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Lise Meitner and the Discovery of Nuclear Fission: Politics, Persecution, and the Prize

At present, Lise Meitner is almost as well known for not having been awarded a Nobel Prize as many actual Nobelists are for receiving one. Historians of science have studied her role in the discovery of nuclear fission. Scholars of the Nobel awards have examined the decision processes that excluded her. And in Germany especially, historians and scientists have taken an interest in Meitner’s story for what it reveals of the history and politics of her time. But studies such as these are rather recent. For some 50 years after nuclear fission was discovered in 1938, Lise Meitner’s contributions to the discovery were not acknowledged, the Nobel records were closed to scholars, and most Germans preferred not to look closely at Lise Meitner’s story because of what it reveals of the history and politics of their time.

As a result, we have parallel historical narratives of the fission discovery. In one narrative the discovery is a strictly chemical achievement: Fission was discovered in Berlin in December 1938 when the chemists Otto Hahn and Fritz Strassmann, working at the Kaiser Wilhelm Institute for Chemistry, identified barium as a product of the neutron irradiation of uranium. The chemistry narrative, reinforced by the award of the 1944 Nobel Prize in Chemistry to Hahn alone, corresponds to his own account of the discovery.

It was widely accepted for many years, during which Hahn was in the limelight, Strassmann was in his shadow, and Lise Meitner was mostly invisible. Eventually a more comprehensive narrative emerged that includes Lise Meitner, the physicist who was Hahn’s scientific partner in the institute: The discovery was the result of a four-year investigation by Hahn, Meitner, and Strassmann that involved chemistry and physics at every stage, and even after Lise Meitner was forced to flee Germany in July 1938 she continued her collaboration with her Berlin team until the moment of discovery and beyond. In this narrative, physics is as essential as chemistry and Lise Meitner is a codiscoverer of nuclear fission who is unjustly denied the recognition she was due.

In both narratives the research is fundamental, the barium finding is key, and the discovery of nuclear fission is a sensational surprise. What has been controversial, at the time and since, is the attribution—what was the scientific basis for the discovery, and who was responsible for it?

In this chapter of The Posthumous Nobel Prize in Chemistry. Volume 2. Ladies in Waiting for the Nobel Prize, Lewin Sime gives an overview of the science and the Nobel awards, always keeping in mind that this is a discovery that cannot be understood apart from its historical, political, and personal context. For the discovery took place at a time of racial persecution, forced emigration, political oppression, opportunism, and fear—conditions that directly affected the scientists involved, the authorship of their publications, and ultimately the ways in which the fission discovery was received, recognized, and remembered.

For the most part gender bias is secondary in Lise Meitner’s story, but it was never absent. The early generations of women scientists were regarded as doubly “other:” as women they were unconventional, as scientists they were exceptions in a thoroughly male domain. At the height of her successful career in Berlin, Lise Meitner had reason to think she had put that behind her, but in Swedish exile her “otherness” as a woman scientist returned, adding one more layer to her outsider status as an immigrant, refugee, and foreigner. Gender bias also lent credibility to the narrative that she had not contributed to the fission discovery.

To the extent that women scientists were not expected to be important, independent, or even scientists at all, Hahn and his associates could describe Lise Meitner as absent, marginal, misguided, even obstructive—and they could do so with impunity, aware that others would tend to accept the gender stereotype. In Germany in the postwar decades, for example, Meitner was almost always described as Hahn’s Mitarbeiterin, the term for a junior coworker or assistant, which especially angered her because it was so completely untrue, and because it was used even by physicists, such as Werner Heisenberg, who had been her colleagues when she was still in Berlin.

Hahn, of course, did not refer to Lise Meitner as his Mitarbeiterin, but he did not correct those who did. The term can be found to this day in casual histories of fission, news articles, museum displays, science textbooks, and the like, a reminder of the stubborn persistence of gendered assumptions and the difficulty—perhaps impossibility—of correcting a flawed historical narrative that was widely disseminated for many years.

Lise Meitner was never completely written out of the history of 20th century science because she was exceptionally prominent during her lifetime, and because a rich documentary record has made it possible for a new generation of scientists and scholars to bring her life and work to light. Her story shows that the history of science is inseparable from its historical, political, and social context, and that particular attention is needed when evaluating traditional histories that have disproportionately neglected women and their contributions to science.
Read the full chapter.
This post is an excerpt from Politics, Persecution, and the Prize: Lise Meitner and the Discovery of Nuclear Fission‘, The Posthumous Nobel Prize in Chemistry. Volume 2. Ladies in Waiting for the Nobel Prize.
Chapter Author: Ruth Lewin Sime
Volume Editors: Vera V. Mainz, E. Thomas Strom
Publication Date (Web): December 14, 2018
Copyright © 2018 American Chemical Society

Learn More About The Uphill Battle Women Like Lise Meitner Faced for Recognition

Spinning a Tool From a Toy

One might be tempted to judge the ubiquitous fidget spinner, twirled endlessly between the fingers of school kids, as a mere toy. However, it has an unforeseen beneficial purpose, says a team of researchers. The device can act as a makeshift centrifuge, able to separate blood plasma to 99% purity. Just a couple of flicks of the spinner were sufficient to get enough pure plasma to test for HIV.

When doctors run blood tests, they need to separate blood cells from the desired plasma. Generally, they use a centrifuge, in which high speed rotation sediments blood cells, says study author Chien-Fu Chen of the Institute of Applied Mechanics at National Taiwan University. “Although centrifuges can produce extremely pure plasma samples, these instruments are expensive and require electricity to operate, which may not be feasible in resource-limited regions of the world,” he says.

Along with colleague Chien-Cheng Chang, Chen put human blood spiked with a common HIV-1 diagnostic protein in 50 mm long plastic tubes, sealed them, and taped the tubes to each of the three spinning arms of a commercially available fidget spinner. After spinning the device for four to seven minutes, they found they were able to retrieve about 30% of the plasma out of the blood sample—with 99% purity. To see if the blood was sufficiently separated to run diagnostic tests, they ran a paper-based HIV test on the separated plasma. The test was able to pick up the target proteins. Chen noted that this makeshift centrifuge could be used to detect other diseases with plasma biomarkers as well. And if the blood is not separated enough, just give the fidget spinner another spin. The tube is transparent, he says, so you can see the separation progress easily.

“It’s wonderful for people to be thinking about these types of approaches,” says Manu Prakash, a bioengineer at Stanford University whose team developed a paper-based whirligig centrifuge that can also separate blood plasma. “They’re incredibly important to people around the world.” Every contribution to “frugal science is extremely valuable,” he adds.

The spinning speed for a fidget spinner is a bit slow, Prakash points out, which makes the total spinning time to separate blood a bit longer than with his group’s whirligig one, for instance. “But in the end, the most important thing is lighting up people’s imagination,” Prakash said. “The fact that solutions can exist in unusual places is frankly as important sometimes as the solutions themselves.”

This article is reproduced with permission from C&EN (© American Chemical Society). The article was first published on February 1, 2019.

Discover Chemistry’s Impact on Cancer Research at AACR 2019

The American Chemical Society (ACS) and ACS Publications will be in the Peach State this weekend, March 31 – April 4, 2019, for the 110th Annual AACR Meeting in Atlanta. The theme of this year’s meeting is “Integrative Cancer Science Global Impact Individualized Patient Care.” With so much of the meeting devoted to basic science discoveries, ACS Publications recognizes the value of chemistry as a foundation for progress in the field of cancer research.

Join ACS Publications at Booth 4144 to learn more about publishing with ACS journals at the interface of biology and chemistry, including  ACS Pharmacology & Translational Science, ACS Synthetic Biology, ACS Chemical Biology, Journal of Medicinal Chemistry, Biochemistry, ACS Chemical Neuroscience and more!

Here are 6 Updates from the ACS Publications Bio Portfolio:

ACS Pharmacology & Translational Science

ACS Pharmacology & Translational Science Volume 2, Issue 1, is online and free to read for a limited time courtesy of ACS Publications. Read it now. The journal wants your research on innovative research across the broad spectrum of biological sciences —from basic and molecular sciences to translational preclinical studies.

ACS Chemical Biology

Luke Wiseman, Ph.D.,  Associate Professor of the Department of Molecular Medicine at Scripps Research, will guest edit an upcoming special issue on Proteolytic Regulation of Cellular Physiology. Learn more about submitting your research for this special issue.

ACS Chemical Biology also publishes research that serves the AACR community, like this ACS Editors’ Choice article on revamping a brain cancer drug in mice. Stop by the booth to learn more about this journal and claim an exclusive t-shirt!

Bioconjugate Chemistry

The journal’s  February special issue focused on “Delivery of Proteins and Nucleic Acids: Achievements and Challenges.” Jointly guest edited by Theresa Reineke and Ronald Raines, with Vincent Rotello, Editor-in-Chief, this issue discusses the many innovative delivery approaches involving the use of synthetic conjugates, polymer carriers, peptides, and scaffolds with responsive chemistry to overcome the many biological barriers that exist.

Check out some of the research published in this issue and stop by the booth for your Bioconjugate Chemistry t-shirt!

Journal of Medicinal Chemistry

Journal of Medicinal Chemistry will be publishing a Special Issue on “Drug Metabolism and Toxicology” and is also looking for submissions. Perspectives should be submitted by May 31, 2019, and all other manuscript types should be submitted by June 30, 2019. For more information, visit the journal homepage.

Don’t miss articles published by Journal of Medicinal Chemistry related to cancer research, such as this recent article on “Novel Triapine Derivative Induces Copper-Dependent Cell Death in Hematopoietic Cancers” and “Discovery of Novel Bromophenol–Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer”.

Molecular Imaging: A Virtual issue

From live-cell microscopic technologies, such as atomic force microscopy (AFM), to full body clinical imaging technologies, such as magnetic resonance imaging (MRI) and positron emission tomography (PET), molecular imaging has led to improvements in the diagnosis and management of cancer. This virtual issue features articles from molecular imaging laboratories across the globe published in 12 various journals. Read this virtual issue now.

Publish Open Access with ACS

Maybe you need to publish your research Open Access to satisfy a funding requirement. Maybe you just want to make sure you reach a wide audience with the cancer research field. Either way, 100% of ACS journals can publish your work Open Access, and can meet even the strictest CC-BY license funding requirements.

Additionally, ACS Publications features two widely-read, fully open access journals, ACS Central Science and ACS Omega. Check out these recent cancer research articles:

Imaging Mass Spectrometry Reveals Crosstalk between the Fallopian Tube and the Ovary that Drives Primary Metastasis of Ovarian Cancer
ACS Cent. Sci., 2018, 4 (10), pp 1360–1370
DOI: 10.1021/acscentsci.8b00405

Fluorescence-Based Ratiometric Nanosensor for Selective Imaging of Cancer Cells
ACS Omega, 2019, 4 (1), pp 1592–1600
DOI: 10.1021/acsomega.8b02765

Virtual Issue: Molecular Imaging

Molecular Imaging is a relatively new biomedical research field that has gained significant traction over the last decade. Using various techniques, molecular imaging allows for the non-invasive identification, visualization, characterization, and quantification of biological processes occurring in living organisms. From live-cell microscopic technologies, such as atomic force microscopy (AFM), to full body clinical imaging technologies, such as magnetic resonance imaging (MRI) and positron emission tomography (PET), molecular imaging has led to improvements in the diagnosis and management of many diseases worldwide.

In this Virtual Issue, we are delighted to present many of the incredible ACS publications from molecular imaging laboratories across the globe, which have been published in ACS Central Science, ACS Chemical Biology, ACS Chemical Neuroscience, ACS Combinatorial Science, ACS Infectious Diseases, ACS Medicinal Chemistry Letters, ACS Nano, Biochemistry, Bioconjugate Chemistry, Journal of Medicinal Chemistry, and Molecular Pharmaceutics. We hope you enjoy reading this unique collection of Research Articles, Reviews, Perspectives, and Viewpoints.  As always, thank you for being a loyal reader of ACS Publications!


ACS Central Science
Expanding the Chemical Space of Biocompatible Fluorophores: Nanohoops in Cells
ACS Cent. Sci., 2018, 4 (9), pp 1173–1178
DOI: 10.1021/acscentsci.8b00346
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In Vivo Two-Photon Voltage Imaging with Sulfonated Rhodamine Dyes
ACS Cent. Sci., 2018, 4 (10), pp 1371–1378
DOI: 10.1021/acscentsci.8b00422
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Opening a Gateway for Chemiluminescence Cell Imaging: Distinctive Methodology for Design of Bright Chemiluminescent Dioxetane Probes
ACS Cent. Sci., 2017, 3 (4), pp 349–358
DOI: 10.1021/acscentsci.7b00058
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General Synthetic Method for Si-Fluoresceins and Si-Rhodamines
ACS Cent. Sci., 2017, 3 (9), pp 975–985
DOI: 10.1021/acscentsci.7b00247
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Close Correlation of Monoamine Oxidase Activity with Progress of Alzheimer’s Disease in Mice, Observed by in Vivo Two-Photon Imaging
ACS Cent. Sci., 2016, 2 (12), pp 967–975
DOI: 10.1021/acscentsci.6b00309

ACS Chemical Biology
Lessons Learned from Luminous Luciferins and Latent Luciferases
ACS Chem. Biol., 2018, 13 (7), pp 1734–1740
DOI: 10.1021/acschembio.7b00964
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Fluorescent Chemosensors as Future Tools for Cancer Biology
ACS Chem. Biol., 2018, 13 (7), pp 1785–1798
DOI: 10.1021/acschembio.8b00014
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Enzyme-Activated Fluorogenic Probes for Live-Cell and in Vivo Imaging
ACS Chem. Biol., 2018, 13 (7), pp 1810–1823
DOI: 10.1021/acschembio.8b00371
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Tuning the Color Palette of Fluorescent Copper Sensors through Systematic Heteroatom Substitution at Rhodol Cores
ACS Chem. Biol., 2018, 13 (7), pp 1844–1852
DOI: 10.1021/acschembio.7b00748
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Fe(II) Ion Release during Endocytotic Uptake of Iron Visualized by a Membrane-Anchoring Fe(II) Fluorescent Probe
ACS Chem. Biol., 2018, 13 (7), pp 1853–1861
DOI: 10.1021/acschembio.7b00939

ACS Chemical Neuroscience
Classics in Neuroimaging: Imaging the Dopaminergic Pathway with PET
ACS Chem. Neurosci., 2017, 8 (9), pp 1817–1819
DOI: 10.1021/acschemneuro.7b00252
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Classics in Neuroimaging: Radioligands for the Vesicular Monoamine Transporter 2
ACS Chem. Neurosci., 2019, 10 (1), pp 25–29
DOI: 10.1021/acschemneuro.8b00429
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Classics in Neuroimaging: The Serotonergic 2A Receptor System—from Discovery to Modern Molecular Imaging
ACS Chem. Neurosci., 2018, 9 (6), pp 1226–1229
DOI: 10.1021/acschemneuro.8b00176

ACS Combinatorial Science
Discrete Fourier Transform-Based Multivariate Image Analysis: Application to Modeling of Aromatase Inhibitory Activity
ACS Comb. Sci., 2018, 20 (2), pp 75–81
DOI: 10.1021/acscombsci.7b00155
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Fabrication of a New Lineage of Artificial Luciferases from Natural Luciferase Pools
ACS Comb. Sci., 2017, 19 (9), pp 594–599
DOI: 10.1021/acscombsci.7b00081
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Assembly of Macrocycle Dye Derivatives into Particles for Fluorescence and Photoacoustic Applications
ACS Comb. Sci., 2017, 19 (6), pp 397–406
DOI: 10.1021/acscombsci.7b00031
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Fluorescence Multiplexing with Spectral Imaging and Combinatorics
ACS Comb. Sci., 2018, 20 (11), pp 653–659
DOI: 10.1021/acscombsci.8b00101
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A Wide-Field Fluorescence Microscope Extension for Ultrafast Screening of One-Bead One-Compound Libraries Using a Spectral Image Subtraction Approach
ACS Comb. Sci., 2016, 18 (5), pp 209–219
DOI: 10.1021/acscombsci.5b00175

ACS Infectious Diseases
Prediction of Drug Penetration in Tuberculosis Lesions
ACS Infect. Dis., 2016, 2 (8), pp 552–563
DOI: 10.1021/acsinfecdis.6b00051
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Fluorescent Trimethoprim Conjugate Probes To Assess Drug Accumulation in Wild Type and Mutant Escherichia coli
ACS Infect. Dis., 2016, 2 (10), pp 688–701
DOI: 10.1021/acsinfecdis.6b00080
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Optimized Fluorescence Complementation Platform for Visualizing Salmonella Effector Proteins Reveals Distinctly Different Intracellular Niches in Different Cell Types
ACS Infect. Dis., 2017, 3 (8), pp 575–584
DOI: 10.1021/acsinfecdis.7b00052
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Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-13C]Pyruvate
ACS Infect. Dis., 2018, 4 (5), pp 797–805
DOI: 10.1021/acsinfecdis.7b00234
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[11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism
ACS Infect. Dis., 2018, 4 (7), pp 1067–1072
DOI: 10.1021/acsinfecdis.8b00061

ACS Medicinal Chemistry Letters
18F-Labeled Pyrido[3,4-d]pyrimidine as an Effective Probe for Imaging of L858R Mutant Epidermal Growth Factor Receptor
ACS Med. Chem. Lett., 2017, 8 (4), pp 418–422
DOI: 10.1021/acsmedchemlett.6b00520
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Prototypic 18F-Labeled Argininamide-Type Neuropeptide Y Y1R Antagonists as Tracers for PET Imaging of Mammary Carcinoma
ACS Med. Chem. Lett., 2017, 8 (3), pp 304–309
DOI: 10.1021/acsmedchemlett.6b00467
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Radiosynthesis of Carbon-11 Labeled Puromycin as a Potential PET Candidate for Imaging Protein Synthesis in Vivo
ACS Med. Chem. Lett., 2016, 7 (6), pp 647–651
DOI: 10.1021/acsmedchemlett.6b00093
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Astemizole Derivatives as Fluorescent Probes for hERG Potassium Channel Imaging
ACS Med. Chem. Lett., 2016, 7 (3), pp 245–249
DOI: 10.1021/acsmedchemlett.5b00360

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A New Highly Reactive and Low Lipophilicity Fluorine-18 Labeled Tetrazine Derivative for Pretargeted PET Imaging
ACS Med. Chem. Lett., 2016, 7 (1), pp 62–66
DOI: 10.1021/acsmedchemlett.5b00330


ACS Nano
Challenges and Opportunities for Intravital Near-Infrared Fluorescence Imaging Technology in the Second Transparency Window
ACS Nano, 2018, 12 (10), pp 9654–9659
DOI: 10.1021/acsnano.8b07536
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Correlated Materials Characterization via Multimodal Chemical and Functional Imaging
ACS Nano, 2018, 12 (12), pp 11798–11818
DOI: 10.1021/acsnano.8b07292
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Mitochondria-Targeted DNA Nanoprobe for Real-Time Imaging and Simultaneous Quantification of Ca2+ and pH in Neurons
ACS Nano, 2018, 12 (12), pp 12357–12368
DOI: 10.1021/acsnano.8b06322
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Large Hollow Cavity Luminous Nanoparticles with Near-Infrared Persistent Luminescence and Tunable Sizes for Tumor Afterglow Imaging and Chemo-/Photodynamic Therapies
ACS Nano, 2018, 12 (5), pp 4246–4258
DOI: 10.1021/acsnano.7b07606
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Cancer Cell Membrane-Biomimetic Nanoprobes with Two-Photon Excitation and Near-Infrared Emission for Intravital Tumor Fluorescence Imaging
ACS Nano, 2018, 12 (2), pp 1350–1358
DOI: 10.1021/acsnano.7b07716

Biochemistry
Chemistry Is Dead. Long Live Chemistry!
Biochemistry, 2017, 56 (39), pp 5165–5170
DOI: 10.1021/acs.biochem.7b00529
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Voltage Imaging: Pitfalls and Potential
Biochemistry, 2017, 56 (39), pp 5171–5177
DOI: 10.1021/acs.biochem.7b00490
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Bioluminescent Probes for Imaging Biology beyond the Culture Dish
Biochemistry, 2017, 56 (39), pp 5178–5184
DOI: 10.1021/acs.biochem.7b00435
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HIDE Probes: A New Toolkit for Visualizing Organelle Dynamics, Longer and at Super-Resolution
Biochemistry, 2017, 56 (39), pp 5194–5201
DOI: 10.1021/acs.biochem.7b00545
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Illuminating the Cell’s Biochemical Activity Architecture
Biochemistry, 2017, 56 (39), pp 5210–5213
DOI: 10.1021/acs.biochem.7b00561

Bioconjugate Chemistry
Combinatorial Screening of DNA Aptamers for Molecular Imaging of HER2 in Cancer
Bioconjugate Chem., 2017, 28 (4), pp 1068–1075
DOI: 10.1021/acs.bioconjchem.6b00746
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Preassembled Fluorescent Multivalent Probes for the Imaging of Anionic Membranes
Bioconjugate Chem., 2017, 28 (4), pp 1093–1101
DOI: 10.1021/acs.bioconjchem.7b00012
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Enhancing PET Signal at Target Tissue in Vivo: Dendritic and Multimeric Tris(hydroxypyridinone) Conjugates for Molecular Imaging of αvβ3 Integrin Expression with Gallium-68
Bioconjugate Chem., 2017, 28 (2), pp 481–495
DOI: 10.1021/acs.bioconjchem.6b00621
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Chelator-Free and Biocompatible Melanin Nanoplatform with Facile-Loading Gadolinium and Copper-64 for Bioimaging
Bioconjugate Chem., 2017, 28 (7), pp 1925–1930
DOI: 10.1021/acs.bioconjchem.7b00245
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Evaluation of a Centyrin-Based Near-Infrared Probe for Fluorescence-Guided Surgery of Epidermal Growth Factor Receptor Positive Tumors
Bioconjugate Chem., 2017, 28 (11), pp 2865–2873
DOI: 10.1021/acs.bioconjchem.7b00566

Journal of Medicinal Chemistry
Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain+
J. Med. Chem., 2018, 61 (8), pp 3296–3308
DOI: 10.1021/acs.jmedchem.7b01769
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A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation
J. Med. Chem., 2017, 60 (12), pp 5222–5227
DOI: 10.1021/acs.jmedchem.7b00432
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Lanthanides: Applications in Cancer Diagnosis and Therapy
J. Med. Chem., 2016, 59 (13), pp 6012–6024
DOI: 10.1021/acs.jmedchem.5b01975
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Discovery of 6-(Fluoro-18F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([18F]-MK-6240): A Positron Emission Tomography (PET) Imaging Agent for Quantification of Neurofibrillary Tangles (NFTs)
J. Med. Chem., 2016, 59 (10), pp 4778–4789
DOI: 10.1021/acs.jmedchem.6b00166
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Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives
J. Med. Chem., 2016, 59 (4), pp 1357–1369
DOI: 10.1021/acs.jmedchem.5b01537

Journal of Proteome Research
Mass Spectrometry Imaging, Laser Capture Microdissection, and LC-MS/MS of the Same Tissue Section
J. Proteome Res., 2017, 16 (8), pp 2993–3001
DOI: 10.1021/acs.jproteome.7b00284
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Glucose Restriction Combined with Autophagy Inhibition and Chemotherapy in HCT 116 Spheroids Decreases Cell Clonogenicity and Viability Regulated by Tumor Suppressor Genes
J. Proteome Res., 2017, 16 (8), pp 3009–3018
DOI: 10.1021/acs.jproteome.7b00293
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A Comparison of Common Mass Spectrometry Approaches for Paleoproteomics
J. Proteome Res., 2018, 17 (3), pp 936–945
DOI: 10.1021/acs.jproteome.7b00703
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Interactive Visual Exploration of 3D Mass Spectrometry Imaging Data Using Hierarchical Stochastic Neighbor Embedding Reveals Spatiomolecular Structures at Full Data Resolution
J. Proteome Res., 2018, 17 (3), pp 1054–1064
DOI: 10.1021/acs.jproteome.7b00725
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Dynamic Changes in the Protein Localization in the Nuclear Environment in Pancreatic β-Cell after Brief Glucose Stimulation
J. Proteome Res., 2018, 17 (4), pp 1664–1676
DOI: 10.1021/acs.jproteome.7b00930

Molecular Pharmaceutics
Effect of Dye and Conjugation Chemistry on the Biodistribution Profile of Near-Infrared-Labeled Nanobodies as Tracers for Image-Guided Surgery
Mol. Pharmaceutics, 2017, 14 (4), pp 1145–1153
DOI: 10.1021/acs.molpharmaceut.6b01053
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Viewing Molecular and Interface Interactions of Curcumin Amorphous Solid Dispersions for Comprehending Dissolution Mechanisms
Mol. Pharmaceutics, 2017, 14 (8), pp 2781–2792
DOI: 10.1021/acs.molpharmaceut.7b00319
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Tracking Antibody Distribution with Near-Infrared Fluorescent Dyes: Impact of Dye Structure and Degree of Labeling on Plasma Clearance
Mol. Pharmaceutics, 2017, 14 (5), pp 1623–1633
DOI: 10.1021/acs.molpharmaceut.6b01091
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18F-Alanine Derivative Serves as an ASCT2 Marker for Cancer Imaging
Mol. Pharmaceutics, 2018, 15 (3), pp 947–954
DOI: 10.1021/acs.molpharmaceut.7b00884
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ImmunoPET Imaging of CTLA-4 Expression in Mouse Models of Non-small Cell Lung Cancer
Mol. Pharmaceutics, 2017, 14 (5), pp 1782–1789
DOI: 10.1021/acs.molpharmaceut.7b00056

 

Urine Metabolite Could Signal Tuberculosis Treatment Success

A newly characterized metabolite in urine could one day help predict whether tuberculosis treatment is working or not. Concentration of the glycopeptide, which researchers believe is a metabolite of a protein called plasma protease C1 inhibitor — increase significantly in the urine of people with active pulmonary tuberculosis. In people who respond to treatment, metabolite levels dip back toward normal within a week. Though this initial study is small, such a test could help identify whether a candidate TB drug is likely to succeed or fail.

About a third of the world’s population — 1.8 billion people — is infected with Mycobacterium tuberculosis, the disease-causing bacterium, and new drugs to treat the disease are needed desperately. Current therapies fail in almost 1 out of 5 people, and treatment-resistant strains are becoming more prevalent. New drug trials are costly and challenging to run: researchers must treat patients for six months, and then follow up a year later to make sure the treatment worked, and the disease did not return.

“If you can identify patients early that have a higher likelihood to be cured by the treatment, then you may be able to reduce some complexity and the cost of the clinical trials,” says John Belisle, a microbiologist at Colorado State University. “The holy grail is if you can predict who’s going to relapse after the end of treatment.” That would provide a quick way to evaluate a drug’s efficacy early in the trial.

Several teams are looking for biomarkers that are affected by the disease. Belisle and his team decided to mine metabolites in urine — an easily-accessible biological fluid. In past work they identified several promising compounds whose levels changed during successful tuberculosis treatment. However, that study did not examine TB-infected people whose treatment failed.

Here, Belisle’s team used liquid chromatography with tandem mass spectrometry and enzymatic degradation to determine the structure of one of those metabolites, identifying it as a seryl-leucine core 1 O-glycosylated (SLC1G) peptide. They then measured it in the urine of 14 healthy individuals, 15 people with tuberculosis who were successfully treated with standard anti-TB treatment, 8 who failed treatment, and 12 in whom the treatment initially worked but the disease later recurred, at multiple points during the 6-month drug regimen.

In people whose treatment was successful, SLC1G levels fell approximately four-fold during the course of treatment, but did not drop significantly in people for whom the treatment ultimately didn’t work. Whether or not the therapy ultimately worked, higher SLC1G levels were associated with more lung inflammation and a higher bacterial load.

A biomarker like SLC1G “might allow faster evaluation of new drug regimens, for example, by showing early on whether patients are responding differentially to different novel regimens,” says Anna Upton, senior director of biology at TB Alliance, a nonprofit dedicated to developing better tuberculosis drugs. While the work is promising, she cautions, the small number of people in the study means that “further, larger studies are needed to see whether the associations seen here for SLC1G bear out in larger patient populations.”

The researchers are continuing their work with an expanded sample pool — and particularly with more people whose treatment ultimately failed. They are also developing a mass spectrometry assay that can more accurately quantify the peptide. If it holds up in further testing, Belisle believes SLC1G can be used as part of a molecular signature predicting treatment success.

This article is reproduced with permission from C&EN (© American Chemical Society). The article was first published on January 30, 2019.

Discover the Most-Read Physical Chemistry Articles of February 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in February 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Get free monthly updates on the most-read research in your field.

Read more of February’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical

ACS Applied Energy Materials

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Nascent SEI-Surface Films on Single Crystalline Silicon Investigated by Scanning Electrochemical Microscopy
ACS Appl. Energy Mater., 2019, 2 (2), pp 1388–1392
DOI: 10.1021/acsaem.8b01967

Overcoming the High-Voltage Limitations of Li-Ion Batteries Using a Titanium Nitride Current Collector
Open Access Through ACS AuthorChoice
ACS Appl. Energy Mater., 2019, 2 (2), pp 974–978
DOI: 10.1021/acsaem.8b01771

Strain Effects on Oxygen Reduction Activity of Pr2NiO4 Caused by Gold Bulk Dispersion for Low Temperature Solid Oxide Fuel Cells
ACS Appl. Energy Mater., 2019, 2 (2), pp 1210–1220
DOI: 10.1021/acsaem.8b01776

Flame Aerosol Synthesis and Electrochemical Characterization of Ni-Rich Layered Cathode Materials for Li-Ion Batteries
Open Access Through ACS AuthorChoice
ACS Appl. Energy Mater., 2019, 2 (2), pp 1319–1329
DOI: 10.1021/acsaem.8b01892

Fiber-Shaped Electrochemical Capacitors Based on Plasma-Engraved Graphene Fibers with Oxygen Vacancies for Alternating Current Line Filtering Performance
ACS Appl. Energy Mater., 2019, 2 (2), pp 993–999
DOI: 10.1021/acsaem.8b02060


ACS Earth and Space Chemistry

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Unique Environmental Conditions Required for Dawsonite Formation: Implications from Dawsonite Synthesis Experiments under Alkaline Conditions
Open Access Through ACS AuthorChoice
ACS Earth Space Chem., 2019, 3 (2), pp 285–294
DOI: 10.1021/acsearthspacechem.8b00121

Formation of Methane and (Per)Chlorates on Mars
ACS Earth Space Chem., 2019, 3 (2), pp 221–232
DOI: 10.1021/acsearthspacechem.8b00104

Reactive Uptake of Glyoxal by Methylaminium-Containing Salts as a Function of Relative Humidity
ACS Earth Space Chem., 2019, 3 (2), pp 150–157
DOI: 10.1021/acsearthspacechem.8b00154

Vertical Characterization and Source Apportionment of Water-Soluble Organic Aerosol with High-resolution Aerosol Mass Spectrometry in Beijing, China
ACS Earth Space Chem., 2019, 3 (2), pp 273–284
DOI: 10.1021/acsearthspacechem.8b00155

Atmospheric β-Caryophyllene-Derived Ozonolysis Products at Interfaces
ACS Earth Space Chem., 2019, 3 (2), pp 158–169
DOI: 10.1021/acsearthspacechem.8b00156


ACS Energy Letters

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Citation Mania: The Good, the Bad, and the Ugly
ACS Energy Lett., 2019, 4 (2), pp 471–472
DOI: 10.1021/acsenergylett.9b00016

Status and Outlook for Magnesium Battery Technologies: A Conversation with Stan Whittingham and Sarbajit Banerjee
ACS Energy Lett., 2019, 4 (2), pp 572–575
DOI: 10.1021/acsenergylett.9b00214

Quaternary Layered Ni-Rich NCMA Cathode for Lithium-Ion Batteries
ACS Energy Lett., 2019, 4 (2), pp 576–582
DOI: 10.1021/acsenergylett.8b02499

Photochemical Conversion and Storage of Solar Energy
ACS Energy Lett., 2019, 4 (2), pp 405–410
DOI: 10.1021/acsenergylett.8b02411

Interphase Morphology between a Solid-State Electrolyte and Lithium Controls Cell Failure
ACS Energy Lett., 2019, 4 (2), pp 591–599
DOI: 10.1021/acsenergylett.9b00093


ACS Photonics

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Quantifying Figures of Merit for Localized Surface Plasmon Resonance Applications: A Materials Survey
ACS Photonics, 2019, 6 (2), pp 240–259
DOI: 10.1021/acsphotonics.8b01369

Limits to Strong Coupling of Excitons in Multilayer WS2 with Collective Plasmonic Resonances
ACS Photonics, 2019, 6 (2), pp 286–293
DOI: 10.1021/acsphotonics.8b01459

Radiation of Dynamic Toroidal Moments
Open Access Through ACS AuthorChoice
ACS Photonics, 2019, 6 (2), pp 467–474
DOI: 10.1021/acsphotonics.8b01422

In Situ Fabrication of 2D WS2/Si Type-II Heterojunction for Self-Powered Broadband Photodetector with Response up to Mid-Infrared
Open Access Through ACS Editors’ Choice
ACS Photonics, 2019, 6 (2), pp 565–572
DOI: 10.1021/acsphotonics.8b01675

Strained Bubbles in van der Waals Heterostructures as Local Emitters of Photoluminescence with Adjustable Wavelength
ACS Photonics, 2019, 6 (2), pp 516–524
DOI: 10.1021/acsphotonics.8b01497


Energy & Fuels

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Electrochemically Assisted Deposition of Calcite for Application in Surfactant Adsorption Studies
Energy Fuels, 2019, 33 (2), pp 805–813
DOI: 10.1021/acs.energyfuels.8b03572

Liquefaction of Lignosulfonate in Supercritical Ethanol Using Alumina-Supported NiMo Catalyst
Open Access Through ACS Editors’ Choice
Energy Fuels, 2019, 33 (2), pp 1196–1209
DOI: 10.1021/acs.energyfuels.8b03519

Nanopyroxene-Based Nanofluids for Enhanced Oil Recovery in Sandstone Cores at Reservoir Temperature
Energy Fuels, 2019, 33 (2), pp 877–890
DOI: 10.1021/acs.energyfuels.8b03749

Optimal Applications and Combinations of Renewable Fuel Production from Biomass and Electricity
Energy Fuels, 2019, 33 (2), pp 1659–1672
DOI: 10.1021/acs.energyfuels.8b03790

Investigation into the Effect of Heteroatom Content on Kerogen Structure Using Advanced 13C Solid-State Nuclear Magnetic Resonance Spectroscopy
Energy Fuels, 2019, 33 (2), pp 645–653
DOI: 10.1021/acs.energyfuels.8b01909


Industrial & Engineering Chemistry Research

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High Pressure Electrochemical Reduction of CO2 to Formic Acid/Formate: A Comparison between Bipolar Membranes and Cation Exchange Membranes
Open Access Through ACS AuthorChoice
Ind. Eng. Chem. Res., 2019, 58 (5), pp 1834–1847
DOI: 10.1021/acs.iecr.8b04944

Kinetic Study of Homogeneous Catalyzed Esterification of a Series of Aliphatic Acids with Different Alcohols
Ind. Eng. Chem. Res., 2019, 58 (8), pp 2672–2682
DOI: 10.1021/acs.iecr.8b04781

Esterification of Methacrylic Acid with Methanol: Process Optimization, Kinetic Modeling, and Reactive Distillation
Ind. Eng. Chem. Res., 2019, 58 (6), pp 2135–2145
DOI: 10.1021/acs.iecr.8b03842

Mesoporous Manganese Dioxide Coated Gold Nanorods as a Multiresponsive Nanoplatform for Drug Delivery
Ind. Eng. Chem. Res., 2019, 58 (8), pp 2991–2999
DOI: 10.1021/acs.iecr.8b05331

Process Design Alternatives for Producing Ultra-high-purity Electronic-Grade Propylene Glycol Monomethyl Ether Acetate
Ind. Eng. Chem. Res., 2019, 58 (6), pp 2246–2257
DOI: 10.1021/acs.iecr.8b04052


Journal of Chemical & Engineering Data

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Editorial: Guidelines for the Measurement of Solid–Liquid Solubility Data at Atmospheric Pressure
J. Chem. Eng. Data, 2019, 64 (2), pp 381–385
DOI: 10.1021/acs.jced.8b01263

Viscosities of Liquid Hexadecane at Temperatures between 323 K and 673 K and Pressures up to 4 MPa Measured Using a Dual-Capillary Viscometer
J. Chem. Eng. Data, 2019, 64 (2), pp 706–712
DOI: 10.1021/acs.jced.8b00930

Molecular Dynamics Study of Adsorption of the Lennard-Jones Truncated and Shifted Fluid on Planar Walls
Published as part of The Journal of Chemical and Engineering Data special issue “Proceedings of the 20th Symposium on Thermophysical Properties”
J. Chem. Eng. Data, 2019, 64 (2), pp 386–394
DOI: 10.1021/acs.jced.8b00927

Viscosity and Density of Binary Mixtures of Ethanol + Igepal (CO-520, CO-630, CO-720, and CA-720)
J. Chem. Eng. Data, 2019, 64 (2), pp 594–602
DOI: 10.1021/acs.jced.8b00793

Thermodynamic Study of Four {Methylpiperidine + Water} Systems: New Experimental Data and Challenging Modeling for the Simultaneous Representation of Liquid–Liquid Equilibrium and Energetic Properties
J. Chem. Eng. Data, 2019, 64 (2), pp 743–754
DOI: 10.1021/acs.jced.8b00974


Journal of Chemical Information and Modeling

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Thermodynamic Study of Four {Methylpiperidine + Water} Systems: New Experimental Data and Challenging Modeling for the Simultaneous Representation of Liquid–Liquid Equilibrium and Energetic Properties
J. Chem. Eng. Data, 2019, 64 (2), pp 743–754
DOI: 10.1021/acs.jced.8b00974

Assessing the Predictive Power of Relative Binding Free Energy Calculations for Test Cases Involving Displacement of Binding Site Water Molecules
Open Access Through ACS AuthorChoice
J. Chem. Inf. Model., 2019, 59 (2), pp 754–765
DOI: 10.1021/acs.jcim.8b00826

Virtual Compound Libraries in Computer-Assisted Drug Discovery
J. Chem. Inf. Model., 2019, 59 (2), pp 644–651
DOI: 10.1021/acs.jcim.8b00737

Correction to “Efficiency of Stratification for Ensemble Docking Using Reduced Ensembles”
J. Chem. Inf. Model., 2019, 59 (2), pp 944–944
DOI: 10.1021/acs.jcim.9b00077

Enhancing Retrosynthetic Reaction Prediction with Deep Learning Using Multiscale Reaction Classification
J. Chem. Inf. Model., 2019, 59 (2), pp 673–688
DOI: 10.1021/acs.jcim.8b00801


Journal of Chemical Theory and Computation

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OpenPathSampling: A Python Framework for Path Sampling Simulations. 1. Basics
Open Access Through ACS AuthorChoice
J. Chem. Theory Comput., 2019, 15 (2), pp 813–836
DOI: 10.1021/acs.jctc.8b00626

Open-Source, Python-Based Redevelopment of the ChemShell Multiscale QM/MM Environment
Open Access Through ACS AuthorChoice
J. Chem. Theory Comput., 2019, 15 (2), pp 1317–1328
DOI: 10.1021/acs.jctc.8b01036

OpenPathSampling: A Python Framework for Path Sampling Simulations. 2. Building and Customizing Path Ensembles and Sample Schemes
Open Access Through ACS AuthorChoice
J. Chem. Theory Comput., 2019, 15 (2), pp 837–856
DOI: 10.1021/acs.jctc.8b00627

Multiconfigurational Self-Consistent Field Theory with Density Matrix Embedding: The Localized Active Space Self-Consistent Field Method
J. Chem. Theory Comput., 2019, 15 (2), pp 972–986
DOI: 10.1021/acs.jctc.8b01009

Fast and Accurate Uncertainty Estimation in Chemical Machine Learning
J. Chem. Theory Comput., 2019, 15 (2), pp 906–915
DOI: 10.1021/acs.jctc.8b00959


The Journal of Physical Chemistry A

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Role of pH in Aerosol Processes and Measurement Challenges
Open Access Through ACS Editors’ Choice
J. Phys. Chem. A, 2019, 123 (7), pp 1275–1284
DOI: 10.1021/acs.jpca.8b10676

Ultra-Fast-VUV Photoemission Study of UV Excited 2-Nitrophenol
J. Phys. Chem. A, 2019, 123 (7), pp 1295–1302
DOI: 10.1021/acs.jpca.8b10136

Theoretical Study of the Charge Transfer Exciton Binding Energy in Semiconductor Materials for Polymer:Fullerene-Based Bulk Heterojunction Solar Cells
Open Access Through ACS AuthorChoice
J. Phys. Chem. A, 2019, 123 (6), pp 1233–1242
DOI: 10.1021/acs.jpca.8b12292

Inter/Intramolecular Bonds in TH5+ (T = C/Si/Ge): H2 as Tetrel Bond Acceptor and the Uniqueness of Carbon Bonds
J. Phys. Chem. A, 2019, 123 (6), pp 1168–1176
DOI: 10.1021/acs.jpca.8b09778

Potential Energy Surface of Group 11 Trimers (Cu, Ag, Au): Bond Angle Isomerism in Au3
J. Phys. Chem. A, 2019, 123 (6), pp 1198–1207
DOI: 10.1021/acs.jpca.8b11219


The Journal of Physical Chemistry B

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Internal Coordinate Normal Mode Analysis: A Strategy To Predict Protein Conformational Transitions
J. Phys. Chem. B, 2019, 123 (6), pp 1294–1301
DOI: 10.1021/acs.jpcb.8b11913

Integrated NMR, Fluorescence, and Molecular Dynamics Benchmark Study of Protein Mechanics and Hydrodynamics
Open Access Through ACS AuthorChoice
J. Phys. Chem. B, 2019, 123 (7), pp 1453–1480
DOI: 10.1021/acs.jpcb.8b08903

Unfolding Dynamics of Ubiquitin from Constant Force MD Simulation: Entropy–Enthalpy Interplay Shapes the Free-Energy Landscape
J. Phys. Chem. B, 2019, 123 (6), pp 1228–1236
DOI: 10.1021/acs.jpcb.8b09318

Resolving the Morphology of Peptoid Vesicles at the 1 nm Length Scale Using Cryogenic Electron Microscopy
Open Access Through ACS Editors’ Choice
J. Phys. Chem. B, 2019, 123 (5), pp 1195–1205
DOI: 10.1021/acs.jpcb.8b11752

Toward Ab Initio Protein Folding: Inherent Secondary Structure Propensity of Short Peptides from the Bioinformatics and Quantum-Chemical Perspective
J. Phys. Chem. B, 2019, 123 (6), pp 1215–1227
DOI: 10.1021/acs.jpcb.8b09245


The Journal of Physical Chemistry C

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Tunneling Diffusion of Excess Protons in Amorphous Solid Water at 10 and 80 K
J. Phys. Chem. C, 2019, 123 (6), pp 3657–3663
DOI: 10.1021/acs.jpcc.8b11829

Emerging Design Principles for Enhanced Solar Energy Utilization with Singlet Fission
J. Phys. Chem. C, 2019, 123 (7), pp 3923–3934
DOI: 10.1021/acs.jpcc.8b10876

Cu-Based Single-Atom Catalysts Boost Electroreduction of CO2 to CH3OH: First-Principles Predictions
J. Phys. Chem. C, 2019, 123 (7), pp 4380–4387
DOI: 10.1021/acs.jpcc.8b12449

Photoexcited Dynamics in Metal Halide Perovskites: From Relaxation Mechanisms to Applications
J. Phys. Chem. C, 2019, 123 (6), pp 3255–3269
DOI: 10.1021/acs.jpcc.8b11347

Electrodes as Polarizing Functional Groups: Correlation between Hammett Parameters and Electrochemical Polarization
J. Phys. Chem. C, 2019, 123 (8), pp 4926–4937
DOI: 10.1021/acs.jpcc.8b12058


The Journal of Physical Chemistry Letters

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Photocatalytic and Photoelectrochemical Degradation of Organic Compounds with All-Inorganic Metal Halide Perovskite Quantum Dots
Open Access Through ACS Editors’ Choice
J. Phys. Chem. Lett., 2019, 10 (3), pp 630–636
DOI: 10.1021/acs.jpclett.8b03849

Chinese Spring Festival Editorial
J. Phys. Chem. Lett., 2019, 10 (3), pp 701–701
DOI: 10.1021/acs.jpclett.9b00263

Highly Efficient Ultralong Organic Phosphorescence through Intramolecular-Space Heavy-Atom Effect
J. Phys. Chem. Lett., 2019, 10 (3), pp 595–600
DOI: 10.1021/acs.jpclett.8b03712

Nonsymmetrical Connection of Two Identical Building Blocks: Constructing Donor–Acceptor Molecules as Deep Blue Emitting Materials for Efficient Organic Emitting Diodes
J. Phys. Chem. Lett., 2019, 10 (4), pp 842–847
DOI: 10.1021/acs.jpclett.9b00300

Less Is More: Dilution Enhances Optical and Electrical Performance of a TADF Exciplex
J. Phys. Chem. Lett., 2019, 10 (4), pp 793–798
DOI: 10.1021/acs.jpclett.8b03646

Discover the Most-Read Organic/Inorganic Chemistry Articles of February 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in February 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Get free monthly updates on the most-read research in your field.

Read more of February’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical


ACS Catalysis

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Synthesis of α-Fluoro-α-amino Acid Derivatives via Photoredox-Catalyzed Carbofluorination
ACS Catal., 2019, 9 (2), pp 1558–1563
DOI: 10.1021/acscatal.8b04284

Effective Use of Renewable Electricity for Making Renewable Fuels and Chemicals
ACS Catal., 2019, 9 (2), pp 946–950
DOI: 10.1021/acscatal.8b04143

What Is Measured When Measuring Acidity in Zeolites with Probe Molecules?
Open Access Through ACS AuthorChoice
ACS Catal., 2019, 9 (2), pp 1539–1548
DOI: 10.1021/acscatal.8b04317

Carbonyl–Olefin Metathesis Catalyzed by Molecular Iodine
ACS Catal., 2019, 9 (2), pp 912–919
DOI: 10.1021/acscatal.8b03769

Visible-Light-Mediated Regioselective Chlorosulfonylation of Alkenes and Alkynes: Introducing the Cu(II) Complex [Cu(dap)Cl2] to Photochemical ATRA Reactions
ACS Catal., 2019, 9 (2), pp 1103–1109
DOI: 10.1021/acscatal.8b04188


ACS Combinatorial Science

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Quantitative Comparison of Enrichment from DNA-Encoded Chemical Library Selections
ACS Comb. Sci., 2019, 21 (2), pp 75–82
DOI: 10.1021/acscombsci.8b00116

Mild and Efficient Palladium-Mediated C–N Cross-Coupling Reaction between DNA-Conjugated Aryl Bromides and Aromatic Amines
ACS Comb. Sci., 2019, 21 (2), pp 69–74
DOI: 10.1021/acscombsci.8b00142

Advances in the Solid-Phase Synthesis of Pyrimidine Derivatives
ACS Comb. Sci., 2019, 21 (2), pp 35–68
DOI: 10.1021/acscombsci.8b00172

Exploration of Catalytic Nucleic Acids on Porphyrin Metalation and Peroxidase Activity by in Vitro Selection of Aptamers for N-Methyl Mesoporphyrin IX
ACS Comb. Sci., 2019, 21 (2), pp 83–89
DOI: 10.1021/acscombsci.8b00129

FTIR Spectroscopy Suggests a Revised Mode of Action for the Cationic Side-Chain Effect of Ionic Liquids
ACS Comb. Sci., 2019, 21 (2), pp 90–97
DOI: 10.1021/acscombsci.8b00141


ACS Medicinal Chemistry Letters

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Tissue Imaging by Mass Spectrometry: A Practical Guide for the Medicinal Chemist
ACS Med. Chem. Lett., 2019, 10 (2), pp 161–167
DOI: 10.1021/acsmedchemlett.8b00480

Evolution of Small Molecule Kinase Drugs
ACS Med. Chem. Lett., 2019, 10 (2), pp 153–160
DOI: 10.1021/acsmedchemlett.8b00445

Cytosine-Based TET Enzyme Inhibitors
ACS Med. Chem. Lett., 2019, 10 (2), pp 180–185
DOI: 10.1021/acsmedchemlett.8b00474

TRPV1 Modulators for the Treatment of Pain and Inflammation
ACS Med. Chem. Lett., 2019, 10 (2), pp 143–144
DOI: 10.1021/acsmedchemlett.8b00618

Imidazoquinolines as Novel Inhibitors of LRRK2 Kinase Activity
ACS Med. Chem. Lett., 2019, 10 (2), pp 148–149
DOI: 10.1021/acsmedchemlett.8b00654


Bioconjugate Chemistry

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Delivery of Proteins and Nucleic Acids: Achievements and Challenges
This article is part of the Delivery of Proteins and Nucleic Acids: Achievements and Challenges special issue.
Bioconjugate Chem., 2019, 30 (2), pp 261–262
DOI: 10.1021/acs.bioconjchem.9b00096

Overcoming Endosomal Entrapment in Drug Delivery
This article is part of the Delivery of Proteins and Nucleic Acids: Achievements and Challenges special issue.
Bioconjugate Chem., 2019, 30 (2), pp 273–283
DOI: 10.1021/acs.bioconjchem.8b00778

The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery
This article is part of the Delivery of Proteins and Nucleic Acids: Achievements and Challenges special issue.
Bioconjugate Chem., 2019, 30 (2), pp 263–272
DOI: 10.1021/acs.bioconjchem.8b00732

Bioconjugated Oligonucleotides: Recent Developments and Therapeutic Applications
This article is part of the Delivery of Proteins and Nucleic Acids: Achievements and Challenges special issue.
Bioconjugate Chem., 2019, 30 (2), pp 366–383
DOI: 10.1021/acs.bioconjchem.8b00761

Recent Advances in Anti-cancer Protein/Peptide Delivery
Bioconjugate Chem., 2019, 30 (2), pp 305–324
DOI: 10.1021/acs.bioconjchem.8b00750


Inorganic Chemistry

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Actinide Chemistry at the Extreme
Inorg. Chem., 2019, 58 (3), pp 1721–1723
DOI: 10.1021/acs.inorgchem.8b03603

Effects of Lewis Acidic Metal Ions (M) on Oxygen-Atom Transfer Reactivity of Heterometallic Mn3MO4 Cubane and Fe3MO(OH) and Mn3MO(OH) Clusters
Inorg. Chem., 2019, 58 (4), pp 2336–2345
DOI: 10.1021/acs.inorgchem.8b02701

Histidine Targeting Heterobimetallic Ruthenium(II)–Gold(I) Complexes
Open Access Through ACS AuthorChoice
Inorg. Chem., 2019, 58 (4), pp 2501–2513
DOI: 10.1021/acs.inorgchem.8b03069

Luminescent Ruthenium(II) Polypyridine Complexes for a Wide Variety of Biomolecular and Cellular Applications
Inorg. Chem., 2019, 58 (4), pp 2231–2247
DOI: 10.1021/acs.inorgchem.8b02979

Superhydrophobic/Superoleophilic MOF Composites for Oil–Water Separation
Inorg. Chem., 2019, 58 (4), pp 2261–2264
DOI: 10.1021/acs.inorgchem.8b03293


Journal of Medicinal Chemistry

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Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors
Open Access Through ACS Editors’ Choice
J. Med. Chem., 2019, 62 (4), pp 1781–1792
DOI: 10.1021/acs.jmedchem.8b01725

Retraction of “CNS Physicochemical Property Space Shaped by a Diverse Set of Molecules with Experimentally Determined Exposure in the Mouse Brain”
J. Med. Chem., 2019, 62 (3), pp 1699–1699
DOI: 10.1021/acs.jmedchem.8b01388

Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits
J. Med. Chem., 2019, 62 (3), pp 1626–1642
DOI: 10.1021/acs.jmedchem.8b01884

Cubanes in Medicinal Chemistry
J. Med. Chem., 2019, 62 (3), pp 1078–1095
DOI: 10.1021/acs.jmedchem.8b00888

6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors
Open Access Through ACS Editors’ Choice
J. Med. Chem., 2019, 62 (4), pp 1793–1802
DOI: 10.1021/acs.jmedchem.8b01726


Journal of Natural Products

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Bioactive Diterpenoids from the Stems of Euphorbia royleana
J. Nat. Prod., 2019, 82 (2), pp 183–193
DOI: 10.1021/acs.jnatprod.8b00493

LC-HRMS-Database Screening Metrics for Rapid Prioritization of Samples to Accelerate the Discovery of Structurally New Natural Products
J. Nat. Prod., 2019, 82 (2), pp 211–220
DOI: 10.1021/acs.jnatprod.8b00575

Acidiphilamides A–E, Modified Peptides as Autophagy Inhibitors from an Acidophilic Actinobacterium, Streptacidiphilus rugosus
J. Nat. Prod., 2019, 82 (2), pp 341–348
DOI: 10.1021/acs.jnatprod.8b00828

Synthesis and Structure Reassignment of Malylglutamate, a Recently Discovered Earthworm Metabolite
J. Nat. Prod., 2019, 82 (2), pp 417–421
DOI: 10.1021/acs.jnatprod.8b01083

Lignan Dimers from Forsythia viridissima Roots and Their Antiviral Effects
J. Nat. Prod., 2019, 82 (2), pp 232–238
DOI: 10.1021/acs.jnatprod.8b00590


The Journal of Organic Chemistry

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[6π] Photocyclization to cis-Hexahydrocarbazol-4-ones: Substrate Modification, Mechanism, and Scope
Open Access Through ACS AuthorChoice
J. Org. Chem., 2019, 84 (3), pp 1139–1153
DOI: 10.1021/acs.joc.8b03144

Catalytic One-Step Deoxytrifluoromethylation of Alcohols
J. Org. Chem., 2019, 84 (4), pp 2061–2071
DOI: 10.1021/acs.joc.8b03072

Preparation and Physicochemical Properties of [6]Helicenes Fluorinated at Terminal Rings
J. Org. Chem., 2019, 84 (4), pp 1980–1993
DOI: 10.1021/acs.joc.8b02870

Selective Oxidative Phenol Coupling by Iron Catalysis
J. Org. Chem., 2019, 84 (4), pp 1677–1686
DOI: 10.1021/acs.joc.8b03084

NMR Quantification of Hydrogen-Bond-Activating Effects for Organocatalysts including Boronic Acids
J. Org. Chem., 2019, 84 (3), pp 1126–1138
DOI: 10.1021/acs.joc.8b02389


Molecular Pharmaceutics

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Transferrin Receptor-Mediated Uptake at the Blood–Brain Barrier Is Not Impaired by Alzheimer’s Disease Neuropathology
Mol. Pharmaceutics, 2019, 16 (2), pp 583–594
DOI: 10.1021/acs.molpharmaceut.8b00870

Quantification of Proteins Involved in Drug Metabolism and Disposition in the Human Liver Using Label-Free Global Proteomics
Mol. Pharmaceutics, 2019, 16 (2), pp 632–647
DOI: 10.1021/acs.molpharmaceut.8b00941

Nanoparticle Properties for Delivery to Cartilage: The Implications of Disease State, Synovial Fluid, and Off-Target Uptake
Mol. Pharmaceutics, 2019, 16 (2), pp 469–479
DOI: 10.1021/acs.molpharmaceut.7b00484

Effect of Polymer Hydrophobicity on the Stability of Amorphous Solid Dispersions and Supersaturated Solutions of a Hydrophobic Pharmaceutical
Mol. Pharmaceutics, 2019, 16 (2), pp 682–688
DOI: 10.1021/acs.molpharmaceut.8b00972

Quantitative Imaging of the Hypoxia-Related Marker CAIX in Head and Neck Squamous Cell Carcinoma Xenograft Models
Open Access Through ACS AuthorChoice
Mol. Pharmaceutics, 2019, 16 (2), pp 701–708
DOI: 10.1021/acs.molpharmaceut.8b00950


Organic Letters

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Retraction of “Iron-Catalyzed Three-Component Reaction: Synthesis of Fluoroalkylated 2H-Azirines”
Org. Lett., 2019, 21 (3), pp 850–850
DOI: 10.1021/acs.orglett.8b03324

Catalyst-Free, Direct Electrochemical Tri- and Difluoroalkylation/Cyclization: Access to Functionalized Oxindoles and Quinolinones
Org. Lett., 2019, 21 (4), pp 1237–1240
DOI: 10.1021/acs.orglett.9b00361

Palladium-Catalyzed Oxidative Allylation of Sulfoxonium Ylides: Regioselective Synthesis of Conjugated Dienones
Org. Lett., 2019, 21 (4), pp 872–875
DOI: 10.1021/acs.orglett.8b03606

Enantioselective Total Synthesis of (−)-Δ9-Tetrahydrocannabinol via N-Heterocyclic Carbene Catalysis
Org. Lett., 2019, 21 (4), pp 1212–1215
DOI: 10.1021/acs.orglett.9b00198

Enantioselective Synthesis of Nicotine via an Iodine-Mediated Hofmann–Löffler Reaction
Open Access Through ACS Editors’ Choice
Org. Lett., 2019, 21 (3), pp 705–708
DOI: 10.1021/acs.orglett.8b03909


Organic Process Research & Development

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Gender Diversity in Process Chemistry
Org. Process Res. Dev., 2019, 23 (2), pp 109–113
DOI: 10.1021/acs.oprd.8b00378

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2019, 23 (2), pp 114–121
DOI: 10.1021/acs.oprd.9b00036

Development of a Large-Scale Asymmetric Process for tert-Butanesulfinamide
Open Access Through ACS Editors’ Choice
Org. Process Res. Dev., 2019, 23 (2), pp 263–268
DOI: 10.1021/acs.oprd.8b00399

Progress to Date in the Design and Operation of Continuous Crystallization Processes for Pharmaceutical Applications
Org. Process Res. Dev., 2019, 23 (2), pp 122–144
DOI: 10.1021/acs.oprd.8b00319

Automated On-Demand Titration of Organometallic Reagents in Continuous Flow
Org. Process Res. Dev., 2019, 23 (2), pp 278–282
DOI: 10.1021/acs.oprd.8b00434


Organometallics

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How To Make Your Computational Paper Interesting and Have It Published
Organometallics, 2019, 38 (3), pp 603–605
DOI: 10.1021/acs.organomet.8b00942

Neutral Mono(5-aryl-2-iminopyrrolyl)nickel(II) Complexes as Precatalysts for the Synthesis of Highly Branched Ethylene Oligomers: Preparation, Molecular Characterization, and Catalytic Studies
Open Access Through ACS Editors’ Choice
Organometallics, 2019, 38 (3), pp 614–625
DOI: 10.1021/acs.organomet.8b00669

Zinc-Mediated Chain Transfer from Hafnium to Aluminum in the Hafnium-Pyridyl Amido-Catalyzed Polymerization of 1-Octene Revealed by Job Plot Analysis
Open Access Through ACS Editors’ Choice
Organometallics, 2019, 38 (4), pp 926–932
DOI: 10.1021/acs.organomet.8b00900

Tandem Remote Csp3–H Activation/Csp3–Csp3 Cleavage in Unstrained Aliphatic Chains Assisted by Palladium(II)
Organometallics, 2019, 38 (4), pp 973–980
DOI: 10.1021/acs.organomet.8b00920

Two Carbenes versus One in Magnesium Chemistry: Synthesis of Terminal Dihalide, Dialkyl, and Grignard Reagents
Organometallics, 2019, 38 (3), pp 688–696
DOI: 10.1021/acs.organomet.8b00866

Discover the Most-Read Multidisciplinary Chemistry Articles of February 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in February 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Get free monthly updates on the most-read research in your field.

Read more of February’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical


Accounts of Chemical Research

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Metal–Organic Frameworks for Photocatalysis and Photothermal Catalysis
Acc. Chem. Res., 2019, 52 (2), pp 356–366
DOI: 10.1021/acs.accounts.8b00521

Materials, Structures, and Functions for Flexible and Stretchable Biomimetic Sensors
Published as part of the Accounts of Chemical Research special issue Wearable Bioelectronics: Chemistry, Materials, Devices, and Systems
Acc. Chem. Res., 2019, 52 (2), pp 288–296
DOI: 10.1021/acs.accounts.8b00497

Directed Evolution of Artificial Metalloenzymes: A Universal Means to Tune the Selectivity of Transition Metal Catalysts?
Published as part of the Accounts of Chemical Research special issue Artificial Metalloenzymes and Abiological Catalysis of Metalloenzymes
Acc. Chem. Res., 2019, 52 (2), pp 336–344
DOI: 10.1021/acs.accounts.8b00582

NHC-Catalyzed Generation of α,β-Unsaturated Acylazoliums for the Enantioselective Synthesis of Heterocycles and Carbocycles
Acc. Chem. Res., 2019, 52 (2), pp 425–436
DOI: 10.1021/acs.accounts.8b00550

Functionalized Organic Thin Film Transistors for Biosensing
Published as part of the Accounts of Chemical Research special issue “Wearable Bioelectronics: Chemistry, Materials, Devices, and Systems”.
Acc. Chem. Res., 2019, 52 (2), pp 277–287
DOI: 10.1021/acs.accounts.8b00448


ACS Central Science

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Turning Organic Waste into Hydrogen
Open Access Through ACS AuthorChoice
ACS Cent. Sci., 2019, 5 (2), pp 203–205
DOI: 10.1021/acscentsci.9b00132

A Biocatalytic Platform for Synthesis of Chiral α-Trifluoromethylated Organoborons
Open Access Through ACS AuthorChoice
ACS Cent. Sci., 2019, 5 (2), pp 270–276
DOI: 10.1021/acscentsci.8b00679

Frontiers in Probing Alzheimer’s Disease Biomarkers with Fluorescent Small Molecules
Open Access Through ACS AuthorChoice
ACS Cent. Sci., 2019, 5 (2), pp 209–217
DOI: 10.1021/acscentsci.8b00951

Colocalization of m6A and G-Quadruplex-Forming Sequences in Viral RNA (HIV, Zika, Hepatitis B, and SV40) Suggests Topological Control of Adenosine N6-Methylation
Open Access Through ACS AuthorChoice
ACS Cent. Sci., 2019, 5 (2), pp 218–228
DOI: 10.1021/acscentsci.8b00963

Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities
Open Access Through ACS AuthorChoice
ACS Cent. Sci., 2019, 5 (2), pp 237–249
DOI: 10.1021/acscentsci.8b00588


ACS Omega

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Synthetic Control of Protein Degradation during Cell Proliferation and Developmental Processes
Open Access Through ACS AuthorChoice
ACS Omega, 2019, 4 (2), pp 2766–2778
DOI: 10.1021/acsomega.8b03011

Discovery of High-Affinity Noncovalent Allosteric KRAS Inhibitors That Disrupt Effector Binding
Open Access Through ACS AuthorChoice
ACS Omega, 2019, 4 (2), pp 2921–2930
DOI: 10.1021/acsomega.8b03308

Workflows Allowing Creation of Journal Article Supporting Information and Findable, Accessible, Interoperable, and Reusable (FAIR)-Enabled Publication of Spectroscopic Data
Open Access Through ACS AuthorChoice
ACS Omega, 2019, 4 (2), pp 3280–3286
DOI: 10.1021/acsomega.8b03005

Evaluating Large-Scale STEM Outreach Efficacy with a Consistent Theme: Thermodynamics for Elementary School Students
Open Access Through ACS AuthorChoice
ACS Omega, 2019, 4 (2), pp 2661–2668
DOI: 10.1021/acsomega.8b03156

Amine-Modified Mesoporous Magnesium Carbonate as an Effective Adsorbent for Azo Dyes
Open Access Through ACS AuthorChoice
ACS Omega, 2019, 4 (2), pp 2973–2979
DOI: 10.1021/acsomega.8b03493


Chemical Reviews

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Tetrazoles via Multicomponent Reactions
Open Access Through ACS AuthorChoice
Chem. Rev., 2019, 119 (3), pp 1970–2042
DOI: 10.1021/acs.chemrev.8b00564

Catalysis with Two-Dimensional Materials Confining Single Atoms: Concept, Design, and Applications
Chem. Rev., 2019, 119 (3), pp 1806–1854
DOI: 10.1021/acs.chemrev.8b00501

3d Transition Metals for C–H Activation
This article is part of the First Row Metals and Catalysis special issue.
Chem. Rev., 2019, 119 (4), pp 2192–2452
DOI: 10.1021/acs.chemrev.8b00507

Singlet Molecular Oxygen Reactions with Nucleic Acids, Lipids, and Proteins
Chem. Rev., 2019, 119 (3), pp 2043–2086
DOI: 10.1021/acs.chemrev.8b00554

Versatile Types of Organic/Inorganic Nanohybrids: From Strategic Design to Biomedical Applications
Chem. Rev., 2019, 119 (3), pp 1666–1762
DOI: 10.1021/acs.chemrev.8b00401


Journal of the American Chemical Society

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Total Synthesis of Pentacyclic (−)-Ambiguine P Using Sequential Indole Functionalizations
J. Am. Chem. Soc., 2019, 141 (6), pp 2233–2237
DOI: 10.1021/jacs.8b13388

Asymmetric Total Synthesis of Cerorubenic Acid-III
J. Am. Chem. Soc., 2019, 141 (7), pp 2872–2877
DOI: 10.1021/jacs.8b12647

Catalytic Hydrothiolation: Counterion-Controlled Regioselectivity
J. Am. Chem. Soc., 2019, 141 (7), pp 3006–3013
DOI: 10.1021/jacs.8b11395

DNA-Functionalized Metal–Organic Framework Nanoparticles for Intracellular Delivery of Proteins
J. Am. Chem. Soc., 2019, 141 (6), pp 2215–2219
DOI: 10.1021/jacs.8b12705

Alkenyl Exchange of Allylamines via Nickel(0)-Catalyzed C–C Bond Cleavage
J. Am. Chem. Soc., 2019, 141 (7), pp 2889–2893
DOI: 10.1021/jacs.8b13251


Journal of Chemical Education

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Evidence for the Importance of Laboratory Courses
J. Chem. Educ., 2019, 96 (2), pp 193–195
DOI: 10.1021/acs.jchemed.8b00874

A Digital Periodic Table That Instructors Can Use in the Classroom To Highlight Elements and Illustrate Periodic Trends
J. Chem. Educ., 2019, 96 (2), pp 387–389
DOI: 10.1021/acs.jchemed.8b00616

Consensus, Division, and the Future of Graduate Education in the Chemical Sciences
J. Chem. Educ., 2019, 96 (2), pp 196–202
DOI: 10.1021/acs.jchemed.8b00642

Applying Chemistry Knowledge to Code, Construct, and Demonstrate an Arduino–Carbon Dioxide Fountain
Open Access Through ACS AuthorChoice
J. Chem. Educ., 2019, 96 (2), pp 313–316
DOI: 10.1021/acs.jchemed.8b00663

Measuring CO2 with an Arduino: Creating a Low-Cost, Pocket-Sized Device with Flexible Applications That Yields Benefits for Students and Schools
J. Chem. Educ., 2019, 96 (2), pp 377–381
DOI: 10.1021/acs.jchemed.8b00473

Discover the Most-Read Materials Science and Engineering Articles of February 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in February 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Get free monthly updates on the most-read research in your field.

Read more of February’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical


ACS Applied Materials & Interfaces

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Stimuli-Responsive Conductive Nanocomposite Hydrogels with High Stretchability, Self-Healing, Adhesiveness, and 3D Printability for Human Motion Sensing
ACS Appl. Mater. Interfaces, 2019, 11 (7), pp 6796–6808
DOI: 10.1021/acsami.8b20178

Recent Advances in Flexible and Wearable Pressure Sensors Based on Piezoresistive 3D Monolithic Conductive Sponges
ACS Appl. Mater. Interfaces, 2019, 11 (7), pp 6685–6704
DOI: 10.1021/acsami.8b20929

Learning from Natural Leaves: Going Green with Artificial Photosynthesis Forum
This article is part of the Artificial Photosynthesis: Harnessing Materials and Interfaces for Sustainable Fuels special issue.
ACS Appl. Mater. Interfaces, 2019, 11 (6), pp 5579–5580
DOI: 10.1021/acsami.9b00245

Microdrop-Assisted Microdomain Hydrophilicization of Superhydrophobic Surfaces for High-Efficiency Nucleation and Self-Removal of Condensate Microdrops
Open Access Through ACS Editors’ Choice
ACS Appl. Mater. Interfaces, 2019, 11 (7), pp 7553–7558
DOI: 10.1021/acsami.8b19868

Simple near-Infrared Nonfullerene Acceptors Enable Organic Solar Cells with >9% Efficiency
ACS Appl. Mater. Interfaces, 2019, 11 (7), pp 6717–6723
DOI: 10.1021/acsami.8b20567


ACS Applied Bio Materials

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Controlled Release of Silver Nanoparticles Contained in Photoresponsive Nanogels
ACS Appl. Bio Mater., 2019, 2 (2), pp 644–653
DOI: 10.1021/acsabm.8b00366

Supramolecular Switching Surface for Antifouling and Bactericidal Activities
ACS Appl. Bio Mater., 2019, 2 (2), pp 638–643
DOI: 10.1021/acsabm.8b00831

Polydopamine-Based Multifunctional Platform for Combined Photothermal Therapy, Chemotherapy, and Immunotherapy in Malignant Tumor Treatment
ACS Appl. Bio Mater., 2019, 2 (2), pp 874–883
DOI: 10.1021/acsabm.8b00718

Tailoring the Bactericidal Activity of Ag Nanoparticles/α-Ag2WO4 Composite Induced by Electron Beam and Femtosecond Laser Irradiation: Integration of Experiment and Computational Modeling
ACS Appl. Bio Mater., 2019, 2 (2), pp 824–837
DOI: 10.1021/acsabm.8b00673

Porous Organic Polymer-Coated Band-Aids for Phototherapy of Bacteria-Induced Wound Infection
ACS Appl. Bio Mater., 2019, 2 (2), pp 613–618
DOI: 10.1021/acsabm.8b00676


ACS Applied Electronic Materials

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Low Operating Voltage and Highly Pressure-Sensitive Printed Sensor for Healthcare Monitoring with Analogic Amplifier Circuit
ACS Appl. Electron. Mater., 2019, 1 (2), pp 246–252
DOI: 10.1021/acsaelm.8b00088

Growth Window of Ferroelectric Epitaxial Hf0.5Zr0.5O2 Thin Films
ACS Appl. Electron. Mater., 2019, 1 (2), pp 220–228
DOI: 10.1021/acsaelm.8b00065

Bandwidth Limitation of Directly Contacted Graphene–Silicon Optoelectronics
ACS Appl. Electron. Mater., 2019, 1 (2), pp 172–178
DOI: 10.1021/acsaelm.8b00015

Contact Engineering for Dual-Gate MoS2 Transistors Using O2 Plasma Exposure
ACS Appl. Electron. Mater., 2019, 1 (2), pp 210–219
DOI: 10.1021/acsaelm.8b00059

Highly Crystalline Single-Walled Carbon Nanotube Field Emitters: Energy-Loss-Free High Current Output and Long Durability with High Power
ACS Appl. Electron. Mater., 2019, 1 (2), pp 163–171
DOI: 10.1021/acsaelm.8b00008


ACS Applied Energy Materials

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Nascent SEI-Surface Films on Single Crystalline Silicon Investigated by Scanning Electrochemical Microscopy
ACS Appl. Energy Mater., 2019, 2 (2), pp 1388–1392
DOI: 10.1021/acsaem.8b01967

Overcoming the High-Voltage Limitations of Li-Ion Batteries Using a Titanium Nitride Current Collector
Open Access Through ACS AuthorChoice
ACS Appl. Energy Mater., 2019, 2 (2), pp 974–978
DOI: 10.1021/acsaem.8b01771

Strain Effects on Oxygen Reduction Activity of Pr2NiO4 Caused by Gold Bulk Dispersion for Low Temperature Solid Oxide Fuel Cells
ACS Appl. Energy Mater., 2019, 2 (2), pp 1210–1220
DOI: 10.1021/acsaem.8b01776

Flame Aerosol Synthesis and Electrochemical Characterization of Ni-Rich Layered Cathode Materials for Li-Ion Batteries
Open Access Through ACS AuthorChoice
ACS Appl. Energy Mater., 2019, 2 (2), pp 1319–1329
DOI: 10.1021/acsaem.8b01892

Fiber-Shaped Electrochemical Capacitors Based on Plasma-Engraved Graphene Fibers with Oxygen Vacancies for Alternating Current Line Filtering Performance
ACS Appl. Energy Mater., 2019, 2 (2), pp 993–999
DOI: 10.1021/acsaem.8b02060


ACS Applied Nano Materials

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Toward Base Heterogenization: A Zirconium Metal–Organic Framework/Dendrimer or Polymer Mixture for Rapid Hydrolysis of a Nerve-Agent Simulant
ACS Appl. Nano Mater., 2019, 2 (2), pp 1005–1008
DOI: 10.1021/acsanm.8b02292

Multiwalled Carbon Nanotube Reinforced Epoxy Nanocomposites for Vibration Damping
ACS Appl. Nano Mater., 2019, 2 (2), pp 736–743
DOI: 10.1021/acsanm.8b01865

Three-Dimensional Nanoscale Mapping of Porosity in Solution-Processed ITO Multilayer Thin Films for Patternable Transparent Electrodes
ACS Appl. Nano Mater., 2019, 2 (2), pp 726–735
DOI: 10.1021/acsanm.8b01873

Dynamically Switching the Electronic and Electrostatic Properties of Indium–Tin Oxide Electrodes with Photochromic Monolayers: Toward Photoswitchable Optoelectronic Devices
ACS Appl. Nano Mater., 2019, 2 (2), pp 1102–1110
DOI: 10.1021/acsanm.9b00094

Gold-Tagged Polymeric Nanoparticles with Spatially Controlled Composition for Enhanced Detectability in Biological Environments
ACS Appl. Nano Mater., 2019, 2 (2), pp 917–926
DOI: 10.1021/acsanm.8b02165


ACS Applied Polymer Materials

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Fluorescent Patterns by Selective Grafting of a Telechelic Polymer
Open Access Through ACS AuthorChoice
ACS Appl. Polym. Mater., 2019, 1 (2), pp 136–140
DOI: 10.1021/acsapm.8b00180

Externally Triggered Heat and Drug Release from Magnetically Controlled Nanocarriers
ACS Appl. Polym. Mater., 2019, 1 (2), pp 211–220
DOI: 10.1021/acsapm.8b00100

Environmentally Friendly Method To Prepare Thermo-Reversible, Self-Healable Biobased Elastomers by One-Step Melt Processing
ACS Appl. Polym. Mater., 2019, 1 (2), pp 169–177
DOI: 10.1021/acsapm.8b00040

Bio-Inspired Structural Colors Based on Linear Ultrahigh Molecular Weight Block Copolymers
ACS Appl. Polym. Mater., 2019, 1 (2), pp 239–250
DOI: 10.1021/acsapm.8b00169

Hydrophilic Organic Redox-Active Polymer Nanoparticles for Higher Energy Density Flow Batteries
ACS Appl. Polym. Mater., 2019, 1 (2), pp 188–196
DOI: 10.1021/acsapm.8b00074


ACS Biomaterials Science & Engineering

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A Trans-Atlantic Perspective on Stagnation in Clinical Translation of Antimicrobial Strategies for the Control of Biomaterial-Implant-Associated Infection
Open Access Through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2019, 5 (2), pp 402–406
DOI: 10.1021/acsbiomaterials.8b01071

Optimizing Blended Collagen-Fibrin Hydrogels for Cardiac Tissue Engineering with Human iPSC-derived Cardiomyocytes
Open Access Through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2019, 5 (2), pp 887–899
DOI: 10.1021/acsbiomaterials.8b01112

Surface-Potential-Controlled Cell Proliferation and Collagen Mineralization on Electrospun Polyvinylidene Fluoride (PVDF) Fiber Scaffolds for Bone Regeneration
ACS Biomater. Sci. Eng., 2019, 5 (2), pp 582–593
DOI: 10.1021/acsbiomaterials.8b01108

In Vivo Evaluation of Engineered Self-Assembling Silk Fibroin Hydrogels after Intracerebral Injection in a Rat Stroke Model
Open Access Through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2019, 5 (2), pp 859–869
DOI: 10.1021/acsbiomaterials.8b01024

Cancellous-Bone-like Porous Iron Scaffold Coated with Strontium Incorporated Octacalcium Phosphate Nanowhiskers for Bone Regeneration
ACS Biomater. Sci. Eng., 2019, 5 (2), pp 509–518
DOI: 10.1021/acsbiomaterials.8b01188


ACS Catalysis

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Synthesis of α-Fluoro-α-amino Acid Derivatives via Photoredox-Catalyzed Carbofluorination
ACS Catal., 2019, 9 (2), pp 1558–1563
DOI: 10.1021/acscatal.8b04284

Effective Use of Renewable Electricity for Making Renewable Fuels and Chemicals
ACS Catal., 2019, 9 (2), pp 946–950
DOI: 10.1021/acscatal.8b04143

What Is Measured When Measuring Acidity in Zeolites with Probe Molecules?
Open Access Through ACS AuthorChoice
ACS Catal., 2019, 9 (2), pp 1539–1548
DOI: 10.1021/acscatal.8b04317

Carbonyl–Olefin Metathesis Catalyzed by Molecular Iodine
ACS Catal., 2019, 9 (2), pp 912–919
DOI: 10.1021/acscatal.8b03769

Visible-Light-Mediated Regioselective Chlorosulfonylation of Alkenes and Alkynes: Introducing the Cu(II) Complex [Cu(dap)Cl2] to Photochemical ATRA Reactions
ACS Catal., 2019, 9 (2), pp 1103–1109
DOI: 10.1021/acscatal.8b04188


ACS Energy Letters

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Citation Mania: The Good, the Bad, and the Ugly
ACS Energy Lett., 2019, 4 (2), pp 471–472
DOI: 10.1021/acsenergylett.9b00016

Status and Outlook for Magnesium Battery Technologies: A Conversation with Stan Whittingham and Sarbajit Banerjee
ACS Energy Lett., 2019, 4 (2), pp 572–575
DOI: 10.1021/acsenergylett.9b00214

Quaternary Layered Ni-Rich NCMA Cathode for Lithium-Ion Batteries
ACS Energy Lett., 2019, 4 (2), pp 576–582
DOI: 10.1021/acsenergylett.8b02499

Photochemical Conversion and Storage of Solar Energy
ACS Energy Lett., 2019, 4 (2), pp 405–410
DOI: 10.1021/acsenergylett.8b02411

Interphase Morphology between a Solid-State Electrolyte and Lithium Controls Cell Failure
ACS Energy Lett., 2019, 4 (2), pp 591–599
DOI: 10.1021/acsenergylett.9b00093


ACS Macro Letters

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Photoinitiated Polymerization-Induced Self-Assembly via Visible Light-Induced RAFT-Mediated Emulsion Polymerization
ACS Macro Lett., 2019, 8 (2), pp 205–212
DOI: 10.1021/acsmacrolett.9b00007

Integrating Sacrificial Bonds into Dynamic Covalent Networks toward Mechanically Robust and Malleable Elastomers
ACS Macro Lett., 2019, 8 (2), pp 193–199
DOI: 10.1021/acsmacrolett.9b00012

Supramolecular Emulsion Interfacial Polymerization
ACS Macro Lett., 2019, 8 (2), pp 177–182
DOI: 10.1021/acsmacrolett.8b01003

Phosphate-Based Cross-Linked Polymers from Iodo–ene Photopolymerization: Tuning Surface Wettability through Thiol–ene Chemistry
ACS Macro Lett., 2019, 8 (2), pp 213–217
DOI: 10.1021/acsmacrolett.8b00934

Catalyst-Free Click Polymerization of CO2 and Lewis Monomers for Recyclable C1 Fixation and Release
ACS Macro Lett., 2019, 8 (2), pp 200–204
DOI: 10.1021/acsmacrolett.9b00066


ACS Nano

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Reversible Self-Assembly of Nanoprobes in Live Cells for Dynamic Intracellular pH Imaging
ACS Nano, 2019, 13 (2), pp 1421–1432
DOI: 10.1021/acsnano.8b07054

Cerium Based Metal–Organic Frameworks as an Efficient Separator Coating Catalyzing the Conversion of Polysulfides for High Performance Lithium–Sulfur Batteries
ACS Nano, 2019, 13 (2), pp 1923–1931
DOI: 10.1021/acsnano.8b08155

Magnetic Nanoclusters Armed with Responsive PD-1 Antibody Synergistically Improved Adoptive T-Cell Therapy for Solid Tumors
ACS Nano, 2019, 13 (2), pp 1469–1478
DOI: 10.1021/acsnano.8b07141

Therapeutic Polymersome Nanoreactors with Tumor-Specific Activable Cascade Reactions for Cooperative Cancer Therapy
ACS Nano, 2019, 13 (2), pp 2357–2369
DOI: 10.1021/acsnano.8b09082

Extrinsic and Dynamic Edge States of Two-Dimensional Lead Halide Perovskites
ACS Nano, 2019, 13 (2), pp 1635–1644
DOI: 10.1021/acsnano.8b07631


ACS Photonics

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Quantifying Figures of Merit for Localized Surface Plasmon Resonance Applications: A Materials Survey
ACS Photonics, 2019, 6 (2), pp 240–259
DOI: 10.1021/acsphotonics.8b01369

Limits to Strong Coupling of Excitons in Multilayer WS2 with Collective Plasmonic Resonances
ACS Photonics, 2019, 6 (2), pp 286–293
DOI: 10.1021/acsphotonics.8b01459

Radiation of Dynamic Toroidal Moments
Open Access Through ACS AuthorChoice
ACS Photonics, 2019, 6 (2), pp 467–474
DOI: 10.1021/acsphotonics.8b01422

In Situ Fabrication of 2D WS2/Si Type-II Heterojunction for Self-Powered Broadband Photodetector with Response up to Mid-Infrared
Open Access Through ACS Editors’ Choice
ACS Photonics, 2019, 6 (2), pp 565–572
DOI: 10.1021/acsphotonics.8b01675

Strained Bubbles in van der Waals Heterostructures as Local Emitters of Photoluminescence with Adjustable Wavelength
ACS Photonics, 2019, 6 (2), pp 516–524
DOI: 10.1021/acsphotonics.8b01497


ACS Sensors

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Generic Neutravidin Biosensor for Simultaneous Multiplex Detection of MicroRNAs via Electrochemically Encoded Responsive Nanolabels
ACS Sens., 2019, 4 (2), pp 326–334
DOI: 10.1021/acssensors.8b00942

Breath Sensors for Health Monitoring
ACS Sens., 2019, 4 (2), pp 268–280
DOI: 10.1021/acssensors.8b00937

A Novel Carbon Quantum Dots Signal Amplification Strategy Coupled with Sandwich Electrochemiluminescence Immunosensor for the Detection of CA15-3 in Human Serum
ACS Sens., 2019, 4 (2), pp 504–512
DOI: 10.1021/acssensors.8b01607

Hydrazine Exposé: The Next-Generation Fluorescent Probe
ACS Sens., 2019, 4 (2), pp 441–449
DOI: 10.1021/acssensors.8b01429

Visualization of Sulfane Sulfur in Plants with a Near-Infrared Fluorescent Probe
ACS Sens., 2019, 4 (2), pp 434–440
DOI: 10.1021/acssensors.8b01423


ACS Sustainable Chemistry & Engineering

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Use of Supercritical Water for the Liquefaction of Polypropylene into Oil
ACS Sustainable Chem. Eng., 2019, 7 (4), pp 3749–3758
DOI: 10.1021/acssuschemeng.8b03841

Catalytic Byproduct Valorization in Future Biorefineries
ACS Sustainable Chem. Eng., 2019, 7 (3), pp 2878–2878
DOI: 10.1021/acssuschemeng.9b00106

A Search for Natural Hydrophobic Deep Eutectic Solvents Based on Natural Components
Open Access Through ACS AuthorChoice
ACS Sustainable Chem. Eng., 2019, 7 (3), pp 2933–2942
DOI: 10.1021/acssuschemeng.8b03520

Enhancing Electrocatalytic N2 Reduction to NH3 by CeO2 Nanorod with Oxygen Vacancies
ACS Sustainable Chem. Eng., 2019, 7 (3), pp 2889–2893
DOI: 10.1021/acssuschemeng.8b05007

Scalable and Sustainable Synthesis of Advanced Porous Materials
ACS Sustainable Chem. Eng., 2019, 7 (4), pp 3647–3670
DOI: 10.1021/acssuschemeng.8b05463


Bioconjugate Chemistry

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Delivery of Proteins and Nucleic Acids: Achievements and Challenges
This article is part of the Delivery of Proteins and Nucleic Acids: Achievements and Challenges special issue.
Bioconjugate Chem., 2019, 30 (2), pp 261–262
DOI: 10.1021/acs.bioconjchem.9b00096

Overcoming Endosomal Entrapment in Drug Delivery
This article is part of the Delivery of Proteins and Nucleic Acids: Achievements and Challenges special issue.
Bioconjugate Chem., 2019, 30 (2), pp 273–283
DOI: 10.1021/acs.bioconjchem.8b00778

The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery
This article is part of the Delivery of Proteins and Nucleic Acids: Achievements and Challenges special issue.
Bioconjugate Chem., 2019, 30 (2), pp 263–272
DOI: 10.1021/acs.bioconjchem.8b00732

Bioconjugated Oligonucleotides: Recent Developments and Therapeutic Applications
This article is part of the Delivery of Proteins and Nucleic Acids: Achievements and Challenges special issue.
Bioconjugate Chem., 2019, 30 (2), pp 366–383
DOI: 10.1021/acs.bioconjchem.8b00761

Recent Advances in Anti-cancer Protein/Peptide Delivery
Bioconjugate Chem., 2019, 30 (2), pp 305–324
DOI: 10.1021/acs.bioconjchem.8b00750


Biomacromolecules

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Synthetic Extracellular Matrices with Nonlinear Elasticity Regulate Cellular Organization
Open Access Through ACS AuthorChoice
Biomacromolecules, 2019, 20 (2), pp 826–834
DOI: 10.1021/acs.biomac.8b01445

Rational Design of Multifunctional Renewable-Resourced Materials
This article is part of the The Rational Design of Multifunctional Renewable-Resourced Materials special issue.
Biomacromolecules, 2019, 20 (2), pp 569–572
DOI: 10.1021/acs.biomac.9b00060

Injectable, Self-Healing, and Multi-Responsive Hydrogels via Dynamic Covalent Bond Formation between Benzoxaborole and Hydroxyl Groups
Biomacromolecules, 2019, 20 (2), pp 1028–1035
DOI: 10.1021/acs.biomac.8b01652

Current State and New Trends in the Use of Cellulose Nanomaterials for Wastewater Treatment
This article is part of the The Rational Design of Multifunctional Renewable-Resourced Materials special issue.
Biomacromolecules, 2019, 20 (2), pp 573–597
DOI: 10.1021/acs.biomac.8b00839

Sustainable Chitin Nanofibrils Provide Outstanding Flame-Retardant Nanopapers
Biomacromolecules, 2019, 20 (2), pp 1098–1108
DOI: 10.1021/acs.biomac.8b01766


Chemistry of Materials

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ACS Applied Materials & Interfaces and Chemistry of Materials To Exclusively Publish Full Articles in 2019
Chem. Mater., 2019, 31 (3), pp 563–564
DOI: 10.1021/acs.chemmater.9b00022

Are Chalcogenide Perovskites an Emerging Class of Semiconductors for Optoelectronic Properties and Solar Cell?
Chem. Mater., 2019, 31 (3), pp 565–575
DOI: 10.1021/acs.chemmater.8b04178

Silicon Nanoparticles: Are They Crystalline from the Core to the Surface?
Chem. Mater., 2019, 31 (3), pp 678–688
DOI: 10.1021/acs.chemmater.8b03074

Photocatalytic Gas Phase Reactions
Chem. Mater., 2019, 31 (3), pp 597–618
DOI: 10.1021/acs.chemmater.8b04444

Core–Shell Structured Cyclodextrin Metal–Organic Frameworks with Hierarchical Dye Encapsulation for Tunable Light Emission
Chem. Mater., 2019, 31 (4), pp 1289–1295
DOI: 10.1021/acs.chemmater.8b04126


Crystal Growth & Design

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A Practical Guide to the Design of Molecular Crystals
Published as part of a Crystal Growth and Design virtual special issue Honoring Prof. William Jones and His Contributions to Organic Solid-State Chemistry
Open Access Through ACS Editors’ Choice
Cryst. Growth Des., 2019, 19 (2), pp 1426–1453
DOI: 10.1021/acs.cgd.8b00972

Joel Bernstein (1941–2019)
Cryst. Growth Des., 2019, 19 (2), pp 521–522
DOI: 10.1021/acs.cgd.9b00060

The Nature and Applications of π–π Interactions: A Perspective
Published as part of a Crystal Growth and Design virtual special issue on π−π Stacking in Crystal Engineering: Fundamentals and Applications
Cryst. Growth Des., 2019, 19 (2), pp 523–528
DOI: 10.1021/acs.cgd.8b01630

Fabrication of Desired Metal–Organic Frameworks via Postsynthetic Exchange and Sequential Linker Installation
Published as part of a Crystal Growth and Design virtual special issue on Crystalline Functional Materials in Honor of Professor Xin-Tao Wu
Cryst. Growth Des., 2019, 19 (2), pp 1454–1470
DOI: 10.1021/acs.cgd.8b01628

The Curious Case of Acetaldehyde Phenylhydrazone: Resolution of a 120 Year Old Puzzle where Forms with Vastly Different Melting Points Have the Same Structure
Open Access Through ACS AuthorChoice
Cryst. Growth Des., 2019, 19 (2), pp 907–917
DOI: 10.1021/acs.cgd.8b01459


Energy & Fuels

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Electrochemically Assisted Deposition of Calcite for Application in Surfactant Adsorption Studies
Energy Fuels, 2019, 33 (2), pp 805–813
DOI: 10.1021/acs.energyfuels.8b03572

Liquefaction of Lignosulfonate in Supercritical Ethanol Using Alumina-Supported NiMo Catalyst
Open Access Through ACS Editors’ Choice
Energy Fuels, 2019, 33 (2), pp 1196–1209
DOI: 10.1021/acs.energyfuels.8b03519

Nanopyroxene-Based Nanofluids for Enhanced Oil Recovery in Sandstone Cores at Reservoir Temperature
Energy Fuels, 2019, 33 (2), pp 877–890
DOI: 10.1021/acs.energyfuels.8b03749

Optimal Applications and Combinations of Renewable Fuel Production from Biomass and Electricity
Energy Fuels, 2019, 33 (2), pp 1659–1672
DOI: 10.1021/acs.energyfuels.8b03790

Investigation into the Effect of Heteroatom Content on Kerogen Structure Using Advanced 13C Solid-State Nuclear Magnetic Resonance Spectroscopy
Energy Fuels, 2019, 33 (2), pp 645–653
DOI: 10.1021/acs.energyfuels.8b01909


Industrial & Engineering Chemistry Research

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High Pressure Electrochemical Reduction of CO2 to Formic Acid/Formate: A Comparison between Bipolar Membranes and Cation Exchange Membranes
Open Access Through ACS AuthorChoice
Ind. Eng. Chem. Res., 2019, 58 (5), pp 1834–1847
DOI: 10.1021/acs.iecr.8b04944

Kinetic Study of Homogeneous Catalyzed Esterification of a Series of Aliphatic Acids with Different Alcohols
Ind. Eng. Chem. Res., 2019, 58 (8), pp 2672–2682
DOI: 10.1021/acs.iecr.8b04781

Esterification of Methacrylic Acid with Methanol: Process Optimization, Kinetic Modeling, and Reactive Distillation
Ind. Eng. Chem. Res., 2019, 58 (6), pp 2135–2145
DOI: 10.1021/acs.iecr.8b03842

Mesoporous Manganese Dioxide Coated Gold Nanorods as a Multiresponsive Nanoplatform for Drug Delivery
Ind. Eng. Chem. Res., 2019, 58 (8), pp 2991–2999
DOI: 10.1021/acs.iecr.8b05331

Process Design Alternatives for Producing Ultra-high-purity Electronic-Grade Propylene Glycol Monomethyl Ether Acetate
Ind. Eng. Chem. Res., 2019, 58 (6), pp 2246–2257
DOI: 10.1021/acs.iecr.8b04052


Inorganic Chemistry

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Actinide Chemistry at the Extreme
Inorg. Chem., 2019, 58 (3), pp 1721–1723
DOI: 10.1021/acs.inorgchem.8b03603

Effects of Lewis Acidic Metal Ions (M) on Oxygen-Atom Transfer Reactivity of Heterometallic Mn3MO4 Cubane and Fe3MO(OH) and Mn3MO(OH) Clusters
Inorg. Chem., 2019, 58 (4), pp 2336–2345
DOI: 10.1021/acs.inorgchem.8b02701

Histidine Targeting Heterobimetallic Ruthenium(II)–Gold(I) Complexes
Open Access Through ACS AuthorChoice
Inorg. Chem., 2019, 58 (4), pp 2501–2513
DOI: 10.1021/acs.inorgchem.8b03069

Luminescent Ruthenium(II) Polypyridine Complexes for a Wide Variety of Biomolecular and Cellular Applications
Inorg. Chem., 2019, 58 (4), pp 2231–2247
DOI: 10.1021/acs.inorgchem.8b02979

Superhydrophobic/Superoleophilic MOF Composites for Oil–Water Separation
Inorg. Chem., 2019, 58 (4), pp 2261–2264
DOI: 10.1021/acs.inorgchem.8b03293


Journal of Chemical & Engineering Data

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Editorial: Guidelines for the Measurement of Solid–Liquid Solubility Data at Atmospheric Pressure
J. Chem. Eng. Data, 2019, 64 (2), pp 381–385
DOI: 10.1021/acs.jced.8b01263

Viscosities of Liquid Hexadecane at Temperatures between 323 K and 673 K and Pressures up to 4 MPa Measured Using a Dual-Capillary Viscometer
J. Chem. Eng. Data, 2019, 64 (2), pp 706–712
DOI: 10.1021/acs.jced.8b00930

Molecular Dynamics Study of Adsorption of the Lennard-Jones Truncated and Shifted Fluid on Planar Walls
Published as part of The Journal of Chemical and Engineering Data special issue “Proceedings of the 20th Symposium on Thermophysical Properties”
J. Chem. Eng. Data, 2019, 64 (2), pp 386–394
DOI: 10.1021/acs.jced.8b00927

Viscosity and Density of Binary Mixtures of Ethanol + Igepal (CO-520, CO-630, CO-720, and CA-720)
J. Chem. Eng. Data, 2019, 64 (2), pp 594–602
DOI: 10.1021/acs.jced.8b00793

Thermodynamic Study of Four {Methylpiperidine + Water} Systems: New Experimental Data and Challenging Modeling for the Simultaneous Representation of Liquid–Liquid Equilibrium and Energetic Properties
J. Chem. Eng. Data, 2019, 64 (2), pp 743–754
DOI: 10.1021/acs.jced.8b00974


The Journal of Physical Chemistry C

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Tunneling Diffusion of Excess Protons in Amorphous Solid Water at 10 and 80 K
J. Phys. Chem. C, 2019, 123 (6), pp 3657–3663
DOI: 10.1021/acs.jpcc.8b11829

Emerging Design Principles for Enhanced Solar Energy Utilization with Singlet Fission
J. Phys. Chem. C, 2019, 123 (7), pp 3923–3934
DOI: 10.1021/acs.jpcc.8b10876

Cu-Based Single-Atom Catalysts Boost Electroreduction of CO2 to CH3OH: First-Principles Predictions
J. Phys. Chem. C, 2019, 123 (7), pp 4380–4387
DOI: 10.1021/acs.jpcc.8b12449

Photoexcited Dynamics in Metal Halide Perovskites: From Relaxation Mechanisms to Applications
J. Phys. Chem. C, 2019, 123 (6), pp 3255–3269
DOI: 10.1021/acs.jpcc.8b11347

Electrodes as Polarizing Functional Groups: Correlation between Hammett Parameters and Electrochemical Polarization
J. Phys. Chem. C, 2019, 123 (8), pp 4926–4937
DOI: 10.1021/acs.jpcc.8b12058


The Journal of Physical Chemistry Letters

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Photocatalytic and Photoelectrochemical Degradation of Organic Compounds with All-Inorganic Metal Halide Perovskite Quantum Dots
Open Access Through ACS Editors’ Choice
J. Phys. Chem. Lett., 2019, 10 (3), pp 630–636
DOI: 10.1021/acs.jpclett.8b03849

Chinese Spring Festival Editorial
J. Phys. Chem. Lett., 2019, 10 (3), pp 701–701
DOI: 10.1021/acs.jpclett.9b00263

Highly Efficient Ultralong Organic Phosphorescence through Intramolecular-Space Heavy-Atom Effect
J. Phys. Chem. Lett., 2019, 10 (3), pp 595–600
DOI: 10.1021/acs.jpclett.8b03712

Nonsymmetrical Connection of Two Identical Building Blocks: Constructing Donor–Acceptor Molecules as Deep Blue Emitting Materials for Efficient Organic Emitting Diodes
J. Phys. Chem. Lett., 2019, 10 (4), pp 842–847
DOI: 10.1021/acs.jpclett.9b00300

Less Is More: Dilution Enhances Optical and Electrical Performance of a TADF Exciplex
J. Phys. Chem. Lett., 2019, 10 (4), pp 793–798
DOI: 10.1021/acs.jpclett.8b03646


Langmuir

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Romantic Surfaces: A Systematic Overview of Stable, Biospecific, and Antifouling Zwitterionic Surfaces
Open Access Through ACS AuthorChoice
This article is part of the Zwitterionic Interfaces: Concepts and Emerging Applications special issue.
Langmuir, 2019, 35 (5), pp 1072–1084
DOI: 10.1021/acs.langmuir.8b03360

Zwitterionic Interfaces: Concepts and Emerging Applications Special Issue
This article is part of the Zwitterionic Interfaces: Concepts and Emerging Applications special issue.
Langmuir, 2019, 35 (5), pp 1055–1055
DOI: 10.1021/acs.langmuir.8b04183

Morphology of Evaporating Sessile Microdroplets on Lyophilic Elliptical Patches
Open Access Through ACS AuthorChoice
Langmuir, 2019, 35 (6), pp 2099–2105
DOI: 10.1021/acs.langmuir.8b03393

Kinetics of Nanoparticle–Membrane Adhesion Mediated by Multivalent Interactions
Langmuir, 2019, 35 (6), pp 2002–2012
DOI: 10.1021/acs.langmuir.8b02707

Molecular Design of Zwitterionic Polymer Interfaces: Searching for the Difference
This article is part of the Zwitterionic Interfaces: Concepts and Emerging Applications special issue.
Langmuir, 2019, 35 (5), pp 1056–1071
DOI: 10.1021/acs.langmuir.8b01789


Macromolecules

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Modeling and Simulations of Polymers: A Roadmap
Open Access Through ACS Editors’ Choice
Macromolecules, 2019, 52 (3), pp 755–786
DOI: 10.1021/acs.macromol.8b01836

Porous Polystyrene Monoliths Prepared from in Situ Simultaneous Interpenetrating Polymer Networks: Modulation of Morphology by Polymerization Kinetics
Open Access Through ACS AuthorChoice
Macromolecules, 2019, 52 (3), pp 819–826
DOI: 10.1021/acs.macromol.8b01923

Structural and Dimensional Transformations between Covalent Organic Frameworks via Linker Exchange
Macromolecules, 2019, 52 (3), pp 1257–1265
DOI: 10.1021/acs.macromol.8b01814

Poly(vinylpyridine) Segments in Block Copolymers: Synthesis, Self-Assembly, and Versatility
Open Access Through ACS Editors’ Choice
Macromolecules, 2019, 52 (4), pp 1354–1370
DOI: 10.1021/acs.macromol.8b01661

Unraveling Polymer Structures with RAFT Polymerization and Diels–Alder Chemistry
Macromolecules, 2019, 52 (3), pp 1308–1316
DOI: 10.1021/acs.macromol.8b01967


Nano Letters

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Wrinkled Graphene Cages as Hosts for High-Capacity Li Metal Anodes Shown by Cryogenic Electron Microscopy
Nano Lett., 2019, 19 (2), pp 1326–1335
DOI: 10.1021/acs.nanolett.8b04906

Imaging Three-Dimensional Elemental Inhomogeneity in Pt–Ni Nanoparticles Using Spectroscopic Single Particle Reconstruction
Nano Lett., 2019, 19 (2), pp 732–738
DOI: 10.1021/acs.nanolett.8b03768

Amplification of Tumor Oxidative Stresses with Liposomal Fenton Catalyst and Glutathione Inhibitor for Enhanced Cancer Chemotherapy and Radiotherapy
Nano Lett., 2019, 19 (2), pp 805–815
DOI: 10.1021/acs.nanolett.8b03905

Enhanced Drug Delivery by Nanoscale Integration of a Nitric Oxide Donor To Induce Tumor Collagen Depletion
Nano Lett., 2019, 19 (2), pp 997–1008
DOI: 10.1021/acs.nanolett.8b04236

On-Chip Detection of Optical Spin–Orbit Interactions in Plasmonic Nanocircuits
Nano Lett., 2019, 19 (2), pp 1166–1171
DOI: 10.1021/acs.nanolett.8b04611

Discover the Most-Read Biological Chemistry Articles of February 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in February 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Get free monthly updates on the most-read research in your field.

Read more of February’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical
ACS Applied Bio Materials

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Controlled Release of Silver Nanoparticles Contained in Photoresponsive Nanogels
ACS Appl. Bio Mater., 2019, 2 (2), pp 644–653
DOI: 10.1021/acsabm.8b00366

Supramolecular Switching Surface for Antifouling and Bactericidal Activities
ACS Appl. Bio Mater., 2019, 2 (2), pp 638–643
DOI: 10.1021/acsabm.8b00831

Polydopamine-Based Multifunctional Platform for Combined Photothermal Therapy, Chemotherapy, and Immunotherapy in Malignant Tumor Treatment
ACS Appl. Bio Mater., 2019, 2 (2), pp 874–883
DOI: 10.1021/acsabm.8b00718

Tailoring the Bactericidal Activity of Ag Nanoparticles/α-Ag2WO4 Composite Induced by Electron Beam and Femtosecond Laser Irradiation: Integration of Experiment and Computational Modeling
ACS Appl. Bio Mater., 2019, 2 (2), pp 824–837
DOI: 10.1021/acsabm.8b00673

Porous Organic Polymer-Coated Band-Aids for Phototherapy of Bacteria-Induced Wound Infection
ACS Appl. Bio Mater., 2019, 2 (2), pp 613–618
DOI: 10.1021/acsabm.8b00676


ACS Biomaterials Science & Engineering

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A Trans-Atlantic Perspective on Stagnation in Clinical Translation of Antimicrobial Strategies for the Control of Biomaterial-Implant-Associated Infection
Open Access Through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2019, 5 (2), pp 402–406
DOI: 10.1021/acsbiomaterials.8b01071

Optimizing Blended Collagen-Fibrin Hydrogels for Cardiac Tissue Engineering with Human iPSC-derived Cardiomyocytes
Open Access Through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2019, 5 (2), pp 887–899
DOI: 10.1021/acsbiomaterials.8b01112

Surface-Potential-Controlled Cell Proliferation and Collagen Mineralization on Electrospun Polyvinylidene Fluoride (PVDF) Fiber Scaffolds for Bone Regeneration
ACS Biomater. Sci. Eng., 2019, 5 (2), pp 582–593
DOI: 10.1021/acsbiomaterials.8b01108

In Vivo Evaluation of Engineered Self-Assembling Silk Fibroin Hydrogels after Intracerebral Injection in a Rat Stroke Model
Open Access Through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2019, 5 (2), pp 859–869
DOI: 10.1021/acsbiomaterials.8b01024

Cancellous-Bone-like Porous Iron Scaffold Coated with Strontium Incorporated Octacalcium Phosphate Nanowhiskers for Bone Regeneration
ACS Biomater. Sci. Eng., 2019, 5 (2), pp 509–518
DOI: 10.1021/acsbiomaterials.8b01188


ACS Catalysis

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Synthesis of α-Fluoro-α-amino Acid Derivatives via Photoredox-Catalyzed Carbofluorination
ACS Catal., 2019, 9 (2), pp 1558–1563
DOI: 10.1021/acscatal.8b04284

Effective Use of Renewable Electricity for Making Renewable Fuels and Chemicals
ACS Catal., 2019, 9 (2), pp 946–950
DOI: 10.1021/acscatal.8b04143

What Is Measured When Measuring Acidity in Zeolites with Probe Molecules?
Open Access Through ACS AuthorChoice
ACS Catal., 2019, 9 (2), pp 1539–1548
DOI: 10.1021/acscatal.8b04317

Carbonyl–Olefin Metathesis Catalyzed by Molecular Iodine
ACS Catal., 2019, 9 (2), pp 912–919
DOI: 10.1021/acscatal.8b03769

Visible-Light-Mediated Regioselective Chlorosulfonylation of Alkenes and Alkynes: Introducing the Cu(II) Complex [Cu(dap)Cl2] to Photochemical ATRA Reactions
ACS Catal., 2019, 9 (2), pp 1103–1109
DOI: 10.1021/acscatal.8b04188


ACS Chemical Biology

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Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI
ACS Chem. Biol., 2019, 14 (2), pp 164–169
DOI: 10.1021/acschembio.8b00969

Biosynthesis and Chemical Applications of Thioamides
ACS Chem. Biol., 2019, 14 (2), pp 142–163
DOI: 10.1021/acschembio.8b01022

Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10–2474
ACS Chem. Biol., 2019, 14 (2), pp 192–197
DOI: 10.1021/acschembio.8b01097

Transient Compound Treatment Induces a Multigenerational Reduction of Oxysterol-Binding Protein (OSBP) Levels and Prophylactic Antiviral Activity
Open Access Through ACS Editors’ Choice
ACS Chem. Biol., 2019, 14 (2), pp 276–287
DOI: 10.1021/acschembio.8b00984

Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1
ACS Chem. Biol., 2019, 14 (2), pp 223–235
DOI: 10.1021/acschembio.8b00807


ACS Chemical Neuroscience

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Alpha-Synuclein in Peripheral Tissues in Parkinson’s Disease
This article is part of the Alzheimer’s Disease and Parkinson’s Disease: Process and Progress special issue.
ACS Chem. Neurosci., 2019, 10 (2), pp 812–823
DOI: 10.1021/acschemneuro.8b00383

Exosomes in Parkinson’s Disease: Current Perspectives and Future Challenges
This article is part of the Alzheimer’s Disease and Parkinson’s Disease: Process and Progress special issue.
ACS Chem. Neurosci., 2019, 10 (2), pp 964–972
DOI: 10.1021/acschemneuro.8b00469

Genetic Analyses of Alzheimer’s Disease in China: Achievements and Perspectives
This article is part of the Alzheimer’s Disease and Parkinson’s Disease: Process and Progress special issue.
ACS Chem. Neurosci., 2019, 10 (2), pp 890–901
DOI: 10.1021/acschemneuro.8b00435

Targeting Neuroinflammation as a Therapeutic Strategy for Alzheimer’s Disease: Mechanisms, Drug Candidates, and New Opportunities
This article is part of the Alzheimer’s Disease and Parkinson’s Disease: Process and Progress special issue.
ACS Chem. Neurosci., 2019, 10 (2), pp 872–879
DOI: 10.1021/acschemneuro.8b00402

Balancing Apoptosis and Autophagy for Parkinson’s Disease Therapy: Targeting BCL-2
This article is part of the Alzheimer’s Disease and Parkinson’s Disease: Process and Progress special issue.
ACS Chem. Neurosci., 2019, 10 (2), pp 792–802
DOI: 10.1021/acschemneuro.8b00356


ACS Infectious Diseases

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Drug Discovery for Kinetoplastid Diseases: Future Directions
ACS Infect. Dis., 2019, 5 (2), pp 152–157
DOI: 10.1021/acsinfecdis.8b00298

Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis
ACS Infect. Dis., 2019, 5 (2), pp 272–280
DOI: 10.1021/acsinfecdis.8b00256

Pyrazolo[1,5-a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis
ACS Infect. Dis., 2019, 5 (2), pp 239–249
DOI: 10.1021/acsinfecdis.8b00225

Structural Basis for the Interaction and Processing of β-Lactam Antibiotics by l,d-Transpeptidase 3 (LdtMt3) from Mycobacterium tuberculosis
ACS Infect. Dis., 2019, 5 (2), pp 260–271
DOI: 10.1021/acsinfecdis.8b00244

The Fatty Acid Synthesis Protein Enoyl-ACP Reductase II (FabK) is a Target for Narrow-Spectrum Antibacterials for Clostridium difficile Infection
ACS Infect. Dis., 2019, 5 (2), pp 208–217
DOI: 10.1021/acsinfecdis.8b00205


ACS Medicinal Chemistry Letters

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Tissue Imaging by Mass Spectrometry: A Practical Guide for the Medicinal Chemist
ACS Med. Chem. Lett., 2019, 10 (2), pp 161–167
DOI: 10.1021/acsmedchemlett.8b00480

Evolution of Small Molecule Kinase Drugs
ACS Med. Chem. Lett., 2019, 10 (2), pp 153–160
DOI: 10.1021/acsmedchemlett.8b00445

Cytosine-Based TET Enzyme Inhibitors
ACS Med. Chem. Lett., 2019, 10 (2), pp 180–185
DOI: 10.1021/acsmedchemlett.8b00474

TRPV1 Modulators for the Treatment of Pain and Inflammation
ACS Med. Chem. Lett., 2019, 10 (2), pp 143–144
DOI: 10.1021/acsmedchemlett.8b00618

Imidazoquinolines as Novel Inhibitors of LRRK2 Kinase Activity
ACS Med. Chem. Lett., 2019, 10 (2), pp 148–149
DOI: 10.1021/acsmedchemlett.8b00654


ACS Synthetic Biology

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Riboswitch Signal Amplification by Controlling Plasmid Copy Number
Open Access Through ACS AuthorChoice
ACS Synth. Biol., 2019, 8 (2), pp 245–250
DOI: 10.1021/acssynbio.8b00454

Redirecting Metabolic Flux via Combinatorial Multiplex CRISPRi-Mediated Repression for Isopentenol Production in Escherichia coli
ACS Synth. Biol., 2019, 8 (2), pp 391–402
DOI: 10.1021/acssynbio.8b00429

Engineering a New Class of Anti-LacI Transcription Factors with Alternate DNA Recognition
Open Access Through ACS Editors’ Choice
ACS Synth. Biol., 2019, 8 (2), pp 307–317
DOI: 10.1021/acssynbio.8b00324

A Simple, Robust, and Low-Cost Method To Produce the PURE Cell-Free System
ACS Synth. Biol., 2019, 8 (2), pp 455–462
DOI: 10.1021/acssynbio.8b00427

Pyruvate Carboxylase Variants Enabling Improved Lysine Production from Glucose Identified by Biosensor-Based High-Throughput Fluorescence-Activated Cell Sorting Screening
ACS Synth. Biol., 2019, 8 (2), pp 274–281
DOI: 10.1021/acssynbio.8b00510


Biochemistry

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Evolving Rules for Protein Degradation? Insights from the Zinc Finger Degrome
Biochemistry, 2019, 58 (7), pp 861–864
DOI: 10.1021/acs.biochem.8b01307

Shaping the Future of Protein Engineering
Biochemistry, 2019, 58 (8), pp 1019–1021
DOI: 10.1021/acs.biochem.8b01322

In Which the Deity Attempts To Make a Ribose-Free Ribosome
Biochemistry, 2019, 58 (6), pp 431–432
DOI: 10.1021/acs.biochem.8b01191

Special Issue on Regulating the Central Dogma
This article is part of the Regulating the Central Dogma special issue.
Biochemistry, 2019, 58 (5), pp 295–296
DOI: 10.1021/acs.biochem.9b00059

An Open-Source Plate Reader
Biochemistry, 2019, 58 (6), pp 468–473
DOI: 10.1021/acs.biochem.8b00952


Bioconjugate Chemistry

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Delivery of Proteins and Nucleic Acids: Achievements and Challenges
This article is part of the Delivery of Proteins and Nucleic Acids: Achievements and Challenges special issue.
Bioconjugate Chem., 2019, 30 (2), pp 261–262
DOI: 10.1021/acs.bioconjchem.9b00096

Overcoming Endosomal Entrapment in Drug Delivery
This article is part of the Delivery of Proteins and Nucleic Acids: Achievements and Challenges special issue.
Bioconjugate Chem., 2019, 30 (2), pp 273–283
DOI: 10.1021/acs.bioconjchem.8b00778

The Endosomal Escape of Nanoparticles: Toward More Efficient Cellular Delivery
This article is part of the Delivery of Proteins and Nucleic Acids: Achievements and Challenges special issue.
Bioconjugate Chem., 2019, 30 (2), pp 263–272
DOI: 10.1021/acs.bioconjchem.8b00732

Bioconjugated Oligonucleotides: Recent Developments and Therapeutic Applications
This article is part of the Delivery of Proteins and Nucleic Acids: Achievements and Challenges special issue.
Bioconjugate Chem., 2019, 30 (2), pp 366–383
DOI: 10.1021/acs.bioconjchem.8b00761

Recent Advances in Anti-cancer Protein/Peptide Delivery
Bioconjugate Chem., 2019, 30 (2), pp 305–324
DOI: 10.1021/acs.bioconjchem.8b00750


Biomacromolecules

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Synthetic Extracellular Matrices with Nonlinear Elasticity Regulate Cellular Organization
Open Access Through ACS AuthorChoice
Biomacromolecules, 2019, 20 (2), pp 826–834
DOI: 10.1021/acs.biomac.8b01445

Rational Design of Multifunctional Renewable-Resourced Materials
This article is part of the The Rational Design of Multifunctional Renewable-Resourced Materials special issue.
Biomacromolecules, 2019, 20 (2), pp 569–572
DOI: 10.1021/acs.biomac.9b00060

Injectable, Self-Healing, and Multi-Responsive Hydrogels via Dynamic Covalent Bond Formation between Benzoxaborole and Hydroxyl Groups
Biomacromolecules, 2019, 20 (2), pp 1028–1035
DOI: 10.1021/acs.biomac.8b01652

Current State and New Trends in the Use of Cellulose Nanomaterials for Wastewater Treatment
This article is part of the The Rational Design of Multifunctional Renewable-Resourced Materials special issue.
Biomacromolecules, 2019, 20 (2), pp 573–597
DOI: 10.1021/acs.biomac.8b00839

Sustainable Chitin Nanofibrils Provide Outstanding Flame-Retardant Nanopapers
Biomacromolecules, 2019, 20 (2), pp 1098–1108
DOI: 10.1021/acs.biomac.8b01766


Journal of Agricultural and Food Chemistry

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From Flavanols Biosynthesis to Wine Tannins: What Place for Grape Seeds?
J. Agric. Food Chem., 2019, 67 (5), pp 1325–1343
DOI: 10.1021/acs.jafc.8b05768

Some New Findings Regarding the Antiadhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Bacteria
Open Access Through ACS Editors’ Choice
J. Agric. Food Chem., 2019, 67 (8), pp 2166–2174
DOI: 10.1021/acs.jafc.8b05625

Anthocyanins: From Sources and Bioavailability to Cardiovascular-Health Benefits and Molecular Mechanisms of Action
J. Agric. Food Chem., 2019, 67 (7), pp 1771–1783
DOI: 10.1021/acs.jafc.8b06737

Strategies for Accurate Quantitation of Volatiles from Foods and Plant-Origin Materials: A Challenging Task
J. Agric. Food Chem., 2019, 67 (6), pp 1619–1630
DOI: 10.1021/acs.jafc.8b06601

Discovery of Pimprinine Alkaloids as Novel Agents against a Plant Virus
J. Agric. Food Chem., 2019, 67 (7), pp 1795–1806
DOI: 10.1021/acs.jafc.8b06175


Journal of Chemical Theory and Computation

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OpenPathSampling: A Python Framework for Path Sampling Simulations. 1. Basics
Open Access Through ACS AuthorChoice
J. Chem. Theory Comput., 2019, 15 (2), pp 813–836
DOI: 10.1021/acs.jctc.8b00626

Open-Source, Python-Based Redevelopment of the ChemShell Multiscale QM/MM Environment
Open Access Through ACS AuthorChoice
J. Chem. Theory Comput., 2019, 15 (2), pp 1317–1328
DOI: 10.1021/acs.jctc.8b01036

OpenPathSampling: A Python Framework for Path Sampling Simulations. 2. Building and Customizing Path Ensembles and Sample Schemes
Open Access Through ACS AuthorChoice
J. Chem. Theory Comput., 2019, 15 (2), pp 837–856
DOI: 10.1021/acs.jctc.8b00627

Multiconfigurational Self-Consistent Field Theory with Density Matrix Embedding: The Localized Active Space Self-Consistent Field Method
J. Chem. Theory Comput., 2019, 15 (2), pp 972–986
DOI: 10.1021/acs.jctc.8b01009

Fast and Accurate Uncertainty Estimation in Chemical Machine Learning
J. Chem. Theory Comput., 2019, 15 (2), pp 906–915
DOI: 10.1021/acs.jctc.8b00959


Journal of Medicinal Chemistry

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Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors
Open Access Through ACS Editors’ Choice
J. Med. Chem., 2019, 62 (4), pp 1781–1792
DOI: 10.1021/acs.jmedchem.8b01725

Retraction of “CNS Physicochemical Property Space Shaped by a Diverse Set of Molecules with Experimentally Determined Exposure in the Mouse Brain”
J. Med. Chem., 2019, 62 (3), pp 1699–1699
DOI: 10.1021/acs.jmedchem.8b01388

Structure-Based Design of Inhibitors Selective for Human Proteasome β2c or β2i Subunits
J. Med. Chem., 2019, 62 (3), pp 1626–1642
DOI: 10.1021/acs.jmedchem.8b01884

Cubanes in Medicinal Chemistry
J. Med. Chem., 2019, 62 (3), pp 1078–1095
DOI: 10.1021/acs.jmedchem.8b00888

6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors
Open Access Through ACS Editors’ Choice
J. Med. Chem., 2019, 62 (4), pp 1793–1802
DOI: 10.1021/acs.jmedchem.8b01726


Journal of Natural Products

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Bioactive Diterpenoids from the Stems of Euphorbia royleana
J. Nat. Prod., 2019, 82 (2), pp 183–193
DOI: 10.1021/acs.jnatprod.8b00493

LC-HRMS-Database Screening Metrics for Rapid Prioritization of Samples to Accelerate the Discovery of Structurally New Natural Products
J. Nat. Prod., 2019, 82 (2), pp 211–220
DOI: 10.1021/acs.jnatprod.8b00575

Acidiphilamides A–E, Modified Peptides as Autophagy Inhibitors from an Acidophilic Actinobacterium, Streptacidiphilus rugosus
J. Nat. Prod., 2019, 82 (2), pp 341–348
DOI: 10.1021/acs.jnatprod.8b00828

Synthesis and Structure Reassignment of Malylglutamate, a Recently Discovered Earthworm Metabolite
J. Nat. Prod., 2019, 82 (2), pp 417–421
DOI: 10.1021/acs.jnatprod.8b01083

Lignan Dimers from Forsythia viridissima Roots and Their Antiviral Effects
J. Nat. Prod., 2019, 82 (2), pp 232–238
DOI: 10.1021/acs.jnatprod.8b00590


The Journal of Physical Chemistry B

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Internal Coordinate Normal Mode Analysis: A Strategy To Predict Protein Conformational Transitions
J. Phys. Chem. B, 2019, 123 (6), pp 1294–1301
DOI: 10.1021/acs.jpcb.8b11913

Integrated NMR, Fluorescence, and Molecular Dynamics Benchmark Study of Protein Mechanics and Hydrodynamics
Open Access Through ACS AuthorChoice
J. Phys. Chem. B, 2019, 123 (7), pp 1453–1480
DOI: 10.1021/acs.jpcb.8b08903

Unfolding Dynamics of Ubiquitin from Constant Force MD Simulation: Entropy–Enthalpy Interplay Shapes the Free-Energy Landscape
J. Phys. Chem. B, 2019, 123 (6), pp 1228–1236
DOI: 10.1021/acs.jpcb.8b09318

Resolving the Morphology of Peptoid Vesicles at the 1 nm Length Scale Using Cryogenic Electron Microscopy
Open Access Through ACS Editors’ Choice
J. Phys. Chem. B, 2019, 123 (5), pp 1195–1205
DOI: 10.1021/acs.jpcb.8b11752

Toward Ab Initio Protein Folding: Inherent Secondary Structure Propensity of Short Peptides from the Bioinformatics and Quantum-Chemical Perspective
J. Phys. Chem. B, 2019, 123 (6), pp 1215–1227
DOI: 10.1021/acs.jpcb.8b09245


The Journal of Physical Chemistry Letters

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Photocatalytic and Photoelectrochemical Degradation of Organic Compounds with All-Inorganic Metal Halide Perovskite Quantum Dots
Open Access Through ACS Editors’ Choice
J. Phys. Chem. Lett., 2019, 10 (3), pp 630–636
DOI: 10.1021/acs.jpclett.8b03849

Chinese Spring Festival Editorial
J. Phys. Chem. Lett., 2019, 10 (3), pp 701–701
DOI: 10.1021/acs.jpclett.9b00263

Highly Efficient Ultralong Organic Phosphorescence through Intramolecular-Space Heavy-Atom Effect
J. Phys. Chem. Lett., 2019, 10 (3), pp 595–600
DOI: 10.1021/acs.jpclett.8b03712

Nonsymmetrical Connection of Two Identical Building Blocks: Constructing Donor–Acceptor Molecules as Deep Blue Emitting Materials for Efficient Organic Emitting Diodes
J. Phys. Chem. Lett., 2019, 10 (4), pp 842–847
DOI: 10.1021/acs.jpclett.9b00300

Less Is More: Dilution Enhances Optical and Electrical Performance of a TADF Exciplex
J. Phys. Chem. Lett., 2019, 10 (4), pp 793–798
DOI: 10.1021/acs.jpclett.8b03646


Journal of Proteome Research

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Special Issue on Software Tools and Resources: Acknowledging the Toolmakers of Science
J. Proteome Res., 2019, 18 (2), pp 575–575
DOI: 10.1021/acs.jproteome.9b00022

PaDuA: A Python Library for High-Throughput (Phospho)proteomics Data Analysis
Open Access Through ACS AuthorChoice
J. Proteome Res., 2019, 18 (2), pp 576–584
DOI: 10.1021/acs.jproteome.8b00576

Cytoscape StringApp: Network Analysis and Visualization of Proteomics Data
This article is part of the Software Tools and Resources 2019 special issue.
J. Proteome Res., 2019, 18 (2), pp 623–632
DOI: 10.1021/acs.jproteome.8b00702

DeltaMass: Automated Detection and Visualization of Mass Shifts in Proteomic Open-Search Results
This article is part of the Software Tools and Resources 2019 special issue.
J. Proteome Res., 2019, 18 (2), pp 715–720
DOI: 10.1021/acs.jproteome.8b00728

Cross-ID: Analysis and Visualization of Complex XL–MS-Driven Protein Interaction Networks
Open Access Through ACS AuthorChoice
J. Proteome Res., 2019, 18 (2), pp 642–651
DOI: 10.1021/acs.jproteome.8b00725


Molecular Pharmaceutics

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Transferrin Receptor-Mediated Uptake at the Blood–Brain Barrier Is Not Impaired by Alzheimer’s Disease Neuropathology
Mol. Pharmaceutics, 2019, 16 (2), pp 583–594
DOI: 10.1021/acs.molpharmaceut.8b00870

Quantification of Proteins Involved in Drug Metabolism and Disposition in the Human Liver Using Label-Free Global Proteomics
Mol. Pharmaceutics, 2019, 16 (2), pp 632–647
DOI: 10.1021/acs.molpharmaceut.8b00941

Nanoparticle Properties for Delivery to Cartilage: The Implications of Disease State, Synovial Fluid, and Off-Target Uptake
Mol. Pharmaceutics, 2019, 16 (2), pp 469–479
DOI: 10.1021/acs.molpharmaceut.7b00484

Effect of Polymer Hydrophobicity on the Stability of Amorphous Solid Dispersions and Supersaturated Solutions of a Hydrophobic Pharmaceutical
Mol. Pharmaceutics, 2019, 16 (2), pp 682–688
DOI: 10.1021/acs.molpharmaceut.8b00972

Quantitative Imaging of the Hypoxia-Related Marker CAIX in Head and Neck Squamous Cell Carcinoma Xenograft Models
Open Access Through ACS AuthorChoice
Mol. Pharmaceutics, 2019, 16 (2), pp 701–708
DOI: 10.1021/acs.molpharmaceut.8b00950