factors such as publishing earlier in the year, being featured in a special issue or being made open access may influence which items appeared on this list. To that end, ACS Axial will be publishing monthly updates on the most read chemistry articles of 2017 all year long. Don’t see your favorite papers on the list? Feel free to share your picks in the comments below.

Read more most-read articles: Analytical | Applied | Biological | Materials Science & Engineering  | Physical
***

ACS Catalysis

Cobalt-Catalyzed C–H Activation

ACS Catal., 2016, 6 (2), pp 498–525
DOI: 10.1021/acscatal.5b02344

Toward Benchmarking in Catalysis Science: Best Practices, Challenges, and Opportunities
Open Access Through ACS Editors’ Choice

ACS Catal., 2016, 6 (4), pp 2590–2602
DOI: 10.1021/acscatal.6b00183

Metal-Catalyzed Carboxylation of Organic (Pseudo)halides with CO2

ACS Catal., 2016, 6 (10), pp 6739–6749
DOI: 10.1021/acscatal.6b02124

Catalytic Methods for Aromatic C–H Amination: An Ideal Strategy for Nitrogen-Based Functional Molecules

ACS Catal., 2016, 6 (2), pp 610–633
DOI: 10.1021/acscatal.5b02417

Development of MOF-Derived Carbon-Based Nanomaterials for Efficient Catalysis

ACS Catal., 2016, 6 (9), pp 5887–5903
DOI: 10.1021/acscatal.6b01222

***

ACS Combinatorial Science

CuAAC: An Efficient Click Chemistry Reaction on Solid Phase

ACS Comb. Sci., 2016, 18 (1), pp 1–14
DOI: 10.1021/acscombsci.5b00087

Discovery of a Direct Ras Inhibitor by Screening a Combinatorial Library of Cell-Permeable Bicyclic Peptides
Open Access Through ACS Editors’ Choice

ACS Comb. Sci., 2016, 18 (1), pp 75–85
DOI: 10.1021/acscombsci.5b00164

Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening
Open Access Through ACS Editors’ Choice

ACS Comb. Sci., 2016, 18 (6), pp 320–329
DOI: 10.1021/acscombsci.5b00194

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines
Open Access Through ACS Editors’ Choice

ACS Comb. Sci., 2016, 18 (1), pp 51–64
DOI: 10.1021/acscombsci.5b00126

Simulated Screens of DNA Encoded Libraries: The Potential Influence of Chemical Synthesis Fidelity on Interpretation of Structure–Activity Relationships

ACS Comb. Sci., 2016, 18 (7), pp 415–424
DOI: 10.1021/acscombsci.6b00001

***

ACS Medicinal Chemistry Letters

Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR
Open Access Through ACS Editors’ Choice

ACS Med. Chem. Lett., 2016, 7 (4), pp 351–356
DOI: 10.1021/acsmedchemlett.6b00005

Hope and Disappointment: Covalent Inhibitors to Overcome Drug Resistance in Non-Small Cell Lung Cancer

ACS Med. Chem. Lett., 2016, 7 (1), pp 2–5
DOI: 10.1021/acsmedchemlett.5b00475

Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism
Open Access Through ACS Editors’ Choice

ACS Med. Chem. Lett., 2016, 7 (11), pp 977–982
DOI: 10.1021/acsmedchemlett.6b00195

High Drug Prices Hurt Everyone

ACS Med. Chem. Lett., 2016, 7 (6), pp 544–546
DOI: 10.1021/acsmedchemlett.6b00139

GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain
Open Access Through ACS Editors’ Choice

ACS Med. Chem. Lett., 2016, 7 (6), pp 552–557
DOI: 10.1021/acsmedchemlett.6b00092

***

Bioconjugate Chemistry

Simple Method To Prepare Oligonucleotide-Conjugated Antibodies and Its Application in Multiplex Protein Detection in Single Cells
Open Access Through ACS AuthorChoice

Bioconjugate Chem., 2016, 27 (1), pp 217–225
DOI: 10.1021/acs.bioconjchem.5b00613

Microwave-Triggered Smart Drug Release from Liposomes Co-encapsulating Doxorubicin and Salt for Local Combined Hyperthermia and Chemotherapy of Cancer
Open Access Through ACS Editors’ Choice

Bioconjugate Chem., 2016, 27 (12), pp 2931–2942
DOI: 10.1021/acs.bioconjchem.6b00603

18F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels–Alder Click Chemistry
Open Access Through ACS AuthorChoice

Bioconjugate Chem., 2016, 27 (2), pp 298–301
DOI: 10.1021/acs.bioconjchem.5b00504

New Chelators for Low Temperature Al18F-Labeling of Biomolecules
Open Access Through ACS Editors’ Choice

Bioconjugate Chem., 2016, 27 (3), pp 790–798
DOI: 10.1021/acs.bioconjchem.6b00012

NanoLuc: A Small Luciferase Is Brightening Up the Field of Bioluminescence

Bioconjugate Chem., 2016, 27 (5), pp 1175–1187
DOI: 10.1021/acs.bioconjchem.6b00112

***f

Inorganic Chemistry

Hydrogen Evolution from Water under Aerobic Conditions Catalyzed by a Cobalt ATCUN Metallopeptide
Open Access Through ACS Editors’ Choice

Inorg. Chem., 2016, 55 (4), pp 1355–1357
DOI: 10.1021/acs.inorgchem.5b02157

Lead-Free MA2CuClxBr4–x Hybrid Perovskites

Inorg. Chem., 2016, 55 (3), pp 1044–1052
DOI: 10.1021/acs.inorgchem.5b01896

Heterobimetallic N-Heterocyclic Carbene Complexes: A Synthetic, Spectroscopic, and Theoretical Study
Open Access Through ACS Editors’ Choice

Inorg. Chem., 2016, 55 (14), pp 6882–6891
DOI: 10.1021/acs.inorgchem.6b00222

Homogeneous Photocatalytic Water Oxidation with a Dinuclear CoIII–Pyridylmethylamine Complex

Inorg. Chem., 2016, 55 (3), pp 1154–1164
DOI: 10.1021/acs.inorgchem.5b02336

UiO-67-type Metal–Organic Frameworks with Enhanced Water Stability and Methane Adsorption Capacity

Inorg. Chem., 2016, 55 (5), pp 1986–1991
DOI: 10.1021/acs.inorgchem.5b02257
***

Journal of Medicinal Chemistry

Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis
Open Access Through ACS Editors’ Choice


J. Med. Chem., 2016, 59 (13), pp 6027–6044
DOI: 10.1021/acs.jmedchem.5b01833

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
Open Access Through ACS AuthorChoice


J. Med. Chem., 2016, 59 (10), pp 4443–4458
DOI: 10.1021/acs.jmedchem.5b01409

AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective


Open Access Through ACS AuthorChoice
J. Med. Chem., 2016, 59 (8), pp 3593–3608
DOI: 10.1021/acs.jmedchem.5b01273

The Medicinal Chemistry of Dengue Virus
Open Access Through ACS Editors’ Choice


J. Med. Chem., 2016, 59 (12), pp 5622–5649
DOI: 10.1021/acs.jmedchem.5b01653

A Real-World Perspective on Molecular Design
This article is part of the Computational Methods for Medicinal Chemistry special issue.


J. Med. Chem., 2016, 59 (9), pp 4087–4102
DOI: 10.1021/acs.jmedchem.5b01875

***

Journal of Natural Products

Natural Products as Sources of New Drugs from 1981 to 2014
Open Access Through ACS Editors’ Choice

J. Nat. Prod., 2016, 79 (3), pp 629–661
DOI: 10.1021/acs.jnatprod.5b01055

Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts
Open Access Through ACS Editors’ Choice

J. Nat. Prod., 2016, 79 (8), pp 1962–1970
DOI: 10.1021/acs.jnatprod.6b00215

Feeling Nature’s PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)
Open Access Through ACS Editors’ Choice

J. Nat. Prod., 2016, 79 (3), pp 616–628
DOI: 10.1021/acs.jnatprod.5b00947

LC-MS- and 1H NMR-Based Metabolomic Analysis and in Vitro Toxicological Assessment of 43 Aristolochia Species
Open Access Through ACS Editors’ Choice

J. Nat. Prod., 2016, 79 (1), pp 30–37
DOI: 10.1021/acs.jnatprod.5b00556

Chemodiversity of Ladder-Frame Prymnesin Polyethers in Prymnesium parvum
Open Access Through ACS Editors’ Choice

J. Nat. Prod., 2016, 79 (9), pp 2250–2256
DOI: 10.1021/acs.jnatprod.6b00345
***

The Journal of Organic Chemistry

Photoredox Catalysis in Organic Chemistry
Open Access Through ACS Editors’ Choice

J. Org. Chem., 2016, 81 (16), pp 6898–6926
DOI: 10.1021/acs.joc.6b01449

Recent Advances in C–H Functionalization

J. Org. Chem., 2016, 81 (2), pp 343–350
DOI: 10.1021/acs.joc.5b02818

Total Synthesis of a Diacetonide Derivative of Thuggacin A

J. Org. Chem., 2016, 81 (5), pp 1786–1797
DOI: 10.1021/acs.joc.5b02426

Chan–Evans–Lam Amination of Boronic Acid Pinacol (BPin) Esters: Overcoming the Aryl Amine Problem

J. Org. Chem., 2016, 81 (9), pp 3942–3950
DOI: 10.1021/acs.joc.6b00466

Palladium-Catalyzed Double-Suzuki–Miyaura Reactions Using Cyclic Dibenziodoniums: Synthesis of o-Tetraaryls
Open Access Through ACS Editors’ Choice

J. Org. Chem., 2016, 81 (4), pp 1317–1323
DOI: 10.1021/acs.joc.5b02255
***

Molecular Pharmaceutics

Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic Data
Open Access Through ACS Editors’ Choice


Mol. Pharmaceutics, 2016, 13 (7), pp 2524–2530
DOI: 10.1021/acs.molpharmaceut.6b00248

Applications of Deep Learning in Biomedicine

Mol. Pharmaceutics, 2016, 13 (5), pp 1445–1454
DOI: 10.1021/acs.molpharmaceut.5b00982

In Vitro and in Vivo Characterization of MOD-4023, a Long-Acting Carboxy-Terminal Peptide (CTP)-Modified Human Growth Hormone
Open Access Through ACS Editors’ Choice


Mol. Pharmaceutics, 2016, 13 (2), pp 631–639
DOI: 10.1021/acs.molpharmaceut.5b00868

Light Control of Insulin Release and Blood Glucose Using an Injectable Photoactivated Depot
Open Access Through ACS Editors’ Choice

Mol. Pharmaceutics, 2016, 13 (11), pp 3835–3841
DOI: 10.1021/acs.molpharmaceut.6b00633

Molecular Imaging of Pancreatic Cancer with Antibodies
Open Access Through ACS AuthorChoice

Mol. Pharmaceutics, 2016, 13 (1), pp 8–24
DOI: 10.1021/acs.molpharmaceut.5b00626
***

Organic Letters

Darwinolide, a New Diterpene Scaffold That Inhibits Methicillin-Resistant
Open Access Through ACS Editors’ Choice

Org. Lett., 2016, 18 (11), pp 2596–2599
DOI: 10.1021/acs.orglett.6b00979

Time Economical Total Synthesis of (−)-Oseltamivir

Org. Lett., 2016, 18 (14), pp 3426–3429
DOI: 10.1021/acs.orglett.6b01595

Total Synthesis of (+)-Vicenin-2
Open Access Through ACS Editors’ Choice

Org. Lett., 2016, 18 (18), pp 4488–4490
DOI: 10.1021/acs.orglett.6b02203

Total Synthesis of Lycopalhine A

Org. Lett., 2016, 18 (6), pp 1494–1496
DOI: 10.1021/acs.orglett.6b00338

Total Synthesis of (±)-Gracilioether F

Org. Lett., 2016, 18 (5), pp 1032–1035
DOI: 10.1021/acs.orglett.6b00161
***

Organic Process Research & Development

NMR Chemical Shifts of Trace Impurities: Industrially Preferred Solvents Used in Process and Green Chemistry
(Open Access Through ACS Editors’ Choice)

Org. Process Res. Dev., 2016, 20 (3), pp 661–667
DOI: 10.1021/acs.oprd.5b00417

Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

Org. Process Res. Dev., 2016, 20 (2), pp 140–177
DOI: 10.1021/op500305s

Vacuum Desiccator as a Simple, Robust, and Inexpensive NMR Tube Cleaner

Org. Process Res. Dev., 2016, 20 (2), pp 319–319
DOI: 10.1021/acs.oprd.6b00001

Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products
(Open Access Through ACS Editors’ Choice)

Org. Process Res. Dev., 2016, 20 (1), pp 2–25
DOI: 10.1021/acs.oprd.5b00325

Toward a More Holistic Framework for Solvent Selection
(Open Access Through ACS Editors’ Choice)

Org. Process Res. Dev., 2016, 20 (4), pp 760–773
DOI: 10.1021/acs.oprd.6b00015
***

Organometallics

An Editorial About Elemental Analysis
Organometallics, 2016, 35 (19), pp 3255–3256
DOI: 10.1021/acs.organomet.6b00720

A Frustrated Lewis Pair Based on a Cationic Aluminum Complex and Triphenylphosphine
(Open Access Through ACS Editors’ Choice)

Organometallics, 2016, 35 (2), pp 207–217
DOI: 10.1021/acs.organomet.5b00927

A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging
(Open Access Through ACS Editors’ Choice)

Organometallics, 2016, 35 (7), pp 1008–1014
DOI: 10.1021/acs.organomet.6b00059

Pyramidanes: The Covalent Form of the Ionic Compounds
(Open Access Through ACS Editors’ Choice)

Organometallics, 2016, 35 (3), pp 346–356
DOI: 10.1021/acs.organomet.5b00924

Legacy of Richard Heck
Organometallics, 2016, 35 (9), pp 1177–1178
DOI: 10.1021/acs.organomet.6b00261
***
Read more most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Physical

Most-Read Chemistry Articles of 2016: Materials Science & Engineering

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in 2016, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list for 2016, but rather as an interesting perspective on where the chemistry community allocated their attention over the past year.

Of course, certain factors such as publishing earlier in the year, being featured in a special issue or being made open access may influence which items appeared on this list. To that end, ACS Axial will be publishing monthly updates on the most read chemistry articles of 2017 all year long. Don’t see your favorite papers on the list? Feel free to share your picks in the comments below.

Read more most-read articles: Analytical | Applied | Biological | Organic/Inorganic | Physical
***

ACS Applied Materials & Interfaces

Coupling Hollow Fe3O4–Fe Nanoparticles with Graphene Sheets for High-Performance Electromagnetic Wave Absorbing Material

ACS Appl. Mater. Interfaces, 2016, 8 (6), pp 3730–3735
DOI: 10.1021/acsami.5b12789

Fabrication and Enhanced Photoelectrochemical Performance of MoS2/S-Doped g-C3N4 Heterojunction Film

ACS Appl. Mater. Interfaces, 2016, 8 (8), pp 5280–5289
DOI: 10.1021/acsami.5b11326

One-Step Synthesis of Water-Soluble MoS2 Quantum Dots via a Hydrothermal Method as a Fluorescent Probe for Hyaluronidase Detection

ACS Appl. Mater. Interfaces, 2016, 8 (18), pp 11272–11279
DOI: 10.1021/acsami.6b01166

Electrochemistry of Carbon Dioxide on Carbon Electrodes

ACS Appl. Mater. Interfaces, 2016, 8 (42), pp 28357–28371
DOI: 10.1021/acsami.5b09825

Cobalt Phosphide Hollow Polyhedron as Efficient Bifunctional Electrocatalysts for the Evolution Reaction of Hydrogen and Oxygen

ACS Appl. Mater. Interfaces, 2016, 8 (3), pp 2158–2165
DOI: 10.1021/acsami.5b10727
***

ACS Biomaterials Science & Engineering

Designing Biomaterials for 3D Printing
This article is part of the 3D Bioprinting special issue.

ACS Biomater. Sci. Eng., 2016, 2 (10), pp 1679–1693
DOI: 10.1021/acsbiomaterials.6b00121

3D Printing PDMS Elastomer in a Hydrophilic Support Bath via Freeform Reversible Embedding
This article is part of the 3D Bioprinting special issue.
Open Access Through ACS AuthorChoice

ACS Biomater. Sci. Eng., 2016, 2 (10), pp 1781–1786
DOI: 10.1021/acsbiomaterials.6b00170

Liquid-like Solids Support Cells in 3D
This article is part of the 3D Bioprinting special issue.
Open Access Through ACS Editors’ Choice

ACS Biomater. Sci. Eng., 2016, 2 (10), pp 1787–1795
DOI: 10.1021/acsbiomaterials.6b00218

Critical Length of PEG Grafts on lPEI/DNA Nanoparticles for Efficient in Vivo Delivery
Open Access Through ACS Editors’ Choice

ACS Biomater. Sci. Eng., 2016, 2 (4), pp 567–578
DOI: 10.1021/acsbiomaterials.5b00551

Polymeric Biomaterials for Medical Implants and Devices

ACS Biomater. Sci. Eng., 2016, 2 (4), pp 454–472
DOI: 10.1021/acsbiomaterials.5b00429
***

ACS Catalysis

Cobalt-Catalyzed C–H Activation

ACS Catal., 2016, 6 (2), pp 498–525
DOI: 10.1021/acscatal.5b02344

Toward Benchmarking in Catalysis Science: Best Practices, Challenges, and Opportunities
Open Access Through ACS Editors’ Choice

ACS Catal., 2016, 6 (4), pp 2590–2602
DOI: 10.1021/acscatal.6b00183

Metal-Catalyzed Carboxylation of Organic (Pseudo)halides with CO2

ACS Catal., 2016, 6 (10), pp 6739–6749
DOI: 10.1021/acscatal.6b02124

Catalytic Methods for Aromatic C–H Amination: An Ideal Strategy for Nitrogen-Based Functional Molecules

ACS Catal., 2016, 6 (2), pp 610–633
DOI: 10.1021/acscatal.5b02417

Development of MOF-Derived Carbon-Based Nanomaterials for Efficient Catalysis

ACS Catal., 2016, 6 (9), pp 5887–5903
DOI: 10.1021/acscatal.6b01222

***

ACS Macro Letters

Is Molecular Weight or Degree of Polymerization a Better Descriptor of Ultrasound-Induced Mechanochemical Transduction?
Open Access Through ACS Editors’ Choice

ACS Macro Lett., 2016, 5 (2), pp 177–180
DOI: 10.1021/acsmacrolett.5b00855

Stimuli-Responsive Polymers for Biological Detection and Delivery

ACS Macro Lett., 2016, 5 (1), pp 14–18
DOI: 10.1021/acsmacrolett.5b00862

Toughening Glassy Poly(lactide) with Block Copolymer Micelles
Open Access Through ACS Editors’ Choice

ACS Macro Lett., 2016, 5 (3), pp 359–364
DOI: 10.1021/acsmacrolett.6b00063

Synthesis of Macrocyclic Poly(3-hexylthiophene) and Poly(3-heptylselenophene) by Alkyne Homocoupling
Open Access Through ACS Editors’ Choice

ACS Macro Lett., 2016, 5 (10), pp 1075–1079
DOI: 10.1021/acsmacrolett.6b00603

Chemically Recyclable Biobased Polyurethanes
(Open Access Through ACS AuthorChoice)

ACS Macro Lett., 2016, 5 (4), pp 515–518
DOI: 10.1021/acsmacrolett.6b00193

***

ACS Nano

Tools for the Microbiome: Nano and Beyond
(Open Access Through ACS AuthorChoice)

ACS Nano, 2016, 10 (1), pp 6–37
DOI: 10.1021/acsnano.5b07826

Nanomedicines Eradicating Cancer Stem-like Cells in Vivo by pH-Triggered Intracellular Cooperative Action of Loaded Drugs
Open Access Through ACS Editors’ Choice

ACS Nano, 2016, 10 (6), pp 5643–5655
DOI: 10.1021/acsnano.6b00900

Nano Day: Celebrating the Next Decade of Nanoscience and Nanotechnology

ACS Nano, 2016, 10 (10), pp 9093–9103
DOI: 10.1021/acsnano.6b06655

Mechanical Chameleon through Dynamic Real-Time Plasmonic Tuning

ACS Nano, 2016, 10 (2), pp 1788–1794
DOI: 10.1021/acsnano.5b07472

Chiral Graphene Quantum Dots

ACS Nano, 2016, 10 (2), pp 1744–1755
DOI: 10.1021/acsnano.5b06369
***

ACS Photonics

Plasmonic Nanoparticle Enhancement of Solution-Processed Solar Cells: Practical Limits and Opportunities
(Open Access Through ACS Editors’ Choice)

ACS Photonics, 2016, 3 (2), pp 158–173
DOI: 10.1021/acsphotonics.5b00428

Perovskite Nanocrystals as a Color Converter for Visible Light Communication
(Open Access Through ACS AuthorChoice)

ACS Photonics, 2016, 3 (7), pp 1150–1156
DOI: 10.1021/acsphotonics.6b00187

Nonlinear Optical Response of Organic–Inorganic Halide Perovskites
(Open Access Through ACS Editors’ Choice)


ACS Photonics, 2016, 3 (3), pp 371–377
DOI: 10.1021/acsphotonics.5b00563

Noble Metal Alloys for Plasmonics

ACS Photonics, 2016, 3 (4), pp 507–513
DOI: 10.1021/acsphotonics.5b00586

Harmonics Generation by Surface Plasmon Polaritons on Single Nanowires
(Open Access Through ACS Editors’ Choice)

ACS Photonics, 2016, 3 (8), pp 1446–1452
DOI: 10.1021/acsphotonics.5b00686
***

ACS Sensors

Biosensors Based on Two-Dimensional MoS2

ACS Sens., 2016, 1 (1), pp 5–16
DOI: 10.1021/acssensors.5b00142

Aptamer-Modified Graphene-Based Catalytic Micromotors: Off–On Fluorescent Detection of Ricin
(Open Access Through ACS Editors’ Choice)

ACS Sens., 2016, 1 (3), pp 217–221
DOI: 10.1021/acssensors.5b00300

Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids
(Open Access Through ACS Editors’ Choice)

ACS Sens., 2016, 1 (7), pp 866–874
DOI: 10.1021/acssensors.6b00287

Noninvasive Alcohol Monitoring Using a Wearable Tattoo-Based Iontophoretic-Biosensing System

ACS Sens., 2016, 1 (8), pp 1011–1019
DOI: 10.1021/acssensors.6b00356

Wearable Chemical Sensors: Present Challenges and Future Prospects

ACS Sens., 2016, 1 (5), pp 464–482
DOI: 10.1021/acssensors.6b00250
***

ACS Sustainable Chemistry & Engineering

Spent Coffee Bioelastomeric Composite Foams for the Removal of Pb2+ and Hg2+ from Water

ACS Sustainable Chem. Eng., 2016, 4 (10), pp 5495–5502
DOI: 10.1021/acssuschemeng.6b01098

Total Utilization of Miscanthus Biomass, Lignin and Carbohydrates, Using Earth Abundant Nickel Catalyst
(Open Access Through ACS Editors’ Choice)

ACS Sustainable Chem. Eng., 2016, 4 (4), pp 2316–2322
DOI: 10.1021/acssuschemeng.5b01776

Base-Catalyzed Depolymerization of Biorefinery Lignins
(Open Access Through ACS Editors’ Choice)

ACS Sustainable Chem. Eng., 2016, 4 (3), pp 1474–1486
DOI: 10.1021/acssuschemeng.5b01451

Transformation of Chitin and Waste Shrimp Shells into Acetic Acid and Pyrrole
(Open Access Through ACS Editors’ Choice)

ACS Sustainable Chem. Eng., 2016, 4 (7), pp 3912–3920
DOI: 10.1021/acssuschemeng.6b00767

Depolymerization of Cellulose in Water Catalyzed by Phenylboronic Acid Derivatives
(Open Access Through ACS Editors’ Choice)

ACS Sustainable Chem. Eng., 2016, 4 (10), pp 5799–5803
DOI: 10.1021/acssuschemeng.6b01071
***

ACS Synthetic Biology

Synthetic RNA Polymerase III Promoters Facilitate High-Efficiency CRISPR–Cas9-Mediated Genome Editing in Yarrowia lipolytica
Open Access Through ACS AuthorChoice

ACS Synth. Biol., 2016, 5 (4), pp 356–359
DOI: 10.1021/acssynbio.5b00162

Corynebacterium glutamicum Metabolic Engineering with CRISPR Interference (CRISPRi)
Open Access Through ACS AuthorChoice

ACS Synth. Biol., 2016, 5 (5), pp 375–385
DOI: 10.1021/acssynbio.5b00216

Rapid and Efficient One-Step Metabolic Pathway Integration in E. coli

ACS Synth. Biol., 2016, 5 (7), pp 561–568
DOI: 10.1021/acssynbio.5b00187

Cell–Cell Communication in Yeast Using Auxin Biosynthesis and Auxin Responsive CRISPR Transcription Factors

ACS Synth. Biol., 2016, 5 (4), pp 279–286
DOI: 10.1021/acssynbio.5b00064

Multiple Gene Repression in Cyanobacteria Using CRISPRi

ACS Synth. Biol., 2016, 5 (3), pp 207–212
DOI: 10.1021/acssynbio.5b00264
***

Bioconjugate Chemistry

Simple Method To Prepare Oligonucleotide-Conjugated Antibodies and Its Application in Multiplex Protein Detection in Single Cells
Open Access Through ACS AuthorChoice

Bioconjugate Chem., 2016, 27 (1), pp 217–225
DOI: 10.1021/acs.bioconjchem.5b00613

Microwave-Triggered Smart Drug Release from Liposomes Co-encapsulating Doxorubicin and Salt for Local Combined Hyperthermia and Chemotherapy of Cancer
Open Access Through ACS Editors’ Choice

Bioconjugate Chem., 2016, 27 (12), pp 2931–2942
DOI: 10.1021/acs.bioconjchem.6b00603

18F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels–Alder Click Chemistry
Open Access Through ACS AuthorChoice

Bioconjugate Chem., 2016, 27 (2), pp 298–301
DOI: 10.1021/acs.bioconjchem.5b00504

New Chelators for Low Temperature Al18F-Labeling of Biomolecules
Open Access Through ACS Editors’ Choice

Bioconjugate Chem., 2016, 27 (3), pp 790–798
DOI: 10.1021/acs.bioconjchem.6b00012

NanoLuc: A Small Luciferase Is Brightening Up the Field of Bioluminescence

Bioconjugate Chem., 2016, 27 (5), pp 1175–1187
DOI: 10.1021/acs.bioconjchem.6b00112
***

Biomacromolecules

Optically Transparent Wood from a Nanoporous Cellulosic Template: Combining Functional and Structural Performance
Open Access Through ACS AuthorChoice

Biomacromolecules, 2016, 17 (4), pp 1358–1364
DOI: 10.1021/acs.biomac.6b00145

Biomimetic Polymers for Cardiac Tissue Engineering
Open Access Through ACS Editors’ Choice

Biomacromolecules, 2016, 17 (5), pp 1593–1601
DOI: 10.1021/acs.biomac.5b01734

Click Chemistry in Biomaterials, Nanomedicine, and Drug Delivery
Biomacromolecules, 2016, 17 (1), pp 1–3
DOI: 10.1021/acs.biomac.5b01660

Thermoresponsive Delivery of Paclitaxel by β-Cyclodextrin-Based Poly(N-isopropylacrylamide) Star Polymer via Inclusion Complexation
Open Access Through ACS Editors’ Choice

Biomacromolecules, 2016, 17 (12), pp 3957–3963
DOI: 10.1021/acs.biomac.6b01344

Thermodynamic Presynthetic Considerations for Ring-Opening Polymerization

Biomacromolecules, 2016, 17 (3), pp 699–709
DOI: 10.1021/acs.biomac.5b01698
***

Chemistry of Materials

Room-Temperature Intercalation and ∼1000-Fold Chemical Expansion for Scalable Preparation of High-Quality Graphene
Open Access Through ACS Editors’ Choice

Chem. Mater., 2016, 28 (7), pp 2138–2146
DOI: 10.1021/acs.chemmater.5b05043

Hidden Second Oxidation Step of Hummers Method
Open Access Through ACS Editors’ Choice

Chem. Mater., 2016, 28 (3), pp 756–764
DOI: 10.1021/acs.chemmater.5b03700

Stabilizing Perovskite Structures by Tuning Tolerance Factor: Formation of Formamidinium and Cesium Lead Iodide Solid-State Alloys

Chem. Mater., 2016, 28 (1), pp 284–292
DOI: 10.1021/acs.chemmater.5b04107

Synthesis, Properties, and Applications of Transition Metal-Doped Layered Transition Metal Dichalcogenides
Open Access Through ACS AuthorChoice

Chem. Mater., 2016, 28 (7), pp 1965–1974
DOI: 10.1021/acs.chemmater.6b00430

Which Font Looks Best in a Figure?

Chem. Mater., 2016, 28 (3), pp 689–690
DOI: 10.1021/acs.chemmater.6b00306

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Crystal Growth & Design

Solvates, Salts, and Cocrystals: A Proposal for a Feasible Classification System
Open Access Through ACS Editors’ Choice

Cryst. Growth Des., 2016, 16 (6), pp 3237–3243
DOI: 10.1021/acs.cgd.6b00200

It Isn’t, It Is: The C–H···X (X = O, N, F, Cl) Interaction Really Is Significant in Crystal Packing
Open Access Through ACS Editors’ Choice

Cryst. Growth Des., 2016, 16 (8), pp 4165–4168
DOI: 10.1021/acs.cgd.6b00736

How Surfactants Control Crystal Growth of Nanomaterials

Cryst. Growth Des., 2016, 16 (2), pp 1104–1133
DOI: 10.1021/acs.cgd.5b01465

Ion-Directed Synthesis of Indium-Derived 2,5-Thiophenedicarboxylate Metal–Organic Frameworks: Tuning Framework Dimensionality
Open Access Through ACS Editors’ Choice

Cryst. Growth Des., 2016, 16 (3), pp 1550–1558
DOI: 10.1021/acs.cgd.5b01680

Molecular Interactions in Crystal Structures with Z′ > 1
Open Access Through ACS Editors’ Choice

Cryst. Growth Des., 2016, 16 (5), pp 2988–3001
DOI: 10.1021/acs.cgd.6b00355
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Energy & Fuels

Role of Asphaltenes and Additives on the Viscosity and Microscopic Structure of Heavy Crude Oils
This article is part of the 16th International Conference on Petroleum Phase Behavior and Fouling special issue.

Energy Fuels, 2016, 30 (5), pp 3644–3651
DOI: 10.1021/acs.energyfuels.5b02103

Pyrolysis Oil Multiphase Behavior and Phase Stability: A Review

Energy Fuels, 2016, 30 (8), pp 6179–6200
DOI: 10.1021/acs.energyfuels.6b01287

CO2 Reaction Mechanisms with Hindered Alkanolamines: Control and Promotion of Reaction Pathways

Energy Fuels, 2016, 30 (2), pp 1223–1236
DOI: 10.1021/acs.energyfuels.5b02582

Review of NMR Characterization of Pyrolysis Oils

Energy Fuels, 2016, 30 (9), pp 6863–6880
DOI: 10.1021/acs.energyfuels.6b01002

Proton Conducting Nafion-Sulfonated Graphene Hybrid Membranes for Direct Methanol Fuel Cells with Reduced Methanol Crossover

Energy Fuels, 2016, 30 (1), pp 725–734
DOI: 10.1021/acs.energyfuels.5b02194
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Industrial & Engineering Chemistry Research

Toward the Development and Deployment of Large-Scale Carbon Dioxide Capture and Conversion Processes
Open Access Through ACS Editors’ Choice

Ind. Eng. Chem. Res., 2016, 55 (12), pp 3383–3419
DOI: 10.1021/acs.iecr.5b03277

Modeling and Dynamic Optimization of Microalgae Cultivation in Outdoor Open Ponds
Open Access Through ACS Editors’ Choice

Ind. Eng. Chem. Res., 2016, 55 (12), pp 3327–3337
DOI: 10.1021/acs.iecr.5b03209

Limitations of Breakthrough Curve Analysis in Fixed-Bed Adsorption
Open Access Through ACS Editors’ Choice

Ind. Eng. Chem. Res., 2016, 55 (16), pp 4734–4748
DOI: 10.1021/acs.iecr.6b00516

Solvent-Based Exfoliation via Sonication of Graphitic Materials for Graphene Manufacture

Ind. Eng. Chem. Res., 2016, 55 (4), pp 845–855
DOI: 10.1021/acs.iecr.5b03502

Recent Advancement of Coagulation–Flocculation and Its Application in Wastewater Treatment

Ind. Eng. Chem. Res., 2016, 55 (16), pp 4363–4389
DOI: 10.1021/acs.iecr.5b04703
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Inorganic Chemistry

Hydrogen Evolution from Water under Aerobic Conditions Catalyzed by a Cobalt ATCUN Metallopeptide
Open Access Through ACS Editors’ Choice

Inorg. Chem., 2016, 55 (4), pp 1355–1357
DOI: 10.1021/acs.inorgchem.5b02157

Lead-Free MA2CuClxBr4–x Hybrid Perovskites

Inorg. Chem., 2016, 55 (3), pp 1044–1052
DOI: 10.1021/acs.inorgchem.5b01896

Heterobimetallic N-Heterocyclic Carbene Complexes: A Synthetic, Spectroscopic, and Theoretical Study
Open Access Through ACS Editors’ Choice

Inorg. Chem., 2016, 55 (14), pp 6882–6891
DOI: 10.1021/acs.inorgchem.6b00222

Homogeneous Photocatalytic Water Oxidation with a Dinuclear CoIII–Pyridylmethylamine Complex

Inorg. Chem., 2016, 55 (3), pp 1154–1164
DOI: 10.1021/acs.inorgchem.5b02336

UiO-67-type Metal–Organic Frameworks with Enhanced Water Stability and Methane Adsorption Capacity

Inorg. Chem., 2016, 55 (5), pp 1986–1991
DOI: 10.1021/acs.inorgchem.5b02257

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Journal of Chemical & Engineering Data

Investigation of Binary Mixtures Containing 1-Ethyl-3-methylimidazolium Bis(trifluoromethanesulfonyl)azanide and Ethylene Carbonate
Open Access Through ACS Editors’ Choice

J. Chem. Eng. Data, 2016, 61 (1), pp 114–123
DOI: 10.1021/acs.jced.5b00338

Target Synthesis of an Azo (N═N) Based Covalent Organic Framework with High CO2-over-N2 Selectivity and Benign Gas Storage Capability

J. Chem. Eng. Data, 2016, 61 (5), pp 1904–1909
DOI: 10.1021/acs.jced.6b00071
Comparison of Ionic Liquids to Conventional Organic Solvents for Extraction of Aromatics from Aliphatics


J. Chem. Eng. Data, 2016, 61 (5), pp 1685–1699
DOI: 10.1021/acs.jced.6b00077

Density, Viscosity, and Refractive Index of Ionic Liquid Mixtures Containing Cyano and Amino Acid-Based Anions

J. Chem. Eng. Data, 2016, 61 (1), pp 83–93
DOI: 10.1021/acs.jced.5b00242
Adsorption Equilibria of Water Vapor on Zeolite 3A, Zeolite 13X, and Dealuminated Y Zeolite


J. Chem. Eng. Data, 2016, 61 (4), pp 1547–1554
DOI: 10.1021/acs.jced.5b00927

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The Journal of Physical Chemistry C

Recent Progress in Cancer Thermal Therapy Using Gold Nanoparticles

J. Phys. Chem. C, 2016, 120 (9), pp 4691–4716
DOI: 10.1021/acs.jpcc.5b11232

Flexible Graphene-Based Supercapacitors: A Review

J. Phys. Chem. C, 2016, 120 (8), pp 4153–4172
DOI: 10.1021/acs.jpcc.5b10187

Introducing Cu2O Thin Films as a Hole-Transport Layer in Efficient Planar Perovskite Solar Cell Structures
Open Access Through ACS AuthorChoice


J. Phys. Chem. C, 2016, 120 (3), pp 1428–1437
DOI: 10.1021/acs.jpcc.5b11540

Potential Application of Metal Dichalcogenides Double-Layered Heterostructures as Anode Materials for Li-Ion Batteries
Open Access Through ACS Editors’ Choice


J. Phys. Chem. C, 2016, 120 (9), pp 4779–4788
DOI: 10.1021/acs.jpcc.5b11677

Understanding Particle-Size-Dependent Electrochemical Properties of Li2MnO3-Based Positive Electrode Materials for Rechargeable Lithium Batteries
Open Access Through ACS Editors’ Choice


J. Phys. Chem. C, 2016, 120 (2), pp 875–885
DOI: 10.1021/acs.jpcc.5b10517
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The Journal of Physical Chemistry Letters

Cesium Lead Halide Perovskites with Improved Stability for Tandem Solar Cells

J. Phys. Chem. Lett., 2016, 7 (5), pp 746–751
DOI: 10.1021/acs.jpclett.6b00002

Surface- and Tip-Enhanced Raman Spectroscopy in Catalysis
Open Access Through ACS Editors’ Choice


J. Phys. Chem. Lett., 2016, 7 (8), pp 1570–1584
DOI: 10.1021/acs.jpclett.6b00147

Efficient Monolithic Perovskite/Silicon Tandem Solar Cell with Cell Area >1 cm2

J. Phys. Chem. Lett., 2016, 7 (1), pp 161–166
DOI: 10.1021/acs.jpclett.5b02686

Origin of J–V Hysteresis in Perovskite Solar Cells

J. Phys. Chem. Lett., 2016, 7 (5), pp 905–917
DOI: 10.1021/acs.jpclett.6b00215

Lead-Free Halide Double Perovskites via Heterovalent Substitution of Noble Metals

J. Phys. Chem. Lett., 2016, 7 (7), pp 1254–1259
DOI: 10.1021/acs.jpclett.6b00376

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Langmuir

Distance-Dependent Measurements of the Conductance of Porphyrin Nanorods Studied with Conductive Probe Atomic Force Microscopy

Langmuir, Article ASAP
DOI: 10.1021/acs.langmuir.6b03525

Water-Mediated Interactions between Hydrophilic and Hydrophobic Surfaces

Open Access Through ACS Editors’ Choice
Langmuir, 2016, 32 (35), pp 8767–8782
DOI: 10.1021/acs.langmuir.6b01727

Soft-Mechanochemistry: Mechanochemistry Inspired by Nature
Open Access Through ACS Editors’ Choice

Langmuir, 2016, 32 (29), pp 7265–7276
DOI: 10.1021/acs.langmuir.6b01768

Surface-Cross-Linked Micelles as Multifunctionalized Organic Nanoparticles for Controlled Release, Light Harvesting, and Catalysis
Open Access Through ACS Editors’ Choice

Langmuir, 2016, 32 (23), pp 5703–5713
DOI: 10.1021/acs.langmuir.6b01162

Plasmon Response and Electron Dynamics in Charged Metallic Nanoparticles
Open Access Through ACS Editors’ Choice

Langmuir, 2016, 32 (11), pp 2829–2840
DOI: 10.1021/acs.langmuir.6b00112
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Macromolecules

A Critical Appraisal of RAFT-Mediated Polymerization-Induced Self-Assembly
Open Access Through ACS Editors’ Choice

Macromolecules, 2016, 49 (6), pp 1985–2001
DOI: 10.1021/acs.macromol.5b02602

What Is Next in Single-Chain Nanoparticles?
Open Access Through ACS Editors’ Choice

Macromolecules, 2016, 49 (1), pp 2–14
DOI: 10.1021/acs.macromol.5b01456

Biosynthetic Polymers as Functional Materials
Open Access Through ACS Editors’ Choice

Macromolecules, 2016, 49 (12), pp 4379–4394
DOI: 10.1021/acs.macromol.6b00439

Polymer Interfaces: Synthetic Strategies Enabling Functionality, Adaptivity, and Spatial Control
Open Access Through ACS Editors’ Choice

Macromolecules, 2016, 49 (14), pp 5001–5016
DOI: 10.1021/acs.macromol.6b00650

Aliphatic Polyester Block Polymer Design
Open Access Through ACS AuthorChoice

Macromolecules, 2016, 49 (7), pp 2419–2428
DOI: 10.1021/acs.macromol.6b00211
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Nano Letters

Defects Engineered Monolayer MoS2 for Improved Hydrogen Evolution Reaction

Nano Lett., 2016, 16 (2), pp 1097–1103
DOI: 10.1021/acs.nanolett.5b04331

Perfect Photon-to-Hydrogen Conversion Efficiency

Nano Lett., 2016, 16 (3), pp 1776–1781
DOI: 10.1021/acs.nanolett.5b04813

Multispectral Chiral Imaging with a Metalens

Open Access Through ACS Editors’ Choice

Nano Lett., 2016, 16 (7), pp 4595–4600
DOI: 10.1021/acs.nanolett.6b01897

Feeding Single-Walled Carbon Nanotubes or Graphene to Silkworms for Reinforced Silk Fibers

Nano Lett., 2016, 16 (10), pp 6695–6700
DOI: 10.1021/acs.nanolett.6b03597

Supercapacitors Based on Three-Dimensional Hierarchical Graphene Aerogels with Periodic Macropores

Nano Lett., 2016, 16 (6), pp 3448–3456
DOI: 10.1021/acs.nanolett.5b04965
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Read more most-read articles: Analytical | Applied | BiologicalOrganic/Inorganic | Physical

Most-Read Articles of 2016: Biological Chemistry

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in 2016, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list for 2016, but rather as an interesting perspective on where the chemistry community allocated their attention over the past year.

Of course, certain factors such as publishing earlier in the year, being featured in a special issue or being made open access may influence which items appeared on this list. To that end, ACS Axial will be publishing monthly updates on the most read chemistry articles of 2017 all year long. Don’t see your favorite papers on the list? Feel free to share your picks in the comments below.

Read more most-read articles: Analytical | Applied | Materials Science & Engineering | Organic/Inorganic | Physical
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ACS Biomaterials Science & Engineering

Designing Biomaterials for 3D Printing
This article is part of the 3D Bioprinting special issue.

ACS Biomater. Sci. Eng., 2016, 2 (10), pp 1679–1693
DOI: 10.1021/acsbiomaterials.6b00121

3D Printing PDMS Elastomer in a Hydrophilic Support Bath via Freeform Reversible Embedding
This article is part of the 3D Bioprinting special issue.
Open Access Through ACS AuthorChoice

ACS Biomater. Sci. Eng., 2016, 2 (10), pp 1781–1786
DOI: 10.1021/acsbiomaterials.6b00170

Liquid-like Solids Support Cells in 3D
This article is part of the 3D Bioprinting special issue.
Open Access Through ACS Editors’ Choice

ACS Biomater. Sci. Eng., 2016, 2 (10), pp 1787–1795
DOI: 10.1021/acsbiomaterials.6b00218

Critical Length of PEG Grafts on lPEI/DNA Nanoparticles for Efficient in Vivo Delivery
Open Access Through ACS Editors’ Choice

ACS Biomater. Sci. Eng., 2016, 2 (4), pp 567–578
DOI: 10.1021/acsbiomaterials.5b00551

Polymeric Biomaterials for Medical Implants and Devices

ACS Biomater. Sci. Eng., 2016, 2 (4), pp 454–472
DOI: 10.1021/acsbiomaterials.5b00429

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ACS Catalysis

Cobalt-Catalyzed C–H Activation

ACS Catal., 2016, 6 (2), pp 498–525
DOI: 10.1021/acscatal.5b02344

Toward Benchmarking in Catalysis Science: Best Practices, Challenges, and Opportunities
Open Access Through ACS Editors’ Choice

ACS Catal., 2016, 6 (4), pp 2590–2602
DOI: 10.1021/acscatal.6b00183

Metal-Catalyzed Carboxylation of Organic (Pseudo)halides with CO2

ACS Catal., 2016, 6 (10), pp 6739–6749
DOI: 10.1021/acscatal.6b02124

Catalytic Methods for Aromatic C–H Amination: An Ideal Strategy for Nitrogen-Based Functional Molecules

ACS Catal., 2016, 6 (2), pp 610–633
DOI: 10.1021/acscatal.5b02417

Development of MOF-Derived Carbon-Based Nanomaterials for Efficient Catalysis

ACS Catal., 2016, 6 (9), pp 5887–5903
DOI: 10.1021/acscatal.6b01222
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ACS Central Science

Catalytic Oxidation of Methane into Methanol over Copper-Exchanged Zeolites with Oxygen at Low Temperature
(Open Access Through ACS AuthorChoice)

ACS Cent. Sci., 2016, 2 (6), pp 424–429
DOI: 10.1021/acscentsci.6b00139

Achieving Gender Balance in the Chemistry Professoriate Is Not Rocket Science
(Open Access Through ACS AuthorChoice)
ACS Cent. Sci., 2016, 2 (4), pp 181–182
DOI: 10.1021/acscentsci.6b00102

Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles
(Open Access Through ACS AuthorChoice)

ACS Cent. Sci., 2016, 2 (10), pp 687–701
DOI: 10.1021/acscentsci.6b00086

Synthetic Organic Electrochemistry: An Enabling and Innately Sustainable Method
(Open Access Through ACS AuthorChoice)

ACS Cent. Sci., 2016, 2 (5), pp 302–308
DOI: 10.1021/acscentsci.6b00091

Neural Networks for the Prediction of Organic Chemistry Reactions
(Open Access Through ACS AuthorChoice)

ACS Cent. Sci., 2016, 2 (10), pp 725–732
DOI: 10.1021/acscentsci.6b00219
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ACS Chemical Biology

Ligand Discovery for a Peptide-Binding GPCR by Structure-Based Screening of Fragment- and Lead-Like Chemical Libraries

ACS Chem. Biol., Article ASAP
DOI: 10.1021/acschembio.6b00646

Strategies and Approaches of Targeting STAT3 for Cancer Treatment

ACS Chem. Biol., 2016, 11 (2), pp 308–318
DOI: 10.1021/acschembio.5b00945

Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering

ACS Chem. Biol., 2016, 11 (3), pp 681–688
DOI: 10.1021/acschembio.5b01019

A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo

ACS Chem. Biol., 2016, 11 (4), pp 1058–1065
DOI: 10.1021/acschembio.5b01006

Why Nature Chose Selenium

ACS Chem. Biol., 2016, 11 (4), pp 821–841
DOI: 10.1021/acschembio.6b00031
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ACS Chemical Neuroscience

Lost in Translation: The Death of Basic Science
ACS Chem. Neurosci., 2016, 7 (8), pp 1024–1024
DOI: 10.1021/acschemneuro.6b00206

Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery
Open Access Through ACS Editors’ Choice


ACS Chem. Neurosci., 2016, 7 (6), pp 767–775
DOI: 10.1021/acschemneuro.6b00029

Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model
Open Access Through ACS Editors’ Choice

ACS Chem. Neurosci., 2016, 7 (5), pp 588–598
DOI: 10.1021/acschemneuro.5b00342

Single-Molecule Imaging of Individual Amyloid Protein Aggregates in Human Biofluids

(Open Access Through ACS AuthorChoice)

ACS Chem. Neurosci., 2016, 7 (3), pp 399–406
DOI: 10.1021/acschemneuro.5b00324

The Critical Role of Organic Chemistry in Drug Discovery

ACS Chem. Neurosci., 2016, 7 (10), pp 1315–1316
DOI: 10.1021/acschemneuro.6b00280
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ACS Infectious Diseases

Zika Virus: Diagnosis, Therapeutics, and Vaccine
Open Access Through ACS Editors’ Choice
ACS Infect. Dis., 2016, 2 (3), pp 170–172
DOI: 10.1021/acsinfecdis.6b00030

Zika Virus Genomic RNA Possesses Conserved G-Quadruplexes Characteristic of the Flaviviridae Family
Open Access Through ACS Editors’ Choice

ACS Infect. Dis., 2016, 2 (10), pp 674–681
DOI: 10.1021/acsinfecdis.6b00109

Dipeptide-Based Metabolic Labeling of Bacterial Cells for Endogenous Antibody Recruitment
Open Access Through ACS Editors’ Choice

ACS Infect. Dis., 2016, 2 (4), pp 302–309
DOI: 10.1021/acsinfecdis.6b00007

A Small-Molecule Screening Platform for the Discovery of Inhibitors of Undecaprenyl Diphosphate Synthase
Open Access Through ACS Editors’ Choice

ACS Infect. Dis., 2016, 2 (7), pp 489–499
DOI: 10.1021/acsinfecdis.6b00044

De Novo Sequencing and Resurrection of a Human Astrovirus-Neutralizing Antibody
Open Access Through ACS Editors’ Choice

ACS Infect. Dis., 2016, 2 (5), pp 313–321
DOI: 10.1021/acsinfecdis.6b00026

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ACS Medicinal Chemistry Letters

Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR
Open Access Through ACS Editors’ Choice

ACS Med. Chem. Lett., 2016, 7 (4), pp 351–356
DOI: 10.1021/acsmedchemlett.6b00005

Hope and Disappointment: Covalent Inhibitors to Overcome Drug Resistance in Non-Small Cell Lung Cancer

ACS Med. Chem. Lett., 2016, 7 (1), pp 2–5
DOI: 10.1021/acsmedchemlett.5b00475

Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism
Open Access Through ACS Editors’ Choice

ACS Med. Chem. Lett., 2016, 7 (11), pp 977–982
DOI: 10.1021/acsmedchemlett.6b00195

High Drug Prices Hurt Everyone

ACS Med. Chem. Lett., 2016, 7 (6), pp 544–546
DOI: 10.1021/acsmedchemlett.6b00139

GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain
Open Access Through ACS Editors’ Choice

ACS Med. Chem. Lett., 2016, 7 (6), pp 552–557
DOI: 10.1021/acsmedchemlett.6b00092
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ACS Synthetic Biology

Synthetic RNA Polymerase III Promoters Facilitate High-Efficiency CRISPR–Cas9-Mediated Genome Editing in Yarrowia lipolytica
Open Access Through ACS AuthorChoice

ACS Synth. Biol., 2016, 5 (4), pp 356–359
DOI: 10.1021/acssynbio.5b00162

Corynebacterium glutamicum Metabolic Engineering with CRISPR Interference (CRISPRi)
Open Access Through ACS AuthorChoice

ACS Synth. Biol., 2016, 5 (5), pp 375–385
DOI: 10.1021/acssynbio.5b00216

Rapid and Efficient One-Step Metabolic Pathway Integration in E. coli

ACS Synth. Biol., 2016, 5 (7), pp 561–568
DOI: 10.1021/acssynbio.5b00187

Cell–Cell Communication in Yeast Using Auxin Biosynthesis and Auxin Responsive CRISPR Transcription Factors

ACS Synth. Biol., 2016, 5 (4), pp 279–286
DOI: 10.1021/acssynbio.5b00064

Multiple Gene Repression in Cyanobacteria Using CRISPRi

ACS Synth. Biol., 2016, 5 (3), pp 207–212
DOI: 10.1021/acssynbio.5b00264

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Biochemistry

On the Temperature Dependence of Enzyme-Catalyzed Rates
Open Access Through ACS Editors’ Choice

Biochemistry, 2016, 55 (12), pp 1681–1688
DOI: 10.1021/acs.biochem.5b01094

A Soluble, Folded Protein without Charged Amino Acid Residues
Open Access Through ACS Editors’ Choice

Biochemistry, 2016, 55 (28), pp 3949–3956
DOI: 10.1021/acs.biochem.6b00269

PRC2 and SWI/SNF Chromatin Remodeling Complexes in Health and Disease
This article is part of the Epigenetics special issue.

Biochemistry, 2016, 55 (11), pp 1600–1614
DOI: 10.1021/acs.biochem.5b01191

Discovery and Mechanism of Highly Efficient Cyclic Cell-Penetrating Peptides

Biochemistry, 2016, 55 (18), pp 2601–2612
DOI: 10.1021/acs.biochem.6b00226

Biochemical Methods To Investigate lncRNA and the Influence of lncRNA:Protein Complexes on Chromatin
This article is part of the Epigenetics special issue.

Biochemistry, 2016, 55 (11), pp 1615–1630
DOI: 10.1021/acs.biochem.5b01141
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Bioconjugate Chemistry

Simple Method To Prepare Oligonucleotide-Conjugated Antibodies and Its Application in Multiplex Protein Detection in Single Cells
Open Access Through ACS AuthorChoice

Bioconjugate Chem., 2016, 27 (1), pp 217–225
DOI: 10.1021/acs.bioconjchem.5b00613

Microwave-Triggered Smart Drug Release from Liposomes Co-encapsulating Doxorubicin and Salt for Local Combined Hyperthermia and Chemotherapy of Cancer
Open Access Through ACS Editors’ Choice

Bioconjugate Chem., 2016, 27 (12), pp 2931–2942
DOI: 10.1021/acs.bioconjchem.6b00603

18F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels–Alder Click Chemistry
Open Access Through ACS AuthorChoice

Bioconjugate Chem., 2016, 27 (2), pp 298–301
DOI: 10.1021/acs.bioconjchem.5b00504

New Chelators for Low Temperature Al18F-Labeling of Biomolecules
Open Access Through ACS Editors’ Choice

Bioconjugate Chem., 2016, 27 (3), pp 790–798
DOI: 10.1021/acs.bioconjchem.6b00012

NanoLuc: A Small Luciferase Is Brightening Up the Field of Bioluminescence

Bioconjugate Chem., 2016, 27 (5), pp 1175–1187
DOI: 10.1021/acs.bioconjchem.6b00112

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Biomacromolecules

Optically Transparent Wood from a Nanoporous Cellulosic Template: Combining Functional and Structural Performance
Open Access Through ACS AuthorChoice

Biomacromolecules, 2016, 17 (4), pp 1358–1364
DOI: 10.1021/acs.biomac.6b00145

Biomimetic Polymers for Cardiac Tissue Engineering
Open Access Through ACS Editors’ Choice

Biomacromolecules, 2016, 17 (5), pp 1593–1601
DOI: 10.1021/acs.biomac.5b01734

Click Chemistry in Biomaterials, Nanomedicine, and Drug Delivery
Biomacromolecules, 2016, 17 (1), pp 1–3
DOI: 10.1021/acs.biomac.5b01660

Thermoresponsive Delivery of Paclitaxel by β-Cyclodextrin-Based Poly(N-isopropylacrylamide) Star Polymer via Inclusion Complexation
Open Access Through ACS Editors’ Choice

Biomacromolecules, 2016, 17 (12), pp 3957–3963
DOI: 10.1021/acs.biomac.6b01344

Thermodynamic Presynthetic Considerations for Ring-Opening Polymerization

Biomacromolecules, 2016, 17 (3), pp 699–709
DOI: 10.1021/acs.biomac.5b01698

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Journal of Agricultural and Food Chemistry

Determination of Glyphosate Levels in Breast Milk Samples from Germany by LC-MS/MS and GC-MS/MS
Open Access Through ACS AuthorChoice

J. Agric. Food Chem., 2016, 64 (6), pp 1414–1421
DOI: 10.1021/acs.jafc.5b05852

Antioxidant Mechanism of Betaine without Free Radical Scavenging Ability
Open Access Through ACS AuthorChoice

J. Agric. Food Chem., 2016, 64 (42), pp 7921–7930
DOI: 10.1021/acs.jafc.6b03592

Nanoencapsulation, Nano-guard for Pesticides: A New Window for Safe Application

J. Agric. Food Chem., 2016, 64 (7), pp 1447–1483
DOI: 10.1021/acs.jafc.5b05214

Sulfoglucosides as Novel Modified Forms of the Mycotoxins Alternariol and Alternariol Monomethyl Ether
Open Access Through ACS AuthorChoice

J. Agric. Food Chem., 2016, 64 (46), pp 8892–8901
DOI: 10.1021/acs.jafc.6b03120

Global Adoption of Genetically Modified (GM) Crops: Challenges for the Public Sector

J. Agric. Food Chem., 2016, 64 (2), pp 394–402
DOI: 10.1021/acs.jafc.5b05116

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Journal of Chemical Theory and Computation

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field
Open Access Through ACS AuthorChoice


J. Chem. Theory Comput., 2016, 12 (1), pp 405–413
DOI: 10.1021/acs.jctc.5b00935

Demonstrating an Order-of-Magnitude Sampling Enhancement in Molecular Dynamics Simulations of Complex Protein Systems

J. Chem. Theory Comput., 2016, 12 (3), pp 1360–1367
DOI: 10.1021/acs.jctc.5b00913

A Practical Guide to Density Matrix Embedding Theory in Quantum Chemistry
Open Access Through ACS Editors’ Choice

J. Chem. Theory Comput., 2016, 12 (6), pp 2706–2719
DOI: 10.1021/acs.jctc.6b00316

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

J. Chem. Theory Comput., 2016, 12 (1), pp 281–296
DOI: 10.1021/acs.jctc.5b00864

Black-Box Description of Electron Correlation with the Spin-Extended Configuration Interaction Model: Implementation and Assessment

J. Chem. Theory Comput., 2016, 12 (4), pp 1741–1759
DOI: 10.1021/acs.jctc.6b00137

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Journal of Medicinal Chemistry

Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis
Open Access Through ACS Editors’ Choice


J. Med. Chem., 2016, 59 (13), pp 6027–6044
DOI: 10.1021/acs.jmedchem.5b01833

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
Open Access Through ACS AuthorChoice


J. Med. Chem., 2016, 59 (10), pp 4443–4458
DOI: 10.1021/acs.jmedchem.5b01409

AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective


Open Access Through ACS AuthorChoice
J. Med. Chem., 2016, 59 (8), pp 3593–3608
DOI: 10.1021/acs.jmedchem.5b01273

The Medicinal Chemistry of Dengue Virus
Open Access Through ACS Editors’ Choice


J. Med. Chem., 2016, 59 (12), pp 5622–5649
DOI: 10.1021/acs.jmedchem.5b01653

A Real-World Perspective on Molecular Design
This article is part of the Computational Methods for Medicinal Chemistry special issue.


J. Med. Chem., 2016, 59 (9), pp 4087–4102
DOI: 10.1021/acs.jmedchem.5b01875

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Journal of Natural Products

Natural Products as Sources of New Drugs from 1981 to 2014
Open Access Through ACS Editors’ Choice

J. Nat. Prod., 2016, 79 (3), pp 629–661
DOI: 10.1021/acs.jnatprod.5b01055

Affinity Crystallography: A New Approach to Extracting High-Affinity Enzyme Inhibitors from Natural Extracts
Open Access Through ACS Editors’ Choice

J. Nat. Prod., 2016, 79 (8), pp 1962–1970
DOI: 10.1021/acs.jnatprod.6b00215

Feeling Nature’s PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)
Open Access Through ACS Editors’ Choice

J. Nat. Prod., 2016, 79 (3), pp 616–628
DOI: 10.1021/acs.jnatprod.5b00947

LC-MS- and 1H NMR-Based Metabolomic Analysis and in Vitro Toxicological Assessment of 43 Aristolochia Species
Open Access Through ACS Editors’ Choice

J. Nat. Prod., 2016, 79 (1), pp 30–37
DOI: 10.1021/acs.jnatprod.5b00556

Chemodiversity of Ladder-Frame Prymnesin Polyethers in Prymnesium parvum
Open Access Through ACS Editors’ Choice

J. Nat. Prod., 2016, 79 (9), pp 2250–2256
DOI: 10.1021/acs.jnatprod.6b00345
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The Journal of Physical Chemistry B

Molecular Modeling of Water Interfaces: From Molecular Spectroscopy to Thermodynamics
Open Access Through ACS Editors’ Choice


J. Phys. Chem. B, 2016, 120 (16), pp 3785–3796
DOI: 10.1021/acs.jpcb.6b01012

Statistical Analyses of Hydrophobic Interactions: A Mini-Review
Open Access Through ACS Editors’ Choice


J. Phys. Chem. B, 2016, 120 (27), pp 6455–6460
DOI: 10.1021/acs.jpcb.6b04082

Exploring the Dependence of QM/MM Calculations of Enzyme Catalysis on the Size of the QM Region
Open Access Through ACS Editors’ Choice


J. Phys. Chem. B, 2016, 120 (37), pp 9913–9921
DOI: 10.1021/acs.jpcb.6b07203

How Large Should the QM Region Be in QM/MM Calculations? The Case of Catechol O-Methyltransferase
Open Access Through ACS Editors’ Choice


J. Phys. Chem. B, 2016, 120 (44), pp 11381–11394
DOI: 10.1021/acs.jpcb.6b07814

Advanced Potential Energy Surfaces for Molecular Simulation

J. Phys. Chem. B, 2016, 120 (37), pp 9811–9832
DOI: 10.1021/acs.jpcb.6b06414

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The Journal of Physical Chemistry Letters

Cesium Lead Halide Perovskites with Improved Stability for Tandem Solar Cells

J. Phys. Chem. Lett., 2016, 7 (5), pp 746–751
DOI: 10.1021/acs.jpclett.6b00002

Surface- and Tip-Enhanced Raman Spectroscopy in Catalysis
Open Access Through ACS Editors’ Choice


J. Phys. Chem. Lett., 2016, 7 (8), pp 1570–1584
DOI: 10.1021/acs.jpclett.6b00147

Efficient Monolithic Perovskite/Silicon Tandem Solar Cell with Cell Area >1 cm2

J. Phys. Chem. Lett., 2016, 7 (1), pp 161–166
DOI: 10.1021/acs.jpclett.5b02686

Origin of J–V Hysteresis in Perovskite Solar Cells

J. Phys. Chem. Lett., 2016, 7 (5), pp 905–917
DOI: 10.1021/acs.jpclett.6b00215

Lead-Free Halide Double Perovskites via Heterovalent Substitution of Noble Metals

J. Phys. Chem. Lett., 2016, 7 (7), pp 1254–1259
DOI: 10.1021/acs.jpclett.6b00376

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Journal of Proteome Research

Proteomics Quality Control: Quality Control Software for MaxQuant Results
This article is part of the Large-Scale Computational Mass Spectrometry and Multi-Omics special issue.
Open Access Through ACS Editors’ Choice

J. Proteome Res., 2016, 15 (3), pp 777–787
DOI: 10.1021/acs.jproteome.5b00780

Unbiased Metabolomic Investigation of Alzheimer’s Disease Brain Points to Dysregulation of Mitochondrial Aspartate Metabolism
Open Access Through ACS AuthorChoice

J. Proteome Res., 2016, 15 (2), pp 608–618
DOI: 10.1021/acs.jproteome.5b01020

A Proteomics Approach to the Protein Normalization Problem: Selection of Unvarying Proteins for MS-Based Proteomics and Western Blotting
Open Access Through ACS AuthorChoice

J. Proteome Res., 2016, 15 (7), pp 2321–2326
DOI: 10.1021/acs.jproteome.6b00403

Accounting for the Multiple Natures of Missing Values in Label-Free Quantitative Proteomics Data Sets to Compare Imputation Strategies
Open Access Through ACS AuthorChoice

J. Proteome Res., 2016, 15 (4), pp 1116–1125
DOI: 10.1021/acs.jproteome.5b00981

moCluster: Identifying Joint Patterns Across Multiple Omics Data Sets
This article is part of the Large-Scale Computational Mass Spectrometry and Multi-Omics special issue.
Open Access Through ACS Editors’ Choice

J. Proteome Res., 2016, 15 (3), pp 755–765
DOI: 10.1021/acs.jproteome.5b00824
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Molecular Pharmaceutics

Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic Data
Open Access Through ACS Editors’ Choice


Mol. Pharmaceutics, 2016, 13 (7), pp 2524–2530
DOI: 10.1021/acs.molpharmaceut.6b00248

Applications of Deep Learning in Biomedicine

Mol. Pharmaceutics, 2016, 13 (5), pp 1445–1454
DOI: 10.1021/acs.molpharmaceut.5b00982

In Vitro and in Vivo Characterization of MOD-4023, a Long-Acting Carboxy-Terminal Peptide (CTP)-Modified Human Growth Hormone
Open Access Through ACS Editors’ Choice


Mol. Pharmaceutics, 2016, 13 (2), pp 631–639
DOI: 10.1021/acs.molpharmaceut.5b00868

Light Control of Insulin Release and Blood Glucose Using an Injectable Photoactivated Depot
Open Access Through ACS Editors’ Choice


Mol. Pharmaceutics, 2016, 13 (11), pp 3835–3841
DOI: 10.1021/acs.molpharmaceut.6b00633

Molecular Imaging of Pancreatic Cancer with Antibodies
Open Access Through ACS AuthorChoice


Mol. Pharmaceutics, 2016, 13 (1), pp 8–24
DOI: 10.1021/acs.molpharmaceut.5b00626

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Read more most-read articles: Analytical | Applied | Materials Science & Engineering | Organic/Inorganic | Physical

Most-Read Articles of 2016: Applied Chemistry

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in 2016, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list for 2016, but rather as an interesting perspective on where the chemistry community allocated their attention over the past year.

Of course, certain factors such as publishing earlier in the year, being featured in a special issue or being made open access may influence which items appeared on this list. To that end, ACS Axial will be publishing monthly updates on the most read chemistry articles of 2017 all year long. Don’t see your favorite papers on the list? Feel free to share your picks in the comments below.

Read more most-read articles: Analytical | Biological | Materials Science & Engineering | Organic/Inorganic | Physical
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ACS Applied Materials & Interfaces

Coupling Hollow Fe3O4–Fe Nanoparticles with Graphene Sheets for High-Performance Electromagnetic Wave Absorbing Material

ACS Appl. Mater. Interfaces, 2016, 8 (6), pp 3730–3735
DOI: 10.1021/acsami.5b12789

Fabrication and Enhanced Photoelectrochemical Performance of MoS2/S-Doped g-C3N4 Heterojunction Film

ACS Appl. Mater. Interfaces, 2016, 8 (8), pp 5280–5289
DOI: 10.1021/acsami.5b11326

One-Step Synthesis of Water-Soluble MoS2 Quantum Dots via a Hydrothermal Method as a Fluorescent Probe for Hyaluronidase Detection

ACS Appl. Mater. Interfaces, 2016, 8 (18), pp 11272–11279
DOI: 10.1021/acsami.6b01166

Electrochemistry of Carbon Dioxide on Carbon Electrodes

ACS Appl. Mater. Interfaces, 2016, 8 (42), pp 28357–28371
DOI: 10.1021/acsami.5b09825

Cobalt Phosphide Hollow Polyhedron as Efficient Bifunctional Electrocatalysts for the Evolution Reaction of Hydrogen and Oxygen

ACS Appl. Mater. Interfaces, 2016, 8 (3), pp 2158–2165
DOI: 10.1021/acsami.5b10727
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ACS Biomaterials Science & Engineering

Designing Biomaterials for 3D Printing
This article is part of the 3D Bioprinting special issue.

ACS Biomater. Sci. Eng., 2016, 2 (10), pp 1679–1693
DOI: 10.1021/acsbiomaterials.6b00121

3D Printing PDMS Elastomer in a Hydrophilic Support Bath via Freeform Reversible Embedding
This article is part of the 3D Bioprinting special issue.
Open Access Through ACS AuthorChoice

ACS Biomater. Sci. Eng., 2016, 2 (10), pp 1781–1786
DOI: 10.1021/acsbiomaterials.6b00170

Liquid-like Solids Support Cells in 3D
This article is part of the 3D Bioprinting special issue.
Open Access Through ACS Editors’ Choice

ACS Biomater. Sci. Eng., 2016, 2 (10), pp 1787–1795
DOI: 10.1021/acsbiomaterials.6b00218

Critical Length of PEG Grafts on lPEI/DNA Nanoparticles for Efficient in Vivo Delivery
Open Access Through ACS Editors’ Choice

ACS Biomater. Sci. Eng., 2016, 2 (4), pp 567–578
DOI: 10.1021/acsbiomaterials.5b00551

Polymeric Biomaterials for Medical Implants and Devices

ACS Biomater. Sci. Eng., 2016, 2 (4), pp 454–472
DOI: 10.1021/acsbiomaterials.5b00429
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ACS Combinatorial Science

CuAAC: An Efficient Click Chemistry Reaction on Solid Phase

ACS Comb. Sci., 2016, 18 (1), pp 1–14
DOI: 10.1021/acscombsci.5b00087

Discovery of a Direct Ras Inhibitor by Screening a Combinatorial Library of Cell-Permeable Bicyclic Peptides
Open Access Through ACS Editors’ Choice

ACS Comb. Sci., 2016, 18 (1), pp 75–85
DOI: 10.1021/acscombsci.5b00164

Rapid Discovery of Functional Small Molecule Ligands against Proteomic Targets through Library-Against-Library Screening
Open Access Through ACS Editors’ Choice

ACS Comb. Sci., 2016, 18 (6), pp 320–329
DOI: 10.1021/acscombsci.5b00194

Direct Phenotypic Screening in Mice: Identification of Individual, Novel Antinociceptive Compounds from a Library of 734 821 Pyrrolidine Bis-piperazines
Open Access Through ACS Editors’ Choice

ACS Comb. Sci., 2016, 18 (1), pp 51–64
DOI: 10.1021/acscombsci.5b00126

Simulated Screens of DNA Encoded Libraries: The Potential Influence of Chemical Synthesis Fidelity on Interpretation of Structure–Activity Relationships

ACS Comb. Sci., 2016, 18 (7), pp 415–424
DOI: 10.1021/acscombsci.6b00001

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ACS Energy Letters

100k Cycles and Beyond: Extraordinary Cycle Stability for MnO2 Nanowires Imparted by a Gel Electrolyte

ACS Energy Lett., 2016, 1 (1), pp 57–63
DOI: 10.1021/acsenergylett.6b00029

Perovskite Solar Cells Shine in the “Valley of the Sun”

ACS Energy Lett., 2016, 1 (1), pp 64–67
DOI: 10.1021/acsenergylett.6b00069

Formamidinium Lead Halide Perovskite Crystals with Unprecedented Long Carrier Dynamics and Diffusion Length

ACS Energy Lett., 2016, 1 (1), pp 32–37
DOI: 10.1021/acsenergylett.6b00002

Toward Lead-Free Perovskite Solar Cells
Open Access Through ACS Editors’ Choice

ACS Energy Lett., 2016, 1 (6), pp 1233–1240
DOI: 10.1021/acsenergylett.6b00499

High-Energy-Density Lithium–Sulfur Batteries Based on Blade-Cast Pure Sulfur Electrodes

ACS Energy Lett., 2016, 1 (1), pp 46–51
DOI: 10.1021/acsenergylett.6b0003333
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ACS Infectious Diseases

Zika Virus: Diagnosis, Therapeutics, and Vaccine
Open Access Through ACS Editors’ Choice
ACS Infect. Dis., 2016, 2 (3), pp 170–172
DOI: 10.1021/acsinfecdis.6b00030

Zika Virus Genomic RNA Possesses Conserved G-Quadruplexes Characteristic of the Flaviviridae Family
Open Access Through ACS Editors’ Choice

ACS Infect. Dis., 2016, 2 (10), pp 674–681
DOI: 10.1021/acsinfecdis.6b00109

Dipeptide-Based Metabolic Labeling of Bacterial Cells for Endogenous Antibody Recruitment
Open Access Through ACS Editors’ Choice

ACS Infect. Dis., 2016, 2 (4), pp 302–309
DOI: 10.1021/acsinfecdis.6b00007

A Small-Molecule Screening Platform for the Discovery of Inhibitors of Undecaprenyl Diphosphate Synthase
Open Access Through ACS Editors’ Choice

ACS Infect. Dis., 2016, 2 (7), pp 489–499
DOI: 10.1021/acsinfecdis.6b00044

De Novo Sequencing and Resurrection of a Human Astrovirus-Neutralizing Antibody
Open Access Through ACS Editors’ Choice

ACS Infect. Dis., 2016, 2 (5), pp 313–321
DOI: 10.1021/acsinfecdis.6b00026

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ACS Medicinal Chemistry Letters

Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR
Open Access Through ACS Editors’ Choice

ACS Med. Chem. Lett., 2016, 7 (4), pp 351–356
DOI: 10.1021/acsmedchemlett.6b00005

Hope and Disappointment: Covalent Inhibitors to Overcome Drug Resistance in Non-Small Cell Lung Cancer

ACS Med. Chem. Lett., 2016, 7 (1), pp 2–5
DOI: 10.1021/acsmedchemlett.5b00475

Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism
Open Access Through ACS Editors’ Choice

ACS Med. Chem. Lett., 2016, 7 (11), pp 977–982
DOI: 10.1021/acsmedchemlett.6b00195

High Drug Prices Hurt Everyone

ACS Med. Chem. Lett., 2016, 7 (6), pp 544–546
DOI: 10.1021/acsmedchemlett.6b00139

GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain
Open Access Through ACS Editors’ Choice

ACS Med. Chem. Lett., 2016, 7 (6), pp 552–557
DOI: 10.1021/acsmedchemlett.6b00092
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ACS Sensors

Biosensors Based on Two-Dimensional MoS2

ACS Sens., 2016, 1 (1), pp 5–16
DOI: 10.1021/acssensors.5b00142

Aptamer-Modified Graphene-Based Catalytic Micromotors: Off–On Fluorescent Detection of Ricin
(Open Access Through ACS Editors’ Choice)

ACS Sens., 2016, 1 (3), pp 217–221
DOI: 10.1021/acssensors.5b00300

Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids
(Open Access Through ACS Editors’ Choice)

ACS Sens., 2016, 1 (7), pp 866–874
DOI: 10.1021/acssensors.6b00287

Noninvasive Alcohol Monitoring Using a Wearable Tattoo-Based Iontophoretic-Biosensing System

ACS Sens., 2016, 1 (8), pp 1011–1019
DOI: 10.1021/acssensors.6b00356

Wearable Chemical Sensors: Present Challenges and Future Prospects

ACS Sens., 2016, 1 (5), pp 464–482
DOI: 10.1021/acssensors.6b00250

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ACS Sustainable Chemistry & Engineering

Spent Coffee Bioelastomeric Composite Foams for the Removal of Pb2+ and Hg2+ from Water

ACS Sustainable Chem. Eng., 2016, 4 (10), pp 5495–5502
DOI: 10.1021/acssuschemeng.6b01098

Total Utilization of Miscanthus Biomass, Lignin and Carbohydrates, Using Earth Abundant Nickel Catalyst
(Open Access Through ACS Editors’ Choice)

ACS Sustainable Chem. Eng., 2016, 4 (4), pp 2316–2322
DOI: 10.1021/acssuschemeng.5b01776

Base-Catalyzed Depolymerization of Biorefinery Lignins
(Open Access Through ACS Editors’ Choice)

ACS Sustainable Chem. Eng., 2016, 4 (3), pp 1474–1486
DOI: 10.1021/acssuschemeng.5b01451

Transformation of Chitin and Waste Shrimp Shells into Acetic Acid and Pyrrole
(Open Access Through ACS Editors’ Choice)

ACS Sustainable Chem. Eng., 2016, 4 (7), pp 3912–3920
DOI: 10.1021/acssuschemeng.6b00767

Depolymerization of Cellulose in Water Catalyzed by Phenylboronic Acid Derivatives
(Open Access Through ACS Editors’ Choice)

ACS Sustainable Chem. Eng., 2016, 4 (10), pp 5799–5803
DOI: 10.1021/acssuschemeng.6b01071
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ACS Synthetic Biology

Synthetic RNA Polymerase III Promoters Facilitate High-Efficiency CRISPR–Cas9-Mediated Genome Editing in Yarrowia lipolytica
Open Access Through ACS AuthorChoice

ACS Synth. Biol., 2016, 5 (4), pp 356–359
DOI: 10.1021/acssynbio.5b00162

Corynebacterium glutamicum Metabolic Engineering with CRISPR Interference (CRISPRi)
Open Access Through ACS AuthorChoice

ACS Synth. Biol., 2016, 5 (5), pp 375–385
DOI: 10.1021/acssynbio.5b00216

Rapid and Efficient One-Step Metabolic Pathway Integration in E. coli

ACS Synth. Biol., 2016, 5 (7), pp 561–568
DOI: 10.1021/acssynbio.5b00187

Cell–Cell Communication in Yeast Using Auxin Biosynthesis and Auxin Responsive CRISPR Transcription Factors

ACS Synth. Biol., 2016, 5 (4), pp 279–286
DOI: 10.1021/acssynbio.5b00064

Multiple Gene Repression in Cyanobacteria Using CRISPRi

ACS Synth. Biol., 2016, 5 (3), pp 207–212
DOI: 10.1021/acssynbio.5b00264

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Analytical Chemistry

Instrument-Free Point-of-Care Molecular Detection of Zika Virus
(Open Access Through ACS Editors’ Choice)

Anal. Chem., 2016, 88 (14), pp 7289–7294
DOI: 10.1021/acs.analchem.6b01632

Hard Cap Espresso Machines in Analytical Chemistry: What Else?
Open Access Through ACS AuthorChoice

Anal. Chem., 2016, 88 (12), pp 6570–6576
DOI: 10.1021/acs.analchem.6b01400

Fluorescence, Phosphorescence, and Chemiluminescence
This article is part of the Fundamental and Applied Reviews in Analytical Chemistry 2016 special issue.

Anal. Chem., 2016, 88 (1), pp 170–202
DOI: 10.1021/acs.analchem.5b04109

Toward Merging Untargeted and Targeted Methods in Mass Spectrometry-Based Metabolomics and Lipidomics
This article is part of the Fundamental and Applied Reviews in Analytical Chemistry 2016 special issue.

Anal. Chem., 2016, 88 (1), pp 524–545
DOI: 10.1021/acs.analchem.5b04491

Lab-on-a-Drone: Toward Pinpoint Deployment of Smartphone-Enabled Nucleic Acid-Based Diagnostics for Mobile Health Care
Open Access Through ACS Editors’ Choice

Anal. Chem., 2016, 88 (9), pp 4651–4660
DOI: 10.1021/acs.analchem.5b04153

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Chemical Research in Toxicology

Chemical Composition of Aerosol from an E-Cigarette: A Quantitative Comparison with Cigarette Smoke
Open Access Through ACS AuthorChoice

Chem. Res. Toxicol., 2016, 29 (10), pp 1662–1678
DOI: 10.1021/acs.chemrestox.6b00188

Computational Models for Human and Animal Hepatotoxicity with a Global Application Scope
Open Access Through ACS Editors’ Choice

Chem. Res. Toxicol., 2016, 29 (5), pp 757–767
DOI: 10.1021/acs.chemrestox.5b00465

Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space
This article is part of the Toxicology Strategies for Drug Discovery – Present and Future special issue.

Chem. Res. Toxicol., 2016, 29 (4), pp 564–616
DOI: 10.1021/acs.chemrestox.6b00043

Hop (Humulus lupulus L.) Extract and 6-Prenylnaringenin Induce P450 1A1 Catalyzed Estrogen 2-Hydroxylation
Open Access Through ACS Editors’ Choice

Chem. Res. Toxicol., 2016, 29 (7), pp 1142–1150
DOI: 10.1021/acs.chemrestox.6b00112

Metabolic Fate of Hallucinogenic NBOMes
Open Access Through ACS AuthorChoice

Chem. Res. Toxicol., 2016, 29 (1), pp 96–100
DOI: 10.1021/acs.chemrestox.5b00450

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Crystal Growth & Design

Solvates, Salts, and Cocrystals: A Proposal for a Feasible Classification System
Open Access Through ACS Editors’ Choice

Cryst. Growth Des., 2016, 16 (6), pp 3237–3243
DOI: 10.1021/acs.cgd.6b00200

It Isn’t, It Is: The C–H···X (X = O, N, F, Cl) Interaction Really Is Significant in Crystal Packing
Open Access Through ACS Editors’ Choice

Cryst. Growth Des., 2016, 16 (8), pp 4165–4168
DOI: 10.1021/acs.cgd.6b00736

How Surfactants Control Crystal Growth of Nanomaterials

Cryst. Growth Des., 2016, 16 (2), pp 1104–1133
DOI: 10.1021/acs.cgd.5b01465

Ion-Directed Synthesis of Indium-Derived 2,5-Thiophenedicarboxylate Metal–Organic Frameworks: Tuning Framework Dimensionality
Open Access Through ACS Editors’ Choice

Cryst. Growth Des., 2016, 16 (3), pp 1550–1558
DOI: 10.1021/acs.cgd.5b01680

Molecular Interactions in Crystal Structures with Z′ > 1
Open Access Through ACS Editors’ Choice

Cryst. Growth Des., 2016, 16 (5), pp 2988–3001
DOI: 10.1021/acs.cgd.6b00355

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Energy & Fuels

Role of Asphaltenes and Additives on the Viscosity and Microscopic Structure of Heavy Crude Oils
This article is part of the 16th International Conference on Petroleum Phase Behavior and Fouling special issue.

Energy Fuels, 2016, 30 (5), pp 3644–3651
DOI: 10.1021/acs.energyfuels.5b02103

Pyrolysis Oil Multiphase Behavior and Phase Stability: A Review

Energy Fuels, 2016, 30 (8), pp 6179–6200
DOI: 10.1021/acs.energyfuels.6b01287

CO2 Reaction Mechanisms with Hindered Alkanolamines: Control and Promotion of Reaction Pathways

Energy Fuels, 2016, 30 (2), pp 1223–1236
DOI: 10.1021/acs.energyfuels.5b02582

Review of NMR Characterization of Pyrolysis Oils

Energy Fuels, 2016, 30 (9), pp 6863–6880
DOI: 10.1021/acs.energyfuels.6b01002

Proton Conducting Nafion-Sulfonated Graphene Hybrid Membranes for Direct Methanol Fuel Cells with Reduced Methanol Crossover

Energy Fuels, 2016, 30 (1), pp 725–734
DOI: 10.1021/acs.energyfuels.5b02194
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Environmental Science & Technology

Emissions of Ultrafine Particles and Volatile Organic Compounds from Commercially Available Desktop Three-Dimensional Printers with Multiple Filaments
Open Access Through ACS AuthorChoice

Environ. Sci. Technol., 2016, 50 (3), pp 1260–1268
DOI: 10.1021/acs.est.5b04983

Plastic Debris Is a Human Health Issue
Environ. Sci. Technol., 2016, 50 (13), pp 6825–6826
DOI: 10.1021/acs.est.6b02569

Regional Effects of Agricultural Conservation Practices on Nutrient Transport in the Upper Mississippi River Basin
Open Access Through ACS AuthorChoice

Environ. Sci. Technol., 2016, 50 (13), pp 6991–7000
DOI: 10.1021/acs.est.5b03543

Personal Vehicles Evaluated against Climate Change Mitigation Targets
Open Access Through ACS AuthorChoice

Environ. Sci. Technol., 2016, 50 (20), pp 10795–10804
DOI: 10.1021/acs.est.6b00177

Progressive Increase in Disinfection Byproducts and Mutagenicity from Source to Tap to Swimming Pool and Spa Water: Impact of Human Inputs

Environ. Sci. Technol., 2016, 50 (13), pp 6652–6662
DOI: 10.1021/acs.est.6b00808

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Environmental Science & Technology Letters

Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants
Open Access Through ACS Editors’ Choice

Environ. Sci. Technol. Lett., 2016, 3 (10), pp 344–350
DOI: 10.1021/acs.estlett.6b00260

Toward Microcapsule-Embedded Self-Healing Membranes
Open Access Through ACS Editors’ Choice

Environ. Sci. Technol. Lett., 2016, 3 (5), pp 216–221
DOI: 10.1021/acs.estlett.6b00046

Origin of Hexavalent Chromium in Drinking Water Wells from the Piedmont Aquifers of North Carolina
Open Access Through ACS Editors’ Choice

Environ. Sci. Technol. Lett., 2016, 3 (12), pp 409–414
DOI: 10.1021/acs.estlett.6b00342

Metformin and Other Pharmaceuticals Widespread in Wadeable Streams of the Southeastern United States
Open Access Through ACS AuthorChoice

Environ. Sci. Technol. Lett., 2016, 3 (6), pp 243–249
DOI: 10.1021/acs.estlett.6b00170

The Critical Need for Increased Selectivity, Not Increased Water Permeability, for Desalination Membranes
Open Access Through ACS AuthorChoice

Environ. Sci. Technol. Lett., 2016, 3 (4), pp 112–120
DOI: 10.1021/acs.estlett.6b00050

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Industrial & Engineering Chemistry Research

Toward the Development and Deployment of Large-Scale Carbon Dioxide Capture and Conversion Processes
Open Access Through ACS Editors’ Choice

Ind. Eng. Chem. Res., 2016, 55 (12), pp 3383–3419
DOI: 10.1021/acs.iecr.5b03277

Modeling and Dynamic Optimization of Microalgae Cultivation in Outdoor Open Ponds
Open Access Through ACS Editors’ Choice

Ind. Eng. Chem. Res., 2016, 55 (12), pp 3327–3337
DOI: 10.1021/acs.iecr.5b03209

Limitations of Breakthrough Curve Analysis in Fixed-Bed Adsorption
Open Access Through ACS Editors’ Choice

Ind. Eng. Chem. Res., 2016, 55 (16), pp 4734–4748
DOI: 10.1021/acs.iecr.6b00516

Solvent-Based Exfoliation via Sonication of Graphitic Materials for Graphene Manufacture

Ind. Eng. Chem. Res., 2016, 55 (4), pp 845–855
DOI: 10.1021/acs.iecr.5b03502

Recent Advancement of Coagulation–Flocculation and Its Application in Wastewater Treatment

Ind. Eng. Chem. Res., 2016, 55 (16), pp 4363–4389
DOI: 10.1021/acs.iecr.5b04703

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Journal of Agricultural and Food Chemistry

Determination of Glyphosate Levels in Breast Milk Samples from Germany by LC-MS/MS and GC-MS/MS
Open Access Through ACS AuthorChoice

J. Agric. Food Chem., 2016, 64 (6), pp 1414–1421
DOI: 10.1021/acs.jafc.5b05852

Antioxidant Mechanism of Betaine without Free Radical Scavenging Ability
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J. Agric. Food Chem., 2016, 64 (42), pp 7921–7930
DOI: 10.1021/acs.jafc.6b03592

Nanoencapsulation, Nano-guard for Pesticides: A New Window for Safe Application

J. Agric. Food Chem., 2016, 64 (7), pp 1447–1483
DOI: 10.1021/acs.jafc.5b05214

Sulfoglucosides as Novel Modified Forms of the Mycotoxins Alternariol and Alternariol Monomethyl Ether
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J. Agric. Food Chem., 2016, 64 (46), pp 8892–8901
DOI: 10.1021/acs.jafc.6b03120

Global Adoption of Genetically Modified (GM) Crops: Challenges for the Public Sector

J. Agric. Food Chem., 2016, 64 (2), pp 394–402
DOI: 10.1021/acs.jafc.5b05116

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Journal of Chemical & Engineering Data

Investigation of Binary Mixtures Containing 1-Ethyl-3-methylimidazolium Bis(trifluoromethanesulfonyl)azanide and Ethylene Carbonate
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J. Chem. Eng. Data, 2016, 61 (1), pp 114–123
DOI: 10.1021/acs.jced.5b00338

Target Synthesis of an Azo (N═N) Based Covalent Organic Framework with High CO2-over-N2 Selectivity and Benign Gas Storage Capability

J. Chem. Eng. Data, 2016, 61 (5), pp 1904–1909
DOI: 10.1021/acs.jced.6b00071

Comparison of Ionic Liquids to Conventional Organic Solvents for Extraction of Aromatics from Aliphatics

J. Chem. Eng. Data, 2016, 61 (5), pp 1685–1699
DOI: 10.1021/acs.jced.6b00077

Density, Viscosity, and Refractive Index of Ionic Liquid Mixtures Containing Cyano and Amino Acid-Based Anions

J. Chem. Eng. Data, 2016, 61 (1), pp 83–93
DOI: 10.1021/acs.jced.5b00242

Adsorption Equilibria of Water Vapor on Zeolite 3A, Zeolite 13X, and Dealuminated Y Zeolite

J. Chem. Eng. Data, 2016, 61 (4), pp 1547–1554
DOI: 10.1021/acs.jced.5b00927

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Journal of Chemical Education

Strategies of Successful Synthesis Solutions: Mapping, Mechanisms, and More
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J. Chem. Educ., 2016, 93 (4), pp 593–604
DOI: 10.1021/acs.jchemed.5b00900

Investigating Students’ Reasoning about Acid–Base Reactions
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J. Chem. Educ., 2016, 93 (10), pp 1703–1712
DOI: 10.1021/acs.jchemed.6b00417

Deducing Reaction Mechanism: A Guide for Students, Researchers, and Instructors

J. Chem. Educ., 2016, 93 (2), pp 275–286
DOI: 10.1021/acs.jchemed.5b00160

Building a Microcontroller Based Potentiostat: A Inexpensive and Versatile Platform for Teaching Electrochemistry and Instrumentation

J. Chem. Educ., 2016, 93 (7), pp 1320–1322
DOI: 10.1021/acs.jchemed.5b00961

RCSB Protein Data Bank: A Resource for Chemical, Biochemical, and Structural Explorations of Large and Small Biomolecules
This article is part of the Chemical Information special issue.

J. Chem. Educ., 2016, 93 (3), pp 569–575
DOI: 10.1021/acs.jchemed.5b00404

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Journal of Chemical Information and Modeling

The Proximal Lilly Collection: Mapping, Exploring and Exploiting Feasible Chemical Space
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J. Chem. Inf. Model., 2016, 56 (7), pp 1253–1266
DOI: 10.1021/acs.jcim.6b00173

Experimental and Chemoinformatics Study of Tautomerism in a Database of Commercially Available Screening Samples
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J. Chem. Inf. Model., 2016, 56 (11), pp 2149–2161
DOI: 10.1021/acs.jcim.6b00338

Ultra-High-Throughput Structure-Based Virtual Screening for Small-Molecule Inhibitors of Protein–Protein Interactions

J. Chem. Inf. Model., 2016, 56 (2), pp 399–411
DOI: 10.1021/acs.jcim.5b00572

Understanding the Roles of the “Two QSARs”


J. Chem. Inf. Model., 2016, 56 (2), pp 269–274
DOI: 10.1021/acs.jcim.5b00229

Blind Pose Prediction, Scoring, and Affinity Ranking of the CSAR 2014 Dataset
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This article is part of the Community Structure Activity Resource (CSAR) special issue.


J. Chem. Inf. Model., 2016, 56 (6), pp 996–1003
DOI: 10.1021/acs.jcim.5b00337
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Journal of Chemical Theory and Computation

CHARMM-GUI Input Generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM Simulations Using the CHARMM36 Additive Force Field
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J. Chem. Theory Comput., 2016, 12 (1), pp 405–413
DOI: 10.1021/acs.jctc.5b00935

Demonstrating an Order-of-Magnitude Sampling Enhancement in Molecular Dynamics Simulations of Complex Protein Systems

J. Chem. Theory Comput., 2016, 12 (3), pp 1360–1367
DOI: 10.1021/acs.jctc.5b00913

A Practical Guide to Density Matrix Embedding Theory in Quantum Chemistry
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J. Chem. Theory Comput., 2016, 12 (6), pp 2706–2719
DOI: 10.1021/acs.jctc.6b00316

OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins

J. Chem. Theory Comput., 2016, 12 (1), pp 281–296
DOI: 10.1021/acs.jctc.5b00864

Black-Box Description of Electron Correlation with the Spin-Extended Configuration Interaction Model: Implementation and Assessment

J. Chem. Theory Comput., 2016, 12 (4), pp 1741–1759
DOI: 10.1021/acs.jctc.6b00137

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Journal of Medicinal Chemistry

Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis
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J. Med. Chem., 2016, 59 (13), pp 6027–6044
DOI: 10.1021/acs.jmedchem.5b01833

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
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J. Med. Chem., 2016, 59 (10), pp 4443–4458
DOI: 10.1021/acs.jmedchem.5b01409

AXL Inhibitors in Cancer: A Medicinal Chemistry Perspective


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J. Med. Chem., 2016, 59 (8), pp 3593–3608
DOI: 10.1021/acs.jmedchem.5b01273

The Medicinal Chemistry of Dengue Virus
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J. Med. Chem., 2016, 59 (12), pp 5622–5649
DOI: 10.1021/acs.jmedchem.5b01653

A Real-World Perspective on Molecular Design
This article is part of the Computational Methods for Medicinal Chemistry special issue.


J. Med. Chem., 2016, 59 (9), pp 4087–4102
DOI: 10.1021/acs.jmedchem.5b01875

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The Journal of Physical Chemistry A

New Approach for Investigating Reaction Dynamics and Rates with Ab Initio Calculations
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J. Phys. Chem. A, 2016, 120 (2), pp 299–305
DOI: 10.1021/acs.jpca.5b10667

How to Compute Electron Ionization Mass Spectra from First Principles
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J. Phys. Chem. A, 2016, 120 (21), pp 3755–3766
DOI: 10.1021/acs.jpca.6b02907

Aqueous Photochemistry of Glyoxylic Acid
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J. Phys. Chem. A, 2016, 120 (21), pp 3817–3826
DOI: 10.1021/acs.jpca.6b00225

Semiempirical Modeling of Ag Nanoclusters: New Parameters for Optical Property Studies Enable Determination of Double Excitation Contributions to Plasmonic Excitation
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J. Phys. Chem. A, 2016, 120 (26), pp 4542–4549
DOI: 10.1021/acs.jpca.6b04520

Rotational Spectrum and Structure of the 1,1-Difluoroethylene···Carbon Dioxide Complex
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J. Phys. Chem. A, 2016, 120 (2), pp 247–253
DOI: 10.1021/acs.jpca.5b11345
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The Journal of Physical Chemistry B

Molecular Modeling of Water Interfaces: From Molecular Spectroscopy to Thermodynamics
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J. Phys. Chem. B, 2016, 120 (16), pp 3785–3796
DOI: 10.1021/acs.jpcb.6b01012

Statistical Analyses of Hydrophobic Interactions: A Mini-Review
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J. Phys. Chem. B, 2016, 120 (27), pp 6455–6460
DOI: 10.1021/acs.jpcb.6b04082

Exploring the Dependence of QM/MM Calculations of Enzyme Catalysis on the Size of the QM Region
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J. Phys. Chem. B, 2016, 120 (37), pp 9913–9921
DOI: 10.1021/acs.jpcb.6b07203

How Large Should the QM Region Be in QM/MM Calculations? The Case of Catechol O-Methyltransferase
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J. Phys. Chem. B, 2016, 120 (44), pp 11381–11394
DOI: 10.1021/acs.jpcb.6b07814

Advanced Potential Energy Surfaces for Molecular Simulation

J. Phys. Chem. B, 2016, 120 (37), pp 9811–9832
DOI: 10.1021/acs.jpcb.6b06414
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The Journal of Physical Chemistry C

Recent Progress in Cancer Thermal Therapy Using Gold Nanoparticles


J. Phys. Chem. C, 2016, 120 (9), pp 4691–4716
DOI: 10.1021/acs.jpcc.5b11232

Flexible Graphene-Based Supercapacitors: A Review


J. Phys. Chem. C, 2016, 120 (8), pp 4153–4172
DOI: 10.1021/acs.jpcc.5b10187

Introducing Cu2O Thin Films as a Hole-Transport Layer in Efficient Planar Perovskite Solar Cell Structures
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J. Phys. Chem. C, 2016, 120 (3), pp 1428–1437
DOI: 10.1021/acs.jpcc.5b11540

Potential Application of Metal Dichalcogenides Double-Layered Heterostructures as Anode Materials for Li-Ion Batteries
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J. Phys. Chem. C, 2016, 120 (9), pp 4779–4788
DOI: 10.1021/acs.jpcc.5b11677

Understanding Particle-Size-Dependent Electrochemical Properties of Li2MnO3-Based Positive Electrode Materials for Rechargeable Lithium Batteries
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J. Phys. Chem. C, 2016, 120 (2), pp 875–885
DOI: 10.1021/acs.jpcc.5b10517
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The Journal of Physical Chemistry Letters

Cesium Lead Halide Perovskites with Improved Stability for Tandem Solar Cells

J. Phys. Chem. Lett., 2016, 7 (5), pp 746–751
DOI: 10.1021/acs.jpclett.6b00002

Surface- and Tip-Enhanced Raman Spectroscopy in Catalysis
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J. Phys. Chem. Lett., 2016, 7 (8), pp 1570–1584
DOI: 10.1021/acs.jpclett.6b00147

Efficient Monolithic Perovskite/Silicon Tandem Solar Cell with Cell Area >1 cm2

J. Phys. Chem. Lett., 2016, 7 (1), pp 161–166
DOI: 10.1021/acs.jpclett.5b02686

Origin of J–V Hysteresis in Perovskite Solar Cells

J. Phys. Chem. Lett., 2016, 7 (5), pp 905–917
DOI: 10.1021/acs.jpclett.6b00215

Lead-Free Halide Double Perovskites via Heterovalent Substitution of Noble Metals

J. Phys. Chem. Lett., 2016, 7 (7), pp 1254–1259
DOI: 10.1021/acs.jpclett.6b00376
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Journal of Proteome Research

Proteomics Quality Control: Quality Control Software for MaxQuant Results
This article is part of the Large-Scale Computational Mass Spectrometry and Multi-Omics special issue.
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J. Proteome Res., 2016, 15 (3), pp 777–787
DOI: 10.1021/acs.jproteome.5b00780

Unbiased Metabolomic Investigation of Alzheimer’s Disease Brain Points to Dysregulation of Mitochondrial Aspartate Metabolism
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J. Proteome Res., 2016, 15 (2), pp 608–618
DOI: 10.1021/acs.jproteome.5b01020

A Proteomics Approach to the Protein Normalization Problem: Selection of Unvarying Proteins for MS-Based Proteomics and Western Blotting
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J. Proteome Res., 2016, 15 (7), pp 2321–2326
DOI: 10.1021/acs.jproteome.6b00403

Accounting for the Multiple Natures of Missing Values in Label-Free Quantitative Proteomics Data Sets to Compare Imputation Strategies
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J. Proteome Res., 2016, 15 (4), pp 1116–1125
DOI: 10.1021/acs.jproteome.5b00981

moCluster: Identifying Joint Patterns Across Multiple Omics Data Sets
This article is part of the Large-Scale Computational Mass Spectrometry and Multi-Omics special issue.
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J. Proteome Res., 2016, 15 (3), pp 755–765
DOI: 10.1021/acs.jproteome.5b00824
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Molecular Pharmaceutics

Deep Learning Applications for Predicting Pharmacological Properties of Drugs and Drug Repurposing Using Transcriptomic Data
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Mol. Pharmaceutics, 2016, 13 (7), pp 2524–2530
DOI: 10.1021/acs.molpharmaceut.6b00248

Applications of Deep Learning in Biomedicine

Mol. Pharmaceutics, 2016, 13 (5), pp 1445–1454
DOI: 10.1021/acs.molpharmaceut.5b00982

In Vitro and in Vivo Characterization of MOD-4023, a Long-Acting Carboxy-Terminal Peptide (CTP)-Modified Human Growth Hormone
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Mol. Pharmaceutics, 2016, 13 (2), pp 631–639
DOI: 10.1021/acs.molpharmaceut.5b00868

Light Control of Insulin Release and Blood Glucose Using an Injectable Photoactivated Depot
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Mol. Pharmaceutics, 2016, 13 (11), pp 3835–3841
DOI: 10.1021/acs.molpharmaceut.6b00633

Molecular Imaging of Pancreatic Cancer with Antibodies
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Mol. Pharmaceutics, 2016, 13 (1), pp 8–24
DOI: 10.1021/acs.molpharmaceut.5b00626

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Organic Process Research & Development

NMR Chemical Shifts of Trace Impurities: Industrially Preferred Solvents Used in Process and Green Chemistry
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Org. Process Res. Dev., 2016, 20 (3), pp 661–667
DOI: 10.1021/acs.oprd.5b00417

Large-Scale Applications of Amide Coupling Reagents for the Synthesis of Pharmaceuticals

Org. Process Res. Dev., 2016, 20 (2), pp 140–177
DOI: 10.1021/op500305s

Vacuum Desiccator as a Simple, Robust, and Inexpensive NMR Tube Cleaner

Org. Process Res. Dev., 2016, 20 (2), pp 319–319
DOI: 10.1021/acs.oprd.6b00001

Flow Chemistry: Recent Developments in the Synthesis of Pharmaceutical Products
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Org. Process Res. Dev., 2016, 20 (1), pp 2–25
DOI: 10.1021/acs.oprd.5b00325

Toward a More Holistic Framework for Solvent Selection
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Org. Process Res. Dev., 2016, 20 (4), pp 760–773
DOI: 10.1021/acs.oprd.6b00015
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