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ACS Editors’ Choice: Soft Printable Electrode Coating for Neural Interfaces

This week: Soft Printable Electrode Coating for Neural Interfaces — and more!

Each and every day, ACS grants free access to a new peer-reviewed research article from one of the Society’s journals. These articles are specially chosen by a team of scientific editors of ACS journals from around the world to highlight the transformative power of chemistry. Access to these articles will remain open to all as a public service.

Check out this week’s picks!
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Soft Printable Electrode Coating for Neural Interfaces
ACS Appl. Bio Mater. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acsabm.0c00401
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100th Anniversary of Macromolecular Science Viewpoint: Re-Engineering Cellular Interfaces with Synthetic Macromolecules Using Metabolic Glycan Labeling
ACS Macro Lett. 2020, 9, XXX, 991–1003
DOI: 10.1021/acsmacrolett.0c00317
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Biosynthesis, Mechanism of Action, and Inhibition of the Enterotoxin Tilimycin Produced by the Opportunistic Pathogen Klebsiella oxytoca
ACS Infect. Dis. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acsinfecdis.0c00326
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How ATP-Competitive Inhibitors Allosterically Modulate Tyrosine Kinases That Contain a Src-like Regulatory Architecture
ACS Chem. Biol. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acschembio.0c00429
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Modular Assembly of Versatile Nanoparticles with Epigallocatechin Gallate
ACS Sustainable Chem. Eng. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acssuschemeng.0c02538
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Roll-to-Roll Manufacturing of Integrated Immunodetection Sensors
ACS Sens. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acssensors.0c00404

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Silanized Liquid-Metal Nanoparticles for Responsive Electronics
ACS Appl. Nano Mater. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acsanm.0c01056
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Browse the Most-Read Articles of May 2020

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles from each ACS Publications journal in May 2020, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Click on your favorite journal below to see their most-read articles of the month.

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Accounts of Chemical Research

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Intramolecularly Cross-Linked Polymers: From Structure to Function with Applications as Artificial Antibodies and Artificial Enzymes
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.accounts.0c00178

CuH-Catalyzed Olefin Functionalization: From Hydroamination to Carbonyl Addition
DOI: 10.1021/acs.accounts.0c00164

Charge Transport in Zirconium-Based Metal–Organic Frameworks
DOI: 10.1021/acs.accounts.0c00106

Narrowing the Band Gap: The Key to High-Performance Organic Photovoltaics
DOI: 10.1021/acs.accounts.0c00157

Key References: A New Feature of Accounts
DOI: 10.1021/acs.accounts.0c00326



ACS Applied Bio Materials

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Nucleic Acids: Chemistry, Nanotechnology, and Bioapplications Forum in Honor of Professor Weihong Tan on His 60th Birthday
This article is part of the Nucleic Acids: Chemistry, Nanotechnology, and Bioapplications special issue.
DOI: 10.1021/acsabm.0c00468

Correlating Digestion-Driven Self-Assembly in Milk and Infant Formulas with Changes in Lipid Composition
Open Access through ACS AuthorChoice
DOI: 10.1021/acsabm.0c00131

Hypocrellin-Based Multifunctional Phototheranostic Agent for NIR-Triggered Targeted Chemo/Photodynamic/Photothermal Synergistic Therapy against Glioblastoma
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsabm.0c00386

Decoupling the Amplitude and Wavelength of Anisotropic Topography and the Influence on Osteogenic Differentiation of Mesenchymal Stem Cells Using a High-Throughput Screening Approach
Open Access through ACS AuthorChoice
DOI: 10.1021/acsabm.0c00330

Ultrasmall Gold Nanoparticles Cellular Uptake: Influence of Transient Bionano Interactions
DOI: 10.1021/acsabm.0c00379



ACS Applied Electronic Materials

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Manganese Doping Stabilizes Perovskite Light-Emitting Diodes by Reducing Ion Migration
Open Access through ACS AuthorChoice
DOI: 10.1021/acsaelm.0c00125

Memristive Device Characteristics Engineering by Controlling the Crystallinity of Switching Layer Materials
DOI: 10.1021/acsaelm.0c00148

Jelly-Inspired Construction of the Three-Dimensional Interconnected BN Network for Lightweight, Thermally Conductive, and Electrically Insulating Rubber Composites
DOI: 10.1021/acsaelm.0c00227

Depolarization as Driving Force in Antiferroelectric Hafnia and Ferroelectric Wake-up
DOI: 10.1021/acsaelm.0c00184

Ultrathin Ag Transparent Conducting Electrode Structure for Next-Generation Optoelectronic Applications
DOI: 10.1021/acsaelm.0c00156



ACS Applied Energy Materials

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Operando Transmission Electron Microscopy Study of All-Solid-State Battery Interface: Redistribution of Lithium among Interconnected Particles
Open Access through ACS AuthorChoice
DOI: 10.1021/acsaem.0c00543

Rapid Scalable Processing of Tin Oxide Transport Layers for Perovskite Solar Cells
Open Access through ACS AuthorChoice
DOI: 10.1021/acsaem.0c00525

Capacity Improvement by Nitrogen Doping to Lithium-Rich Cathode Materials with Stabilization Effect of Oxide Ions Redox
DOI: 10.1021/acsaem.0c00564

Syngas Evolution from CO2 Electroreduction by Porous Au Nanostructures
DOI: 10.1021/acsaem.0c00301

Exploring Lewis-Base Effects to Improve the Efficiency of [Co(bpy)3]2+/3+-Mediated Dye-Sensitized Solar Cells
Open Access through ACS AuthorChoice
DOI: 10.1021/acsaem.0c00665



ACS Applied Materials & Interfaces

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Bioinspired “Skin” with Cooperative Thermo-Optical Effect for Daytime Radiative Cooling
DOI: 10.1021/acsami.0c03897

Freezing-Tolerant, Highly Sensitive Strain and Pressure Sensors Assembled from Ionic Conductive Hydrogels with Dynamic Cross-Links
DOI: 10.1021/acsami.0c06067

Hydrophilic/Hydrophobic Heterogeneity Anti-Biofouling Hydrogels with Well-Regulated Rehydration
DOI: 10.1021/acsami.0c05406

Preface: Forum on Advances in Biocidal Materials and Interfaces
This article is part of the Advances in Biocidal Materials and Interfaces special issue.
DOI: 10.1021/acsami.0c06495

Smart Glove Integrated with Tunable MWNTs/PDMS Fibers Made of a One-Step Extrusion Method for Finger Dexterity, Gesture, and Temperature Recognition
DOI: 10.1021/acsami.0c08114



ACS Applied Nano Materials

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Manuscript Titles: How to Capture Readers and Enhance Citations
DOI: 10.1021/acsanm.0c01089

Using Site Heterogeneity in Metal–Organic Frameworks with Bimetallic Open Metal Sites for Olefin/Paraffin Separations
DOI: 10.1021/acsanm.0c00693

Controlling Pt Crystal Defects on the Surface of Ni–Pt Core–Shell Nanoparticles for Active and Stable Electrocatalysts for Oxygen Reduction
DOI: 10.1021/acsanm.0c01159

CaCl2-Activated Carbon Nitride: Hierarchically Nanoporous Carbons with Ultrahigh Nitrogen Content for Selective CO2 Adsorption
DOI: 10.1021/acsanm.0c01112

Pt Nanoparticles Supported on N-Doped Porous Carbon Derived from Metal–Organic Frameworks for Oxygen Reduction
DOI: 10.1021/acsanm.0c00906



ACS Applied Polymer Materials

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Hierarchical Photocomposition of Heteronanostructures in a Surfactant–Polysiloxane Hybrid Film toward Next-Generation Nanolithography
DOI: 10.1021/acsapm.0c00253

Flexible Polyimide Aerogels Derived from the Use of a Neopentyl Spacer in the Backbone
DOI: 10.1021/acsapm.0c00153

Surfactant-Free Latex Nanocomposites Stabilized and Reinforced by Hydrophobically Functionalized Cellulose Nanocrystals
DOI: 10.1021/acsapm.0c00263

Unprecedented Sour Mixed-Gas Permeation Properties of Fluorinated Polyazole-Based Membranes
DOI: 10.1021/acsapm.0c00196

Recyclable Polyethylene Insulation via Reactive Compounding with a Maleic Anhydride-Grafted Polypropylene
Open Access through ACS AuthorChoice
DOI: 10.1021/acsapm.0c00320



ACS Biomaterials Science & Engineering

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Special Issue: Leaders in Biomedical Engineering
This article is part of the Leaders in Biomedical Engineering special issue.
DOI: 10.1021/acsbiomaterials.0c00606

Sulfation Modulates the Targeting Properties of Hyaluronic Acid to P-Selectin and CD44
DOI: 10.1021/acsbiomaterials.0c00115

A Defined and Scalable Peptide-Based Platform for the Generation of Human Pluripotent Stem Cell-Derived Astrocytes
Open Access through ACS AuthorChoice
DOI: 10.1021/acsbiomaterials.0c00067

Antiviral and Antibacterial Nanostructured Surfaces with Excellent Mechanical Properties for Hospital Applications
DOI: 10.1021/acsbiomaterials.0c00348

Biomimetic Gelatin Methacrylate/Nano Fish Bone Hybrid Hydrogel for Bone Regeneration via Osteoimmunomodulation
DOI: 10.1021/acsbiomaterials.0c00443



ACS Catalysis

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Hydroarylation of Alkenes Using Anilines in Hexafluoroisopropanol
DOI: 10.1021/acscatal.0c00872

Catalytic β-Functionalization of Carbonyl Compounds Enabled by α,β-Desaturation
DOI: 10.1021/acscatal.0c01519

Regioselective Cross-Electrophile Coupling of Epoxides and (Hetero)aryl Iodides via Ni/Ti/Photoredox Catalysis
DOI: 10.1021/acscatal.0c01199

Development of Ketone-Based Brominating Agents (KBA) for the Practical Asymmetric α-Bromination of Aldehydes Catalyzed by Tritylpyrrolidine
DOI: 10.1021/acscatal.0c01596

Decarboxylative Hydroalkylation of Alkynes via Dual Copper-Photoredox Catalysis
DOI: 10.1021/acscatal.0c01742



ACS Central Science

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Remdesivir: A Review of Its Discovery and Development Leading to Emergency Use Authorization for Treatment of COVID-19
Open Access through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c00489

An Outlook on Low-Volume-Change Lithium Metal Anodes for Long-Life Batteries
Open Access through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c00351

Chrysomycin A Derivatives for the Treatment of Multi-Drug-Resistant Tuberculosis
Open Access through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c00122

Solution-Processed, Large-Area, Two-Dimensional Crystals of Organic Semiconductors for Field-Effect Transistors and Phototransistors
Open Access through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c00251

Let’s Make White Phosphorus Obsolete
Open Access through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c00332



ACS Chemical Biology

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When the Others Become Us: A Chemist’s Perspective of the COVID-19 Outbreak in Italy
Open Access through ACS AuthorChoice
DOI: 10.1021/acschembio.0c00289

Advancing Chemical Microbiology
This article is part of the Chemical Microbiology special issue.
DOI: 10.1021/acschembio.0c00330

Peptide Probes for Plasmodium falciparum MyoA Tail Interacting Protein (MTIP): Exploring the Druggability of the Malaria Parasite Motor Complex
Open Access through ACS AuthorChoice
DOI: 10.1021/acschembio.0c00328

Covalent Targeting of Ras G12C by Rationally Designed Peptidomimetics
DOI: 10.1021/acschembio.0c00204

Light-Driven Activation of RNA-Guided Nucleic Acid Cleavage
DOI: 10.1021/acschembio.0c00105



ACS Chemical Health & Safety

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COVID-19: A Risk Assessment Perspective
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.chas.0c00035

Getting Back to the Lab during COVID-19: Careful planning and lots of distancing are critical for R&D labs that have stayed open and those looking to restart
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.chas.0c00056

Ten Years after the Texas Tech Accident. Part II: Changing Safety Cultures and the Current State of Academic Laboratory Safety at Texas Tech University
DOI: 10.1021/acs.chas.0c00047

Development and Implementation of a Hydrofluoric Acid Safety Program in an Academic Institution
DOI: 10.1021/acs.chas.0c00008

Let’s Disagree about Safety
DOI: 10.1021/acs.chas.0c00050



ACS Chemical Neuroscience

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Expression of the SARS-CoV-2 Entry Proteins, ACE2 and TMPRSS2, in Cells of the Olfactory Epithelium: Identification of Cell Types and Trends with Age
Open Access through ACS AuthorChoice
DOI: 10.1021/acschemneuro.0c00210

Autonomic Brain Centers and Pathophysiology of COVID-19
Open Access through ACS AuthorChoice
DOI: 10.1021/acschemneuro.0c00265

Proposed Intranasal Route for Drug Administration in the Management of Central Nervous System Manifestations of COVID-19
Open Access through ACS AuthorChoice
DOI: 10.1021/acschemneuro.0c00288

NeuroChat with Dr. Karen Gregory
DOI: 10.1021/acschemneuro.0c00183

A Master Regulator of α-Synuclein Aggregation
DOI: 10.1021/acschemneuro.0c00216



ACS Combinatorial Science

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Direct, Competitive Comparison of Linear, Monocyclic, and Bicyclic Libraries Using mRNA Display
Open Access through ACS Editors’ Choice
DOI: 10.1021/acscombsci.0c00016

Targeting the Dimerization of the Main Protease of Coronaviruses: A Potential Broad-Spectrum Therapeutic Strategy
Open Access through ACS AuthorChoice
DOI: 10.1021/acscombsci.0c00058

Development of High-Throughput Methods for Sodium-Ion Battery Cathodes
DOI: 10.1021/acscombsci.9b00181

Electrochemical Screening of Metallic ORR Catalyst Thin Films Using Getter Co-Sputtering
DOI: 10.1021/acscombsci.0c00005

Scaffolding-Induced Property Modulation of Chemical Space
Open Access through ACS AuthorChoice
DOI: 10.1021/acscombsci.0c00072



ACS Earth and Space Chemistry

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Aqueous-Phase Photooxidation of Vanillic Acid: A Potential Source of Humic-Like Substances (HULIS)
DOI: 10.1021/acsearthspacechem.0c00070

Tropospheric Photo-oxidation of Ethyl Methacrylate Initiated by Cl Atoms in the Gas Phase: Kinetic and Mechanistic Investigations
DOI: 10.1021/acsearthspacechem.0c00018

Real-Time Measurements of pH Changes in Single Acoustically Levitated Droplets Due to Atmospheric Multiphase Chemistry
DOI: 10.1021/acsearthspacechem.0c00041

Impact of Hydrogen Sulfide on Photochemical Haze Formation in Methane/Nitrogen Atmospheres
DOI: 10.1021/acsearthspacechem.0c00086

Ferrous Iron Addition Decreases Methane Emissions Induced by Rice Straw in Flooded Paddy Soils
DOI: 10.1021/acsearthspacechem.0c00024



ACS Energy Letters

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COVID-19, Climate Change, and Renewable Energy Research: We Are All in This Together, and the Time to Act Is Now
Open Access through ACS AuthorChoice
DOI: 10.1021/acsenergylett.0c00910

The Role of Dimethylammonium in Bandgap Modulation for Stable Halide Perovskites
DOI: 10.1021/acsenergylett.0c00872

Stable Hexylphosphonate-Capped Blue-Emitting Quantum-Confined CsPbBr3 Nanoplatelets
Open Access through ACS AuthorChoice
DOI: 10.1021/acsenergylett.0c00935

A Robust, Scalable Platform for the Electrochemical Conversion of CO2 to Formate: Identifying Pathways to Higher Energy Efficiencies
DOI: 10.1021/acsenergylett.0c00860

CsPbBr3/ZnS Core/Shell Type Nanocrystals for Enhancing Luminescence Lifetime and Water Stability
DOI: 10.1021/acsenergylett.0c00858



ACS Infectious Diseases

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Endogenous Deficiency of Glutathione as the Most Likely Cause of Serious Manifestations and Death in COVID-19 Patients
Open Access through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.0c00288

Are Quaternary Ammonium Compounds, the Workhorse Disinfectants, Effective against Severe Acute Respiratory Syndrome-Coronavirus-2?
Open Access through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.0c00265

COVID-19: Living through Another Pandemic
Open Access through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.0c00224

The Global Antibiotic Research and Development Partnership (GARDP) Not-for-Profit Model of Antibiotic Development
DOI: 10.1021/acsinfecdis.0c00101

Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease
Open Access through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.0c00168



ACS Macro Letters

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Self-Healing Injectable Polymer Hydrogel via Dynamic Thiol-Alkynone Double Addition Cross-Links
Open Access through ACS AuthorChoice
DOI: 10.1021/acsmacrolett.0c00241

Rapid Synthesis of Elastomers and Thermosets with Tunable Thermomechanical Properties
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsmacrolett.0c00233

Vitrimerization: Converting Thermoset Polymers into Vitrimers
DOI: 10.1021/acsmacrolett.0c00299

Constructing Thermally Reversible Dynamic Hydrogels via Catalysis-Free Knoevenagel Condensation
DOI: 10.1021/acsmacrolett.0c00330

Dewar Heterocycles as Versatile Monomers for Ring-Opening Metathesis Polymerization
DOI: 10.1021/acsmacrolett.0c00227



ACS Materials Letters

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Atmospheric Water Harvesting: A Review of Material and Structural Designs
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsmaterialslett.0c00130

Controlling the Lithium-Metal Growth To Enable Low-Lithium-Metal-Excess All-Solid-State Lithium-Metal Batteries
Open Access through ACS AuthorChoice
DOI: 10.1021/acsmaterialslett.0c00152

The Origin of Dual Emission in Antiparallel-Stacked Two-Dimensional Covalent Organic Frameworks
DOI: 10.1021/acsmaterialslett.0c00119

Amorphous Multimetal Alloy Oxygen Evolving Catalysts
DOI: 10.1021/acsmaterialslett.0c00146

Highly Stable Organic Antimony Halide Crystals for X-ray Scintillation
DOI: 10.1021/acsmaterialslett.0c00133



ACS Medicinal Chemistry Letters

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Blocking Coronavirus 19 Infection via the SARS-CoV-2 Spike Protein: Initial Steps
Open Access through ACS AuthorChoice
DOI: 10.1021/acsmedchemlett.0c00233

Ligand Design for Cereblon Based Immunomodulatory Therapy
DOI: 10.1021/acsmedchemlett.0c00214

PROTAC Compounds Targeting TRK for Use in Cancer Therapeutics
DOI: 10.1021/acsmedchemlett.0c00235

PROTAC Compounds Targeting Androgen Receptor for Cancer Therapeutics: Prostate Cancer and Kennedy’s Disease
DOI: 10.1021/acsmedchemlett.0c00236

De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits
DOI: 10.1021/acsmedchemlett.0c00022



ACS Nano

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Can N95 Respirators Be Reused after Disinfection? How Many Times?
Open Access through ACS AuthorChoice
DOI: 10.1021/acsnano.0c03597

Considering the Effects of Microbiome and Diet on SARS-CoV-2 Infection: Nanotechnology Roles
Open Access through ACS AuthorChoice
DOI: 10.1021/acsnano.0c03402

Flexible Nanoporous Template for the Design and Development of Reusable Anti-COVID-19 Hydrophobic Face Masks
Open Access through ACS AuthorChoice
DOI: 10.1021/acsnano.0c03976

Leveraging Hierarchical Self-Assembly Pathways for Realizing Colloidal Photonic Crystals
Open Access through ACS AuthorChoice
DOI: 10.1021/acsnano.9b07849

Melbourne—Australia’s Science City
DOI: 10.1021/acsnano.0c04003



ACS Omega

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Advanced Mechanochemistry Device for Sustainable Synthetic Processes
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c00521

Cobalt Colloid-derived Efficient and Durable Nanoscale Electrocatalytic Films for High-Activity Water Oxidation
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.9b03576

Rapid Detection of IgM Antibodies against the SARS-CoV-2 Virus via Colloidal Gold Nanoparticle-Based Lateral-Flow Assay
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c01554

Carbazole/Benzimidazole-Based Bipolar Molecules as the Hosts for Phosphorescent and Thermally Activated Delayed Fluorescence Emitters for Efficient OLEDs
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c00967

Mechanistic Insights into Zika Virus NS3 Helicase Inhibition by Epigallocatechin-3-Gallate
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c01353



ACS Pharmacology & Translational Science

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Characterization of the Core Ribosomal Binding Region for the Oxazolidone Family of Antibiotics Using Cryo-EM
DOI: 10.1021/acsptsci.0c00041

Rapid and Point-of-Care Testing in Respiratory Tract Infections: An Antibiotic Guardian?
Open Access through ACS AuthorChoice
DOI: 10.1021/acsptsci.0c00027

Modulation of Lymphocyte Potassium Channel KV1.3 by Membrane-Penetrating, Joint-Targeting Immunomodulatory Plant Defensin
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsptsci.0c00035

Physiologically-based population pharmacokinetic modeling approach for ciprofloxacin in bone of patients undergoing orthopedic surgery
DOI: 10.1021/acsptsci.0c00045



ACS Photonics

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Microwave Programmable Graphene Metasurface
DOI: 10.1021/acsphotonics.9b01807

Design of Selective Reflectors Utilizing Multiple Scattering by Core–Shell Nanoparticles for Color Conversion Films
DOI: 10.1021/acsphotonics.0c00117

Photonic Nanojet Mediated Backaction of Dielectric Microparticles
DOI: 10.1021/acsphotonics.0c00242

Metasurface Generation of Paired Accelerating and Rotating Optical Beams for Passive Ranging and Scene Reconstruction
DOI: 10.1021/acsphotonics.0c00354

Quantum-Memory-Enabled Ultrafast Optical Switching in Carbon Nanotubes
DOI: 10.1021/acsphotonics.0c00315



ACS Sensors

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Giants in Sensing: A Virtual Issue to Celebrate Five Years of ACS Sensors
DOI: 10.1021/acssensors.0c00875

Epidermal Enzymatic Biosensors for Sweat Vitamin C: Toward Personalized Nutrition
DOI: 10.1021/acssensors.0c00604

Detect to Protect
Open Access through ACS AuthorChoice
DOI: 10.1021/acssensors.0c00920

Virus Detection: What Were We Doing before COVID-19 Changed the World?
Open Access through ACS AuthorChoice
DOI: 10.1021/acssensors.0c01029

Sequence-Specific Recognition of HIV-1 DNA with Solid-State CRISPR-Cas12a-Assisted Nanopores (SCAN)
DOI: 10.1021/acssensors.0c00497



ACS Sustainable Chemistry & Engineering

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Functionalization of Nitrogen-Doped Carbon Nanofibers with Polyamidoamine Dendrimer as a Freestanding Electrode with High Sulfur Loading for Lithium–Polysulfides Batteries
DOI: 10.1021/acssuschemeng.0c00300

Worthy and Necessary Challenges
DOI: 10.1021/acssuschemeng.0c02881

Methanol-Based Chain Elongation with Acetate to n-Butyrate and Isobutyrate at Varying Selectivities Dependent on pH
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.0c00907

Efficient and Easily Reusable Metal-Free Heterogeneous Catalyst Beads for the Conversion of CO2 into Cyclic Carbonates in the Presence of Water as Hydrogen-Bond Donor
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.0c02265

Perspective on Technical Lignin Fractionation
DOI: 10.1021/acssuschemeng.0c01348



ACS Symposium Series

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A Polymer Physics Perspective on Why PEI Is an Effective Nonviral Gene Delivery Vector
DOI: 10.1021/bk-2020-1350.ch001

Preface
DOI: 10.1021/bk-2020-1350.pr001

Cellular Delivery of Hoechst 33342 Anticancer Drug from Crosslinked Poly(thioether anhydrides): A Cytotoxicity and Efficacy Study
DOI: 10.1021/bk-2020-1350.ch006

Recent Advancements in Arrayed Technologies and Emerging Themes in the Identification of Glycan-Protein Interactions
DOI: 10.1021/bk-2020-1346.ch001

Metal–Organic Nanomaterials for Drug Delivery
DOI: 10.1021/bk-2020-1350.ch007



ACS Synthetic Biology

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Automated Continuous Evolution of Proteins in Vivo
DOI: 10.1021/acssynbio.0c00135

Bottom-Up Construction of a Minimal System for Cellular Respiration and Energy Regeneration
Open Access through ACS AuthorChoice
DOI: 10.1021/acssynbio.0c00110

High-Throughput Screening for Substrate Specificity-Adapted Mutants of the Nisin Dehydratase NisB
Open Access through ACS AuthorChoice
DOI: 10.1021/acssynbio.0c00130

Cell-Free Bacteriophage Genome Synthesis Using Low-Cost Sequence-Verified Array-Synthesized Oligonucleotides
DOI: 10.1021/acssynbio.0c00051

Two-Component Biosensors: Unveiling the Mechanisms of Predictable Tunability
DOI: 10.1021/acssynbio.0c00010



Analytical Chemistry

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Real-Time In-Organism NMR Metabolomics Reveals Different Roles of AMP-Activated Protein Kinase Catalytic Subunits
DOI: 10.1021/acs.analchem.9b05670

Paper-Based Constant Potential Electrochemiluminescence Sensing Platform with Black Phosphorus as a Luminophore Enabled by a Perovskite Solar Cell
DOI: 10.1021/acs.analchem.0c01033

MicroRNA-Initiated and Intracellular Na+-Fueled DNAzyme Motor for Differentiating Molecular Subtypes of Nonsmall Cell Lung Cancer
DOI: 10.1021/acs.analchem.0c01134

Sub-zeptomole Detection of Biomarker Proteins Using a Microfluidic Immunoarray with Nanostructured Sensors
DOI: 10.1021/acs.analchem.0c01507

“Switch-On” Fluorescence Detection of Glucose with High Specificity and Sensitivity Based on Silver Nanoparticles Supported on Porphyrin Metal–Organic Frameworks
DOI: 10.1021/acs.analchem.0c01651



Biochemistry

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A Jumbo Phage Forms a Nucleus-like Compartment to Evade Bacterial Defense Systems
DOI: 10.1021/acs.biochem.0c00273

Dimeric Stilbene Antibiotics Target the Bacterial Cell Wall in Drug-Resistant Gram-Positive Pathogens
DOI: 10.1021/acs.biochem.0c00213

Probing the Conformational Changes Associated with DNA Binding to PARP1
DOI: 10.1021/acs.biochem.0c00256

Global Profiling of Cellular Substrates of Human Dcp2
DOI: 10.1021/acs.biochem.0c00069

Evidence of an Unusual Poly(A) RNA Signature Detected by High-Throughput Chemical Mapping
DOI: 10.1021/acs.biochem.0c00215



Bioconjugate Chemistry

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Precise Installation of Diazo-Tagged Side-Chains on Proteins to Enable In Vitro and In-Cell Site-Specific Labeling
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.bioconjchem.0c00232

Conjugated Protein Domains as Engineered Scaffold Proteins
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.bioconjchem.0c00183

Fluorescent Labeling of Proteins of Interest in Live Cells: Beyond Fluorescent Proteins
DOI: 10.1021/acs.bioconjchem.0c00181

An Artificial Amphiphilic Peptide Promotes Endocytic Uptake by Inducing Membrane Curvature
DOI: 10.1021/acs.bioconjchem.0c00239

In Situ One-Step Fluorescence Labeling Strategy of Exosomes via Bioorthogonal Click Chemistry for Real-Time Exosome Tracking In Vitro and In Vivo
DOI: 10.1021/acs.bioconjchem.0c00216



Biomacromolecules

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Injectable Antimicrobial Conductive Hydrogels for Wound Disinfection and Infectious Wound Healing
DOI: 10.1021/acs.biomac.9b01732

Renewable Molecules & Materials: Anselme Payen Award Symposium in Honor of Ann-Christine Albertsson
DOI: 10.1021/acs.biomac.0c00507

Synthesis of Zwitterionic and Trehalose Polymers with Variable Degradation Rates and Stabilization of Insulin
DOI: 10.1021/acs.biomac.0c00133

Functionalization of Cellulose Nanocrystals with POEGMA Copolymers via Copper-Catalyzed Azide–Alkyne Cycloaddition for Potential Drug-Delivery Applications
DOI: 10.1021/acs.biomac.9b01713

Chiral Nematic Liquid Crystal Behavior of Core–Shell Hybrid Rods Consisting of Chiral Cellulose Nanocrystals Dressed with Non-chiral Conformal Polymeric Skins
DOI: 10.1021/acs.biomac.0c00320



C&EN Global Enterprise

***

Hair color chemistry gets a fresh look
DOI: 10.1021/cen-09817-cover

Getting back to the lab during COVID-19
DOI: 10.1021/cen-09819-cover

Advancing sustainability in the pharmaceutical industry
DOI: 10.1021/cen-09817-comment

Rethinking the role of blood pressure drugs in COVID-19
DOI: 10.1021/cen-09820-cover

Navigating the coronavirus job crisis
DOI: 10.1021/cen-09818-cover



Chemical Research in Toxicology

***

Advanced In Vitro Testing Strategies and Models of the Intestine for Nanosafety Research
DOI: 10.1021/acs.chemrestox.0c00079

Special Issue on “Future Nanosafety”
This article is part of the Future Nanosafety special issue.
DOI: 10.1021/acs.chemrestox.0c00166

Ensemble Models Based on QuBiLS-MAS Features and Shallow Learning for the Prediction of Drug-Induced Liver Toxicity: Improving Deep Learning and Traditional Approaches
DOI: 10.1021/acs.chemrestox.0c00030

Interactions of Perfluorooctanesulfonate and 6:2 Chlorinated Polyfluorinated Ether Sulfonate with Human Serum Albumin: A Comparative Study
DOI: 10.1021/acs.chemrestox.0c00075

Arsenic Exposure and Compromised Protein Quality Control
DOI: 10.1021/acs.chemrestox.0c00107



Chemical Reviews

***

Metal–Organic Framework-Based Catalysts with Single Metal Sites
DOI: 10.1021/acs.chemrev.9b00757

Water and Metal–Organic Frameworks: From Interaction toward Utilization
Open Access Through ACS AuthorChoice
This article is part of the Porous Framework Chemistry special issue.
DOI: 10.1021/acs.chemrev.9b00746

Bioprinting: From Tissue and Organ Development to in Vitro Models
Open Access Through ACS AuthorChoice
This article is part of the 3D Printing for Biomaterials special issue.
DOI: 10.1021/acs.chemrev.9b00789

Functional Supramolecular Polymeric Networks: The Marriage of Covalent Polymers and Macrocycle-Based Host–Guest Interactions
DOI: 10.1021/acs.chemrev.9b00839

Activation of Dinitrogen by Polynuclear Metal Complexes
DOI: 10.1021/acs.chemrev.0c00042



Chemistry of Materials

***

Mechanochemical Grafting: A Solvent-less Highly Efficient Method for the Synthesis of Hybrid Inorganic–Organic Materials
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.chemmater.0c01266

Uncovering the Role of Metal–Organic Framework Topology on the Capture and Reactivity of Chemical Warfare Agents
DOI: 10.1021/acs.chemmater.0c00986

Continuous Nucleation and Size Dependent Growth Kinetics of Indium Phosphide Nanocrystals
DOI: 10.1021/acs.chemmater.0c01561

All-Lignin-Based Hydrogel with Fast pH-Stimuli Responsiveness for Mechanical Switching and Actuation
DOI: 10.1021/acs.chemmater.0c01198

Highly Emissive Semi-Ladder-Type Copolymers, Aggregation State, and Solution-Processed Organic Light-Emitting Transistor
DOI: 10.1021/acs.chemmater.0c01168



Crystal Growth & Design

***

Recognition-Control and Host–Guest Interactions in High-Symmetry Cocrystals of Fullerenes with Cubane and Mesitylene
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.cgd.0c00440

Temperature-Dependent Supramolecular Isomeric Zn(II)-Metal–Organic Frameworks and Their Guest Exchange
DOI: 10.1021/acs.cgd.0c00443

Bottom-Up Growth of Shape-Engineered Molecular Single Crystals
DOI: 10.1021/acs.cgd.0c00194

Tuning Physicochemical Properties of Antipsychotic Drug Aripiprazole with Multicomponent Crystal Strategy Based on Structure and Property Relationship
DOI: 10.1021/acs.cgd.0c00022

Generation and Evaluation of Pharmacologically Relevant Drug–Drug Cocrystal for Gout Therapy
DOI: 10.1021/acs.cgd.0c00106



Energy & Fuels

***

Laminar Burning Velocities and Kinetic Modeling of a Renewable E-Fuel: Formic Acid and Its Mixtures with H2 and CO2
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.energyfuels.0c00944

Overview of Asphaltene Nanostructures and Thermodynamic Applications
DOI: 10.1021/acs.energyfuels.0c00874

Efficient Depolymerization of Alkaline Lignin to Phenolic Compounds at Low Temperatures with Formic Acid over Inexpensive Fe–Zn/Al2O3 Catalyst
DOI: 10.1021/acs.energyfuels.0c00742

Microwave-Assisted Dry and Bi-reforming of Methane over M–Mo/TiO2 (M = Co, Cu) Bimetallic Catalysts
DOI: 10.1021/acs.energyfuels.0c00757

Recovery of Hydrogen and Sulfur by Electrolysis of Ionized H2S in an Amine-Containing Organic Electrolyte with Highly Temperature-Dependent Sulfur Solubility
DOI: 10.1021/acs.energyfuels.0c01161



Environmental Science & Technology

***

Potential Sensitivity of Wastewater Monitoring for SARS-CoV-2: Comparison with Norovirus Cases
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.est.0c02271

An (Eco)Toxicity Life Cycle Impact Assessment Framework for Per- And Polyfluoroalkyl Substances
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.est.9b07774

Retrospective Risk Assessment of Chemical Mixtures in the Big Data Era: An Alternative Classification Strategy to Integrate Chemical and Toxicological Data
DOI: 10.1021/acs.est.0c01062

Evolving Today to Best Serve Tomorrow
DOI: 10.1021/acs.est.0c02360

Balancing Privacy Rights and the Production of High-Quality Satellite Imagery
DOI: 10.1021/acs.est.0c02365



Environmental Science & Technology Letters

***

Exotic Electrophiles in Chlorinated and Chloraminated Water: When Conventional Kinetic Models and Reaction Pathways Fall Short
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.estlett.0c00259

Substantial Changes in Nitrogen Dioxide and Ozone after Excluding Meteorological Impacts during the COVID-19 Outbreak in Mainland China
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.estlett.0c00304

Presence of SARS-Coronavirus-2 RNA in Sewage and Correlation with Reported COVID-19 Prevalence in the Early Stage of the Epidemic in The Netherlands
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.estlett.0c00357

μ-MIP: Molecularly Imprinted Polymer-Modified Microelectrodes for the Ultrasensitive Quantification of GenX (HFPO-DA) in River Water
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.estlett.0c00341

Observational Evidence for the Involvement of Dicarboxylic Acids in Particle Nucleation
DOI: 10.1021/acs.estlett.0c00270



Industrial & Engineering Chemistry Research

***

Chemical Degradation of End-of-Life Poly(lactic acid) into Methyl Lactate by a Zn(II) Complex
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.iecr.0c01122

OHM Sponge: A Versatile, Efficient, and Ecofriendly Environmental Remediation Platform
DOI: 10.1021/acs.iecr.0c01493

Novel Adsorption Process for Co-Production of Hydrogen and CO2 from a Multicomponent Stream—Part 2: Application to Steam Methane Reforming and Autothermal Reforming Gases
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.iecr.9b06953

Electro-Enhanced Membrane Sorption: A New Approach for Selective Ion Separation and Its Application to Phosphate and Arsenic Removal
DOI: 10.1021/acs.iecr.0c01498

Zeolitic Imidazolate Framework-67-Derived CeO2@Co3O4 Core–Shell Microspheres with Enhanced Catalytic Activity toward Toluene Oxidation
DOI: 10.1021/acs.iecr.9b07028



Inorganic Chemistry

***

A Safe Return
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.inorgchem.0c01253

Enhanced Water Dispersibility of Discrete Chalcogenide Nanoclusters with a Sodalite-Net Loose-Packing Pattern in a Crystal Lattice
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.inorgchem.0c00621

Ruthenium 4d-to-2p X-ray Emission Spectroscopy: A Simultaneous Probe of the Metal and the Bound Ligands
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.inorgchem.0c00663

Forcing Dicyanamide Coordination to f-Elements by Dissolution in Dicyanamide-Based Ionic Liquids
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.inorgchem.0c00667

Alkyne Functionalization of a Photoactivated Ruthenium Polypyridyl Complex for Click-Enabled Serum Albumin Interaction Studies
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.inorgchem.0c00742



Journal of Agricultural and Food Chemistry

***

Occurrence and Fate of Natural Estrogens in Swiss Cattle and Pig Slurry
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jafc.0c00858

Investigation of Chocolate Matrix Interference on Cannabinoid Analytes
DOI: 10.1021/acs.jafc.0c01161

Discovery of Tryptanthrins as Novel Antiviral and Anti-Phytopathogenic-Fungus Agents
DOI: 10.1021/acs.jafc.0c02101

Hepatic Lipidomics Analysis Reveals the Antiobesity and Cholesterol-Lowering Effects of Tangeretin in High-Fat Diet-Fed Rats
DOI: 10.1021/acs.jafc.0c01778

Protective Mechanism of Common Buckwheat (Fagopyrum esculentum Moench.) against Nonalcoholic Fatty Liver Disease Associated with Dyslipidemia in Mice Fed a High-Fat and High-Cholesterol Diet
DOI: 10.1021/acs.jafc.9b08211



Journal of Chemical & Engineering Data

***

Nuclear Magnetic Resonance (NMR) Spectroscopy for the In Situ Measurement of Vapor–Liquid Equilibria
Open Access Through ACS AuthorChoice
This article is part of the Nontraditional Techniques for Measurement of Phase Equilibria special issue.
DOI: 10.1021/acs.jced.0c00113

Isobaric Vapor–Liquid Equilibria for Binary Mixtures of Biomass-Derived γ-Valerolactone + Tetrahydrofuran and 2-Methyltetrahydrofuran
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jced.0c00084

Heat of Adsorption: A Comparative Study between the Experimental Determination and Theoretical Models Using the System CH4-MOFs
DOI: 10.1021/acs.jced.0c00159

Development of Multivalent Metal-Ion-Fabricated Fumaric Acid-Based Metal–Organic Frameworks for Defluoridation of Water
DOI: 10.1021/acs.jced.0c00005

Entropy Scaling of Viscosity—I: A Case Study of Propane
DOI: 10.1021/acs.jced.0c00209



Journal of Chemical Education

***

An Arduino-Based Talking Calorimeter for Inclusive Lab Activities
DOI: 10.1021/acs.jchemed.0c00148

Establishing the Laboratory as the Place to Learn How to Do Chemistry
DOI: 10.1021/acs.jchemed.9b00764

Chemistry Education in Times of Disruption and the Times That Lie Beyond
DOI: 10.1021/acs.jchemed.0c00377

Writing the 2019 ACS Exam for Chemical Health and Safety
This article is part of the Chemical Safety Education: Methods, Culture, and Green Chemistry special issue.
DOI: 10.1021/acs.jchemed.0c00124

Development of a Large-Enrollment Course-Based Research Experience in an Undergraduate Organic Chemistry Laboratory: Structure–Function Relationships in Pyrylium Photoredox Catalysts
DOI: 10.1021/acs.jchemed.9b00786



Journal of Chemical Information and Modeling

***

Scope of 3D Shape-Based Approaches in Predicting the Macromolecular Targets of Structurally Complex Small Molecules Including Natural Products and Macrocyclic Ligands
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jcim.0c00161

ADME Prediction with KNIME: Development and Validation of a Publicly Available Workflow for the Prediction of Human Oral Bioavailability
DOI: 10.1021/acs.jcim.0c00019

Matched Molecular Series Analysis for ADME Property Prediction
DOI: 10.1021/acs.jcim.0c00269

Practical Considerations for Atomistic Structure Modeling with Cryo-EM Maps
DOI: 10.1021/acs.jcim.0c00090

Loop Grafting between Similar Local Environments for Fc-Silent Antibodies
Open Access Through ACS AuthorChoice
This article is part of the Novel Directions in Free Energy Methods and Applications special issue.
DOI: 10.1021/acs.jcim.9b01198



Journal of Chemical Theory and Computation

***

Determining Free-Energy Differences Through Variationally Derived Intermediates
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.0c00106

Restricted-Variance Molecular Geometry Optimization Based on Gradient-Enhanced Kriging
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.0c00257

Coarse-Grained Molecular Model for the Glycosylphosphatidylinositol Anchor with and without Protein
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.0c00056

Validation of Pseudopotential Calculations for the Electronic Band Gap of Solids
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.0c00214

Protein Structure Prediction in CASP13 Using AWSEM-Suite
DOI: 10.1021/acs.jctc.0c00188



Journal of Medicinal Chemistry

***

A Fast and Clean BTK Inhibitor
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jmedchem.0c00597

Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein
DOI: 10.1021/acs.jmedchem.0c00471

Learning Molecular Representations for Medicinal Chemistry Miniperspective
DOI: 10.1021/acs.jmedchem.0c00385

Discovery of BMS-986235/LAR-1219: A Potent Formyl Peptide Receptor 2 (FPR2) Selective Agonist for the Prevention of Heart Failure
DOI: 10.1021/acs.jmedchem.9b02101

Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor
DOI: 10.1021/acs.jmedchem.0c00406



Journal of Natural Products

***

A DNA Repair Inhibitor Isolated from an Ecuadorian Fungal Endophyte Exhibits Synthetic Lethality in PTEN-Deficient Glioblastoma
DOI: 10.1021/acs.jnatprod.0c00012

Inhibitory Effect of Cannabidiol on the Activation of NLRP3 Inflammasome Is Associated with Its Modulation of the P2X7 Receptor in Human Monocytes
DOI: 10.1021/acs.jnatprod.0c00138

Review of Progress in the Chemistry of Organic Natural Products
DOI: 10.1021/acs.jnatprod.0c00356

Selective Chlorophyll Removal Method to “Degreen” Botanical Extracts
DOI: 10.1021/acs.jnatprod.0c00005

Streptomyces albogriseolus SY67903 Produces Eunicellin Diterpenoids Structurally Similar to Terpenes of the Gorgonian Muricella sibogae, the Bacterial Source
DOI: 10.1021/acs.jnatprod.0c00147



Journal of Proteome Research

***

Deciphering the Proteome Dynamics during Development of Neurons Derived from Induced Pluripotent Stem Cells
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jproteome.0c00070

His-Tagged Peptidiscs Enable Affinity Purification of the Membrane Proteome for Downstream Mass Spectrometry Analysis
DOI: 10.1021/acs.jproteome.0c00022

Stable Isotope-Triggered Offset Fragmentation Allows Massively Multiplexed Target Profiling on Quadrupole-Orbitrap Mass Spectrometers
DOI: 10.1021/acs.jproteome.0c00065

Physiological Tau Interactome in Brain and Its Link to Tauopathies
DOI: 10.1021/acs.jproteome.0c00137

Relative and Quantitative Phosphoproteome Analysis of Macrophages in Response to Infection by Virulent and Avirulent Mycobacteria Reveals a Distinct Role of the Cytosolic RNA Sensor RIG-I in Mycobacterium tuberculosis Pathogenesis
DOI: 10.1021/acs.jproteome.9b00895



Journal of the American Chemical Society

***

Nickel-Catalyzed Cross-Electrophile Coupling of Aryl Chlorides with Primary Alkyl Chlorides
DOI: 10.1021/jacs.0c02673

Chemical Equivalent of Arene Monooxygenases: Dearomative Synthesis of Arene Oxides and Oxepines
DOI: 10.1021/jacs.0c02724

Nucleophilic (Radio)Fluorination of Redox-Active Esters via Radical-Polar Crossover Enabled by Photoredox Catalysis
DOI: 10.1021/jacs.0c03125

Synthesis of Pyrroles through the CuH-Catalyzed Coupling of Enynes and Nitriles
DOI: 10.1021/jacs.0c03859

Organophotoredox Hydrodefluorination of Trifluoromethylarenes with Translational Applicability to Drug Discovery
Open Access Through ACS AuthorChoice
DOI: 10.1021/jacs.0c03881



Journal of the American Society for Mass Spectrometry

***

Kenneth G. Standing (April 3, 1925–March 21, 2019)
DOI: 10.1021/jasms.0c00049

Don’t Stop Thinking about Tomorrow
DOI: 10.1021/jasms.0c00170

Solvent Adducts in Ion Mobility Spectrometry: Toward an Alternative Reaction Probe for Thermometer Ions
DOI: 10.1021/jasms.0c00108

Direct Analysis of Doping Agents in Raw Urine Using Hydrophobic Paper Spray Mass Spectrometry
DOI: 10.1021/jasms.0c00063

Quantitative Proteomic Analysis of MARC-145 Cells Infected with a Mexican Porcine Reproductive and Respiratory Syndrome Virus Strain Using a Label-Free Based DIA Approach
DOI: 10.1021/jasms.0c00134



Langmuir

***

Hofmeister Series for Metal-Cation–RNA Interactions: The Interplay of Binding Affinity and Exchange Kinetics
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.langmuir.0c00851

Effects of Amino Acids on Iron-Silicate Chemical Garden Precipitation
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.langmuir.0c00502

Compression, Rupture, and Puncture of Model Membranes at the Molecular Scale
DOI: 10.1021/acs.langmuir.0c00247

Colloidal Photonic Assemblies for Colorful Radiative Cooling
DOI: 10.1021/acs.langmuir.0c00051

Surfactant-Free One-Pot Synthesis of Homogeneous Trimetallic PtNiCu Nanoparticles with Size Control by Using Glycine
DOI: 10.1021/acs.langmuir.0c00665



Macromolecules

***

The Beauty of Branching in Polymer Science
DOI: 10.1021/acs.macromol.0c00286

Tough Supramolecular Elastomer via Entropy-Driven Hydrogen Bonds between Vicinal Diols
DOI: 10.1021/acs.macromol.9b02639

Harnessing Strained Disulfides for Photocurable Adaptable Hydrogels
DOI: 10.1021/acs.macromol.0c00604

Precise Control of Molecular Weight and Stereospecificity in Lewis Pair Polymerization of Semifluorinated Methacrylates: Mechanistic Studies and Stereocomplex Formation
DOI: 10.1021/acs.macromol.0c00553

Polyethylene Containing Triblock Copolymers Synthesized by Post-polymerization Functionalization
DOI: 10.1021/acs.macromol.0c00627



Molecular Pharmaceutics

***

Emerging Biomolecular Testing to Assess the Risk of Mortality from COVID-19 Infection
Open Access Through ACS AuthorChoice
This article is part of the Nanomedicines Beyond Cancer special issue.
DOI: 10.1021/acs.molpharmaceut.0c00371

Transdermal Drug Delivery for Hair Regrowth
DOI: 10.1021/acs.molpharmaceut.0c00041

TLR7/8 Agonist-Loaded Nanoparticles Augment NK Cell-Mediated Antibody-Based Cancer Immunotherapy
DOI: 10.1021/acs.molpharmaceut.0c00271

Combined Application of Albumin-Binding [177Lu]Lu-PSMA-ALB-56 and Fast-Cleared PSMA Inhibitors: Optimization of the Pharmacokinetics
DOI: 10.1021/acs.molpharmaceut.0c00199

Intranasal Delivery and Transfection of mRNA Therapeutics in the Brain Using Cationic Liposomes
DOI: 10.1021/acs.molpharmaceut.0c00170



Nano Letters

***

Nanobowl-Supported Liposomes Improve Drug Loading and Delivery
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.nanolett.0c00495

Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.nanolett.0c01386

One-Dimensional Edge Transport in Few-Layer WTe2
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.nanolett.0c00658

Exciting Journey from the 0D to the 2D Nanoworld
DOI: 10.1021/acs.nanolett.0c01077

Hybrid Biodegradable Nanomotors through Compartmentalized Synthesis
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.nanolett.0c01268



Organic Letters

***

Electrochemical Ruthenium-Catalyzed C–H Hydroxylation of Amine Derivatives in Aqueous Acid
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.orglett.0c01313

Designing Homogeneous Copper-Free Sonogashira Reaction through a Prism of Pd–Pd Transmetalation
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.orglett.0c01227

Total Synthesis of (±)-Sceptrin
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.orglett.0c01381

A General One-Pot Protocol for Hindered N-Alkyl Azaheterocycles from Tertiary Carboxylic Acids
DOI: 10.1021/acs.orglett.0c01254

Hidden Boron Catalysis: Nucleophile-Promoted Decomposition of HBpin
DOI: 10.1021/acs.orglett.0c01168



Organic Process Research & Development

***

Some Items of Interest to Process R&D Chemists and Engineers
DOI: 10.1021/acs.oprd.0c00197

Potential Explosion Hazards Associated with the Autocatalytic Thermal Decomposition of Dimethyl Sulfoxide and Its Mixtures
DOI: 10.1021/acs.oprd.0c00159

A Taste of Current French Organic Chemistry
This article is part of the A Taste of Current French Organic Chemistry special issue.
DOI: 10.1021/acs.oprd.0c00095

Continuous Process for Preparing the Difluoromethylating Reagent [(DMPU)2Zn(CF2H) 2] and Improved Synthesis of the ICHF2 Precursor
DOI: 10.1021/acs.oprd.0c00089

Applications of Flow Chemistry in the Pharmaceutical Industry—Highlights of the Recent Patent Literature
DOI: 10.1021/acs.oprd.0c00156



Organometallics

***

Synthesis, Structures, and Electronic Properties of O- and S-Heterocyclic Carbene Complexes of Iridium, Copper, Silver, and Gold
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.organomet.0c00066

Organometallic Chemistry for Enabling Carbon Dioxide Utilization
This article is part of the Organometallic Chemistry for Enabling Carbon Dioxide Utilization special issue.
DOI: 10.1021/acs.organomet.0c00229

An Update on Multiple Bonding between Heavier Main Group Elements: The Importance of Pauli Repulsion, Charge-Shift Character, and London Dispersion Force Effects
DOI: 10.1021/acs.organomet.0c00200

Nickel-Catalyzed Alkyne Cyclotrimerization Assisted by a Hemilabile Acceptor Ligand: A Computational Study
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.organomet.0c00172

One-Electron Reduction of Ti(IV) Complex by Dialkylaluminum(I) Anion Giving the Ti(III) Species
DOI: 10.1021/acs.organomet.0c00177



The Journal of Organic Chemistry

***

Recent Advances in Synthetic Methods for Radioiodination
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.joc.0c00644

One-Pot Suzuki-Hydrogenolysis Protocol for the Modular Synthesis of 2,5-Diaryltetrazoles
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.joc.0c00807

Total Synthesis of Cinnamodial-Based Dimer (−)-Capsicodendrin
DOI: 10.1021/acs.joc.0c00740

Cp*Co(III)-Catalyzed Ketone-Directed ortho-C–H Activation for the Synthesis of Indene Derivatives
DOI: 10.1021/acs.joc.0c00727

Metal-Free Synthesis of Phenol-Aryl Selenides via Dehydrogenative C–Se Coupling of Aryl Selenoxides with Phenols
DOI: 10.1021/acs.joc.0c00792



The Journal of Physical Chemistry A

***

Memorial Viewpoint for William L. Hase
DOI: 10.1021/acs.jpca.0c03827

Novel Computer Architectures and Quantum Chemistry
DOI: 10.1021/acs.jpca.0c02249

Ring-Current Maps for Benzenoids: Comparisons, Contradictions, and a Versatile Combinatorial Model
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpca.0c02748

Correlation of Photoluminescence and Structural Morphologies at the Individual Nanoparticle Level
Open Access Through ACS AuthorChoice
This article is part of the Time-Resolved Microscopy virtual special issue.
DOI: 10.1021/acs.jpca.0c02340

Highly Conjugated, Fused-Ring, Quadrupolar Organic Chromophores with Large Two-Photon Absorption Cross-Sections in the Near-Infrared
DOI: 10.1021/acs.jpca.0c02572



The Journal of Physical Chemistry B

***

Theoretical Insights into the Excited State Decays of a Donor–Acceptor Dyad: Is the Twisted and Rehybridized Intramolecular Charge-Transfer State Involved?
DOI: 10.1021/acs.jpcb.0c02455

Universal and Nonuniversal Aspects of Electrostatics in Aqueous Nanoconfinement
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.0c01967

Quantifying Protein-Protein Interactions in Molecular Simulations
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.9b11802

Remarkable Levels of 15N Polarization Delivered through SABRE into Unlabeled Pyridine, Pyrazine, or Metronidazole Enable Single Scan NMR Quantification at the mM Level
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.0c02583

RNAPosers: Machine Learning Classifiers for Ribonucleic Acid–Ligand Poses
DOI: 10.1021/acs.jpcb.0c02322



The Journal of Physical Chemistry C

***

Substrate-Dependent Exciton Diffusion and Annihilation in Chemically Treated MoS2 and WS2
DOI: 10.1021/acs.jpcc.0c04000

Luminescence Line Broadening of CdSe Nanoplatelets and Quantum Dots for Application in w-LEDs
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.0c03048

Elucidation of the Active Sites for Monodisperse FePt and Pt Nanocrystal Catalysts for p-WSe2 Photocathodes
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.0c01288

How the Nature of the Alkali Metal Cations Influences the Double Layer Capacitance of Cu, Au and Pt Single Crystal Electrodes
DOI: 10.1021/acs.jpcc.0c01715

Structural Stability of Physisorbed Air-Oxidized Decanethiols on Au(111)
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.0c02806



The Journal of Physical Chemistry Letters

***

Self-Healing Dyes—Keeping the Promise?
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jpclett.9b03833

In Silico Exploration of the Molecular Mechanism of Clinically Oriented Drugs for Possibly Inhibiting SARS-CoV-2’s Main Protease
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.0c00994

Novel Coronavirus Polymerase and Nucleotidyl-transferase Structures: Potential to Target New Outbreaks
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.0c00571

Resolving Spectral Mismatch Errors for Perovskite Solar Cells in Commercial Class AAA Solar Simulators
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.0c00355

Combining Graphics Processing Units, Simplified Time-Dependent Density Functional Theory, and Finite-Difference Couplings to Accelerate Nonadiabatic Molecular Dynamics
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.0c00320

The New Faces of Crystal Growth & Design

Earlier this year, Jonathan W. Steed was named the new Editor-in-Chief of Crystal Growth & Design. Alongside Steed, the journal has welcomed several new editors to the team as well. New editors bring new experiences, perspectives, and ideas to the journal. Get to know some of the latest new Crystal Growth & Design team members.

This year, the journal added five new Topic Editors and one new Associate Editor. Learn about the differences between the two roles and meet new faces leading the journal in the interviews below.


TOPIC EDITORS

Topic Editors are paired together with Associate Editors, and the pairs work together to manage manuscripts. The Topic-Associate Editor pair allows topic editors to learn the intricacies of the editorial review process.


Dr. Doris E. Braun

Doris E. Braun is a Senior Scientist at the Universität Innsbruck, Institute of Pharmacy in Austria. Dr. Doris started her two-year Topic Editor term this January.

What is your research focus? What initially attracted you to your field?

The “Preformulation and Polymorphism group” at the University of Innsbruck focuses on scientific and applied problems related to solid-state properties of pharmaceuticals and other small organic molecules of high industrial relevance. We develop methods, strategies, and guidelines for the production and characterization of solid-state forms. Based on our systematic explorations of structure-property relationships, we work toward understanding the factors leading to multiple crystal forms, including polymorphs, hydrates, solvates, co-crystals.

Particularly, my research focuses on:

1)the role of computational chemistry for (pharmaceutical) solid form screening and characterization: how to implement crystal structure prediction into solid form screening and characterization programs

2) thermodynamic relations in solid forms: how to derive the thermodynamic stability order of different solid-state forms

3)the important solid form class of hydrates (water adducts): prediction, characterization and practical consequences of hydrate formation

As an undergraduate student, I became familiar with solid-state problems of organic/drug compounds, and the phenomenon of polymorphism fascinated me. My high interest in this research area made me decide to proceed scientifically in this field.

What do you hope to bring to your journal?

Materials properties and their applicability have always been the driving force in my research. This is due to my university training in pharmacy and time working on projects focusing on basic research and industrial problems. Furthermore, as a scientist, I have taken the role of an experimentalist among world-leading theoretical chemists, and am now applying computational chemistry in an otherwise experimentally focused research group. Hence, my scientific path shaped me to address problems by complementing theoretical and experimental approaches and combining different research areas. Therefore, I am hoping that my experience will further strengthen the excellent team of CG&D and that together we can promote out of the box thinking of scientists and engineers working in the field and foster new young talents.

What are the major challenges facing your field today?

Over the last decade, there have been ground-breaking changes in the research field of “polymorphism.” Computational chemistry can be used to predict feasible crystal structures of small pharmaceuticals from the molecular geometry alone as a starting point. Experimental techniques have advanced that intermediate solid forms can be detected and even structurally characterized. High-resolution data collections allow us to get insights into the structural behavior and interrelations of solid-state forms. Thus, the challenges we have to overcome in our field are often not related to the science but are linked to the accessibility of the (newest) techniques, the time we can spend working on a compound, and the funding opportunities available.

What do you think is the most interesting and/or important unsolved problem in your field?

Despite the ground-breaking advances in the field and the efforts undertaken by scientists in academia and industry worldwide, we are still not able to predict if a molecule will crystallize, let alone in what forms or under which conditions. The required breakthrough is probably understanding nucleation and growth in practically relevant systems. The ultimate goal is then to design and produce the assembly of new materials with targeted properties.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Inconvenient Truths about Solid Form Landscapes Revealed in the Polymorphs and Hydrates of Gandotinib
Cryst. Growth Des. 2019, 19, 5, 2947–2962
DOI: 10.1021/acs.cgd.9b00162

The extensive experimental and computational study highlights the current state of the art in the solid-state characterization of crystal forms of a flexible drug molecule. It also reveals many inconvenient truths about solid form landscapes and the effort that is sometimes required to identify solid forms, characterize their properties, and determine when it is appropriate to discontinue solid form screening. This understanding of drug molecules’ solid-state landscape was only achieved through the efforts of experimentalists and theoreticians working in industry and academia.

Professor Peter Crowley

Professor Peter Crowley of the National University of Ireland – Galway started his two-year Topic Editor term this January. His research focus is protein assembly, and he hopes to bring a new focus on proteins to the journal. “Currently, only about 15 % of the material in Crystal Growth & Design is concerned with proteins. There is an interesting interface between the fields of supramolecular chemistry and protein science. The Crystal Growth & Design community can contribute greatly to this space,” he says.

What is your research focus?

What initially attracted you to your field? Our main focus is protein assembly. We use macrocycles such as calixarenes and cucurbiturils to direct protein assembly and crystallization. Our initial interest was to characterize protein surface recognition by macrocycles. It turned out that calixarenes are rather effective mediators of assembly or “molecular glues”.

What do you hope to bring to your journal?

I hope to bring a new focus on proteins. Currently, only about 15 % of the material in Crystal Growth and Design is concerned with proteins. There is an interesting interface between the fields of supramolecular chemistry and protein science. The Crystal Growth and Design community can contribute greatly to this space.

What are the major challenges facing your field today?

The major challenge is the lack of resources, particularly funding opportunities for Ph. D. and postdoctoral researchers. Specific to the field – controlled protein assembly remains an outstanding question. There are many approaches, but often these are specific to a given system/protein. Another major issue is the cost barrier to the manufacture of protein-based materials.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Tuning Protein Frameworks via Auxiliary Supramolecular Interactions
ACS Nano 2019, 13, 9, 10343–10350
DOI: 10.1021/acsnano.9b04115

I wish to highlight our recent work in ACS Nano. In this paper, we showed how “classical” supramolecular chemistry can be used to modulate porous protein assemblies or frameworks.

Professor Shuang-Quan Zang

Professor Shuang-Quan Zang of Zhengzhou University began his two-year Topic Editor term this January.

What is your research focus? What initially attracted you to your field?

Metal clusters, Metal-organic framework, Crystal engineering. The fascinating crystal color and morphology attracted me.

What do you hope to bring to the journal?

I want to expand the journal’s influence in Asia, especially among Chinese researchers.

What are the major challenges facing your field today?

The major challenge in metal clusters may be the functionalization and application.

What do you think is the most interesting and/or important unsolved problem in your field?

The most interesting may be the chirality of metal clusters.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Assembly of Atomically Precise Silver Nanoclusters into Nanocluster-Based Frameworks
J. Am. Chem. Soc. 2019, 141, 24, 9585–9592
DOI: 10.1021/jacs.9b02486

Metal cluster-assembled materials are a main research field.

Anything else you’d like readers to know?

My ORCID is here. I would like readers to know more about the College of Chemistry at Zhengzhou University.

Dr. Xin Zhang

Dr. Xin Zhang is a chemist at the Pacific Northwest National Laboratory

What is your research focus?

Crystal growth, surface science, and material synthesis for the environment, energy, and catalysis. Building nanostructures have been widely embraced as a strategy to control the chemical and physical properties of materials, which attracted me to work in this field.

What do you hope to bring to the journal?

Encourage researchers to publish high-quality papers and attract more audiences.

What are the major challenges facing your field today?

Major challenges include:

  • Imaging the solution, ion, and surface structures that create the forces to drive the cluster/particle aggregation.
  • Size, shape and facet-controlled synthesis of nanocrystals via additive-free methods
  • Design and develop novel nanomaterials via machine learning coupled high throughput experimentation
  • Directly imaging the nucleation at the atomic level
  • Directly imaging the crystallization in extreme environments, such as high temperature, high pressure, radiation, and ultra-low/high pH

What do you think is the most interesting and/or important unsolved problem in your field?

The solution, ion, and surface structures that create the forces that drive the cluster/particle aggregation.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Cr(III) Adsorption by Cluster Formation on Boehmite Nanoplates in Highly Alkaline Solution
Environ. Sci. Technol. 2019, 53, 18, 11043–11055
DOI: 10.1021/acs.est.9b02693

Professor Hai-Bo Yang

Professor Hai-Bo Yang of East China Normal University started his two-year Topic Editor term this January.

What is your research focus? What initially attracted you to your field?

My research interests focus on supramolecular chemistry, especially supramolecular self-assembly, supramolecular polymers, and rotaxane dendrimers. I am always fascinated by the beauty of the biological self-assembly in Nature, and I am very curious whether we can use the great power of chemical self-assembly towards the construction of complex matters with intriguing properties and wide applications.

What do you hope to bring to the journal?

I hope that some concepts and approaches in supramolecular self-assembly will appear in Crystal Growth & Design. Actually, in some cases, the crystal growth and design are inspired by non-covalent interactions in supramolecular self-assembly.

What are the major challenges facing your field today?

Although supramolecular self-assembly has developed well during the past few decades, there are still many challenges in this field. For example, it is still very difficult to realize well-controlled self-assembly towards complex matters in the lab. Moreover, it is still challenging to set up a bridge between the fundamental research and practical applications of supramolecular self-assembly.

What do you think is the most interesting and/or important unsolved problem in your field?

How to realize the hierarchical self-assembly towards the controllable and programable construction of complex matters with predicted properties and functions at different scales.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Cation–Anion Arrangement Patterns in Self-Assembled Pd2L4 and Pd4L8 Coordination Cages
Acc. Chem. Res. 2017, 50, 9, 2233–2243
DOI: 10.1021/acs.accounts.7b00231

Recently, my group has published an account in Accounts of Chemical Research, in which we summarized our expedition in the construction of stimuli-responsive functional materials via hierarchical self-assembly involving coordination interactions.

Anything else you’d like readers to know?

I like listening to some Chinese traditional music in my spare time. Moreover, I enjoy learning about cultures from different places in the world when I travel abroad.

Professor Helena J. Shepherd

Professor Helena J. Shepherd of the University of Kent is the journal’s newest Topic Editor, joining the CGD team just last month.

What is your research focus? What initially attracted you to your field?

My research group at the University of Kent, U.K., focuses on stimuli-responsive molecular materials in the solid-state. We are interested in a range of systems, from organometallic complexes that switch their spin state in response to changes in temperature, pressure, light, etc. to organic photoswitches that undergo dramatic changes in color and structure. I have group members working on many different aspects of these materials, including synthesis and scale-up processes, detailed structure-property correlations, and the development of new applications. I think what attracts me to these materials is the huge capacity for atomic and molecular motion, even in the solid-state. The ability to gain a fundamental understanding of these dynamic processes is vital to their development, but exploiting them for real-world applications is the next big challenge that keeps me coming back to these beautiful materials.

What do you hope to bring to your journal?

I have a background in structural chemistry but have used a lot of different techniques not only to understand the link between structure and properties but also in efforts to control it. I would like to use this opportunity at Crystal Growth and Design to demonstrate just how active – and exciting – molecular materials can be.

What are the major challenges facing your field today?

Anisotropy in molecular materials makes understanding cooperative processes such as phase transitions very difficult – properties arise as a complex combination of both intramolecular bonding and intermolecular interactions. Furthermore, we are increasingly finding that useful properties often arise not from the bulk of a material, but from surfaces, defects, and dynamic processes that occur at very small length scales. It is very difficult to see beyond the bulk using traditional structural techniques, and so these fundamentally important details are lost. I think these major challenges are inherently linked to huge opportunities – developments in traditional experimental hardware and advances in techniques such as electron diffraction mean we are no longer restricted to observation of the average structure of a material. I look forward to seeing how far we can go in understanding the world – in all its complexity – down to the atomic scale

What do you think is the most interesting and/or important unsolved problem in your field?

Designing new responsive molecular materials with specific properties tuned to any given technological application and operating conditions.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Complete Set of Elastic Moduli of a Spin-Crossover Solid: Spin-State Dependence and Mechanical Actuation
J. Am. Chem. Soc. 2018, 140, 28, 8970–8979
DOI: 10.1021/jacs.8b05347

Understanding anisotropic mechanical properties and processes will be increasingly important as we employ more molecular materials in advanced technologies. This paper is the result of a large collaboration between chemists, physicists, and materials scientists seeking to understand the mechanical properties of spin-crossover systems, led by colleagues at the LCC-CNRS in Toulouse, France. By combining nuclear inelastic scattering, high-pressure single-crystal X-ray diffraction, and micromechanical resonance experiments, we were able to obtain a complete characterization of the elastic properties of the molecular compound. These measurements reveal a relatively stiff molecular lattice, which displays a pronounced, anisotropic softening upon the transition from low- to high-spin. These different characteristics are correlated with the strong cooperativity (of elastic origin) observed in some spin crossover materials and also allowed for the assessment of the actuating performance of thin films of such materials. As such, this work paves the way for the effective integration of spin crossover complexes into mechanical actuators and also provides a better understanding of the electron−lattice coupling, which to a large extent governs the spin crossover properties.


ASSOCIATE EDITORS

Associate Editors focus on a broader range of topics when handling manuscripts.


Dr. Len Barbour

Dr. Len Barbour is a Distinguished Professor at the University of Stellenbosch.

What is your research focus? What initially attracted you to the field?

I am interested in all aspects of solid-state supramolecular chemistry, but particularly with regard to shedding light on structure-property relationships. My main focus is on the characterization of porous crystalline materials. I am attracted to this area because porosity at the molecular level is an unusual, even counterintuitive phenomenon. Molecules prefer to pack efficiently, which leaves little space for accommodating small guest species. However, we are learning how to overcome close-packing tendencies, thereby creating a vast library of new porous materials that can be tuned for various applications involving molecular recognition.

What do you hope to bring to the journal?

Crystal Growth and Design is arguably already the top journal in the rapidly-growing field of crystal engineering. I hope to play an integral part in maintaining the high standards of the journal, also helping to attract articles that explore new and exciting directions in the area.

What are the major challenges facing your field today?

I am certainly an advocate of exploratory research aimed at bettering our understanding of how and why materials behave the way that they do – i.e., relating structure and function. In fact, most of my own research is focused on exploring molecular space without necessarily having a commercial application in mind every time. However, one of the most difficult leaps in any field is to recognize how an intellectually interesting phenomenon might be put to good use. I believe that the biggest challenge in the field of crystal engineering is to take the next step by translating tuneable properties into useful devices. This requires imagination that transcends the rigorous training that scientists usually receive.

What do you think is the most important and/or interesting unsolved problem in your field? Crystal structure prediction has come a long way in the past two decades. I believe that we are heading towards a future where structures and their properties will be predicted as a matter of routine.

Do you have a recent paper from an ACS journal that you would like to highlight?

Record-Setting Selectivity for p-Xylene by an Intrinsically Porous Zero-Dimensional Metallocycle
J. Am. Chem. Soc. 2020, 142, 10, 4529–4533
DOI: 10.1021/jacs.9b11314

We have been exploring discrete dinuclear metallocycles as the building blocks of porous materials for the past 15 years. These are conceptually donut-shaped metal complexes that are capable of stacking in the solid-state such that their ‘holes’ line up to form channels. Sometimes these channels aren’t continuous, but the concerted motion of the flexible metallocycles can cause neighboring holes to merge fleetingly, thus creating transient pores. The structural flexibility of the material allows the pores to adapt to small guest molecules according to their size and shape, with the possibility of recognizing one isomer in a mixture. We demonstrated that one of our metallocycles exhibits record-setting selectivity for the commercially important para-xylene from a mixture of the three xylene isomers. In fact, the material is even capable of removing para-xylene from commercially pure (>99%) ortho-xylene.

Anything else you’d like readers to know about you?

Had I not become a chemist, I would probably have been an engineer. I am deeply interested in woodwork, metalwork, electronics, and software development. In addition to being satisfying hobbies, these interests have been immensely helpful in developing new research tools to facilitate my work.

Meet the entire Crystal Growth & Design team.

Watch Selected Methods/Protocol Videos from ACS Biomaterials Science & Engineering

Since 2018, ACS Biomaterials Science & Engineering has partnered with Chemistry of Materials to produce an annual Virtual Issue on Methods and Protocols in Materials Science. Papers that can help others reproduce published results by providing details of methods and lab techniques employed to attain those results are highly valued since they can help propel research forward. Towards this goal, the 2018 and 2019 Virtual Issues focused on publishing methods and protocols papers that described new and/or improvised approaches to studying and solving important challenges in materials science.

Video is an important tool for describing and demonstrating how to accurately carry out lab methods and protocols. Many of the published papers in the 2018 and 2019 Virtual Issues included supplemental videos that displayed in detail the techniques used in these reported methods/protocols.

Watch these featured videos and read the papers highlighted below.

ACS Biomaterials Science & Engineering Methods/Protocols related to above Supplemental Videos

Simple and Convenient Method for the Isolation, Culture, and Re-collection of Cancer Cells from Blood by Using Glass-Bead Filters
ACS Biomater. Sci. Eng. 2019, 5, 2, 438–452
DOI:10.1021/acsbiomaterials.8b01335

Metabolic Glycoengineering of Cell-Derived Matrices and Cell Surfaces: A Combination of Key Principles and Step-by-Step Procedures
ACS Biomater. Sci. Eng. 2019, 5, 1, 215–233
DOI: 10.1021/acsbiomaterials.8b00865

3D Printing of Neural Tissues Derived from Human Induced Pluripotent Stem Cells Using a Fibrin-Based Bioink
ACS Biomater. Sci. Eng. 2019, 5, 1, 234–243
DOI: 10.1021/acsbiomaterials.8b01235

Isolation and Identification of Proteins Secreted by Cells Cultured within Synthetic Hydrogel-Based Matrices
ACS Biomater. Sci. Eng. 2018, 4, 3, 836–845
DOI: 10.1021/acsbiomaterials.7b00647

Methods To Assess Shear-Thinning Hydrogels for Application As Injectable Biomaterials
ACS Biomater. Sci. Eng. 2017, 3, 12, 3146–3160
DOI: 10.1021/acsbiomaterials.7b00734

Tutorials for Electrophysiological Recordings in Neuronal Tissue Engineering
ACS Biomater. Sci. Eng. 2017, 3, 10, 2235–2246
DOI: 10.1021/acsbiomaterials.7b00318

Predicting Silk Fiber Mechanical Properties through Multiscale Simulation and Protein Design
ACS Biomater. Sci. Eng. 2017, 3, 8, 1542–1556
DOI: 10.1021/acsbiomaterials.7b00292

Surface Analysis of Nanocomplexes by X-ray Photoelectron Spectroscopy (XPS)
ACS Biomater. Sci. Eng. 2017, 3, 6, 882–889
DOI: 10.1021/acsbiomaterials.7b00040

Nanoscience and Nanotechnology Research Highlights for Nano Korea 2020

Due to ongoing concerns about COVID-19, the 18th International Nano Technology Exhibition, Korea Nano 2020, will be a hybrid online and offline event, happening between July 1-3, 2020. The in-person portion of this premier global nanotechnology and nanoscience conference, which is sponsored by South Korea’s Ministry of Science & ICT and the Ministry of Trade, Industry & Energy, will be held at the KINTEX Exhibition Center in Goyang.

Ahead of this important conference, please enjoy these recent highlighted research collections from selected ACS Publications journals that are focused on nanoscience and nanotechnology.

ACS Nano

Nano Research for COVID-19
The nanoscience and nanotechnology community can contribute significantly to the fight against COVID-19. Gathered here are some of the most recent articles, published in ACS Nano, that utilize nanoscience and nanotechnology to address this global challenge.

Nanoscience and Nanotechnology at the Korea Advanced Institute of Science and Technology
Korea Advanced Institute of Science and Technology (KAIST) has actively contributed to ACS Nano and the fields of nanoscience and nanotechnology. In this Virtual Issue, you can find highlighted papers published in ACS Nano by KAIST researchers over the past 8 years.

ACS Applied Nano Materials

A New Era of Metal-Organic Framework Nanomaterials and Applications
This virtual issue highlights publications from ACS Applied Nano Materials on the topic of applied MOF-based nanomaterials research.

Spotlights and Reviews
Short on time and need a quick read? Explore the latest spotlight and review articles from ACS Applied Nano Materials.

Nano Letters

Viewpoints

These are invited, one-page opinion pieces intended to be forward-looking and highlight emerging focus areas that are beneficial to the nanoscience community.

Chasing Plasmons in Flatland

This virtual issue focuses on the most recent advances in the coupling between the field of plasmonics and 2D materials that were published in Nano Letters in the past decade.

Share Your Feedback on ACS’ Continued Efforts to Fight Racism and Bias in Chemistry

As the world’s leading society publisher, we have a responsibility to aggressively combat bias in the publishing process.

In addition to the actions set out in this editorial, the editors-in-chief of all ACS Publications journals encourage the broad chemistry community to join in this ongoing conversation. Share your ideas about how we can improve our journals to be more diverse and inclusive. We are listening carefully.

Share Your Feedback

Additional Reading:

Call for Papers: Special Issue on Psychedelics for Treating Mental Illness

ACS Pharmacology & Translational Science plans to publish a special issue titled “Psychedelics: New Advances in Preclinical & Clinical Studies” in early 2021. Assistant Professor David Olson, University of California, Davis, Department of Chemistry and Department of Biochemistry & Molecular Medicine, is the guest editor for the special issue and invites you to submit a manuscript by November 15, 2020.

“Psychiatry is desperate,” says Olson, “and it is clear that if we ever hope to cure mental illness, we need to embrace truly innovative treatment approaches. The use of psychedelics in medicine could be a boon, as these drugs have shown promise for producing both rapid and long-lasting therapeutic effects across multiple neuropsychiatric disorders. Studies using these powerful drugs in combination with the tools of modern science will undoubtedly provide new insights into brain function, and hopefully, get us closer to finding effective medicines for depression, post-traumatic stress disorder, and substance use disorder.”

What to Submit—Deadline: November 15, 2020

“We’re looking for cutting-edge preclinical and human clinical data with psychedelic drugs,” says ACS Pharmacology & Translational Science Editor-in-Chief Craig Lindsley. “Without question, the resurgence of psychedelics represents the most exciting neurotherapeutic area in decades!”

Areas of particular interest include:

  • The effects of psychedelics in preclinical models of brain disorders
  • Detailed pharmacological and/or DPMK characterization of known and designer psychedelics
  • New insights into the molecular mechanisms of psychedelics
  • Human clinical data with psychedelics

Articles, Letters, Reviews, Perspectives, and Viewpoints are all welcome. For details on requirements for each manuscript type, please consult the Author Guidelines. You can also find the entire ACS Pharmacology & Translational Science scope below.

ACS Pharmacology & Translational Science Scope

ACS Pharmacology & Translational Science publishes high-quality, innovative research across the broad spectrum of biological sciences—from basic and molecular sciences to translational preclinical studies. Its editors also consider clinical studies that address novel mechanisms of action and methodological papers that provide innovation and advance translation.

The journal’s editors give priority to studies that fully integrate basic pharmacological and/or biochemical findings into physiological processes that have translational potential in a broad range of biomedical disciplines. Therefore, studies that employ a complementary blend of in vitro and in vivo systems are of particular interest, but they will consider all innovative research with articulated translational relevance.

ACS Pharmacology and Translational Science does not publish research on biological extracts that have unknown concentration or unknown chemical composition.

If you have questions about the scope and/or about publishing in ACS Pharmacology & Translational Science, please contact Editor-in-Chief Craig Lindsley at eic@ptsci.acs.org.

 

Spotlight on I&EC Research’s Associate Editors from China

Industrial & Engineering Chemistry Research has been at the forefront of chemical engineering research since 1909. Because of the immense impact that researchers in China have had on the journal, Chinese Associate Editors and Editorial Advisory Board members now represent more than one-third of the team. This group works alongside Editor-in-Chief Phillip E. Savage to publish widely-read articles and provide high-quality peer review and fast times to decision.

For the past several years, I&EC Research’s manuscript submissions, published articles, and citations, and various publication parameters, such as the Clarivate Analytics Impact Factor, have continued to rise. The readership, submissions, and impact of researchers from China are significant contributors to these trends.

The journal is delighted to introduce the community to five Associate Editors from China. We look forward to future opportunities to convene at scientific conferences around the world, creating opportunities for members of the I&EC Research editorial team to engage with authors, reviewers, and readers.

Take a few minutes getting to know these members of the I&EC Research editorial board:

Professor Xinbin Ma


What is the biggest challenge you’re facing when returning to reopen your lab?

I want to make sure every member of my lab is healthy, both physically and mentally.

Tell me about your area of research. How did your interest in this area first develop?

The group’s research area focuses on syngas utilization and CO2 capture and utilization. Take syngas utilization as an example. Given the abundance of coal resources in China, it is important to develop a green technology for the conversion of coal-based syngas into bulk chemicals. My early research focused on the synthesis of oxalate and its downstream products such as ethylene glycol from syngas, which has a huge market demand in China. Through many years’ efforts, my team developed a highly competitive catalytic technology for the production of ethylene glycol that was successfully applied in a pilot plant.

What do you think is the most interesting or important unsolved problem in the field of chemical engineering?

From my viewpoint, the most interesting problem is the development of a green chemical process that can meet the demand of the present and future generations for various chemical products and meanwhile benefit the environment and society.

What advice would you give to someone who wanted to pursue a career in chemical engineering?

The field of chemical engineering offers many different avenues for building a career. Whether working to design new chemical processes, develop new plants, or overseeing operations of a facility or doing education and lab research, individuals with a career interest in chemical engineering can find their roles in these areas. It quite depends on personal interests and circumstances. In general, good education and training that fits the career goal are required. This helps to master the necessary skills, learning the tools and technology for the career, and build personal strength.

What is the best piece of advice you have ever received? How has it helped your career?

“No cohesion, no team.” In scientific research, teams are central to the work. Without cohesion in the team members, without efforts focusing on the same goal, a lot of things could not have been made when scaling the coal-based syngas to ethylene glycol technology from the lab scale to the commercial scale.

How has I&EC Research had an impact on your research?

I&EC Research is the largest, oldest, and most cited chemical engineering research journal in the world. The journal covers industrial and academic research in the broad fields of applied chemistry and chemical engineering with a special focus on fundamentals, processes, and products. During my research career, reading the I&EC Research articles has inspired me to think about a lot of new ideas, no matter if they work or not in the end. Meanwhile, it is a channel to get to know peers who work in the same field. The publication of papers in I&EC Research has given us a chance to demonstrate our research work to others. All of these have a positive impact on career development and progress.

Read Some of His Research in ACS Publications Journals

Influence of Acid Strength on the Reactivity of Dimethyl Ether Carbonylation over H-MOR
ACS Sustainable Chemistry & Engineering 2019, 7, 2, 2027-2034
DOI: 10.1021/acssuschemeng.8b04388
***
Deactivation Kinetics for the Carbonylation of Dimethyl Ether to Methyl Acetate on H-MOR
Industrial & Engineering Chemistry Research 2017, 56, 46, 13618-13627
DOI: 10.1021/acs.iecr.7b03500
***
Balancing Effect between Adsorption and Diffusion on Catalytic Performance Inside Hollow Nanostructured Catalyst
ACS Catalysis 2019, 9, 4, 2969-2976
DOI: 10.1021/acscatal.9b00282

Professor Feng-Shou Xiao

What is the biggest challenge you’ve faced in reopening your lab?

The biggest challenge is to preserve the safety of the students and to avoid the virus. In addition, the progress of scientific research is also important, because we have lost the past several months.

Tell me about your area of research. How did your interest in this area first develop?

My research is focused on the green synthesis of zeolites and the development of heterogeneous catalysts. My interest is in developing sustainable routes for the synthesis of zeolites because of the large amount of water and organic template that are used in the conventional synthesis of zeolite catalysts. In the past 20 years, we developed organic template-free and solvent-free strategies for the synthesis of zeolites. Furthermore, the organic template-free synthesis of Beta and ZSM-22 zeolites has been scaled up for industrial production. Recently, we are working to prepare zeolite-metal nanoparticle hybrid catalysts by fixing the metal nanoparticles within zeolite crystals, which has obvious advantages in the activity, selectivity, and durability, compared with general supported catalysts.

What do you think is the most interesting or important unsolved problem in the field of chemical engineering?

Using cheap and earth-abundant carbon resources such as methane and carbon dioxide, as well as the ethane and propane, to produce valuable chemicals. A lot of research studies have been focused on this field, but the efficacy goal remains unmet and still requires new ideas in the design of catalysts and reaction processes.

What advice would you give to someone who wanted to pursue a career in chemical engineering?

Focus on the most important things and keep going! Don’t give up easily.

What is the best piece of advice you have ever received?

New ideas usually result from the reconsideration of experiments. Put in the hard work to do more experiments.

How has I&EC Research had an impact on your research?

I&EC Research publishes both industrial and fundamental research, which are very helpful for my group members and me to get the latest research information, particularly in the fields of applied chemistry.

Read Some of His Research in ACS Publications Journals

Green Routes for Synthesis of Zeolites
Chemical Reviews 2014, 114, 2, 1521-1543
DOI: 10.1021/cr4001513
***
Cobalt–Nickel Catalysts for Selective Hydrogenation of Carbon Dioxide into Ethanol
ACS Catalysis 2019, 9, 12, 11335-11340
DOI: 10.1021/acscatal.9b04187
***
Solvent-Free Synthesis of Core–Shell Zn/ZSM-5@Silicalite-1 Catalyst for Selective Conversion of Methanol to BTX Aromatics
Industrial & Engineering Chemistry Research 2019, 58, 34, 15453-15458
DOI: 10.1021/acs.iecr.9b03357

Professor Huanting Wang

How did you cope during your university’s recent closure for COVID-19?

It has been quite challenging during our university’s recent closure in response to the COVID-19 pandemic. I am an experimentalist, and the lab shutdown simply means that all projects suddenly stop. I have managed to stay positive and spend more time reading papers, thinking about some new ideas, and revising manuscripts. I have had regular meetings via online platforms with my students and postdocs to share my experience in living with this difficult situation, and encourage them to be still active in research, and making progress in their projects. Most importantly, my group members are all safe, well, and optimistic about our future.

What is the biggest challenge you expect to face when returning to reopen your lab?

We will face some challenges. We will still need to maintain the social distancing rules for (at least) many months ahead. The biggest challenge is that we will need to work in the labs efficiently while ensuring everyone’s safety and well-being. But we have been well-prepared and will get through this challenging time together.

Tell me about your area of research. How did your interest in this area first develop?

My area of research is membranes and functional materials for efficient separations (gas separation, water desalination and purification, chiral separation, and lithium extraction and recovery) and electrochemical energy applications (fuel cells and hydrogen production). My interest in this area was first developed when I was doing my master’s degree at the University of Science and Technology of China, where there is strong research is being done in these areas.

What do you think is the most interesting or important unsolved problem in the field of chemical engineering?

This is a big question, and people certainly have different views on this. To me, the most interesting unsolved problem in the field of chemical engineering is how to construct separation systems to manipulate molecular and ionic transport at the nano- to sub-nano- levels and thus achieve highly efficient separations and enable advanced renewable energy technologies.

What advice would you give to someone who wanted to pursue a career in chemical engineering?

The chemical engineering field has become much broader than ever before, which means it interfaces with anything you would like to do in the future. I am open-minded and interact with people in different fields. Cross-disciplinary knowledge often leads to exciting ideas that impact chemical engineering.

What is the best piece of advice you have ever received? How has it helped your career?

I have been privileged to have the opportunity to work with so many people and have received a lot of great advice that helped my career development. One piece of advice is that you need to remember to think about the next step, beyond what you are currently doing. This has motivated me along different stages of my career.

How has I&EC Research had an impact on your research?

I&EC Research is one of the best journals in the field — a must-see resource for chemical engineering and related fields. I have been reading this journal since my master’s study. I have enjoyed so much publishing and reviewing with I&EC Research, and my research has greatly benefited from this journal.

Read Some of His Research in ACS Publications Journals

Voltage-Gated Ion Transport in Two-Dimensional Sub-1 nm Nanofluidic Channels
ACS Nano 2019, 13, 10, 11793-11799
DOI: 10.1021/acsnano.9b05758
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Robust Thermoresponsive Polymer Composite Membrane with Switchable Superhydrophilicity and Superhydrophobicity for Efficient Oil–Water Separation
Environmental Science & Technology 2016, 50, 2, 906-914
DOI: 10.1021/acs.est.5b03418
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Improvement of the Swelling Properties of Ionic Hydrogels by the Incorporation of Hydrophobic, Elastic Microfibers for Forward Osmosis Applications
Industrial & Engineering Chemistry Research 2017, 56, 2, 505-512
DOI: 10.1021/acs.iecr.6b03689

Professor Bo Geng Li


How did you cope during your university’s recent closure for COVID-19?

We have launched online teaching, academic discussions, and conferences. With the financial support of the university, all teachers’ home broadband has been upgraded.

What is the biggest challenge you’re facing when returning to reopen your lab?

It is taking much longer to buy reagents or equipment for the lab, especially when those items must be imported from other countries.

Tell me about your area of research.

My research area is polymer product engineering. When I read papers in the field of polymers, I often find that with the same raw materials and cost input, products with different performance can be obtained. I think the precise customization of polymeric structures is very important in the polymerization process. Digital manufacturing of mechanical industrial products has a history that is several decades long. 3D printing has realized the digital manufacturing of polymer products with specific shapes, but the mechanical properties of 3D printing parts have not yet reached the level of traditional polymer parts because of the difference in the molecular and aggregate structures. In my research, we are exploring if the molecular and aggregate structures of polymers can be digitally manufactured.

What do you think is the most interesting or important unsolved problem in the field of chemical engineering?

Digital manufacturing of structured chemicals such as polymers, i.e., precisely customizing structured chemicals based on computer programmed approaches.

What is the best piece of advice you have ever received? How has it helped your career?

The best piece of advice I have ever received from my supervisor is “Teach undergraduate students because they have no frame of reference, so they will ask you many challenging questions.” I’m constantly growing my knowledge from these types of challenging questions.

How has I&EC Research had an impact on your research?

I&EC Research is like a think tank, which provides a lot of research inspiration. It is a stage to share the joys of research success amongst peers.

Read Some of His Research in ACS Publications Journals

The Epoxidation of Polybutadiene via Reaction-Controlled Phase-Transfer Catalysis
Industrial & Engineering Chemistry Research 2019, 58, 29, 13085-13092
DOI: 10.1021/acs.iecr.9b02371
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Modification of Poly(ethylene 2,5-furandicarboxylate) with Biobased 1,5-Pentanediol: Significantly Toughened Copolyesters Retaining High Tensile Strength and O2 Barrier Property
Biomacromolecules 2019, 20, 1, 353-364
DOI: 10.1021/acs.biomac.8b01495
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CO2-Triggered Recoverable Metal Catalyst Nanoreactors using Unimolecular Core–Shell Star Copolymers as Carriers
ACS Applied Nano Materials 2018, 1, 3, 1280-1290
DOI: 10.1021/acsanm.8b00031

Professor Youqing Shen

How did you cope during your university’s recent closure for COVID-19?

I worked at home reading, writing, and planning. I read to learn the basics and the most recent research progress of an area I recently got interested in: cancer immunotherapy. I discussed with my students via WeChat about their recent results and made detailed plans for each project.

What is the biggest challenge you’re facing when returning to reopen your lab?

We want to ensure the students’ safety and remain cautious of persons carrying the virus that do not show symptoms. I have asked my students to wear masks as often as possible and to stay on campus.

Tell me about your area of research. How did your interest in this area first develop?

My research area is in biomedical materials or polymers, particularly for cancer drug delivery and cancer immunotherapy. My interest in this area originated from a dream of being a doctor. So, when I started my own group at the University of Wyoming, I started to use my polymer chemistry background to solve biomedical problems.

What advice would you give to someone who wanted to pursue a career in chemical engineering?

To be a good chemical engineer, make your math and chemistry knowledge base solid during your undergraduate study.

What is the best piece of advice you have ever received? How has it helped your career?

When I just started my career, my friend Professor Maciej Radosz shared this advice: “Chase problems rather than chase funding.” This really helped me focus during my early career development, when various funding opportunities may easily lure you to chase them.

Read Some of His Research in ACS Publications Journals

Enzyme-Triggered Transcytosis of Dendrimer–Drug Conjugate for Deep Penetration into Pancreatic Tumors
ACS Nano 2020, 14, 4, 4890-4904
DOI: 10.1021/acsnano.0c00974
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Enzyme-Responsive Charge-Reversal Polymer-Mediated Effective Gene Therapy for Intraperitoneal Tumors
Biomacromolecules 2018, 19, 6, 2308-2319
DOI: 10.1021/acs.biomac.8b00440
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Biocompatible Cyclodextrin-Based Metal–Organic Frameworks for Long-Term Sustained Release of Fragrances

Industrial & Engineering Chemistry Research 2019, 58, 43, 19767-19777
DOI: 10.1021/acs.iecr.9b04214

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Read Highlighted Articles from Chinese Authors in I&EC Research

ACS Synthetic Biology Young Innovator Award Goes to Dr. Albert J. Keung

ACS Synthetic Biology is pleased to announce Dr. Albert J. Keung as this year’s recipient of the 2020 ACS Synthetic Biology Young Innovator Award.

Dr. Albert J. Keung graduated with his bachelor’s in chemical engineering from Stanford University in 2006. He then went on to earn his Ph.D. in chemical engineering at the University of California, Berkeley, in 2012 under Professors David Schaffer and Sanjay Kumar. Dr. Keung then became an NIH Ruth Kirschstein postdoctoral fellow working with Professors James Collins and Ahmad Khalil.

Dr. Keung started his research group at North Carolina State University in 2016 where his research spans the fields of synthetic biology, epigenome engineering, and neuroengineering. He is particularly interested in the sophisticated ways information can be naturally or artificially stored in chromatin and DNA, as well as in addressing the related neuroepigenetic underpinnings of brain disorders. His group’s work has been recognized and supported by the NIH NIDA Avenir Award, NSF EFRI, Simons Foundation, and the Foundation for Angelman Syndrome Therapeutics for which Dr. Keung also serves on the scientific advisory board.

I caught up with Dr. Keung to find out more about his career to date.

How did you first become interested in studying synthetic biology, and in particular DNA-Based Information Storage Systems?

I came to synthetic biology through epigenetics. My Ph.D. was focused on stem cell engineering, and given the importance of epigenetics in stem cell biology, in my reading, I came across some really creative work in the chromatin biology field from the likes of Danesh Moazed and Tom Muir and others. They probably wouldn’t characterize their work as synthetic biology, but they had used really clever non-typical molecular biology, biochemistry, and cell biology approaches to answer tough mechanistic questions. I began reading more in the area, and my mentors pointed me towards the literature in the synthetic biology field. That’s when I found Pamela Silver, Michael Elowitz, Jim Collins, and others’ decades of work in the field, and I was hooked.

How would you describe your research to someone outside your field of research?

I would describe DNA-based information storage as fundamentally rethinking how data is stored. Instead of thinking about data organized or arrayed spatially in specific spots on a spinning hard drive, a tape drive, or a DVD/CD, there can actually be much gained from storing information in mixtures of molecules like DNA. Even though it is disordered and sloshing around everywhere, it is this very nature of molecular mixtures from which one could gain considerable advantages such as being able to store the world’s information inside a single shoebox or perform computations on data in highly parallelized manners almost like having trillions of microprocessors.

In terms of our epigenome engineering work, I often explain the epigenome or chromatin as a powerful ‘layer’ of information on top of DNA. It controls when and how information in our genome is accessed, much like a program calling lines from software code. We are interested in understanding what that programming is, but also how to manipulate and harness it.

If the previous two areas of our group are very appealing to me intellectually, our work in neuroengineering is perhaps the most emotional. There are significant suffering and hardship in the human condition, with much of the most persistent and drawn-out struggles being neurological in nature, including neurodevelopmental disorders to addiction to neurodegenerative diseases. Our focus has been creating human stem-cell-derived models of these diseases that could help contribute to their understanding and treatment.

What do you think is the biggest challenge currently in your area of research?

The biggest challenge in DNA storage is still the cost of writing and reading DNA. Once that is solved, which I believe will be soon, the next challenge will be latency, or increasing the speed of information access that would open the technology to even greater application spaces beyond long-term archival information storage.

Have there been any particular career highlights in your career to date that you are especially proud of?

Honestly, I think I often feel something more like relief rather than a ‘highlight’ when grants are awarded or papers published, silly as that might sound, but I admit to feeling the practical pressures of running a research group or simply developing one’s own career prior to that. Instead, the ‘highlight’ feeling, the pride, the warm feeling of happiness has come when students I’ve mentored or am currently mentoring have a paper accepted, or when they earn poster or paper awards, teaching awards, or fellowships. When they get an interview for a dream job. Or when they get a really big experiment to work or figure out a really cool way to analyze complex data. Ironically, I also know that for them, often these ‘highlights’ also feel more like a relief.

Have you received any advice that you’ve found particularly helpful?

Yes. From both my ‘work-husband’ and actual wife: “Don’t worry about it.”

What would your advice be to someone just starting out in the field?

Seek out mentors who can guide you to read and push you to really deeply understand the core literature. Then, read broadly outside of the ‘synthetic biology’ field, as this is where many of the new application spaces and approaches can come from. Don’t worry too much about your first project’s specific area or topic, just tackle something deep and sophisticated to learn how to do research well; there will be time later to move into new areas through a postdoc or first job. Work hard, be as efficient as you can, but don’t take shortcuts or rush your way through your projects if you have the opportunity; it will be worth it in the long arc of one’s career to be patient and do the best science you can. Lastly, try to enjoy and celebrate achievements even though often by the time they occur, you’ll sometimes be feeling more relief than ‘highlight’.

Check Out Research from Dr. Keung and His Colleagues

Driving the Scalability of DNA-Based Information Storage Systems
ACS Synth. Biol. 2019, 8, 6, 1241-1248
DOI: 10.1021/acssynbio.9b00100

What Editors Need to Do to Fight Racism, Sexism, and Bias in Their Journals

Angewandte Chemie recently published a now-deleted article by Tomáš Hudlický that argued that diversity initiatives can only be a negative influence on the field of chemistry. I’ve had many conversations about this article with other researchers who have taken the time to thoughtfully detail the endless problems with his perspective. These conversations made me want to focus on what editors and reviewers for scientific journals should be doing to prevent this from happening in the first place.

Dr. Pamela Tadross

When I get a manuscript as an associate editor, I specifically look for bias, bigotry, and unfounded assumptions/opinions. I do all of this before sending the article out for peer review. If you’re an editor and you’re not doing that, then you’re part of the problem.

When I send out a manuscript for review, I select reviewers with diversity as a priority. These manuscripts only survive peer-review when you send a manuscript to a group of reviewers just like Hudlický for review. If you aren’t ensuring that your reviewers are diverse, then you’re part of the problem.

When I receive reviews, I screen them for bias and if a reviewer was not objective, I seek additional reviews. If I do share the biased review with the author, I add comments that they should disregard the problematic comment. If you don’t screen reviews, then you’re part of the problem.

If you find a reviewer provided biased feedback to authors, tell your editor-in-chief and other associate editors and block those reviewers from receiving future manuscripts for review. If you don’t proactively root this behavior out of our systems, then you’re part of the problem.

As a reviewer, read everything. Treat every word as a deliberate choice by the authors and if you have any issues, flag them and say why. Err on the side of caution. Tell the editor not to accept without appropriate revision. If you don’t speak up, then you’re part of the problem.

Don’t have time right now to review that new manuscript in your inbox? No problem! You have the ability to help editors diversify reviewer pools by recommending alternative candidates to review in your place.  If you’re not suggesting diverse new reviewers, then you’re part of the problem.

Is all of this a lot of extra work on top of our day jobs? Yes. Is it a critical responsibility as editors for scientific journals? Yes. If you aren’t willing to do the hard part of this job, then step aside and give someone else a chance. You’re part of the problem.

Dr. Pamela Tadross is an Associate Editor of Organic Process Research & Development.