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Discover the Most-Read Chemistry Articles of January 20201

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles from each ACS Publications journal in January 2021, including traditional articles, reviews, perspectives, and editorial pieces. These lists were not chosen by the journals’ editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Click on your favorite journal below to see their most-read articles of the month.

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Accounts of Chemical Research

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Ideality in Context: Motivations for Total Synthesis
DOI: 10.1021/acs.accounts.0c00821

Navigating the Unnatural Reaction Space: Directed Evolution of Heme Proteins for Selective Carbene and Nitrene Transfer
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.accounts.0c00591

Metamorphoses of Cesium Lead Halide Nanocrystals
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.accounts.0c00710

Lessons from Natural Product Total Synthesis: Macrocyclization and Postcyclization Strategies
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.accounts.0c00759

Giant Rylene Imide-Based Electron Acceptors for Organic Photovoltaics
DOI: 10.1021/acs.accounts.0c00677


Accounts of Materials Research

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Two-Dimensional-Material Membranes: Manipulating the Transport Pathway for Molecular Separation
DOI: 10.1021/accountsmr.0c00092

Refining Grains of Metals through Plastic Deformation: Toward Grain Size Limits
DOI: 10.1021/accountsmr.0c00075

Imaging Excited-State Dynamics in Two-Dimensional Semiconductors with Emerging Ultrafast Measurement Techniques
DOI: 10.1021/accountsmr.0c00064

Graphene Oxide Assemblies for Sustainable Clean-Water Harvesting and Green-Electricity Generation
DOI: 10.1021/accountsmr.0c00073

Implantable Fiber Biosensors Based on Carbon Nanotubes
DOI: 10.1021/accountsmr.0c00109


ACS Agricultural Science & Technology

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Nickel Influences Urease Activity and Calcium Distribution in Tomato Fruits
DOI: 10.1021/acsagscitech.0c00003

Will the Chemical Contaminants in Agricultural Soil Affect the Ecotoxicity of Microplastics?
DOI: 10.1021/acsagscitech.0c00005

One-Step Design of a Water-Resistant Green-to-Red Phosphor for Horticultural Sunlight Conversion
DOI: 10.1021/acsagscitech.0c00062

Identification of Metabolites in Basil Leaves by Desorption Electrospray Ionization Mass Spectrometry Imaging after Cd Contamination
DOI: 10.1021/acsagscitech.0c00038

Greenhouse Gas Emissions and Global Warming Potential from a Woody Ornamental Production System Using a Soilless Growing Substrate
DOI: 10.1021/acsagscitech.0c00039


ACS Applied Bio Materials

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Osteogenic Potential of Additively Manufactured TiTa Alloys
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsabm.0c01450

Advances in Facemasks during the COVID-19 Pandemic Era
DOI: 10.1021/acsabm.0c01329

Nature Inspired Multienzyme Immobilization: Strategies and Concepts
DOI: 10.1021/acsabm.0c01293

High-Throughput Automation of Endosomolytic Polymers for mRNA Delivery
DOI: 10.1021/acsabm.0c01463

Recent Progress in Photocatalytic Antibacterial
DOI: 10.1021/acsabm.0c01335


ACS Applied Electronic Materials

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Mott Switching and Structural Transition in the Metal Phase of VO2 Nanodomain
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsaelm.0c00983

Direct Epitaxial Approach to Achieve a Monolithic On-Chip Integration of a HEMT and a Single Micro-LED with a High-Modulation Bandwidth
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsaelm.0c00985

Large Remnant Polarization in a Wake-Up Free Hf0.5Zr0.5O2 Ferroelectric Film through Bulk and Interface Engineering
DOI: 10.1021/acsaelm.0c00671

High-Temperature Annealed Biochar as a Conductive Filler for the Production of Piezoresistive Materials for Energy Conversion Application
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsaelm.0c00971

Recent Advances on Spin-Polarized Two-Dimensional Electron Gases at Oxide Interfaces
DOI: 10.1021/acsaelm.0c00860


ACS Applied Energy Materials

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Outstanding Thermoelectric Performance of MCu3X4 (M = V, Nb, Ta; X = S, Se, Te) with Unaffected Band Degeneracy under Pressure
DOI: 10.1021/acsaem.0c03043

Tuning the Nanoporous Structure of Carbons Derived from the Composite of Cross-Linked Polymers for Charge Storage Applications
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsaem.0c02908

In Situ Diffusion Measurements of a NASICON-Structured All-Solid-State Battery Using Muon Spin Relaxation
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsaem.0c02722

Impedance Analysis of NCM Cathode Materials: Electronic and Ionic Partial Conductivities and the Influence of Microstructure
DOI: 10.1021/acsaem.0c02606

SnOx Atomic Layer Deposition on Bare Perovskite—An Investigation of Initial Growth Dynamics, Interface Chemistry, and Solar Cell Performance
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsaem.0c02405


ACS Applied Materials & Interfaces

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Biomimetic Soft Polymer Microstructures and Piezoresistive Graphene MEMS Sensors Using Sacrificial Metal 3D Printing
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsami.0c21295

Development of an Ultrastretchable Double-Network Hydrogel for Flexible Strain Sensors
DOI: 10.1021/acsami.0c19104

Multimaterial Printing for Cephalopod-Inspired Light-Responsive Artificial Chromatophores
DOI: 10.1021/acsami.0c17623

4D Biofabrication Using a Combination of 3D Printing and Melt-Electrowriting of Shape-Morphing Polymers
DOI: 10.1021/acsami.0c18608

Heavy-Atom-Free Room-Temperature Phosphorescent Organic Light-Emitting Diodes Enabled by Excited States Engineering
DOI: 10.1021/acsami.0c17295


ACS Applied Nano Materials

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In Situ Study of the Wet Chemical Etching of SiO2 and Nanoparticle@SiO2 Core–Shell Nanospheres
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsanm.0c02771

Highly Soluble CsPbBr3 Perovskite Quantum Dots for Solution-Processed Light-Emission Devices
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsanm.0c02797

Experimental Mid-Infrared Absorption (84%) of Single-Layer Graphene in a Reflective Asymmetric Fabry–Perot Filter: Implications for Photodetectors
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsanm.0c03010

Conformal Growth of Nanometer-Thick Transition Metal Dichalcogenide TiSx-NbSx Heterostructures over 3D Substrates by Atomic Layer Deposition: Implications for Device Fabrication over 3D Substrates by Atomic Layer Deposition: Implications for Device Fabrication
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsanm.0c02820

Copper-Based Superhydrophobic Nanostructures for Heat Transfer in Flow Condensation
DOI: 10.1021/acsanm.0c03181


ACS Applied Polymer Materials

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Three-Dimensional Fine Structure of Nanometer-Scale Nafion Thin Films
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsapm.0c01318

High Thermal Conductivity in Anisotropic Aligned Polymeric Materials
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsapm.0c01340

Forum: High Efficiency Polymers for Solar Cell Applications
This article is part of the High Efficiency Polymers for Solar Cell Applications special issue.
DOI: 10.1021/acsapm.0c01361

Hierarchical Porous Polymers via a Microgel Intermediate: Green Synthesis and Applications toward the Removal of Pollutants
DOI: 10.1021/acsapm.0c01086

Self-Healable Polyurethane Elastomer Based on Dual Dynamic Covalent Chemistry Using Diels–Alder “Click” and Disulfide Metathesis Reactions
DOI: 10.1021/acsapm.0c01179


ACS Biomaterials Science & Engineering

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Prolonged Codelivery of Hemagglutinin and a TLR7/8 Agonist in a Supramolecular Polymer–Nanoparticle Hydrogel Enhances Potency and Breadth of Influenza Vaccination
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsbiomaterials.0c01496

Structural Evaluation of the Choline and Geranic Acid/Water Complex by SAXS and NMR Analyses
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsbiomaterials.0c01324

Native-like Flow Properties of an Artificial Spider Silk Dope
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsbiomaterials.0c01308

Methoxy-Functionalized Glycerol-Based Aliphatic Polycarbonate: Organocatalytic Synthesis, Blood Compatibility, and Hydrolytic Property
DOI: 10.1021/acsbiomaterials.0c01460

Liquid CO2 Formulated Mesoporous Silica Nanoparticles for pH-Responsive Oral Delivery of Meropenem
DOI: 10.1021/acsbiomaterials.0c01284


ACS Catalysis

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Direct Arylation of Simple Arenes with Aryl Bromides by Synergistic Silver and Palladium Catalysis
DOI: 10.1021/acscatal.0c05254

Single Electron Transfer-Induced Redox Processes Involving N-(Acyloxy)phthalimides
DOI: 10.1021/acscatal.0c04756

Carbonyl Desaturation: Where Does Catalysis Stand?
DOI: 10.1021/acscatal.0c04712

Insights into the Mechanism of Low-Valent Cobalt-Catalyzed C–H Activation
DOI: 10.1021/acscatal.0c04205

Visible-Light-Enhanced Cobalt-Catalyzed Hydrogenation: Switchable Catalysis Enabled by Divergence between Thermal and Photochemical Pathways
DOI: 10.1021/acscatal.0c05136


ACS Central Science

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A Single Immunization with Spike-Functionalized Ferritin Vaccines Elicits Neutralizing Antibody Responses against SARS-CoV-2 in Mice
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c01405

Specialized Metabolites Reveal Evolutionary History and Geographic Dispersion of a Multilateral Symbiosis
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c00978

Accurate Representations of the Microphysical Processes Occurring during the Transport of Exhaled Aerosols and Droplets
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c01522

You Wouldn’t Download a Molecule! Now, ChemSCAD Makes It Possible
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.1c00108

Automatic Generation of 3D-Printed Reactionware for Chemical Synthesis Digitization using ChemSCAD
Open Access Through ACS AuthorChoice
DOI: 10.1021/acscentsci.0c01354


ACS Chemical Biology

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m6A-RNA Demethylase FTO Inhibitors Impair Self-Renewal in Glioblastoma Stem Cells
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschembio.0c00841

Triangular in Vivo Self-Assembling Coiled-Coil Protein Origami
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschembio.0c00812

Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschembio.0c00864

Discovery of 4,4′-Dipyridylsulfide Analogs as “Switchable Electrophiles” for Covalent Inhibition
DOI: 10.1021/acschembio.0c00890

Chemical Diversification of Simple Synthetic Antibodies
DOI: 10.1021/acschembio.0c00865


ACS Chemical Health & Safety

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Fall 2020 Proceedings of the Cannabis Chemistry Subdivision
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.chas.0c00119

A Transferable Psychological Evaluation of Virtual Reality Applied to Safety Training in Chemical Manufacturing
DOI: 10.1021/acs.chas.0c00105

Working the Accident: Staying Alive at Chemical Disaster Sites
DOI: 10.1021/acs.chas.0c00113

Lessons Learned—Fluoride Exposure and Response
DOI: 10.1021/acs.chas.0c00108

Highlights: Safety Blogs, Alane Reduction, Postlockdown Process Safety Concerns, and More
DOI: 10.1021/acs.chas.0c00124


ACS Chemical Neuroscience

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Occurrence of Morpholine in Central Nervous System Drug Discovery
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschemneuro.0c00729

Inhibition of Amyloid β-Induced Lipid Membrane Permeation and Amyloid β Aggregation by K162
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschemneuro.0c00754

Multitarget Biological Profiling of New Naphthoquinone and Anthraquinone-Based Derivatives for the Treatment of Alzheimer’s Disease
Open Access Through ACS AuthorChoice
DOI: 10.1021/acschemneuro.0c00624

Programmable DNA Nanodevices for Applications in Neuroscience
DOI: 10.1021/acschemneuro.0c00723

Psychedelic-like Properties of Quipazine and Its Structural Analogues in Mice
DOI: 10.1021/acschemneuro.0c00291


ACS Earth and Space Chemistry

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Humidity-Dependent Viscosity of Secondary Organic Aerosol from Ozonolysis of β-Caryophyllene: Measurements, Predictions, and Implications
DOI: 10.1021/acsearthspacechem.0c00296

Origin of Deep Methane Associated with a Unique Community of Microorganisms in an Organic- and Iodine-Rich Aquifer
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsearthspacechem.0c00204

Wintertime Air Quality in Lumbini, Nepal: Sources of Fine Particle Organic Carbon
DOI: 10.1021/acsearthspacechem.0c00269

Evidence for Strong HONO Emission from Fertilized Agricultural Fields and its Remarkable Impact on Regional O3 Pollution in the Summer North China Plain
DOI: 10.1021/acsearthspacechem.0c00314

Evolution of the Dissolved Organic Matter Composition along the Upper Mekong (Lancang) River
DOI: 10.1021/acsearthspacechem.0c00292


ACS Energy Letters

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Why Seeing Is Not Always Believing: Common Pitfalls in Photocatalysis and Electrocatalysis
DOI: 10.1021/acsenergylett.1c00064

Enhanced Performance and Stability of 3D/2D Tin Perovskite Solar Cells Fabricated with a Sequential Solution Deposition
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsenergylett.0c02305

The Complicated Morality of Named Inventions
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsenergylett.0c02657

Opportunities and Challenges of Lithium Ion Batteries in Automotive Applications
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsenergylett.0c02584

Atomically Dispersed Fe–Heteroatom (N, S) Bridge Sites Anchored on Carbon Nanosheets for Promoting Oxygen Reduction Reaction
DOI: 10.1021/acsenergylett.0c02484


ACS ES&T Water

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Welcome to ACS ES&T Water: Vision and Inspiration
DOI: 10.1021/acsestwater.0c00298

Application of a Multiobjective Artificial Neural Network (ANN) in Industrial Reverse Osmosis Concentrate Treatment with a Fluidized Bed Fenton Process: Performance Prediction and Process Optimization
DOI: 10.1021/acsestwater.0c00192

Assessment of Highly Polar Chemicals in Dutch and Flemish Drinking Water and Its Sources: Presence and Potential Risks
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsestwater.0c00237

Application of Quantitative Structure–Property Relationship Predictive Models to Water Treatment: A Critical Review
DOI: 10.1021/acsestwater.0c00206

Effect of Phenolic Organics on the Precipitation of Struvite from Simulated Dairy Wastewater
DOI: 10.1021/acsestwater.0c00234


ACS ES&T Engineering

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Effect of Process Variables on Food Waste Valorization via Hydrothermal Liquefaction
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsestengg.0c00115

Energy Consumption of Brackish Water Desalination: Identifying the Sweet Spots for Electrodialysis and Reverse Osmosis
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsestengg.0c00192

Review of Advances in Engineering Nanomaterial Adsorbents for Metal Removal and Recovery from Water: Synthesis and Microstructure Impacts
DOI: 10.1021/acsestengg.0c00174

Polyamide Nanofiltration Membranes from Emulsion-Mediated Interfacial Polymerization
DOI: 10.1021/acsestengg.0c00213

Bidirectional Progressive Optimization of Carbon and Nitrogen Defects in Solar-Driven Regenerable Adsorbent to Remove UV-Filters from Water
DOI: 10.1021/acsestengg.0c00176


ACS Food Science & Technology

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Microwave-Assisted Extraction as a Green Technology Approach to Recover Polyphenols from Castanea sativa Shells
DOI: 10.1021/acsfoodscitech.0c00055

Evaluating the Effectiveness of Lactobacillus zeae against Enterotoxigenic Escherichia coli F4 Infection in an In Vitro Porcine Intestinal Epithelial Cell Model
DOI: 10.1021/acsfoodscitech.0c00069

Fabrication of Soy Protein Nanoparticles via Partial Enzymatic Hydrolysis and Their Role in Controlling Lipid Digestion of Oil-in-Water Emulsions
DOI: 10.1021/acsfoodscitech.0c00005

Untargeted Metabolomics Reveals Metabolic Changes Linked to Bulb Purpling in Garlic (Allium sativum L.)
DOI: 10.1021/acsfoodscitech.0c00106

Secretion of Bacillus amyloliquefaciens Levansucrase from Bacillus subtilis and Its Application in the Enzymatic Synthesis of Levan
DOI: 10.1021/acsfoodscitech.0c00044


ACS Infectious Diseases

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Proteolytic Activation of SARS-CoV-2 Spike at the S1/S2 Boundary: Potential Role of Proteases beyond Furin
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsinfecdis.0c00701

Early Returns on Small Molecule Therapeutics for SARS-CoV-2
DOI: 10.1021/acsinfecdis.0c00874

Combining Colistin and Fluconazole Synergistically Increases Fungal Membrane Permeability and Antifungal Cidality
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.0c00721

Structure–Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.0c00851

A Machine Learning Strategy for Drug Discovery Identifies Anti-Schistosomal Small Molecules
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsinfecdis.0c00754


ACS Macro Letters

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Engineering Segregated Structures in a Cross-Linked Elastomeric Network Enabled by Dynamic Cross-Link Reshuffling
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acsmacrolett.0c00852

Reflection on the Matyjaszewski Lab Webinar Series and the Rise of Webinars in Polymer Chemistry
DOI: 10.1021/acsmacrolett.0c00806

100th Anniversary of Macromolecular Science Viewpoint: Attractive Soft Matter: Association Kinetics, Dynamics, and Pathway Complexity in Electrostatically Coassembled Micelles
Open Access Through ACS AuthorChoice
DOI: 10.1021/acsmacrolett.0c00787

Geared Toward Applications: A Perspective on Functional Sequence-Controlled Polymers
DOI: 10.1021/acsmacrolett.0c00855

Cascade Ring-Opening/Ring-Closing Metathesis Polymerization of a Monomer Containing a Norbornene and a Cyclohexene Ring
DOI: 10.1021/acsmacrolett.0c00882


ACS Materials Letters

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ACS Materials Letters at 1.5 Years
DOI: 10.1021/acsmaterialslett.0c00579

Perspective on High-Rate Alkaline Water Splitting
DOI: 10.1021/acsmaterialslett.0c00536

Emerging Materials for Water-Enabled Electricity Generation
DOI: 10.1021/acsmaterialslett.0c00474

One-Pot Confined Epitaxial Growth of 2D Heterostructure Arrays
DOI: 10.1021/acsmaterialslett.0c00517

Nacre-Inspired Sustainable Coatings with Remarkable Fire-Retardant and Energy-Saving Cooling Performance
DOI: 10.1021/acsmaterialslett.0c00509


ACS Medicinal Chemistry Letters

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Steering New Drug Discovery Campaigns: Permeability, Solubility, and Physicochemical Properties in the bRo5 Chemical Space
DOI: 10.1021/acsmedchemlett.0c00581

Derivatization Design of Synthetically Accessible Space for Optimization: In Silico Synthesis vs Deep Generative Design
DOI: 10.1021/acsmedchemlett.0c00540

Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead
DOI: 10.1021/acsmedchemlett.0c00612

Potential of Cyclin-Dependent Kinase Inhibitors as Cancer Therapy
DOI: 10.1021/acsmedchemlett.1c00017

Sigma-1 and Sigma-2 Receptor Modulators as Potential Therapeutics for Alzheimer’s Disease
DOI: 10.1021/acsmedchemlett.1c00002


ACS Nano

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Selection of Fluorescent, Bioluminescent, and Radioactive Tracers to Accurately Reflect Extracellular Vesicle Biodistribution in Vivo
Open Access through ACS AuthorChoice
DOI: 10.1021/acsnano.0c09873

Nanopore-Based Power Generation from Salinity Gradient: Why It Is Not Viable
Open Access through ACS AuthorChoice
DOI: 10.1021/acsnano.0c08628

Ti3C2Tx MXene-Activated Fast Gelation of Stretchable and Self-Healing Hydrogels: A Molecular Approach
DOI: 10.1021/acsnano.0c07998

Rapid Development of SARS-CoV-2 Spike Protein Receptor-Binding Domain Self-Assembled Nanoparticle Vaccine Candidates
Open Access through ACS AuthorChoice
DOI: 10.1021/acsnano.0c08379

Dopamine-Triggered Hydrogels with High Transparency, Self-Adhesion, and Thermoresponse as Skinlike Sensors
DOI: 10.1021/acsnano.0c09577


ACS Omega

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From Infection Clusters to Metal Clusters: Significance of the Lowest Occupied Molecular Orbital (LOMO)
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsomega.0c04913

Influence of the Substrate, Process Conditions, and Postannealing Temperature on the Properties of ZnO Thin Films Grown by the Successive Ionic Layer Adsorption and Reaction Method
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c04837

In Vivo Antinociceptive, Muscle Relaxant, Sedative, and Molecular Docking Studies of Peshawaraquinone Isolated from Fernandoa adenophylla (Wall. ex G. Don) Steenis
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c05720

In Situ Formation of Silver Nanoparticles (Ag-NPs) onto Textile Fibers
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c04814

Combined Colorimetric and Electrochemical Measurement Paper-Based Device for Chemometric Proof-of-Concept Analysis of Cocaine Samples
Open Access through ACS AuthorChoice
DOI: 10.1021/acsomega.0c05077


ACS Pharmacology & Translational Science

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Ethical Concerns about Psilocybin Intellectual Property
Open Access through ACS Editors’ Choice
DOI: 10.1021/acsptsci.0c00171

Spontaneous In Vitro and In Vivo Interaction of (−)-Oleocanthal with Glycine in Biological Fluids: Novel Pharmacokinetic Markers
DOI: 10.1021/acsptsci.0c00166

Single Cell Mass Spectrometry Quantification of Anticancer Drugs: Proof of Concept in Cancer Patients
DOI: 10.1021/acsptsci.0c00156

Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms
DOI: 10.1021/acsptsci.0c00196

Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor
DOI: 10.1021/acsptsci.0c00195


ACS Photonics

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Enhanced Nonlinear Emission from Single Multilayered Metal–Dielectric Nanocavities Resonating in the Near-Infrared
Open Access through ACS AuthorChoice
DOI: 10.1021/acsphotonics.0c01500

Nonlinear Optical Response of a WS2 Monolayer at Room Temperature upon Multicolor Laser Excitation
Open Access through ACS AuthorChoice
DOI: 10.1021/acsphotonics.0c01567

Quantum Nanophotonics in Two-Dimensional Materials
DOI: 10.1021/acsphotonics.0c01224

The Path to Enlightenment: Progress and Opportunities in High Efficiency Halide Perovskite Light-Emitting Devices
DOI: 10.1021/acsphotonics.0c01394

Deep Learning to Accelerate Scatterer-to-Field Mapping for Inverse Design of Dielectric Metasurfaces
DOI: 10.1021/acsphotonics.0c01468


ACS Sensors

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Flow-Through Quantification of Microplastics Using Impedance Spectroscopy
Open Access through ACS Editors’ Choice
DOI: 10.1021/acssensors.0c02223

InVivo Brain Imaging of Amyloid-β Aggregates in Alzheimer’s Disease with a Near-Infrared Fluorescent Probe
DOI: 10.1021/acssensors.0c01914

Ratiometric Bioluminescent Indicator for Simple and Rapid Diagnosis of Bilirubin
DOI: 10.1021/acssensors.0c02000

Fluorometric Paper-Based, Loop-Mediated Isothermal Amplification Devices for Quantitative Point-of-Care Detection of Methicillin-Resistant Staphylococcus aureus (MRSA)
DOI: 10.1021/acssensors.0c01405

Missing-Linker 2D Conductive Metal Organic Frameworks for Rapid Gas Detection
DOI: 10.1021/acssensors.0c01933


ACS Sustainable Chemistry & Engineering

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ACS Sustainable Chemistry & Engineering Welcomes Expanded Editorial Boards with New Initiatives
DOI: 10.1021/acssuschemeng.0c09172

The Mechanochemical Beckmann Rearrangement: An Eco-efficient “Cut-and-Paste” Strategy to Design the “Good Old Amide Bond”
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.0c07254

Lignin–Zein Composite: Synthesis, Three-Dimensional Printing, and Microbial Degradation
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.0c07915

Tandem Heterogeneous Catalysis for Polyethylene Depolymerization via an Olefin-Intermediate Process
DOI: 10.1021/acssuschemeng.0c07612

Sustainable Lactic Acid Production from Lignocellulosic Biomass
Open Access through ACS AuthorChoice
DOI: 10.1021/acssuschemeng.0c08055


ACS Symposium Series

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Caring for Your Brand…And Your Career
DOI: 10.1021/bk-2020-1366.ch001

Preface
DOI: 10.1021/bk-2020-1366.pr001

Career Success in the Chemical Profession–A “How to” Primer
DOI: 10.1021/bk-2020-1366.ch005

Editor’s Biography
DOI: 10.1021/bk-2020-1366.ot001

Becoming an Outstanding Professor
DOI: 10.1021/bk-2020-1366.ch006


ACS Synthetic Biology

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Mutation Maker, An Open Source Oligo Design Platform for Protein Engineering
Open Access through ACS AuthorChoice
DOI: 10.1021/acssynbio.0c00542

Cell-free Directed Evolution of a Protease in Microdroplets at Ultrahigh Throughput
Open Access through ACS AuthorChoice
DOI: 10.1021/acssynbio.0c00538

Prime Editing Guide RNA Design Automation Using PINE-CONE
Open Access through ACS AuthorChoice
DOI: 10.1021/acssynbio.0c00445

A Streptomyces venezuelae Cell-Free Toolkit for Synthetic Biology
Open Access through ACS AuthorChoice
DOI: 10.1021/acssynbio.0c00581

Allosteric Regulation of DNA Circuits Enables Minimal and Rapid Biosensors of Small Molecules
Open Access through ACS AuthorChoice
DOI: 10.1021/acssynbio.0c00545


Analytical Chemistry

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Zero- to Ultralow-Field NMR Spectroscopy of Small Biomolecules
DOI: 10.1021/acs.analchem.0c04738

Multiplexed CuAAC Suzuki–Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling
DOI: 10.1021/acs.analchem.0c04726

A Practical Guide to Metabolomics Software Development
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.analchem.0c03581

Suitcase Lab for Rapid Detection of SARS-CoV-2 Based on Recombinase Polymerase Amplification Assay
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.analchem.0c04779

How Can Chemometrics Support the Development of Point of Need Devices?
DOI: 10.1021/acs.analchem.0c04151


Biochemistry

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In vitro-Constructed Ribosomes Enable Multi-site Incorporation of Noncanonical Amino Acids into Proteins
DOI: 10.1021/acs.biochem.0c00829

Disulfide Bridging Strategies in Viral and Nonviral Platforms for Nucleic Acid Delivery
DOI: 10.1021/acs.biochem.0c00860

Dried Protein Structure Revealed at the Residue Level by Liquid-Observed Vapor Exchange NMR
DOI: 10.1021/acs.biochem.0c00863

Small Molecule-Induced Dimerization of Hairpin RNA Interfered with the Dicer Cleavage Reaction
DOI: 10.1021/acs.biochem.0c00920

Protein Mass-Modulated Effects in Alkaline Phosphatase
DOI: 10.1021/acs.biochem.0c00917


Bioconjugate Chemistry

***

Dual Site-Specific Chemoenzymatic Antibody Fragment Conjugation Using CRISPR-Based Hybridoma Engineering
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.bioconjchem.0c00673

Copper-Free Click Enabled Triazabutadiene for Bioorthogonal Protein Functionalization
DOI: 10.1021/acs.bioconjchem.0c00677

Multifunctional Neomycin-Triazine-Based Cationic Lipids for Gene Delivery with Antibacterial Properties
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.bioconjchem.0c00616

Design and Application of Receptor-Targeted Fluorescent Probes Based on Small Molecular Fluorescent Dyes
DOI: 10.1021/acs.bioconjchem.0c00606

Bioconjugate Supramolecular Pd2+ Metallacages Penetrate the Blood Brain Barrier In Vitro and In Vivo
DOI: 10.1021/acs.bioconjchem.0c00659


Biomacromolecules

***

Hydrogel-Based Bioinks for Cell Electrowriting of Well-Organized Living Structures with Micrometer-Scale Resolution
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.biomac.0c01577

Bioinspired Macromolecular Materials
This article is part of the Bioinspired Macromolecular Materials special issue.
DOI: 10.1021/acs.biomac.0c01614

Enzyme-Functionalized Cellulose Beads as a Promising Antimicrobial Material
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.biomac.0c01536

Judging Enzyme-Responsive Micelles by Their Covers: Direct Comparison of Dendritic Amphiphiles with Different Hydrophilic Blocks
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.biomac.0c01708

Polymeric Materials for Eye Surface and Intraocular Applications
DOI: 10.1021/acs.biomac.0c01525


C&EN Global Enterprise

***

A champion for chemistry
DOI: 10.1021/cen-09901-cover

2021 Cope and Cope Scholar Award winners
DOI: 10.1021/cen-09902-awards

2021 ACS National Award winners—Part I
DOI: 10.1021/cen-09901-awards1

2021 ACS National Award winners 4
DOI: 10.1021/cen-09901-awards4

C&EN’s World Chemical Outlook 2021
DOI: 10.1021/cen-09902-cover1


Chemical Research in Toxicology

***

LC–MS/MS Analysis of the Formation and Loss of DNA Adducts in Rats Exposed to Vinyl Acetate Monomer through Inhalation
DOI: 10.1021/acs.chemrestox.0c00404

In Silico Prediction of Input Parameters for Simplified Physiologically Based Pharmacokinetic Models for Estimating Plasma, Liver, and Kidney Exposures in Rats after Oral Doses of 246 Disparate Chemicals
DOI: 10.1021/acs.chemrestox.0c00336

Exposure Assessment of Toxicologically Relevant Volatile Organic Compounds Emitted from Polymer-Based Costume Masks
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.chemrestox.0c00414

Integrated QSAR and Adverse Outcome Pathway Analysis of Chemicals Released on 3D Printing Using Acrylonitrile Butadiene Styrene
DOI: 10.1021/acs.chemrestox.0c00274

A Chemical Link between Meat Consumption and Colorectal Cancer Development?
DOI: 10.1021/acs.chemrestox.0c00395


Chemical Reviews

***

Dynamic Covalent Polymer Networks: A Molecular Platform for Designing Functions beyond Chemical Recycling and Self-Healing
DOI: 10.1021/acs.chemrev.0c00938

A Hitchhiker’s Guide to Click-Chemistry with Nucleic Acids
Open Access through ACS AuthorChoice
This article is part of the Click Chemistry special issue.
DOI: 10.1021/acs.chemrev.0c00928

Mechanisms of Energy Transduction by Charge Translocating Membrane Proteins
DOI: 10.1021/acs.chemrev.0c00830

Chiroptical Properties of Symmetric Double, Triple, and Multiple Helicenes
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.chemrev.0c01017

The Use of Alternative Strategies for Enhanced Nanoparticle Delivery to Solid Tumors
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.chemrev.0c00779


Chemistry of Materials

***

Our Most Downloaded Papers Published in 2020
DOI: 10.1021/acs.chemmater.0c04607

Synthesis and Structure–Property Relationships of Polyimide Covalent Organic Frameworks for Carbon Dioxide Capture and (Aqueous) Sodium-Ion Batteries
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.chemmater.0c03218

Coordinating Solvent-Assisted Synthesis of Phase-Stable Perovskite Nanocrystals with High Yield Production for Optoelectronic Applications
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.chemmater.0c03463

In-Depth Characterization of Lithium-Metal Surfaces with XPS and ToF-SIMS: Toward Better Understanding of the Passivation Layer
DOI: 10.1021/acs.chemmater.0c03518

Insights into the Lithium Sub-structure of Superionic Conductors Li3YCl6 and Li3YBr6
DOI: 10.1021/acs.chemmater.0c04352


Crystal Growth & Design

***

Crystal Growth & Design in Lockdown
DOI: 10.1021/acs.cgd.0c01484

Development of Polycrystalline Diamond Compatible with the Latest N-Polar GaN mm-Wave Technology
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.cgd.0c01319

Solid-State Conformational Flexibility at Work: Energetic Landscape of a Single Crystal-to-Single Crystal Transformation in a Cyclic Hexapeptoid
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.cgd.0c01244

Isostructural Charge-Transfer Cocrystals Based on Triptycene End-Capped Quinoxalinophenanthrophenazine
DOI: 10.1021/acs.cgd.0c01619

Chemical Fixation of CO2 Under Solvent and Co-Catalyst-free Conditions Using a Highly Porous Two-fold Interpenetrated Cu(II)-Metal–Organic Framework
DOI: 10.1021/acs.cgd.0c01530


Energy & Fuels

***

High-Voltage “Single-Crystal” Cathode Materials for Lithium-Ion Batteries
DOI: 10.1021/acs.energyfuels.0c03608

The Role of Methyl Groups in the Early Stage of Thermal Polymerization of Polycyclic Aromatic Hydrocarbons Revealed by Molecular Imaging
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.energyfuels.0c04016

Structure and Laminar Flame Speed of an Ammonia/Methane/Air Premixed Flame under Varying Pressure and Equivalence Ratio
Open Access through ACS AuthorChoice
This article is part of the In Memory of Mario Costa special issue.
DOI: 10.1021/acs.energyfuels.0c03520

Ash Transformation during Single-Pellet Combustion of Agricultural Biomass with a Focus on Potassium and Phosphorus
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.energyfuels.0c03324

Virtual Special Issue of the 21st International Conference on Petroleum Phase Behavior and Fouling (PetroPhase2020)
DOI: 10.1021/acs.energyfuels.1c00206


Environmental Science & Technology

***

Welcome to the Future: Introducing ES&T’s Inaugural Early Career Editorial Advisory Board
DOI: 10.1021/acs.est.0c08384

The 2021 Outstanding Achievements in Environmental Science & Technology Award—The Asia-Pacific Region
DOI: 10.1021/acs.est.0c08638

Comment on “Five Misperceptions Surrounding the Environmental Impacts of Single-Use Plastic”
DOI: 10.1021/acs.est.0c07842

Climate Change Impacts of Electricity Generated at a Waste-to-Energy Facility
DOI: 10.1021/acs.est.0c03477

Development of a Performance Evaluation Protocol for Air Sensors Deployed on a Google Street View Car
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.est.0c05955


Environmental Science & Technology Letters

***

Cannabis and the Environment: What Science Tells Us and What We Still Need to Know
DOI: 10.1021/acs.estlett.0c00844

Community Transmission of SARS-CoV-2 by Surfaces: Risks and Risk Reduction Strategies
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.estlett.0c00966

The 2021 Outstanding Achievements in Environmental Science & Technology Award: The Asia–Pacific Region
DOI: 10.1021/acs.estlett.0c00996

Large Plastic Debris Dumps: New Biodiversity Hot Spots Emerging on the Deep-Sea Floor
DOI: 10.1021/acs.estlett.0c00967

Comment on “Scientific Basis for Managing PFAS as a Chemical Class”
DOI: 10.1021/acs.estlett.0c00765


Industrial & Engineering Chemistry Research

***

Role of Carbon Capture, Storage, and Utilization to Enable a Net-Zero-CO2-Emissions Aviation Sector
Open Access through ACS AuthorChoice
This article is part of the Enrico Tronconi Festschrift special issue.
DOI: 10.1021/acs.iecr.0c05392

Updating Industrial & Engineering Chemistry Research’s Journal Scope and Editorial Team Additions
DOI: 10.1021/acs.iecr.0c06256

Questionable Recyclable Catalyst: Comment on “O-Acetyl-Substituted Phenol Ester Synthesis via Direct Oxidative Esterification Utilizing Ethers as an Acylating Source with Cu2(dhtp) Metal–Organic Framework as a Recyclable Catalyst”
DOI: 10.1021/acs.iecr.1c00166

Comment on “CFD Modeling of CO2 Absorption in Membrane Contactors Using Aqueous Solutions of Monoethanolamine-Ionic Liquids”
DOI: 10.1021/acs.iecr.0c06231

Response to “Questionable Recyclable Catalyst: Comment on ‘O-Acetyl Substituted Phenol Ester Synthesis via Direct Oxidative Esterification Utilizing Ethers as an Acylating Source with Cu2(dhtp) Metal–Organic Framework as a Recyclable Catalyst’”
DOI: 10.1021/acs.iecr.1c00199


Inorganic Chemistry

***

A Year Like No Other
DOI: 10.1021/acs.inorgchem.0c03477

Tripodal P3XFe–N2 Complexes (X = B, Al, Ga): Effect of the Apical Atom on Bonding, Electronic Structure, and Catalytic N2-to-NH3 Conversion
DOI: 10.1021/acs.inorgchem.0c03354

Synthesis and Reactivity of Iron Complexes with a Biomimetic SCS Pincer Ligand
DOI: 10.1021/acs.inorgchem.0c03427

Excited-State Dynamics of [Ru(S–Sbpy)(bpy)2]2+ to Form Long-Lived Localized Triplet States
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.inorgchem.0c03163

Widening the Window of Spin-Crossover Temperatures in Bis(formazanate)iron(II) Complexes via Steric and Noncovalent Interactions
Open Access through ACS AuthorChoice
DOI: 10.1021/acs.inorgchem.0c03593


JACS Au

***

Metal–Micelle Cooperativity: Phosphine Ligand-Free Ultrasmall Palladium(II) Nanoparticles for Oxidative Mizoroki–Heck-type Couplings in Water at Room Temperature
Open Access Through ACS AuthorChoice
DOI: 10.1021/jacsau.0c00087

Transformation of Bulk Pd to Pd Cations in Small-Pore CHA Zeolites Facilitated by NO
Open Access Through ACS AuthorChoice
DOI: 10.1021/jacsau.0c00112

Active Phase on SrCo1–xFexO3−δ (0 ≤ x ≤ 0.5) Perovskite for Water Oxidation: Reconstructed Surface versus Remaining Bulk
Open Access Through ACS AuthorChoice
DOI: 10.1021/jacsau.0c00022

Alcohol-Assisted Hydrogenation of Carbon Monoxide to Methanol Using Molecular Manganese Catalysts
Open Access Through ACS AuthorChoice
DOI: 10.1021/jacsau.0c00091

Genetically Encoded Supramolecular Targeting of Fluorescent Membrane Tension Probes within Live Cells: Precisely Localized Controlled Release by External Chemical Stimulation
Open Access Through ACS AuthorChoice
DOI: 10.1021/jacsau.0c00069


Journal of Agricultural and Food Chemistry

***

LC–MS/MS Quantification Reveals Ample Gut Uptake and Metabolization of Dietary Phytochemicals in Honey Bees (Apis mellifera)
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jafc.0c03584

New Horizons in Agricultural and Food Sciences
DOI: 10.1021/acs.jafc.0c07777

Measurement of Saccharin and trans-Resveratrol Metabolites in Urine as Adherence Markers for Small Quantity Lipid-Based Nutrient Supplement Consumption
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jafc.0c06144

Systematic Review of Phenolic Compounds in Apple Fruits: Compositions, Distribution, Absorption, Metabolism, and Processing Stability
DOI: 10.1021/acs.jafc.0c05481

First Characterization of the Formation of Anthocyanin–Ge and Anthocyanin–B Complexes through UV–Vis Spectroscopy and Density Functional Theory Quantum Chemical Calculations
DOI: 10.1021/acs.jafc.0c06827


Journal of Chemical & Engineering Data

***

Journal of Chemical & Engineering Data: An Update from the Editorial Team
DOI: 10.1021/acs.jced.0c01080

Solubility of Amlodipine Besylate (Calcium Channel Blocker Drug) in Supercritical Carbon Dioxide: Measurement and Correlations
DOI: 10.1021/acs.jced.0c00913

Magnetic Metal–Organic Frameworks Embedded in a Reduced Graphene Oxide Hydrogel Network as a Promising Hybrid Nanocomposite for Cr(VI) and p-Nitrophenol Removal
DOI: 10.1021/acs.jced.0c00890

Measurement and PC-SAFT Modeling of the Solubility of Gallic Acid in Aqueous Mixtures of Deep Eutectic Solvents
DOI: 10.1021/acs.jced.0c00784

Preparation and Characterization of Highly Porous Cellulose Nanofibrils/Chitosan Aerogel for Acid Blue 93 Adsorption: Kinetics, Isotherms, and Thermodynamics Analysis
DOI: 10.1021/acs.jced.0c00872


Journal of Chemical Education

***

Work-Integrated Learning: A Game-Based Learning Activity That Enhances Student Employability
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jchemed.0c00919

Using 3D Printing to Visualize 2D Chromatograms and NMR Spectra for the Classroom
DOI: 10.1021/acs.jchemed.0c01130

Introducing the Journal of Chemical Education’s Special Issue on Chemical Safety Education: Methods, Culture, and Green Chemistry
DOI: 10.1021/acs.jchemed.0c01459

Analysis of Protonation Equilibria of Amino Acids in Aqueous Solutions Using Microsoft Excel
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jchemed.0c01144

Demonstration of the Influence of Specific Surface Area on Reaction Rate in Heterogeneous Catalysis
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jchemed.0c01101


Journal of Chemical Information and Modeling

***

Wrapping Up Viruses at Multiscale Resolution: Optimizing PACKMOL and SIRAH Execution for Simulating the Zika Virus
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jcim.0c01205

OpenChem: A Deep Learning Toolkit for Computational Chemistry and Drug Design
DOI: 10.1021/acs.jcim.0c00971

General Purpose Structure-Based Drug Discovery Neural Network Score Functions with Human-Interpretable Pharmacophore Maps
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jcim.0c01001

Conformational Changes of Thyroid Receptors in Response to Antagonists
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jcim.0c01403

SMILES to Smell: Decoding the Structure–Odor Relationship of Chemical Compounds Using the Deep Neural Network Approach
DOI: 10.1021/acs.jcim.0c01288


Journal of Chemical Theory and Computation

***

Accurate Reduced-Cost CCSD(T) Energies: Parallel Implementation, Benchmarks, and Large-Scale Applications
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.0c01077

Multilevel Density Functional Theory
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.0c00940

Coarse-Grained Force Fields from the Perspective of Statistical Mechanics: Better Understanding of the Origins of a MARTINI Hangover
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.0c00638

A Simple Range-Separated Double-Hybrid Density Functional Theory for Excited States
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.0c01135

Excited-State Geometry Optimization of Small Molecules with Many-Body Green’s Functions Theory
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jctc.0c01099


Journal of Medicinal Chemistry

***

Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases
DOI: 10.1021/acs.jmedchem.0c01511

Structure- and Similarity-Based Survey of Allosteric Kinase Inhibitors, Activators, and Closely Related Compounds
DOI: 10.1021/acs.jmedchem.0c02076

2021: A New Year and New Directions for the Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c02220

Discovery of Dosimertinib, a Highly Potent, Selective, and Orally Efficacious Deuterated EGFR Targeting Clinical Candidate for the Treatment of Non-Small-Cell Lung Cancer
DOI: 10.1021/acs.jmedchem.0c02005

Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC)
DOI: 10.1021/acs.jmedchem.0c01563


Journal of Natural Products

***

My 60-Year Love Affair with Natural Products
DOI: 10.1021/acs.jnatprod.0c01237

Planomonospora: A Metabolomics Perspective on an Underexplored Actinobacteria Genus
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jnatprod.0c00807

Cyclopeptides from the Mushroom Pathogen Fungus Cladobotryum varium
DOI: 10.1021/acs.jnatprod.0c00980

Cyclotides from Brazilian Palicourea sessilis and Their Effects on Human Lymphocytes
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jnatprod.0c01069

Expanding the Scope of Detectable Microbial Natural Products by Complementary Analytical Methods and Cultivation Systems
DOI: 10.1021/acs.jnatprod.0c00942


Journal of Proteome Research

***

Rising Stars in Proteomics and Metabolomics
DOI: 10.1021/acs.jproteome.0c01026

NMR Spectroscopic Windows on the Systemic Effects of SARS-CoV-2 Infection on Plasma Lipoproteins and Metabolites in Relation to Circulating Cytokines
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jproteome.0c00876

Automated 16-Plex Plasma Proteomics with Real-Time Search and Ion Mobility Mass Spectrometry Enables Large-Scale Profiling in Naked Mole-Rats and Mice
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jproteome.0c00681

Proteomic Approaches to Study SARS-CoV-2 Biology and COVID-19 Pathology
DOI: 10.1021/acs.jproteome.0c00764

Low Volume in Vitro Diagnostic Proton NMR Spectroscopy of Human Blood Plasma for Lipoprotein and Metabolite Analysis: Application to SARS-CoV-2 Biomarkers
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jproteome.0c00815


Journal of the American Chemical Society

***

Capturing the Moment of Emergence of Crystal Nucleus from Disorder
Open Access Through ACS AuthorChoice
DOI: 10.1021/jacs.0c12100

JACS 2021: A New Beginning
DOI: 10.1021/jacs.0c12916

Development of Antibody-Based PROTACs for the Degradation of the Cell-Surface Immune Checkpoint Protein PD-L1
DOI: 10.1021/jacs.0c10008

Enantioselective Synthesis of Euonyminol
DOI: 10.1021/jacs.0c12998

Organoiodine-Catalyzed Enantioselective Intermolecular Oxyamination of Alkenes
DOI: 10.1021/jacs.0c11440


Journal of the American Society for Mass Spectrometry

***

Ion Imaging of Native Protein Complexes Using Orthogonal Time-of-Flight Mass Spectrometry and a Timepix Detector
Open Access Through ACS AuthorChoice
DOI: 10.1021/jasms.0c00412

In Pursuit of Happiness
DOI: 10.1021/jasms.0c00411

Faces of Mass Spectrometry/Laura Sanchez
DOI: 10.1021/jasms.1c00002

Nontargeted Analysis of Face Masks: Comparison of Manual Curation to Automated GCxGC Processing Tools
DOI: 10.1021/jasms.0c00318

Solving Complex Biologics Truncation Problems by Top-Down Mass Spectrometry
DOI: 10.1021/jasms.0c00343


Langmuir

***

Nanoscale Hydration in Layered Manganese Oxides
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.langmuir.0c02592

Recent Developments and New Directions for Langmuir
DOI: 10.1021/acs.langmuir.0c03563

Bulk Phase Behavior vs Interface Adsorption: Specific Multivalent Cation and Anion Effects on BSA Interactions
DOI: 10.1021/acs.langmuir.0c02618

Nucleotide Interaction with a Chitosan Layer on a Silica Surface: Establishing the Mechanism at the Molecular Level
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.langmuir.0c03050

Adaptation of a Styrene–Acrylic Acid Copolymer Surface to Water
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.langmuir.0c03226


Macromolecules

***

Diversity of Synthetic Approaches to Functionalized Perfluoropolyalkylether Polymers
DOI: 10.1021/acs.macromol.0c01599

Control of Particle Size in the Self-Assembly of Amphiphilic Statistical Copolymers
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.macromol.0c02341

Strong Reduction of the Chain Rigidity of Hyaluronan by Selective Binding of Ca2+ Ions
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.macromol.0c02242

Synthesis of Highly Transparent Diblock Copolymer Vesicles via RAFT Dispersion Polymerization of 2,2,2-Trifluoroethyl Methacrylate in n-Alkanes
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.macromol.0c02646

Highly Stretchable, Ultratough, and Strong Polyesters with Improved Postcrystallization Optical Property Enabled by Dynamic Multiple Hydrogen Bonds
DOI: 10.1021/acs.macromol.0c02628


Molecular Pharmaceutics

***

COVID-19 Transmission, Current Treatment, and Future Therapeutic Strategies
DOI: 10.1021/acs.molpharmaceut.0c00608

Revealing the Dynamic Mechanism by Which Transferrin Promotes the Cellular Uptake of HAIYPRH Peptide-Conjugated Nanostructures by Force Tracing
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.molpharmaceut.0c01119

In Vitro and In Vivo Studies on HPMA-Based Polymeric Micelles Loaded with Curcumin
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.0c01114

Relevance of Electrostatics for the Interaction of Tyrosine Hydroxylase with Porous Silicon Nanoparticles
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.molpharmaceut.0c00960

Nanobody–siRNA Conjugates for Targeted Delivery of siRNA to Cancer Cells
DOI: 10.1021/acs.molpharmaceut.0c01001


Nano Letters

***

An Anode-Free Zn–MnO2 Battery
DOI: 10.1021/acs.nanolett.0c04519

Bio-Inspired Lotus-Fiber-like Spiral Hydrogel Bacterial Cellulose Fibers
DOI: 10.1021/acs.nanolett.0c03707

Visualizing Ultrafast Electron Transfer Processes in Semiconductor–Metal Hybrid Nanoparticles: Toward Excitonic–Plasmonic Light Harvesting
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.nanolett.0c04614

Nanoscale Probing of Image-Potential States and Electron Transfer Doping in Borophene Polymorphs
DOI: 10.1021/acs.nanolett.0c04869

Phonon-Assisted Hot Carrier Generation in Plasmonic Semiconductor Systems
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.nanolett.0c04419


Organic Letters

***

Csp3–H Trifluoromethylation of Unactivated Aliphatic Systems
DOI: 10.1021/acs.orglett.0c03891

Challenges and More Challenges
DOI: 10.1021/acs.orglett.0c03811

Total Synthesis of ent-Plagiochianin B
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.orglett.0c04219

Interrupting the Barton–McCombie Reaction: Aqueous Deoxygenative Trifluoromethylation of O-Alkyl Thiocarbonates
DOI: 10.1021/acs.orglett.0c04039

Nickel-Catalyzed Reductive 2-Pyridination of Aryl Iodides with Difluoromethyl 2-Pyridyl Sulfone
DOI: 10.1021/acs.orglett.0c03939


Organic Process Research & Development

***

Some Items of Interest to Process R&D Chemists and Engineers
DOI: 10.1021/acs.oprd.0c00546

Palladium-Catalyzed C–N Coupling of Pyrazole Amides with Triazolo- and Imidazopyridine Bromides in Ethanol
DOI: 10.1021/acs.oprd.0c00437

Explosive Hazard Identification in Pharmaceutical Process Development: A Novel Screening Method and Workflow for Shipping Potentially Explosive Materials
DOI: 10.1021/acs.oprd.0c00467

Implementing Continuous Manufacturing for the Final Methylation Step in the AMG 397 Process to Deliver Key Quality Attributes
DOI: 10.1021/acs.oprd.0c00440

Development and Scale-Up of a Direct Asymmetric Reductive Amination with Ammonia
DOI: 10.1021/acs.oprd.0c00522


Organometallics

***

Synthesis of NHC-Iridium(III) Complexes Based on N-Iminoimidazolium Ylides and Their Use for the Amine Alkylation by Borrowing Hydrogen Catalysis
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.organomet.0c00726

Pioneers and Influencers in Organometallic Chemistry: Professor Robert Crabtree’s Storied Career via an Unusual Journey to the Ivy League
DOI: 10.1021/acs.organomet.0c00797

Catalytic Deoxygenation of Nitroarenes Mediated by High-Valent Molybdenum(VI)–NHC Complexes
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.organomet.0c00352

Beyond Ni{N(SiMe3)2}2: Synthesis of a Stable Solvated Sodium Tris-Amido Nickelate
DOI: 10.1021/acs.organomet.0c00785

Switchable Imine and Amine Synthesis Catalyzed by a Well-Defined Cobalt Complex
DOI: 10.1021/acs.organomet.0c00727


The Journal of Organic Chemistry

***

An Organic Chemist’s Guide to N-Nitrosamines: Their Structure, Reactivity, and Role as Contaminants
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.joc.0c02774

Asymmetric Total Synthesis of (−)-Spirochensilide A, Part 1: Diastereoselective Synthesis of the ABCD Ring and Stereoselective Total Synthesis of 13(R) Demethyl Spirochensilide A
DOI: 10.1021/acs.joc.0c02494

Isomerization and Fragmentation Reactions on the [C2SH4] Potential Energy Surface: The Metastable Thione S-Methylide Isomer
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.joc.0c02835

Asymmetric Total Synthesis and Revision of Absolute Stereochemistry for (+)-Taumycin A: An Approach that Exploits Orthogonally Protected Quasienantiomers
DOI: 10.1021/acs.joc.0c02820

Photocatalytic Reductive C–O Bond Cleavage of Alkyl Aryl Ethers by Using Carbazole Catalysts with Cesium Carbonate
DOI: 10.1021/acs.joc.0c02663


The Journal of Physical Chemistry A

***

Photoelectron Spectra of Gd2O2– and Nonmonotonic Photon-Energy-Dependent Variations in Populations of Close-Lying Neutral States
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jpca.0c11002

Near-Infrared Spectra of High-Density Crystalline H2O Ices II, IV, V, VI, IX, and XII
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpca.0c09764

Chemistry and Photochemistry of Pyruvic Acid at the Air–Water Interface
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpca.0c09096

Controlling the Photostability of Pyrrole with Optical Nanocavities
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpca.0c09252

Triplet State Baird Aromaticity in Macrocycles: Scope, Limitations, and Complications
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpca.0c08926


The Journal of Physical Chemistry B

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Molecular Simulations of Hydrophobic Gating of Pentameric Ligand Gated Ion Channels: Insights into Water and Ions
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.0c09285

Discriminating between Concerted and Sequential Allosteric Mechanisms by Comparing Equilibrium and Kinetic Hill Coefficients
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.0c09351

Structure–Function Properties in Disordered Condensates
DOI: 10.1021/acs.jpcb.0c11057

Electron Spin Relaxation Studies of Polydopamine Radicals
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.0c10485

RNA Pore Translocation with Static and Periodic Forces: Effect of Secondary and Tertiary Elements on Process Activation and Duration
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcb.0c09966


The Journal of Physical Chemistry C

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Shapes and Shape Transformations of Solution-Phase Metal Particles in the Sub-nanometer to Nanometer Size Range: Progress and Challenges
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jpcc.0c10159

First-Principles Study of Na Intercalation and Diffusion Mechanisms at 2D MoS2/Graphene Interfaces
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.0c10107

Tracking Ions the Direct Way: Long-Range Li+ Dynamics in the Thio-LISICON Family Li4MCh4 (M = Sn, Ge; Ch = S, Se) as Probed by 7Li NMR Relaxometry and 7Li Spin-Alignment Echo NMR
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.0c10224

Structural Evolution of Ga–Cu Model Catalysts for CO2 Hydrogenation Reactions
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.0c09382

Influence of Oxygen Vacancies on the Structure of BiVO4
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpcc.0c08751


The Journal of Physical Chemistry Letters

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Opportunities for Next-Generation Luminescent Materials through Artificial Intelligence
Open Access Through ACS Editors’ Choice
DOI: 10.1021/acs.jpclett.0c03203

Impact of Glycans on Lipid Membrane Dynamics at the Nanoscale Unveiled by Planar Plasmonic Nanogap Antennas and Atomic Force Spectroscopy
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.0c03439

Tuning Transition Electric and Magnetic Dipole Moments: [7]Helicenes Showing Intense Circularly Polarized Luminescence
DOI: 10.1021/acs.jpclett.0c03174

Spectroscopic Determination of Key Energy Scales for the Base Hamiltonian of Chromium Trihalides
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.0c03476

Effective Negative Diffusion of Singlet Excitons in Organic Semiconductors
Open Access Through ACS AuthorChoice
DOI: 10.1021/acs.jpclett.0c03171

Celebrating African American Chemists: Renã A. S. Robinson

February is Black History Month in the United States. This year, ACS Axial is looking forward and highlighting noteworthy African American chemists working today, engaging them in conversation about their life and work.

Renã A. S. Robinson is an Associate Professor of Chemistry and the Dorothy J. Wingfield Phillips Chancellor’s Faculty Fellow at Vanderbilt University.

How would you describe the current focus of your work?

Right now, my work is focused on using advanced proteomics technologies, as well as lipidomic ones, to understand health disparities in Alzheimer’s disease. We’re really interested in trying to determine what molecular contributions are associated with African American/Black adults having higher incidence rates of Alzheimer’s Disease. To do that, we’re generating molecular signatures of Alzheimer’s Disease in African American as well as non-Hispanic white and Hispanic/Latino populations and trying to understand how similar and how different those signatures of Alzheimer’s Disease are, as well as also evaluating risk factors for Alzheimer’s Disease, such as hypertension.

How did you first become interested in your field?

My interests go back to my undergrad/grad school transition, in which I was trying to determine my route to graduate school. I thought that was going to be in organic chemistry because I was interested in starting a cosmetics company. I found out when I was interviewing for different graduate programs and learned what it would take to get a Ph.D. in organic chemistry, that that was not for me. So I instead became more interested in the groups that were doing mass spectrometry and were looking at peptides and proteins, and that’s what I could wrap my head around more. That’s how I started doing analytical chemistry as a grad student. If I actually think back, I did have an undergrad research project where I was using gas chromatography and mass spectrometry to look at fish oils for glaucoma purposes. I guess that was kind of my intro.

What about chemistry in general? When did you first encounter it?

I was in a number of different programs when I was in elementary school, as well as in middle school, that exposed me to math and science, so I can’t put a particular date to it. But I do know that I had a lot of extensive experience, especially when I got to middle school. I was in a program that was called the Whitney M. Young Scholars Program, and we spent summers on college campuses and got exposed to chemistry, biology, and other sorts of college-level science, as well as math courses. Then I participated in a program in high school, which was Math and Science for Minority Students (MS2) at Philips Academy in Andover and was also exposed to a lot of chemistry outside of just what I was getting inside my high school classroom.

Who were your mentors? And how did they impact your career?

I’ve had many mentors along the way. When I think about my graduate career, my research advisor was one of my first mentors. He was very impactful in terms of helping me to think outside of the box. Also, he was very helpful at just encouraging me to keep going at times when I felt like science was difficult. There have been a number of African American scientists and professors that I have relied on throughout the years to stay in the field and know how to navigate challenges along the way. As for other underrepresented individuals in science, I’ve been fortunate to find some really good people that I’ve been able to rely on, who are more senior. Too many to name but I appreciate every one of them.

What’s a piece of advice you wished you’d received before you started your career in chemistry?

That rejection in chemistry is a lifestyle or would be a lifestyle and it’s up to me to decide how to bounce back. I think I didn’t anticipate how much work that I would put into something for someone else to criticize or to say no in terms of funding, papers, or just ideas in general. I think if I was given some advice in terms of “just expect that this is a part of pursuing chemistry, especially doing it in academia, but it’s something that everyone experiences”, it wouldn’t have knocked me off my feet as much as it did when I first got going with my own independent lab.

How do you bounce back from rejection?

This just happened today, so I think the immediate first best thing to do is to take a step back and put it away. For me, that means once I see the rejection, I have to give myself some time and space to put my emotions to the side and work through my emotions about it, so that I can go back and actually try to read the criticisms and see where the points are valid and objective and how I can best respond to them. For me, it’s been to just give some time and space to actually work through my emotions before I go back in and respond.

You’re in a position now where you’re starting to mold the next generation of chemists; what do you think makes a good mentor? Or what are the qualities that you try to bring to that role?

I think the first thing is just having a heart for it. I think you have to be an individual who truly and genuinely cares about others and the success of other individuals, especially if you want to be helpful to them. I think really good mentors listen and really try to understand what it is that their mentees need, which may not be what you anticipate that they need in the beginning. I think really good mentors also go above and beyond sort of the call of duty and are willing and able to do that. If you have a mentee who you’re mentoring and they’re coming to you with a particular question or set of problems that are not what you had initially signed up for in mentoring, a really good mentor sees how to navigate that. And if they can’t help to navigate the problem, then they’re willing to go out and find the person who can.

STEM continues to be a field where African Americans are under-represented. What needs to change in chemistry in order for that to be amended?

Institutions, whether they’re academic, industrial, or government, I think they really have to put up in terms of where they are. I think a lot of companies say they want to have diverse, inclusive, and equitable environments but haven’t figured out how to do that best. I think they really have to put in more to figuring out and following up on creating DEI environments and spaces.

Recruitment has one part to do with that, in terms of getting people in the door that come from under-represented groups, but really the bulk of it has to do with sustaining that and retaining those individuals in those fields. I think in each institution, it boils down to figuring out what are the barriers within the institutional environment that are preventing individuals from diverse groups from staying in that particular institution. I think for chemistry, the field is an institution. But really, it’s represented among many different companies and labs regardless of what sector they come from. I think each individual institution has to do its part to remove those barriers to impact chemistry as a whole.

What are the characteristics of an organization that does a good job of retaining people of color?

They create spaces where people feel welcome. Spaces where everyone feels like they have a right to use their voice and they feel open enough to use their voice. There’s space where creativity and differences are appreciated, and so when you have individuals who walk into a room, and they share their brilliant science ideas with other individuals, instead of those ideas being shot down, the reception in good places is, ‘ok, how can we build those ideas up? How can we turn those into feasible ones?’ They’re ones where individuals can see a reflection of themselves in the spaces that they work. Companies that do a really good job with this, they have good representation of individuals from different backgrounds. I think that’s part of what they’re doing well.

What do you wish I’d asked you?

‘Why haven’t we figured this out yet?’ is what I wished you’d asked me. Why is it in the context of everything that’s happening in the world today, and I would say that it’s even been happening in terms of injustices across the board, especially in science? Why haven’t we figured out how to do this better? Why has it taken really drastic things happening in our society for institutions to really wake up and step up at doing their part in terms of creating diverse and equitable environments? I don’t know why we haven’t figured that out fully yet, but I do hope that due to current events and all of the positive chatter that is taking place at a lot of institutions [and you see this in publications and in conversations on social media], that institutions will really do their part to help in this conversation. Basically, doing what needs to be done so there’s a fair representation of all individuals that need to be represented especially Black and Brown individuals in chemistry.

Why do you think it has taken that long?

Because I think it’s easy to turn a blind eye to things that don’t impact you, right? And whether that’s ignorance or it just doesn’t impact me, so I don’t have to pay as much attention to it – it’s easy to do. I also think because there hasn’t been as much weight on hearing the collective voices of so many under-represented groups and allies of under-represented groups in terms of addressing these issues. I do feel like, in light of everything that’s happened in the last year, that it’s really been a good time and an impactful time for individuals to feel free enough to speak out and say now, ‘Actually this isn’t just happening to George Floyd, these things are happening to us, metaphorically, in other environments, like in chemistry and in academia and in these different companies.’ You know, we’re very few, and so I think it’s been important for us to have a space to speak, and I think we’ve been able to be heard because it’s not just one individual speaking, it’s thousands of individuals that are speaking and addressing these issues right now.

Read Renã A. S. Robinson’s Papers in ACS Publications Journals.

SciMeetings Spotlight: Torsten John

This interview is part of a series highlighting exceptional chemists who have shared their conference poster or presentation through SciMeetings. Launched by ACS Publications as a virtual science sharing platform in March 2020, SciMeetings helps presenters increase the global visibility and extend the longevity of the research they present at conferences.

Torsten John is a Postdoctoral Researcher in the MIT Department of Biological Engineering. Below he discusses his presentation  ‘Impact of nanostructured surfaces on the aggregation of amyloidogenic peptides‘ from the ACS Fall 2020 Virtual Meeting.

What’s your research focus? What attracted you to this field?

I am a biophysical and computational chemist and study the self-assembly behavior of biomolecules in solution and at interfaces, such as cell membranes or nanoparticles. In my Ph.D. research at the Leibniz Institute of Surface Engineering (IOM) in Leipzig (Germany) and at Monash University in Melbourne (Australia), my studies focused on peptide aggregation processes in the context of neurodegenerative diseases, such as Alzheimer’s. In particular, I was interested in how nanostructured surfaces influence peptide adsorption and aggregation when they interact. For my Postdoc research at the Massachusetts Institute of Technology (MIT) in the U.S., I apply my knowledge and experience from my Ph.D. to design 2D and 3D self-assembled DNA nanostructures. I have always been excited to understand biomolecules and biomolecular processes at a molecular level and then use that knowledge to design biomaterials or strategies to combat disease.

Who are your mentors? How have they impacted your work so far?

I have been working in several research groups and thus benefited from the mentoring by many researchers. The most important people in my academic career have been my Ph.D. advisors Professor Bernd Abel (Leipzig, Germany), Associate Professor Lisandra L. Martin (Melbourne, Australia), and Assistant Professor Jelger Risselada (Göttingen, Germany). While I was enrolled as a Ph.D. student in Germany, I spent more than one year of my research time in Australia. This trained my communication skills and planning as well as coordination of my project between my advisors. The most helpful advice has been critical feedback on both my ideas and manuscript drafts, as well as the design of future research directions.

Where did you get the idea for the research presented in your talk?

At the ACS Fall 2020 Virtual Meeting, I presented a talk with the main results from my Ph.D. research on the ‘Impact of nanostructured surfaces on the aggregation of amyloidogenic peptides.’ The initial idea for this research was a combination of my interests in studying amyloid peptide aggregation and an existing DFG project that my supervisor (Professor Bernd Abel) was working on. In addition, the research was further specified in collaboration with my advisor in Australia (Associate Professor Lisandra L. Martin), particularly in the direction of peptide-membrane interactions. The goal was to understand how nanoparticles influence peptide aggregation at a molecular level, and thus potentially disease development. Nanoparticles are part of several cosmetics and exhaust fumes, and their impact on health has not been fully understood.

What do you think is the most important unsolved problem in your field right now?

In the context of peptide aggregation, many studies have been performed to study the molecular processes of folding, misfolding, and aggregation into amyloid fibrils, as well as to identify the toxic species. However, it is still very unclear whether amyloid fibrils and amyloidogenic peptides, in general, are the cause of disease or whether their aggregation is a side effect of the disease-causing process.

What advice would you give to anyone presenting a poster or talk for the first time?

I can only advise you to always present your research when you attend a conference or meeting and start doing that early on in your career. Like with many other things in life, it takes time and practice to master your communication skills. Thus, I recommend preparing it several weeks in advance of the first poster talk, even if that means you cannot present the most recent results. This provides enough time to revise it and obtain feedback from colleagues in practice presentations at, e.g., a group meeting. Several resources can be found online.

Is there added value in presenting your research on SciMeetings?

While I value the in-person exchange at physical conferences and meetings, SciMeetings enables researchers from all over the world without the need to travel access to your presentation. Further, it can be viewed at an individual time independent of the time zone, and it is available in the future so that you can direct collaborators or others to your past work.

Explore more research on SciMeetings and learn more about benefits for presenters. Interested in presenting your conference material? Join us for #ACSSpring2021, taking place online April 5-30. Register now and submit your abstract. Then, visit the Registration Resource Center to add SciMeetings on to your registration.

The 26th Annual Lorne Proteomics Symposium

The 26th annual Lorne Proteomics Symposium, organized by the Australasian Proteomics Society, was held virtually and in-person in both Lorne and Sydney from February 4th-5th.

Throughout the conference, scientists, laboratory managers, and students with a common interest in proteomics shared their latest findings, and were able to learn more about the latest developments and technologies to help them facilitate their research.

This year, Analytical Chemistry, Biochemistry, and Journal of Proteome Research sponsored this meeting. Learn more about the topics covered in each journal by exploring each journal’s featured content below

Analytical Chemistry 

Separation of Isobaric Mono- and Dimethylated RGG-Repeat Peptides by Differential Ion Mobility-Mass Spectrometry
Daniel L. Winter, Jordan Mastellone, K. M. Mohibul Kabir, Marc R. Wilkins, and William A. Donald
DOI: 10.1021/acs.analchem.9b02504

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Antibody-Free Targeted Proteomics Assay for Absolute Measurement of α-Tubulin Acetylation
Alok K. Shah, Gautam Wali, Carolyn M. Sue, Alan Mackay-Sim, and Michelle M. Hill
DOI: 10.1021/acs.analchem.0c01683 

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Systematic Error Removal Using Random Forest for Normalizing Large-Scale Untargeted Lipidomics Data
Sili Fan, Tobias Kind, Tomas Cajka, Stanley L. Hazen, W. H. Wilson Tang, Rima Kaddurah-Daouk, Marguerite R. Irvin, Donna K. Arnett, Dinesh K. Barupal, and Oliver Fiehn
DOI: 10.1021/acs.analchem.8b05592 

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Characterization and Optimization of Multiplexed Quantitative Analyses Using High-Field Asymmetric-Waveform Ion Mobility Mass Spectrometry
Devin K. Schweppe*, Satendra Prasad, Michael W. Belford, José Navarrete-Perea, Derek J. Bailey, Romain Huguet, Mark P. Jedrychowski, Ramin Rad, Graeme McAlister, Susan E. Abbatiello, Eloy R. Woulters, Vlad Zabrouskov, Jean-Jacques Dunyach, João A. Paulo, and Steven P. Gygi*
DOI: 10.1021/acs.analchem.8b05399 

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Sample Multiplexing Strategies in Quantitative Proteomics
Albert B. Arul and Renã A. S. Robinson*
DOI: 10.1021/acs.analchem.8b05626 

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Biochemistry Articles

Chemoproteomic Profiling of O-GlcNAcylation in Caenorhabditis elegans
Wei Qin, Zhongyun Xie, Jingyang Wang, Guangshuo Ou, Chu Wang, and Xing Chen
DOI: 10.1021/acs.biochem.9b00622 

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Net Charge and Nonpolar Content Guide the Identification of Folded and Prion Proteins
Susanna K. Yaeger-Weiss, Theodore S. Jennaro, Miranda Mecha, Jenna H. Becker, Hanming Yang, Gordon L. W. Winkler, and Silvia Cavagnero
DOI: 10.1021/acs.biochem.9b01114 

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Protein Farnesyltransferase Catalyzes Unanticipated Farnesylation and Geranylgeranylation of Shortened Target Sequences
Sudhat Ashok, Emily R. Hildebrandt, Colby S. Ruiz, Daniel S. Hardgrove, David W. Coreno, Walter K. Schmidt, and James L. Hougland
DOI: 10.1021/acs.biochem.0c00081 

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Chemoselective Methionine Bioconjugation on a Polypeptide, Protein, and Proteome
Jia Zang, Yulin Chen, Wenxuan Zhu, and Shixian Lin
DOI: 10.1021/acs.biochem.9b00789 

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APEX Proximity Labeling as a Versatile Tool for Biological Research
Thanh My Thi Nguyen, Junhyung Kim, Thi Tram Doan, Min-Woo Lee, and Mihye Lee
DOI: 10.1021/acs.biochem.9b00791 

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Journal of Proteome Research Special & Virtual Issues

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These journals are also sponsoring individual awards. Learn more about each and how you can contribute.

Common Questions About Publishing Your Polymer Research in Macromolecules

Macromolecules recently held a webinar with Editor-in-Chief Marc A. Hillmyer and Associate Editors Arthi Jayaraman and Chinedum Osuji. The session addressed a number of questions that authors often have about submitting their work to the journal.

Read on to learn the answers to these common questions.

Marc A. Hillmyer

How are the reviewers chosen? Are the author suggestions taken into consideration?

We review the author recommendations for reviewers. It is good practice to provide the suggestions and justifications for your suggestions. There are many factors that go into our decision of which reviewers to choose. We use our best judgement and also availability of the reviewers to determine who is selected.

When associate editors decide to not send out a manuscript for review, how is that decision communicated to the authors?

The decision to not send a paper for review is made very carefully. After reviewing the paper, we ask ourselves does this fit within in the scope of the journal, what is the significance, and what is the potential impact of the work; thus a manuscript that does not go out for external peer review, has also been reviewed by at least one editor at Macromolecules. We do our best to communicate our specific reasoning individually to the author for such a decision.

Does the three-week to review timeframe apply to all types of manuscripts?

We only have two manuscript types: Articles and Perspectives. We chose a three-week allowed time for review to balance respect for the reviewers’ time and the author(s) desire for a speedy yet careful decision. We allow for longer review time in the case of Perspectives.

Chinedum Osuji

How do you decide if one of the two reviewers does not suggest to publish the work, while as other does?

All Associate Editors at Macromolecules are practicing scientists in the fields in which they are associated with who bring their own expertise and understanding to the journal’s team. This enables them to make a judgement of substantive reviewer comments, even in case of conflicting reviewer comments. In some particularly difficult situations, it can be prudent to use an adjudicating reviewer to get another perspective.

ACS recently announced a suite of new open access journals, including ACS Polymers Au. How does Macromolecules envision interacting with this new open-access journal?

ACS Publications has an array of open access options; ACS Central Science, ACS Omega, JACS Au, and the new suite of nine open access journals, ACS Au. ACS Polymers Au is part of this new group. We view this positively for giving authors more options for publishing their work, especially when funding agencies may mandate open access for publishing their research outcomes. We believe that this is a positive development and are committed to an ecosystem in which these journals exist and benefit from one another.

*Disclosure: Since the recording of this webinar, Arthi Jayaraman has joined ACS Polymer AU as the Deputy Editor.

Many studies are quite interdisciplinary and limiting the scope of a paper can be challenging. Do you see it as an advantage to share a broader story, combining, for example, computer simulations, mathematical modelling, synthesis work and detailed characterization? Or is it better to keep a narrow focus and not try to convey the broader perspective?

It depends on how the story is communicated and if there is new science being presented. We want the content of the paper to be convincing and novel, and that brings out the fundamental science of polymers and pushes the field forward. There should be one or two significant points that will get elevated by the narrative for the reader to appreciate. The presence of additional data should not distract or detract from your main points. Also, consider using the supporting information in your manuscript wisely.

Arthi-Jayaraman

When papers combine “Materials Science” field (Polymerization and Characterization) with “Biology” (assays involving cell cultures in vitro, e.g. testing Biocompatibility of materials), does it fit Macromolecules scope?

It can, but the more it leans on the biological emphasis, the better it may do in another ACS journal with that focus. At Macromolecules, our focus is on evaluating if the central point of the manuscript will advance fundamental polymer science.

What should you do when you run into technical or financial difficulties to get additional characterization data asked for by reviewers (for e.g., needing new GPC detectors or columns, mechanical testing instruments, etc.)?

This is an important point, especially during COVID-19. We at Macromolecules are taking a reasonable approach and want to be as helpful towards our authors as we can be. Editors are paying special attention to determining what information is necessary and what criticisms are reasonable towards a manuscript getting published in the journal.

Can the Editor decide to accept the manuscript without sending it for external review? How does the editor make such a decision? How often does that happen?

Yes, they can. It does not happen too often, but the most frequent cases are manuscripts that come to us as a result of transfer from another ACS journal. These are often papers that may be out of scope at another journal but constitute a good fit for Macromolecules. Also transfers can come in with reviews received at the other journal and associated author responses, helping to reach a decision without having to send the manuscript out for another round of peer review.

Sometimes there is a subtle line between what should be published in Macromolecules and what is more appropriate for another journal, say Inorganic Chemistry, for example. Some polymers are obtained through the employment of suitable organometallic catalysts and characterization of these systems is something important to conduct besides explore the properties of the material. What would make an article more appropriate for Macromolecules? What is the best way to focus the manuscript?

This is a fine line to be balanced. The question to ask here is, “Is the point to advance fundamental polymer science?” The paper should provide a use to the polymer community.

Some ACS journals recently inaugurated Early Career Boards. Does Macromolecules plan a similar initiative?

We have an Editorial Advisory Board that includes several young researchers who have been invited to join the board and contribute their expertise. Macromolecules has not formally initiated an Early Career Board, but it is under consideration. It is an ongoing discussion about how best to engage our future researchers with the journal.

How difficult can it be for an AE or reviewer to remain unbiased if the reviewer happens to review a manuscript that is very close to their own field or from authors that have some kind of conflict with?

In case of any conflicts of interest, Editors recuse themselves from handling the manuscript. We are comprised of subject matter experts, and we each have our own knowledge. However even in cases where a submission maybe closely related to the Editor’s own work, we do the best we can to evaluate the papers on their own merits. We use a diversity of reviewers to provide us their individual assessments. This is the central tenet of what associate editors do. We agree that it is important that the science be evaluated on its merits and use our reviewers to lend their expertise and understanding.

When does the journal check for plaigerism? Are these checks always communicated to the author?

Plagiarism is taken very seriously at Macromolecules. We use a program called CrossCheck by iThenticate to screen for overlapping content. Every revised manuscript from authors is evaluated by this program.

Celebrating African American Chemists: Davita L. Watkins

February is Black History Month in the United States. This year, ACS Axial is looking forward and highlighting noteworthy African American chemists working today, engaging them in conversation about their life and work.

Davita L. Watkins is an Associate Professor of Chemistry & Biochemistry at the University of Mississippi.

Can you describe the current focus of your work?

I’m a synthetic organic chemist. I usually tell people that I’m an organic chemist with a little bit of an edge to her, because the research that we do is at the interface of physical organic chemistry, which is a domain of organic chemistry and more materials science and some polymer chemistry, application-wise.

My research right now is actually going in another direction. I started my independent career doing mostly supermolecular chemistry, solid-state chemistry, understanding how we can take bottom approaches to materials, and focusing a lot on energy. Right now, my research is more into nanotechnology, bio-imaging, self-assembling of polymeric structures, aqueous media, and seeing how we can apply them to nanomedicine – theranostic, bioimaging, drug delivery, areas like that. I still am interested in energy-related research, focusing a lot on polymeric chemistry and conjugated materials that can be used to develop these organic-based solar cells and different types of organic-based devices. So my heart is still there, but my interest right now and my group is really excited about the concepts of nanoparticles and nanoscience, and nanotechnology. I think that the science behind the COVID vaccine has really boosted our interest as well.

How did you become interested in your field? How did you make the swerve into nanoscience?

Most chemists probably say, ‘oh, I had a great high school chemistry teacher, I had a great AP and honors chemistry teacher.’ I grew up in Memphis, Tennessee, and that really kind of pushed my drive towards science. But I think graduating with my doctoral degree was the deciding factor for me in trying to figure out what I wanted to do in my independent career and where I wanted to see myself in chemistry.

My doctoral studies were very much at the borderline of organic chemistry and materials science. I studied stimuli response materials, looking at photochromes that can be placed inside the backbone of polymers and seeing how we can use those for a variety of applications. But I was also really fortunate to be able to go into a supramolecular chemistry group as a postdoc. My postdoc mentor, Ronald K. Castellano, was very influential in giving me the basics and helping me understand the pure concepts of physical organic chemistry, and pushing the edges of my knowledge of science. He really helped me mold and craft that love for it.

Who were your early mentors? And how did they impact your career?

I had to reach out to more unconventional means of mentorship. One thing I was really appreciative of as a graduate student was being accepted into a cohort. I would say that my early mentors were my peers from my graduate cohort and then, of course, being able to reach out to people at different universities or institutes.

My doctoral mentor, Tomoko Fujiwara, of course. She’s the first woman that I really knew in academia. She really helped set the foundation for me to see really strong women who are doing science. And then also Fatima Rivas,  who was at St. Jude research hospital then, now at LSU. And then a really amazing postdoc, Alexandra Kikonyogo, who was at the University of Memphis, but now she works as a consultant at NIH. They’ve been some amazing mentors and interestingly enough, they’re all women.

STEM continues to be a field where African Americans are under-represented. What do you feel needs to change in the field for that to be addressed?

The STEM pipeline is a very difficult challenge, because we know it goes all the way back to elementary school. People try to tap into the pipeline at maybe middle school or high school. But the big thing for us is trying to relate to the minority community.

When we think about smart kids growing up, quite often, people say ‘you’re going to be a doctor,’ ‘you’re going to be a lawyer,’ ‘you’re going to be an engineer.’ We say those things, because those things are relational. We see doctors on a regular basis. We see lawyers, we see accountants and everything else, but how many of us actually get to see a scientist with a Ph.D.? If we can actually take time to show representation of different types of people who are succeeding and showing different routes when it comes to where you can be in your career, I think that would be helpful. Because the more you see, the more you’ll be able to say, ‘hmm, maybe I could do that.’

What I find fascinating, being at the University of Mississippi, is for most students, I’m the first Black female that they’ve ever had as a professor, and I’m the first one that they get to see, and most students are kind of shocked. They’re like, ‘wait, wait a minute, I didn’t even know this existed, and she has a research group, and she’s doing some really cool research.’ I find that a lot of young women of all races do come into my office and say, ‘Wow, I can actually do this. I never knew I could do something like this because I’ve never seen this before.’

What’s one piece of advice you wished you’d received before you started your career in chemistry? 

I hear this more now in my later career or my mid-career than I did earlier, but I hear the phrase, ‘It’s not a sprint, it’s a marathon.’ I wish that I had taken heed to that a little bit earlier, because you need to realize that even the small wins are important. Being able to say you published a manuscript, even if it’s not a JACS or a Nature, or being able to say you wrote your first manuscript or being able to say you presented at your first conference – those small wins build up to something. We should really celebrate those wins. I’m still having a hard time celebrating those things.

Do you think that’s something that is unique to academia or science? Or is that more universal, do you think? 

I think it’s an aspect of very ambitious people and perfectionists, but I also think it’s in academia. I think you see a very striking difference with the next generation of scientists, but we’re criticized; we’re trained to be critical. We’re constantly being criticized or picked over with our research and thoughts and everything else. So it’s very difficult to be like, ‘Oh, this is great,’ when you’re looking over and see you missed a period or should’ve said this statement, or should’ve done this. So sometimes we just have to take a birds-eye view and be like, ‘You published in JACS or you published in Nature – be excited about that!’

I noticed that your lab has a Twitter account. What do you think the role of social media is in science?

I recently joined Twitter, and I did it right when I got tenure. I don’t know how people have time to do all of this; I don’t have time. But one of my colleagues was talking about Twitter and Instagram and the fact that he feels he’s been able to keep up with the most up-and-coming or emerging science because of it. And I agree! I’ve been able to read it so fast and share data quickly with individuals and able to go to talks that I wouldn’t be able to go to because of social media.

Do you think it has a role to play in elevating the work of African American scientists?

I think so. I really do feel as if there is a lot to show now. And I say that because, for a long time, there was a group or marginalized group of individuals that you really didn’t know about, but now you realize, ‘Hey, there are more of us! And they do research that is similar to mine or compatible to mine. Maybe I can reach out to them and have a collaboration. So I’ve actually done that; I’ve started a few collaborations with people that I’ve seen that were in the same circle, but I didn’t even know about, because you are just in your silo, and you realize there’s someone who is interested in the same thing you’re interested in

Where do you want to be in 10 years? And African American chemists in general, what do you think the trajectory for them is like?

For a long time, it’s been between 4%-8% of STEM Ph.D.s going to Black and African American individuals, leveling off between that average. But I see that it may be increasing now and that’s encouraging. I see that there will possibly be an increase in diversity in the STEM fields. I hope that there will be more individuals interested in STEM because they see that the culture is changing, the landscape is changing.

Read Davita L. Watkins’s papers in ACS Publications journals.

ACS Publications Signs DORA

Effective February 2021, ACS Publications has signed the Declaration on Research Assessment (DORA). This demonstrates our commitment as a publisher and professional organization to support broader assessment of research output.

DORA recognizes the need to improve the ways in which the outputs of scholarly research are evaluated. The declaration was developed in 2012 during the Annual Meeting of the American Society for Cell Biology in San Francisco. It has become a worldwide initiative covering all scholarly disciplines and all key stakeholders including funders, publishers, professional societies, institutions, and researchers. DORA’s vision is to advance practical and robust approaches to research assessment globally and across all scholarly disciplines.

“The measurement and assessment of research is a challenge for the entire academic research community,” says Sybille Geisenheyner, Director of Open Science Strategy & Licensing at ACS. “Working together on how to assess the impact and quality of research is one of our main drivers in signing this declaration.”

ACS Publications is dedicated to making meaningful progress toward implementing the five DORA guidelines for publishers. We already fulfill a number of these recommendations, such as encouraging responsible authorship practices, and exploring a broader range of metrics to display the wider impact of articles published by ACS. Most recently, we made the reference list for all ACS Publications research articles open and available via CrossRef.

Read the full DORA here.

Medicinal Chemistry Journals Welcome New Associate Editors

The Journal of Medicinal Chemistry (JMC) and ACS Medicinal Chemistry Letters (ACS MCL) are thrilled to welcome a new cohort of Associate Editors to their respective editorial teams. To welcome them, we asked each new Associate Editor why they’re excited to be a part of their journal’s team. Read below to get to know them!

New Journal of Medicinal Chemistry Associate Editors

James Barrow, Lieber Institute for Brain Development and Johns Hopkins University

“I am thrilled to join the JMC editorial board because it is the premier journal in the field, and I want to help even further raise its stature. Medicinal chemistry is driving exciting advances in medicine, not only by the new compounds prepared, but also new methodology to quickly prepare and evaluate high quality candidates.”

Kelly Chibale, University of Cape Town

“I am excited to join JMC as an Editor for two reasons. First, this gives me a platform to serve the community. Second, this provides me with an opportunity to contribute to sustaining what is excellent about JMC while also being an agent of change towards making JMC more than a place to publish but a place to learn about integrated drug discovery. In doing so it is my hope that authors will have the best possible experience regardless of the decision made on their manuscript’.”

Stefan Laufer, University of Tübingen

“I’m highly excited about my new appointment as medicinal chemistry brings chemical science to the patient, and JMC is at the cutting edge here!”

New ACS Medicinal Chemistry Letters Associate Editors

Jeff Aubé, UNC Chapel Hill

“I’ve always loved the ‘literary’ aspects of science, both as an element of our culture and as an essential step in the scientific method. I am deeply honored by this chance to serve our community.”

Maria Jesus Blanco, Sage Therapeutics

“I am passionate about medicinal chemistry and drug discovery, in particular CNS disorders. As an Associate Editor for ACS MCL, I want to increase the visibility of the field, highlighting innovation in medicinal chemistry towards clinical translation to help patients and their families.”

5 Reasons to Try ACS Author Lab

At ACS Publications, we want to support our researcher community and provide tools to help you publish your research. That’s why we have developed a training course to sharpen your authorship skills. ACS Author Lab is an online training course that helps authors to prepare and submit strong manuscripts, speeding up the publication process.

Here are five reasons you should try ACS Author Lab today:

Expert input – ACS Author Lab was developed by ACS Editors and ACS Publications staff to help authors identify key considerations for each step of preparing and publishing a manuscript.

Flexible pacing – The course consists of seven interactive, self-paced modules, each taking approximately 15-20 minutes to complete, all available whenever you want.

Multi-media content – Modules contain narrated presentations, brief videos, feedback from ACS journal editors, real-world examples from published articles, and knowledge checks that highlight key information.

Checklists are available for download, providing continued access to valuable and relevant tips and tricks.

Certificate of completion – Graduates of ACS Author Lab receive a certificate of completion that can be shared with their network.

ACS Author Lab gives authors an in-depth look at everything they need to know in order to submit a manuscript for publication, with invaluable information for authors at any point in their careers.

The full course is now available to purchase for $50, with ACS Members receiving a 20% discount. Once purchased, access to the course will never expire.

Find out more about ACS Author Lab, including how to sign up for free access to one of our popular modules.

Celebrating African American Chemists: Blanton S. Tolbert

February is Black History Month in the United States. This year, ACS Axial is looking forward and highlighting noteworthy African American chemists working today, engaging them in conversation about their life and work.

Blanton S. Tolbert is a Professor in the Department of Chemistry at Case Western Reserve University.

How would you describe your current area of focus?

I don’t like putting myself in a box, but since it’s required of us sometimes, I would describe myself as a biophysical chemist/structural biologist. Our scientific interest really lies at the interface of trying to understand protein-RNA molecular recognition and how the formation of protein-RNA complexes contribute to gene expression. We pursue that by way of studying RNA and related retroviruses.

How did you become involved with this field? What inspired you?

My Ph.D. was done at the University of Rochester. I had kind of an unusual, I would say, Ph.D. trajectory. I started out in a lab that was doing protein crystallography biophysics, and that lab’s scientific interest was on the ubiquitin-proteosome system. About halfway through my Ph.D. training, my Ph.D. advisor took a position at a different institution. Therefore, I was kind of in this very unfortunate position of having to find a new Ph.D. lab to go and finish my training, or leave the program altogether or go to another university.

I ended up switching to a lab where the focus was on RNA thermodynamics and structural biology. At the time, it seemed like, ‘Oh man, any Ph.D. student would hate for something like this to ever happen.’ But it was probably one of the most fortuitous things to happen because it got me thinking about protein and RNA. I knew then that I kind of wanted to try and combine these two areas in my own lab.

Once I left my Ph.D., I ended up doing a postdoc with Michael Summers at the University of Maryland, Baltimore County. And his lab really focused on the structural biology of RNA viruses, HIV in particular, and MLV, Moloney leukemia virus. That’s where I developed the interest in virology. But the scientific approach that we take to that in my own lab, I could trace back to working in those very two different labs as a Ph.D. student. If it wasn’t for my initial Ph.D. advisor leaving the institution, I probably would’ve ended up on a completely different path.

Could you dig a little bit more into what that period was like for you? How did you decide what the next step for you was going to look like?

I talk about this a lot with my own students and students in general because the Ph.D. process can be daunting and challenging when it’s smooth, and you end up in one lab, and you finish in that lab. That in itself can be challenging because there are ups and downs with experiments, and that goes on.

That period, in particular for me, was quite tough. I’ll be honest with you. When it first happened, there were many thoughts that were racing through my mind. I considered just leaving the Ph.D. program altogether, maybe going to pursue an MBA. I considered maybe law school could be an option, or even just trying to find a new Ph.D. program altogether at a different institution to enroll in.

I’m very fortunate to have worked for some really just great, in my opinion, mentors. The guy who I started my Ph.D. with sat me down and said, ‘Blanton, you have a knack for this. You have a passion; you’re good at it. I can help you find another lab to join,’ knowing my interests, which at the time was really basic science and molecular recognition, how molecules interact with each other. It’s still my passion today. He helped me identify the lab that I ended up finishing my Ph.D. in. So really, he played a key role in helping me make that transition.

But I wanted to have some publications from my initial lab to verify that I worked for this guy. So there’s about a period of six months where I literally worked in that lab alone after he left to take his new position. The lab was kind of small. There was a student who had just joined, so that person found another home rather easily. There was another student who was in his sixth year, who was pretty much just writing their dissertation from home, and then there was me. And there may have been a technician or two who had left. So, for about six months, I had to go into the lab every morning, open it up, run my experiments, collect my data, close the lab down at night, go home and analyze the data and communicate with him via email.

It was in that six-month period that I had to learn to be independent as a graduate student. I think it benefitted me, in the long run, to be quite honest. It’s not something that I would ever encourage that someone would have to go through, but for me, personally, it gave me a sense of self-confidence, and it also demonstrated to me that, ‘Hey I can do this on my own.’

I imagine it eventually made setting up your own lab a little easier.

It did, in many ways, because you don’t gain a lot of experience when everything works out exactly the way it should. I got that experience kind of early in the process. And now it’s an interesting story that I share with people, particularly because the Ph.D. is not easy, and I like to communicate to people my own story, so they get an idea that, ‘hey you know, you can get through these things for sure.’

You mention not wanting to be put in a box, scientifically speaking. How do you fight that? How do you keep your work fresh for yourself?

For me, personally, I pursue what my interests are. I had to sort of make that pivot and now start working on RNA, which I had never really thought about. When I joined the Ph.D. program, I was very much protein-centric. I wanted to do protein structural biology; that’s all I cared about. I didn’t even really care about the general area. It could’ve been cancer, immunology; I just wanted to do protein-centric structural biology. So, when I had to make that pivot and start thinking about RNA, I started really thinking about protein RNA recognition. That’s where my passions are to this day. I think it’s fascinating to think about how molecules find themselves in a complex environment like the cell, right? And make sure they’re forming the right type of interaction to regulate biology.

And so, to answer your question, I stay fresh and avoid putting myself in a box because I pursue the questions that I’m interested in. I let the biology determine what techniques we use, who we collaborate with, and where we end up. I’m very much a question-based person, as opposed to a technique-based person, as opposed to, let’s say, ‘I’m a chemical biologist, and I want to design small molecules to do x, y, and z.’ That’s not me; I’m really interested in biological questions. I figure out, ‘OK, so, how can I put together the right set of people, the right set of experiments, so that we can carve out the answers to those types of questions?’

STEM is still a field where African Americans are underrepresented. What do you think needs to change in order to address that?

There are a number of things, to be quite frank, that need to change. I think one of the things, for sure, is we need more examples of people who have gone on to be successful. That is very powerful, the ability to identify with someone who has been successful at the end of the STEM pipeline. That, in many ways, is how a lot of underrepresented minorities fall out of the pipeline. I think that having more examples of people who have struggled with the pipeline but who have figured out strategies and mechanisms on how to be successful and they are willing to share some of that advice will be a part of that solution.

I also think that part of the solution is just for people in general, to just see each other as individuals and not by our ethnicities and the color of our skin, right? We want to, you know, get to know a person on an individual basis and start to develop relationships with those people. I think that’s going to be a key component.

Then the other thing it kind of relates to is, how do you identify talent? How do you evaluate talent? The metrics for evaluating talent in many ways need to be broadened, reconsidered, or expanded. I think those are some things that are actually within reach, they don’t take a whole lot of effort, and that would make a difference.

When you talk about evaluating talent, are you talking about standardized testing? Are you talking about mentorship?

Looking beyond the number, looking beyond the score. One of the things that I personally do when accepting students in my lab, this might sound bad, but I really don’t place a lot of emphasis on what the person’s academic background or track record may have been.

What I try to do, as much as possible, is get a feeling for their motivation, their interests, their leadership abilities, their abilities to work in a team environment. I use those types of characteristics of what we would probably call soft factors to figure out if the person will be a good fit for my research group. I think that when we stick to these formulas, which are largely driven by how many papers, or how many citations, or x, y, and z, then you might miss some very innovative and creative and sharp individuals because the metric is just too narrow.

I’ve thought about why that isn’t adopted more broadly, and I don’t have a really good explanation for it. In part, I think it’s easy because all of us can count, right? So it’s easier to just look at numbers and say this person will be successful or not. But it also, in many ways, just doesn’t require a lot of effort. To do what I’m suggesting requires you to spend a little more time and to try to get to know the individual, and so I think that plays into it as well.

What’s the piece of advice that you wish you’d received before you started your career in chemistry?

I’ve been asked this question recently over the past year a couple of times now, and there are many different things that I would have probably advised my graduate student self on, based off of where I am now and what I know. But I think the singular most important piece of advice to me would’ve been to say, ‘There’s this concept that’s known as impostor syndrome, and we all experience it, and we may not actually be comfortable with admitting it or saying it.’ But to actually understand that impostor syndrome is a complicated dynamic. You, as an individual, have to know what your values are, what your contributions are, and know that you deserve to be there and that you can be successful. I would say, ‘Look at impostor syndrome head on’ and say, ‘This is a complete waste of physical and mental energy and that I need to stay focused on what my goals are.’ And let that be the motivation to get me through whatever challenges I might face along the way.

Who were the chemists that have inspired you? Past or present?

I’ve really been inspired by a number of scientists for different reasons, some of them just by their approach to things. Linus Pauling, when I first learned about him. He received two Noble Prizes, in chemistry and the peace prize. I was blown away by that. Just because we don’t see a lot of scientists who have that demonstrated range of thought or, let’s say, motivations or interests. So he was a big inspiration to me.

Other scientists that have inspired me are ones that I looked at, and I thought they had a similar cultural experience as mine. Early on, as I was even considering biophysics, I was trying to search and see, ‘OK are there any Black biophysicists out there, some people I can actually learn about?’

Steve Mayo at Caltech, was definitely one of the people who just stood out. He was a leader and still is, and a pioneer at the time. For me, he was quite an inspiration. I don’t think he knows this; I mean, we don’t know each other, but definitely, he was someone that I could look to and say, ‘This is an example of someone who at least looks like me who has gone on to be very successful.’ So, I must be able to do this. I just need to figure out how.

What do you wish I’d have asked you?

I don’t know. Maybe a little bit about my background?

What should people know about your background?

I’m from a small town in South Carolina; the name of the town is Greenwood. The town has about 25,000-28,000 people. There are a lot of interesting things about being from the south, being Black, being from a very small town. I would not have imagined, growing up in my town, that I would end up where I am today – running a research lab and training people from all over the world. I look back on that, and I’m like, ‘That’s really cool.’

I had a very good family foundation. I’m the youngest of 3. My older brother is a physician, a medical doctor. My sister is a middle school principal; she has her EDD. And my father is deceased, but he was a minister. My mother has her doctorate in theology. And so, I was, to be quite honest, lucky to be born into this sort of nuclear family that put a lot of emphasis on education.

And I had personal role models. Number one, my first role model in my early life was my older brother, seven years older than me. And I think that really gave me a lot of encouragement and a lot of confidence that you can be successful. Even coming from this small town like I did. That’s one of the things I like to share with people. My background is very important to me. Where I came from is very important to me because it established my values system.

Read Blanton S. Tolbert’s papers in ACS Publications journals.