February 2020

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in January, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Click on your favorite journal below to see their most-read articles of the month.

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Accounts of Chemical Research

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A Survival Guide for the “Electro-curious”
DOI: 10.1021/acs.accounts.9b00539

CO2 Reduction: From Homogeneous to Heterogeneous Electrocatalysis
DOI: 10.1021/acs.accounts.9b00496

Activity-Based Sensing: Achieving Chemical Selectivity through Chemical Reactivity
DOI: 10.1021/acs.accounts.9b00542

Metalla-electrocatalyzed C–H Activation by Earth-Abundant 3d Metals and Beyond
DOI: 10.1021/acs.accounts.9b00510

Anodic Oxidation for the Stereoselective Synthesis of Heterocycles
DOI: 10.1021/acs.accounts.9b00513

ACS Applied Bio Materials

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Young Investigator Forum of ACS Applied Bio Materials
DOI: 10.1021/acsabm.0c00005

Self-Assembly of Protamine Biomacromolecule on Halloysite Nanotubes for Immobilization of Superoxide Dismutase Enzyme
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsabm.9b00953

Supramolecular Nanodrugs Constructed by Self-Assembly of Peptide Nucleic Acid–Photosensitizer Conjugates for Photodynamic Therapy
DOI: 10.1021/acsabm.9b00558

Microfluidic Methods for Fabrication and Engineering of Nanoparticle Drug Delivery Systems
DOI: 10.1021/acsabm.9b00853

Self-Assembled Nanomaterials for Enhanced Phototherapy of Cancer
DOI: 10.1021/acsabm.9b00843

ACS Applied Electronic Materials

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Electronic Band Structure of In-Plane Ferroelectric van der Waals β′-In2Se3
DOI: 10.1021/acsaelm.9b00699

Design Rules for Memories Based on Graphene Ferroelectric Field-Effect Transistors
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsaelm.9b00532

Significant Performance Enhancement of Very Thin InGaZnO Thin-Film Transistors by a Self-Assembled Monolayer Treatment
DOI: 10.1021/acsaelm.9b00791

Fermi Level Pinning Induced by Doping in Air Stable n-Type Organic Semiconductor
DOI: 10.1021/acsaelm.9b00742

Young Investigator Forum in ACS Applied Electronic Materials
DOI: 10.1021/acsaelm.0c00023

ACS Applied Energy Materials

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Electrochemical Impedance Spectroscopy of Metal Oxide Electrodes for Energy Applications
DOI: 10.1021/acsaem.9b01965

ALD-Modified LiNi0.33Mn0.33Co0.33O2 Paired with Macroporous Silicon for Lithium-Ion Batteries: An Investigation on Lithium Trapping, Resistance Rise, and Cycle-Life Performance
DOI: 10.1021/acsaem.9b01728

Heavy-Atom-Free Red-to-Yellow Photon Upconversion in a Thiosquaraine Composite
DOI: 10.1021/acsaem.9b01808

All-Solid-State Batteries Using Rationally Designed Garnet Electrolyte Frameworks
DOI: 10.1021/acsaem.9b02101

Young Investigators Advance Energy Applications
DOI: 10.1021/acsaem.0c00022

ACS Applied Materials & Interfaces

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Water-Soluble 3D Covalent Organic Framework that Displays an Enhanced Enrichment Effect of Photosensitizers and Catalysts for the Reduction of Protons to H2
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsami.9b19870

Biomimetic Platinum Nanozyme Immobilized on 2D Metal–Organic Frameworks for Mitochondrion-Targeting and Oxygen Self-Supply Photodynamic Therapy
DOI: 10.1021/acsami.9b14958

Immobilized Enzymes on Graphene as Nanobiocatalyst
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsami.9b17777

Superhydrophobic Covalent Organic Frameworks Prepared via Pore Surface Modifications for Functional Coatings under Harsh Conditions
DOI: 10.1021/acsami.9b17319

Polymer Matrix Nanocomposites with 1D Ceramic Nanofillers for Energy Storage Capacitor Applications
DOI: 10.1021/acsami.9b15005

ACS Applied Nano Materials

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In-Situ X-ray Spectroscopy of the Electric Double Layer around TiO2 Nanoparticles Dispersed in Aqueous Solution: Implications for H2 Generation
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsanm.9b01939

Colorless Transparent Melamine–Formaldehyde Aerogels for Thermal Insulation
DOI: 10.1021/acsanm.9b02275

Pure and Efficient Single-Photon Sources by Shortening and Functionalizing Air-Suspended Carbon Nanotubes
DOI: 10.1021/acsanm.9b02209

Nanostructured Carbon Florets as Scavenger of As3+, Cr6+, Cd2+, and Hg2+ for Water Remediation
DOI: 10.1021/acsanm.9b02052

Metal and Metal Oxide Nanoparticles to Enhance the Performance of Enzyme-Linked Immunosorbent Assay (ELISA)
DOI: 10.1021/acsanm.9b02003

ACS Applied Polymer Materials

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Forum: Young Investigators in Applied Polymer Materials
DOI: 10.1021/acsapm.9b01186

Near-Infrared Polymer Dots with Aggregation-Induced Emission for Tumor Imaging
DOI: 10.1021/acsapm.9b00977

Copolymer-Based Photonic Crystal Sensor for Discriminative Detection of Liquid Benzene, Toluene, Ethylbenzene, and Xylene
DOI: 10.1021/acsapm.9b00580

Water–Alcohol-Soluble Hyperbranched Polyelectrolytes and Their Application in Polymer Solar Cells and Photocatalysis
DOI: 10.1021/acsapm.9b00859

Self-Assemblies of Thermoresponsive Poly(N-vinylcaprolactam) Polymers for Applications in Biomedical Field
DOI: 10.1021/acsapm.9b00863

ACS Biomaterials Science & Engineering

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Oligomer Length Defines the Self-Assembly of Single-Stranded DNA–Collagen Complex Fibers
DOI: 10.1021/acsbiomaterials.9b01435

Biomaterials Science and Engineering in the Middle East
DOI: 10.1021/acsbiomaterials.9b01970

Homogeneous Distribution of Magnetic, Antimicrobial-Carrying Nanoparticles through an Infectious Biofilm Enhances Biofilm-Killing Efficacy
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsbiomaterials.9b01425

Antimicrobial Bioresorbable Mg–Zn–Ca Alloy for Bone Repair in a Comparison Study with Mg–Zn–Sr Alloy and Pure Mg
DOI: 10.1021/acsbiomaterials.9b00903

Selective Contribution of Bioactive Glasses to Molecular and Cellular Pathways
DOI: 10.1021/acsbiomaterials.8b01078

ACS Catalysis

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CoP Nanoframes as Bifunctional Electrocatalysts for Efficient Overall Water Splitting
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acscatal.9b03623

Dialkylation of 1,3-Dienes by Dual Photoredox and Chromium Catalysis
DOI: 10.1021/acscatal.9b04222

Photoredox Ni-Catalyzed Branch-Selective Reductive Coupling of Aldehydes with 1,3-Dienes
DOI: 10.1021/acscatal.9b05137

Axially Chiral Biaryl Monophosphine Oxides Enabled by Palladium/WJ-Phos-Catalyzed Asymmetric Suzuki–Miyaura Cross-coupling
DOI: 10.1021/acscatal.9b04354

Synthesis of Highly Functionalized 12-Membered Trifluoromethyl Heterocycles via a Nondecarboxylative Pd-Catalyzed [6 + 6] Annulation
DOI: 10.1021/acscatal.9b05377

ACS Central Science

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A Scientist’s Guide to Social Media
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.9b01273

Building a Healthy Herd without Antibiotics
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c00009

Molecular and Crystal Features of Thermostable Energetic Materials: Guidelines for Architecture of “Bridged” Compounds
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.9b01096

An Activity-Based Methionine Bioconjugation Approach To Developing Proximity-Activated Imaging Reporters
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.9b01038

Protein Corona, with a Twist
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.9b01284

ACS Chemical Biology

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Assessing the Cell Permeability of Bivalent Chemical Degraders Using the Chloroalkane Penetration Assay
DOI: 10.1021/acschembio.9b00972

Processivity in Bacterial Glycosyltransferases
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschembio.9b00619

Inhibiting Mycobacterium tuberculosis DosRST Signaling by Targeting Response Regulator DNA Binding and Sensor Kinase Heme
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschembio.8b00849

Identification of a Small Probe That Can Be Conjugated to Proteins by Proximity Labeling
DOI: 10.1021/acschembio.9b00842

Augmented Reality in Scientific Publications – Taking the Visualization of 3D Structures to the Next Level
DOI: 10.1021/acschembio.9b00951

ACS Chemical Health & Safety

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Self-Designing Safety Culture: A Case Study in Adaptive Approaches to Creating a Safety Culture
DOI: 10.1021/acs.chas.0c00005

Safety Highlights
DOI: 10.1021/acs.chas.0c00009

Lessons Learned—Fluoride Exposure
DOI: 10.1021/acs.chas.9b00015

Development and Implementation of a Clinical Eyewash and Safety Shower Risk Assessment Process in an Academic Medical Center
DOI: 10.1021/acs.chas.9b00003

“Why Don’t We Just Put It in the Hood?”: Issues with Degrading Hood Effectiveness Due to Equipment Placement
DOI: 10.1021/acs.chas.9b00017

ACS Chemical Neuroscience

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Kinetic Control of Amyloidogenesis Calls for Unconventional Drugs To Fight Alzheimer’s Disease
DOI: 10.1021/acschemneuro.9b00676

Three-Dimensional Microfluidic Platform with Neural Organoids: Model System for Unraveling Synapses
DOI: 10.1021/acschemneuro.9b00654

NeuroChat with Professor P. Jeffrey Conn
DOI: 10.1021/acschemneuro.9b00567

The Brain Exposure Efficiency (BEE) Score
DOI: 10.1021/acschemneuro.9b00650

Tuning Properties for Blood–Brain Barrier Permeation: A Statistics-Based Analysis
DOI: 10.1021/acschemneuro.9b00541

ACS Combinatorial Science

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Beyond Epitope Binning: Directed in Vitro Selection of Complementary Pairs of Binding Proteins
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acscombsci.9b00176

Off-DNA DNA-Encoded Library Affinity Screening
DOI: 10.1021/acscombsci.9b00153

Oxidative Cyclization Approach to Benzimidazole Libraries
DOI: 10.1021/acscombsci.9b00189

One-Pot Synthesis of Unsymmetrical Bis-Heterocycles: Benzimidazole-, Benzoxazole-, and Benzothiazole-Linked Thiazolidines
DOI: 10.1021/acscombsci.9b00161

Rapid Characterization and Parameter Space Exploration of Perovskites Using an Automated Routine
DOI: 10.1021/acscombsci.9b00068

ACS Earth and Space Chemistry

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High-Resolution Gas Phase Spectroscopy of Molecules Desorbed from an Ice Surface: A Proof-of-Principle Study
DOI: 10.1021/acsearthspacechem.9b00246

Cloud Water Chemistry Associated with Urban Aerosols: Rapid Hydroxyl Radical Formation, Soluble Metals, Fe(II), Fe(III), and Quinones
DOI: 10.1021/acsearthspacechem.9b00243

The Labile Nature of Ice Nucleation by Arizona Test Dust
DOI: 10.1021/acsearthspacechem.9b00304

Mechanistic Study on Iron Solubility in Atmospheric Mineral Dust Aerosol: Roles of Titanium, Dissolved Oxygen, and Solar Flux in Solutions Containing Different Acid Anions
DOI: 10.1021/acsearthspacechem.9b00280

Processes Governing Chromium Contamination of Groundwater and Soil from a Chromium Waste Source
DOI: 10.1021/acsearthspacechem.9b00223

ACS Energy Letters

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Women Scientists at the Forefront of Energy Research: A Virtual Issue
DOI: 10.1021/acsenergylett.9b02695

Perovskite Photocatalysis. Methyl Viologen Induces Unusually Long-Lived Charge Carrier Separation in CsPbBr3 Nanocrystals
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsenergylett.9b02573

Addressing the Interfacial Properties for CO Electroreduction on Cu with Cyclic Voltammetry
DOI: 10.1021/acsenergylett.9b02456

Understanding Transformations in Battery Materials Using in Situ and Operando Experiments: Progress and Outlook
DOI: 10.1021/acsenergylett.9b02514

Energizing Energy-Innovations
DOI: 10.1021/acsenergylett.9b02717

ACS Infectious Diseases

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Setting Our Sights on Infectious Diseases
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.9b00371

Large-Scale Chemical-Genetic Strategy Enables the Design of Antimicrobial Combination Chemotherapy in Mycobacteria
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsinfecdis.9b00373

Rational Design of Doravirine: From Bench to Patients
DOI: 10.1021/acsinfecdis.9b00178

ACS Infectious Diseases Special Issue Focused on Gut Pathogens
DOI: 10.1021/acsinfecdis.9b00432

Signaling Natural Products from Human Pathogenic Bacteria
DOI: 10.1021/acsinfecdis.9b00286

ACS Macro Letters

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Polymerizations in Continuous Flow: Recent Advances in the Synthesis of Diverse Polymeric Materials
DOI: 10.1021/acsmacrolett.9b00933

Readily Degradable Aromatic Polyesters from Salicylic Acid
DOI: 10.1021/acsmacrolett.9b00890

Happy 100th Anniversary to Polymer Science and Engineering
DOI: 10.1021/acsmacrolett.9b01029

Architecture-Dependent Interplay between Self-Assembly and Crystallization in Discrete Block Co-Oligomers
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsmacrolett.9b00814

Semiconductor Quantum Dots Are Efficient and Recyclable Photocatalysts for Aqueous PET-RAFT Polymerization
DOI: 10.1021/acsmacrolett.9b00891

ACS Materials Letters

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Pentacyclic Ladder-Heteraborin Emitters Exhibiting High-Efficiency Blue Thermally Activated Delayed Fluorescence with an Ultrashort Emission Lifetime
DOI: 10.1021/acsmaterialslett.9b00433

MXetronics: MXene-Enabled Electronic and Photonic Devices
DOI: 10.1021/acsmaterialslett.9b00419

Controllable Water Vapor Assisted Chemical Vapor Transport Synthesis of WS2–MoS2 Heterostructure
DOI: 10.1021/acsmaterialslett.9b00415

Visible-Light-Assisted Gasochromic Sensing of Nicotine from Cigarette Smoke by Metal-Organic Nanotube
DOI: 10.1021/acsmaterialslett.9b00314

Formation of Supraparticles and Their Application in Catalysis
DOI: 10.1021/acsmaterialslett.9b00446

ACS Medicinal Chemistry Letters

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LogD Contributions of Substituents Commonly Used in Medicinal Chemistry
DOI: 10.1021/acsmedchemlett.9b00489

PROTAC-Mediated Degradation of KRAS Protein for Anticancer Therapeutics
DOI: 10.1021/acsmedchemlett.9b00584

Novel Methyl-aza-quinazolines as Inhibitors of the RAS-SOS Interaction
DOI: 10.1021/acsmedchemlett.9b00546

Modulation of RNA Splicing for the Treatment of Cancer
DOI: 10.1021/acsmedchemlett.9b00585

Novel Pyrazolyl-dihydroisoquinolines as Positive Allosteric Modulator of the Dopamine D1 Receptor
DOI: 10.1021/acsmedchemlett.9b00547

ACS Nano

Will Any Crap We Put into Graphene Increase Its Electrocatalytic Effect?
DOI: 10.1021/acsnano.9b00184

Big Nano Conversations
DOI: 10.1021/acsnano.0c00437

Present and Future of Surface-Enhanced Raman Scattering
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsnano.9b04224

In Nano, Volume 14, Issue 1
DOI: 10.1021/acsnano.0c00093

Antibacterial Liquid Metals: Biofilm Treatment via Magnetic Activation
DOI: 10.1021/acsnano.9b07861

ACS Omega

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Identification of Psychoactive Metabolites from Cannabis sativa, Its Smoke, and Other Phytocannabinoids Using Machine Learning and Multivariate Methods
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsomega.9b02663

Machine Learning in Catalysis, From Proposal to Practicing
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsomega.9b03673

Impact of Maleimide Disubstitution on Chemical and Biological Characteristics of HER2 Antibody–Drug Conjugates
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsomega.9b03510

Whole Exome and Transcriptome RNA-Sequencing Model for the Diagnosis of Prostate Cancer
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsomega.9b02995

Implications of Testing a Zinc–Oxygen Battery with Zinc Foil Anode Revealed by Operando Gas Analysis
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsomega.9b03224

ACS Photonics

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Sensitivity of Sub-Bandgap External Quantum Efficiency Measurements of Solar Cells under Electrical and Light Bias
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsphotonics.9b01531

Nighttime Photovoltaic Cells: Electrical Power Generation by Optically Coupling with Deep Space
DOI: 10.1021/acsphotonics.9b00679

Energy Transport in CsPbBr3 Perovskite Nanocrystal Solids
DOI: 10.1021/acsphotonics.9b01316

High Quality Factor Dielectric Metasurfaces for Ultraviolet Circular Dichroism Spectroscopy
DOI: 10.1021/acsphotonics.9b01352

Electrically Tunable Metasurface with Independent Frequency and Amplitude Modulations
DOI: 10.1021/acsphotonics.9b01532

ACS Sensors

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Nanoparticle Reservoirs for Paper-Only Immunosensors
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acssensors.9b01937

Natural Perspiration Sampling and in Situ Electrochemical Analysis with Hydrogel Micropatches for User-Identifiable and Wireless Chemo/Biosensing
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acssensors.9b01727

Happy 5th Anniversary for ACS Sensors
DOI: 10.1021/acssensors.0c00023

Rapid Analysis in Continuous-Flow Electrochemical Paper-Based Analytical Devices
DOI: 10.1021/acssensors.9b02298

Graphene Field Effect Transistor-Based Immunosensor for Ultrasensitive Noncompetitive Detection of Small Antigens
DOI: 10.1021/acssensors.9b02137

The ACS Style Guide

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Qualities of Effective Scholarly Communication
DOI: 10.1021/acsguide.10101

Introduction
DOI: 10.1021/acsguide.20301

Communicating Science to Your Peers
DOI: 10.1021/acsguide.10102

Introduction
DOI: 10.1021/acsguide.50201

Types of Intellectual Property
DOI: 10.1021/acsguide.10401

ACS Sustainable Chemistry & Engineering

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Debromination and Decomposition Mechanisms of Phenolic Resin Molecules in Ball Milling with Nano-Zerovalent Iron
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acssuschemeng.9b05071

Size-Dependent Uptake and Distribution of AgNPs by Silkworms
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acssuschemeng.9b05799

The Evolution of ACS Sustainable Chemistry & Engineering
DOI: 10.1021/acssuschemeng.9b07302

Highly Ordered Hierarchically Macroporous MIL-125 with High Specific Surface Area for Photocatalytic CO2 Fixation
DOI: 10.1021/acssuschemeng.9b04829

Biocatalytic Synthesis of Furan-Based Oligomer Diols with Enhanced End-Group Fidelity
Open Access Through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.9b05874

ACS Symposium Series

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Recent Development in Cathodic Catalyst towards Performance of Bioelectrochemical Systems
DOI: 10.1021/bk-2020-1342.ch001

Title, Copyright, Foreword
DOI: 10.1021/bk-2020-1342.fw001

Preface
DOI: 10.1021/bk-2020-1342.pr001

Novel Bioelectrocatalytic Strategies Based on Immobilized Redox Metalloenzymes on Tailored Electrodes
DOI: 10.1021/bk-2020-1342.ch010

Editors’ Biographies
DOI: 10.1021/bk-2020-1342.ot001

ACS Synthetic Biology

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Cell-Free Protein Synthesis as a Prototyping Platform for Mammalian Synthetic Biology
DOI: 10.1021/acssynbio.9b00437

Artificial Cells Capable of Long-Lived Protein Synthesis by Using Aptamer Grafted Polymer Hydrogel
DOI: 10.1021/acssynbio.9b00338

Design of Mammalian ON-Riboswitches Based on Tandemly Fused Aptamer and Ribozyme
Open Access Through ACS AuthorChoice
DOI: 10.1021/acssynbio.9b00371

Identification, Characterization, and Application of a Highly Sensitive Lactam Biosensor from Pseudomonas putida
DOI: 10.1021/acssynbio.9b00292

Point-of-Use Detection of Environmental Fluoride via a Cell-Free Riboswitch-Based Biosensor
DOI: 10.1021/acssynbio.9b00347

Analytical Chemistry

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Deep Learning for the Precise Peak Detection in High-Resolution LC–MS Data
DOI: 10.1021/acs.analchem.9b04811

2020 Reviews Issue
DOI: 10.1021/acs.analchem.9b05664

Predicting Breast Cancer by Paper Spray Ion Mobility Spectrometry Mass Spectrometry and Machine Learning
DOI: 10.1021/acs.analchem.9b03966

Signal Amplification in Living Cells: A Review of microRNA Detection and Imaging
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.analchem.9b04752

CRISPR/Cas13a Signal Amplification Linked Immunosorbent Assay for Femtomolar Protein Detection
DOI: 10.1021/acs.analchem.9b04403

Biochemistry

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Introducing “Future of Biochemistry 2020: The Asia-Pacific Issue”
DOI: 10.1021/acs.biochem.9b01113

Synaptic Copper, Amyloid-β, and Neurotransmitters in Alzheimer’s Disease
DOI: 10.1021/acs.biochem.9b00775

Decoding Principles of Selective GPCR-Gα Coupling
DOI: 10.1021/acs.biochem.9b00828

A Novel Epigenetic Mark Derived from Vitamin C
DOI: 10.1021/acs.biochem.9b00779

The Inside Story: Crystal Structure of the Chemokine Receptor CCR7 with an Intracellular Allosteric Antagonist
DOI: 10.1021/acs.biochem.9b00893

Bioconjugate Chemistry

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Site-Specific Conjugation of the Indolinobenzodiazepine DGN549 to Antibodies Affords Antibody–Drug Conjugates with an Improved Therapeutic Index as Compared with Lysine Conjugation
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.bioconjchem.9b00777

High Fidelity Suzuki–Miyaura Coupling for the Synthesis of DNA Encoded Libraries Enabled by Micelle Forming Surfactants
DOI: 10.1021/acs.bioconjchem.9b00838

Near-Infrared Photoimmunotherapy: Photoactivatable Antibody–Drug Conjugates (ADCs)
DOI: 10.1021/acs.bioconjchem.9b00546

Development of Near-Infrared Fluorescent Probes for Use in Alzheimer’s Disease Diagnosis
DOI: 10.1021/acs.bioconjchem.9b00695

Fluorogen-Activating Proteins: Next-Generation Fluorescence Probes for Biological Research
DOI: 10.1021/acs.bioconjchem.9b00710

Biomacromolecules

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Future of Biomacromolecules at a Crossroads of Polymer Science and Biology
DOI: 10.1021/acs.biomac.9b01536

Structural Studies Using Unnatural Oligosaccharides: Toward Sugar Foldamers
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b01090

Polyampholytes as Emerging Macromolecular Cryoprotectants
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b01053

Nanomaterials Derived from Fungal Sources—Is It the New Hype?
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b01141

Tailoring Polymersome Shape Using the Hofmeister Effect
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.biomac.9b00924

C&EN Global Enterprise

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A love affair with chemistry
DOI: 10.1021/cen-09801-cover

The new drugs of 2019
DOI: 10.1021/cen-09803-cover

2020 Cope and Cope Scholar Award winners
DOI: 10.1021/cen-09802-awards

A greener alternative to Wittig
DOI: 10.1021/cen-09802-scicon5

C&EN’s World Chemical Outlook 2020
DOI: 10.1021/cen-09802-cover1

Chemical Research in Toxicology

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Cardiovascular Toxicity Induced by Kinase Inhibitors: Mechanisms and Preclinical Approaches
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.chemrestox.9b00387

Use of Zebrafish in Drug Discovery Toxicology
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.chemrestox.9b00335

Chemical Toxicology and Medicinal Chemistry: A Special Issue Promoting Scientific Advances for Safer Medicines, Part 1
DOI: 10.1021/acs.chemrestox.9b00496

Quantitative Systems Toxicology Modeling To Address Key Safety Questions in Drug Development: A Focus of the TransQST Consortium
DOI: 10.1021/acs.chemrestox.9b00499

Letter to the Editor Regarding the Article Rotenone Increases Isoniazid Toxicity but Does Not Cause Significant Liver Injury: Implications for the Hypothesis that Inhibition of the Mitochondrial Electron Transport Chain Is a Common Mechanism of Idiosyncratic Drug-Induced Liver Injury by Cho and Co-Workers, 2019
DOI: 10.1021/acs.chemrestox.9b00416

Chemical Reviews

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Introduction: Molecular Motors
DOI: 10.1021/acs.chemrev.9b00819

Photo- and Redox-Driven Artificial Molecular Motors
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.chemrev.9b00291

Design of Collective Motions from Synthetic Molecular Switches, Rotors, and Motors
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.chemrev.9b00288

Importance of Size and Contact Structure of Gold Nanoparticles for the Genesis of Unique Catalytic Processes
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.chemrev.9b00551

Light-Activated Organic Molecular Motors and Their Applications
DOI: 10.1021/acs.chemrev.9b00221

Chemistry of Materials

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What Papers Were of the Greatest Interest to Our Readers in 2019? The Top 20 Downloads of the Year
DOI: 10.1021/acs.chemmater.9b05302

Locating and Controlling the Zn Content in In(Zn)P Quantum Dots
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.chemmater.9b04407

Self-Assembly of Chiral Nanoparticles into Semiconductor Helices with Tunable near-Infrared Optical Activity
DOI: 10.1021/acs.chemmater.9b04143

Fractal-in-a-Sphere: Confined Self-Assembly of Fractal Silica Nanoparticles
DOI: 10.1021/acs.chemmater.9b03864

Toward New 2D Zirconium-Based Metal–Organic Frameworks: Synthesis, Structures, and Electronic Properties
DOI: 10.1021/acs.chemmater.9b02462

Crystal Growth & Design

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Celebrating 20 Years
DOI: 10.1021/acs.cgd.9b01576

Real-Time in Situ Monitoring of Particle and Structure Evolution in the Mechanochemical Synthesis of UiO-66 Metal–Organic Frameworks
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.cgd.9b01477

Kinetics of Crystallization and Glass Transition in Amorphous Materials
DOI: 10.1021/acs.cgd.9b00651

Semiconductor Cocrystals Based on Boron: Generated Electrical Response with π-Rich Aromatic Molecules
DOI: 10.1021/acs.cgd.9b00953

Crystallization of Sulfathiazole in Gel: Polymorph Selectivity and Cross-Nucleation
DOI: 10.1021/acs.cgd.9b00990

Energy & Fuels

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Asphaltenes: Definition, Properties, and Reactions of Model Compounds
DOI: 10.1021/acs.energyfuels.9b03291

Combining Image Recognition and Simulation To Reproduce the Adsorption/Desorption Behaviors of Shale Gas
DOI: 10.1021/acs.energyfuels.9b03669

High-Purity Vanadyl Petroporphyrins: Their Aggregation and Effect on the Aggregation of Asphaltenes
DOI: 10.1021/acs.energyfuels.9b03237

A Review on Wettability Alteration in Carbonate Rocks: Wettability Modifiers
DOI: 10.1021/acs.energyfuels.9b03409

A New Method for Pore Structure Quantification and Pore Network Extraction from SEM Images
DOI: 10.1021/acs.energyfuels.9b02522

Environmental Science & Technology

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Could We Spare a Moment of the Spotlight for Persistent, Water-Soluble Polymers?
DOI: 10.1021/acs.est.9b07089

Formation of a U(VI)–Persulfide Complex during Environmentally Relevant Sulfidation of Iron (Oxyhydr)oxides
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.est.9b03180

Should Monitoring of Molybdenum (Mo) in Groundwater, Drinking Water and Well Permitting Made Mandatory?
DOI: 10.1021/acs.est.9b06869

Selective Phosphate Removal from Water and Wastewater using Sorption: Process Fundamentals and Removal Mechanisms
DOI: 10.1021/acs.est.9b05569

Post Dioxin Period for Feed: Cocktail Effects of Emerging POPs and Analogues
DOI: 10.1021/acs.est.9b07160

Environmental Science & Technology Letters

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Water Harvesting from the Atmosphere in Arid Areas with Manganese Dioxide
DOI: 10.1021/acs.estlett.9b00713

Submicrometer PM1.0 Exposure from Household Burning of Solid Fuels
DOI: 10.1021/acs.estlett.9b00633

Perturbation of Normal Algal Growth by Black Phosphorus Nanosheets: The Role of Degradation
DOI: 10.1021/acs.estlett.9b00726

Predicting Abiotic Reduction Rates Using Cryogenically Collected Soil Cores and Mediated Reduction Potential Measurements
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.estlett.9b00665

Novel High Molecular Weight Synthetic Phenolic Antioxidants in Indoor Dust in Toronto, Canada
DOI: 10.1021/acs.estlett.9b00715

Industrial & Engineering Chemistry Research

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A Review on Lignin Liquefaction: Advanced Characterization of Structure and Microkinetic Modeling
DOI: 10.1021/acs.iecr.9b05744

Magnetite as Inorganic Hole Transport Material for Lead Halide Perovskite-Based Solar Cells with Enhanced Stability
DOI: 10.1021/acs.iecr.9b05173

Method To Synthesize Micronized Spherical Carbon Particles from Lignin
DOI: 10.1021/acs.iecr.9b05143

Metal Organic Framework Functionalized Fabrics for Detoxification of Chemical Warfare Agents
DOI: 10.1021/acs.iecr.9b06695

Process Designs for Converting Propylene Glycol to Acrylic Acid via Lactic Acid and Allyl Alcohol
Open Access Through AuthorChoice
DOI: 10.1021/acs.iecr.9b04334

Inorganic Chemistry

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Innovative f-Element Chelating Strategies
DOI: 10.1021/acs.inorgchem.9b03583

Youthful Exuberance
DOI: 10.1021/acs.inorgchem.9b03599

A Ketimide-Stabilized Palladium Nanocluster with a Hexagonal Aromatic Pd7 Core
DOI: 10.1021/acs.inorgchem.9b03276

Ligand Field Theory and Angular Overlap Model Based Analysis of the Electronic Structure of Homovalent Iron–Sulfur Dimers
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.inorgchem.9b00974

Metal Complexes for Catalytic Polymerizations
DOI: 10.1021/acs.inorgchem.9b03531

Journal of Agricultural and Food Chemistry

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Effects of Hop Bitter Acids, Bitter Components in Beer, on Cognition in Healthy Adults: A Randomized Controlled Trial
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jafc.9b06660

Nondigestible Oligosaccharides with Anti-Obesity Effects
DOI: 10.1021/acs.jafc.9b06079

Rebuttal to the Comment on Metabolomics for a Millenniums-Old Crop: Tea Plant (Camellia sinensis)
DOI: 10.1021/acs.jafc.9b07082

We Are All JAFC. Thanks for Your Engagement!
DOI: 10.1021/acs.jafc.9b07943

Consumption of a Natural High-Intensity Sweetener Enhances Activity and Expression of Rabbit Intestinal Na+/Glucose Cotransporter 1 (SGLT1) and Improves Colibacillosis-Induced Enteric Disorders
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jafc.9b04995

Journal of Chemical & Engineering Data

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Phase Equilibrium of Carbon Dioxide Hydrates Inhibited with MEG and NaCl above the Upper Quadruple Point
DOI: 10.1021/acs.jced.9b01001

Experimental and Thermodynamic Modeling Study of the Quaternary System Containing Lithium, Potassium, Magnesium, and Sulfate at 288.15 K
DOI: 10.1021/acs.jced.9b00731

Determination and Correlation of the Solubility of Sodium Naphthalene-1,5-disulfonate in Five Pure Solvents and Three Binary Solvent Systems at the Temperature Range from 283.15 to 323.15 K
DOI: 10.1021/acs.jced.9b00029

Thermodynamic Modeling of Aqueous Two-Phase Systems Composed of Macromolecules and Sulfate Salts at pH 2.0
DOI: 10.1021/acs.jced.9b00557

Liquid–Liquid Equilibria of Ternary Mixtures (1-Heptanol, Propanone, 2-Butanone or 2-Heptanone + γ-Valerolactone + n-Tetradecane)
DOI: 10.1021/acs.jced.9b00590

Journal of Chemical Education

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“Hello, I Must Be Going”
DOI: 10.1021/acs.jchemed.9b01147

SweepStat: A Build-It-Yourself, Two-Electrode Potentiostat for Macroelectrode and Ultramicroelectrode Studies
DOI: 10.1021/acs.jchemed.9b00893

Basics of Fourier Transform Applied to NMR Spectroscopy: An Interactive Open-Source Web Application
DOI: 10.1021/acs.jchemed.9b00502

Problem-Solving Behaviors of Different Achievement Groups on Multiple-Choice Questions in General Chemistry
DOI: 10.1021/acs.jchemed.9b00774

Investing in Laboratory Courses
DOI: 10.1021/acs.jchemed.9b00714

Journal of Chemical Information and Modeling

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Novel Directions in Free Energy Methods and Applications
DOI: 10.1021/acs.jcim.9b01174

Off-Pocket Activity Cliffs: A Puzzling Facet of Molecular Recognition
DOI: 10.1021/acs.jcim.9b00731

DeepScaffold: A Comprehensive Tool for Scaffold-Based De Novo Drug Discovery Using Deep Learning
DOI: 10.1021/acs.jcim.9b00727

Molecular Generative Model Based on an Adversarially Regularized Autoencoder
DOI: 10.1021/acs.jcim.9b00694

Graph Convolutional Neural Networks as “General-Purpose” Property Predictors: The Universality and Limits of Applicability
DOI: 10.1021/acs.jcim.9b00587

Journal of Chemical Theory and Computation

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Automating the Development of High-Dimensional Reactive Potential Energy Surfaces with the robosurfer Program System
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b01006

Hierarchical Ensembles of Intrinsically Disordered Proteins at Atomic Resolution in Molecular Dynamics Simulations
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00809

Efficient Implementation of Ab Initio Quantum Embedding in Periodic Systems: Density Matrix Embedding Theory
DOI: 10.1021/acs.jctc.9b00933

Computing Spatially Resolved Rotational Hydration Entropies from Atomistic Simulations
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.9b00926

Machine Learning-Guided Approach for Studying Solvation Environments
DOI: 10.1021/acs.jctc.9b00605

Journal of Medicinal Chemistry

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Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
DOI: 10.1021/acs.jmedchem.9b01180

Design, Synthesis, and Biological Evaluation of MEK PROTACs
DOI: 10.1021/acs.jmedchem.9b00810

Ligand-Based Design of Allosteric Retinoic Acid Receptor-Related Orphan Receptor γt (RORγt) Inverse Agonists
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jmedchem.9b01372

Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria
DOI: 10.1021/acs.jmedchem.9b01604

Discovery of 6-(2,4-Dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid (SAR439859), a Potent and Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen-Receptor-Positive Breast Cancer
DOI: 10.1021/acs.jmedchem.9b01293

Journal of Natural Products

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A Change in Editor-in-Chief and a New Look
DOI: 10.1021/acs.jnatprod.0c00004

Synthesis of [3,3-2H2]-Dihydroartemisinic Acid to Measure the Rate of Nonenzymatic Conversion of Dihydroartemisinic Acid to Artemisinin
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jnatprod.9b00686

Schwarzinicines A–G, 1,4-Diarylbutanoid–Phenethylamine Conjugates from the Leaves of Ficus schwarzii
DOI: 10.1021/acs.jnatprod.9b01160

Isopimarane Diterpenoids from the Rhizomes of Kaempferia marginata and Their Potential Anti-inflammatory Activities
DOI: 10.1021/acs.jnatprod.9b00307

The First Racemic Total Syntheses of the Antiplasmodials Watsonianones A and B and Corymbone B
DOI: 10.1021/acs.jnatprod.8b01077

The Journal of Organic Chemistry

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Retraction of “Oxone-Mediated Oxidative Cleavage of β-Keto Esters and 1,3-Diketones to α-Keto Esters and 1,2-Diketones in Aqueous Medium”
DOI: 10.1021/acs.joc.9b03422

Editorial for the Special Issue on Functional Organic Materials
DOI: 10.1021/acs.joc.9b03249

A Quest for Structurally Uniform Graphene Nanoribbons: Synthesis, Properties, and Applications
DOI: 10.1021/acs.joc.9b02814

Visible Light-Promoted Phosphine-Catalyzed Difluoroalkylation of Arenes and Heterocycles
DOI: 10.1021/acs.joc.9b02882

Brønsted Acid Catalyzed Peterson Olefinations
DOI: 10.1021/acs.joc.9b02489

The Journal of Physical Chemistry A

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Non-condon Effect on Ultrafast Excited-State Intramolecular Proton Transfer
DOI: 10.1021/acs.jpca.9b09085

Comprehensive Benchmark Results for the Domain Based Local Pair Natural Orbital Coupled Cluster Method (DLPNO-CCSD(T)) for Closed- and Open-Shell Systems
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpca.9b05734

A New Editor-in-Chief for The Journal of Physical Chemistry
DOI: 10.1021/acs.jpca.9b11480

Session Viewpoints on the 2019 International Symposium on Free Radicals Conference
DOI: 10.1021/acs.jpca.9b11797

Carboxylic Sulfuric Anhydrides
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jpca.9b09310

The Journal of Physical Chemistry B

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Modeling DNA Flexibility: Comparison of Force Fields from Atomistic to Multiscale Levels
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jpcb.9b09106

Analysis of Self-Assembly Pathways with Unsupervised Machine Learning Algorithms
DOI: 10.1021/acs.jpcb.9b09621

Role of Intrinsically Disordered Regions in Acceleration of Protein–Protein Association
DOI: 10.1021/acs.jpcb.9b08793

Ion Binding and Selectivity of the Na+/H+ Antiporter MjNhaP1 from Experiment and Simulation
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.9b08552

A Proton Wire Mediates Proton Coupled Electron Transfer from Hydroxyurea and Other Hydroxamic Acids to Tyrosyl Radical in Class Ia Ribonucleotide Reductase
DOI: 10.1021/acs.jpcb.9b08587

The Journal of Physical Chemistry C

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Entropy Changes upon Double Layer Charging at a (111)-Textured Au Film in Pure 1-Butyl-1-Methylpyrrolidinium Bis[(trifluoromethyl)sulfonyl]imide Ionic Liquid
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jpcc.9b09871

A New Editor-in-Chief for The Journal of Physical Chemistry
DOI: 10.1021/acs.jpcc.9b11478

Temperature Discontinuity at an Evaporating Water Interface
DOI: 10.1021/acs.jpcc.9b10838

Iron Complex as a Water-Oxidizing Catalyst: Free-Energy Barriers, Proton-Coupled Electron Transfer, Spin Dynamics, and Role of Water Molecules in the Reaction Mechanism
DOI: 10.1021/acs.jpcc.9b10378

Bifunctional Nickel–Nitrogen-Doped-Carbon-Supported Copper Electrocatalyst for CO2 Reduction
DOI: 10.1021/acs.jpcc.9b08931

The Journal of Physical Chemistry Letters

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Stability of Lead and Tin Halide Perovskites: The Link between Defects and Degradation
DOI: 10.1021/acs.jpclett.9b02191

JPCL: A New Era
DOI: 10.1021/acs.jpclett.9b03765

Observation of Nonradiative Deactivation Behavior from Singlet and Triplet States of Thermally Activated Delayed Fluorescence Emitters in Solution
DOI: 10.1021/acs.jpclett.9b03302

The Cost of Converting Excitons into Free Charge Carriers in Organic Solar Cells
DOI: 10.1021/acs.jpclett.9b02719

Monitoring Charge Carrier Diffusion across a Perovskite Film with Transient Absorption Spectroscopy
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.9b03427

Journal of Proteome Research

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Changes to the TDP-43 and FUS Interactomes Induced by DNA Damage
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jproteome.9b00575

Optimized Workflow for Multiplexed Phosphorylation Analysis of TMT-Labeled Peptides Using High-Field Asymmetric Waveform Ion Mobility Spectrometry
DOI: 10.1021/acs.jproteome.9b00759

Mass Spectrometry-Compatible Subcellular Fractionation for Proteomics
DOI: 10.1021/acs.jproteome.9b00347

A Serial Sample Processing Strategy with Improved Performance for in-Depth Quantitative Analysis of Type III Secretion Events in Pseudomonas aeruginosa
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jproteome.9b00628

Global Secretome Characterization of the Pathogenic Yeast Candida glabrata
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jproteome.9b00299

Journal of the American Chemical Society

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Decarbonylative Olefination of Aldehydes to Alkenes
DOI: 10.1021/jacs.9b12354

Synthesis of Sterically Hindered Primary Amines by Concurrent Tandem Photoredox Catalysis
DOI: 10.1021/jacs.9b10871

A Nanovessel-Catalyzed Three-Component Aza-Darzens Reaction
DOI: 10.1021/jacs.9b13177

Silyl Radical-Mediated Activation of Sulfamoyl Chlorides Enables Direct Access to Aliphatic Sulfonamides from Alkenes
DOI: 10.1021/jacs.9b13071

Spotlights on Recent JACS Publications
DOI: 10.1021/jacs.0c00203

Journal of the American Society for Mass Spectrometry

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To Improve Is To Change···Again
DOI: 10.1021/jasms.9b00126

Enhancing Protein Electrospray Charge States by Multivalent Metal Ions: Mechanistic Insights from MD Simulations and Mass Spectrometry Experiments
DOI: 10.1021/jasms.9b00027

Role of Chemical Dynamics Simulations in Mass Spectrometry Studies of Collision-Induced Dissociation and Collisions of Biological Ions with Organic Surfaces
DOI: 10.1021/jasms.9b00062

LipostarMSI: Comprehensive, Vendor-Neutral Software for Visualization, Data Analysis, and Automated Molecular Identification in Mass Spectrometry Imaging
DOI: 10.1021/jasms.9b00034

Implementation of a Charge-Sensitive Amplifier without a Feedback Resistor for Charge Detection Mass Spectrometry Reduces Noise and Enables Detection of Individual Ions Carrying a Single Charge
DOI: 10.1021/jasms.9b00010

Langmuir

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Pattern Formation in Precipitation Reactions: The Liesegang Phenomenon
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.langmuir.9b03018

Microsuspension Polymerization of Styrene Using Cellulose Nanocrystals as Pickering Emulsifiers: On the Evolution of Latex Particles
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.langmuir.9b03583

New Directions for Langmuir
DOI: 10.1021/acs.langmuir.9b03781

Recent Highlights on Interfaces from India: A Virtual Issue
DOI: 10.1021/acs.langmuir.9b03750

Experimental Evidence for Algebraic Double-Layer Forces
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.langmuir.9b03077

Macromolecules

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Block Copolymers: Long-Term Growth with Added Value
DOI: 10.1021/acs.macromol.9b02069

Inputs of Macromolecular Engineering in the Design of Injectable Hydrogels Based on Synthetic Thermoresponsive Polymers
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.macromol.9b00705

Discovery of the RAFT Process and Its Impact on Radical Polymerization
DOI: 10.1021/acs.macromol.9b02054

Editorial
DOI: 10.1021/acs.macromol.9b02714

Phosphorus- and Sulfur-Containing High-Refractive-Index Polymers with High Tg and Transparency Derived from a Bio-Based Aldehyde
DOI: 10.1021/acs.macromol.9b01770

Molecular Pharmaceutics

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Practical Approach to Modeling the Impact of Amorphous Drug Nanoparticles on the Oral Absorption of Poorly Soluble Drugs
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00889

Antibody–Drug Conjugates with Indolinobenzodiazepine Dimer Payloads: DNA-Binding Mechanism of Indolinobenzodiazepine Dimer Catabolites in Target Cancer Cells
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.9b00675

Evaluation of an Integrin αvβ3 and Aminopeptidase N Dual-Receptor Targeting Tracer for Breast Cancer Imaging
DOI: 10.1021/acs.molpharmaceut.9b01134

Molecular Interpretation of the Compaction Performance and Mechanical Properties of Caffeine Cocrystals: A Polymorphic Study
DOI: 10.1021/acs.molpharmaceut.9b00377

A Brain Penetrating Bifunctional Erythropoietin-Transferrin Receptor Antibody Fusion Protein for Alzheimer’s Disease
DOI: 10.1021/acs.molpharmaceut.9b01211

Nano Letters

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Layer-by-Layer Growth of Complex-Shaped Three-Dimensional Nanostructures with Focused Electron Beams
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.nanolett.9b03565

Nano Letters 2020
DOI: 10.1021/acs.nanolett.9b05084

Machine Learning in Nanoscience: Big Data at Small Scales
DOI: 10.1021/acs.nanolett.9b04090

Bioengineering Bacterial Vesicle-Coated Polymeric Nanomedicine for Enhanced Cancer Immunotherapy and Metastasis Prevention
DOI: 10.1021/acs.nanolett.9b02182

A Reconfigurable Remotely Epitaxial VO2 Electrical Heterostructure
DOI: 10.1021/acs.nanolett.9b02696

Organic Letters

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Reductive sp3–sp2 Coupling Reactions Enable Late-Stage Modification of Pharmaceuticals
DOI: 10.1021/acs.orglett.9b04320

2019: A Tremendous Year for Organic Letters
DOI: 10.1021/acs.orglett.9b04640

Five-Step Synthesis of Yaequinolones J1 and J2
DOI: 10.1021/acs.orglett.9b04455

Site-Selective C–H Alkylation of Piperazine Substrates via Organic Photoredox Catalysis
DOI: 10.1021/acs.orglett.9b04456

Nickel-Catalyzed Asymmetric Hydrocyanation of Allenes
DOI: 10.1021/acs.orglett.9b03938

Organic Process Research & Development

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A Versatile Method of Ambient-Temperature Solvent Removal
DOI: 10.1021/acs.oprd.9b00368

Some Items of Interest to Process R&D Chemists and Engineers
DOI: 10.1021/acs.oprd.0c00003

Control Strategy Expectations in Early Clinical Phase Synthetic Oncology Programs: Two Global Regulatory Case Studies
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.oprd.9b00479

Thermal Stability and Explosive Hazard Assessment of Diazo Compounds and Diazo Transfer Reagents
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.oprd.9b00422

Regulatory Highlights
DOI: 10.1021/acs.oprd.9b00535

Organometallics

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Oxidatively Induced Aryl–CF3 Coupling at Diphosphine Nickel Complexes
DOI: 10.1021/acs.organomet.9b00678

2020 Vision: A Year for Pioneers and Influencers of Organometallic Chemistry
DOI: 10.1021/acs.organomet.9b00825

Redox Character and Small Molecule Reactivity of a Masked Titanium(II) Synthon
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.organomet.9b00637

Direct Observation of Transmetalation from a Neutral Boronate Ester to a Pyridine(diimine) Iron Alkoxide
DOI: 10.1021/acs.organomet.9b00733

Synthesis of an Air-Stable Pd(0) Catalyst Bearing Donor and Acceptor Phosphine Ligands
DOI: 10.1021/acs.organomet.9b00646

Founded in 2013 by the ACS Division of Inorganic Chemistry and Inorganic Chemistry, the annual Inorganic Chemistry Lectureship Award recognizes individuals who have demonstrated creativity and impact in the field of inorganic chemistry.

Meet the 2020 Inorganic Chemistry Lectureship Award Recipient

This year’s recipient is Professor Eric J. Schelter from the University of Pennsylvania. Professor Schelter is receiving the award for the development of methodologies related to rare-earth element separations and elucidation of the electronic structures of f-block complexes. His research aims to address the problems associated with recycling heavy-duty batteries and electronics.

Learn more about Professor Eric J. Schelter’s work in this exclusive interview:

What does this award mean to you?

I am thrilled to receive this award! I’m very proud of my research group and all they have accomplished in the past 10 years. Inorganic Chemistry is also a special journal for me because it was the venue where I published work from my undergraduate research with Professor Rudy Luck at Michigan Tech. And I also published the first paper from my graduate work with Professor Kim Dunbar, TAMU, in the journal. These were major career milestones and really helped to set my course. IC is the cornerstone journal of the field so, it is a tremendous honor – especially considering the previous recipients!

What prompted your work in this area?

I was drawn into the fascinating area of synthetic f-element chemistry as a postdoc at Los Alamos National Lab, working with Drs. Jackie Kiplinger, Kevin John, and Joe Thompson. I came to realize (and maintain!) that it was a field with opportunities to explore both fundamental- and applied chemical problems. It is also a great community of researchers! Beginning at Penn in 2009 my group started working on rare earths and uranium chemistry, looking at fundamental problems in redox and electronic structure. The emergence of the rare earths supply crisis in 2009-2010 drew us into practical and environmental aspects of the materials supply chain for those elements and got us thinking about new and fundamental chemistries that contribute to separating and recycling rare earths and other critical metals.

What will you be working on next?

My group and I are excited to continue expanding fundamental f-element chemistry, and to apply it in new areas! In addition to growing f-element separations methodologies in new ways, we are also expanding our separations chemistry to d-block targets through efforts in the Center for Sustainable Separations of Metals, an NSF CCI. We recently started working on some new molecular materials chemistry to develop emergent quantum properties underpinned by f-electrons. We’re continuing to study the unique, exciting reactivity of f-element-ligand multiple bonds. And we’re also interested in modeling the active site of a recently-discovered, natural, rare earth metal-containing metalloenzyme. Finally, we’re expanding our exploration of the unique properties of cerium compounds as photosensitizers and applying them in catalytic transformations. There are so many exciting opportunities in f-element chemistry!

Access Professor Schelter’s articles published in Inorganic Chemistry

Stay Tuned!

Stay tuned for more details on the symposium and the 2021 Award nominations process by subscribing to journal updates and alerts.

Explore some highlights of The Journal of Physical Chemistry A/B/C and The Journal of Physical Chemistry Letters from the last few months, including the most-read articles, featured articles, ACS Editors’ Choice articles, and articles from Special Issues.

Get the latest research sent straight to your inbox with journal e-alerts.

Welcoming Joan-Emma Shea and Gregory D. Scholes

ACS Publications is pleased to introduce Joan-Emma Shea as The Journal of Physical Chemistry A/B/C’s new Editor-in-Chief and Gregory D. Scholes as Editor-in-Chief for The Journal of Physical Chemistry Letters.

Read their Editorials to learn more about their plans for the journals:

A New Editor-in-Chief for The Journal of Physical Chemistry

Joan-Emma Shea

DOI: 10.1021/acs.jpca.9b11480

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JPCL: A New Era

Gregory D. Scholes

DOI: 10.1021/acs.jpclett.9b03765

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The Journal of Physical Chemistry A

Stay up-to-date with the latest articles: sign up for JPC A e-alerts

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Carboxylic Sulfuric Anhydrides

DOI: 10.1021/acs.jpca.9b09310

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Nonadiabatic Molecular Dynamics at Metal Surfaces

DOI: 10.1021/acs.jpca.9b10698

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Exploring the Forces Contributing to Noncovalent Bonding by Microwave Spectroscopy and Structural Characterization of Gas-Phase Heterodimers of Protic Acids with Haloethylenes

DOI: 10.1021/acs.jpca.9b07960

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Activation Energies and Beyond

DOI: 10.1021/acs.jpca.9b03967

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Catalytic CO Oxidation by Gas-Phase Metal Oxide Clusters

DOI: 10.1021/acs.jpca.9b05185

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Electronic Communication as a Transferable Property of Molecular Bridges?

DOI: 10.1021/acs.jpca.9b05618

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High Precision Electronic Spectroscopy of Ligand-Protected Gold Nanoclusters: Effects of Composition, Environment, and Ligand Chemistry

DOI: 10.1021/acs.jpca.9b09164

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Hydrogen-Bonding Mediated Reactions of Criegee Intermediates in the Gas Phase: Competition between Bimolecular and Termolecular Reactions and the Catalytic Role of Water

DOI: 10.1021/acs.jpca.9b07117

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The Journal of Physical Chemistry B

Stay up-to-date with the latest articles: sign up for JPC B e-alerts

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Proteins: “Boil ’Em, Mash ’Em, Stick ’Em in a Stew”

DOI: 10.1021/acs.jpcb.9b05467

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Physical Chemistry of Epigenetics: Single-Molecule Investigations

DOI: 10.1021/acs.jpcb.9b06214

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Energy Transport across Interfaces in Biomolecular Systems

DOI: 10.1021/acs.jpcb.9b07086

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Halogen Bonding beyond Crystals in Materials Science

DOI: 10.1021/acs.jpcb.9b07035

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How Does a Microbial Rhodopsin RxR Realize Its Exceptionally High Thermostability with the Proton-Pumping Function Being Retained?

DOI: 10.1021/acs.jpcb.9b10700

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Modeling DNA Flexibility: Comparison of Force Fields from Atomistic to Multiscale Levels

DOI: 10.1021/acs.jpcb.9b09106

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The Journal of Physical Chemistry C

Stay up-to-date with the latest articles: sign up for JPC C e-alerts

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Temperature Discontinuity at an Evaporating Water Interface

DOI: 10.1021/acs.jpcc.9b10838

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Phonon Dynamics in Anisotropic Dilute CuAl1–xFexO2 Delafossite Alloys by a Weighted Dynamical Matrix Approach

DOI: 10.1021/acs.jpcc.9b09402

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Iron Complex as a Water-Oxidizing Catalyst: Free-Energy Barriers, Proton-Coupled Electron Transfer, Spin Dynamics, and Role of Water Molecules in the Reaction Mechanism

DOI: 10.1021/acs.jpcc.9b10378

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Internal Atomic-Scale Structure Determination and Band Alignment of II–VI Quantum Dot Heterostructures

DOI: 10.1021/acs.jpcc.9b11443

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Entropy Changes upon Double Layer Charging at a (111)-Textured Au Film in Pure 1-Butyl-1-Methylpyrrolidinium Bis[(trifluoromethyl)sulfonyl]imide Ionic Liquid

DOI: 10.1021/acs.jpcc.9b09871

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Symmetry-Adapted High Dimensional Neural Network Representation of Electronic Friction Tensor of Adsorbates on Metals

DOI: 10.1021/acs.jpcc.9b09965

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Propagating DFT Uncertainty to Mechanism Determination, Degree of Rate Control, and Coverage Analysis: The Kinetics of Dry Reforming of Methane

DOI:10.1021/acs.jpcc.9b08755

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X-ray Spectroscopy of Silver Nanostructures toward Antibacterial Applications

DOI: 10.1021/acs.jpcc.9b09548

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Photothermalization and Hot Electron Dynamics in the Steady State

DOI: 10.1021/acs.jpcc.9b08916

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The Journal of Physical Chemistry Letters

Stay up-to-date with the latest articles: sign up for JPC Letters e-alert

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Stability of Lead and Tin Halide Perovskites: The Link between Defects and Degradation

DOI: 10.1021/acs.jpclett.9b02191

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Singlet Fission in Crystalline Organic Materials: Recent Insights and Future Directions

DOI: 10.1021/acs.jpclett.9b00754

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Charge Scaling Manifesto: A Way of Reconciling the Inherently Macroscopic and Microscopic Natures of Molecular Simulations

DOI: 10.1021/acs.jpclett.9b02652

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Metal-Free Deep Eutectic Solvents: Preparation, Physical Properties, and Significance

DOI: 10.1021/acs.jpclett.9b01980

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First-Principles Modeling of Electronic Stopping in Complex Matter under Ion Irradiation

DOI: 10.1021/acs.jpclett.9b02975

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Stability of Lead and Tin Halide Perovskites: The Link between Defects and Degradation

DOI: 10.1021/acs.jpclett.9b02191

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Singlet Fission in Crystalline Organic Materials: Recent Insights and Future Directions

DOI: 10.1021/acs.jpclett.9b00754

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Recent Virtual and Special Issues

Astrochemistry: From the Chemical Laboratory to the Stars

Hai-Lung Dai Festschrift

Leo Radom Festschrift

Hanna Reisler Festschrift

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This week: Sustainable Living Filtration Membranes — and more!

Each and every day, ACS grants free access to a new peer-reviewed research article from one of the Society’s journals. These articles are specially chosen by a team of scientific editors of ACS journals from around the world to highlight the transformative power of chemistry. Access to these articles will remain open to all as a public service.

Check out this week’s picks!
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Sustainable Living Filtration Membranes

Environ. Sci. Technol. Lett. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acs.estlett.0c00019
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An Amphiphilic Polymer-Supported Strategy Enables Chemical Transformations under Anhydrous Conditions for DNA-Encoded Library Synthesis

ACS Comb. Sci. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acscombsci.9b00164
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libmolgrid: Graphics Processing Unit Accelerated Molecular Gridding for Deep Learning Applications

J. Chem. Inf. Model. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acs.jcim.9b01145
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Increasing Poly(ethylene oxide) Stability to 4.5 V by Surface Coating of the Cathode

ACS Energy Lett. 2020, 5, XXX, 826-832
DOI: 10.1021/acsenergylett.9b02739
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Current Challenges and Routes Forward for Nonaqueous Lithium–Air Batteries

Chem. Rev. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acs.chemrev.9b00545
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Design and Combinatorial Development of Shield-1 Peptide Mimetics Binding to Destabilized FKBP12

ACS Comb. Sci. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acscombsci.9b00197
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A Generalized Variational Principle with Applications to Excited State Mean Field Theory

J. Chem. Theory Comput. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acs.jctc.9b01105
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Love ACS Editors’ Choice? Get a weekly e-mail of the latest ACS Editor’s Choice articles and never miss a breakthrough!

Reviewers of ACS Publications journal articles can now receive public acknowledgment of their work, thanks to a new collaboration with ORCID (Open Researcher and Contributor ID). Reviewers will be able to get credit through their ORCID profile, without revealing which article they’ve reviewed. This change will be especially helpful to young scientists looking to establish their credentials and it will allow all reviewers to present a more complete record of their contributions to science.

Reviewers are essential to scientific publishing. Their work helps both authors and editors, improving manuscripts and making recommendations about acceptance to journal editors. Without them, ACS Publications journals could not maintain their high editorial standards. Yet their contributions are often overlooked since reviewers must work anonymously to ensure that they can evaluate a manuscript impartially. Under this new deal, reviewers will receive the recognition they deserve, while preserving their anonymity.

ORCID is an open registry that assigns a unique identifier to every researcher, eliminating the confusion caused by researchers who happen to have the same name and increasing transparency in the publications process. ORCID makes it easier for readers to find a specific author while also making it easier for authors— and now reviewers— to get the credit they deserve. ORCID launched in 2012 and ACS signed the ORCID Open Letter in 2016, committing to requiring ORCID IDs for authors in all ACS Publications journals.

Learn More About Reviewing for ACS Publications

ACS Publications and the Award Committee are excited to announce the recipients of the ACS Publications Travel Grant for Librarians and Library School Students to attend the Spring 2020 ACS National Meeting & Exposition in Philadelphia:

Joshua Borycz, Librarian for Stem Research, Vanderbilt University

Twitter: @JoshuaBorycz

Joshua Borycz began his scientific career studying chemistry and mathematics at Hope College in Holland, MI. He performed geochemical research with Professor Graham Peaslee for two years and, in his last year of coursework, developed an interest in computational chemistry. He decided to apply for a Ph.D. program at the University of Minnesota to work with Laura Gagliardi using quantum mechanical methods on materials for carbon capture and catalysis. During his time at Minnesota, he became interested in the scientific process itself and why publishing novel articles often took precedence over publishing and organizing quality research data. To learn more, he decided to pursue another degree in Information Science and learn more about how data organization within the sciences could be improved. He worked with Carol Tenopir and Suzie Allard at the University of Tennessee, Knoxville, for two years on research related to the practices and attitudes of scientists toward data sharing. This research opportunity helped him to attain a job at Vanderbilt University as a Librarian for STEM Research in 2019. At Vanderbilt, he is teaching a Chemical Literature course, acting as a data consultant for research groups, and spreading the word about the many tools and resources provided through the library.

Clair Castle, Librarian, University of Cambridge

Twitter: @chemlibcam

Clair Castle is the Librarian at the Department of Chemistry, University of Cambridge. She graduated from Loughborough University with a Joint Honours degree in Information & Library Studies and German. Castle is also a chartered member of CILIP, the UK’s library, and information association. She has worked for the University of Cambridge for over 20 years in various libraries and has been managing the Department of Chemistry Library service since 2013. She supports all research and teaching activities that take place in the Department. She has developed a particular interest in research data management – which she teaches to all-new Chemistry graduate students – and in scholarly communication and open research. She is also a Data Champion at the University: these are local experts on research data management and sharing who can provide advice and training within their departments.

Sharon Maria S. Esposo-Betan, Head Librarian, University of the Philippines College of Engineering Libraries

Twitter: @awong

Sharon Ma. S. Esposo-Betan is the Head Librarian of the University of the Philippines (UP) College of Engineering Libraries. She is responsible for all aspects of resources management, collection development, and overall planning and development. Her involvement in various organizations in the field of librarianship ushered her to teaching in the UP School of Library and Information Studies as Senior Lecturer. She earned her Bachelor of Science in Social Work and Master of Library and Information Science degrees from the University of the Philippines Diliman. She served as President of the Consortium of Engineering Library-Philippines (CELPh) in 2017-2018 and President of the Philippine Association of Academic and Research Librarians (PAARL) in 2014. For her exemplary and worthy contribution to the development of academic librarianship in the country, she held various awards such as the 2018 Outstanding Academic/Research Librarian Award, 2016 Professional Service Award, and honorary membership to the International Honor Society of Phi Kappa Phi. Esposo-Betan is a 2-time awardee of the UP Gawad Tsanselor Award (2009 and 2015), the highest and the most prestigious university award given to a professional who has attained a high level of performance, demonstrated good leadership and exemplified honor and excellence within the service of the people.

Amanda McCormick, Chemistry & Physics Librarian, University at Buffalo

Twitter: @mccormick_afm

Amanda McCormick is a librarian with the Sciences and Engineering Library at the University at Buffalo. She serves as liaison to the departments of Chemistry and Physics, where she focuses on providing research support and instruction to students and faculty members. She holds a B.S. in Biology from Hobart and William Smith Colleges, a J.D. from the University at Buffalo School of Law, and an M.L.S. from the University at Buffalo Graduate School of Education. Her research interests focus on the communication of scientific information and the intersection of law, science, and information. Before entering science librarianship, McCormick worked as a public librarian and an attorney. Among other activities, she volunteers with the UB Women in STEM Cooperative and has assisted in the planning of an upcoming UB Libraries’ sponsored conference focusing on the use of emerging technologies in teaching.

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All four winners will be sharing their experiences from the National Meeting in future ACS Axial articles.

ACS Publications would like to thank the members of the Award Committee and everyone who applied for the travel grant. Librarians and students should keep their eyes open for a call for applications for the Fall 2020 ACS National Meeting & Exposition in San Francisco.

To celebrate an incredible 2019 for Organic Letters, Inorganic Chemistry, Organometallics, and The Journal of Organic Chemistry, ACS Publications has created posters featuring the vibrant cover art from the 24 issues published in each of these core-chemistry journals this past year. Cover artwork says a lot about chemists: Scientists do more than just research; they like to express their creativity and take pride in attractively presenting their results.

Download a high-resolution pdf of your favorite journal cover poster below. Use it as a screensaver, share it on social media, share it with colleagues and members of your research group, and impress your friends. Print your own or have a print shop do it for you to hang in your office, lab, or prominent location in your department.

You can also access high-resolution versions of each cover featured on the posters in the Cover Art Gallery on each journal’s website—check out 2020 and prior years:

Cover Art Criteria

At these four journals, the Editor-in-Chief’s office contacts authors to invite submissions of Front Cover artwork; however, the journals also consider volunteer suggestions. The journals are looking for visually captivating and scientifically interesting covers that exhibit simplicity, clarity, and eye-catching high-quality graphics. Some covers may include supporting text if the artwork is not self-explanatory. Please consult each journal’s author guidelines for specific criteria.

ACS journals also offer all authors to promote their work through Supplementary Covers, up to three of which are published each issue, with voluntary submissions subject to a selection process and processing fee.

Submit Your Next Paper

While you are at it, consider submitting your next paper to one of the core ACS Inorganic or Organic journals.

Organic Letters is the international forum for rapid communication of brief reports on cutting-edge research, creative approaches, and innovative ideas in all branches of the theory and practice of organic chemistry.
Inorganic Chemistry is the leading journal in its field, publishing fundamental studies, both experimental and theoretical, on new and known compounds focused on structure, bonding, spectroscopy, and reactivity of molecular and extended solid-state compounds and materials from across the Periodic Table, including the fields of catalysis, metalloprotein and bioinorganic chemistry, energy and photochemistry research, organometallic chemistry, and solid-state, materials, and nanoscale chemistry.
Organometallics is the global flagship publication of organometallic chemistry advancing science all across the Periodic Table, featuring research on synthesis, structure, bonding, chemical reactivity, and reaction mechanisms for a variety of applications, including catalyst design and catalytic processes, transition-metal and main-group inorganic chemistry, synthetic aspects of polymer and materials science, and bioorganometallic chemistry.
The Journal of Organic Chemistry is the premier forum for publishing inquisitive and thorough studies on all aspects of organic chemistry, from new reactions, structures, and functions through to their scope, mechanisms, and applications.

The Editorial Teams at these journals look forward to reviewing your research in 2020 and beyond. ACS salutes and thanks all editors, reviewers, and authors for the many roles you play in contributing to the global chemistry community.

The history of chemistry is full of important African American Chemists. But so is the present! “Diversity, inclusion, and respect” is one of the core values of the American Chemical Society, so in honor of African American History Month, ACS Publications is saluting the work of seven African American chemists whose work is pushing their respective disciplines forward. Click on the names below to learn more about their accomplishments and their research.
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Steven D. Townsend

Steven D. Townsend is an Assistant Professor of Organic Chemistry at Vanderbilt University. He serves on the editorial board of ACS Infectious Diseases.

What’s your proudest achievement so far in the field of chemistry?

My mentoring philosophy is to lead the group through positive reinforcement and enabling self-expression (or helping students become the best version of themselves). Accordingly, my proudest achievement so far is the trainees. We achieve excellent results through ingenuity, hard work, and scholarship while opposing the hyper-masculine culture of the past that sneers at compassion, teamwork, self-care, and those who leave work to maintain a personal life.

What’s a recent ACS paper that you’d like to highlight?

The recent ACS paper I’d like to highlight is a recent total synthesis that appeared about 6 months ago. The lab is known for human milk science, but this synthesis is our entry point into immunobiology and is the first of several synthetic efforts currently exiting the lab.

Total Synthesis of the Congested, Bisphosphorylated Morganella morganii Zwitterionic Trisaccharide Repeating Unit
J. Am. Chem. Soc. 2019, 141, 32, 12939-12945
DOI: 10.1021/jacs.9b06830

Paula T. Hammond

Paula T. Hammond is the David H. Koch Professor and Department Head of the Department of Chemical Engineering at MIT. She is the Associate Editor of ACS Nano.

What’s your proudest achievement so far in the field of chemistry?

I am in the field of Chemical Engineering, which is a fascinating and rewarding field that has enabled me to work on everything from polymer-based thin film batteries to biomedical devices and cancer-targeting nanoparticles. To be honest, my proudest achievements among all of these are really the many students and postdocs that I have mentored over that time and their many successes in life and career. I think that as an academic, it is my role to both bring forward the best science that can impact our world and produce the top engineers and scientists to further address the world’s problems.

What’s a recent ACS paper that you’d like to highlight?

I am very excited about the upcoming ACS Nano paper that was just released ASAP:(Tuning Nanoparticle Interactions with Ovarian Cancer through Layer-by-Layer Modification of Surface Chemistry, ACS Nano 2020, Publication Date: January 23, 2020, https://doi.org/10.1021/acsnano.9b09213) because it represents very careful work in which we found that using electrostatic layer-by-layer assembly of polyelectrolytes on the surface of a nanoparticle, we could design nanoscale coatings on these particles that strongly target ovarian cancer cells over healthy cells. We found that by adapting the type of polymer used as the final outer layer, we can influence where the nanoparticle goes and how it engages with cancer cells, thus allowing us to use these design principles to better direct drugs to different regions inside or outside of cells.
Tuning Nanoparticle Interactions with Ovarian Cancer through Layer-by-Layer Modification of Surface Chemistry
ACS Nano 2020, 14, 2, 2224-2237
DOI: 10.1021/acsnano.9b09213

Malika Jeffries-EL

Malika Jeffries-El is an Associate Professor in the Department of Chemistry at Boston University. She was an ACS Fellow in 2018, and recipient of the Stanley C. Israel Regional Award for Advancing Diversity in the Chemical Sciences.

What’s your proudest achievement so far in the field of chemistry?

Scientifically, I am proud of my ability to design useful materials and develop the synthetic routes needed to make them. I have also had to evolve from being an organic chemist to a materials chemist to fully develop our materials. Personally, I am most proud of the people I have been able to mentor and train in my lab. I have had the opportunity to work with an amazingly diverse group of people who have gone on to great scientific careers in chemistry.

What’s a recent ACS paper that you’d like to highlight?

In this work, we evaluate the impact of fluorination on the optical and electronic properties of a series of organic semiconductors. Such systems are of interest for the development of blue-light emitting OLEDs. I am particularly happy with the work because it was part of a special issue in honor of National Organization of Black Chemist and Chemical Engineers (NOBCChE) founder William Jackson.

Evaluating the Impact of Fluorination on the Electro-optical Properties of Cross-Conjugated Benzobisoxazoles
J. Phys. Chem. A 2019, 123, 7, 1343-1352
DOI: 10.1021/acs.jpca.8b07778

Jason K. Sello

Jason K. Sello is the Professor of Pharmaceutical Chemistry at the University of California, San Francisco.

What’s your proudest achievement so far in the field of chemistry?

My career as a scientist has yielded much about which I am very proud. My pride comes not just from discoveries that have changed how we think about biological chemistry and opened new avenues for drug development, but also from the successful careers of those who have worked with me in the discovery process. This is perhaps best exemplified by an on-going project directed towards the development of a first-in-class antibacterial drug. It is inspired by molecules called cyclic acyldepsipeptides (ADEPs) that are produced by two different species of soil bacteria for chemical defense against competing bacteria in their ecological niche. We were attracted to the ADEPs because they target the ClpP protease, which is not the target of any currently marketed drug. Though the ADEP natural products had good antibacterial activity in the laboratory, they had poor pharmacological properties and thus no efficacy in animal models of infection. To overcome the liabilities, we used chemical synthesis guided by principles of rational drug design to produce novel ADEPs that were markedly more potent and can cure bacterial infections in mice. Through a longstanding collaboration with Prof. Robert Sauer at the Massachusetts Institute of Technology (MIT), we have gained fundamental insights into how the ADEPs bind bacterial ClpP and elucidated how that binding effectuates killing of bacteria via one of two different mechanisms (depending on the bacterial species). We are now working to define the potential of our novel and patented ADEPs as drug leads for the treatment of tuberculosis, through collaborative efforts with Dr. William Bishai at the Johns Hopkins University. Our studies of the ADEPs has been a highlight of my career because of the breadth of their impact- they have taught us about the correlation between molecular dynamics and bioactivity, revealed new insights into the enzymology of protein degradation, and illuminated a pathway for the development of new anti-bacterial drugs.

Aside from the scientific progress, I take great pride in the successes of my co-workers who have worked with me on the ADEPs. Two post-doctoral fellows engaged in studies of these molecules have gone on to faculty positions at the University of Delaware and Queens University of Charlotte and another is now a research scientist at the National Institutes of Health. Three graduate students who made key contributions are now working as research scientists at Takeda, MilliporeSigma, and the Broad Institute of Harvard and MIT and a fourth graduate student is now a business development executive at Bristol-Myers Squibb. Five undergraduate co-workers have gone on to graduate studies at University of Cambridge, Harvard University, Yale University, and MIT; two of them have earned degrees and are now working at FormLabs and Takeda. I am grateful to have had the opportunity to work with such talented young scientists and look forward to all that they will achieve in the future.

What’s a recent ACS paper that you’d like to highlight?

This is a great opportunity to mention a very exciting paper that has been recently accepted for publication in ACS Chemical Biology. It describes our surprising findings that the ADEPs and a fragment having ~30% the mass of the parent molecules are nearly equally good at killing Mycobacterium tuberculosis, yet they engage and perturb ClpP in completely different ways. Whereas the ADEPs block the essential interaction of the peptidase and its chaperone, our experiments indicate that the ADEP fragment stabilizes the interaction of ClpP with its chaperone ClpX and in turn enhances the complex’s proteolytic activity. Our findings have prompted us to contemplate an unconventional strategy in drug development wherein small molecules are used to stabilize protein-protein interactions. It’s our hope that this paper will inspire others to approach the therapeutic targeting of oligomeric protein complexes in different ways, too.

Acyldepsipeptide Antibiotics and a Bioactive Fragment Thereof Differentially Perturb Mycobacterium tuberculosis ClpXP1P2 Activity in vitro
ACS Chem. Biol. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acschembio.9b00454

Elissia T. Franklin

Elissia T. Franklin is a Post-Doctoral Research Associate at Purdue University.

What’s your proudest achievement so far in the field of chemistry?

Representation in chemistry is essential to help those who do not typically see people who look like themselves feel that they belong. My proudest moments so far in the field have been hearing from early-career scientists that I have been an inspiration to them in some way. Purdue University’s chemistry program is one of the most racially diverse and it allowed me to offer support and be supported by chemists with whom I share similar experiences. I’ve published articles, presented my research, and received various accolades. None of this compares to the most satisfying experiences which have been centered around outreach. My podcast has allowed me to connect with many different people, shed a positive light on black women in STEM, it has granted me the opportunity to share with the world the importance of diversity and inclusion.

What’s a recent ACS paper that you’d like to highlight?

I chose to highlight this paper due to the real-life application and the broader implication that this research demonstrates for lipid analysis.

Predicting Breast Cancer by Paper Spray Ion Mobility Spectrometry Mass Spectrometry and Machine Learning
Anal. Chem. 2020, 92, 2, 1653-1657
DOI: 10.1021/acs.analchem.9b03966

Thomas H. Epps

Thomas H. Epps, III is the Director of the Center For Research in Soft Matter & Polymers (CRISP) at the University of Delaware. He is a member of ACS Applied Polymer Materials’ Editorial Advisory Board and serves on the ACS Board of Directors Development Advisory Board.

What’s your proudest achievement so far in the field of chemistry?

One career highlight has been my group’s sustainable polymers research thrust that started as a collaborative effort with the late Prof. Richard Wool in 2013. In just a few years – and with the hard work and creativity of numerous postdocs, graduate students, and undergraduate students – we have developed a robust biobased polymers platform focused on valorizing lignin. This effort is a particular highlight for me because it has led to several fun and fruitful collaborations with colleagues at the University of Delaware, at several other institutions, and with numerous companies. More recently, some of our lignin-based polymer work has been featured on the cover of ACS Central Science in 2018, been a centerpiece of a $3.7 million NSF Growing Convergence Research grant, and led to the founding of a startup company (Lignolix) that has received several innovation-related awards from the University, State, and Region.

What’s a recent ACS paper that you’d like to highlight?

Another career highlight is leading the NSF-sponsored Future Faculty Workshop (FFW) program with a goal to provide additional opportunities for students and postdoctoral researchers from underrepresented groups on the path to the professoriate. I was honored to be asked to takeover leadership of this established program, focused on soft materials, and I have truly enjoyed the opportunity to keep the FFW moving onward and upward as an impactful model for mentorship and engagement. Moreover, it has been a distinct privilege to work with many soft matter-focused colleagues from across the country, who have been willing to spend time to mentor, train, and share experiences with the next generation of faculty. On a more personal level, a particular highlight of this activity has been reading the reviews from the students/postdocs impacted by the workshop and learning about how our program has positively influenced individual paths to academia.

From Tree to Tape: Direct Synthesis of Pressure Sensitive Adhesives from Depolymerized Raw Lignocellulosic Biomass
ACS Cent. Sci. 2018, 4, 6, 701-708
DOI: 10.1021/acscentsci.8b00140

Oluwatobi (Tobi) Odeleye

Oluwatobi (Tobi) Odeleye is a Professor in the Department of Chemistry and Biochemistry at the University of Oklahoma and the author the forthcoming ACS eBook “Chemistry Student Success”

What’s your proudest achievement so far in the field of chemistry?

One of the highlights of my career so far was being able to co-host a symposium with my mentor (“A day in the life of my classroom”) at the 2018 Biennial Conference on Chemical Education (BCCE), which drew several instructors with different teaching experience levels and diverse backgrounds. This was a highlight for me because it created an avenue for dialogue and for instructors to be real about their successes, but also their struggles, and as a new instructor, this was very helpful and encouraging to me. This was also a highlight because, with the help of the presenters at the symposium, we were able to develop the symposium into a forthcoming ACS eBook, Chemistry Student Success!