April 2020 - ACS Axial | ACS Publications

Accounts of Chemical Research Recognizes First Accounts

Accounts of Chemical Research is known for publishing highly read and cited accounts that tell the story of a research project from conception to conclusion. They are like “seminars-in-print,” which analyze the state of the art, provide the motivation behind and significance of the goals, and lay out the framework of the experimental design. They also summarize the results from earlier key papers from the authors’ own labs and critically assess how the research has moved the field forward in relation to other work in the field. More often than not, they are written by established researchers with long histories of publishing high-quality research.

Fresh and New

Recognizing that early-career scientists have some of the freshest ideas and are instrumental in pushing the frontiers of chemistry and related disciplines, the Editors of Accounts of Chemical Research created the inaugural First Accounts Virtual Issue, highlighting articles authored by early-career scientists over the past year. To identify the qualifying group, the editors looked at all corresponding authors who published their first-ever accounts in 2019 and then narrowed the list down to those who had earned their Ph.D. in 2008 or beyond, which resulted in the journal’s final list of 29 First Accounts.

This virtual issue illustrates how early career researchers are some of the most engaged in experimental design and execution in the laboratory. And their passion for molecular design, mechanistic inquiry, and structural evidence comes through in each of the accounts included in the virtual issue.

Read the virtual issue.

PS: If you are an early-career researcher interested in submitting an account, Accounts of Chemical Research invites you to share your research story. For more information, be sure to read the journal’s guidelines on how to submit a proposal before writing.



Call for Papers: Special Issue on Proteomics and its Application in Pandemic Diseases

The Journal of Proteome Research is preparing to publish a special issue on Proteomics and its Applications in Pandemic Diseases, and its editorial team invites you to submit a manuscript for consideration.

Submission Deadline: June 30, 2020

Proteomics & Pandemics

The modern ease of travel and trade has increased the world’s vulnerability to rapidly transmitted pandemic diseases, which can lead to global hardship, including economic and human loss. We are witnessing this in the ongoing novel coronavirus (COVID-19) pandemic, which continues to spread in the absence of a vaccine to prevent infection and drugs to treat it

It is important to understand both COVID-19 and pandemic diseases in general, so we can find vaccines and cures to save precious human lives. Proteomics may play an important role in developing this understanding and has great potential in investigating pathogenesis, molecular mechanism, identifying targets, biomarkers, developing novel therapeutics, and drug repurposing in pandemic diseases.

Call for Papers

Dr. Suman S. Thakur, Senior Scientist in Proteomics and Cell Signaling at the Centre for Cellular and Molecular Biology (CCMB) in Hyderabad, India, is the Guest Editor for this special issue. He invites you to submit original research and review articles covering these topics connecting proteomics and pandemic diseases:

  • Early detection using biomarkers
  • Pathogenesis and proteome dynamics
  • Molecular and mechanistic details of proteins
  • Protein-protein interactions in macromolecular complexes
  • Signaling pathways
  • Quantitative proteomics: Label-free/label quantitation from bio-fluids and tissues
  • Post-translational modifications
  • Computational proteomics
  • Prevention and vaccination
  • Drug response and repurposing of drugs
  • Novel targets, therapeutic agents, and their mode of action

Manuscript Requirements & Submission Deadline

Manuscripts must be submitted electronically through the ACS Paragon Plus Environment online submission system by June 30, 2020, and conform to the Journal of Proteome Research Author Guidelines. In your cover letter, please specify that the manuscript is intended for the special issue on Proteomics and its Application in Pandemic Diseases.

Get Full Text Research Pilot is Now Live

In December 2019, Get Full Text Research (GetFTR) was announced as a new, free-to-use solution that enables faster access for researchers to the published journal articles they need. Seamless, off-campus access to scholarly content is now more important than ever, and the scholarly platforms DimensionsFigshareSymplecticReadCube Papers, and Mendeley have started a pilot of the GetFTR service. Even more discovery services are working on integrating GetFTR. Those updates will be announced in the coming weeks.

As part of the pilot, some researchers using Dimensions, Figshare, Symplectic, and Mendeley will begin to see a ‘GetFTR article’ link next to subscription-based articles, which will take them directly to the full-text article if they have access through their institutional affiliation. Entitlements from five publishers, including the American Chemical Society, are included in this initial pilot.

Read more information about the GetFTR pilot here.

Professor Jason S. Lewis to Receive the 2020 Bioconjugate Chemistry Lectureship Award

Bioconjugate Chemistry and the ACS Division of Polymeric Materials Science and Engineering (PMSE) are pleased to announce the recipient of this year’s 2020 Bioconjugate Chemistry Lectureship Award.  Please join them in congratulating Professor Jason S. Lewis, Ph.D., of the Memorial Sloan Kettering Cancer Center (MSK) in New York City.

Jason S. Lewis is currently the Emily Tow Jackson Chair in Oncology at Memorial Sloan Kettering Cancer Center (MSK) in New York. He is the Chief Attending of the Radiochemistry & Imaging Sciences Service and serves as the Vice Chair of Research in the Department of Radiology at MSK. He holds a joint appointment in the Molecular Pharmacology Program, and he is the Director of the Radiochemistry & Molecular Imaging Probe Core in the Sloan-Kettering Institute. He also holds appointments as a Professor at the Gerstner Sloan-Kettering Graduate School of Biomedical Sciences in New York City, and the Weill Cornell Medical College at Cornell University in Ithaca, New York. He is an Adjunct Professor in the Department of Biomedical Imaging and Image Guided Therapy, The Medical University of Vienna in Vienna, Austria.

Lewis earned a B.Sc. in Chemistry in 1992 and a M.Sc. in Chemistry in 1993 from the University of Essex and then in 1996 obtained a Ph.D. in Biochemistry from the University of Kent with Professor Philip J. Blower. His postdoctoral work was with Professors Carolyn J. Anderson and Michael J. Welch at the Washington University School of Medicine (WUSM).  Subsequently, he joined the WUSM faculty as an Assistant Professor of Radiology at the Mallinckrodt Institute of Radiology (2003-2008). Professor Lewis then joined MSK in 2008.

Professor Lewis’ research program is a molecular imaging-based program focused on radiopharmaceutical development, as well as the study of multimodality (positron emission tomography, computerized tomography scans, and magnetic resonance imaging) small- and biomolecule-based agents and their clinical translation. He has worked on the development of small molecules targeting aberrant metabolism, as well as radiolabeled peptides and antibodies probing the overexpression of receptors and antigens on tumors. His research interests are focused on the development of new molecular imaging agents for the diagnosis and treatment of cancer. He has published more than 300 papers and reviews in the field of radiochemistry and molecular imaging.

The Bioconjugate Chemistry Lectureship Award is presented annually to recognize outstanding researchers for important recent advances in interfacing synthetic and biological systems. Jason S. Lewis joins a prestigious class of past recipients, including Heather D. Maynard, Wolfgang J. Parak, Matthew B. Francis, and Xiaoyuan Chen. “Jason Lewis is a highly innovative, driving force in the rapidly evolving and critical field of radiopharmaceuticals,” says Vincent Rotello, Ph.D., Editor-in-Chief of Bioconjugate Chemistry.

Read a Selection of Papers from Professor Lewis:

A Systematic Evaluation of Antibody Modification and 89Zr-Radiolabeling for Optimized Immuno-PET
Bioconjugate Chem. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acs.bioconjchem.0c00087
Multimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel Wall
Bioconjugate Chem. 2020, 31, 2, 360-368
DOI: 10.1021/acs.bioconjchem.9b00256
Bioorthogonal Masking of Circulating Antibody–TCO Groups Using Tetrazine-Functionalized Dextran Polymers
Bioconjugate Chem. 2018, 29, 2, 538-545
DOI: 10.1021/acs.bioconjchem.8b00028
Click Chemistry and Radiochemistry: The First 10 Years
Bioconjugate Chem. 2016, 27, 12, 2791-2807
DOI: 10.1021/acs.bioconjchem.6b00561
PET Imaging of Extracellular pH in Tumors with 64Cu- and 18F-Labeled pHLIP Peptides: A Structure–Activity Optimization Study
Bioconjugate Chem. 2016, 27, 9, 2014-2023
DOI: 10.1021/acs.bioconjchem.6b00306

ACS Editors’ Choice: Minimalistic Principles for Designing Small Molecules with Multiple Reactivities against Pathological Factors in Dementia

This week: Minimalistic principles for designing small molecules with multiple reactivities against pathological factors in dementia — and more!

Each and every day, ACS grants free access to a new peer-reviewed research article from one of the Society’s journals. These articles are specially chosen by a team of scientific editors of ACS journals from around the world to highlight the transformative power of chemistry. Access to these articles will remain open to all as a public service.

Check out this week’s picks!
Postulated Biogenesis-Guided Total Synthesis and Structural Revision of 2,18-seco-Lankacidinol A
Org. Lett. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acs.orglett.0c00993
Minimalistic Principles for Designing Small Molecules with Multiple Reactivities against Pathological Factors in Dementia
J. Am. Chem. Soc. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/jacs.9b13100
Potentiostatically Controlled Olefin Metathesis
Organometallics 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acs.organomet.0c00052
Biocatalysts from Biosynthetic Pathways: Enabling Stereoselective, Enzymatic Cycloether Formation on a Gram Scale
ACS Catal. 2020, 10, XXX, 4973-4982
DOI: 10.1021/acscatal.9b05071
Chemical Sensitivity Analysis and Uncertainty Analysis of Ozone Production in the Comprehensive Air Quality Model with Extensions Applied to Eastern Texas
Environ. Sci. Technol. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acs.est.9b07543
Close Amide NH···F Hydrogen Bonding Interactions in 1,8-Disubstituted Naphthalenes
J. Org. Chem. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acs.joc.0c00553
NIR-II Dual-Modal Optical Coherence Tomography and Photoacoustic Imaging-Guided Dose-Control Cancer Chemotherapy
ACS Appl. Polym. Mater. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acsapm.0c00155
Love ACS Editors’ Choice? Get a weekly e-mail of the latest ACS Editor’s Choice articles and never miss a breakthrough!


Celebrate ACS Sensors’ 5th Anniversary

This year marks ACS Sensors’ 5th Anniversary. In celebration of this milestone, the journal is producing a Virtual Issue collection. Issues will be released periodically throughout the year.

ACS Sensors’ 5th Anniversary Virtual Issue Collection Series

This series of Virtual Issues will focus on the People of ACS Sensors, which the journal’s Editor-in-Chief, Professor Justin Gooding, suggests are pivotal to the journal’s success. Here are the planned Virtual Issues:

  • Giants in Sensing
  • Emerging Investigators in Sensing
  • Sensors & Industry
  • Editorial Advisory Board 

Read the Editorial for more information about the 5th Anniversary Collection. 

Looking Back on the Last Five Years

When the journal launched in 2015, the goal of the editorial team was to provide a top forum to publish all aspects of sensing from the conceptual to the applied, for chemists, engineers, physicists, and biologists. The ACS Sensors’ team achieved that far sooner than they anticipated.

“Five years ago, ACS Sensors did not exist. Now it is the fourth-ranked analytical chemistry journal and the second-ranked journal that publishes primary research based on the impact factor of 6.944,” Professor Gooding said. Submissions this year are also expected to exceed 3,000.

The team’s other main goal was to convince the sensor science community that ACS Sensors was their journal; that it was published for them so that they have a venue they trust and respect for their best work. Personalized outreach, in-person events, and receptions have been key to building that sense of community.

In the next five years, Professor Gooding plans to “continue to strengthen the journal and its brand as the prestige venue to publish sensing  papers.” The ACS Sensors Team does not plan on adjusting the scope, which they believe played a large part in the success of the journal in building its community. Professor Gooding does, however, plan to further diversify the journal, from increasing gender representation on the board to increasing topic diversity within the ACS Sensor’s editors, especially in terms of gas sensing, plasmonic sensing, and devices.

Be sure to sign up for journal alerts to receive notifications when a new Virtual Issue within the 5th Year Anniversary collection is released.

Read the Editorial for more information about the 5th Anniversary Collection. 

Don’t Miss Out: Share Your #ACSPhilly Posters During #ACSSciMeet, via SciMeetings

In response to the termination of the ACS Spring 2020 National Meeting & Expo, ACS launched SciMeetings – a platform for showcasing scientific presentations and posters, created in partnership with the proven technology of Morressier. Authors of presentations and posters scheduled for the ACS Spring 2020 National Meeting have been uploading their conference material since March 19. They can continue to do so at no cost through April 30.

More than 1,000 posters and presentations have now been uploaded to SciMeetings, and so #ACSSciMeet will allow users to share their research in an online week-long social media event held on Twitter and Instagram. The aim: to enable presenters to share their posters and presentations (via the provided Morressier DOI link), network, and engage in meaningful discussions with the scientific research community.

Join the 2020 #ACSSciMeet social media event!

1) Submit your poster to SciMeetings before COB April 27, 2020.

2) Make sure your social media accounts are set to public view and are ready to share your work.

3) During the social media event beginning, 9:00 A.M. EDT April 28, 2020, you should:

  • Share your Morressier or DOI link to your SciMeetings research on Twitter.
  • Include details about your work, tag @AmerChemSociety, your co-authors and remember to use the hashtag #ACSSciMeet

Pitch your poster on Instagram:

  • Record a 1-minute poster pitch using a customized Zoom background, featuring your poster, and share it on Instagram. (Zoom backgrounds will be distributed to presenters via email)
  • Tag @AmerChemSociety and #ACSSciMeet, and we’ll share to our story

4) Discuss and engage.

  • Make sure to answer questions from the community and comment on other #ACSSciMeet posters throughout the day

Participants in #ACSSciMeet will be eligible to win a $100 VISA gift certificate sponsored by SciMeetings and ACS on Campus. The 25 winners will be selected at random and will be notified via email.

I&EC Research Highlights: Chemistry for New Frontiers

Industrial & Engineering Chemistry Research is pleased to publish a collection of invited articles from authors who made outstanding presentations at the ACS Spring 2019 National Meeting in Orlando. This compilation is the journal’s seventh showcasing of such invited articles from an ACS National Meeting. We are delighted to highlight these authors and their work published in I&EC Research. All of the articles in this collection touch on materials science or engineering.

The applications covered in this collection include:

Recovery of Critical Rare Earth Elements using ETS-10 Titanosilicate

Ind. Eng. Chem. Res. 2019, 58, 25, 11121-11126
DOI: 10.1021/acs.iecr.9b02623
Fabrication of CsPbBr3 Perovskite Quantum Dots/Cellulose- Based Colorimetric Sensor: Dual-Responsive On-Site Detection of Chloride and Iodide Ions

Ind. Eng. Chem. Res., 2020, 59, 2, 793-801
DOI: 10.1021/acs.iecr.9b05946
Antibacterial Polyurethane Foams with Incorporated Lignin-Capped Silver Nanoparticles for Chronic Wound Treatment

Ind. Eng. Chem. Res., 2020, 59, 10, 4504-4514
DOI: 10.1021/acs.iecr.9b06362
In Situ Modification of Regenerated Cellulose Beads: Creating All-Cellulose Composites

Ind. Eng. Chem. Res. 2020, 59, 7, 2968-2976
DOI: 10.1021/acs.iecr.9b06273
Impact of Drying on Meso- and Nanoscale Structures of Citrus Fiber: A Study by SFG, ATR-IR, XRD, and DLS

Ind. Eng. Chem. Res. 2020, 59, 7, 2718-2724
DOI: 10.1021/acs.iecr.9b06194
Beyond Idealized Models of Nanoscale Metal Hydrides for Hydrogen storage

Ind. Eng. Chem. Res. 2020, 59, 13, 5786-5796
DOI: 10.1021/acs.iecr.9b06617

Phillip E. Savage is the Editor-in-Chief of Industrial & Engineering Chemistry Research.

Celebrate Earth Week 2020 with Resources from the Journal of Chemical Education

Chemists Celebrate Earth Week 2020 will occur April 19-25, 2020, and this year’s theme is “Protecting Our Planet through Chemistry.” The articles, activities, and experiments listed below provide ideas and suggestions for engaging students on the topic of sustainability in order to connect real-world issues to the teaching environment. Success in integrating sustainability considerations into the practice of chemistry highlights the substantial impact that chemistry education can have to better equip students to address the sustainability of the Earth and societal systems.

With 97 volumes of interesting material on a wide variety of topics, it is easy to connect the classroom experience to the greater world through the Journal of Chemical Education.

Special Issue: Resources on Sustainability

Special Issue: Reimagining Chemistry Education: Systems Thinking, and Green and Sustainable Chemistry

The entire December 2019 issue of the Journal of Chemical Education is a rich resource of articles with a focus on sustainability.

Incorporating Sustainability into the Curriculum

Development and Implementation of a Series of Laboratory Field Trips for Advanced High School Students To Connect Chemistry to Sustainability
Journal of Chemical Education 2015, 92 (4), 631-637
DOI: 10.1021/ed500630f
Paper to Plastics: An Interdisciplinary Summer Outreach Project in Sustainability
Journal of Chemical Education 2014, 91 (10), 1574-1579
DOI: 10.1021/ed400892t
Campus as a Living Laboratory for Sustainability: The Chemistry Connection
Journal of Chemical Education 2017, 94 (8), 1036-1042
DOI: 10.1021/acs.jchemed.6b00624
Beyond “Inert” Ideas to Teaching General Chemistry from Rich Contexts: Visualizing the Chemistry of Climate Change (VC3)
Journal of Chemical Education 2017, 94 (8), 1027-1035
DOI: 10.1021/acs.jchemed.6b01009
Green Chemistry and Sustainability: An Undergraduate Course for Science and Nonscience Majors
Journal of Chemical Education 2013, 90 (4), 429-431
DOI: 10.1021/ed200756z
Teaching Green and Sustainable Chemistry: A Revised One-Semester Course Based on Inspirations and Challenges
Journal of Chemical Education 2014, 91 (7), 1084-1086
DOI: 10.1021/ed400393b
Incorporating Sustainability and Life Cycle Assessment into First-Year Inorganic Chemistry Major Laboratories
Journal of Chemical Education 2016, 93 (4), 639-644
DOI: 10.1021/acs.jchemed.5b00281
Simple and Effective Integration of Green Chemistry and Sustainability Education into an Existing Organic Chemistry Course
Journal of Chemical Education 2018, 95 (8), 1301-1306
DOI: 10.1021/acs.jchemed.7b00720
Chemistry of Sustainable Products: Filling the Business Void in Green-Chemistry Curricula
Journal of Chemical Education 2019, 96 (4), 647-651
DOI: 10.1021/acs.jchemed.8b00619

Exploring Sustainability with Activities

Colorful and Creative Chemistry: Making Simple Sustainable Paints with Natural Pigments and Binders
Journal of Chemical Education 2017, 94 (2), 211-215
DOI: 10.1021/acs.jchemed.6b00591
Releasing Stored Solar Energy within Pond Scum: Biodiesel from Algal Lipids
Journal of Chemical Education 2012, 89 (2), 239-242
DOI: 10.1021/ed200098c
Green Soap: An Extraction and Saponification of Avocado Oil
Journal of Chemical Education 2015, 92 (10), 1763-1765
DOI: 10.1021/acs.jchemed.5b00188
From Lobster Shells to Plastic Objects: A Bioplastics ActivityJournal of Chemical Education 2015, 92 (11), 1882-1885
DOI: 10.1021/acs.jchemed.5b00108
A Simple Photocell To Demonstrate Solar Energy Using Benign Household Ingredients
Journal of Chemical Education 2013, 90 (10), 1358-1361
DOI: 10.1021/ed3001232

Investigating Sustainability in the Laboratory

Dyeing to Degrade: A Bioplastics Experiment for College and High School Classrooms
Journal of Chemical Education 2019, 96 (11), 2565-2573
DOI: 10.1021/acs.jchemed.9b00461
Making Sustainable Biofuels and Sunscreen from Corncobs To Introduce Students to Integrated Biorefinery Concepts and Techniques
Journal of Chemical Education 2018, 95 (8), 1376-1380
DOI: 10.1021/acs.jchemed.7b00819
Evaluating Sustainability: Soap versus Biodiesel Production from Plant Oils
Journal of Chemical Education 2012, 89 (8), 1053-1056
DOI: 10.1021/ed100451d
Extraction and Antibacterial Properties of Thyme Leaf Extracts: Authentic Practice of Green Chemistry
Journal of Chemical Education 2016, 93 (8), 1422-1427
DOI: 10.1021/acs.jchemed.5b00891
From Scrap to Functional Materials: Exploring Green and Sustainable Chemistry Approach in the Undergraduate Laboratory
Journal of Chemical Education 2019, 96 (3), 535-539
DOI: 10.1021/acs.jchemed.8b00484
Discovering Inexpensive, Effective Catalysts for Solar Energy Conversion: An Authentic Research Laboratory Experience
Journal of Chemical Education 2016, 93 (4), 650-657
DOI: 10.1021/acs.jchemed.5b00591
Introducing Environmental and Sustainable Chemistry Topics Using a Nanotechnology Approach: Removing Hazardous Metal Ions by Means of Humic-Acid-Modified Superparamagnetic Nanoparticles
Journal of Chemical Education 2016, 93 (11), 1929-1934
DOI: 10.1021/acs.jchemed.6b00172

ACS Central Science Author Interview – Safety First: A Recent Case of a Dichloromethane Injection Injury

Lab safety is everyone’s responsibility. One common piece of equipment that doesn’t always receive as much safety-related attention is the use of needles in chemistry labs.

I recently interviewed Sébastien Vidal and Nicolas Scaglione of the University Lyon 1, who are (respectively) the author/supervisor and the main protagonist of an ACS Central Science editorial, which has generated much discussion in the chemistry community: “Safety First: A Recent Case of a Dichloromethane Injection Injury.”

Read the Open Access Editorial

In this incredible account, Sébastien Vidal outlines the accident that took place and the procedures they followed to obtain medical attention for Nicolas Scaglione.

In our interview, I delved into some more questions with both scientists.

Read the Interview

How did that day start for you, Nicolas?

It started as a normal day. I arrived at the lab, went to my desk to get what I need to start my reaction, and to say hello to everybody in the office. Then, I directly went to the lab to start my reaction, so, it was a typical start.

What happened next?

I was preparing my flask because it was a reaction carried under argon. Then, I wanted to inject my solvent inside the flask, but I forgot to put a needle as an exit. So, when I injected the solvent, because of an overpressure, the stopper popped out of the flask, then, the needle suddenly moved, and it poked my finger which was next to the flask.

Sébastien, you were in your office that morning, what was your first thought when your students came to tell you what had happened?

At first, I felt like this was another simple situation when students get poked with a needle. I was about to go and get the medikit to help him, but when I saw the purple coloration on his finger, I immediately felt that something was wrong.

Then Nicolas told me that he was injecting dichloromethane to set up his reaction that we had discussed the day before. Knowing how toxic this solvent is when in contact with skin (an extreme and immediate burning sensation when the solvent reaches under a rubber glove or wristwatch or ring), this is when I started to realize that this situation would be more complicated than it first seemed.

You knew you needed to act quickly. Fortunately, you have a hospital near campus that you could attend. What was the doctor’s reaction when you arrived?

Nicolas was first examined by a doctor and then the surgeon. We asked at the desk to immediately see a doctor for a quick assessment of the damage. The doctor came after 10-15 minutes, and he confirmed the unusual wound and diagnosed necrosis and nerve damage.

So Nicolas was then set up for a fast track surgery within the next hour but, there was a necessary further delay because another emergency came in just at that time with a worker and all his fingers cut off! After that surgery, the surgeon then started operating on Nicolas’ finger.

We only learned from him a few days after surgery, while Nicolas was going for post-operation follow up, that his first assessment was to cut off the finger due to the extent of the necrosis. But he wanted to try saving the finger for a young man in his early twenties.

Nicolas, you had to have an emergency operation on your finger. Do you remember how you felt when you heard that news?

I was very worried. I didn’t know exactly what was happening to my finger because they told me that it was necrosis. I didn’t really know what the surgeon wanted to do to cure my finger. So, the most stressful part was to not know what was going to happen. However, I was reassured to be with the surgeon that fast, I was afraid to have to wait a long time in this situation.

Sébastien, while Nicolas was in surgery, you reviewed the SDS – Safety Data Sheet – for information about dichloromethane injuries. What did you find?

I could use my smartphone to search on the internet for all possible aspects of this accident. At that time, I did not talk to the surgeon, and I was not even sure of the extent of the wound or even whether the nerve would be affected or not.

So, I searched for information about reported dichloromethane injections or accidents. I could find information about many possible exposures, but nothing about an injection. I even found information about a man who fell into a tank of dichloromethane and did not survive.

Yet, nothing about an injection of this solvent under the skin. I also looked at SDS for similar solvents like chloroform or 1,2-dichloroethane. But, still, without success. This is when I started understanding that such a situation of “injection” was never included in the SDS.

Nicolas, how is your thumb now, almost two years after the incident?

Now, my finger still looks like the picture “1 year after the accident”. My sense of touch is still missing, but I have learned how to live without it. The mobility is fine thanks to the physiotherapy, and I learned how to use my finger as I was used to. To sum up, I can use my finger as it was before the incident, even if sometimes I have some strange feelings.

Sébastien, your goal of sharing this accident was to raise awareness of the dangers of accidental injection and to try to prevent other accidents. Do you feel that you’ve achieved what you set out to do?

Our goal in sharing this accident was to alert chemists about the hazard involved with such a simple procedure that is performed endlessly in organic chemistry laboratories. Even though Nicolas could have performed his injection better, this situation can happen to anyone at any time without knowing the consequences.

It will be very difficult to avoid poking yourself with a needle throughout your career. But just be aware that dramatic consequences might arise under specific circumstances.

Another major concern is the lack of information about the injection of solvent in the SDS. The industry and authorities should consider setting up a campaign for the evaluation of this risk with common organic solvents and then provide to our community a safer set of data for risk management.

Do You Have More Questions?

Since the Editorial was published, Sébastien and Nicolas have received many important follow-up questions via email and on Twitter. In an effort to help continue this dialogue, I’ve listed some of the questions below, with answers from Sébastien and Nicolas.

Members of the community are encouraged to post additional questions via the comments section below so that Sébastien and Nicolas can respond to them as well.

Usually, when you hurt yourself with a needle, you have a tendency (and it is correct to do so) to press on the wound and have blood externalized so that some of the contaminants would be removed. Did you observe any bleeding with this injury?

Sébastien: In the specific case of Nicolas, the wound did not bleed after a few minutes. My first interpretation would be that the immediate necrosis that occurred clotted the blood into a solid material that prevented bleeding. This particularly increased the negative effect of this injection since dichloromethane could then diffuse deeper into tissues.

Nicolas: I don’t remember exactly, but just a few drops as far as I remember, at the very moment of injection, and it stopped very quickly.

How, exactly, did Nicolas stab his finger?

Nicolas: I was preparing my flask because it was a reaction carried out under argon. Then, I wanted to inject my solvent inside the flask, but I forgot to put a needle as an exit. So, when I injected the solvent, because of an overpressure, the stopper popped out of the flask, then, the needle suddenly moved, and it poked my finger which was next to the flask.

What – if any – alternatives to needles should individuals consider using in the lab, to avoid these types of accidents?

Sébastien: We cannot escape from sharp needles in organic chemistry since we need to inject liquids through a rubber stopper that is keeping our reaction vessel air/moisture-free.

But in many other cases, one uses sharp needles when not necessary, and flat-ended needles would be much less hazardous in this respect, or even plastic cones and pipettes would be even more adapted.

Can the article and related material be used in safety lectures?

Yes! The article is available open access under an ACS AuthorChoice license. Terms of use can be reviewed here.

Do you have more questions for Sébastien and Nicolas? Post them below, and they’ll respond!

Lab Safety Webinar

For more on lab safety, view this exclusive free webinar hosted by ACS Chemical Health & Safety Editor-in-Chief Mary Beth Mulcahy, along with the journal’s Managing Editor Kali Miller and ACS Committee on Chemical Safety Chair Ralph Stuart.