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What’s the Most Important Unsolved Problem in Chemistry?

What’s the most important unsolved problem in chemistry? It’s a deceptively simple question. You could ask 100 different chemists and get 100 different answers. Chemistry is the central science, with ties to every other scientific discipline. It’s only natural that someone studying physical chemistry would have a very different selection for the most important unsolved problems in chemistry than a biochemistry researcher.

But just because there isn’t a single correct answer doesn’t mean the question isn’t worth asking. Debates like this about unsolved problems in chemistry help us have larger conversations about the nature of progress, the value of knowledge, and the challenges faced by humanity. Plus, talking about unsolved problems in chemistry can be a lot of fun.

Watch ACS Editors Discuss Their Picks for the Most Important Unsolved Problem in Chemistry

The ACS Publications Editors featured in the video are (in order of appearance): Professor Jillian M. Buriak, Editor-in-Chief of Chemistry of Materials; Professor Paul S. Weiss, Editor-in-Chief of ACS Nano; Professor Cynthia J. Burrows Editor-in-Chief of Accounts of Chemical Research, Professor Prashant V. Kamat, Editor-in-Chief of ACS Energy Letters; Professor Luis Liz-Marzán, Associate of ACS Nano, and Professor Kai Rossen Editor-in-Chief of Organic Process Research & Development.

Share Your Pick for the Most Important Unsolved Problem in Chemistry in the Comments

Meet ACS Publications’ Newest Associate Editors: Q4 2019

When a scientific journal adds a new associate editor, that change means more for readers than just a tweak to the masthead. New associate editors bring new experiences, new perspectives, and new ideas to their publications. Get to know some of ACS’ latest editors and learn what unique gifts they’ll be bringing to their respective journals.


Jingwen Chen, ACS Sustainable Chemistry & Engineering

What is your research focus? What initially attracted you to your field?

Computational toxicology technology for sustainable chemical management. I have been studying in this field since I was a postgraduate.

What do you hope to bring to your journal?

To promote manuscripts in the areas relating to the sustainable management of synthetic chemicals.

What are the major challenges facing your field today?

Mechanism understanding, modeling, and big-data analysis.

What do you think is the most interesting and/or important unsolved problem in your field?

Prediction of chemicals risks from their molecular structures.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Development of Prediction Models on Base-Catalyzed Hydrolysis Kinetics of Phthalate Esters with Density Functional Theory Calculation, Environ. Sci. Technol., 2019, 53, 5828−5837

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Margaret Faul, Organic Letters

What is your research focus? What initially attracted you to your field?

I trained as a synthetic organic chemist with Professor David A. Evans at Harvard University. At Amgen, I work in the Process Development organization whose mission is to transform the molecules of today into the medicines of tomorrow. My primary area of research is focused on the development of new modalities (synthetic and biologic) across all stages of development from preclinical to commercial. I became attracted to the field due to my desire to develop new medicines to treat patients and due to the excitement that the role brings. Every molecule is different, requiring new technical challenges and opportunities that need to be addressed which makes every day on the job fun!

What do you hope to bring to your journal?

I hope to attract high-quality industrial (and academic) synthetic manuscripts to Organic Letters that do not have a home elsewhere. This includes the excellent synthetic work that is being done across the Pharmaceutical industry for the identification and development of new chemical entities.

What are the major challenges facing your field today?

Two major challenges in the Pharmaceutical industry today are (1) the increasing complexity of our drugs which requires us to develop a new and innovative way to manufacture our products that are also efficient from a cost perspective; (2) There are many new medicines in development in our industry. The urgency to bring them forward for requires us to improve upon the typical length of time required to go from the identification of a clinical candidate to product launch, which can be 7-10 years. To be successful, we need to become more nimble in our development and reduce the overall time it takes to deliver our medicines to patients.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Molecular Complexity as a Driver for Chemical Process Innovation in the Pharmaceutical Industry
J. Org. Chem. 2019, 84, 8, 4583-4603
DOI: 10.1021/acs.joc.9b00735
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Gender Diversity in Process Chemistry
Org. Process Res. Dev. 2019, 23, 2, 109-113
DOI: 10.1021/acs.oprd.8b00378

Anything else you’d like readers to know about you?

I am Vice Chair of the International Consortium for Innovation and Quality in the Pharmaceutical Industry (IQ), a member of the Board of Directors of Organic Synthesis and on the Editorial Board of Science of Synthesis where with Thieme we sponsor the Dr. Margaret Faul Award for Women in chemistry.

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Bradley Moore, Organic Letters

What is your research focus? What initially attracted you to your field?

My research focuses on natural product discovery, biosynthesis, and biocatalysis. I have long been interested in the chemistry of life, how organisms construct elaborate molecules, and how we can apply the wisdom of evolution to solve challenging chemical problems.

What do you hope to bring to your journal?

I hope that my basic and applied background in connecting genes to organic chemistry will help attract and nurture new articles to Organic Letters focused on nature’s chemistry and biocatalysts.

What are the major challenges facing your field today?

Modern genomics is rapidly helping us understand the chemical logic of nature. The next major challenge will be to broadly apply that knowledge to biosynthesize chemicals at the industrial scale and to reduce our dependence on petrochemical feedstocks.

What do you think is the most interesting and/or important unsolved problem in your field?

One important unsolved problem that I find fascinating centers on unraveling how marine microorganisms synthesize massive polyether ladder toxins such as brevetoxin, one of nature’s most complex organic molecules that continues to plague our coastlines, impact our health and economy, and fascinate us as chemists. Biosynthesis may hold the key to improving our ability to predict how and when this toxin is made and perhaps one day may help mitigate its toxic impact.

Do you have a recent paper in an ACS journal that you’d like to highlight?

We published a natural product total synthesis paper in JACS late last year on napyradiomycins A1 and B1 in which we only employed biocatalysts to assemble these fascinating meroterpenoid antibiotics, thereby demonstrating the power of enzymes in the rapid construction of complex molecules.

Total Enzyme Syntheses of Napyradiomycins A1 and B1
J. Am. Chem. Soc. 2018, 140, 51, 17840-17845
DOI: 10.1021/jacs.8b10134

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Mariola Tortosa, Organic Letters

What is your research focus? What initially attracted you to your field?

Our goal is to develop novel chemical transformations using catalysis as a tool. Natural products and drugs are the inspiration behind many of the things we do. For this reason, asymmetric catalysis plays a key role in our research. We have an active program focused on the development of metal-catalyzed borylation reactions and on finding new catalytic ways to cleave carbon-nitrogen bonds. Broadly speaking, we want to discover robust catalytic methods that can provide answers to unsolved problems found in the synthesis of biologically active compounds.

What do you hope to bring to your journal?

Organic Letters is the leading organic chemistry journal. I see my role as an opportunity to help to define what is timely and significant to advance the field while maintaining its rapid publication times.

What are the major challenges facing your field today?

The development of catalytic transformations utilizing functional groups that are thought to be inert is an ongoing challenge. Progress in this field is changing the way scientists think about designing new molecules. More selective catalysts, as well as a deeper mechanistic understanding of chemical reactions, will have a profound impact on the design of new molecular entities, and in the late-stage functionalization of highly derivatized compounds.

Anything else you’d like readers to know about you?

I have two daughters, ages 7 and 3. Outside my workday, I find myself often running from swimming and tennis classes to piano lessons or choir rehearsals. We are a multicultural household, so we spend our vacation between the Mediterranean and Connecticut, visiting my husband’s family. We are lucky we can enjoy the best of both cultures!

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Christopher Cummins, Inorganic Chemistry

What is your research focus? What initially attracted you to your field?

My research is in the area of exploratory synthetic chemistry. I was attracted by the opportunity to bring new substances into existence, and then to be able to explore reactivity patterns and possible applications. Especially interesting to me are molecules that challenge our ideas about what is possible in terms of chemical structure and bonding.

What do you hope to bring to your journal?

I have experience working with chemical problems across the periodic table including organometallics and main-group element chemistry, and even uranium chemistry. I have a background as well in applying tools from quantum chemistry to problems in chemical structure, bonding, and reaction mechanisms. I hope to be able to elicit thoughtful and constructive reviews for my authors and to provide quick turnaround times.

What are the major challenges facing your field today?

A major challenge is the paucity of funds to support basic science. Inorganic chemistry is a very broad discipline and many pockets of the periodic table are much less well developed than others in terms of fundamental chemistry.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Functionalization of Intact Trimetaphosphate: A Triphosphorylating Reagent for C, N, and O Nucleophiles
J. Am. Chem. Soc., American Chemical Society, 2019, 141, 1852-1856
DOI: 10.1021/jacs.8b12204

Anything else you’d like readers to know about you?

Those interested can follow my lab on Twitter: @ccclabmit.

Microtubule Protein Level Predicts Drugs’ Effectiveness Against Brain Cancer Cells

Certain chemotherapy drugs, including paclitaxel (Taxol), block cancer cell division by targeting microtubules—structural polymers that are critical for cell division and other functions. Such microtubule-targeting agents (MTAs) are promising drug candidates against glioblastoma, an aggressive brain cancer, but they have not reached the clinic in part because of highly variable results in the lab. Now, researchers have found one reason why MTAs do not stop the growth of all glioblastoma cells: different levels of microtubule proteins in these cells affect their susceptibility to MTAs.

Microtubules contain polymerized tubulin dimers made of an α-tubulin and a β-tubulin, each of which comes in several forms. Although researchers know that MTAs bind to tubulins to disrupt microtubule function, not much is known about how a cell’s tubulin profile might impact the drugs’ effectiveness. So Lenka Munoz of the University of Sydney and her team analyzed 15 glioblastoma cell lines and characterized the amounts of tubulin proteins using immunoassays. Then they tested four small MTAs that can potentially cross the blood-brain barrier—colchicine, nocodazole, tivantinib, and CMPD1—against the cell lines. In all cases, cells with higher α- and β-tubulin levels were more susceptible to MTAs—including the 12 lines of stem-cell-like glioblastoma cells that the team tested. In the battle against the notoriously aggressive cancer, these cells are of particular interest because they can escape chemotherapy and cause a recurrence of the cancer.

To validate their finding, the researchers also tested three MTAs commonly used in the clinic: paclitaxel, vinblastine, and ixabepilone. In four key stem-cell-like cell lines that survived these drugs, tubulin levels were as much as 20% lower than lines that were effectively killed by MTAs, the researchers found. Why cells have different levels of tubulin is not known, Munoz says.

In addition, the researchers observed that cells with low tubulin levels and high MTA tolerance had more physical and molecular features typically found in nonproliferating, dormant cancer cells. This suggests to the researchers that low-tubulin-containing cells somehow convert to a dormant state during which they do not divide. That way, the cells survive MTA treatment and can proliferate once the MTA therapy is finished.

The team is working to understand the molecular mechanisms behind this switch to dormancy, information that researchers could use to design drugs to prevent cancer cells from going into that state, Munoz says. She says physicians could then use such drugs along with MTAs to eradicate all cells within a brain tumor.

Maria G. Castro, a brain cancer scientist at the University of Michigan Medical School who does both basic and translational research, calls the data from this study “exciting” and says that this work paves the way for personalized therapy when using MTAs to treat brain cancer. The next critical steps would be to test the findings in animal models using cells with different MTA sensitivity, she says.

This article is reproduced with permission from C&EN (© American Chemical Society). The article was first published on September 10, 2019.

Get Research on Proteolytic Regulation of Cellular Physiology

<i>Dr. Luke Wiseman, Associate Professor, Department of Molecular Medicine, The Scripps Research Institute</i>

Dr. Luke Wiseman, Associate Professor, Department of Molecular Medicine, The Scripps Research Institute

This editorial by Dr. Luke Wiseman of The Scripps Research Institute accompanies the ACS Chemical Biology Special Issue on Proteolytic Regulation of Cellular Physiology.

Like a block of granite in the hands of a sculptor, cellular proteomes must undergo constant reshaping and remodeling to accomplish all of the intricate biochemical processes necessary for organismal survival. One of the primary molecular mechanisms responsible for this reshaping is mediated through the activity of proteases. Proteases primarily function through the catabolic processing of substrate proteins into smaller peptides and/or amino acids. Despite this common function, proteases can have wide-ranging effects on the cellular proteome. For example, quality control proteases utilize the power of ATP to promiscuously degrade damaged or misfolded proteins, preventing their potentially toxic intracellular accumulation. Alternatively, highly specific proteases such as the SUMO peptidases cleave at a specific peptide bond to allow selective regulation of specific biological functions. Thus, cellular proteases serve as both the chisel and the scalpel to sensitively remodel the proteome in response to the continually changing physiologic environment in all organisms, from bacteria to mammals.

The potential for proteases to influence proteomes through both promiscuous and specific activities has allowed evolution to integrate proteolytic activity into nearly every aspect of cellular physiology. Proteases are intricately involved in the regulation of all biological functions, including membrane remodeling, protection against pathologic insults, stress-responsive signaling, and apoptosis. Considering the central importance of proteases in regulating all these aspects of cellular physiology, it is not surprising that imbalances in protease activity are implicated in the onset and pathogenesis of etiologically diverse pathologic conditions including viral infection, cancer, and neurodegenerative disease. This has led to a significant effort to understand both the molecular mechanism by which proteases regulate cellular physiology and identify specific contributions of proteases in dictating organismal function in the context of both health and disease.  

As a field, chemical biology has been and continues to be at the forefront of defining the physiologic and pathologic importance of proteases in diverse organisms. Advances in chemical biology led to the development of new proteomic approaches to define the activity of both promiscuous and specific proteases, revealing critical new insights into protease function. Chemical biologists have also leveraged our understanding of proteolytic mechanisms to develop new ligand-regulated strategies to sensitively regulate protein stability post-translationally, transforming our ability to probe the activity of different proteins with temporal or dosable resolution. Furthermore, the establishment of chemical, biological approaches such as activity-based protein profiling has allowed us to probe the mechanism of protease regulation and activity both in vitro and in vivo. Finally, the development of compounds that modulate the activity of specific proteases or proteolytic mechanisms has provided new opportunities to define the translational potential for pharmacologically targeting protein degradation in etiologically diverse diseases. Suffice to say, chemical biology and protease biology have become intricately integrated over the years to form a mutually self-sustaining experimental enterprise.       

ACS Chemical Biology put together a Special Issue with a collection of articles highlighting the continued contributions of chemical biology in defining the importance of proteases in the regulation of cellular physiology in the context of health and disease. This includes both reviews and original articles describing recent technological advances, new experimental resources, and new discoveries in protease biology. Collectively, these articles provide a snapshot of the ongoing contributions chemical biologists are making in the field of protease biology. Furthermore, this issue serves to identify new challenges and opportunities for chemical biologists to continue to contribute to both our ever-growing understanding of protease regulation and the development of new pharmacologic approaches that target protease or proteolytic pathways for therapeutic intervention.

The ability to probe the N-termini of the cellular proteome through the application of N-terminal proteomics provides a broadly applicable experimental platform to identify new proteolytic activities and define substrate specificity for diverse proteases. In a review by Luo et al. included in this special issue, the methodology, biological potential, and future for these approaches are discussed, highlighting the central importance of N-terminal proteomics in protease biology. Underscoring this importance, an original article by Gordon et al. utilizes N-terminal proteomics to define the proteolytic remodeling associated with ulcerative colitis, revealing new insights into the contributions of host and microbial proteases in the dysregulated proteolysis associated with this disease. Since proteolytic processing results in the formation of both new N- and C-termini, following the formation of new C-termini within the proteome offers an alternative approach to follow proteolytic events in the context of health and disease.  

The conjugation and removal of small proteins such as SUMO through post-translational mechanisms have emerged as a critical determinant in dictating the biological activity of multiple cellular pathways. In a review included in this special issue, Jia et al. describe the contributions of SUMO specific proteases (SENPs) in regulating SUMOylation and its downstream functional outputs, specifically focusing on the importance of chemical biological tools and approaches in studying this class of specific proteases.

Some of the most significant contributions of chemical biology to the study of proteases have resulted from the development of compounds that target specific proteases. The development of these compounds has provided new opportunities to probe the specific contributions of proteases in complex biological systems and define the therapeutic potential for targeting different proteases in the context of health and disease. In this issue, we include articles applying different experimental approaches describing the establishment and/or implementation of inhibitors of both bacterial and mammalian proteases. Using a peptide substrate library, Babin et al. assess inhibitors of the E. coli AAA+ ATP-dependent protease Lon, identifying new substrates and compounds that can be employed to probe the activity of this important protease. Alternatively, using a more structure driven approach, Solania et al. describe the identification of selective cell-permeable inhibitors of caspase-3, establishing a new tool to probe the importance of this protease in cellular function. Furthermore, using a combination of activity-based protein profiling and proteomics, Griswold et al. demonstrate that catalytic activity of the serine peptidase DPP9 functions to inhibit the activity of the CARD8 inflammasome, revealing new insights into the regulation of cell death induced through this complex.  

Apart from the direct targeting of proteases, chemical biological approaches that ‘hijack’ proteolytic mechanisms have emerged as a promising therapeutic approach to post-translationally influence the stability of proteins in the context of diverse types of disease. One such strategy used heterobifunctional compounds, termed proteolysis targeted chimeric compounds (PROTACs), that bind to both a target protein and E3 ligases to promote the ubiquitination and subsequent degradation of a protein of interest. However, only a few E3 ligases have been liganded, limiting the available toolbox for PROTAC development. In this issue, Ward et al. describe the application of activity-based protein profiling to identify compounds that bind to the E3 ligase RNF4 and are suitable for targeted degradation applications. This demonstrates the potential for implementing activity-based protein profiling strategies to expand the toolbox available for targeted protein degradation applications.

Mitochondrial proteostasis and function are regulated by a network of proteases localized throughout the different mitochondrial environments defined by the double membrane architecture. In two reviews included in this issue, the importance of mitochondrial proteases in dictating different aspects of mitochondrial function is highlighted. In a comprehensive review by Sam et al., the involvement of mitochondrial proteases in regulating mitochondrial phospholipid synthesis is discussed, revealing critical links between proteolytic mechanisms and the composition of cellular membranes. Extending this, Batterbsy et al. describe the importance of mitochondrial proteases in linking mitochondrial translation to stress-responsive alterations in mitochondrial morphology and function, including discussion of the evolutionary relationship between mitochondrial ribosomal synthesis and regulation of mitochondria. These articles, together, begin to highlight the opportunity for chemical biology to contribute to defining the importance of mitochondrial proteases in regulating diverse functional aspects of this important organelle. 

One class of proteases that present a unique set of challenges is intramembrane proteases (IMPs), due to their localization within cellular membranes. However, despite this, IMPs represent a critical class of proteases involved in diverse biological functions. Beard et al. directly address these challenges in a review included in this issue, specifically emphasizing the contributions of chemical, biological tools, and approaches in deconvoluting the functional implications of IMPs in cellular regulation.

Ultimately, a goal of many chemical biologists studying proteases is to define new therapeutic opportunities to intervene in human diseases such as cancer through the pharmacologic targeting of specific proteases. Two articles included in this issue describe the importance of proteases in cancer, with a specific focus on how pharmacologic targeting of proteolytic mechanisms could influence disease progression. In a review by Boudreau et al., the importance of pro-caspase 3 in oncogenic transformation is discussed, highlighting the potential for activating this pro-apoptotic protease as a new approach to intervene in diverse types of cancer. Furthermore, Wong et al. describe the dependencies of many cancer cells on the mitochondrial AAA+ protease CLPP, indicating a new potential therapeutic opportunity to mitigate tumorigenesis through the pharmacologic targeting of CLPP.

While pharmacologic targeting of proteases and proteolytic pathways offers promise for therapeutic development, many challenges are associated with targeting these types of proteins for disease intervention. These include challenges in developing highly selective modulators of a specific protease and the difficulty in identifying specific proteases that can be modulated in diseased cells without significantly impacting healthy cells. In an original article by Henes et al., the authors describe other types of challenges associated with developing therapeutic protease inhibitors against HIV-1 protease. They show that the accumulation of mutations on sites distal from the protease active site can reduce the affinity of Darunavir for the HIV-1 protease and ultimately enhance drug resistance. This highlights important considerations for developing therapeutic strategies to target viral or bacterial proteases.

The scope and breadth of the articles included in this special issue highlight the wide-ranging impact of chemical biologists in the study of proteases. As we continue developing and implementing new approaches to probe protease biology, discoveries will continue to be made regarding this remarkable class of proteins and their impact on regulating cellular physiology across different organisms and different environments. Moreover, as we learn more about protease function and biology, we will identify new opportunities to therapeutically manipulate proteases to treat a host of diseases, with chemical biologists leading the way. 

Journals Discover the Most-Read Physical Chemistry Articles of October 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in October 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Get free monthly updates on the most-read research in your field.

Read more of October’s most-read articles.


ACS Applied Energy Materials

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Unlocking the Potential of Fluoride-Based Solid Electrolytes for Solid-State Lithium Batteries
DOI: 10.1021/acsaem.9b01166

An Efficient Synthetic Method to Prepare High-Performance Ni-rich LiNi0.8Co0.1Mn0.1O2 for Lithium-Ion Batteries
DOI: 10.1021/acsaem.9b01414

Realizing High Thermoelectric Performance in GeTe through Optimizing Ge Vacancies and Manipulating Ge Precipitates
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsaem.9b01585

Long-Lived Multilayer Coatings for Smart Windows: Integration of Energy-Saving, Antifogging, and Self-Healing Functions
DOI: 10.1021/acsaem.9b01382

Stabilizing Capacity Retention in NMC811/Graphite Full Cells via TMSPi Electrolyte Additives
DOI: 10.1021/acsaem.9b00727


ACS Earth and Space Chemistry

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Interstellar Formamide (NH2CHO), a Key Prebiotic Precursor
DOI: 10.1021/acsearthspacechem.9b00154

Complex Organic Molecules in Star-Forming Regions of the Magellanic Clouds
DOI: 10.1021/acsearthspacechem.9b00065

Formation of Secondary Organic Aerosol from the Heterogeneous Oxidation by Ozone of a Phytoplankton Culture
DOI: 10.1021/acsearthspacechem.9b00201

Characterization of Secondary Organic Aerosol Tracers over Tianjin, North China during Summer to Autumn
DOI: 10.1021/acsearthspacechem.9b00170

Chemical Characterization of Cloudwater Collected at Puy de Dôme by FT-ICR MS Reveals the Presence of SOA Components
DOI: 10.1021/acsearthspacechem.9b00153


ACS Energy Letters

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Organic Solar Cells: Recent Progress and Challenges
DOI: 10.1021/acsenergylett.9b02071

Three Pillars of Effective Research. Measurements, Analysis, and Dissemination – A Virtual Issue
DOI: 10.1021/acsenergylett.9b01946

Electronic Structure of the Plasmons in Metal Nanocrystals: Fundamental Limitations for the Energy Efficiency of Hot Electron Generation
DOI: 10.1021/acsenergylett.9b01617

Reversible Removal of Intermixed Shallow States by Light Soaking in Multication Mixed Halide Perovskite Films
Open Access through ACS AuthorChoice
DOI: 10.1021/acsenergylett.9b01726

Reversible Color Switching in Dual-Emitting Mn(II)-Doped CsPbBr3 Perovskite Nanorods: Dilution versus Evaporation
DOI: 10.1021/acsenergylett.9b01702


ACS Photonics

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Conditions for Enhancing Chiral Nanophotonics near Achiral Nanoparticles
DOI: 10.1021/acsphotonics.9b01200

High-Gyrotropy Seedlayer-Free Ce:TbIG for Monolithic Laser-Matched SOI Optical Isolators
DOI: 10.1021/acsphotonics.9b00707

Tuning Vibrational Strong Coupling with Co-Resonators
DOI: 10.1021/acsphotonics.9b01040

Tunable Light Emission by Electrically Excited Plasmonic Antenna
DOI: 10.1021/acsphotonics.9b00954

Correlative Dark-Field and Photoluminescence Spectroscopy of Individual Plasmon–Molecule Hybrid Nanostructures in a Strong Coupling Regime
DOI: 10.1021/acsphotonics.9b01079


Energy & Fuels

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Asphaltene and Maltene Adsorption into Graphene
DOI: 10.1021/acs.energyfuels.9b01681

A Review of Numerical Modeling and Experimental Analysis of Combustion in Moving Grate Biomass Combustors
DOI: 10.1021/acs.energyfuels.9b02073

Wetting of Mineral Surfaces by Fatty-Acid-Laden Oil and Brine: Carbonate Effect at Elevated Temperature
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.energyfuels.9b01351

Food and Market Waste–A Pathway to Sustainable Fuels and Waste Valorization
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.energyfuels.9b01650

Camphorane as a Renewable Diesel Blendstock Produced by Cyclodimerization of Myrcene
DOI: 10.1021/acs.energyfuels.9b02557


Industrial & Engineering Chemistry Research

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Announcing the 2019 Class of Influential Researchers
DOI: 10.1021/acs.iecr.9b05242

Synthesis and Physicochemical Characterization of Shaped Catalysts of β and Y Zeolites for Cyclization of Citronellal
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.iecr.9b02829

NASCRE-4 Editorial
DOI: 10.1021/acs.iecr.9b04913

110th Anniversary: Surrogate Models Based on Artificial Neural Networks To Simulate and Optimize Pressure Swing Adsorption Cycles for CO2 Capture
DOI: 10.1021/acs.iecr.9b02383

Boron Nitride Nanosheets from Different Preparations and Correlations with Their Material Properties
DOI: 10.1021/acs.iecr.9b03930


Journal of Chemical & Engineering Data

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Highlighting 10 Years of NIST Cooperation and Service to the Thermophysical Properties Data Community
DOI: 10.1021/acs.jced.9b00920

Experimental Study on the Hydrate Phase Equilibrium of Synthetic Natural Gas Containing H2S
DOI: 10.1021/acs.jced.9b00510

Solubility of Gastrodin in Pure and Mixed Solvents at 273.15–313.15 K and Its Correlation with Different Thermodynamic Models
DOI: 10.1021/acs.jced.9b00286

Solid–Liquid Phase Equilibria in the Ternary Systems NaCl–ZnCl2–H2O and CaCl2–ZnCl2–H2O at 323 K
DOI: 10.1021/acs.jced.9b00422

Lanthanum and Cerium Separation Using an Aqueous Two-Phase System with Ionic Liquid
DOI: 10.1021/acs.jced.9b00293


Journal of Chemical Information and Modeling

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TeachOpenCADD-KNIME: A Teaching Platform for Computer-Aided Drug Design Using KNIME Workflows
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.jcim.9b00662

Graph Convolutional Neural Networks for Predicting Drug-Target Interactions
DOI: 10.1021/acs.jcim.9b00628

A Quantum-Inspired Method for Three-Dimensional Ligand-Based Virtual Screening
DOI: 10.1021/acs.jcim.9b00195

Learning Drug Functions from Chemical Structures with Convolutional Neural Networks and Random Forests
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jcim.9b00236

Sharing Data from Molecular Simulations
DOI: 10.1021/acs.jcim.9b00665


Journal of Chemical Theory and Computation

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Pitfalls of the Martini Model
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00473

Self-Consistent Density-Functional Embedding: A Novel Approach for Density-Functional Approximations
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00063

Insights into Membrane Protein–Lipid Interactions from Free Energy Calculations
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00548

A Linear-Scaling Method for Noncovalent Interactions: An Efficient Combination of Absolutely Localized Molecular Orbitals and a Local Random Phase Approximation Approach
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00615

Accuracy of Spin-Component-Scaled CC2 Excitation Energies and Potential Energy Surfaces
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00676


The Journal of Physical Chemistry A

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Viewpoint on the 2019 International Conference on Photochemistry
DOI: 10.1021/acs.jpca.9b09156

Method for the Calculation of the Hamaker Constants of Organic Materials by the Lifshitz Macroscopic Approach with Density Functional Theory
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpca.9b06433

Hydrogen-Bonding Mediated Reactions of Criegee Intermediates in the Gas Phase: Competition between Bimolecular and Termolecular Reactions and the Catalytic Role of Water
DOI: 10.1021/acs.jpca.9b07117

International Year of the Periodic Table from a Physical Chemistry Perspective
DOI: 10.1021/acs.jpca.9b07024

Calculation of Free-Energy Barriers with TD-DFT: A Case Study on Excited-State Proton Transfer in Indigo
DOI: 10.1021/acs.jpca.9b05163


The Journal of Physical Chemistry B

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Proteins: “Boil ’Em, Mash ’Em, Stick ’Em in a Stew”
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.jpcb.9b05467

Physical Chemistry of Epigenetics: Single-Molecule Investigations
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.jpcb.9b06214

Insights into Proton-Transfer Pathways during Water Oxidation in Photosystem II
DOI: 10.1021/acs.jpcb.9b06244

Electrolytes Change the Interfacial Water Structure but Not the Vibrational Dynamics
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.9b08131

The Widom Line and the Lennard-Jones Potential
DOI: 10.1021/acs.jpcb.9b05426


The Journal of Physical Chemistry C

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Taking the Heat Off of Plasmonic Chemistry
DOI: 10.1021/acs.jpcc.9b08143

Surface Premelting and Interfacial Interactions of Semi-Clathrate Hydrate
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.9b06376

Electronic–Vibrational Coupling and Electron Transfer
DOI: 10.1021/acs.jpcc.9b03849

Surface-Specific Spectroscopy of Water at a Potentiostatically Controlled Supported Graphene Monolayer
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.9b05844

The Mechanism of Dedoping PEDOT:PSS by Aliphatic Polyamines
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.9b07718


The Journal of Physical Chemistry Letters

***

The Causes of Degradation of Perovskite Solar Cells
DOI: 10.1021/acs.jpclett.9b00613

Two Dimensions Are Better for Perovskites
DOI: 10.1021/acs.jpclett.9b01568

Phospholipid Scramblases Remodel the Shape of Asymmetric Membranes
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.9b02531

Journey of Making Cesium Lead Halide Perovskite Nanocrystals: What’s Next
DOI: 10.1021/acs.jpclett.9b02412

Outstanding Challenges of Zero-Dimensional Perovskite Materials
DOI: 10.1021/acs.jpclett.9b00175

Journals Discover the Most-Read Organic/Inorganic Chemistry Articles of October 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in October 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Get free monthly updates on the most-read research in your field.

Read more of October’s most-read articles.


ACS Catalysis

***

Recent Advances in Pyridinium Salts as Radical Reservoirs in Organic Synthesis
DOI: 10.1021/acscatal.9b03084

Catalysis of Organic Reactions through Halogen Bonding
DOI: 10.1021/acscatal.9b02894

Nickel/Cobalt-Catalyzed C(sp3)–C(sp3) Cross-Coupling of Alkyl Halides with Alkyl Tosylates
DOI: 10.1021/acscatal.9b03352

Gold-Catalyzed C–H Functionalization with Aryl Germanes
DOI: 10.1021/acscatal.9b02841

A General Route to Bicyclo[1.1.1]pentanes through Photoredox Catalysis
DOI: 10.1021/acscatal.9b03190


ACS Combinatorial Science

***

A Solution Phase Platform to Characterize Chemical Reaction Compatibility with DNA-Encoded Chemical Library Synthesis
DOI: 10.1021/acscombsci.9b00113

Visible-Light-Initiated One-Pot, Three-Component Synthesis of 2-Amino-4H-pyran-3,5-dicarbonitrile Derivatives
DOI: 10.1021/acscombsci.9b00124

Multicomponent Approach to Libraries of Substituted Dihydroorotic Acid Amides
DOI: 10.1021/acscombsci.9b00144

Enzyme Degassing for Oxygen-Sensitive Reactions in Open Vessels of an Automated Parallel Synthesizer: RAFT Polymerizations
DOI: 10.1021/acscombsci.9b00082

Scanning Electrochemical Flow Cell with Online Mass Spectroscopy for Accelerated Screening of Carbon Dioxide Reduction Electrocatalysts
DOI: 10.1021/acscombsci.9b00130


ACS Medicinal Chemistry Letters

***

PROTAC-Mediated Degradation of Estrogen Receptor in the Treatment of Cancer
DOI: 10.1021/acsmedchemlett.9b00397

Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates
Open Access through ACS AuthorChoice
DOI: 10.1021/acsmedchemlett.9b00301

“AβTau”, Lobby or Religion?
DOI: 10.1021/acsmedchemlett.9b00439

PROTAC Degradation of IRAK4 for the Treatment of Cancer
DOI: 10.1021/acsmedchemlett.9b00423

Peptide-Cleavable Self-immolative Maytansinoid Antibody–Drug Conjugates Designed To Provide Improved Bystander Killing
Open Access through ACS AuthorChoice
DOI: 10.1021/acsmedchemlett.9b00310


Bioconjugate Chemistry

***

Antibody–Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents
DOI: 10.1021/acs.bioconjchem.9b00306

Dual Site-Specific Labeling of an Antibody Fragment through Sortase A and π-Clamp Conjugation
DOI: 10.1021/acs.bioconjchem.9b00639

Targeted, Stimuli-Responsive, and Theranostic 19F Magnetic Resonance Imaging Probes
DOI: 10.1021/acs.bioconjchem.9b00582

Zwitterionic Modification of Nanomaterials for Improved Diagnosis of Cancer Cells
DOI: 10.1021/acs.bioconjchem.9b00543

Copper-64 Labeled PEGylated Exosomes for In Vivo Positron Emission Tomography and Enhanced Tumor Retention
DOI: 10.1021/acs.bioconjchem.9b00587


Inorganic Chemistry

***

The Chemistry Women Mentorship Network (ChemWMN): A Tool for Creating Critical Mass in Academic Chemistry
DOI: 10.1021/acs.inorgchem.9b02707

Metals in Biology: From Metallomics to Trafficking
DOI: 10.1021/acs.inorgchem.9b02965

Structure and Properties of a Five-Coordinate Nickel(II) Porphyrin
DOI: 10.1021/acs.inorgchem.9b00348

Inorganic Chemistry Approaches to Activity-Based Sensing: From Metal Sensors to Bioorthogonal Metal Chemistry
DOI: 10.1021/acs.inorgchem.9b01221

Spectroscopic X-ray and Mössbauer Characterization of M6 and M5 Iron(Molybdenum)-Carbonyl Carbide Clusters: High Carbide-Iron Covalency Enhances Local Iron Site Electron Density Despite Cluster Oxidation
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.inorgchem.9b01870


Journal of Medicinal Chemistry

***

Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor
DOI: 10.1021/acs.jmedchem.9b01234

Tyrosine Kinase 2 (TYK2) Allosteric Inhibitors To Treat Autoimmune Diseases
DOI: 10.1021/acs.jmedchem.9b01612

Antibiotic Adjuvants: Make Antibiotics Great Again!
DOI: 10.1021/acs.jmedchem.8b01781

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165
DOI: 10.1021/acs.jmedchem.9b00444

Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases
DOI: 10.1021/acs.jmedchem.9b00533


Journal of Natural Products

***

Nectriatide, a Potentiator of Amphotericin B Activity from Nectriaceae sp. BF-0114
DOI: 10.1021/acs.jnatprod.8b01056

Constituents from the Leaves of Tetraena mongolica and Their Protective Activity in HEK 293t Cells Damaged by CdCl2
DOI: 10.1021/acs.jnatprod.9b00212

Anti-Lymphangiogenic Alkaloids from the Zoanthid Zoanthus vietnamensis Collected in Taiwan
DOI: 10.1021/acs.jnatprod.9b00451

Basimarols A, B, and C, Highly Oxygenated Pimarane Diterpenoids from Basilicum polystachyon
DOI: 10.1021/acs.jnatprod.9b00522

Tripterfordins A–O, Dihydro-β-agarofuran Sesquiterpenoids from the Leaves of Tripterygium wilfordii
DOI: 10.1021/acs.jnatprod.9b00089


The Journal of Organic Chemistry

***

The Breadth and Depth of C–H Functionalization
DOI: 10.1021/acs.joc.9b02663

Axial Chirality at the Boron–Carbon Bond: Synthesis, Stereodynamic Analysis, and Atropisomeric Resolution of 6-Aryl-5,6-dihydrodibenzo[c,e][1,2]azaborinines
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.joc.9b01550

N-Amino-7-azaindole as the N,N′-Bidentate Directing Group: Ruthenium-Catalyzed Oxidative Annulation of N-(7-Azaindole)benzamides with Alkynes via C–H Bond Activation
DOI: 10.1021/acs.joc.9b01598

En Route to Intermolecular Cross-Dehydrogenative Coupling Reactions
DOI: 10.1021/acs.joc.9b01704

Development of an Imine Chaperone for Selective C–H Functionalization of Alcohols via Radical Relay
DOI: 10.1021/acs.joc.9b02052


Molecular Pharmaceutics

***

Use of Terahertz-Raman Spectroscopy to Determine Solubility of the Crystalline Active Pharmaceutical Ingredient in Polymeric Matrices during Hot Melt Extrusion
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00703

Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00406

Recent Advances in Understanding the Micro- and Nanoscale Phenomena of Amorphous Solid Dispersions
DOI: 10.1021/acs.molpharmaceut.9b00601

Scale-Independent Microfluidic Production of Cationic Liposomal Adjuvants and Development of Enhanced Lymphatic Targeting Strategies
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00730

From Target to Drug: Generative Modeling for the Multimodal Structure-Based Ligand Design
DOI: 10.1021/acs.molpharmaceut.9b00634


Organic Letters

***

Characterization of Leptazolines A–D, Polar Oxazolines from the Cyanobacterium Leptolyngbya sp., Reveals a Glitch with the “Willoughby–Hoye” Scripts for Calculating NMR Chemical Shifts
DOI: 10.1021/acs.orglett.9b03216

Nickel-Catalyzed Selective Reduction of Carboxylic Acids to Aldehydes
DOI: 10.1021/acs.orglett.9b02779

Direct and Chemoselective Synthesis of Tertiary Difluoroketones via Weinreb Amide Homologation with a CHF2-Carbene Equivalent
DOI: 10.1021/acs.orglett.9b03024

Intermolecular Phosphite-Mediated Radical Desulfurative Alkene Alkylation Using Thiols
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.orglett.9b03018

Visible-Light-Induced Copper-Catalyzed Intermolecular Markovnikov Hydroamination of Alkenes
DOI: 10.1021/acs.orglett.9b02863


Organic Process Research & Development

***

Some Items of Interest to Process R&D Chemists and Engineers
DOI: 10.1021/acs.oprd.9b00412

Explosion Hazards of Sodium Hydride in Dimethyl Sulfoxide, N,N-Dimethylformamide, and N,N-Dimethylacetamide
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.oprd.9b00276

The Role of Process Chemistry in Providing Healthy Food for a Healthy and Growing Planet
DOI: 10.1021/acs.oprd.9b00383

Applications of the 12 Principles of Green Chemistry in the Crop Protection Industry
DOI: 10.1021/acs.oprd.9b00305

Development of a Scalable Process for the Insecticidal Candidate Tyclopyrazoflor. Part 1. Evaluation of [3 + 2] Cyclization Strategies to 3-(3-Chloro-1H-pyrazol-1-yl)pyridine
DOI: 10.1021/acs.oprd.9b00127


Organometallics

***

Isolation and Characterization of a Homoleptic Tetramethylcobalt(III) Distorted Square-Planar Complex
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.organomet.9b00387

Asymmetric Synthesis Enabled by Organometallic Complexes
DOI: 10.1021/acs.organomet.9b00627

Synthesis, Structure, and Reactivity of an NHC Silyl Gold(I) Complex
DOI: 10.1021/acs.organomet.9b00574

Synthesis of (MeCN)2Pd(CF3)OTs, a General Precursor to Palladium(II) Trifluoromethyl Complexes LPd(CF3)X
DOI: 10.1021/acs.organomet.9b00516

Dioxo-, Oxo-imido-, and Bis-imido-Molybdenum(VI) Complexes with a Bis-phenolate-NHC Ligand
DOI: 10.1021/acs.organomet.9b00472

Journals Discover the Most-Read Multidisciplinary Chemistry Articles of October 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in October 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Get free monthly updates on the most-read research in your field.

Read more of October’s most-read articles.


Accounts of Chemical Research

***

Topologically Unique Molecular Nanocarbons
DOI: 10.1021/acs.accounts.9b00402

The Fundamentals Behind the Use of Flow Reactors in Electrochemistry
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.accounts.9b00412

Activity-Based Sensing and Theranostic Probes Based on Photoinduced Electron Transfer
DOI: 10.1021/acs.accounts.9b00340

Advanced Molecular Nanocarbons: Fertile Ground for Discovery, Creation, and Invention
DOI: 10.1021/acs.accounts.9b00501

Plasmon-Mediated Chemical Reactions on Nanostructures Unveiled by Surface-Enhanced Raman Spectroscopy
DOI: 10.1021/acs.accounts.9b00280


ACS Central Science

***

The Good Side of Carbon Monoxide
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.9b01015

From Wood to Tetrahydro-2-benzazepines in Three Waste-Free Steps: Modular Synthesis of Biologically Active Lignin-Derived Scaffolds
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.9b0078

Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable PhotoPROTACs
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.9b00713

Rapid Cycling and Exceptional Yield in a Metal-Organic Framework Water Harvester
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.9b00745

A Conversation with Tammy Hsu
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.9b01014


ACS Omega

***

Waste Toner-Derived Carbon/Fe3O4 Nanocomposite for High-Performance Supercapacitor
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsomega.9b01337

Aerosol Gas-Phase Components from Cannabis E-Cigarettes and Dabbing: Mechanistic Insight and Quantitative Risk Analysis
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsomega.9b02301

Reactivity Control of Polymer Functional Groups by Altering the Structure of Thermoresponsive Triblock Copolymers
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsomega.9b01816

Supramolecular Mimic for Bottlebrush Polymers in Bulk
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsomega.9b02126

Early Metal Di(pyridyl) Pyrrolide Complexes with Second Coordination Sphere Arene−π Interactions: Ligand Binding and Ethylene Polymerization
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsomega.9b01788


Chemical Reviews

***

Nanowires for Electrochemical Energy Storage
DOI: 10.1021/acs.chemrev.9b00326

Quantum Chemistry in the Age of Quantum Computing
DOI: 10.1021/acs.chemrev.8b00803

Selective Catalytic Reduction of NOx with NH3 by Using Novel Catalysts: State of the Art and Future Prospects
DOI: 10.1021/acs.chemrev.9b00202

Dithienothiophenes at Work: Access to Mechanosensitive Fluorescent Probes, Chalcogen-Bonding Catalysis, and Beyond
DOI: 10.1021/acs.chemrev.9b00279

Conjugated Ynones in Organic Synthesis
DOI: 10.1021/acs.chemrev.9b00277


Journal of the American Chemical Society

***

Asymmetric Total Synthesis of (−)-Vinigrol
DOI: 10.1021/jacs.9b08983

Catalytic Cleavage of C(sp2)–C(sp2) Bonds with Rh-Carbynoids
Open Access Through ACS AuthorChoice
DOI: 10.1021/jacs.9b08632

Revisiting Kekulene: Synthesis and Single-Molecule Imaging
Open Access Through ACS AuthorChoice
DOI: 10.1021/jacs.9b07926

Para-Selective C–H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation
Open Access Through ACS AuthorChoice
DOI: 10.1021/jacs.9b07267

A Biomimetic Synthesis Elucidates the Origin of Preuisolactone A
DOI: 10.1021/jacs.9b08892


Journal of Chemical Education

***

Should Organic Chemistry Be Taught as Science?
DOI: 10.1021/acs.jchemed.9b00122

Arguing from Spectroscopic Evidence
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jchemed.9b00550

Design and Construction of a Low-Cost Arduino-Based pH Sensor for the Visually Impaired Using Universal pH Paper
DOI: 10.1021/acs.jchemed.9b00450

Would We Have Chemistry without Marvelous Metals?
DOI: 10.1021/acs.jchemed.9b00865

Chemistry and Mathematics: Research and Frameworks To Explore Student Reasoning
DOI: 10.1021/acs.jchemed.9b00523

 

Discover the Most-Read Materials Science and Engineering Articles of October 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in October 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Get free monthly updates on the most-read research in your field.

Read more of October’s most-read articles.


ACS Applied Materials & Interfaces

***

Robust Graphene/Poly(vinyl alcohol) Janus Aerogels with a Hierarchical Architecture for Highly Efficient Switchable Separation of Oil/Water Emulsions
DOI: 10.1021/acsami.9b11277

Superhydrophobic Foams with Chemical- and Mechanical-Damage-Healing Abilities Enabled by Self-Healing Polymers
DOI: 10.1021/acsami.9b11858

Template-Free Nanostructured Fluorine-Doped Tin Oxide Scaffolds for Photoelectrochemical Water Splitting
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsami.9b05176

Flexible Anti-Biofouling MXene/Cellulose Fibrous Membrane for Sustainable Solar-Driven Water Purification
DOI: 10.1021/acsami.9b10606

Design and Biosensing of a Ratiometric Electrochemiluminescence Resonance Energy Transfer Aptasensor between a g-C3N4 Nanosheet and Ru@MOF for Amyloid-β Protein
DOI: 10.1021/acsami.9b09492


ACS Applied Bio Materials

***

Stimulus-Responsive Biopolymeric Surface: Molecular Switches for Oil/Water Separation
DOI: 10.1021/acsabm.9b00531

Aggregate Formation of BODIPY-Tethered Oligonucleotides That Led to Efficient Intracellular Penetration and Gene Regulation
DOI: 10.1021/acsabm.9b00631

Rapid and Reversible Reaction-Based Ratiometric Fluorescent Probe for Imaging of Different Glutathione Levels in Living Cells
DOI: 10.1021/acsabm.9b00642

Fabrication and Biomedical Applications of “Polymer-Like” Nucleic Acids Enzymatically Produced by Rolling Circle Amplification
DOI: 10.1021/acsabm.9b00622

Nanoparticle Assisted Remodeling of Proteotoxic SOD1 Mutants Alters the Biointerface of the Functional Interaction of Microtubules and Kinesin Motors
DOI: 10.1021/acsabm.9b00501


ACS Applied Electronic Materials

***

Performance Enhancement of All-Inorganic Quantum Dot Light-Emitting Diodes via Surface Modification of Nickel Oxide Nanoparticles Hole Transport Layer
DOI: 10.1021/acsaelm.9b00479

Unidirectional Threshold Switching Induced by Cu Migration with High Selectivity and Ultralow OFF Current under Gradual Electroforming Treatment
DOI: 10.1021/acsaelm.9b00446

Exfoliated Graphite Electrodes for Organic Single-Crystal Field-Effect Transistor Devices
DOI: 10.1021/acsaelm.9b00538

Solution-Processed Layered Hexagonal Boron Nitride Dielectrics: A Route toward Fabrication of High Performance Flexible Devices
DOI: 10.1021/acsaelm.9b00500

Controllable Self-Assembly of PTCDI-C8 for High Mobility Low-Dimensional Organic Field-Effect Transistors
DOI: 10.1021/acsaelm.9b00383


ACS Applied Energy Materials

***

Unlocking the Potential of Fluoride-Based Solid Electrolytes for Solid-State Lithium Batteries
DOI: 10.1021/acsaem.9b01166

An Efficient Synthetic Method to Prepare High-Performance Ni-rich LiNi0.8Co0.1Mn0.1O2 for Lithium-Ion Batteries
DOI: 10.1021/acsaem.9b01414

Realizing High Thermoelectric Performance in GeTe through Optimizing Ge Vacancies and Manipulating Ge Precipitates
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsaem.9b01585

Long-Lived Multilayer Coatings for Smart Windows: Integration of Energy-Saving, Antifogging, and Self-Healing Functions
DOI: 10.1021/acsaem.9b01382

Stabilizing Capacity Retention in NMC811/Graphite Full Cells via TMSPi Electrolyte Additives
DOI: 10.1021/acsaem.9b00727


ACS Applied Nano Materials

***

Gold Nanostars for the Detection of Foodborne Pathogens via Surface-Enhanced Raman Scattering Combined with Microfluidics
DOI: 10.1021/acsanm.9b01223

Disulfide-Bridged Chitosan-Eudragit S-100 Nanoparticles for Colorectal Cancer
DOI: 10.1021/acsanm.9b01377

Transparent Conductive Films Derived from Single-Walled Aluminosilicate Nanotubes
DOI: 10.1021/acsanm.9b01580

Wireless Nanobioelectronics for Electrical Intracellular Sensing
DOI: 10.1021/acsanm.9b01374

Improved CO Oxidation via Surface Stabilization of Ceria Nanoparticles Induced by Rare-Earth Metal Dopants
DOI: 10.1021/acsanm.9b01416


ACS Applied Polymer Materials

***

Sustainable Polyimidazolium Networks as Versatile Hydrogel Materials
Open Access through ACS AuthorChoice
DOI: 10.1021/acsapm.9b00491

Tough Polymeric Hydrogels Formed by Natural Glycyrrhetinic Acid-Tailored Host–Guest Macro-Cross-Linking toward Biocompatible Materials
DOI: 10.1021/acsapm.9b00723

Fast Photochromic Dye Response in Rigid Block Polymer Thermosets
DOI: 10.1021/acsapm.9b00741

Simple Theoretical Model for Thermal Conductivity of Crystalline Polymers
DOI: 10.1021/acsapm.9b00605

Simple Design for Durable and Clear Self-Cleaning Coatings
DOI: 10.1021/acsapm.9b00596


ACS Biomaterials Science & Engineering

***

Nanosilica: Recent Progress in Synthesis, Functionalization, Biocompatibility, and Biomedical Applications
DOI: 10.1021/acsbiomaterials.9b00464

Exosomes as Carriers for Antitumor Therapy
DOI: 10.1021/acsbiomaterials.9b00417

How Functionalized Surfaces Can Inhibit Bacterial Adhesion and Viability
DOI: 10.1021/acsbiomaterials.9b00849

Differentiation of Bioengineered Skeletal Muscle within a 3D Printed Perfusion Bioreactor Reduces Atrophic and Inflammatory Gene Expression
DOI: 10.1021/acsbiomaterials.9b00975

Biodegradable Microneedle Patch Delivering Antigenic Peptide–Hyaluronate Conjugate for Cancer Immunotherapy
DOI: 10.1021/acsbiomaterials.9b00961


ACS Catalysis

***

Recent Advances in Pyridinium Salts as Radical Reservoirs in Organic Synthesis
DOI: 10.1021/acscatal.9b03084

Catalysis of Organic Reactions through Halogen Bonding
DOI: 10.1021/acscatal.9b02894

Nickel/Cobalt-Catalyzed C(sp3)–C(sp3) Cross-Coupling of Alkyl Halides with Alkyl Tosylates
DOI: 10.1021/acscatal.9b03352

Gold-Catalyzed C–H Functionalization with Aryl Germanes
DOI: 10.1021/acscatal.9b02841

A General Route to Bicyclo[1.1.1]pentanes through Photoredox Catalysis
DOI: 10.1021/acscatal.9b03190


ACS Energy Letters

***

Organic Solar Cells: Recent Progress and Challenges
DOI: 10.1021/acsenergylett.9b02071

Three Pillars of Effective Research. Measurements, Analysis, and Dissemination – A Virtual Issue
DOI: 10.1021/acsenergylett.9b01946

Electronic Structure of the Plasmons in Metal Nanocrystals: Fundamental Limitations for the Energy Efficiency of Hot Electron Generation
DOI: 10.1021/acsenergylett.9b01617

Reversible Removal of Intermixed Shallow States by Light Soaking in Multication Mixed Halide Perovskite Films
Open Access through ACS AuthorChoice
DOI: 10.1021/acsenergylett.9b01726

Reversible Color Switching in Dual-Emitting Mn(II)-Doped CsPbBr3 Perovskite Nanorods: Dilution versus Evaporation
DOI: 10.1021/acsenergylett.9b01702


ACS Macro Letters

***

Synthesis of Rapidly Surface Eroding Polyorthoesters and Polyacetals Using Thiol–ene Click Chemistry
DOI: 10.1021/acsmacrolett.9b00463

Ring-Opening Polymerization of N-Carboxyanhydride-Induced Self-Assembly for Fabricating Biodegradable Polymer Vesicles
DOI: 10.1021/acsmacrolett.9b00606

Physically Cross-Linked Hydrogel Based on Phenyl-1,3,5-triazine: Soft Scaffold with Aggregation-Induced Emission
DOI: 10.1021/acsmacrolett.9b00712

Telechelics Based on Catalytic Alternating Ring-Opening Metathesis Polymerization
DOI: 10.1021/acsmacrolett.9b00750

Pyridyl Disulfide Reaction Chemistry: An Efficient Strategy toward Redox-Responsive Cyclic Peptide–Polymer Conjugates
DOI: 10.1021/acsmacrolett.9b00538


ACS Nano

***

Nano as a Rosetta Stone: The Global Roles and Opportunities for Nanoscience and Nanotechnology
DOI: 10.1021/acsnano.9b08042

Nanotechnology Facets of the Periodic Table of Elements
DOI: 10.1021/acsnano.9b06998

Morphological and Structural Evolution of Co3O4 Nanoparticles Revealed by in Situ Electrochemical Transmission Electron Microscopy during Electrocatalytic Water Oxidation
DOI: 10.1021/acsnano.9b04745

Tracking Single Molecules in Biomembranes: Is Seeing Always Believing?
DOI: 10.1021/acsnano.9b07445

Microcarrier-Assisted Inorganic Shelling of Lead Halide Perovskite Nanocrystals
DOI: 10.1021/acsnano.9b05481


ACS Photonics

***

Conditions for Enhancing Chiral Nanophotonics near Achiral Nanoparticles
DOI: 10.1021/acsphotonics.9b01200

High-Gyrotropy Seedlayer-Free Ce:TbIG for Monolithic Laser-Matched SOI Optical Isolators
DOI: 10.1021/acsphotonics.9b00707

Tuning Vibrational Strong Coupling with Co-Resonators
DOI: 10.1021/acsphotonics.9b01040

Tunable Light Emission by Electrically Excited Plasmonic Antenna
DOI: 10.1021/acsphotonics.9b00954

Correlative Dark-Field and Photoluminescence Spectroscopy of Individual Plasmon–Molecule Hybrid Nanostructures in a Strong Coupling Regime
DOI: 10.1021/acsphotonics.9b01079


ACS Sensors

***

Can Fish and Cell Phones Teach Us about Our Health?
Open Access through ACS Editors’ Choice
DOI: 10.1021/acssensors.9b00947

Tailor-Made Engineering of Bioinspired Inks for Writing Barcode-like Multifunctional Sensory Electronics
Open Access through ACS AuthorChoice
DOI: 10.1021/acssensors.9b01561

Ti3C2 MXene-Based Sensors with High Selectivity for NH3 Detection at Room Temperature
DOI: 10.1021/acssensors.9b01308

On-the-Spot Detection and Speciation of Cannabinoids Using Organic Thin-Film Transistors
DOI: 10.1021/acssensors.9b01150

So Long and Thanks for All (the Information from) the Fish
DOI: 10.1021/acssensors.9b01910


ACS Sustainable Chemistry & Engineering

***

Elucidation of In Situ Ligninolysis Mechanisms of the Selective White-Rot Fungus Ceriporiopsis subvermispora
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.9b04235

Vibrationally Excited Activation of N2 in Plasma-Enhanced Catalytic Ammonia Synthesis: A Kinetic Analysis
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.9b04997

Production of Nanocellulose and Its Applications in Drug Delivery: A Critical Review
DOI: 10.1021/acssuschemeng.9b02744

Multistep Solvent-Free 3 m2 Footprint Pilot Miniplant for the Synthesis of Annual Half-Ton Rufinamide Precursor
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.9b03931

Oxalic Acid Recovery from High Iron Oxalate Waste Solution by a Combination of Ultrasound-Assisted Conversion and Cooling Crystallization
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.9b04351


Bioconjugate Chemistry

***

Antibody–Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents
DOI: 10.1021/acs.bioconjchem.9b00306

Dual Site-Specific Labeling of an Antibody Fragment through Sortase A and π-Clamp Conjugation
DOI: 10.1021/acs.bioconjchem.9b00639

Targeted, Stimuli-Responsive, and Theranostic 19F Magnetic Resonance Imaging Probes
DOI: 10.1021/acs.bioconjchem.9b00582

Zwitterionic Modification of Nanomaterials for Improved Diagnosis of Cancer Cells
DOI: 10.1021/acs.bioconjchem.9b00543

Copper-64 Labeled PEGylated Exosomes for In Vivo Positron Emission Tomography and Enhanced Tumor Retention
DOI: 10.1021/acs.bioconjchem.9b00587


Biomacromolecules

***

Charge-Based Separation of Proteins Using Polyelectrolyte Complexes as Models for Membraneless Organelles
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b00701

Predicting Protein–Polymer Block Copolymer Self-Assembly from Protein Properties
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b00768

Extracellular Antifreeze Protein Significantly Enhances the Cryopreservation of Cell Monolayers
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b00951

Dimethyl Sulfoxide-Free Cryopreservation of Chondrocytes Based on Zwitterionic Molecule and Polymers
DOI: 10.1021/acs.biomac.9b01024

Nature of Amorphous Hydrophilic Block Affects Self-Assembly of an Artificial Viral Coat Polypeptide
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b00512


Chemistry of Materials

***

Virtual Issue on Machine-Learning Discoveries in Materials Science
DOI: 10.1021/acs.chemmater.9b03854

An Entropically Stabilized Fast-Ion Conductor: Li3.25[Si0.25P0.75]S4
DOI: 10.1021/acs.chemmater.9b00657

Supramolecular Self-Assembly To Control Structural and Biological Properties of Multicomponent Hydrogels
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.chemmater.9b01882

The Chemistry Women Mentorship Network (ChemWMN): A Tool for Creating Critical Mass in Academic Chemistry
DOI: 10.1021/acs.chemmater.9b03827

Fluorinated Covalent Organic Polymers for High Performance Sulfur Cathodes in Lithium–Sulfur Batteries
DOI: 10.1021/acs.chemmater.9b01986


Crystal Growth & Design

***

The Anisotropic Responses of a Flexible Metal–Organic Framework Constructed from Asymmetric Flexible Linkers and Heptanuclear Zinc Carboxylate Secondary Building Units
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.cgd.9b00558

The Ostwald Ratio, Kinetic Phase Diagrams, and Polymorph Maps
DOI: 10.1021/acs.cgd.9b00815

Estimation of the Growth and the Dissolution Kinetics of Ammonium Bicarbonate in Aqueous Ammonia Solutions from Batch Crystallization Experiments
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.cgd.9b00941

In Honor of Professor Xintao Wu on the Occasion of His Eightieth Birthday
DOI: 10.1021/acs.cgd.9b01106

Computed X-ray Tomography Study of Carbonate Precipitation in Large Portland Cement Pores
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.cgd.9b00864


Energy & Fuels

***

Asphaltene and Maltene Adsorption into Graphene
DOI: 10.1021/acs.energyfuels.9b01681

A Review of Numerical Modeling and Experimental Analysis of Combustion in Moving Grate Biomass Combustors
DOI: 10.1021/acs.energyfuels.9b02073

Wetting of Mineral Surfaces by Fatty-Acid-Laden Oil and Brine: Carbonate Effect at Elevated Temperature
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.energyfuels.9b01351

Food and Market Waste–A Pathway to Sustainable Fuels and Waste Valorization
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.energyfuels.9b01650

Camphorane as a Renewable Diesel Blendstock Produced by Cyclodimerization of Myrcene
DOI: 10.1021/acs.energyfuels.9b02557


Industrial & Engineering Chemistry Research

***

Announcing the 2019 Class of Influential Researchers
DOI: 10.1021/acs.iecr.9b05242

Synthesis and Physicochemical Characterization of Shaped Catalysts of β and Y Zeolites for Cyclization of Citronellal
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.iecr.9b02829

NASCRE-4 Editorial
DOI: 10.1021/acs.iecr.9b04913

110th Anniversary: Surrogate Models Based on Artificial Neural Networks To Simulate and Optimize Pressure Swing Adsorption Cycles for CO2 Capture
DOI: 10.1021/acs.iecr.9b02383

Boron Nitride Nanosheets from Different Preparations and Correlations with Their Material Properties
DOI: 10.1021/acs.iecr.9b03930


Inorganic Chemistry

***

The Chemistry Women Mentorship Network (ChemWMN): A Tool for Creating Critical Mass in Academic Chemistry
DOI: 10.1021/acs.inorgchem.9b02707

Metals in Biology: From Metallomics to Trafficking
DOI: 10.1021/acs.inorgchem.9b02965

Structure and Properties of a Five-Coordinate Nickel(II) Porphyrin
DOI: 10.1021/acs.inorgchem.9b00348

Inorganic Chemistry Approaches to Activity-Based Sensing: From Metal Sensors to Bioorthogonal Metal Chemistry
DOI: 10.1021/acs.inorgchem.9b01221

Spectroscopic X-ray and Mössbauer Characterization of M6 and M5 Iron(Molybdenum)-Carbonyl Carbide Clusters: High Carbide-Iron Covalency Enhances Local Iron Site Electron Density Despite Cluster Oxidation
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.inorgchem.9b01870


Journal of Chemical & Engineering Data

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Highlighting 10 Years of NIST Cooperation and Service to the Thermophysical Properties Data Community
DOI: 10.1021/acs.jced.9b00920

Experimental Study on the Hydrate Phase Equilibrium of Synthetic Natural Gas Containing H2S
DOI: 10.1021/acs.jced.9b00510

Solubility of Gastrodin in Pure and Mixed Solvents at 273.15–313.15 K and Its Correlation with Different Thermodynamic Models
DOI: 10.1021/acs.jced.9b00286

Solid–Liquid Phase Equilibria in the Ternary Systems NaCl–ZnCl2–H2O and CaCl2–ZnCl2–H2O at 323 K
DOI: 10.1021/acs.jced.9b00422

Lanthanum and Cerium Separation Using an Aqueous Two-Phase System with Ionic Liquid
DOI: 10.1021/acs.jced.9b00293


The Journal of Physical Chemistry C

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Taking the Heat Off of Plasmonic Chemistry
DOI: 10.1021/acs.jpcc.9b08143

Surface Premelting and Interfacial Interactions of Semi-Clathrate Hydrate
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.9b06376

Electronic–Vibrational Coupling and Electron Transfer
DOI: 10.1021/acs.jpcc.9b03849

Surface-Specific Spectroscopy of Water at a Potentiostatically Controlled Supported Graphene Monolayer
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.9b05844

The Mechanism of Dedoping PEDOT:PSS by Aliphatic Polyamines
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.9b07718


The Journal of Physical Chemistry Letters

***

The Causes of Degradation of Perovskite Solar Cells
DOI: 10.1021/acs.jpclett.9b00613

Two Dimensions Are Better for Perovskites
DOI: 10.1021/acs.jpclett.9b01568

Phospholipid Scramblases Remodel the Shape of Asymmetric Membranes
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.9b02531

Journey of Making Cesium Lead Halide Perovskite Nanocrystals: What’s Next
DOI: 10.1021/acs.jpclett.9b02412

Outstanding Challenges of Zero-Dimensional Perovskite Materials
DOI: 10.1021/acs.jpclett.9b00175


Langmuir

***

Five Easy Ways To Make Your Research More Reproducible
DOI: 10.1021/acs.langmuir.9b02963

Water-in-Oil Pickering Emulsions Stabilized by Synergistic Particle–Particle Interactions
Open Access Through AuthorChoice
DOI: 10.1021/acs.langmuir.9b02026

Bioinert and Lubricious Surfaces by Macromolecular Design
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.langmuir.9b02316

Investigating the Role of Lipid Transfer in Microbubble-Mediated Drug Delivery
Open Access Through AuthorChoice
DOI: 10.1021/acs.langmuir.9b02404

Surface Nanodroplets: Formation, Dissolution, and Applications
DOI: 10.1021/acs.langmuir.9b01051


Macromolecules

***

Processing Pathways Decide Polymer Properties at the Molecular Level
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.macromol.9b01195

Architectural Code for Rubber Elasticity: From Supersoft to Superfirm Materials
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.macromol.9b01127

Editorial
DOI: 10.1021/acs.macromol.9b01833

Polymerization-Induced Self-Assembly via RAFT-Mediated Emulsion Polymerization of Methacrylic Monomers
DOI: 10.1021/acs.macromol.9b01689

Better RAFT Control is Better? Insights into the Preparation of Monodisperse Surface-Functional Polymeric Microspheres by Photoinitiated RAFT Dispersion Polymerization
DOI: 10.1021/acs.macromol.9b01295


Nano Letters

***

Yolk–Shell Structured Au Nanostar@Metal–Organic Framework for Synergistic Chemo-photothermal Therapy in the Second Near-Infrared Window
DOI: 10.1021/acs.nanolett.9b01716

Redox-Activated Porphyrin-Based Liposome Remote-Loaded with Indoleamine 2,3-Dioxygenase (IDO) Inhibitor for Synergistic Photoimmunotherapy through Induction of Immunogenic Cell Death and Blockage of IDO Pathway
DOI: 10.1021/acs.nanolett.9b02306

Quantitative Drug Release Monitoring in Tumors of Living Subjects by Magnetic Particle Imaging Nanocomposite
DOI: 10.1021/acs.nanolett.9b01202

Nanoparticle Size Influences Antigen Retention and Presentation in Lymph Node Follicles for Humoral Immunity
DOI: 10.1021/acs.nanolett.9b02834

Plasmonic Microneedle Arrays for in Situ Sensing with Surface-Enhanced Raman Spectroscopy (SERS)
DOI: 10.1021/acs.nanolett.9b02070

Discover the Most-Read Applied Chemistry Articles of October 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in October 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Get free monthly updates on the most-read research in your field.

Read more of October’s most-read articles.


ACS Applied Materials & Interfaces

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Robust Graphene/Poly(vinyl alcohol) Janus Aerogels with a Hierarchical Architecture for Highly Efficient Switchable Separation of Oil/Water Emulsions
DOI: 10.1021/acsami.9b11277

Superhydrophobic Foams with Chemical- and Mechanical-Damage-Healing Abilities Enabled by Self-Healing Polymers
DOI: 10.1021/acsami.9b11858

Template-Free Nanostructured Fluorine-Doped Tin Oxide Scaffolds for Photoelectrochemical Water Splitting
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsami.9b05176

Flexible Anti-Biofouling MXene/Cellulose Fibrous Membrane for Sustainable Solar-Driven Water Purification
DOI: 10.1021/acsami.9b10606

Design and Biosensing of a Ratiometric Electrochemiluminescence Resonance Energy Transfer Aptasensor between a g-C3N4 Nanosheet and Ru@MOF for Amyloid-β Protein
DOI: 10.1021/acsami.9b09492


ACS Applied Bio Materials

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Stimulus-Responsive Biopolymeric Surface: Molecular Switches for Oil/Water Separation
DOI: 10.1021/acsabm.9b00531

Aggregate Formation of BODIPY-Tethered Oligonucleotides That Led to Efficient Intracellular Penetration and Gene Regulation
DOI: 10.1021/acsabm.9b00631

Rapid and Reversible Reaction-Based Ratiometric Fluorescent Probe for Imaging of Different Glutathione Levels in Living Cells
DOI: 10.1021/acsabm.9b00642

Fabrication and Biomedical Applications of “Polymer-Like” Nucleic Acids Enzymatically Produced by Rolling Circle Amplification
DOI: 10.1021/acsabm.9b00622

Nanoparticle Assisted Remodeling of Proteotoxic SOD1 Mutants Alters the Biointerface of the Functional Interaction of Microtubules and Kinesin Motors
DOI: 10.1021/acsabm.9b00501


ACS Applied Electronic Materials

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Performance Enhancement of All-Inorganic Quantum Dot Light-Emitting Diodes via Surface Modification of Nickel Oxide Nanoparticles Hole Transport Layer
DOI: 10.1021/acsaelm.9b00479

Unidirectional Threshold Switching Induced by Cu Migration with High Selectivity and Ultralow OFF Current under Gradual Electroforming Treatment
DOI: 10.1021/acsaelm.9b00446

Exfoliated Graphite Electrodes for Organic Single-Crystal Field-Effect Transistor Devices
DOI: 10.1021/acsaelm.9b00538

Solution-Processed Layered Hexagonal Boron Nitride Dielectrics: A Route toward Fabrication of High Performance Flexible Devices
DOI: 10.1021/acsaelm.9b00500

Controllable Self-Assembly of PTCDI-C8 for High Mobility Low-Dimensional Organic Field-Effect Transistors
DOI: 10.1021/acsaelm.9b00383


ACS Applied Energy Materials

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Unlocking the Potential of Fluoride-Based Solid Electrolytes for Solid-State Lithium Batteries
DOI: 10.1021/acsaem.9b01166

An Efficient Synthetic Method to Prepare High-Performance Ni-rich LiNi0.8Co0.1Mn0.1O2 for Lithium-Ion Batteries
DOI: 10.1021/acsaem.9b01414

Realizing High Thermoelectric Performance in GeTe through Optimizing Ge Vacancies and Manipulating Ge Precipitates
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsaem.9b01585

Long-Lived Multilayer Coatings for Smart Windows: Integration of Energy-Saving, Antifogging, and Self-Healing Functions
DOI: 10.1021/acsaem.9b01382

Stabilizing Capacity Retention in NMC811/Graphite Full Cells via TMSPi Electrolyte Additives
DOI: 10.1021/acsaem.9b00727


ACS Applied Nano Materials

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Gold Nanostars for the Detection of Foodborne Pathogens via Surface-Enhanced Raman Scattering Combined with Microfluidics
DOI: 10.1021/acsanm.9b01223

Disulfide-Bridged Chitosan-Eudragit S-100 Nanoparticles for Colorectal Cancer
DOI: 10.1021/acsanm.9b01377

Transparent Conductive Films Derived from Single-Walled Aluminosilicate Nanotubes
DOI: 10.1021/acsanm.9b01580

Wireless Nanobioelectronics for Electrical Intracellular Sensing
DOI: 10.1021/acsanm.9b01374

Improved CO Oxidation via Surface Stabilization of Ceria Nanoparticles Induced by Rare-Earth Metal Dopants
DOI: 10.1021/acsanm.9b01416


ACS Applied Polymer Materials

***

Sustainable Polyimidazolium Networks as Versatile Hydrogel Materials
Open Access through ACS AuthorChoice
DOI: 10.1021/acsapm.9b00491

Tough Polymeric Hydrogels Formed by Natural Glycyrrhetinic Acid-Tailored Host–Guest Macro-Cross-Linking toward Biocompatible Materials
DOI: 10.1021/acsapm.9b00723

Fast Photochromic Dye Response in Rigid Block Polymer Thermosets
DOI: 10.1021/acsapm.9b00741

Simple Theoretical Model for Thermal Conductivity of Crystalline Polymers
DOI: 10.1021/acsapm.9b00605

Simple Design for Durable and Clear Self-Cleaning Coatings
DOI: 10.1021/acsapm.9b00596


ACS Biomaterials Science & Engineering

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Nanosilica: Recent Progress in Synthesis, Functionalization, Biocompatibility, and Biomedical Applications
DOI: 10.1021/acsbiomaterials.9b00464

Exosomes as Carriers for Antitumor Therapy
DOI: 10.1021/acsbiomaterials.9b00417

How Functionalized Surfaces Can Inhibit Bacterial Adhesion and Viability
DOI: 10.1021/acsbiomaterials.9b00849

Differentiation of Bioengineered Skeletal Muscle within a 3D Printed Perfusion Bioreactor Reduces Atrophic and Inflammatory Gene Expression
DOI: 10.1021/acsbiomaterials.9b00975

Biodegradable Microneedle Patch Delivering Antigenic Peptide–Hyaluronate Conjugate for Cancer Immunotherapy
DOI: 10.1021/acsbiomaterials.9b00961


ACS Combinatorial Science

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A Solution Phase Platform to Characterize Chemical Reaction Compatibility with DNA-Encoded Chemical Library Synthesis
DOI: 10.1021/acscombsci.9b00113

Visible-Light-Initiated One-Pot, Three-Component Synthesis of 2-Amino-4H-pyran-3,5-dicarbonitrile Derivatives
DOI: 10.1021/acscombsci.9b00124

Multicomponent Approach to Libraries of Substituted Dihydroorotic Acid Amides
DOI: 10.1021/acscombsci.9b00144

Enzyme Degassing for Oxygen-Sensitive Reactions in Open Vessels of an Automated Parallel Synthesizer: RAFT Polymerizations
DOI: 10.1021/acscombsci.9b00082

Scanning Electrochemical Flow Cell with Online Mass Spectroscopy for Accelerated Screening of Carbon Dioxide Reduction Electrocatalysts
DOI: 10.1021/acscombsci.9b00130


ACS Energy Letters

***

Organic Solar Cells: Recent Progress and Challenges
DOI: 10.1021/acsenergylett.9b02071

Three Pillars of Effective Research. Measurements, Analysis, and Dissemination – A Virtual Issue
DOI: 10.1021/acsenergylett.9b01946

Electronic Structure of the Plasmons in Metal Nanocrystals: Fundamental Limitations for the Energy Efficiency of Hot Electron Generation
DOI: 10.1021/acsenergylett.9b01617

Reversible Removal of Intermixed Shallow States by Light Soaking in Multication Mixed Halide Perovskite Films
Open Access through ACS AuthorChoice
DOI: 10.1021/acsenergylett.9b01726

Reversible Color Switching in Dual-Emitting Mn(II)-Doped CsPbBr3 Perovskite Nanorods: Dilution versus Evaporation
DOI: 10.1021/acsenergylett.9b01702


ACS Infectious Diseases

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Modification at the 2′-Position of the 4,5-Series of 2-Deoxystreptamine Aminoglycoside Antibiotics To Resist Aminoglycoside Modifying Enzymes and Increase Ribosomal Target Selectivity
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsinfecdis.9b00128

Targeting Hepatitis B Virus Covalently Closed Circular DNA and Hepatitis B Virus X Protein: Recent Advances and New Approaches
DOI: 10.1021/acsinfecdis.9b00249

Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206
DOI: 10.1021/acsinfecdis.9b00217

Size Matters and How You Measure It: A Gram-Negative Antibacterial Example Exceeding Typical Molecular Weight Limits
DOI: 10.1021/acsinfecdis.9b00256

Sugar-Modified Analogs of Auranofin Are Potent Inhibitors of the Gastric Pathogen Helicobacter pylori
DOI: 10.1021/acsinfecdis.9b00251


ACS Medicinal Chemistry Letters

***

PROTAC-Mediated Degradation of Estrogen Receptor in the Treatment of Cancer
DOI: 10.1021/acsmedchemlett.9b00397

Synthesis and Evaluation of Camptothecin Antibody–Drug Conjugates
Open Access through ACS AuthorChoice
DOI: 10.1021/acsmedchemlett.9b00301

“AβTau”, Lobby or Religion?
DOI: 10.1021/acsmedchemlett.9b00439

PROTAC Degradation of IRAK4 for the Treatment of Cancer
DOI: 10.1021/acsmedchemlett.9b00423

Peptide-Cleavable Self-immolative Maytansinoid Antibody–Drug Conjugates Designed To Provide Improved Bystander Killing
Open Access through ACS AuthorChoice
DOI: 10.1021/acsmedchemlett.9b00310


ACS Sensors

***

Can Fish and Cell Phones Teach Us about Our Health?
Open Access through ACS Editors’ Choice
DOI: 10.1021/acssensors.9b00947

Tailor-Made Engineering of Bioinspired Inks for Writing Barcode-like Multifunctional Sensory Electronics
Open Access through ACS AuthorChoice
DOI: 10.1021/acssensors.9b01561

Ti3C2 MXene-Based Sensors with High Selectivity for NH3 Detection at Room Temperature
DOI: 10.1021/acssensors.9b01308

On-the-Spot Detection and Speciation of Cannabinoids Using Organic Thin-Film Transistors
DOI: 10.1021/acssensors.9b01150

So Long and Thanks for All (the Information from) the Fish
DOI: 10.1021/acssensors.9b01910


ACS Sustainable Chemistry & Engineering

***

Elucidation of In Situ Ligninolysis Mechanisms of the Selective White-Rot Fungus Ceriporiopsis subvermispora
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.9b04235

Vibrationally Excited Activation of N2 in Plasma-Enhanced Catalytic Ammonia Synthesis: A Kinetic Analysis
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.9b04997

Production of Nanocellulose and Its Applications in Drug Delivery: A Critical Review
DOI: 10.1021/acssuschemeng.9b02744

Multistep Solvent-Free 3 m2 Footprint Pilot Miniplant for the Synthesis of Annual Half-Ton Rufinamide Precursor
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.9b03931

Oxalic Acid Recovery from High Iron Oxalate Waste Solution by a Combination of Ultrasound-Assisted Conversion and Cooling Crystallization
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.9b04351


ACS Synthetic Biology

***

Exploiting Day- and Night-Time Metabolism of Synechocystis sp. PCC 6803 for Fitness-Coupled Fumarate Production around the Clock
Open Access through ACS AuthorChoice
DOI: 10.1021/acssynbio.9b00289

An AND-Gated Drug and Photoactivatable Cre-loxP System for Spatiotemporal Control in Cell-Based Therapeutics
DOI: 10.1021/acssynbio.9b00175

Mevalonate Pathway Promiscuity Enables Noncanonical Terpene Production
DOI: 10.1021/acssynbio.9b00230

HOLMESv2: A CRISPR-Cas12b-Assisted Platform for Nucleic Acid Detection and DNA Methylation Quantitation
DOI: 10.1021/acssynbio.9b00209

Modular Thermal Control of Protein Dimerization
DOI: 10.1021/acssynbio.9b00275


Analytical Chemistry

***

Bacterial Extracellular Electron Transfer Occurs in Mammalian Gut
DOI: 10.1021/acs.analchem.9b03176

Is Infrared Spectroscopy Ready for the Clinic?
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.analchem.9b02280

Laser Spectroscopy for Monitoring of Radiocarbon in Atmospheric Samples
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.analchem.9b02496

Photo-Scanning Electrochemical Microscopy on the Nanoscale with Through-Tip Illumination
DOI: 10.1021/acs.analchem.9b03347

Lysosome-Targeting Red-Emitting Aggregation-Induced Emission Probe with Large Stokes Shift for Light-Up in Situ Visualization of β-N-Acetylhexosaminidase
DOI: 10.1021/acs.analchem.9b03832


Chemical Research in Toxicology

***

Analysis of the Effects of Cr(VI) Exposure on mRNA Modifications
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.chemrestox.9b00249

A Strategy for Efficiently Collecting Aerosol Condensate Using Silica Fibers: Application to Carbonyl Emissions from E-Cigarettes
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.chemrestox.9b00214

From Basic Research in Toxicology to a Career in Regulatory Toxicology: An Industry Perspective
DOI: 10.1021/acs.chemrestox.9b00263

Reactivity of N3-Methyl-2′-Deoxyadenosine in Nucleosome Core Particles
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.chemrestox.9b00299

Exposure to Inorganic Arsenic and Lead and Autism Spectrum Disorder in Children: A Systematic Review and Meta-Analysis
DOI: 10.1021/acs.chemrestox.9b00134


Crystal Growth & Design

***

The Anisotropic Responses of a Flexible Metal–Organic Framework Constructed from Asymmetric Flexible Linkers and Heptanuclear Zinc Carboxylate Secondary Building Units
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.cgd.9b00558

The Ostwald Ratio, Kinetic Phase Diagrams, and Polymorph Maps
DOI: 10.1021/acs.cgd.9b00815

Estimation of the Growth and the Dissolution Kinetics of Ammonium Bicarbonate in Aqueous Ammonia Solutions from Batch Crystallization Experiments
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.cgd.9b00941

In Honor of Professor Xintao Wu on the Occasion of His Eightieth Birthday
DOI: 10.1021/acs.cgd.9b01106

Computed X-ray Tomography Study of Carbonate Precipitation in Large Portland Cement Pores
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.cgd.9b00864


Energy & Fuels

***

Asphaltene and Maltene Adsorption into Graphene
DOI: 10.1021/acs.energyfuels.9b01681

A Review of Numerical Modeling and Experimental Analysis of Combustion in Moving Grate Biomass Combustors
DOI: 10.1021/acs.energyfuels.9b02073

Wetting of Mineral Surfaces by Fatty-Acid-Laden Oil and Brine: Carbonate Effect at Elevated Temperature
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.energyfuels.9b01351

Food and Market Waste–A Pathway to Sustainable Fuels and Waste Valorization
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.energyfuels.9b01650

Camphorane as a Renewable Diesel Blendstock Produced by Cyclodimerization of Myrcene
DOI: 10.1021/acs.energyfuels.9b02557


Environmental Science & Technology

***

Benchmarking the in Vitro Toxicity and Chemical Composition of Plastic Consumer Products
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.est.9b02293

Defluorination of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) by Acidimicrobium sp. Strain A6
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.est.9b04047

Effects of Microplastics in Soil Ecosystems: Above and Below Ground
DOI: 10.1021/acs.est.9b03304

Solidification/Stabilization for Soil Remediation: An Old Technology with New Vitality
DOI: 10.1021/acs.est.9b04990

Chemical Composition and Toxicity of Particles Emitted from a Consumer-Level 3D Printer Using Various Materials
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.est.9b04168


Environmental Science & Technology Letters

***

Iron Lung: How Rice Roots Induce Iron Redox Changes in the Rhizosphere and Create Niches for Microaerophilic Fe(II)-Oxidizing Bacteria
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.estlett.9b00403

Exploring the Efficacy of Nile Red in Microplastic Quantification: A Costaining Approach
DOI: 10.1021/acs.estlett.9b00499

Background Antibiotic Resistance and Microbial Communities Dominate Effects of Advanced Purified Water Recharge to an Urban Aquifer
DOI: 10.1021/acs.estlett.9b00521

Rapid Destruction and Defluorination of Perfluorooctanesulfonate by Alkaline Hydrothermal Reaction
DOI: 10.1021/acs.estlett.9b00506

A Machine Learning Approach for Predicting Defluorination of Per- and Polyfluoroalkyl Substances (PFAS) for Their Efficient Treatment and Removal
DOI: 10.1021/acs.estlett.9b00476


Industrial & Engineering Chemistry Research

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Announcing the 2019 Class of Influential Researchers
DOI: 10.1021/acs.iecr.9b05242

Synthesis and Physicochemical Characterization of Shaped Catalysts of β and Y Zeolites for Cyclization of Citronellal
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.iecr.9b02829

NASCRE-4 Editorial
DOI: 10.1021/acs.iecr.9b04913

110th Anniversary: Surrogate Models Based on Artificial Neural Networks To Simulate and Optimize Pressure Swing Adsorption Cycles for CO2 Capture
DOI: 10.1021/acs.iecr.9b02383

Boron Nitride Nanosheets from Different Preparations and Correlations with Their Material Properties
DOI: 10.1021/acs.iecr.9b03930


Journal of Agricultural and Food Chemistry

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Identification of Novel Urolithin Metabolites in Human Feces and Urine after the Intake of a Pomegranate Extract
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.jafc.9b04435

Melanoidins from Coffee, Cocoa, and Bread Are Able to Scavenge α-Dicarbonyl Compounds under Simulated Physiological Conditions
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jafc.9b03744

Effect of Phytase on in Vitro Hydrolysis of Phytate and the Formation of myo-Inositol Phosphate Esters in Various Feed Materials
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jafc.9b03919

Fabrication of OSA Starch/Chitosan Polysaccharide-Based High Internal Phase Emulsion via Altering Interfacial Behaviors
DOI: 10.1021/acs.jafc.9b04009

New Acylated Phenolic Glycosides with ROS-Scavenging Activity from Psidium guajava Leaves
DOI: 10.1021/acs.jafc.9b04318


Journal of Chemical & Engineering Data

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Highlighting 10 Years of NIST Cooperation and Service to the Thermophysical Properties Data Community
DOI: 10.1021/acs.jced.9b00920

Experimental Study on the Hydrate Phase Equilibrium of Synthetic Natural Gas Containing H2S
DOI: 10.1021/acs.jced.9b00510

Solubility of Gastrodin in Pure and Mixed Solvents at 273.15–313.15 K and Its Correlation with Different Thermodynamic Models
DOI: 10.1021/acs.jced.9b00286

Solid–Liquid Phase Equilibria in the Ternary Systems NaCl–ZnCl2–H2O and CaCl2–ZnCl2–H2O at 323 K
DOI: 10.1021/acs.jced.9b00422

Lanthanum and Cerium Separation Using an Aqueous Two-Phase System with Ionic Liquid
DOI: 10.1021/acs.jced.9b00293


Journal of Chemical Information and Modeling

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TeachOpenCADD-KNIME: A Teaching Platform for Computer-Aided Drug Design Using KNIME Workflows
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.jcim.9b00662

Graph Convolutional Neural Networks for Predicting Drug-Target Interactions
DOI: 10.1021/acs.jcim.9b00628

A Quantum-Inspired Method for Three-Dimensional Ligand-Based Virtual Screening
DOI: 10.1021/acs.jcim.9b00195

Learning Drug Functions from Chemical Structures with Convolutional Neural Networks and Random Forests
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jcim.9b00236

Sharing Data from Molecular Simulations
DOI: 10.1021/acs.jcim.9b00665


Journal of Chemical Theory and Computation

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Pitfalls of the Martini Model
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00473

Self-Consistent Density-Functional Embedding: A Novel Approach for Density-Functional Approximations
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00063

Insights into Membrane Protein–Lipid Interactions from Free Energy Calculations
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00548

A Linear-Scaling Method for Noncovalent Interactions: An Efficient Combination of Absolutely Localized Molecular Orbitals and a Local Random Phase Approximation Approach
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00615

Accuracy of Spin-Component-Scaled CC2 Excitation Energies and Potential Energy Surfaces
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00676


Journal of Medicinal Chemistry

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Synthesis and Pharmacological Characterization of 2-(2,6-Dichlorophenyl)-1-((1S,3R)-5-(3-hydroxy-3-methylbutyl)-3-(hydroxymethyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one (LY3154207), a Potent, Subtype Selective, and Orally Available Positive Allosteric Modulator of the Human Dopamine D1 Receptor
DOI: 10.1021/acs.jmedchem.9b01234

Tyrosine Kinase 2 (TYK2) Allosteric Inhibitors To Treat Autoimmune Diseases
DOI: 10.1021/acs.jmedchem.9b01612

Antibiotic Adjuvants: Make Antibiotics Great Again!
DOI: 10.1021/acs.jmedchem.8b01781

Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165
DOI: 10.1021/acs.jmedchem.9b00444

Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases
DOI: 10.1021/acs.jmedchem.9b00533


The Journal of Physical Chemistry A

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Viewpoint on the 2019 International Conference on Photochemistry
DOI: 10.1021/acs.jpca.9b09156

Method for the Calculation of the Hamaker Constants of Organic Materials by the Lifshitz Macroscopic Approach with Density Functional Theory
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpca.9b06433

Hydrogen-Bonding Mediated Reactions of Criegee Intermediates in the Gas Phase: Competition between Bimolecular and Termolecular Reactions and the Catalytic Role of Water
DOI: 10.1021/acs.jpca.9b07117

International Year of the Periodic Table from a Physical Chemistry Perspective
DOI: 10.1021/acs.jpca.9b07024

Calculation of Free-Energy Barriers with TD-DFT: A Case Study on Excited-State Proton Transfer in Indigo
DOI: 10.1021/acs.jpca.9b05163


The Journal of Physical Chemistry B

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Proteins: “Boil ’Em, Mash ’Em, Stick ’Em in a Stew”
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.jpcb.9b05467

Physical Chemistry of Epigenetics: Single-Molecule Investigations
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.jpcb.9b06214

Insights into Proton-Transfer Pathways during Water Oxidation in Photosystem II
DOI: 10.1021/acs.jpcb.9b06244

Electrolytes Change the Interfacial Water Structure but Not the Vibrational Dynamics
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.9b08131

The Widom Line and the Lennard-Jones Potential
DOI: 10.1021/acs.jpcb.9b05426


The Journal of Physical Chemistry C

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Taking the Heat Off of Plasmonic Chemistry
DOI: 10.1021/acs.jpcc.9b08143

Surface Premelting and Interfacial Interactions of Semi-Clathrate Hydrate
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.9b06376

Electronic–Vibrational Coupling and Electron Transfer
DOI: 10.1021/acs.jpcc.9b03849

Surface-Specific Spectroscopy of Water at a Potentiostatically Controlled Supported Graphene Monolayer
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.9b05844

The Mechanism of Dedoping PEDOT:PSS by Aliphatic Polyamines
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.9b07718


The Journal of Physical Chemistry Letters

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The Causes of Degradation of Perovskite Solar Cells
DOI: 10.1021/acs.jpclett.9b00613

Two Dimensions Are Better for Perovskites
DOI: 10.1021/acs.jpclett.9b01568

Phospholipid Scramblases Remodel the Shape of Asymmetric Membranes
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.9b02531

Journey of Making Cesium Lead Halide Perovskite Nanocrystals: What’s Next
DOI: 10.1021/acs.jpclett.9b02412

Outstanding Challenges of Zero-Dimensional Perovskite Materials
DOI: 10.1021/acs.jpclett.9b00175


Journal of Proteome Research

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Common Repository of FBS Proteins (cRFP) To Be Added to a Search Database for Mass Spectrometric Analysis of Cell Secretome
DOI: 10.1021/acs.jproteome.9b00475

Current Understanding of Human Metaproteome Association and Modulation
DOI: 10.1021/acs.jproteome.9b00301

Chemical Derivatization of Affinity Matrices Provides Protection from Tryptic Proteolysis
DOI: 10.1021/acs.jproteome.9b00254

One Thousand and One Software for Proteomics: Tales of the Toolmakers of Science
DOI: 10.1021/acs.jproteome.9b00219

Extremely Fast and Accurate Open Modification Spectral Library Searching of High-Resolution Mass Spectra Using Feature Hashing and Graphics Processing Units
DOI: 10.1021/acs.jproteome.9b00291


Molecular Pharmaceutics

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Use of Terahertz-Raman Spectroscopy to Determine Solubility of the Crystalline Active Pharmaceutical Ingredient in Polymeric Matrices during Hot Melt Extrusion
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00703

Prediction of Bioequivalence and Food Effect Using Flux- and Solubility-Based Methods
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00406

Recent Advances in Understanding the Micro- and Nanoscale Phenomena of Amorphous Solid Dispersions
DOI: 10.1021/acs.molpharmaceut.9b00601

Scale-Independent Microfluidic Production of Cationic Liposomal Adjuvants and Development of Enhanced Lymphatic Targeting Strategies
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00730

From Target to Drug: Generative Modeling for the Multimodal Structure-Based Ligand Design
DOI: 10.1021/acs.molpharmaceut.9b00634


Organic Process Research & Development

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Some Items of Interest to Process R&D Chemists and Engineers
DOI: 10.1021/acs.oprd.9b00412

Explosion Hazards of Sodium Hydride in Dimethyl Sulfoxide, N,N-Dimethylformamide, and N,N-Dimethylacetamide
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.oprd.9b00276

The Role of Process Chemistry in Providing Healthy Food for a Healthy and Growing Planet
DOI: 10.1021/acs.oprd.9b00383

Applications of the 12 Principles of Green Chemistry in the Crop Protection Industry
DOI: 10.1021/acs.oprd.9b00305

Development of a Scalable Process for the Insecticidal Candidate Tyclopyrazoflor. Part 1. Evaluation of [3 + 2] Cyclization Strategies to 3-(3-Chloro-1H-pyrazol-1-yl)pyridine
DOI: 10.1021/acs.oprd.9b00127

Discover the Most-Read Analytical Chemistry Articles of October 2019

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in October 2019, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Get free monthly updates on the most-read research in your field.

Read more of October’s most-read articles.


ACS Earth and Space Chemistry

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Interstellar Formamide (NH2CHO), a Key Prebiotic Precursor
DOI: 10.1021/acsearthspacechem.9b00154

Complex Organic Molecules in Star-Forming Regions of the Magellanic Clouds
DOI: 10.1021/acsearthspacechem.9b00065

Formation of Secondary Organic Aerosol from the Heterogeneous Oxidation by Ozone of a Phytoplankton Culture
DOI: 10.1021/acsearthspacechem.9b00201

Characterization of Secondary Organic Aerosol Tracers over Tianjin, North China during Summer to Autumn
DOI: 10.1021/acsearthspacechem.9b00170

Chemical Characterization of Cloudwater Collected at Puy de Dôme by FT-ICR MS Reveals the Presence of SOA Components
DOI: 10.1021/acsearthspacechem.9b00153


ACS Sensors


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Can Fish and Cell Phones Teach Us about Our Health?
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acssensors.9b00947

Tailor-Made Engineering of Bioinspired Inks for Writing Barcode-like Multifunctional Sensory Electronics
Open Access Through ACS AuthorChoice
DOI: 10.1021/acssensors.9b01561

Ti3C2 MXene-Based Sensors with High Selectivity for NH3 Detection at Room Temperature
DOI: 10.1021/acssensors.9b01308

On-the-Spot Detection and Speciation of Cannabinoids Using Organic Thin-Film Transistors
DOI: 10.1021/acssensors.9b01150

So Long and Thanks for All (the Information from) the Fish
DOI: 10.1021/acssensors.9b01910


Analytical Chemistry


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Bacterial Extracellular Electron Transfer Occurs in Mammalian Gut
DOI: 10.1021/acs.analchem.9b03176

Is Infrared Spectroscopy Ready for the Clinic?
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.analchem.9b02280

Laser Spectroscopy for Monitoring of Radiocarbon in Atmospheric Samples
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.analchem.9b02496

Photo-Scanning Electrochemical Microscopy on the Nanoscale with Through-Tip Illumination
DOI: 10.1021/acs.analchem.9b03347

Lysosome-Targeting Red-Emitting Aggregation-Induced Emission Probe with Large Stokes Shift for Light-Up in Situ Visualization of β-N-Acetylhexosaminidase
DOI: 10.1021/acs.analchem.9b03832


Chemical Research in Toxicology


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Analysis of the Effects of Cr(VI) Exposure on mRNA Modifications
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.chemrestox.9b00249

A Strategy for Efficiently Collecting Aerosol Condensate Using Silica Fibers: Application to Carbonyl Emissions from E-Cigarettes
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.chemrestox.9b00214

From Basic Research in Toxicology to a Career in Regulatory Toxicology: An Industry Perspective
DOI: 10.1021/acs.chemrestox.9b00263

Reactivity of N3-Methyl-2′-Deoxyadenosine in Nucleosome Core Particles
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.chemrestox.9b00299

Exposure to Inorganic Arsenic and Lead and Autism Spectrum Disorder in Children: A Systematic Review and Meta-Analysis
DOI: 10.1021/acs.chemrestox.9b00134


Environmental Science & Technology

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Benchmarking the in Vitro Toxicity and Chemical Composition of Plastic Consumer Products
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.est.9b02293

Defluorination of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) by Acidimicrobium sp. Strain A6
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.est.9b04047

Effects of Microplastics in Soil Ecosystems: Above and Below Ground
DOI: 10.1021/acs.est.9b03304

Solidification/Stabilization for Soil Remediation: An Old Technology with New Vitality
DOI: 10.1021/acs.est.9b04990

Chemical Composition and Toxicity of Particles Emitted from a Consumer-Level 3D Printer Using Various Materials
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.est.9b04168


Environmental Science & Technology Letters

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Iron Lung: How Rice Roots Induce Iron Redox Changes in the Rhizosphere and Create Niches for Microaerophilic Fe(II)-Oxidizing Bacteria
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.estlett.9b00403

Exploring the Efficacy of Nile Red in Microplastic Quantification: A Costaining Approach
DOI: 10.1021/acs.estlett.9b00499

Background Antibiotic Resistance and Microbial Communities Dominate Effects of Advanced Purified Water Recharge to an Urban Aquifer
DOI: 10.1021/acs.estlett.9b00521

Rapid Destruction and Defluorination of Perfluorooctanesulfonate by Alkaline Hydrothermal Reaction
DOI: 10.1021/acs.estlett.9b00506

A Machine Learning Approach for Predicting Defluorination of Per- and Polyfluoroalkyl Substances (PFAS) for Their Efficient Treatment and Removal
DOI: 10.1021/acs.estlett.9b00476


Journal of Agricultural and Food Chemistry

***

Identification of Novel Urolithin Metabolites in Human Feces and Urine after the Intake of a Pomegranate Extract
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jafc.9b04435

Melanoidins from Coffee, Cocoa, and Bread Are Able to Scavenge α-Dicarbonyl Compounds under Simulated Physiological Conditions
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jafc.9b03744

Effect of Phytase on in Vitro Hydrolysis of Phytate and the Formation of myo-Inositol Phosphate Esters in Various Feed Materials
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jafc.9b03919

Fabrication of OSA Starch/Chitosan Polysaccharide-Based High Internal Phase Emulsion via Altering Interfacial Behaviors
DOI: 10.1021/acs.jafc.9b04009

New Acylated Phenolic Glycosides with ROS-Scavenging Activity from Psidium guajava Leaves
DOI: 10.1021/acs.jafc.9b04318


Journal of Proteome Research

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Common Repository of FBS Proteins (cRFP) To Be Added to a Search Database for Mass Spectrometric Analysis of Cell Secretome
DOI: 10.1021/acs.jproteome.9b00475

Current Understanding of Human Metaproteome Association and Modulation
DOI: 10.1021/acs.jproteome.9b00301

Chemical Derivatization of Affinity Matrices Provides Protection from Tryptic Proteolysis
DOI: 10.1021/acs.jproteome.9b00254

One Thousand and One Software for Proteomics: Tales of the Toolmakers of Science
DOI: 10.1021/acs.jproteome.9b00219

Extremely Fast and Accurate Open Modification Spectral Library Searching of High-Resolution Mass Spectra Using Feature Hashing and Graphics Processing Units
DOI: 10.1021/acs.jproteome.9b00291