December 2020 - ACS Axial | ACS Publications
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Meet the ACS Chemical Biology Early Career Board

ACS Chemical Biology is excited to announce its first Early Career Advisory Board appointments. This inaugural board features 25 young researchers with an impressive variety of expertise from across the globe. They will work with the journal’s Editor-in-Chief, Laura L. Kiessling, and its Associate Editors to share their experiences and perspectives on emerging topics within the chemical biology community.

Get to know the members of the ACS Chemical Biology Early Career Board.

Kerriann Backus, UCLA

What’s your background?

I received a B.S. in Chemistry and a B.A. in Latin American Studies in 2007 from Brown University. My doctoral research was conducted in the laboratories of Benjamin Davis (Oxford) and Clifton Barry (NIH, NIAID) as a 2007 Rhodes Scholar and an NIH Oxford Cambridge Scholar. My Ph.D. work focused on the development of chemical probes to label and image Mycobacterium tuberculosis. In 2012, I completed my doctorate and began an NIH postdoctoral fellowship at The Scripps Research Institute in the laboratory of Benjamin Cravatt. My postdoctoral research developed chemoproteomic methods for the proteome-wide identification of ligandable cysteine and lysine residues. At UCLA, my research has been recognized by numerous awards, including a Beckman Young Investigator, DARPA Young Faculty Award, a V Scholar Research Award, and a Packard Fellowship.

What are you currently working on?

The Backus lab integrates chemoproteomic methods with genomics and genetics tools to enable the rapid and proteome-wide identification of functional and potentially ‘druggable’ cysteine and lysine residues.

What do you hope to bring to the journal?

I hope to bring strong expertise in chemical probes and chemoproteomic methods to the journal. What I hope to see more of in ACS Chemical Biology is more technology development and interdisciplinary multi-omic methods.

What’s the most interesting challenge in your field at the moment?

Deciphering the functions of the thousands of ligandable residues across the proteome.

Jeremy Baskin, Cornell University

What is your background?

My training is in bioorthogonal chemistry, chemical glycobiology, and the cell biology of lipids and membranes. My Ph.D. work from Professor Carolyn Bertozzi’s lab at University of California at Berkeley focused on developing cyclooctyne reagents for bioorthogonal strain-promoted azide-alkyne cycloadditions and their application to in vivo imaging of glycans in developing zebrafish. My postdoctoral work from Professor Pietro De Camilli’s lab at the Yale School of Medicine centered on elucidating mechanisms controlling phosphoinositide synthesis at the plasma membrane and their role in the etiology of genetic diseases of the brain white matter.

What are you currently working on?

My lab at Cornell University operates at the interface of chemical biology and cell biology. We are fascinated by how cells produce specific lipids to control diverse signaling events. We are developing chemical tools to understand these phenomena, including new bioorthogonal metabolic probes and light-controlled, optogenetic enzymes, to visualize and perturb phospholipase D and phosphatidic acid signaling. We are also probing new mechanisms by which phosphoinositide lipids affect signaling in the cell by engaging and regulating lipid-binding proteins’ action. Our work has collectively shed light on how cells use these lipids to regulate pathways, including Wnt signaling and Hippo signaling in normal physiological and pathological contexts, including in cancer.

What do you hope to bring to the journal?

I am excited to bring to ACS Chemical Biology my perspectives from “both sides of the aisle,” as someone who is equally passionate about innovative chemical methods for observing important phenomena to generate new hypotheses and question-driven investigations to elucidate critical mechanisms in biological systems. I am committed to helping the journal broaden and diversify its reach, which encompasses both a diversification of scientific topics and promoting diversity in its key stakeholders — authors, reviewers, editors, readers — to best serve the community of chemical biologists.

What’s the most interesting challenge in your field at the moment?

In the world of lipid signaling, major challenges include developing tools to accurately track where specific lipids are produced in the cell and how they get shuttled from one membrane to the next. Equally important is sorting out the signal from the noise, that is, figuring out which lipids are the drivers of specific signaling events versus ones that are present but not the main actors in a particular physiological response. These challenges necessitate developing highly precise visualization tools and perturbation and physiologically relevant assays to probe biological mechanisms. I think they are perfectly emblematic of a 21st-century chemical biology problem: right at the interface of tools development and biological discovery.

George M. Burslem, University of Pennsylvania

What’s your background?

I completed my undergraduate degree in chemistry at the University of Bristol before moving to the University of Leeds for grad school. At Leeds, I worked in the labs of Professor Andrew Wilson and Professor Adam Nelson on inhibitors of protein-protein interactions. After graduating, I moved to the Department of Molecular, Cellular and Developmental Biology at Yale University to work with Professor Craig Crews as a Fellow of The Leukemia & Lymphoma Society working on targeted protein degradation. In 2020, I established my lab at the Perelman School of Medicine, University of Pennsylvania.

What are you currently working on?

My lab is interested in developing chemical tools to understand and modulate lysine post-translational modifications, specifically acetylation and ubiquitination. The laboratory is particularly interested in novel pharmacological approaches to modulate post-translational modifications that regulate gene expression and protein stability.

What do you hope to bring to the journal?

I hope to continue building a community of chemical biology researchers around the journal and highlighting early-career investigators’ work, including the graduate students and post-docs behind the papers. I would also love to highlight the power of chemical biology to our biological colleagues.

What’s the most interesting challenge in your field at the moment?

I think the most interesting challenge is always identifying new biological questions that can’t be answered using traditional approaches and then developing new chemical tools to answer them. For me, that might be orthogonal methods for targeted protein degradation or tools to break the ubiquitin code.

Chandrima Das, Saha Institute of Nuclear Physics, Kolkata

What’s your background

I completed my B.S. in Chemistry (Hons.) and M.S. in Biochemistry (Specialization: Molecular Biology) from University of Calcutta in 1996 and 1999, respectively. I obtained my Ph.D. from Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Bangalore, India, in 2007, with a specialization in chromatin structural regulation by Nonhistone Chromatin Associated Protein (NCAP). I performed my postdoctoral research at University of Colorado Denver (2008-2010) and M D Anderson Cancer Center (2010-2012) on the discovery and functional characterization of a novel human epigenetic mark, H3K56Ac. I was awarded Susan G. Komen Postdoctoral Fellowship for basic sciences in Breast Cancer Research (2009).

In summer 2012, I joined as a faculty member in Saha Institute of Nuclear Physics (SINP) and established the Chromatin Dynamics Laboratory. My focus has been on the modulation of chromatin structure by selective epigenetic recognition by a class of proteins entitled chromatin “reader/effector.” We are trying to understand these chromatin-binding transcription factors’ diverse functions to dictate the on/off state of the underlying genes in different physiological conditions and pathological states like cancer, metabolic, and infectious diseases. I have received prestigious Research Grants funded by Govt. of India, including Ramalingaswami fellowship from Department of Biotechnology (2011-12), Swarna Jayanti Fellowship from Department of Science and Technology (2017-18), and S. Ramachandran – National Bioscience Award for Career Development – 2019, from Department of Biotechnology, Govt. of India.

I have been elected as a member of the West Bengal Academy of Science and Technology (WAST). This society promotes basic and applied science and technology in West Bengal, India. I am also the Life Member of Indian Society of Cell Biology (ISCB), Indian Association for Cancer Research (IACR), Society of Biological Chemists (SBC), India, Chemical Biology Society (CBS), India, and a Member of The American Society for Biochemistry and Molecular Biology (ASBMB). Recently, I have been nominated as a member of The ACS Chemical Biology Early Career Board.

What are you currently working on?

We have started a vibrant research group in the Biophysics & Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, India. Our group focuses on understanding the fundamental mechanisms of epigenetic deregulation of genes in human diseases and has made several seminal contributions in the field. In this context, we are working on a specific class of proteins called chromatin “readers/effectors,” which are known to impact the epigenetic mechanisms in normal conditions as well as diseased states.

Our laboratory’s research work includes the role of epigenetic readers in tumorigenicity. Breast cancer is one of the major causes of mortality in females. The heterogeneity of the disease is a therapeutic challenge. Through early diagnosis, breast cancer has been challenged with conventional therapies, including chemotherapy, radiation therapy, hormonal therapy, and surgery. Complexities arise with a particular subtype of the disease, which is Triple-Negative Breast cancer (TNBC), as this particular subtype is the most aggressive and therapy non-responsive form of the disease, with potential chances of relapse. In this context, our laboratory is working on an important chromatin reader protein Zinc Finger MYND (Myeloid, Nervy, and DEAF-1)-type containing 8 (ZMYND8). ZMYND8 has been shown to harbor conventional CHD4-independent functions in regulating gene expression through its modified histone binding ability (J Biol. Chem., 2016).
Further, ZMYND8 has been shown to suppress tumorigenicity through independent molecular mechanisms: (i) Positive regulation of epithelial gene expression programs (Biochemical Journal, 2017), (ii) Negative regulation of tumor-promoting gene expression programs (Cell Death & Disease, 2020), and (iii) Induction of cellular differentiation programs (J. Biosciences, 2020). Interestingly, the role of ZMYND8 in modulating retinoid-based therapy (as an All trans-retinoic acid-responsive transcription factor) opens up new avenues to combat tumor growth through an epigenetic perspective (BBA Gene Regulatory Mechanisms, 2017). Apart from this classical chromatin reader protein, we are also investigating the newly acquired functions of chromatin reader family members.

In this regard, we have recently identified that Plant Homeo Domain (Ph.D.) finger protein Ubiquitin Protein Ligase E3 Component N-Recognin7 (UBR7) has enzymatic catalytic activity. We have established that UBR7 has a novel histone H2B monoubiquitin ligase that suppresses tumorigenesis and metastasis in TNBC through modulating Wnt/β-Catenin signaling pathway (Nat Commun. 2019). Interestingly, we have also identified a novel substrate of chromodomain family protein CBX4/Pc2, which has an important role in tumorigenicity. For the first time, we show that hTERT is SUMOylated by SUMO E3 ligase CBX4 and promotes breast cancer migration and invasion (Biochem J., 2020). Apart from the mainstream research interest from our laboratory, we are also involved in collaborative projects on therapeutically important small molecules as regulators of epigenetic modifications.

What do you hope to bring to the journal?

The scope of interdisciplinary research in the field of biological science is ever-growing. Being trained in chemistry, followed by Biochemistry in Bachelors and Masters respectively, has led to a better appreciation of several interface problems in biology.ACS Chemical Biology provides an opportunity to facilitate both the biologists and chemists to translate their discoveries for a wider audience. Ranging from in vitro methods to ex vivo cell biological questions and finally validating the proof of concepts in vivo in the organismal models are enthusiastically encouraged in this journal. Having an overall understanding of these systems would help me contribute towards welcoming new research in epigenetics and chromatin biology, which is a contemporary area of active research globally. Further, being an active member of the editorial board could bring special advanced focused issues into fruition.

What’s the most interesting challenge in your field at the moment?

Epigenetic modifications of chromatin fine-tune the underlying gene expression programs and are causally related to the organism’s normal homeostasis and the pathobiological state. The epigenetic modifications are operated through a class of proteins termed as “chromatin reader/effector,” which lead to differential recruitment of other regulatory factors (including writers and erasers) to specific sites leading to activation/repression of gene expression. The epigenetic code created by the writer, reader, and eraser is complex and highly dynamic. Interpreting this epigenomic landscape has always been a challenging field of research. With the advent of CRISPR-Cas9 advanced genome editing system, it is possible to program this complex landscape in a more targeted manner. The major challenge would be to introduce gene-specific epigenetic alterations to make the transcription programs amenable to molecular cues given to the systems. Once we can program these genes by engineering the epigenomic landscape, the basic understanding and restoration of the disease states’ molecular scenario would be possible in the future.

Laura Dassama, Stanford University

Coming Soon!

Yael David, Sloan Kettering

What’s your background?

I received my B.S. in Biology from SUNY Stony Brook as a Summa Cum Laude. I was awarded the Howard Hughes Medical Institute Fellowship to perform molecular neurobiology research with Professor Lonnie Wollmuth.

I subsequently moved to the Weizmann Institute of Science in Israel, where I performed my graduate work with Professor Ami Navon at the direct Ph.D. track. There, I was trained as a biochemist, applying my knowledge to study polyubiquitination mechanisms and regulation. Realizing the power of interdisciplinary research, I moved to the Chemistry Department at Princeton University, where I combined my experience in cell biology and biochemistry with Professor Tom Muir’s expertise in peptide chemistry to develop novel tools towards the mechanistic investigation of histone post-translational modifications, including their site-specific manipulation in live cells. This methodology opened the door to performing research with chemical precision at a biochemical resolution and in a physiological context.

In September 2016, I brought my powerful program to the Chemical Biology department at Memorial Sloan Kettering Cancer Center to focus on cancer research. My lab has performed highly innovative and interdisciplinary research driven by outstanding questions in the Epigenetics field in the past four years. We developed key chemical tools that were applied, among others, to identify a new class of histone modifications that directly links metabolism and cell fate. My efforts thus far were recognized nationally and internationally as the ACS “future of biochemistry,” “rising start in chemical protein synthesis,” the Pershing Square Sohn Cancer Alliance award, the Parker Institute for Cancer Immunotherapy Career Award, and the NIH/NIGMS outstanding young investigators award, MIRA, among others.

What are you currently working on?

My lab’s research efforts apply core chemical biology, biochemistry, and cell biology techniques to address fundamental questions in transcription’s epigenetic regulation. Epigenetic regulation relies on the dynamic modification of the two building blocks of chromatin: DNA and histone packaging proteins, to establish and maintain cell identity and fate. We develop and utilize chemical methods to track, manipulate, and synthesize site-specifically modified histones in vitro and in vivo and study the roles that these modifications play in disease states, with the ultimate goal of targeting them therapeutics.

What do you hope to bring to the journal?

As a trained biologist who transitioned to chemical biology later in my career and ran a lab at a biomedical institute, I hope to bring a young and fresh perspective that may appeal to people of different backgrounds. Together with an innovative and multidisciplinary perspective, I hope to bridge fields and expertise, as well as academia and industry.

What’s the most interesting challenge in your field at the moment?

The field of chemical biology has been in a growth phase over the last couple of decades, but these last five years have seen the field move into hyperdrive. This transition is fueled by the huge technological leap in high throughput methodologies, quantitative proteomics, and genetic editing that enable the precise identification of new targets, the development of new ways to modulate them, and the capacity to determine the effect of the manipulation. However, we believe that the major conceptual transformation in chemical biology is in the types of questions these technologies aim at, which are becoming more translational to enable drug discovery. Chemical biology is thus pioneering a new bridge between academia and industry. Importantly, chemical biologists are becoming more focused on asking impactful biological questions and more fearless in their pursuit of understanding complex cellular mechanisms.

Over the last few years, there has been a surge in academic labs spinning out startup companies based on chemical biology-based technologies such as Vividon using chemoproteomic discoveries from the Cravatt Lab, Palleon that exploits glycol-immunobiology from the Bertozzi Lab, or Arvinas using the PROTAC technology from the Crews lab just to name a few. Large pharma companies have been building chemical biology departments to impact their drug pipelines and enable discovery efforts. These days, it is very common to see research conferences packed 50/50 with academic and industry scientists chasing similar goals.

One great example is the popular Bioorganic GRC meeting that is typically co-chaired by an academic P.I. and industry scientist, and equal attendance from both often lead to fruitful collaborations. For this upward trend is to continue, the next five years will be critical to deepening the intimate interaction between industry and academia. Given the complexity of biology, strengthening collaborations between industry and academic labs will be key over the next five years to continue this upward trajectory. Education of chemical biology trainees is also going to be important to teach and enable students to ask impactful biological questions, employ appropriate research strategies, and know-how to effectively communicate and work well with the diverse scientific backgrounds in the chemical biology melting pot.

This can be done through exposure to industrial components inside academic hubs, such as the WCM/MSKCC/RU Tri-Institutional Therapeutic Discovery Institute (TDI), establishing incubator hubs for accelerating startup companies, or through collaborations with pharma/biotech companies. We believe that chemical biology can serve as a powerful bridge between academia and industry that facilitates the synergistic impact on our fundamental understanding of pathological events and our capacity to treat them.

Laura Edgington-Mitchell, University of Melbourne

What’s your background?

I grew up on a goat farm in rural Kentucky before completing my bachelor’s degree in biology and chemistry at Transylvania University. Excited by the prospect of using chemistry to study biology, I enrolled in a doctoral program in the laboratory of Prof Matthew Bogyo at Stanford University (2007-2012). During that time, I began to develop chemical probes to study proteolytic enzymes in cancer and inflammation. For my postdoctoral studies, I packed up my chemical toolkit and moved to Melbourne, Australia. I applied my probes to study proteases in breast cancer metastasis at La Trobe University and then in inflammatory bowel diseases at Monash University. In 2018, I established the Protease Pathophysiology Lab at the Bio21 Institute within The University of Melbourne.

What are you currently working on?

I continue to maintain an interest in all things involving proteases. I work with chemists to diversify the available tools to study cysteine and serine proteases by imaging, proteomics, and other biochemical methods. I am applying these tools to study proteases’ contribution to gastrointestinal diseases, host-pathogen responses, cancer metastasis, and pain mediated by protease-activated receptors. My lab’s overarching goal is to establish proteases as biomarkers and therapeutic targets that will aid in the diagnosis and treatment of these diseases.

What do you hope to bring to the journal?

I have experience working in academic labs in two different countries/continents and across two very different systems. I also collaborate widely internationally and have worked with industry. This unique perspective will hopefully be a valuable addition to the journal.

What’s the most interesting challenge in your field at the moment?

There are more than 500 proteases in the human proteome. We have effective probes and inhibitors for only a small subset of these enzymes. Achieving specificity has proven difficult due to proteases having overlapping substrate preferences or very broad reactivity. New proteomics techniques provide more information about protease specificity, and novel screening techniques afford greater chemical diversity access. As such, the number of proteases that we can effectively target with chemical tools is rising.

Stephan Hacker, Technical University of Munich

What’s your background?

I studied Life Science at the University of Konstanz, Germany. I performed my doctoral research in Professor Andreas Marx’s group, working on synthesizing and applying fluorogenic probes to study nucleotide-dependent enzymatic processes. Afterward, I moved to the group of Professor Benjamin Cravatt at The Scripps Research Institute, La Jolla, California, where I developed chemical proteomic technologies to study the target engagement of lysine-directed covalent inhibitors with residue-specific resolution in a proteome-wide setting.

Since 2017, I am a group leader at the Technical University of Munich, Germany, where my group designs and synthesizes novel covalent inhibitors and uses them in phenotypic screenings and chemical proteomic experiments to identify new druggable targets proteins for antibiotics. My research focuses on the interface of chemistry and biology and develops novel chemical tools to better understand biological systems.

What are you currently working on?

My group’s current focus is to identify new target proteins for antibiotics that can be exploited to overcome the current health crisis caused by infections with antibiotic-resistant bacteria. For this purpose, my group is developing novel covalent inhibitors that allow us to target a diverse set of proteinogenic amino acids to broaden the applicability of covalent inhibitors to the vast majority of proteins. Furthermore, my group develops chemical proteomic technologies to use these protein ligands to globally understand which binding pockets in bacterial proteins are most suitable for targeted with covalent inhibitors. In this way, we identify prime candidates for the development of antibiotics with entirely new modes-of-action.

What do you hope to bring to the journal?

By joining the Early Career Board of ACS Chemical Biology, I hope to bring the specific challenges and needs of young independent investigators during the publication process into the journal’s focus.

What’s the most interesting challenge in your field at the moment?

In antibiotic discovery, overcoming the development of bacterial resistance to all marketed antibiotics by finding compounds with new mechanisms-of-action is one of the key challenges for the future. Finding compounds that can accumulate in the most challenging Gram-negative bacteria is a very important point to address in this context. In covalent inhibitor development, I am convinced that one key challenge is to find covalently reactive groups that selectively target diverse amino acids to address the multitude of important protein binding pockets that do not have a suitable cysteine residue.

Doris Hoeglinger, University of Heidelberg

What’s your background?

I’ve started as a chemist and, for a while, thought about going towards material science. But, luckily, I went to a biological institute for my master thesis, and my fantastic advisor introduced a multitude of biological questions that can be answered by often creating neat and elegant chemical tools. I was hooked and decided to pursue this further with a Ph.D. in biology, where I got interested in lipids’ biology, a topic that still fascinates me today.

What are you currently working on?

Our group studies lipid transport between organelles with a particular focus on the lysosome. To this end, we’re creating functionalized lipid probes that can be released inside living cells with a flash of light. Following their paths through the cell, we’re hoping to understand the basic biology of lipid homeostasis and their relevance in diseases such as lysosomal storage disorders.

What do you hope to bring to the journal?

I appreciate the opportunity to bring the perspective of an early career researcher and personally am glad to serve on a board that is also committed to highlighting the importance of diversity at every academic career stage. Scientifically, while I always appreciate the development of new chemical tools, I’m particularly interested in how their application allows one to answer previously inaccessible biological questions and how this opens up exciting new avenues of research.

What’s the most interesting challenge in your field at the moment?

In lipid biology, I think the biggest enigma is still to understand why there are so many different lipids. The cell invests a great deal of energy to make, distribute, and control thousands of different species’ levels. What are their individual functions, and how are they integrated into signaling processes? Here, the challenges mostly lie in finding the right tools to manipulate and follow the lipids of interest in their native environment.

Luca Laraia, DTU (Kopenhagen)

What’s your background?

I carried out a M.S. at Imperial College London, U.K., specializing in synthetic organic chemistry before moving to the University of Cambridge to carry out a Ph.D. in chemical biology. Here I focused on small molecule modulators of mitosis and DNA repair.

Following this, I moved to the Max Planck Institute of molecular physiology in Dortmund, Germany, where I focused on identifying small molecule modulators of autophagy and their targets using phenotypic screening, synthetic chemistry, and chemical proteomics. This led to new probes targeting lipid kinases, mitochondrial respiratory complexes, lipid transfer proteins, and lysosomal targeted agents. During my time at the MPI I was also involved in developing the pseudo-natural product concept to design and synthesize natural-product derived and inspired compound collections.

What are you currently working on?

My group is focused on the chemical biology of sterol-mediated processes. In practice, this involves the synthesis and biological evaluation of sterol-inspired and derived small molecules. In this context, we are actively looking to identify selective inhibitors of cholesterol transport proteins and are leveraging the power of targeted protein degradation in the field of cholesterol biosynthesis, metabolism, and transport. Our lab is a multidisciplinary environment combining synthetic chemistry, phenotypic screening, and cell biology, as well as chemical proteomics.

What do you hope to bring to the journal?

As one of the non-U.S. based researchers on the ECB, I hope to bring outside perspective to an ACS journal to widen the breadth of dialogue and ideas. I also hope to bring a synthetic and medicinal chemist’s view on a range of topics!

What’s the most interesting challenge in your field at the moment?

Cholesterol transport proteins are already reported to play roles in many processes, including, but not limited to, mediating organelle contact sites, autophagy, and viral entry. Developing selective tools to decouple their cholesterol transport function from other roles will help unravel their complex biology and provide potential therapeutics against a range of conditions.

Lingyin Li, Stanford University

Coming Soon!

Samira Musah, Duke University

Coming Soon!

Jia Niu, Boston College

What’s your background?

I received my B.S. and M.S. from Tsinghua University in China before moving to the U.S. to pursue a Ph.D. degree at Harvard University, working with Professor David Liu. After the doctoral study, I worked as a postdoctoral scholar with Professor Craig Hawker and Professor Tom Soh at U.C. Santa Barbara, before starting an independent faculty position at Boston College in 2017.

What are you currently working on?

My group focuses on three main thrusts: sustainable plastics, sulfated glycomimetics, and genomic editing. In the first direction, we are developing new strategies based on energetically favored cascade reactions to drive the polymerization or depolymerization of difficult synthetic and bio-derived monomers. In the second direction, we are developing new small molecule and macromolecular probes with defined sulfation patterns to study how sulfation as a chemical code function in signaling transduction. In the third direction, we are developing CRISPR genomic editors for programmable editing of genes and associated proteins through rational design and directed evolution approaches.

What do you hope to bring to the journal?

I hope to bring to the journal the perspective of a synthetic polymer chemist who is also interested in chemical biology and who sees synthetic polymers and biopolymers as unified “macromolecules” which functions range across biology and materials science.

What’s the most interesting challenge in your field at the moment?

There are three big questions I am most fascinated by:

  1. Can sustainable plastics be made out of renewable resources from biology and be 100% recycled?
  2. Beyond nucleic acid and protein, are there other molecularly patterned biomacromolecules that encode critical biological information? If there are, how is the information being written, edited, and read?
  3. For the biomacromolecules in (2), how can we develop synthetic systems to write, edit, and read the information to influence biology?

Sungwhan F. Oh, Brigham and Women's Hospital and Harvard Medical School

What’s your background?

I work in analytical chemistry and metabolomics.

What are you currently working on?

Bioactive metabolites originated from symbiotic microbiota and their host modulatory functions.

What do you hope to bring to the journal?

Experience in multifaceted natures of the field (on the interface of chemistry and biology).

What’s the most interesting challenge in your field at the moment?

Novel structure-function, biosynthesis, host-microbiota co-metabolism.

Emily Que, University of Texas, Austin

Coming Soon!

Vishal Rai, IISER Bhopal

What’s your background?

Chemical biology, bioconjugate chemistry, and organic chemistry.

What are you currently working on?

Chemical technologies for precision engineering of native proteins, antibody-drug conjugates, precision therapeutics.

What do you hope to bring to the journal?

The journal wants to bring the chemical biology community together and help in the field’s sustainable growth. I hope to join the team members and contribute positively to this mission.

What’s the most interesting challenge in your field at the moment?

How can we precisely engineer or target proteins? This question’s answer can address the technological demands of biotechnology, protein-based therapeutics, and precision therapeutics with covalent inhibitors.

Pablo Rivera-Fuentes, EPFL

What’s your background?

I got a Ph.D. in organic chemistry at ETH Zürich. I did a oost-doc in bioinorganic chemistry at the Massachusetts Institute of Technology and a short post-doc in bioorganic chemistry and biophysics at Oxford University.

What are you currently working on?

The development of organelle-targeted redox-active probes, small-molecule fluorophores for super-resolution microscopy, activity-based probes, and fundamental photophysical studies of single molecules.

What do you hope to bring to the journal?

Some expertise in using organic chemistry to develop tools to study cell function and image single-molecules in live cells. Also, some interesting perspectives from a career path that has taken me through several different countries and cultures.

What’s the most interesting challenge in your field at the moment?

Developing multiplexed labeling and imaging methods would allow us to observe multiple different biomolecules with single-molecule resolution. The first step towards spatially-resolved, single-molecule omics!

Sara Sattin, Università degli Studi di Milano

What’s your background?

I studied industrial chemistry and management and then undertook my Ph.D. studies in chemical sciences at the University of Milan, working on glycomimetic antiviral compounds in the framework of anti-adhesive therapies. After some postdoctoral fellowships on supramolecular chemistry (ICIQ, Tarragona, Spain) and chemical biology (University of Oxford, U.K.), in recent years, I have been working on the allosteric modulation of Hsp90, a chaperone protein. I started my research group at the University of Milan in 2017, thanks to an ERC Starting Grant award on eradicating chronic infections.

What are you currently working on?

The focus of the group at the moment is the design and synthesis of small molecular inhibitors of a bacterial protein involved in bacterial persisters formation, a phenotype tolerant to antibiotic treatment that favors the onset of antimicrobial resistance. We are also interested in glycomimetics targeting relevant human and bacterial lectins (i.e., proteins that recognize carbohydrates).

What do you hope to bring to the journal?

I would like to bring the perspective of someone that developed a multifaceted view of the synergic interplay between organic chemistry and chemical biology. I don’t like to put science in tidy labeled boxes, and I think we should try to fully embrace the complexity of the topic we are investigating rather than focusing exclusively on a small part of the picture.

What’s the most interesting challenge in your field at the moment?

There are several interesting challenges to take on in the field, but I think that the most urgent (and interesting) is to give a rapid response to the prevalence of antimicrobial resistance, including the serotype shift observed for some strains after vaccination campaigns. Now, more than ever, this can be achieved effectively only by a strong interplay between chemistry and biology.

Neel Shah, Columbia University

What’s your background?

I received my B.S. in chemistry from New York University. There, I worked with Professor Kent Kirshenbaum on the synthesis and structural characterization of peptidomimetic oligomers. I did my Ph.D. in Professor Tom Muir’s lab, partly at The Rockefeller University and partly at Princeton University. My Ph.D. research involved discovering and characterizing new “ultrafast” split inteins and their application to protein synthesis and engineering. My postdoctoral research was carried out at University of California at Berkeley, in Professor John Kuriyan’s lab. There, I developed new high-throughput methods to examine specificity and allostery in eukaryotic signaling proteins by coupling functional selection assays to deep sequencing of variant libraries.

What are you currently working on?

My lab focuses on phosphotyrosine signaling proteins and pathways. We are developing chemical probes, high-throughput biochemical assays, and cell-based methods to probe allosteric regulation and substrate/ligand specificity in protein tyrosine kinases and protein tyrosine phosphatases. We are particularly interested in phosphotyrosine signaling enzymes that are mutated in human cancers and those that play a direct role in T cell activation.

What do you hope to bring to the journal?

I’m excited to be a part of the Early Career Advisory Board, in large part because I want to push for more opportunities for early-career researchers (not just young principal inversitgators, but trainees also) to showcase their work and get their names out. I’m excited to take on initiatives to have young guest editors, highlight first authors on papers, and maybe even have entire issues with papers/reviews/editorials by early-career researchers!

What’s the most interesting challenge in your field at the moment?

I think the most intriguing challenge in my field is to discover drug allosteric sites in proteins. The signaling enzyme families we study are highly degenerate in their active site structures, making selective inhibition a challenge. Furthermore, given that the proteins we study are cancer-associated, therapeutics that target these enzymes almost always succumb to drug resistance. A major breakthrough in our field would be to develop a systematic way to map “druggable” allosteric sites in proteins and discover potent allosteric inhibitors that bind at that site. A particularly exciting extension of this challenge is the development of allosteric activators of key regulatory signaling enzymes.

Darci Trader, Purdue University

Coming Soon!

Marthe Walvoort, University of Groningen

What’s your background?

I received my Ph.D. in carbohydrate chemistry at the Leiden University under Professor Jeroen Codée, Professor Gijs van der Marel and Professor Hermen Overkleeft. My research included investigating the mechanism of glycosylation of mannuronic acids, and I performed the automated synthesis of β-mannuronic acid alginates and hyaluronan using a solid-phase oligosaccharide synthesizer. Next, I moved to Professor Barbara Imperiali’s lab at Massachusetts Institute of Technology, where I developed inhibitors of phosphoglycosyltransferases inspired by nucleoside antibiotics. Moreover, I established a link between bacterial infection and biomarkers in multiple sclerosis by producing N-linked glycoproteins.

What are you currently working on?

In my independent research group at the Stratingh Institute for Chemistry at the University of Groningen, we combine the power of carbohydrate chemistry and glycobiology to investigate glycans in health and disease. We focus on ‘healthy sugars’ inspired by human milk oligosaccharides and investigate the impact of newly synthesized carbohydrate structures on specific health effects in infants and health-compromised adults.

As bacterial glycoproteins are often involved in pathogenicity, we aim to unravel the mechanisms of bacterial protein glycosylation machinery, focusing on protein glycosyltransferases such as Asn-glucosyltransferase HMW1C (from H. influenza) and Arg-rhamnosyltransferase EarP (from P. aeruginosa). By fully understanding their mechanistic details, we aim to exploit these enzymes as targets for novel antimicrobial design.

What do you hope to bring to the journal?

I am excited to be part of this group of diverse early-career scientists and expect that we will inspire each other to develop new initiatives that will benefit other early-career scientists and the chemical biology society at large. I aim to make ACS Chemical Biology both an attractive platform to show the best chemical biology research, and at the same time, highlight the (team) effort, enthusiasm, and personal stories behind the science through online content.

What’s the most interesting challenge in your field at the moment?

With the increasing amount of knowledge on oligosaccharides’ health effects in developing infants, I look forward to seeing this evolve into novel (medical) food additives, especially for premature and health-compromised infants. The most promising glycan structures will have to be identified and produced on a large scale to achieve this goal. Along the same lines, I think it will be very exciting to see a functional inhibitor of bacterial glycan/glycoprotein synthesis reach the stage where it can be evaluated for antibacterial activity in vivo.

Xiao Wang, Broad Institute

Coming Soon!

Amy Weeks, UW-Madison

What’s your background?

I got my undergraduate degree in chemistry at Massachusetts Institute of Technology, where I performed thesis research investigating the ClpAP proteolytic molecular machine with Dr. Stuart Licht. I went on to earn my Ph.D. at the University of California at Berkeley, in the Department of Chemistry and the Chemical Biology Graduate Program.

As an NSF Graduate Research Fellow in Dr. Michelle Chang’s lab, my research focused on understanding the chemical mechanisms that underpin biological function in Streptomyces cattleya, a soil bacterium that has evolved the unusual ability to biosynthesize organofluorine natural products. After completing my Ph.D., I explored how enzymes can be re-engineered as tools for chemical biology. My research as a Helen Hay Whitney Postdoctoral Fellow in Dr. Jim Wells’s lab at UCSF focused on re-engineering the specificity of the designed peptide ligase subtiligase to enable unbiased capture of free N termini for global sequencing of proteolytic cleavage sites using mass spectrometry-based proteomics. We further developed this technology to capture proteolytic neo-N termini on the surface of live cells, opening up opportunities for mapping proteolysis with subcellular resolution.

What are you currently working on?

My research group develops and applies tools for spatially and temporally resolved mapping of post-translational modifications (PTMs) in living cells. PTMs control the structure, activity, localization, and lifetime of nearly all proteins and are often dysregulated in human disease. However, identifying PTMs has far outpaced assignment of their biological functions, a challenging endeavor that requires detailed information about where and when these modifications occur within the cell. My lab integrates principles from organic chemistry, protein engineering, and mass spectrometry-based proteomics to develop and apply enzymatic tools for spatially and temporally resolved mapping of protein modifications in living cells. These technologies will advance our understanding of how post-translational modifications program biological function, leading to the development of new therapeutic hypotheses to treat human disease.

What do you hope to bring to the journal?

I’m really excited to join the ACS Chemical Biology Early Career Board! I’m hoping to bring an early-career perspective on the most exciting challenges in our field, strengthen connections between emerging researchers in biology and chemistry, and support early career researchers in the chemical biology community.

What’s the most interesting challenge in your field at the moment?

Over the past two decades, chemical tools have enabled us to catalog PTMs to proteins—to ask the ‘who’ (which proteins) and ‘what’ (which PTMs) questions about biological signaling. However, to move beyond simply cataloging these modifications, we need new technologies that will enable us to ask, on a proteome-wide scale, why specific modifications were installed and how they execute their functions on a molecular level. A really exciting challenge is to develop tools that will enable PTM mapping in living cells with spatial and temporal resolution. These tools could provide insights into which modifications have meaningful phenotypic consequences and would allow us to develop a molecular-level understanding of what those consequences are. This information would allow us to functionally prioritize PTMs for follow-up experiments and to dissect previously unappreciated functional nodes in biological signaling pathways. Given the central importance of PTMs in human biology, insights into their spatiotemporal dynamics will advance fundamental biological knowledge and are likely to lead to the identification of new therapeutic targets and biomarkers in human disease.

Kaelyn Wilke, MilleporeSigma

What’s your background?

I’m a Wisconsin native from Green Bay, WI. I received my B.S. in biochemistry from the University of St. Thomas in St. Paul, MN, before starting my chemical biology graduate career in the lab of Professor Erin Carlson at Indiana University in Bloomington, IN. In my doctorate work, I used chemical probes to develop new ways to screen, evaluate, and deactivate histidine kinases, proteins implicated in various bacterial signaling pathways, and promising targets for novel antibacterials. Upon completing my Ph.D., I joined the Chemical Synthesis product management team at MilliporeSigma (formerly Sigma-Aldrich) in Milwaukee, WI. I am currently a Senior Product Manager, leading our chemical biology product roadmap that identifies and commercializes reagents and tools critical to emerging areas of chem-bio and early drug discovery research.

What are you currently working on?

I am currently working on a portfolio that supports research for “undruggables.” While the term “undruggable” can take on slightly different meanings, it generally refers to the 80% of the proteome that has been difficult to target and treat through traditional small-molecule drug discovery. One primary reason is they lack the deep, defined pockets required for inhibitors to bind with high affinity and deactivate them (examples are scaffolding proteins or transcription factors, among others). There is an exciting abundance of global research in this space across academic, pharma, and biotech labs! In my role, I look for ways to translate new developments to the greater drug discovery community by making them accessible to any researcher. For undruggables, I have focused on tools that accelerate lead discovery, target engagement, and targeted protein degradation. This requires an intimate following of the chemical biology space, but it is really just the first step. After a new product (or product area) is identified, I work with a large team to develop and introduce it to the research market.

What do you hope to bring to the journal?

Going from in-lab research to perhaps a less-traditional career route for a Ph.D. chemical biologist, I’ve been challenged to think more broadly about chem-bio research at the interface of academia, pharma, and startups and within the context of an increasingly digitally communicative environment. I hope that I can bring an alternative view to the chem-bio landscape, foster creative ways to make connections between emerging researchers and its readers, and promote the interdisciplinary approaches within chemical biology to address challenging problems in life science.

What’s the most interesting challenge in your field at the moment?

One of the most interesting challenges in looking at the undruggables space is harmonizing data and techniques. As is common in research, one idea seeds many more. If we take protein degraders as an example, these bifunctional and chimeric molecules were developed to eliminate cells’ protein targets by hijacking the cell’s proteasomal system. We’ve observed that since their broader adoption is the development of other bifunctional molecules capable of exploiting several other cellular processes, such as post-translational modifications. How might this growing set of chimeric tools be used holistically? What validation and tools are needed to ensure reproducibility to extract data useful to one researcher’s biological system and be suitable for comparative -omics, computational platforms, and algorithms?

Christina Woo, Harvard University

What’s your background?

I did my graduate training in total synthesis and mechanism of action studies, followed by a postdoctoral fellowship in chemical biology, where I developed a chemical glycoproteomics platform.

What are you currently working on?

We combine the rational design of small molecules and proteins with chemical proteomics to manipulate cellular signals and target “undruggable” proteins.

What do you hope to bring to the journal?

New ideas and new directions!

What’s the most interesting challenge in your field at the moment?

How to determine the function of a small molecule or post-translational modification within a cellular context.

Get Ready for 2021 With These Free Chemistry Zoom Backgrounds

Video calls will continue to be an essential part of our working lives in 2021. Why not give your Zoom calls a little extra flair with these beautiful, free, chemistry-themed backgrounds, courtesy of ACS Publications? Each colorful background features a distinctive look, representing one of the nine new ACS Au journals launching in 2021. Fill out this form and download your favorites today.

Get Your Free Zoom Backgrounds

Discussing Work-Life Balance in the Lab

Work-life balance has been a concern for researchers for many years. Chemistry is a demanding field and it takes special effort for researchers to maintain a healthy equilibrium. But this challenge can look very different, depending on where one works and what stage of their career they are at, which is why ACS Publications recently hosted the webinar on work-life balance in the lab, as part of their ongoing Changing the Culture of Chemistry series.

This one-hour program featured a panel of engaging speakers, including:

  • Devin Swiner, Ph.D. Candidate, expected 2021, Ohio State University, who spoke about maintaining balance as a student. She shared her tips for spotting potential burnout and strategies for carving out time for yourself.
  • Dr. Dan Hickman, DOW, spoke about his personal experiences as a chemical engineer working in industry, discussed the philosophical underpinings of a balanced life, and shared his advice for attaining balance in your career.
  • Professor Lynne S. Taylor, Retter Professor of Pharmacy, Purdue University College of Pharmacy, discussed her approach to leading a lab that values work-life balance and shared her advice for creating an organizational culture that values balance.

Dr. Laura Fernandez of ACS Publications acted as the program’s moderator, fielding questions from attendees at the end of the event.

Watch the full presentation of Changing the Culture of Chemistry: Work-Life Balance in the Lab:

Introducing a Better Copyright and Permissions Experience from ACS Publications

ACS Publications is pleased to announce the launch of an improved copyright and permissions experience across our journal portfolio.

We are expanding our range of Journal Publishing Agreements to make copyright options clearer and help our authors meet funder requirements, focusing on those agreements attached to open access articles. The change, applicable to all articles in pure open access journals and all open access papers published in hybrid journals, will adopt the Creative Commons license. CC-BY-NC-ND is the default license, and CC-BY is provided as an option. Hence, these agreements will not require copyright transfer to ACS.

From a process standpoint, you will no longer need to submit a completed Journal Publishing Agreement at the submission stage; we will only ask for this once your manuscript has been accepted to an ACS journal. Upon acceptance, you will receive an email with a customized link to complete and sign a Journal Publishing Agreement; from here, we will guide you through the process with a series of questions to help determine the most appropriate agreement for your manuscript.

This new process makes your publishing experience with ACS that much easier by:

  • Simplifying the Journal Publishing Agreements, easing author decision-making, and streamlining workflows around submission and acceptance;
  • Enabling ACS to continue to offer a range of services and protections to authors who choose to publish articles at no charge under a subscription-access model;
  • Conforming with emergent open access community standards and funder requirements regarding copyright ownership and licensing for open access articles.

These new changes are scheduled to launch in early January of 2021. Find out more about the new Journal Publishing Agreement on our dedicated landing page, and refer to the flowchart above to understand the best option for your article.

The Impact of the COVID-19 Pandemic on Early Career Researchers

Nano Letters Early Career Board Member Nicolò Maccaferri

The COVID-19 pandemic emergency has affected many young researchers’ lives at the early stage of their careers, impacting an already quite fragile personal life/work balance. Nevertheless, we think that we have learned a lot from this situation in the past months. We genuinely believe that what we are going through will make us stronger in facing future challenges. In this post, we would like to share our experiences and opinions on what is happening to us as human beings and scientists, hoping that our experience will help others see the glass as half-full and not lose hope.

During the first lockdown, we tried not to fear what could happen to us in the future and instead focus on the present. Adapting to the “new normal” with peace of mind meant concentrating our efforts on what we could do at that precise moment rather than on what we couldn’t. This mind-set helped us realize the important things in our daily work and, most importantly, in our lives. Even if we faced a drop in our productivity, we could create new routines and set new boundaries between our work and private life, enjoying more time spent with our partners and kids.

Nano Letters Early Career Board Member Po-Chun

We also had more moments of self-examination, realizing that, despite the terrible events, we were not losing our motivation. If we kept doing our activities to the best of our ability, that motivation would not drop at all.

Of course, we all felt frustrated that social distancing was hurting many opportunities for collaboration and shared equipment access. For experimentalist groups, locking down slowed down our progress, but we were, nevertheless, able to focus on computer-based work, which gave us a bit of breathing room. We could spend time developing computational skills, focusing on literature research, analyzing data, writing articles and theses, putting together reviews, and planning future activities and experiments with more imagination than before because all of us had more time to think about new ideas.

Nano Letters Early Career Board Member Nikolay Kornienk

Some of us also started to organize online conferences and workshops. This positive attitude fostered many new ideas and collaborations since we could share our latest findings with our colleagues without moving from our homes or offices.

Moreover, the possibility to share more quality time with our families was one of the best outcomes of this situation, since we all realized how beautiful life is (and short it might be). Spending more time with them allowed us to understand how important the awareness (and the power) of loving and to experience a life worth living.

We also think that this pandemic, although not automatically providing the general public with an immediate awareness of the importance of science, will undoubtedly increase this awareness in the long term. Hopefully, soon politicians and society as a whole will listen more to scientists about potential threats, not just about epidemics but also on other issues like climate change. We also feel that a lot of research fields might change and evolve. Many researchers with different backgrounds working on various topics have jumped into studying COVID-19 and how to fight it from other points of view.

Nano Letters Early Career Board Member Fiona Li

This threat has also united many scientists in realizing that we can address these types of challenges only if we build a scientific community that is in service of all of humanity. We also think that we have to continue doing fundamental science since there is plenty of significant fundamental research without imminent applications. Fundamental research is meaningful not just for short-term goals but also for long-term goals that could benefit society.

At the time we are writing this post, we are facing a second lockdown, at least in many western countries, but we believe we are capable of meeting these next waves with more determination.

In this Q&A, Nano Letters Early Career Board Members Nicolò Maccaferri and Sophie Meuret interviews their fellow members Po-Chun Hsu, Nikolay Kornienk, and Fiona Li.

Nano Letters Early Career Board Member Sophie Meuret

How did you face the lockdown period?

  • Po-Chun: Try to be a “glass-half-full” person and adapt to the new normal.
  • Nikolay: Agreed fully. I focused on what I could do rather than what I could not and take advantage of wherever I can.
  • Fiona: Face it with peace of mind and try to adapt to the situation.

Are you still in a lockdown situation? In either case, how are you organizing your group activities? As usual or with restrictions?

  • Po-Chun: Duke has reopened (partially) since early June, but the style is very different because of the social distancing.
  • Nikolay: No lockdown in Montreal, but we are operating at partial capacity and taking all possible precautions (masks, social distancing, online meetings, etc.)
  • Fiona: Dartmouth reopened partially. My group members are doing shifts so that most of the time, only one person is in the lab per shift (with masks and social distance).

Is it hard to continue doing your daily job when you are not as free to move as before?

  • Po-Chun: For me (and many early-career researchers), the challenge mainly comes from the juggling of work and parenting.
  • Nikolay: Certainly, adapting to less available time and additional responsibilities was a challenge. I have had to temper my expectations of what I could accomplish.
  • Fiona: It is very hard to work as efficiently as before, especially need to balance between parenting and work. This is especially hard for early-career women faculties with kids. I recently read an article published in Nature Human Behavior, talking about this issue.

Did you share more quality time with your family during the lockdown?

  • Po-Chun: Yes!
  • Nikolay: Of course, that was really a positive aspect of this whole situation. On the other hand, extended family members from abroad could not visit so we do our best to stay in touch virtually
  • Fiona: Absolutely!

Do you think the scientific world will change after this situation? Will there be more awareness of science’s importance? Do you think people will look at us with different eyes? Do you believe that we will have to re-formulate our priorities as researchers?

  • Po-Chun: I think this pandemic itself may not automatically provide the general public with more awareness of science’s importance. But should certainly use this opportunity to engage social media and to make a broader impact.
  • Nikolay: I think awareness will certainly increase, and hopefully, politicians and the general public alike would listen to scientists about potential threats – not just about epidemics but also on issues like climate change
  • Fiona: I feel a lot of related fields in science might change. Many researchers have jumped into studying COVID-19, and many of them will want to continue.

Do you feel that what you are doing as a scientist is still very important and should be pursued even in these uncertain times? Or would it be better to stop doing what we are doing and refocus our research efforts to fight this type of threat directly?

  • Po-Chun: There were indeed a few moments of self-examination. Still, I believe there is much fundamental research that is important even without imminent applications.
  • Nikolay: I believe so – science is carried out with a greater purpose in mind, whether the results have near-term or long-term implications.
  • Fiona: Yes, I believe so. I believe what we are doing is meaningful not just for short-term goals but also for long-term goals that could benefit society.

Did a lockdown have a significant impact on your research timeline?

  • Po-Chun: Yes. What makes it particularly difficult for young investigators is that social distancing hurts many opportunities for collaboration and shared equipment access.
  • Nikolay: Surely, it did. We shifted our focus for some time on computer-based work and are slowly getting back into experimental work.
  • Fiona: Yes. Since the research in my group is experiment-based, locking down definitely slows down our progress.

If you had to manage students, how did you keep them motivated and consider the difficult personal situation they might be facing?

  • Po-Chun: I tried to keep them busy and productive by spending time on computational skills and literature research. Both of which will come in handy in the future.
  • Nikolay: Same – we focused on thesis writing, putting together reviews, and so on. It wasn’t the same, but we make the most of what we can do.
  • Fiona: Same here. I tried to keep them busy by writing review articles, reading literature, and summarizing their data.

Did you feel a lack of motivation or productivity due to the lockdown? If yes, how did you fight it?

  • Po-Chun: The productivity did drop. I found it useful to create a new routine and set a new boundary between work and life.
  • Nikolay: Yes, it’s hard to keep momentum amidst a changing schedule but I tried to keep a to-do list for each day and stick to it
  • Fiona: The productivity certainly drops, but not the motivation I believe. I am still in the middle of seeking an efficient way to balance work and parenting.

Are you going to change some of your work habits (research and management) after the end of the pandemic?

  • Po-Chun: During this pandemic, I recruited quite a few remote interns, which could be a new way to do research.
  • Nikolay: I believe so. More regular formal meetings (even if done remotely) has been a plus for us. With the rest, I guess we will see as we return to a more normal environment
  • Fiona: yep. The pandemic makes us realize how much work can be done remotely. I think some of the habits will be kept even after the pandemic is over.

Learn More About the Nano Letters Early Career Board

Congratulations to the 2021 Recipients of the ACS Sustainable Chemistry & Engineering Lectureship Awards!

The Editors of ACS Sustainable Chemistry & Engineering and the ACS Green Chemistry Institute are pleased to announce the three award winners of the 2021 ACS Sustainable Chemistry & Engineering Lectureship Awards. These awards recognize the research contributions of scientists in three geographical regions, working in green chemistry, green engineering, and sustainability in the chemical enterprise. The winners must have started their initial academic appointment within the past 10 years or have received their terminal degree/completed their last professional training within the last 10 years.  Congratulations to the 2021 award recipients representing the three regions: The Americas, Europe/Middle East/Africa, and Asia/Pacific.

Watch a Video Interview with the Recipients

Read my interviews with the 2021 Recipients of the ACS Sustainable Chemistry & Engineering Lectureship Awards:

Jun Huang, The University of Sydney

How is your research specifically important to your region of the world versus on a global scale?

Sustainable development is a significant challenge for the Asia/Pacific region since its population is over 4.3 billion, 60% of the world’s population, with increasing demand for energy and chemicals as well as increasing waste and CO2 emissions in the region. My research is to address the fundamental issues for sustainability in the region and is focused on the development of novel catalysts and catalytic technologies to minimize CO2 emissions for oil-refining, to advance biorefining for renewable resources, and to convert CO2 and solid wastes to high-value fuels and chemicals. My research outcome enhances the economics of sustainable technologies and will promote the commercialization of them in most developing countries in the region.

What would you like government and/or industry representatives to understand about your research?

My research is a significant step forward in solving the current major technical and economic challenges faced in sustainable development. Our outcomes can be moved out of the laboratory and into industry.

Tell us about a research collaboration your group has undertaken.

My group is active in international collaboration. I successfully led the catalysis sub-team in the EU Horizon 2020 Marie Skłodowska-Curie Actions, Research, and Innovation Staff Exchange (H2020-MSCA-RISE 2015-2018) ‘Development of flexible pyrolysis-catalysis processing of waste plastics for the selective production of high-value products through research and innovation, €634.5k’. This great success has facilitated the team to continuously be awarded another EU Horizon 2020 project in 2019-2022 ‘Biomass gasification with negative carbon emission through innovative CO2 capture and utilization and integration with energy storage, EU€832k’. My group is also an active member of the Global Network of Green Materials with CNRS, NIMS, National Taiwan University, Waseda University, National Singapore University, and Hokkaido University.

We have a long-term collaboration with ETH Zurich, Universities of Leeds, Stuttgart, Bremen, Tufts, and Lille. Supported by the University of Sydney’s Collaboration Award grants, we built up new collaborations with UC Davis, SLAC Stanford, Ames Lab, Brookhaven National Lab, National Taiwan University, Tsinghua University, and Zhejiang University.

Within the University of Sydney, I have initiated and been successfully leading the Sydney Nano Grand Challenge of “Nanotechnology for Carbon-Neutral Manufacturing” for CO2 conversion and H2 production that brings together 15 experts cross 6 schools in nanocatalysis, process engineering, artificial intelligence and machine learning, quantum physics, and chemistry, molecular science, and computation, as well as characterization on an integrated platform for advanced carbon-neutral manufacturing.

What type of work can we look forward to seeing from you in the future?

My group has developed a combined in situ characterization platform of spectroscopy and microscopy. The capability to ‘see inside both the reaction and catalyst’ provides quantitative and qualitative results necessary to significantly improve the catalyst design and optimize the reaction process. Based on the in situ platform, we will develop multi-functional catalysts for CO2 conversion and biorefining to high-value fuels and chemicals using low-cost catalysts and simple operational processes.

Jeremy Luterbacher, École Polytechnique Fédérale de Lausanne

How is your research specifically important to your region of the world versus on a global scale?

Sustainability is a global problem and chemistry research applied to sustainability is similarly global. Our ultimate hope is that it will lead to the adoption of new industrial products or processes that reduce environmental impacts. Where that happens is not important. Since Europe is probably the continent that, politically, is taking climate change and environmental issues most seriously, implementation of our work might receive more early-implementation support on this continent; but at the rate things are changing, that’s not a given.

What would you like government and/or industry representatives to understand about your research?

A lot of our work has been about building chemistry that fits the plant’s chemical structure. This leads to much more efficient, sustainable, and seemingly cost-effective solutions than trying to retrofit plant chemistry to petroleum chemistry. However, industry often wants the exact molecules they already use, but just made from renewable sources. I think it would be more forward-thinking to rethink their conversion chains based on what is actually available in nature.

Tell us about a research collaboration your group has undertaken.

We have begun to scale up some of the production of the acetal-based processes and molecules, the development of which was recognized by this prize. This has allowed us to begin collaborations with several industrial partners in the fragrance, flavor, and food packaging sector who are testing these products and hopefully guiding us towards commercialization.

What type of work can we look forward to seeing from you in the future?

We plan to continue to develop processes and products that are centered around plant chemical structures. In other words, we want to redesign chemical conversion routes to take full advantage of what nature provides. This will often lead to different molecules and materials than those available today, but which are hopefully more sustainable to produce, and perhaps even safer to use and dispose of.

Meagan Mauter, Stanford University

How is your research specifically important to your region of the world versus on a global scale?

The mission of the Water & Energy Efficiency for the Environment Lab (WE3Lab) is to advance the energy efficiency of desalination. We pursue this mission by bridging novel unit process development with equation-oriented process optimization and computational systems analysis to identify and develop high impact innovations for decarbonizing water supply. This work is important both for securing global water supplies and for ensuring that supplying water does not negatively impact our global climate. Some of our most recent research on the synergistic operation of water and electricity grids will find special relevance here in California, where innovative electricity market structures provide unique incentives for water utilities to sell energy flexibility services to the grid.

What would you like government and/or industry representatives to understand about your research?

Government and industry tend to address the twin crises of water scarcity and degraded water quality with large-scale infrastructure investments— picture a 50 million-gallons-per-day coastal desalination facility. While these historic investments will continue to provide a large fraction of our water supply, our research suggests that small-scale, decentralized water reuse systems may provide a more cost-effective solution to augmenting our future water supply. Realizing this future will require R&D investments in autonomous, precise, resilient, process intensified, modular, and electrically powered technologies that support locally tailored treatment of nontraditional waters at a cost comparable to other sources. Realizing this future will also require policy levers for incentivizing decentralized water reuse. Unlike traditional grants made to water utilities to subsidize large capital projects, distributed water system deployment may require targeted tax incentive programs similar to those that have effectively spurred the growth of distributed solar generation. Finally, creating a “Water Information Administration” modeled on the Energy Information Administration would provide robust scientific and economic information to foster a comprehensive and systemic understanding of the country’s changing water needs, including supply, demand by sector and end-use, and flows

Tell us about a research collaboration your group has undertaken.

I’m very excited about several new research collaborations here at Stanford and SLAC. The first uses SLAC’s beamline to perform high-fidelity operando measurements of concentration polarization and mass transfer rates in membrane-based processes using X-ray particle image velocimetry and confocal X-ray micro fluorescence techniques. We hope to use these measurements to better understand how concentration polarization limits performance in membrane separation processes, to validate CFD models of heat and mass transport in complex module geometries, and to design spacers and modules to promote mixing. I’m also excited to continue my collaboration with my colleague Ram Rajagopal to develop a cloud-coordinated platform for optimizing the operation of a wastewater treatment facility’s treatment, energy recovery (biogas generation), and energy storage units for maximum financial benefit.

What type of work can we look forward to seeing from you in the future?

I am very passionate about securing global water supplies while simultaneously accelerating the decarbonization of the water industry. We have forthcoming work on electrified alternatives to carbon-intensive aqueous separation processes, as well as work in managing water treatment plants to provide demand response services to the grid. I am also expanding my investment in understanding water-related constraints to deep decarbonization and we have a forthcoming manuscript on the energy and emission penalties of high salinity brine treatment from geologic carbon sequestration.

Read more about the winners in this editorial in ACS Sustainable Chemistry & Engineering. The winners will be recognized at the upcoming 2021 ACS Green Chemistry & Engineering Conference in keynote presentations.

ACS Editor’s Choice: How to Review a Paper — and More!

Each and every day, ACS grants free access to a new peer-reviewed research article from one of the Society’s journals. These articles are specially chosen by a team of scientific editors of ACS journals from around the world to highlight the transformative power of chemistry. Access to these articles will remain open to all as a public service.

Check out this week’s picks!
***
Selective Chemical Functionalization at N6-Methyladenosine Residues in DNA Enabled by Visible-Light-Mediated Photoredox Catalysis
J. Am. Chem. Soc. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/jacs.0c10616
***
Understanding the Structure and Dynamics of Complex Biomembrane Interactions by Neutron Scattering Techniques
Langmuir 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acs.langmuir.0c02516
***
Density Functional Theory and Experimental Determination of Band Gaps and Lattice Parameters in Kesterite Cu2ZnSn(SxSe1–x)4
J. Phys. Chem. Lett. 2020, 11, XXX, 10463–10468
DOI: 10.1021/acs.jpclett.0c03205
***
How to Review a Paper
ACS Chem. Health Saf. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acs.chas.0c00107
***
Controllable CO2 Capture in Metal–Organic Frameworks: Making Targeted Active Sites Respond to Light
Ind. Eng. Chem. Res. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acs.iecr.0c04126
***
Third-Generation W(CNAr)6 Photoreductants (CNAr = Fused-Ring and Alkynyl-Bridged Arylisocyanides)
Inorg. Chem. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acs.inorgchem.0c02912
***
Effects of Hydrogen on the Stacking Orientation of Bilayer Graphene Grown on Copper
Chem. Mater. 2020, XXXX, XXX, XXX-XXX
DOI: 10.1021/acs.chemmater.0c02331
***
Love ACS Editors’ Choice? Get a weekly e-mail of the latest ACS Editor’s Choice articles and never miss a breakthrough!

Discover Biology Journals from ACS Publications at SfN Global Connectome 

ACS Publications is proud to support the 2021 Society for Neuroscience (SfN) Global Connectome: A Virtual Event! This brand-new, cross-cutting digital neuroscience event, being held from January 11-13, 2021, is open to all neuroscientists and is designed to facilitate scientific exchange around the globe and across the field, providing scientists at all career stages with opportunities to learn, collaborate, and connect.

ACS Publications has a robust portfolio of research across the chemical neuroscience, neurochemistry, neurobiology, biology, and biological chemistry fields. These products and journals publish articles, special issues, virtual issues, calls for authorship, abstracts, posters and presentations, and more within the subject areas.

Connect with us on Monday, January 11th from 3:30 P.M. -4:00 P.M. (EST) for our SfN Global Connectome event: Findings on Psychedelics for Treating Mental Illness webinar. There will be three recorded flash talks from authors speaking about their exciting research in this area. Following the talks, ACS Chemical Neuroscience Interim Editor-in-Chief, Dr. Jacob Hooker, will be moderating a Q&A session.

Register for the webinar here!

Explore Highlights Below:

ACS Chemical Neuroscience

ACS Chemical Neuroscience publishes high-quality research articles and reviews that showcase chemical, quantitative biological, biophysical, and bioengineering approaches to understanding the nervous system and the development of new treatments for neurological disorders. Research in the journal focuses on aspects of chemical neurobiology and bio-neurochemistry.

DARK Classics in Chemical Neuroscience Volume II

DARK Classics in Chemical Neuroscience Volume I

CNS Pathogens: A Special Issue of ACS Chemical Neuroscience

Neurological Impacts of COVID-19 Explored in ACS Chemical Neuroscience

ACS Editors’ Choice: Physiological and Pathological Roles of Cdk5: Potential Directions for Therapeutic Targeting in Neurodegenerative DiseaseAnnamarie B. Allnutt, Ariana K. Waters, Santosh Kesari, and Venkata Mahidhar Yenugonda

ACS Editors’ Choice: Neurotensin Analogues Containing Cyclic Surrogates of Tyrosine at Position 11 Improve NTS2 Selectivity Leading to Analgesia without Hypotension and HypothermiaEmilie Eiselt, Simon Gonzalez, Charlotte Martin, Magali Chartier, Cecilia Betti, Jean-Michel Longpré, Florine Cavelier, Dirk Tourwé, Louis Gendron, Steven Ballet, and Philippe Sarret

ACS Pharmacology & Translational Science

ACS Pharmacology & Translational Science publishes high quality, innovative, and impactful research across the broad spectrum of biological sciences, covering basic and molecular sciences through to translational preclinical studies. Clinical studies that address novel mechanisms of action and methodological papers that provide innovation, and advance translation, will also be considered. We give priority to studies that fully integrate basic pharmacological and/or biochemical findings into physiological processes that have translational potential in a broad range of biomedical disciplines.

Special Issue: Advances in G Protein-Coupled Receptor Signal Transduction

GPCRs- G Protein-Coupled Receptors Virtual Issue

Viewpoint: Consciousness, Religion, and Gurus: Pitfalls of Psychedelic MedicineMatthew W. Johnson

Viewpoint: The Subjective Effects of Psychedelics May Not Be Necessary for Their Enduring Therapeutic EffectsDavid E. Olson

ACS Editors’ Choice: Discovery of a First-in-Class Potent Small Molecule Antagonist against the Adrenomedullin-2 ReceptorTimothy M. Skerry, et al.

ACS Chemical Biology

The journal serves as a forum to facilitate the communication between biologists and chemists that will translate into new research opportunities and discoveries. Results will be published in which molecular reasoning has been used to probe questions through in vitro investigations, cell biological methods, or organismic studies.

Most Read Articles

Special Issue Call for Papers: Chemical Glycobiology

Special Issue: Chemical Microbiology

Biochemistry


Biochemistry provides an international forum for publishing exceptional, rigorous, high-impact research across all of biological chemistry. This broad scope includes studies on the chemical, physical, mechanistic, and/or structural basis of biological or cell function. It encompasses the fields of chemical biology, synthetic biology, disease biology, cell biology, nucleic acid biology, neuroscience, structural biology, and biophysics.

Most Read Articles

Highlights from Biochemistry

2020 in Biochemistry Perspectives

Journal of Medicinal Chemistry

The Journal of Medicinal Chemistry publishes studies that contribute to understanding the relationship between molecular structure and biological activity or mode of action.

View Perspectives from Journal of Medicinal Chemistry

View Drug Annotations from Journal of Medicinal Chemistry

Read Excellence in Medicinal Chemistry Research from Japan Virtual Issue

ACS Infectious Diseases

The journal’s scope encompasses all aspects of chemistry relating to infectious diseases research, including research on pathogens, host-pathogen interactions, therapeutics, diagnostics, vaccines, drug-delivery systems, and other biomedical technology development pertaining to infectious diseases.

Most Read Articles

Read Key Resources for Medicinal Chemists Virtual Issue

View the Viewpoints from ACS Infectious Diseases

ACS Medicinal Chemistry Letters

The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules.

Most Read Articles

Read Women in Medicinal Chemistry Special Issue

Read Medicinal Chemistry: From Targets to Therapies Special Issue

Bioconjugate Chemistry

The journal’s mission is to communicate advances in fields, including therapeutic delivery, imaging, bionanotechnology, and synthetic biology. Bioconjugate Chemistry is intended to provide a forum for presenting research relevant to all aspects of bioconjugates, including the preparation, properties, and applications of biomolecular conjugates.

Celebrating 30 years of Bioconjugate Chemistry with Editor-in-Chief Vincent M. Rotello

Special Issue on Molecular Imaging

ACS Synthetic Biology

This journal publishes high-quality research that demonstrates integrative, molecular approaches enabling a better understanding of the organization and function of cells, tissues, and organisms in systems.

Most Read Articles

Reviews

Biology abstracts, posters, and presentations from ACS National Meetings

SciMeetings is a virtual science-sharing database developed by ACS Publications in collaboration with other ACS divisions. SciMeetings launched as a solution for sharing the science intended for the terminated ACS Spring 2020 event and serving as the archive for the ACS Fall 2020 Virtual Meeting. It offers presenters the benefit of a DOI, an open-access license, increased visibility, presenter accessible analytics, and more.

See the biology research from ACS Spring 2020 and ACS Fall 2020.

Call for Authorship: CRISPR/Cas9

ACS In Focus is a new series of brief, dynamic e-books designed to bring new graduate students up to speed on topics they need to know in their research. These works are also designed to introduce topics to scientists interested in bringing additional and often multidisciplinary perspectives into their research questions. CRISPR’s potential across STEM research is exploding, and the ACS In Focus editors are seeking an author or author team to write on the foundations around this topic.

Professor Craig W. Lindsley Named Editor-in-Chief of the Journal of Medicinal Chemistry

ACS Publications is pleased to announce that Craig W. Lindsley, Ph.D., has been named as Editor-in-Chief (EIC) of the Journal of Medicinal Chemistry. His term is set to begin on January 1, 2021. Lindsley is the William K. Warren, Jr., chair in medicine at Vanderbilt University. There, he is a University Professor of Pharmacology, Biochemistry, and Chemistry and the Principal Investigator at the Lindsley lab. Additionally, he was recently named as the Director of Vanderbilt University’s Warren Center for Neuroscience Drug Discovery.

His research group focuses on drug discovery, medicinal chemistry, and synthetic organic chemistry. Lindsley received his Ph.D. from the University of California, Santa Barbara. He was the founding EIC of ACS Chemical Neuroscience and is the interim EIC of ACS Pharmacology & Translational Science. A search for permanent editors-in-chief for those journals is underway now.

I recently sat down with Professor Lindsley to learn about his plans for the Journal of Medicinal Chemistry. Read the interview below.

What are your goals as Editor-in-Chief?

 I was thrilled beyond belief at being named the EIC of JMC – I looked up to Philip S. Portoghese (EIC of JMC for over 40 years!) since I was a graduate student, and to now have his former role may be the height of my professional career. The Journal of Medicinal Chemistry plays a critical role in not only disseminating the most important advances in small molecule drug discovery, but also in providing content that trains current and future generations of medicinal chemists – it all starts with JMC, and that legacy of impact will be retained and expanded.

My vision for the Journal of Medicinal Chemistry involves expanding the editorial board (geographic, ethnic, and gender balance along with establishing an Early Career Board), increasing author satisfaction, increasing and creating new non-peer-reviewed (citable) front matter content, increasing submissions, and expanding journal content to encompass more pharmacokinetics (DMPK) science and emerging areas within medicinal chemistry and drug discovery. JMC is the most trusted and cited medicinal chemistry journal in the world, and my highest priority is to preserve the legacy of JMC, while further expanding its scope, authorship, and impact.

Beyond this, my goals are to create an Early Career Board, build an editorial board that partners with authors to see their work published quickly (yet with high standards), build bridges to medicinal chemists in Europe, Asia, and India, and streamline the submission process and speed of publication.

Immediate plans center on revising/streamlining the Author Guidelines, expanding the EAB and adding new AEs (geographic, ethnic, and gender balance, along with establishing an Early Career Board), and actively soliciting authors and new content. Engaging all forms of social media will start immediately, and I hope to add a significant diversity of contributions in new front matter. I want JMC to be the first choice for authors to publish their medicinal chemistry research, and to enjoy the experience of publishing with JMC. Over the longer-term, I would like to see new authors find a home at JMC, active engagement by the Early Career Board, and despite Plan S, increased submissions from medicinal chemists in Europe and other underrepresented areas. To propel the Journal of Medicinal Chemistry to further expand its influence and impact in medicinal chemistry and drug discovery, I plan to increase JMC visibility, actively solicit content globally and embrace the next generation of medicinal chemists across gender and ethnic lines.

What do you see as the biggest challenges and opportunities in the field today?

The biggest challenges still reside with delivering clinical candidates rapidly, and with properties/profiles that enabled successful transition into patients – here as well, preclinical animal models still lack predictive validity in human disease. Many of the newer classes of therapeutic targets bring new structure-activity relationships and drug metabolism and DMPK challenges, and the strategies for successful engagement are just now appearing in JMC. Another issue is IP space and the need for fundamentally new heterocycles and other chemotypes to secure IP; however, these may also bring new DMPK challenges.

Why should people outside the field take an interest in JMC? How does it affect people’s lives? 

Everyone engaged in discovery and target validation should read JMC – biological and genetic proof of concept is great, but it always needs to be recapitulated with a small molecule. Perspectives are a great venue to learn everything about a given area, and always include multiple ‘teaching moments’.

Especially in light of a pandemic like Covid-19, JMC captures the latest advances and new therapeutic modalities being advanced to combat the global threat.

How do you see the journal and the community working together to address those challenges and seize those opportunities?

I see more engagement by pharmacologists/biochemists and virologists with medicinal chemists moving forward to move ‘in-step’ and advance fundamental new treatments. Moving forward, I would like to see more cross-over special issues with other journals within the ACS biological portfolio to raise awareness across disciplines.

Where do you want JMC to expand?

 Over the longer-term, I would like to see new authors find a home at JMC, active engagement by the Early Career Board, and despite Plan S, increased submissions from medicinal chemists in Europe and other geographic areas. I’d also like to see more engagement and submissions from medicinal chemists engaged with endemic diseases, as these still have a significant global health impact.

Browse the Most-Read Articles of October 2020

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles from each ACS Publications journal in October 2020, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Click on your favorite journal below to see their most-read articles of the month.

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Accounts of Chemical Research
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Palladium-Catalyzed Asymmetric Allylic C–H Functionalization: Mechanism, Stereo- and Regioselectivities, and Synthetic Applications
DOI: 10.1021/acs.accounts.0c00477

Total Synthesis of Daphniphyllum Alkaloids: From Bicycles to Diversified Caged Structures
DOI: 10.1021/acs.accounts.0c00532

Chiral Induced Spin Selectivity Gives a New Twist on Spin-Control in Chemistry
Open Access Through ACS Author Choice
DOI: 10.1021/acs.accounts.0c00485

Phosphangulene: A Molecule for All Chemists
DOI: 10.1021/acs.accounts.0c00511

Excitons and Polarons in Organic Materials
DOI: 10.1021/acs.accounts.0c00349


Accounts of Materials Research
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Hydrogen-Bonded Organic Frameworks: A Rising Class of Porous Molecular Materials
DOI: 10.1021/accountsmr.0c00019

Interfacial Assembly Directed Unique Mesoporous Architectures: From Symmetric to Asymmetric
DOI: 10.1021/accountsmr.0c00028

Nanoscale Cinematography of Soft Matter System under Liquid-Phase TEM
DOI: 10.1021/accountsmr.0c00013

Enhancements in the Mechanical Stretchability and Thermoelectric Properties of PEDOT:PSS for Flexible Electronics Applications
DOI: 10.1021/accountsmr.0c00021

Structural Engineering of Eu2-Doped Silicates Phosphors for LED Applications
DOI: 10.1021/accountsmr.0c00014


ACS Applied Bio Materials
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Point-of-Care Biosensor-Based Diagnosis of COVID-19 Holds Promise to Combat Current and Future Pandemics
DOI: 10.1021/acsabm.0c01083

Bacteria-Inspired Nanomedicine
DOI: 10.1021/acsabm.0c01072

Hierarchical Targeted Delivery of Lonidamine and Camptothecin Based on the Ultra-Rapid pH/GSH Response Nanoparticles for Synergistic Chemotherapy
DOI: 10.1021/acsabm.0c01207

Electrochemical SARS-CoV-2 Sensing at Point-of-Care and Artificial Intelligence for Intelligent COVID-19 Management
DOI: 10.1021/acsabm.0c01004

Designer, Programmable 3D DNA Nanodevices to Probe Biological Systems
DOI: 10.1021/acsabm.0c00916


ACS Applied Electronic Materials
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Recent Advances in the Electromagnetic Interference Shielding of 2D Materials beyond Graphene
DOI: 10.1021/acsaelm.0c00545

Tunable Electronic Properties and Large Rashba Splittings Found in Few-Layer Bi2Se3/PtSe2 Van der Waals Heterostructures
Open Access Through ACS Author Choice
DOI: 10.1021/acsaelm.0c00638

Recent Advancements in Near-Infrared Perovskite Light-Emitting Diodes
DOI: 10.1021/acsaelm.0c00825

Influence of Oxygen Content on the Structure and Reliability of Ferroelectric HfxZr1–xO2 Layers
DOI: 10.1021/acsaelm.0c00680

Organic Memristive Devices Based on Squaraine Nanowires
DOI: 10.1021/acsaelm.0c00652


ACS Applied Energy Materials
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Tetrahedral Distortion and Thermoelectric Performance of the Ag-Substituted CuInTe2 Chalcopyrite Compound
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsaem.0c01867

Double-Sided Heat-Exchange CBD System for Homogeneous Zn(O,S) Thin Films in Highly Efficient CIGS Solar Devices
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsaem.0c02154

Different Photostability of BiVO4 in Near-pH-Neutral Electrolytes
Open Access Through ACS Author Choice
DOI: 10.1021/acsaem.0c01904

MXene-Derived Bilayered Vanadium Oxides with Enhanced Stability in Li-Ion Batteries
DOI: 10.1021/acsaem.0c01906

Evaluating the Impact of Tailored Water Wettability on Performance of CO2 Capture
DOI: 10.1021/acsaem.0c01603


ACS Applied Materials & Interfaces
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3D Biomimetic Tongue-Emulating Surfaces for Tribological Applications
Open Access Through ACS Author Choice
DOI: 10.1021/acsami.0c12925

Highly Conducting Nanographite-Filled Paper Fabricated via Standard Papermaking Techniques
Open Access Through ACS Author Choice
DOI: 10.1021/acsami.0c13086

A Hydrogel-Integrated Culture Device to Interrogate T Cell Activation with Physicochemical Cues
Open Access Through ACS Author Choice
DOI: 10.1021/acsami.0c16478

In Situ Generation of Regularly Ordered 2D Ultrathin Covalent Organic Framework Films for Highly Sensitive Photoelectrochemical Bioanalysis
DOI: 10.1021/acsami.0c15147

Superhydrophobic Antireflection Coating on Glass Using Grass-like Alumina and Fluoropolymer
Open Access Through ACS Author Choice
DOI: 10.1021/acsami.0c12465


ACS Applied Nano Materials
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Nanomaterials-Based Membranes Increase Flux and Selectivity to Enable Chemical Separations
DOI: 10.1021/acsanm.0c02471

Control Synthesis and Alloying of Ambient Stable Pb-Free Cs3Bi2Br9(1–x)I9x (0 ≤ x ≤ 1) Perovskite Nanocrystals for Photodetector Application
DOI: 10.1021/acsanm.0c02288

Multiphoton-Excited Deep-Ultraviolet Photolithography for 3D Nanofabrication
DOI: 10.1021/acsanm.0c02519

Core/Shell PDA@UiO-66 Metal–Organic Framework Nanoparticles for Efficient Visible-Light Photodegradation of Organic Dyes
DOI: 10.1021/acsanm.0c02636

High Axial and Lateral Resolutions on Self-Assembled Gold Nanoparticle Metasurfaces for Live-Cell Imaging
DOI: 10.1021/acsanm.0c02300


ACS Applied Polymer Materials
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Polymers for Photothermal Applications in Biology
DOI: 10.1021/acsapm.0c00994

Conjugated Polymers for Photon-to-Electron and Photon-to-Fuel Conversions
DOI: 10.1021/acsapm.0c00791

Skin-Inspired Hydrogel-Elastomer Hybrid Forms a Seamless Interface by Autonomous Hetero-Self-Healing
DOI: 10.1021/acsapm.0c00925

Organic Solar Cells with Large Insensitivity to Donor Polymer Molar Mass across All Acceptor Classes
DOI: 10.1021/acsapm.0c01041

Formation of Supramolecular Polymer Network and Single-Chain Polymer Nanoparticles via Host–Guest Complexation from Pillar[5]arene Pendant Polymer
DOI: 10.1021/acsapm.0c00971


ACS Biomaterials Science & Engineering
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FRESH 3D Bioprinting a Full-Size Model of the Human Heart
DOI: 10.1021/acsbiomaterials.0c01133

Functional DNA Based Hydrogels: Development, Properties and Biological Applications
DOI: 10.1021/acsbiomaterials.0c01125

Elastomer-Grafted iPSC-Derived Micro Heart Muscles to Investigate Effects of Mechanical Loading on Physiology
DOI: 10.1021/acsbiomaterials.0c00318

Electroresponsive Alginate-Based Hydrogels for Controlled Release of Hydrophobic Drugs
DOI: 10.1021/acsbiomaterials.0c01400

Phenomenology of the Initial Burst Release of Drugs from PLGA Microparticles
DOI: 10.1021/acsbiomaterials.0c01228


ACS Catalysis
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Catalytic, Metal-Free Amide Synthesis from Aldehydes and Imines Enabled by a Dual-Catalyzed Umpolung Strategy under Redox-Neutral Conditions
DOI: 10.1021/acscatal.0c04070

Design and Implementation of a Catalytic Electron Donor–Acceptor Complex Platform for Radical Trifluoromethylation and Alkylation
DOI: 10.1021/acscatal.0c03837

Photoredox and Weak Brønsted Base Dual Catalysis: Alkylation of -Thio Alkyl Radicals
DOI: 10.1021/acscatal.0c03851

Recent Methodologies That Exploit Oxidative Addition of C–N Bonds to Transition Metals
DOI: 10.1021/acscatal.0c03341

Strategies for the Catalytic Enantioselective Synthesis of -Trifluoromethyl Amines
DOI: 10.1021/acscatal.0c03569


ACS Central Science
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Too Many Materials and Too Many Applications: An Experimental Problem Waiting for a Computational Solution
Open Access through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c00988

Development of a Platform for Near-Infrared Photoredox Catalysis
Open Access through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c00948

Fighting COVID-19 Using Molecular Dynamics Simulations
Open Access through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c01236

Synthetic Elaboration of Native DNA by RASS (SENDR)
Open Access through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c00680 

From Molecules to Porous Materials: Integrating Discrete Electrocatalytic Active Sites into Extended Frameworks
Open Access through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c01088


ACS Chemical Biology
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An Allosteric Modulator of RNA Binding Targeting the N-Terminal Domain of TDP-43 Yields Neuroprotective Properties
DOI: 10.1021/acschembio.0c00494

Isopedopeptins A–H: Cationic Cyclic Lipodepsipeptides from Pedobacter cryoconitis UP508 Targeting WHO Top-Priority Carbapenem-Resistant Bacteria
Open Access through ACS AuthorChoice
DOI: 10.1021/acschembio.0c00568

Daniel S. Kemp (1936–2020): A Pioneer of Bioorganic Chemistry
DOI: 10.1021/acschembio.0c00589 

Garcinol Is an HDAC11 Inhibitor
DOI: 10.1021/acschembio.0c00719

Halogenation-Dependent Effects of the Chlorosulfolipids of Ochromonas danica on Lipid Bilayers
DOI: 10.1021/acschembio.0c00624


ACS Chemical Health & Safety
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Machine Learning and Deep Learning in Chemical Health and Safety: A Systematic Review of Techniques and Applications
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.chas.0c00075

Development of a Headspace Sampling–Gas Chromatography–Mass Spectrometry Method for the Analysis of Fireground Contaminants on Firefighter Turnout Materials
DOI: 10.1021/acs.chas.0c00041

Creating a Positive, Community-Based Learning Environment in a Chemistry Department
DOI: 10.1021/acs.chas.0c00033


ACS Chemical Neuroscience
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Western Diet Accelerates the Impairment of Odor-Related Learning and Olfactory Memory in the Mouse
Open Access through ACS AuthorChoice
DOI: 10.1021/acschemneuro.0c00466

Screening and Cellular Characterization of Genetically Encoded Voltage Indicators Based on Near-Infrared Fluorescent Proteins
DOI: 10.1021/acschemneuro.0c00046

NeuroChat with Dr. Paul A. Newhouse
DOI: 10.1021/acschemneuro.0c00560

Sowing the Seeds of Discovery: Tau-Propagation Models of Alzheimer’s Disease
DOI: 10.1021/acschemneuro.0c00531
 

Exploring Stereochemical and Conformational Requirements at Cannabinoid Receptors for Synthetic Cannabinoids Related to SDB-006, 5F-SDB-006, CUMYL-PICA, and 5F-CUMYL-PICA
DOI: 10.1021/acschemneuro.0c00591


ACS Combinatorial Science
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Solution-Phase Fmoc-Based Peptide Synthesis for DNA-Encoded Chemical Libraries: Reaction Conditions, Protecting Group Strategies, and Pitfalls
Open Access through ACS AuthorChoice
DOI: 10.1021/acscombsci.0c00144

Detection of Thiol Functionality and Disulfide Bond Formation by Polyoxometalate
DOI: 10.1021/acscombsci.0c00176

Cautionary Guidelines for Machine Learning Studies with Combinatorial Datasets
DOI: 10.1021/acscombsci.0c00118

Progress in Natural Compounds/siRNA Co-delivery Employing Nanovehicles for Cancer Therapy
DOI: 10.1021/acscombsci.0c00099

Sorting Technology for Circulating Tumor Cells Based on Microfluidics
DOI: 10.1021/acscombsci.0c00157


ACS Earth and Space Chemistry
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Leaf Stomatal Control over Acyl Peroxynitrate Dry Deposition to Trees
DOI: 10.1021/acsearthspacechem.0c00152

On the Importance of Surface-Enhanced Renoxification as an Oxides of Nitrogen Source in Rural and Urban New York State      Open Access through ACS AuthorChoice
DOI: 10.1021/acsearthspacechem.0c00185

Kinetics and Mechanisms of Hydrothermal Ketonic Decarboxylation
DOI: 10.1021/acsearthspacechem.0c00189

Aqueous Uranium Speciation on U/Ca in Foraminiferal Calcite: The Importance of Minor Species—UO2(CO3)22–
DOI: 10.1021/acsearthspacechem.0c00211

Transformation of Ferrihydrite to Goethite and the Fate of Plutonium
DOI: 10.1021/acsearthspacechem.0c00195       


ACS Energy Letters
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How Comparable Are Sodium-Ion Batteries to Lithium-Ion Counterparts?
DOI: 10.1021/acsenergylett.0c02181

Promising All-Solid-State Batteries for Future Electric Vehicles
DOI: 10.1021/acsenergylett.0c01977

Hidden in Plain Sight: The Overlooked Influence of the Cs+ Substructure on Transformations in Cesium Lead Halide Nanocrystals
DOI: 10.1021/acsenergylett.0c02029

Solution-Processable Covalent Organic Framework Electrolytes for All-Solid-State Li–Organic Batteries
DOI: 10.1021/acsenergylett.0c01889

Thermally Stable Passivation toward High Efficiency Inverted Perovskite Solar Cells
DOI: 10.1021/acsenergylett.0c01813


ACS Environmental Science & Technology Water
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Ion-Exchange Materials for Membrane Capacitive Deionization
Open Access through ACS AuthorChoice
DOI: 10.1021/acsestwater.0c00123

The Mobility of Plastic Nanoparticles in Aqueous and Soil Environments: A Critical Review
Open Access through ACS AuthorChoice
DOI: 10.1021/acsestwater.0c00130

Occurrence of CX3R-Type Disinfection Byproducts in Drinking Water Treatment Plants Using DON-Rich Source Water
DOI: 10.1021/acsestwater.0c00051

Activity and Water Footprint of Unconventional Energy Production under Hydroclimate Variation in Colorado
DOI: 10.1021/acsestwater.0c00064

Defluviicoccus vanus Glycogen-Accumulating Organisms (DvGAOs) Are Less Competitive Than Polyphosphate-Accumulating Organisms (PAOs) at High Temperature
DOI: 10.1021/acsestwater.0c00092


ACS ES&T Engineering
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Environmental Materials beyond and below the Nanoscale: Single-Atom Catalysts
DOI: 10.1021/acsestengg.0c00136

Wetting, Scaling, and Fouling in Membrane Distillation: State-of-the-Art Insights on Fundamental Mechanisms and Mitigation Strategies
DOI: 10.1021/acsestengg.0c00025

Farm-to-Tap Water Treatment: Naturally-Sourced Photosensitizers for Enhanced Solar Disinfection of Drinking Water
DOI: 10.1021/acsestengg.0c00067

Launch of ACS ES&T Engineering and Redefining Environmental Engineering
Open Access through ACS Free to Read License
DOI: 10.1021/acsestengg.0c00130

Mechanistic Investigations of the Pyridinic N–Co Structures in Co Embedded N-Doped Carbon Nanotubes for Catalytic Ozonation
DOI: 10.1021/acsestengg.0c00004


ACS Infectious Diseases
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Synthesis and Structure–Activity Relationship of Dehydrodieugenol B Neolignans against Trypanosoma cruzi
Open Access through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.0c00523

Call for Papers: Antibiotic Alternatives Special Issue
DOI: 10.1021/acsinfecdis.0c00663

Targeted Covalent Inhibitors for the Treatment of Malaria?
DOI: 10.1021/acsinfecdis.0c00684

Chemical Control of Quorum Sensing in E. coli: Identification of Small Molecule Modulators of SdiA and Mechanistic Characterization of a Covalent Inhibitor
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsinfecdis.0c00654

Inhibition of Influenza Virus Polymerase by Interfering with Its Protein–Protein Interactions
DOI: 10.1021/acsinfecdis.0c00552


ACS Macro Letters
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100th Anniversary of Macromolecular Science Viewpoint: Toward Catalytic Chemical Recycling of Waste (and Future) Plastics
DOI: 10.1021/acsmacrolett.0c00582

Elastomers without Covalent Cross-Linking: Concatenated Rings Giving Rise to Elasticity
DOI: 10.1021/acsmacrolett.0c00635

Photoexcitation of Grubbs’ Second-Generation Catalyst Initiates Frontal Ring-Opening Metathesis Polymerization
DOI: 10.1021/acsmacrolett.0c00486

Stress Relaxation and Underlying Structure Evolution in Tough and Self-Healing Hydrogels
DOI: 10.1021/acsmacrolett.0c00600

100th Anniversary of Macromolecular Science Viewpoint: Block Copolymers with Tethered Acid Groups: Challenges and Opportunities
DOI: 10.1021/acsmacrolett.0c00629


ACS Materials Letters
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Super Moisture Absorbent Gels for Sustainable Agriculture via Atmospheric Water Irrigation
DOI: 10.1021/acsmaterialslett.0c00439

Synthesis of Imine-Based Covalent Organic Frameworks Catalyzed by Metal Halides and in Situ Growth of Perovskite@COF Composites
DOI: 10.1021/acsmaterialslett.0c00376

Self-Driven “Microfiltration” Enabled by Porous Superabsorbent Polymer (PSAP) Beads for Biofluid Specimen Processing and Storage
Open Access through ACS AuthorChoice
DOI: 10.1021/acsmaterialslett.0c00348

Single-Atom Electrocatalysts for Lithium Sulfur Batteries: Progress, Opportunities, and Challenges
DOI: 10.1021/acsmaterialslett.0c00396

Hyperfluorescence-Based Emission in Purely Organic Materials: Suppression of Energy-Loss Mechanisms via Alignment of Triplet Excited States
DOI: 10.1021/acsmaterialslett.0c00407


ACS Medicinal Chemistry Letters
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Presenting a Special Issue on “Medicinal Chemistry: From Targets to Therapies”
This article is part of the Medicinal Chemistry: From Targets to Therapies special issue.
DOI: 10.1021/acsmedchemlett.0c00508

Novel Heteroaryl Compounds for Treating Huntington’s Disease
DOI: 10.1021/acsmedchemlett.0c00529

Novel CDK2 Inhibitors for Treating Cancer
DOI: 10.1021/acsmedchemlett.0c00500

Hydrogen Peroxide Inducible JAK3 Covalent Inhibitor: Prodrug for the Treatment of RA with Enhanced Safety Profile
DOI: 10.1021/acsmedchemlett.0c00323

Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2
Open Access through ACS AuthorChoice
DOI: 10.1021/acsmedchemlett.0c00521


ACS Nano
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What Went Wrong with Anticancer Nanomedicine Design and How to Make It Right
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsnano.9b09713

Antimicrobial Nanomaterials and Coatings: Current Mechanisms and Future Perspectives to Control the Spread of Viruses Including SARS-CoV-2        
DOI: 10.1021/acsnano.0c05937

COVID-19 Vaccine Frontrunners and Their Nanotechnology Design
DOI: 10.1021/acsnano.0c07197

Conductive Hydrogel for a Photothermal-Responsive Stretchable Artificial Nerve and Coalescing with a Damaged Peripheral Nerve
DOI: 10.1021/acsnano.0c05197

Nanoporous Boron Nitride Aerogel Film and Its Smart Composite with Phase Change Materials
DOI: 10.1021/acsnano.0c05931


ACS Omega
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Inhibiting CDK6 Activity by Quercetin Is an Attractive Strategy for Cancer Therapy
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c03975

Quantitative Structure–Activity Relationship Machine Learning Models and their Applications for Identifying Viral 3CLpro- and RdRp-Targeting Compounds as Potential Therapeutics for COVID-19 and Related Viral Infections          
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c03682

Bioinformatic Analysis and Biophysical Characterization Reveal Structural Disorder in G0S2 Protein
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c03171

Inhibiting CDK6 Activity by Quercetin Is an Attractive Strategy for Cancer Therapy
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c03975

Pivotal Role of Heteroatoms in Improving the Corrosion Inhibition Ability of Thiourea Derivatives
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c04241


ACS Pharmacology & Translational Science
***

Virtual and In Vitro Antiviral Screening Revive Therapeutic Drugs for COVID-19
DOI: 10.1021/acsptsci.0c00131

RNA Targeting in Acute Myeloid Leukemia
DOI: 10.1021/acsptsci.0c00120

Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV-2 Main Protease Inhibitors
DOI: 10.1021/acsptsci.0c00130

Heterodimeric Insecticidal Peptide Provides New Insights into the Molecular and Functional Diversity of Ant Venoms
DOI: 10.1021/acsptsci.0c00119

Development of a High-Throughput Homogeneous AlphaLISA Drug Screening Assay for the Detection of SARS-CoV-2 Nucleocapsid
DOI: 10.1021/acsptsci.0c00122


ACS Photonics
***

A Critical Review on Ultraviolet Disinfection Systems against COVID-19 Outbreak: Applicability, Validation, and Safety Considerations
DOI: 10.1021/acsphotonics.0c01245

Generation of Pure OAM Beams with a Single State of Polarization by Antenna-Decorated Microdisk Resonators
Open Access through ACS AuthorChoice
DOI: 10.1021/acsphotonics.0c01081

Effect of Ag Nanocube Optomechanical Modes on Plasmonic Surface Lattice Resonances
Open Access through ACS AuthorChoice
DOI: 10.1021/acsphotonics.0c01187

Reconfigurable Multistate Optical Systems Enabled by VO2 Phase Transitions
Open Access through ACS AuthorChoice
DOI: 10.1021/acsphotonics.0c01241     

Lanthanide-Based Nanosensors: Refining Nanoparticle Responsiveness for Single Particle Imaging of Stimuli
DOI: 10.1021/acsphotonics.0c00894


ACS Sensors
***

Engineering Protein Switches for Rapid Diagnostic Tests
Open Access through ACS AuthorChoice
DOI: 10.1021/acssensors.0c01831

Visualizing Peroxynitrite in Microvessels of the Brain with Stroke Using an Engineered Highly Specific Fluorescent Probe
DOI: 10.1021/acssensors.0c01555

Moving Electrode Impedance Spectroscopy for Accurate Conductivity Measurements of Corrosive Ionic Media
Open Access through ACS AuthorChoice
DOI: 10.1021/acssensors.0c01465

Integrated Bioaerosol Sampling/Monitoring Platform: Field-Deployable and Rapid Detection of Airborne Viruses
DOI: 10.1021/acssensors.0c01531

High-Performance Ultrafast Humidity Sensor Based on Microknot Resonator-Assisted Mach–Zehnder for Monitoring Human Breath
DOI: 10.1021/acssensors.0c00863


ACS Sustainable Chemistry & Engineering
***

Expectations for Manuscripts Contributing to the Field of Solvents in ACS Sustainable Chemistry & Engineering
DOI: 10.1021/acssuschemeng.0c06901

A Glove-Box- and Schlenk-Line-Free Protocol for Solid-State C–N Cross-Coupling Reactions Using Mechanochemistry
DOI: 10.1021/acssuschemeng.0c05834

Chemical Recycling of Aliphatic Polyamides by Microwave-Assisted Hydrolysis for Efficient Monomer Recovery
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.0c05706

Direct Quantification of Lignin in Liquors by High Performance Thin Layer Chromatography-Densitometry and Multivariate Calibration
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.0c03950

New Insights into Silicon Purification by Alloying–Leaching Refining: A Comparative Study of Mg–Si, Ca–Si, and Ca–Mg–Si Systems
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.0c05564


ACS Synthetic Biology
***

Genetically Encoded Fluorescent Biosensor for Rapid Detection of Protein Expression
DOI: 10.1021/acssynbio.0c00407

Design of Multipartite Transcription Factors for Multiplexed Logic Genome Integration Control in Mammalian Cells
Open Access through ACS AuthorChoice
DOI: 10.1021/acssynbio.0c00413

Tunable Gene Expression System Independent of Downstream Coding Sequence
DOI: 10.1021/acssynbio.0c00029

A RAGE Based Strategy for the Genome Engineering of the Human Respiratory Pathogen Mycoplasma pneumoniae
Open Access through ACS AuthorChoice
DOI: 10.1021/acssynbio.0c00263

Compartmentalizing Cell-Free Systems: Toward Creating Life-Like Artificial Cells and Beyond
DOI: 10.1021/acssynbio.0c00433


Analytical Chemistry
***

A Scientist’s Guide to Buying a 3D Printer: How to Choose the Right Printer for Your Laboratory
DOI: 10.1021/acs.analchem.0c03299

A 3-in-1 Hand-Held Ambient Mass Spectrometry Interface for Identification and 2D Localization of Chemicals on Surfaces
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.analchem.0c02615

Automated Annotation of Sphingolipids Including Accurate Identification of Hydroxylation Sites Using MSn Data
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.analchem.0c03016

Redesigning Solvatochromic Probe Laurdan for Imaging Lipid Order Selectively in Cell Plasma Membranes
DOI: 10.1021/acs.analchem.0c03559

Rapid Differential Diagnosis of Seven Human Respiratory Coronaviruses Based on Centrifugal Microfluidic Nucleic Acid Assay
DOI: 10.1021/acs.analchem.0c03364


Biochemistry
***

Revealing USP7 Deubiquitinase Substrate Specificity by Unbiased Synthesis of Ubiquitin Tagged SUMO2
DOI: 10.1021/acs.biochem.0c00701

Peptide-Based Approach to Inhibition of the Multidrug Resistance Efflux Pump AcrB
DOI: 10.1021/acs.biochem.0c00417

Flexible Synthetic Carbohydrate Receptors as Inhibitors of Viral Attachment
DOI: 10.1021/acs.biochem.0c00732

Assembly and Characterization of RNA/DNA Hetero-G-Quadruplexes
DOI: 10.1021/acs.biochem.0c00657

Activation Microswitches in Adenosine Receptor A2A Function as Rheostats in the Cell Membrane
DOI: 10.1021/acs.biochem.0c00626


Bioconjugate Chemistry
***

Gold Nanoclusters-Decorated Zeolitic Imidazolate Frameworks with Reactive Oxygen Species Generation for Photoenhanced Antibacterial Study   
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.bioconjchem.0c00485

Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay
DOI: 10.1021/acs.bioconjchem.0c00507

One-Step Protein–Polymer Conjugates from Boronic-Acid-Functionalized Polymers
DOI: 10.1021/acs.bioconjchem.0c00516

Synthetic Multienzyme Complexes Assembled on Virus-like Particles for Cascade Biosynthesis In Cellulo
DOI: 10.1021/acs.bioconjchem.0c00476

Powerful Chemiluminescence Probe for Rapid Detection of Prostate Specific Antigen Proteolytic Activity: Forensic Identification of Human Semen
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.bioconjchem.0c00500


Biomacromolecules
***

Fabrication of Double-Network Hydrogels with Universal Adhesion and Superior Extensibility and Cytocompatibility by One-Pot Method
DOI: 10.1021/acs.biomac.0c00822

Facile Synthesis of Poly(ethylene oxide)-Based Self-Healable Dynamic Triblock Copolymer Hydrogels
DOI: 10.1021/acs.biomac.0c01140

Click Synthesis of Size- and Shape-Tunable Star Polymers with Functional Macrocyclic Cores for Synergistic DNA Complexation and Delivery
DOI: 10.1021/acs.biomac.0c01283

Tunable LCST/UCST-Type Polypeptoids and Their Structure–Property Relationship
DOI: 10.1021/acs.biomac.0c01177

Effective Permeation of Anticancer Drugs into Glioblastoma Spheroids via Conjugation with a Sulfobetaine Copolymer       
DOI: 10.1021/acs.biomac.0c01200


Chemical Research in Toxicology
***

Electronic Cigarettes Are Chemical Reactors: Implication to Toxicity
DOI: 10.1021/acs.chemrestox.0c00412

Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury
Open Access Through ACS Author Choice
DOI: 10.1021/acs.chemrestox.0c00412

Harnessing In Silico, In Vitro, and In Vivo Data to Understand the Toxicity Landscape of Polycyclic Aromatic Compounds (PACs)
DOI: 10.1021/acs.chemrestox.0c00213

Nuclear and Cytoplasmic Functions of Vitamin C
Open Access Through ACS Author Choice
DOI: 10.1021/acs.chemrestox.0c00348

Proteomics Study of DNA–Protein Crosslinks in Methylmethanesulfonate and Fe2+-EDTA-Exposed Human Cells
DOI: 10.1021/acs.chemrestox.0c00289


Chemical Reviews
***

Fundamentals, Applications, and Future Directions of Bioelectrocatalysis
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.chemrev.0c00472

Single-Atom Catalysts across the Periodic Table
DOI: 10.1021/acs.chemrev.0c00576

Destruction of Metal–Organic Frameworks: Positive and Negative Aspects of Stability and Lability
DOI: 10.1021/acs.chemrev.0c00722

Electrochemical Oxidation Induced Selective C–C Bond Cleavage
DOI: 10.1021/acs.chemrev.0c00335

Light-Triggered Click Chemistry
DOI: 10.1021/acs.chemrev.0c00799


Chemistry of Materials
***

Colloidal Synthesis of Laterally Confined Blue-Emitting 3.5 Monolayer CdSe Nanoplatelets
Open Access Through ACS Author Choice
DOI: 10.1021/acs.chemmater.0c03066

Covalent Organic Framework Nanosheets Embedding Single Cobalt Sites for Photocatalytic Reduction of Carbon Dioxide
DOI: 10.1021/acs.chemmater.0c01642

Understanding the Activation of ZSM-5 by Phosphorus: Localizing Phosphate Groups in the Pores of Phosphate-Stabilized ZSM-5
Open Access Through ACS Author Choice
DOI: 10.1021/acs.chemmater.0c03411

From LiNiO2 to Li2NiO3: Synthesis, Structures and Electrochemical Mechanisms in Li-Rich Nickel Oxides
DOI: 10.1021/acs.chemmater.0c02880

Cooperative Aggregations of Nitrogen-Containing Perylene Diimides Driven by Rigid and Flexible Functional Groups
DOI: 10.1021/acs.chemmater.0c01888


Crystal Growth & Design
***

Crystalline Molecular Materials: From Structure to Function
DOI: 10.1021/acs.cgd.0c01360

Encapsulation of Aromatic Compounds and a Non-Aromatic Herbicide into a Gadolinium-Based Metal–Organic Framework via the Crystalline Sponge Method
DOI: 10.1021/acs.cgd.0c00901

A Doubly Interpenetrated CuII Metal–Organic Framework for Selective Molecular Recognition of Nitroaromatics
DOI: 10.1021/acs.cgd.0c00710

Numerical Frameworks for Laser-Induced Cavitation: Is Interface Supersaturation a Plausible Primary Nucleation Mechanism?
Open Access Through ACS Author Choice
DOI: 10.1021/acs.cgd.0c00942

Mixed-Ligand Strategy for the Construction of Photochromic Metal–Organic Frameworks Driven by Electron-Transfer Between Nonphotoactive Units
DOI: 10.1021/acs.cgd.0c01018


Energy & Fuels
***

Organic Flow Batteries: Recent Progress and Perspectives
DOI: 10.1021/acs.energyfuels.0c02855

Highly Selective Conversion from Alkali Lignin to Phenolic Products
DOI: 10.1021/acs.energyfuels.0c03098

Review on Magnetic Adsorbents for Removal of Elemental Mercury from Flue Gas
DOI: 10.1021/acs.energyfuels.0c02931

Vacuum Pyrolysis of Hybrid Poplar Milled Wood Lignin with Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry Analysis of Feedstock and Products for the Elucidation of Reaction Mechanisms
DOI: 10.1021/acs.energyfuels.0c02928

Influence of pH on Acidic Oil–Brine–Carbonate Adhesion Using Atomic Force Microscopy
DOI: 10.1021/acs.energyfuels.0c02494


Environmental Science & Technology
***

Are Fluoropolymers Really of Low Concern for Human and Environmental Health and Separate from Other PFAS?
DOI: 10.1021/acs.est.0c03244

Nanoplastics Disturb Nitrogen Removal in Constructed Wetlands: Responses of Microbes and Macrophytes
DOI: 10.1021/acs.est.0c03324

Cost and Life-Cycle Greenhouse Gas Implications of Integrating Biogas Upgrading and Carbon Capture Technologies in Cellulosic Biorefineries
DOI: 10.1021/acs.est.0c02816

Nonradical Oxidation of Pollutants with Single-Atom-Fe(III)-Activated Persulfate: Fe(V) Being the Possible Intermediate Oxidant
DOI: 10.1021/acs.est.0c04867

Surface-Enhanced Raman Spectroscopy Facilitates the Detection of Microplastics <1 μm in the Environment
DOI: 10.1021/acs.est.0c02317


Environmental Science & Technology Letters
***

Persistence of SARS-CoV-2 in Water and Wastewater
DOI: 10.1021/acs.estlett.0c00730

High Concentrations of Unidentified Extractable Organofluorine Observed in Blubber from a Greenland Killer Whale (Orcinus orca)
Open Access Through ACS Author Choice
DOI: 10.1021/acs.estlett.0c00661

Analysis of Fecal Sludges Reveals Common Enteric Pathogens in Urban Maputo, Mozambique
Open Access Through ACS Author Choice
DOI: 10.1021/acs.estlett.0c00610

Population-Wide Exposure to Per- and Polyfluoroalkyl Substances from Drinking Water in the United States
DOI: 10.1021/acs.estlett.0c00713

Evaluating the Removal of Per- and Polyfluoroalkyl Substances from Contaminated Groundwater with Different Adsorbents Using a Suspect Screening Approach
DOI: 10.1021/acs.estlett.0c00736


Industrial & Engineering Chemistry Research
***

Investigation of the Effect of the Regenerative Heat Exchanger on the Performance of Organic Rankine Cycles Using Perturbed Chain–Statistical Associating Fluid Theory Equation of State
Open Access Through ACS Author Choice
DOI: 10.1021/acs.iecr.0c03782

Poly(methylvinylsiloxane)-Based High Internal Phase Emulsion-Templated Materials (polyHIPEs)—Preparation, Incorporation of Palladium, and Catalytic Properties
Open Access Through ACS Author Choice
DOI: 10.1021/acs.iecr.0c03429

Deep-Learning Architecture in QSPR Modeling for the Prediction of Energy Conversion Efficiency of Solar Cells
DOI: 10.1021/acs.iecr.0c03880

Preparation of Metal–Organic Framework/Polyvinylidene Fluoride Mixed Matrix Membranes for Water Treatment
DOI: 10.1021/acs.iecr.0c03648

Temperature Influence in Real-Time Monitoring of Fed-Batch Ethanol Fermentation by Mid-Infrared Spectroscopy
DOI: 10.1021/acs.iecr.0c03717


Inorganic Chemistry
***

Porous Metal–Organic Polyhedra: Morphology, Porosity, and Guest Binding
Open Access Through ACS Author Choice
DOI: 10.1021/acs.inorgchem.0c01935

Light-Controlled Reactivity of Metal Complexes
DOI: 10.1021/acs.inorgchem.0c02791

N-Heterocyclic Carbene Gold(I) Complexes: Mechanism of the Ligand Scrambling Reaction and Their Oxidation to Gold(III) in Aqueous Solutions
Open Access Through ACS Author Choice
DOI: 10.1021/acs.inorgchem.0c02298

Water Molecule-Induced Reversible Magnetic Switching in a Bis-Terpyridine Cobalt(II) Complex Exhibiting Coexistence of Spin Crossover and Orbital Transition Behaviors
DOI: 10.1021/acs.inorgchem.0c00818

Metal-Dependent Cytotoxic and Kinesin Spindle Protein Inhibitory Activity of Ru, Os, Rh, and Ir Half-Sandwich Complexes of Ispinesib-Derived Ligands
Open Access Through ACS Author Choice
DOI: 10.1021/acs.inorgchem.0c00957


Journal of Agricultural and Food Chemistry
***

Red Beetroot Betalains: Perspectives on Extraction, Processing, and Potential Health Benefits
DOI: 10.1021/acs.jafc.0c04241

Liquid Chromatography–Mass Spectrometry-Based Metabolomics for Understanding the Compositional Changes Induced by Oxidative or Anoxic Storage of Red Wines
DOI: 10.1021/acs.jafc.0c04118

High-Fat Proteins Drive Dynamic Changes in Gut Microbiota, Hepatic Metabolome, and Endotoxemia-TLR-4-NFB-Mediated Inflammation in Mice
DOI: 10.1021/acs.jafc.0c02570


Journal of Chemical & Engineering Data
***

Derivative Properties Data for Hydrogen–Ethylene Supercritical Mixtures Using a SAFT EoS and a SAFT Force Field
Open Access Through ACS Author Choice
DOI: 10.1021/acs.jced.0c00699

Screening of Ionic Liquids and Deep Eutectic Solvents for Physical CO2 Absorption by Soft-SAFT Using Key Performance Indicators
Open Access Through ACS Author Choice
DOI: 10.1021/acs.jced.0c00750

SAFT-Based Maxwell–Stefan Approach to Model the Diffusion through Epoxy Resins
Open Access Through ACS Author Choice
DOI: 10.1021/acs.jced.0c00668

Solvatochromic Measurement of KAT Parameters and Modeling Preferential Solvation in Green Potential Binary Mixtures of N-Formylmorpholine with Water, Alcohols, and Ethyl Acetate
DOI: 10.1021/acs.jced.0c00589

Viscosity of Choline Chloride-Based Deep Eutectic Solvents: Experiments and Modeling
DOI: 10.1021/acs.jced.0c00715


Journal of Chemical Education
***

Let Us Teach Proper Thin Layer Chromatography Technique!
DOI: 10.1021/acs.jchemed.0c00437

What Role Should Chemistry Education Play in Addressing Societal Trust of Applications of Chemistry?
DOI: 10.1021/acs.jchemed.0c01228

Demonstrating Purple Color Development to Students by Showing the Highly Visual Effects of Aluminum Ions and pH on Aqueous Anthocyanin Solutions
DOI: 10.1021/acs.jchemed.0c00476

Effect of Temperature in Experiments Involving Carbonated Beverages
DOI: 10.1021/acs.jchemed.0c00844

Undergraduate Students’ Understanding of Surface Tension Considering Molecular Area
DOI: 10.1021/acs.jchemed.0c00447


Journal of Chemical Information and Modeling
***

Enumerating Intramolecular Charge Transfer in Conjugated Organic Compounds
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jcim.0c00913

Molecular Dynamics Reveals a DNA-Induced Dynamic Switch Triggering Activation of CRISPR-Cas12a
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jcim.0c00929

ZINC20—A Free Ultralarge-Scale Chemical Database for Ligand Discovery
Open Access Through ACS Author Choice
DOI: 10.1021/acs.jcim.0c00675

Identification of Noncompetitive Protein–Ligand Interactions for Structural Optimization
DOI: 10.1021/acs.jcim.0c00858

PubChemQC PM6: Data Sets of 221 Million Molecules with Optimized Molecular Geometries and Electronic Properties
DOI: 10.1021/acs.jcim.0c00740


Journal of Chemical Theory and Computation
***

A GPU-Accelerated Fast Multipole Method for GROMACS: Performance and Accuracy
Open Access Through ACS Author Choice
DOI: 10.1021/acs.jctc.0c00744

Explicit Representation of Cation Interactions in Force Fields with 1/r4 Nonbonded Terms
DOI: 10.1021/acs.jctc.0c00847

An Information-Theory-Based Approach for Optimal Model Reduction of Biomolecules
Open Access Through ACS Author Choice
DOI: 10.1021/acs.jctc.0c00676

Variational Density Functional Calculations of Excited States via Direct Optimization
DOI: 10.1021/acs.jctc.0c00597

CHARMM-GUI Free Energy Calculator for Absolute and Relative Ligand Solvation and Binding Free Energy Simulations
DOI: 10.1021/acs.jctc.0c00884


Journal of Medicinal Chemistry
***

Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1)
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jmedchem.0c00978

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19
DOI: 10.1021/acs.jmedchem.0c01063

Writing Your Next Medicinal Chemistry Article: Journal Bibliometrics and Guiding Principles for Industrial Authors
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jmedchem.0c01159

Understanding the Metabolism of Proteolysis Targeting Chimeras (PROTACs): The Next Step toward Pharmaceutical Applications
DOI: 10.1021/acs.jmedchem.0c00793

N-Trifluoromethyl Amines and Azoles: An Underexplored Functional Group in the Medicinal Chemist’s Toolbox
DOI: 10.1021/acs.jmedchem.0c01457


Journal of Natural Products
***

A Novel Class of Defensive Compounds in Harvestmen: Hydroxy-γ-Lactones from the Phalangiid Egaenus convexus
Open Access Through ACS Author Choice
DOI: 10.1021/acs.jnatprod.0c00277

Discovery of a Beetroot Protease Inhibitor to Identify and Classify Plant-Derived Cystine Knot Peptides
Open Access Through ACS Author Choice
DOI: 10.1021/acs.jnatprod.0c00648

Cytotoxic Germacranolides from the Whole Plant of Carpesium minus
DOI: 10.1021/acs.jnatprod.0c00428

Highly Oxygenated Caryophyllene-Type Sesquiterpenes from a Plant-Associated Fungus, Pestalotiopsis hainanensis, and Their Biosynthetic Gene Cluster
DOI: 10.1021/acs.jnatprod.0c00501

Synthetic Biology of Cannabinoids and Cannabinoid Glucosides in Nicotiana benthamiana and Saccharomyces cerevisiae
DOI: 10.1021/acs.jnatprod.0c00241


Journal of Proteome Research
***

The HUPO High-Stringency Inventory of Humanity’s Shared Human Proteome Revealed
DOI: 10.1021/acs.jproteome.0c00794

Utility of Proteomics in Emerging and Re-Emerging Infectious Diseases Caused by RNA Viruses
Open Access Through ACS Author Choice
DOI: 10.1021/acs.jproteome.0c00380

Proteomic Profiling of the Human Tissue and Biological Fluid Proteome
DOI: 10.1021/acs.jproteome.0c00502

Molecular Simulations and Network Modeling Reveal an Allosteric Signaling in the SARS-CoV-2 Spike Proteins
DOI: 10.1021/acs.jproteome.0c00654

Ultrahigh-Resolution Mass Spectrometry-Based Platform for Plasma Metabolomics Applied to Type 2 Diabetes Research
DOI: 10.1021/acs.jproteome.0c00510


Journal of the American Chemical Society
***

Total Synthesis of (-)-Mitrephorone A Enabled by Stereoselective Nitrile Oxide Cycloaddition and Tetrasubstituted Olefin Synthesis
Open Access Through ACS Author Choice
DOI: 10.1021/jacs.0c09520

Photoredox-Catalyzed Deaminative Alkylation via C–N Bond Activation of Primary Amines
DOI: 10.1021/jacs.0c08595

Phosphine-Catalyzed Intermolecular Acylfluorination of Alkynes via a P(V) Intermediate
DOI: 10.1021/jacs.0c08928

Cu-Catalyzed Enantioselective Alkylarylation of Vinylarenes Enabled by Chiral Binaphthyl–BOX Hybrid Ligands
DOI: 10.1021/jacs.0c09008

Ruthenium-Catalyzed trans-Hydroalkynylation and trans-Chloroalkynylation of Internal Alkynes
Open Access Through ACS Author Choice
DOI: 10.1021/jacs.0c08582


Journal of the American Society for Mass Spectrometry
***

USB-Powered Coated Blade Spray Ion Source for On-Site Testing Using Transportable Mass Spectrometry
Open Access Through ACS Author Choice
DOI: 10.1021/jasms.0c00307

Dynamics of Molecules Observed at Crude-Oil–Gas Interfaces by Time-of-Flight Secondary Ion Mass Spectrometry Imaging
Open Access Through ACS Author Choice
DOI: 10.1021/jasms.0c00290

Accelerating Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry Imaging Using a Subspace Approach
DOI: 10.1021/jasms.0c00276

Phenotype Classification using Proteome Data in a Data-Independent Acquisition Tensor Format
DOI: 10.1021/jasms.0c00254

Spatial Distribution of Endogenous Molecules in Coffee Beans by Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
DOI: 10.1021/jasms.0c00202


Langmuir
***

Mucin Biopolymers and Their Barrier Function at Airway Surfaces
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.langmuir.0c02410

Superior Anchoring of Sodium Polysulfides to the Polar C2N 2D Material: A Potential Electrode Enhancer in Sodium–Sulfur Batteries
Open Access Through ACS Author Choice
DOI: 10.1021/acs.langmuir.0c02616

Polycation–Anionic Lipid Membrane Interactions
Open Access Through ACS Author Choice
DOI: 10.1021/acs.langmuir.0c01062

Physicochemical and Biological Characterization of Novel Membrane-Active Cationic Lipopeptides with Antimicrobial Properties
Open Access Through ACS Author Choice
DOI: 10.1021/acs.langmuir.0c02135

Do Internal and External Surfaces of Metal–Organic Frameworks Have the Same Hydrophobicity? Insights from Molecular Simulations
DOI: 10.1021/acs.langmuir.0c02527


Macromolecules
***

A Comprehensive Platform for the Design and Synthesis of Polymer Molecular Weight Distributions
DOI: 10.1021/acs.macromol.0c01954

Harnessing Noncovalent Interactions to Drive Single-Chain Nanoparticle Formation
DOI: 10.1021/acs.macromol.0c01747

Synthesis and Aqueous Self-Assembly of ABCD Bottlebrush Block Copolymers
DOI: 10.1021/acs.macromol.0c01785

Two Polymersome Evolution Pathways in One Polymerization-Induced Self-Assembly (PISA) System
DOI: 10.1021/acs.macromol.0c01624

Gas Transport in a Polymer of Intrinsic Microporosity (PIM-1) Substituted with Pseudo-Ionic Liquid Tetrazole-Type Structures
Open Access Through ACS Author Choice
DOI: 10.1021/acs.macromol.0c01321


Molecular Pharmaceutics
***

Perspectives on Nanodelivery to the Brain: Prerequisites for Successful Brain Treatment
Open Access Through ACS Author Choice
DOI: 10.1021/acs.molpharmaceut.0c00881

Evaluating 225Ac and 177Lu Radioimmunoconjugates against Antibody–Drug Conjugates for Small-Cell Lung Cancer
DOI: 10.1021/acs.molpharmaceut.0c00703

SB431542-Loaded Liposomes Alleviate Liver Fibrosis by Suppressing TGF- Signaling
DOI: 10.1021/acs.molpharmaceut.0c00633

In Vitro and In Vivo Comparison of Curcumin-Encapsulated Chitosan-Coated Poly(lactic-co-glycolic acid) Nanoparticles and Curcumin/Hydroxypropyl-β-Cyclodextrin Inclusion Complexes Administered Intranasally as Therapeutic Strategies for Alzheimer’s Disease
DOI: 10.1021/acs.molpharmaceut.0c00675

pH-Sensitive Nanoparticles Codelivering Docetaxel and Dihydroartemisinin Effectively Treat Breast Cancer by Enhancing Reactive Oxidative Species-Mediated Mitochondrial Apoptosis
DOI: 10.1021/acs.molpharmaceut.0c00432


Nano Letters
***

Thermomechanical Nanostraining of Two-Dimensional Materials
Open Access Through ACS Author Choice
DOI: 10.1021/acs.nanolett.0c03358

Two-Tier Compatibility of Superelastic Bicrystal Micropillar at Grain Boundary
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.nanolett.0c03486

Nanoenabled Intracellular Calcium Bursting for Safe and Efficient Reversal of Drug Resistance in Tumor Cells
DOI: 10.1021/acs.nanolett.0c03042

Folding a Single-Molecule Junction
Open Access Through ACS Author Choice
DOI: 10.1021/acs.nanolett.0c02815

Self-Amplification of Tumor Oxidative Stress with Degradable Metallic Complexes for Synergistic Cascade Tumor Therapy
DOI: 10.1021/acs.nanolett.0c03127


Organic Letters
***

Cyanoamidine Cyclization Approach to Remdesivir’s Nucleobase
Open Access Through ACS Author Choice
DOI: 10.1021/acs.orglett.0c03052

Reflections on Organic Chemistry in China
DOI: 10.1021/acs.orglett.0c03299

Palladium-Catalyzed Hydroxylation of Aryl Halides with Boric Acid
DOI: 10.1021/acs.orglett.0c03069

Total Synthesis of (±)-Leonuketal
DOI: 10.1021/acs.orglett.0c03364

Triphenylphosphine-Catalyzed Alkylative Iododecarboxylation with Lithium Iodide under Visible Light
DOI: 10.1021/acs.orglett.0c03173


Organic Process Research & Development
***

Process Safety in the Pharmaceutical Industry—Part I: Thermal and Reaction Hazard Evaluation Processes and Techniques
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.oprd.0c00226

Some Items of Interest to Process R&D Chemists and Engineers
DOI: 10.1021/acs.oprd.0c00419

Optimization and Scale-Up of the Continuous Flow Acetylation and Nitration of 4-Fluoro-2-methoxyaniline to Prepare a Key Building Block of Osimertinib
Open Access through ACS Author Choice
DOI: 10.1021/acs.oprd.0c00254

Solubility Behaviors and Correlations of Common Solvent–Antisolvent Systems
DOI: 10.1021/acs.oprd.0c00387

Process Development of Sotagliflozin, a Dual Inhibitor of Sodium–Glucose Cotransporter-1/2 for the Treatment of Diabetes
DOI: 10.1021/acs.oprd.0c00359


Organometallics
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Catalytic C(sp2)–H Amination Reactions Using Dinickel Imides
DOI: 10.1021/acs.organomet.0c00504

Fluorescent Lewis Adducts: A Practical Guide to Relative Lewis Acidity
DOI: 10.1021/acs.organomet.0c00389

A Proton-Responsive Annulated Mesoionic Carbene (MIC) Scaffold on Ir Complex for Proton/Hydride Shuttle: An Experimental and Computational Investigation on Reductive Amination of Aldehyde
DOI: 10.1021/acs.organomet.0c00568

Silane Activation with Cobalt on the POCOP Pincer Ligand Platform
DOI: 10.1021/acs.organomet.0c00553

Accessing Pentagonal Bipyramidal Geometry with Pentadentate Pincer Amido-bis(amidate) Ligands in Group IV and V Early Transition Metal Complexes
DOI: 10.1021/acs.organomet.0c00501


The Journal of Organic Chemistry
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Time Economy in Total Synthesis
DOI: 10.1021/acs.joc.0c01581

Nucleophilic Transformations of Lewis Acid-Activated Disubstituted Epoxides with Catalyst-Controlled Regioselectivity
DOI: 10.1021/acs.joc.0c01691

Azulene Functionalization by Iron-Mediated Addition to a Cyclohexadiene Scaffold
Open Access through ACS Author Choice
DOI: 10.1021/acs.joc.0c01412

SN2 versus E2 Competition of F– and PH2– Revisited
Open Access through ACS Author Choice
DOI: 10.1021/acs.joc.0c02112

Metal-Free Indole–Phenacyl Bromide Cyclization: A Regioselective Synthesis of 3,5-Diarylcarbazoles
DOI: 10.1021/acs.joc.0c01670


The Journal of Physical Chemistry A
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Tuning the Binding Strength of Even and Uneven Hydrogen-Bonded Arrays with Remote Substituents
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpca.0c07815

Viewpoints on the 2020 Virtual Conference on Theoretical Chemistry
DOI: 10.1021/acs.jpca.0c08955

Not Completely Innocent: How Argon Binding Perturbs Cationic Copper Clusters
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpca.0c07771

Comprehensive Benchmark Results for the Accuracy of Basis Sets for Anharmonic Molecular Vibrations
DOI: 10.1021/acs.jpca.0c06634

Solving Chemistry Problems via an End-to-End Approach: A Proof of Concept
DOI: 10.1021/acs.jpca.0c06319


The Journal of Physical Chemistry B
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Tribute to Harold A. Scheraga
DOI: 10.1021/acs.jpcb.0c08867

Structural and Ion Dynamics in Fluorine-Free Oligoether Carboxylate Ionic Liquid-Based Electrolytes
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.0c04749

The Dynamism of Intrinsically Disordered Proteins: Binding-Induced Folding, Amyloid Formation, and Phase Separation
DOI: 10.1021/acs.jpcb.0c07598

Antiviral Peptides as Promising Therapeutics against SARS-CoV-2
DOI: 10.1021/acs.jpcb.0c05621

Refining All-Atom Protein Force Fields for Polar-Rich, Prion-like, Low-Complexity Intrinsically Disordered Proteins
DOI: 10.1021/acs.jpcb.0c07545


The Journal of Physical Chemistry C
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Optimizing the Key Variables to Generate Host Sensitized Lanthanide Doped Semiconductor Nanoparticle Luminophores
Open Access through ACS Editors’ Choice
DOI: 10.1021/acs.jpcc.0c07548

Effects of Framework Flexibility on the Adsorption and Diffusion of Aromatics in MFI-Type Zeolites
Open Access through ACS Author Choice
DOI: 10.1021/acs.jpcc.0c08054

Host–Guest Interactions in Metal–Organic Frameworks Doped with Acceptor Molecules as Revealed by Resonance Raman Spectroscopy
Open Access through ACS Author Choice
DOI: 10.1021/acs.jpcc.0c07473

Dynamics of Pd Dopant Atoms inside Au Nanoclusters during Catalytic CO Oxidation
Open Access through ACS Author Choice
DOI: 10.1021/acs.jpcc.0c05735

Soft Selection Rules for Femtosecond Pump–Probe Vibrational Coherence Spectroscopy
Open Access through ACS Author Choice
DOI: 10.1021/acs.jpcc.0c06504


The Journal of Physical Chemistry Letters
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Thermodynamics of the Interaction between the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus-2 and the Receptor of Human Angiotensin-Converting Enzyme 2. Effects of Possible Ligands
DOI: 10.1021/acs.jpclett.0c02203

The Ground State Electronic Energy of Benzene
DOI: 10.1021/acs.jpclett.0c02621

A Switch between Two Intrinsically Disordered Conformational Ensembles Modulates the Active Site of a Basic-Helix–Loop–Helix Transcription Factor
Open Access through ACS Author Choice
DOI: 10.1021/acs.jpclett.0c02242

Suppressing Auger Recombination in Cesium Lead Bromide Perovskite Nanocrystal Film for Bright Light-Emitting Diodes
DOI: 10.1021/acs.jpclett.0c02777

Resolving the Controversy over Dipole versus Quadrupole Mechanism of Bend Vibration of Water in Vibrational Sum Frequency Generation Spectra
DOI: 10.1021/acs.jpclett.0c02644