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Announcing the Launch of ACS Publications’ Data Availability Statement Pilot at The Journal of Organic Chemistry, Organic Letters, and ACS Organic & Inorganic Au

ACS Publications is excited to announce the launch of a Data Availability Statement pilot at The Journal of Organic Chemistry, Organic Letters, and ACS Organic & Inorganic Au effective September 15, 2022. These journals will now require each peer-reviewed article to feature a Data Availability Statement and will achieve Level 2 in the ACS Research Data Policy—which encourages authors to publicly share all the data underlying the results reported in the article, preferably via archiving in an appropriate publicly available repository.

As the value of data from scientific research increases, so does the need for higher levels of visibility into the data sources involved in concluding the scientific results. In addition to increasing trust in the research findings, having findable, readable, and reusable data boosts the impact of the research and the associated publications. In addition, data sharing and data citation align with growing funder mandates on reporting data.

“The amount of data in organic chemistry has grown exponentially over the past years. Therefore, access to these data is imperative to maintain high quality in offering increased validation of the research by organic chemists and other scientists”, says Géraldine Masson, Deputy Editor, ACS Organic & Inorganic Au. She also suggests when preparing a Data Availability Statement, it’s important that “the authors confirm that the data supporting the findings of this study are available within the article [and/or] its supplementary materials. Authors are also required to provide a Data Availability Statement describing the public availability of the data underlying the conclusions drawn in the research article and provide a means of access, where applicable, by linking to the data, preferably through the use of a persistent identifier such as a DOI or an Accession Number assigned by a data repository”.

Submitting Your Article to a Pilot Journal

Starting on September 15, 2022, authors of The Journal of Organic Chemistry, Organic Letters, and ACS Organic & Inorganic Au will now be required to include a Data Availability Statement for all peer-reviewed articles. As part of the pilot, authors will have a new custom question at submission asking when the Data Availability Statement will be provided (Figure 1).

Figure 1: New Custom Question in ACS Paragon Plus
Figure 1: New Custom Question in ACS Paragon Plus

This statement can be included during manuscript submission or during the revision process, but all articles must have a Data Availability Statement prior to acceptance. This statement should be selected from a prewritten set (Figure 2) or can be combined if multiple statements apply and customized as needed.

Figure 2: ACS Data Availability Statements
Figure 2: ACS Data Availability Statements

Data Availability Statements should include confirmation that the data underlying the publication exists and specify where the data can be found, all persistent identifiers (Accession Numbers, DOIs, or URLs), and any relevant information on licensing restrictions. As a result, “Data is available upon request” will no longer qualify as a Data Availability Statement. ACS also encourages the deposition of data in open repositories. Authors may refer to and for information on available repositories, their certification status, and services offered.

Within the published article, the Data Availability Statement will be a standalone piece of text presented in the Associated Content section (Figure 3).

Figure 3: Sample Data Availability Statement
Figure 3: Sample Data Availability Statement

Building and Supporting Trust in Research

These are the critical steps that The Journal of Organic Chemistry, Organic Letters, ACS Organic & Inorganic Au, and ACS Publications are taking to build on our commitment to embracing the future of open science and maintaining ACS Publications’ positioning as the “Most Trusted. Most Cited. Most Read.”

Read the full editorial on the ACS Data Availability Statement Pilot.

For more information, view the FAQ section on Data Availability Statements.

White Teeth Without the Toothbrush

This article is based on a recent paper published in ACS Applied Materials & Interfaces, “Fast Cross-Linked Hydrogel as a Green Light-Activated Photocatalyst for Localized Biofilm Disruption and Brush-Free Tooth Whitening.”

Read the full paper here

It’s not just a cliché that the first thing people notice about you is your smile: a 2010 survey found nearly half of us choose a great smile as a person’s most attractive feature.1 Furthermore, aspects of oral hygiene such as bad breath (89%) and yellow teeth (79%) took the lead for major turn-offs.1 Is there a chemistry solution for this very human problem?  

Globally, around 3.5 billion people suffer from oral diseases such as tooth decay and gum disease,2 many of which can be prevented through good oral hygiene. But traditional toothpastes remove only surface stains, and bleaching treatments can harm enamel. New research published in ACS Applied Materials & Interfaces reports on a novel hydrogel treatment that can break apart cavity-forming biofilms and whiten teeth without damage.

Current whitening treatments combine hydrogen peroxide gels with blue light, producing a chemical reaction that removes stains but also generates reactive oxygen species that can break down enamel and potentially damage exposed skin and eyes. Researchers at Nanchang University in China wanted to find a material that could instead be activated by a safer green light to both whiten teeth and prevent cavities.

The research team designed an injectable sodium alginate hydrogel membrane doped with bismuth oxychloride and cubic cuprous oxide nanoparticles to simultaneously achieve local tooth whitening and biofilm removal through a photodynamic dental therapy process.3 This was tested ex vivo on teeth stained with coffee, tea, blueberry juice, and soy sauce. Following treatment with the hydrogel and green light, teeth got brighter over time with no damage to the enamel. Additionally, the treatment killed 94% of bacteria in biofilms.

To demonstrate efficacy in vivo, the team used the new method on mice whose mouths were inoculated with cavity-forming bacteria, and they found that the new method prevented both moderate and deep cavities forming on tooth surfaces. The researchers report that their safe, brush-free treatment both effectively prevents cavities and whitens teeth, demonstrating a promising strategy for oral health care in the future.3 

Watch the video around this research created by the ACS Science Communications team:

Read the full press release on

Read the original article from ACS Applied Materials & Interfaces


  1. Philips Sonicare Survey. Oral Care Love Affair: Americans Open up About Their Oral Health. 6 December 2010.
  2. World Health Organization. Oral Health Fact Sheet. 15 March 2022.
  3. Li Q, et al. Fast Cross-Linked Hydrogel as a Green Light-Activated Photocatalyst for Localized Biofilm Disruption and Brush-Free Tooth Whitening. ACS Appl Mater Interfaces 2022;14(25):28427–28438.

Further reading on this topic

Article icon

A safe and effective way to whiten teeth
American Chemical Society. Press Release. 18 July 2018

Article icon

Photothermal-Enhanced Fenton-like Catalytic Activity of Oxygen-Deficient Nanotitania for Efficient and Safe Tooth Whitening
Xingyu Hu, Li Xie, Zhaoyu Xu, Suru Liu, Xinzhi Tan, Ruojing Qian, Ruitao Zhang, Mingyan Jiang, Wenjia Xie, and Weidong Tian
DOI: 10.1021/acsami.1c06774

Huimin Zhao Named the New Editor-in-Chief of ACS Synthetic Biology

Huimin Zhao, professor of chemical & biomolecular engineering

ACS Publications is pleased to introduce Dr. Huimin Zhao as the new Editor-in-Chief of ACS Synthetic Biology. Dr. Zhao is the Steven L. Miller Chair of chemical and biomolecular engineering at the University of Illinois at Urbana-Champaign (UIUC) and director of NSF AI Research Institute for Molecule Synthesis.

Dr. Zhao received his B.S. degree in Biology from the University of Science and Technology of China in 1992 and his Ph.D. degree in Chemistry from the California Institute of Technology in 1998 under the guidance of Nobel Laureate Dr. Frances Arnold. Prior to joining UIUC in 2000, he was a project leader at the Industrial Biotechnology Laboratory of the Dow Chemical Company.

Dr. Zhao has authored and co-authored over 380 research articles and over 30 issued and pending patent applications with several being licensed by industry. Dr. Zhao received numerous research and teaching awards and honors such as the ECI Enzyme Engineering Award (2019), the Marvin Johnson Award (2018), and the Charles Thom Award (2016). His primary research interests are in the development and applications of synthetic biology, machine learning, and laboratory automation tools to address society’s most daunting challenges in health, energy, and sustainability.

“Advances in synthetic biology are needed more than ever, as the world seeks solutions to improve human health, mitigate climate change and reduce environmental waste,” says Dr. Zhao. “I am excited to lead the world-renowned journal ACS Synthetic Biology, particularly as the field enters an exponential growth phase that has attracted numerous researchers, government funding and private sector interest.”

I had the pleasure of connecting with Dr. Zhao in this recent interview. Learn more about his background in synthetic biology, machine learning, his vision for the journal, and more below.

What are you currently working on?

My group is currently developing new tools of synthetic biology, artificial intelligence/machine learning (AI/ML), and laboratory automation for biosystems design with a goal of making biology easier to engineer and understand. Particularly, my group is interested in developing AI/ML-enabled closed design-build-test-learn loops for protein engineering and metabolic engineering. In addition, my group is interested in engineering microbial cell factories for the production of chemicals and materials, activating silent natural product biosynthetic gene clusters for the discovery of novel bioactive compounds, and developing new synthetic biology tools for health care.

What element has been most central to your scientific career, and why?

A passion for science. Research is a long and arduous process that is full of uncertainty and failure. Many young people who are initially enthusiastic about science decide to quit their scientific careers mainly because of this lengthy process of doing research. However, I love the thrill of discovery and don’t mind lengthy or even repetitive processes. Like most scientists, I also had many ups and downs in my scientific career, but what kept me motivated in this long and sometimes lonely journey is my passion for science. There are simply so many interesting scientific problems awaiting to be solved.

What opportunities in your field excite you the most?

Synthetic biology is entering an exponential growth phase. With the rapid advances of DNA/RNA technologies (reading, writing, and editing), AI/ML, and automation, biology is indeed becoming easier to engineer and understand than ever, which has created numerous new opportunities in basic and applied biological research and medicine. Synthetic biology has been regarded as one of the most important enabling technologies in the rapidly growing bioeconomy. I expect there will be more integration of synthetic biology, AI/ML, and automation in the future, which will also lead to a new data-driven research paradigm.

What do you hope to bring to the journal as Editor-in-Chief?

My own scientific career parallels the growth of the synthetic biology field and I see many more growth opportunities in the synthetic biology field in the coming years. What I hope to bring to the journal as Editor-in-Chief is to make ACS Synthetic Biology the go-to publication venue for all fields of synthetic biology and biological systems and use ACS Synthetic Biology as a vehicle to lead the growth of the synthetic biology field. I believe that to a large extent, a journal’s strength depends on the strength of the research field/discipline it covers. Fortunately, synthetic biology is a rapidly growing field that has attracted numerous researchers, government funding agencies, and private sectors. So, I think ACS Synthetic Biology is well-positioned to move up to the next level.

Explore Dr. Zhao’s recent work in the journal today.

Learn More About ACS Synthetic Biology.

3 Reasons to Direct Transfer Your Manuscript from bioRxiv to an ACS Journal

The Editors and staff at ACS Publications, a nonprofit publisher and division of the American Chemical Society, are proud to announce that 12 of the peer-reviewed journals in our biological portfolio are accepting direct transfers of manuscripts and metadata from bioRxiv as of Monday, June 6, 2022.

If you already publish your findings in our journals, we hope this will make that process even easier for you! If you haven’t published in an ACS biological journal recently—or ever—we bet you’ve read one of our articles on PubMed Central or Google Scholar, and hope you’ll read on to learn more.


3 Reasons to Publish Your Biological Paper in an ACS Publications Journal

1. ACS Publications is a nonprofit society publisher and a division of the American Chemical Society.

ACS Publications is an experienced publisher with a focus on serving researchers and the scientific community. We do this by:

  • Enlisting practicing researchers from prominent institutions around the world to serve as Editors-in-Chief and other members of our journals’ editorial teams.
  • Employing a high-quality peer-review process developed over more than 140 years of publishing respected scholarly journals.
  • Expediting manuscript processing to deliver decisions and get papers published as quickly as possible.


2. ACS has more than 60 years of experience publishing high-quality biological journals.

ACS expanded our engagement with the global community of scientific researchers more than a half century ago. Now we have more than a dozen core biological journals as well as more than 20 multidisciplinary journals and those focused on branches of chemistry that also publish articles about biological research.


3. ACS offers authors a variety of publishing options.

Authors who publish with ACS can choose to publish in a hybrid, Plan S-compliant Transformative Journal or in a fully open access journal.

  • Most ACS journals are Transformative Journals, which offer a choice of publishing under the traditional subscription model or under the newer open access model:
    • It’s free to submit and free to publish in an ACS Transformative Journal under the traditional subscription model. That means no author charges, page charges, processing charges or color charges.
    • Once an article is accepted for publication in an ACS Transformative Journal, authors who want to make their article open access—or are required to by their funders—can do so by paying an article publishing charge (APC).
  • ACS also has 12 fully open access journals, including ACS Bio & Med Chem Au, which serves the biological research community. Publishing in these journals also requires paying an APC after article acceptance.


Get to Know ACS Publications’ Biological Journals

The 12 journals listed below began accepting direct transfers of manuscripts and metadata from bioRxiv on Monday, June 6, 2022. Read on to learn more about these journals or visit to learn about all the full portfolio of ACS journals.

Journal of Medicinal Chemistry
In publication since 1959
Findings on the relationship between molecular structure and biological activity or mode of action in drug discovery and development.
Impact Factor 2021: 8.039 | Citations 2021: 92,468| CiteScore 2021: 11.5
If you have questions about this journal, please send them to

In publication since 1962.
Exceptional, rigorous, high-impact interdisciplinary research articles across all of biological chemistry.
Impact Factor 2021: 3.321 | Citations 2021: 76,644| CiteScore 2021: 6.2
If you have questions about this journal, please send them to

Journal of Natural Products
In publication since 1979
Reports on natural products related to the chemistry or biochemistry of naturally occurring compounds or the biology of their living systems and environments.
Impact Factor 2021: 4.803 | Citations 2021: 34,341| CiteScore 2021: 7.1
If you have questions about this journal, please send them to

Bioconjugate Chemistry
In publication since 1990
Research articles on all aspects of bioconjugates, including the preparation, properties and applications of biomolecular conjugates.
Impact Factor 2021: 6.069 | Citations 2021: 19,624| CiteScore 2021: 9.4
If you have questions about this journal, please send them to

Molecular Pharmaceutics
In publication since 2004
Findings that contribute to the molecular mechanistic understanding of drug delivery and drug delivery systems.
Impact Factor 2021: 5.364 | Citations 2021: 24,761| CiteScore 2021: 9.2
If you have questions about this journal, please send them to

ACS Chemical Biology
In publication since 2006
Reports of research on cellular processes using in vitro, cellular or whole organism studies at the chemical and biological interface.
Impact Factor 2021: 4.634 | Citations 2021: 17,285| CiteScore 2021: 8.6
If you have questions about this journal, please send them to

ACS Chemical Neuroscience
In publication since 2010
Chemical, quantitative biological, biophysical, and bioengineering research reports on the nervous system and neurological disorders.
Impact Factor 2021: 5.780 | Citations 2021: 12,168| CiteScore 2021: 7.7
If you have questions about this journal, please send them to

ACS Medicinal Chemistry Letters
In publication since 2010
New findings in drug discovery, compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology.
Impact Factor 2021: 4.632 | Citations 2021: 9,499| CiteScore 2021: 6.6
If you have questions about this journal, please send them to

ACS Synthetic Biology
In publication since 2012
Reports on integrative, molecular approaches to the understanding of the organization and function of cells, tissues, and organisms in systems.
Impact Factor 2021: 5.249 | Citations 2021: 9,413| CiteScore 2021: 8.3
If you have questions about this journal, please send them to

ACS Infectious Diseases
In publication since 2015
Highlights the role of chemistry in the multidisciplinary and collaborative field of infectious diseases.
Impact Factor 2021: 5.578 | Citations 2021: 5,660| CiteScore 2021: 7.7
If you have questions about this journal, please send them to

ACS Pharmacology & Translational Science
In publication since 2018
A biomedical journal reporting advances across the molecular and biological sciences—from basic and preclinical studies to clinical trials.
If you have questions about this journal, please send them to

ACS Bio & Med Chem Au
In publication since 2021
Biological and medicinal chemistry covering the chemical, physical, biological, mechanistic, and structural basis of biological function.
If you have questions about this journal, please send them to

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Call for Papers: Data Science for Advancing Environmental Science, Engineering, and Technology

There are many environmentally relevant research areas where advances in data science including machine learning (ML) and artificial intelligence (AI) have been applied to large datasets to better decipher the complex relationships between system variables and system behaviors, leading to new insights on solution development. 

This joint call for papers by Environmental Science & Technology and Environmental Science & Technology Letters seeks contributions on ML and AI research studies in environmental areas that demonstrate the great potential of these approaches to improve, for example, our understanding of natural and engineered environmental systems, towards maintaining a healthy ecosystem, and/or building a circular economy.

Papers are desired that include either novel applications of data science/ML methodologies and approaches adapted for use in environmental datasets, or address knowledge gaps in an important environmental science and technology that were not approachable using standard analysis tools.

Submissions to the Special Issue should demonstrate the “value added” of taking a ML or AI approach over existing approaches.  Submissions should also ensure that the datasets are large and complex enough that ML approaches are necessary and robust, and researchers must go beyond the “black box” of simple agnostic applications of existing algorithms to determine the “best one”. Papers should ideally also allow insights into mechanistic underpinnings of the system being investigated.

To serve as model examples of ML and AI analyses on complex environmental datasets, papers must facilitate reproducibility by adhering to FAIR data principles and demonstrate computational rigor (e.g., discuss model assumptions/limitations, data considerations, cross validation, model performance), and provide ML and AI models and datasets to readers through publicly available data repositories.

Submit your manuscript


Greg Lowry, Executive Editor, Environmental Science & Technology

Alexandria Boehm, Associate Editor, Environmental Science & Technology and Environmental Science & Technology Letters

Bryan W. Brooks, Editor-in-Chief, Environmental Science & Technology Letters

Pablo Gago-Ferrero, Topic Editor, Environmental Science & Technology

Guibin Jiang, Associate Editor, Environmental Science & Technology

Gerrad Jones, Topic Editor, Environmental Science & Technology

Qian Liu, Guest Editor

Z. Jason Ren, Topic Editor, Environmental Science & Technology and Environmental Science & Technology Letters

Shuxiao Wang, Associate Editor, Environmental Science & Technology  and Environmental Science & Technology Letters

Julie Zimmerman, Editor-in-Chief, Environmental Science & Technology


Author Instructions:

To submit your manuscript, please visit the Environmental Science & Technology or Environmental Science & Technology Letters website. Please follow the normal procedures for manuscript submission and when in the ACS Paragon Plus submission site, select the special issue of Data Science for Advancing Environmental Science, Engineering, and Technology.” All manuscripts will undergo rigorous peer review. For additional submission instructions, please see the Environmental Science & Technology Author Guidelines or the Environmental Science & Technology Letters Author Guidelines.

The deadline for submissions is January 12, 2023.

Expanding ACS’ Diversity & Inclusion Cover Art Series in 2022

In February 2021, Analytical Chemistry published the first edition of its Diversity & Inclusion Cover Art Series. The cover featured Dr. Jeanita Pritchett’s original painting of a young girl standing in front of a mirror, seeing herself as a “grown up” chemist; she penned an accompanying Editorial that featured the details of her story. Since this initial publication, ACS Publications continues to be amazed by the wonderful contributions to this series and the positive reactions that have resonated from the community. Analytical Chemistry published 9 more covers in 2021, and the journal is excited to continue this monthly series in 2022.

This Analytical Chemistry Editorial from last year highlighted the importance ACS Publications places on using our publishing platform to amplify marginalized voices and recognize historically excluded or under-recognized populations of chemists. ACS Publications is pleased to announce that our other journal Editors share this sentiment and will expand the series to each of their journals for one issue in 2022. You are invited and encouraged to submit your own cover to the ACS journal of your choosing, helping to amplify the visibility of underrepresented chemists in our communities.

Submission Details:

ACS journals are soliciting authors who are underrepresented in the chemistry community (most notably those who identify as BIPOC, LGBTQ, first generation, and those with disabilities) to submit their cover art. Each participating journal issue front cover will feature the artist’s artwork, as well as an editorial written by the artist describing their artwork and story. Artists need not be chemists, but the work and editorial should have a connection to the field of chemistry. ACS hopes this initiative serves as another one way to foster an inclusive environment in which underrepresented cohorts in the chemistry community can strengthen their voice through their artwork and written word.

If selected, artists will be compensated $1000 USD.* ACS Publications may select some cover art be featured on ACS store products; in this case, additional compensation will be provided.

If you are interested in contributing to this initiative, please submit the following:

  • An initial sketch of your artwork; the sketch should clearly communicate the diversity and inclusion theme.
  • A paragraph describing the cover art idea and its meaning to you.
  • Top 3-5 preferred journal(s) in which you would like your artwork and editorial to appear. We will do our best to accommodate your preferences.

If your initial sketch is selected for this program, you will be asked to provide:

  • Completed artwork that can be digitized to 8.19 x 10.0 inches with a resolution of 300 dpi or higher, preferably in the .jpg or .tif format. The cover art must include 2 inches of space to accommodate the journal logo.
  • A short editorial describing your story and your artwork (roughly 400­-800 words).

ACS Publications will consider artwork submissions on a rolling basis until Sept 30, 2022. Please note that ACS Publications will compile and promote all published covers in an end-of-year collection.

Submit your artwork now!

See previous covers and editorials from this program.

*Please note cover art under this program will not be tied to a research article. It is the responsibility of the individual to ensure they can accept outside forms of payment from ACS.

If you have any questions, please email:

2021 in Biochemistry Perspectives

Biochemistry Perspectives are designed to communicate a focused review of the most exciting new developments in a field or area and with an eye toward guiding future research.

Explore the Perspectives published in Biochemistry over the past year:

Antibodies from Lampreys as Smart Anti-Glycan Reagents (SAGRs): Perspectives on Their Specificity, Structure, and Glyco-genomics
Tanya R. McKitrickTanya R. McKitrick, Deniz Eris, Nandini Mondal, Rajindra P. Aryal, Nathanael McCurley, Jamie Heimburg-Molinaro, and Richard D. Cummings
DOI: 10.1021/acs.biochem.9b01015
Tafenoquine: A Step toward Malaria Elimination
Kuan-Yi Lu and Emily R. Derbyshire
DOI: 10.1021/acs.biochem.9b01105
The Biochemistry of Survival Motor Neuron Protein Is Paving the Way to Novel Therapies for Spinal Muscle Atrophy
Patrick Lomonte, Faouzi Baklouti, and Olivier Binda
DOI: 10.1021/acs.biochem.9b01124
mRNA Therapies: New Hope in the Fight against Melanoma
Melissa van Dülmen and Andrea Rentmeister
DOI: 10.1021/acs.biochem.0c00181
Mimicking Functions of Native Enzymes or Photosynthetic Reaction Centers by Nucleoapzymes and Photonucleoapzymes
Margarita Vázquez-González, Zhixin Zhou, Yonatan Biniuri, Bilha Willner, and Itamar Willner
DOI: 10.1021/acs.biochem.0c00421
Light-Driven Catalytic Regulation of Enzymes at the Interface with Plasmonic Nanomaterials
Heloise Ribeiro de Barros, Fernando López-Gallego*, and Luis M. Liz-Marzán
DOI: 10.1021/acs.biochem.0c00447
Hepatocellular Carcinoma and Statins
Ghazal Alipour Talesh, Véronique Trézéguet*, and Aksam Merched
DOI: 10.1021/acs.biochem.0c00476
Specificity Distorted: Chemical Induction of Biological Paracatalysis
Brian P. Callahan, Daniel A. Ciulla, Andrew G. Wagner, Zihan Xu, and Xiaoyu Zhang
DOI: 10.1021/acs.biochem.0c00643
Targeting Lipid Metabolism in Liver Cancer
Malak Alannan, Hussein Fayyad-Kazan, Véronique Trézéguet, and Aksam Merched
DOI: 10.1021/acs.biochem.0c00477
Illuminating the Path to Target GPCR Structures and Functions
Christian D.-T. Nielsen, Divya Dhasmana, Giuseppe Floresta, Thorsten Wohland, and Agostino Cilibrizzi
DOI: 10.1021/acs.biochem.0c00606
The Origin of Lipid Rafts
Steven L. Regen
DOI: 10.1021/acs.biochem.0c00851
Disulfide Bridging Strategies in Viral and Nonviral Platforms for Nucleic Acid Delivery
Kingshuk Dutta, Ritam Das, Jewel Medeiros, and S. Thayumanavan
DOI: 10.1021/acs.biochem.0c00860
Early Strides in NMR Dynamics Measurements
Jane Dyson
DOI: 10.1021/acs.biochem.1c00141
Buffers, Especially the Good Kind
Gary J. Pielak
DOI: 10.1021/acs.biochem.1c00200
Evolution of Enzyme Function and the Development of Catalytic Efficiency: Triosephosphate Isomerase, Jeremy R. Knowles, and W. John Albery
John A. Gerlt
DOI: 10.1021/acs.biochem.1c00211
Long-Acting Cabotegravir for HIV/AIDS Prophylaxis
Kathleen D. Engelman and Alan N. Engelman
DOI: 10.1021/acs.biochem.1c00157
Live and Let Dye
Luke D. Lavis
DOI: 10.1021/acs.biochem.1c00299
Revisiting Nitric Oxide Signaling: Where Was It, and Where Is It Going?
Michael A. Marletta
DOI: 10.1021/acs.biochem.1c00276
Rhodium Complexes Targeting DNA Mismatches as a Basis for New Therapeutics in Cancers Deficient in Mismatch Repair
Adela Nano, Joanne Dai, Julie M. Bailis, and Jacqueline K. Barton
DOI: 10.1021/acs.biochem.1c00302
Hydrogen/Deuterium Exchange and Nuclear Magnetic Resonance Spectroscopy Reveal Dynamic Allostery on Multiple Time Scales in the Serine Protease Thrombin
Riley B. Peacock and Elizabeth A. Komives
DOI: 10.1021/acs.biochem.1c00277
Protein Engineering in the Design of Protein–Protein Interactions: SARS-CoV-2 Inhibitors as a Test Case
Jiří Zahradník and Gideon Schreiber
DOI: 10.1021/acs.biochem.1c00356
Genetic Code Expansion: A Brief History and Perspective
Mia A. Shandell, Zhongping Tan, and Virginia W. Cornish
DOI: 10.1021/acs.biochem.1c00286
Origins of Ca2+ Imaging with Fluorescent Indicators
Xinqi Zhou, Kayla J. Belavek, and Evan W. Miller
DOI: 10.1021/acs.biochem.1c00350
Chance Favors the Perplexed Mind: The Critical Role of Mechanistic Biochemistry in Drug Discovery
Robert A. Copeland
DOI: 10.1021/acs.biochem.1c00345
Mechanisms of O2 Activation by Mononuclear Non-Heme Iron Enzymes
Edward I. Solomon, Dory E. DeWeese, and Jeffrey T. Babicz Jr.
DOI: 10.1021/acs.biochem.1c00370
Correlated Motions in Structural Biology
Da Xu, Steve P. Meisburger, and Nozomi Ando
DOI: 10.1021/acs.biochem.1c00420
Liquid–Liquid Phase Separation in Biology: Specific Stoichiometric Molecular Interactions vs Promiscuous Interactions Mediated by Disordered Sequences
Zhe Feng, Bowen Jia, and Mingjie Zhang
DOI: 10.1021/acs.biochem.1c00376
Inducible Protein Degradation to Understand Genome Architecture
Alexi Tallan and Benjamin Z. Stanton
DOI: 10.1021/acs.biochem.1c00306
Functional Roles of Chelated Magnesium Ions in RNA Folding and Function
Ryota Yamagami, Jacob P. Sieg, and Philip C. Bevilacqua
DOI: 10.1021/acs.biochem.1c00012
Drugging the Undruggable: How Isoquinolines and PKA Initiated the Era of Designed Protein Kinase Inhibitor Therapeutics
Robin Lorenz, Jian Wu, Friedrich W. Herberg, Susan S. Taylor, and Richard A. Engh
DOI: 10.1021/acs.biochem.1c00359
Phase Separation in Cell Polarity
Heyang Wei and Wenyu Wen
DOI: 10.1021/acs.biochem.1c00372
Global Mapping of Metalloproteomes
Xin Zeng, Yao Cheng, and Chu Wang
DOI: 10.1021/acs.biochem.1c00404
Low Intrinsic Efficacy Alone Cannot Explain the Improved Side Effect Profiles of New Opioid Agonists
Edward L. Stahl and Laura M. Bohn
DOI: 10.1021/acs.biochem.1c00466
Ligandability of E3 Ligases for Targeted Protein Degradation Applications
Bridget P. Belcher, Carl C. Ward, and Daniel K. Nomura
DOI: 10.1021/acs.biochem.1c00464
Redefining the Scope of Targeted Protein Degradation: Translational Opportunities in Hijacking the Autophagy–Lysosome Pathway
Katelyn Cassidy and Heng Zhao
DOI: 10.1021/acs.biochem.1c00330
The Birth of Genomic Enzymology: Discovery of the Mechanistically Diverse Enolase Superfamily
Karen N. Allen and Christian P. Whitman
DOI: 10.1021/acs.biochem.1c00494
Ins and Outs: Recent Advancements in Membrane Protein-Mediated Prokaryotic Ferrous Iron Transport
Janae B. Brown, Mark A. Lee, and Aaron T. Smith
DOI: 10.1021/acs.biochem.1c00586
The Moderately (D)efficient Enzyme: Catalysis-Related Damage In Vivo and Its Repair
Ulschan Bathe, Bryan J. Leong, Donald R. McCarty, Christopher S. Henry, Paul E. Abraham, Mark A. Wilson, and Andrew D. Hanson
DOI: 10.1021/acs.biochem.1c00613
Bacterial Responses to Iron Withholding by Calprotectin
Adunoluwa O. Obisesan, Emily M. Zygiel, and Elizabeth M. Nolan
DOI: 10.1021/acs.biochem.1c00572
Reframing the Protein Folding Problem: Entropy as Organizer
George D. Rose
DOI: 10.1021/acs.biochem.1c00687
Toward Elucidating the Human Gut Microbiota–Brain Axis: Molecules, Biochemistry, and Implications for Health and Diseases
Yunjia Lai, Radhika Dhingra, Zhenfa Zhang, Louise M. Ball, Mark J. Zylka, and Kun Lu
DOI: 10.1021/acs.biochem.1c00656
Three Rings to Rule Them All: How Versatile Flavoenzymes Orchestrate the Structural Diversification of Natural Products
Marina Toplak and Robin Teufel
DOI: 10.1021/acs.biochem.1c00763
Chemoproteomic Analysis of Microbiota Metabolite–Protein Targets and Mechanisms
Xiaohui Zhao, Xinglin Yang, and Howard C. Hang
DOI: 10.1021/acs.biochem.1c00758
Protein Engineering in Ribosomally Synthesized and Post-translationally Modified Peptides (RiPPs)
Truc Do and A. James Link
DOI: 10.1021/acs.biochem.1c00714
Biochemistry Perspectives are usually submitted by invitation, but suggestions to the Biochemistry editors of both topics and authors are welcome. Make a suggestion:

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ACS Publications’ Newest Associate Editors: Q4 2021

When a journal adds a new associate editor, that change means more for readers than just a tweak to the masthead. New associate editors bring new experiences, new perspectives, and new ideas to their publications. Get to know some of ACS’s latest editors and learn what unique gifts they’ll be bringing to their respective journals.

Ashutosh Sharma, ACS Applied Materials & Interfaces

What is your research focus? What initially attracted you to your field?

In the last 35 years, my primary focus has been on soft interfaces, colloids, and nanoscale entities and their myriad applications and tech development. These applications have at different times branched into self-organization in nanoscale films; nanofabrication and micro/nano-patterning; wetting, adhesion, and friction; electrospinning of functional materials for devices; carbon and polymeric nanocomposites for environmental remediation, energy storage, and health (theranostics, biosensors) and biomaterials.

When I started on my Ph.D. work back in 1984, the 2-D world of interfaces, such as its thermodynamics and mechanics, was an upcoming, exciting area in chemical engineering with many interesting potential applications. During this time, I initiated work on the pathophysiology of Dry Eye Syndromes in the framework of thin films (tear film) and wetting (cornea), which was a first. Basically, my interest all along has been in connecting different dots of knowledge that seemingly appear to be disjointed. This approach led to many opportunities along the way.

What do you hope to bring to your journal?

ACS Applied Materials and Interfaces is a rather unique, wide spectrum journal in that it covers many deep areas of science together with their important applications, which could aid in the development of real technologies and products. These aspects of ACS AMI fit rather well with my own research background and thinking. While reading a paper, I like to ask several questions: Is there good, reasoned, verifiable science in there? Is there an element of novelty in at least one of these components that I call 4 Ms of Science—mechanics (understanding) or materials or methods, or in the machine/device architecture? Is it a clearly superior application, even if not terribly novel? How profound or incremental are the contents? Is narrative clear and exciting for an average reader in that area? I do think that these elements bring value to any good journal in applied sciences. In particular, I hope to contribute to the editorial work in the areas of colloids, soft interfaces, and their applications and also bring the journal to the greater attention of Indian scientists as an excellent platform to publish their best works with applied flavors.

What are the major challenges facing your field today?

An overarching challenge is a contextually meaningful, synergistic convergence of elements and functionalities in the new materials/interfaces that are engineered to provide solutions to a problem, which is actually a multidimensional problem, as most of the real ones are. For example, miniaturized low-cost autonomous sensor networks (smart pebbles) that seamlessly embed some computing at the edge, communication, machine learning, fault diagnosis, and auto-calibration, positional information, actuators for local actions, and a long-lasting power source that may harness vibrations, solar and other stuff such as surrounding fluids! There would have to be greater integration of the physical, digital, and biological for the new multifunctional materials. Nature-inspired materials and manufacturing is a major opportunity in which we have currently only barely scratched the surface. The most popular examples have been superwetting, smart adhesives, structural colors, fog harvesting, etc. However, interesting materials and manufacturing in nature are not passive, but embed information and the action elements, and most often perform functions by being connected to a larger system of communication and computing! On a lighter note, one could think of progressing from the advanced materials, functional materials, smart materials, etc to informational materials, intelligent materials, wise materials, and who knows, even conscious materials that will inspire a series of CONMAT conferences! Other challenges with functional interfaces are their durability and large-scale production.

What do you think is the most interesting and/or important unsolved problem in your field?

On the most fundamental level, inter-surface and inter-particle interactions are rather poorly understood and predicted, especially for the real physico-chemically heterogeneous interfaces in the aqueous media, including bio- and polymeric surfaces. Such interactions include for example the long-range van der Waals, electrostatic and electrodynamic, acid-base (hydrogen bonding) structural and entropic, specific, etc. Another complexity is summing of these interactions for poorly defined heterogeneous interfaces. A rational understanding and the design of interfaces for most applications demand developing such insights at multiple scales.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Self-Organized Wrinkling in Thin Polymer Films under Solvent–Nonsolvent Solutions: Patterning Strategy for Microfluidic Applications
ACS Appl. Polym. Mater. 2021, 3, 12, 6198–6206
DOI: 10.1021/acsapm.1c01044

Thin polymer coatings show a novel self-organized wrinkling instability on their surface when put under a mixture of a good solvent and a non-solvent. The solvent swells the film and the mixture diffusing to the polymer-substrate interface delaminates the film. Interestingly, along a polygonal network of lines where local detachments occur, thus forming buried micro-channels. The selective delamination-induced wrinkling is found to be a rather generic phenomenon that can be tuned in different polymer films of variable thickness by appropriate combinations of solvent–nonsolvent mixtures. The paper has some of the elements I like: discovering a new phenomenon, understanding its control to produce channels of the desired geometry, and potential applications, e.g., in micropatterning and microfluidics.

Anything else you’d like readers to know about you?

My other areas of interest are philosophy and art. Most of my sketches are made while listening to lectures and in meetings! Paradoxically, it mostly allows a better understanding of what the speaker is saying, owing to shutting down the unrelated internal dialogue. Apparently, the brain cannot fully focus on two streams of thoughts simultaneously!

For about seven years, until August 2021, I was a Secretary to the Government of India heading its Department of Science and Technology, which allowed greater appreciation of how science, technology, and innovation connect with different segments of society and how policies are an important instrument of meeting the challenges and leveraging the opportunities of the future through science and technology.

David Olson, ACS Chemical Neuroscience

What is your research focus? What initially attracted you to your field?

Our lab studies a class of compounds that we call psychoplastogens, or small molecules capable of promoting neural plasticity. Such compounds have enormous potential for treating a wide variety of illnesses including depression, anxiety disorders, addiction, and neurodegenerative diseases.

We use a combination of synthetic chemistry, molecular neurobiology, and behavioral neuropharmacology to 1) understand the fundamental mechanisms underlying the effects of psychoplastogens on the nervous system, and 2) develop next-generation neurotherapeutics. I was initially attracted to the field of central nervous system drug discovery due to the enormous unmet medical need. There are a ton of people who need help, and current treatments are far from adequate.

What do you hope to bring to your journal?

I hope to continue to raise the profile of ACS Chemical Neuroscience as a premier journal for neuropharmacology research and central nervous system drug discovery.

What are the major challenges facing your field today?

The identification of robust biomarkers that predict treatment efficacy is an issue that continues to plague the development of central nervous system therapeutics. Fortunately, progress in this area is being made.

What do you think is the most interesting and/or important unsolved problem in your field?

Most people now agree that many brain illnesses are a result of pathological neural circuits rather than chemical imbalances. A key challenge for the field going forward will be to find ways to selectively target disease-relevant circuits with brain penetrant small molecules. That type of precision will likely be necessary to both improve efficacy and reduce side effects.

Do you have a recent paper in an ACS journal that you’d like to highlight?

The Subjective Effects of Psychedelics May Not Be Necessary for Their Enduring Therapeutic Effects
ACS Pharmacol. Transl. Sci. 2021, 4, 2, 563–567
DOI: 10.1021/acsptsci.0c00192

Anything else you’d like readers to know about you?

In addition to developing new neurotherapeutics, I’m also very passionate about understanding how psychedelics produce their effects on brain structure and function. Psychedelics are some of the most powerful substances known to impact the brain, and I believe that understanding the basic science underlying their effects will lead to important advances in neuroscience.

Karmella Haynes, ACS Synthetic Biology

What is your research focus? What initially attracted you to your field?

My focus is the rational design of components of chromatin (proteins and scaffold RNAs that organize DNA in chromosomes) to control epigenetic gene regulation in human and mammalian cells. I studied basic epigenetic research as a Ph.D. student. After I entered synthetic biology as a postdoc (ca. 2006), I became excited about the idea of epigenetic engineering in eukaryotes, and mammalian synthetic biology in general.

What do you hope to bring to your journal?

I hope to apply my knowledge of advances and barriers in the area of mammalian synthetic biology to the process of sharing the latest findings with the public. I also hope that my connections with the growing mammalian synthetic biology community will encourage early career and historically marginalized scientists to consider ACS Synthetic Biology as a platform for elevating the visibility of their work.

What are the major challenges facing your field today?

Translating biological design principles from viral and bacterial systems to mammalian cells is a major overarching challenge for mammalian synthetic biology. Mammalian cells have the remarkable ability to differentiate into a myriad of specialized states while remaining genetically identical. This poses a significant challenge for an orthogonal genetic circuit that is intended to function in a predictable manner.

What do you think is the most interesting and/or important unsolved problem in your field?

Solving the problem of unexpected epigenetic regulation of synthetic gene circuits will certainly help to advance mammalian synthetic biology. Also, a widely adopted, easy-to-use artificial chromosome that is stable in replicating mammalian cells would make cells much easier to engineer.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Design, Construction, and Validation of Histone-Binding Effectors in Vitro and in Cells
Biochemistry 2018, 57, 31, 4707–4716
DOI: 10.1021/acs.biochem.8b00327

Daniel Nomura, Chemical Research in Toxicology

What is your research focus? What initially attracted you to your field?

My group is focused on reimagining druggability using chemoproteomic platforms to develop transformative medicines. One of the greatest challenges that we face in discovering new disease therapies is that most proteins are considered “undruggable,” in that most proteins do not possess known binding pockets or “ligandable hotspots” that small molecules can bind to modulate protein function. Our research group addresses this challenge by advancing and applying chemoproteomic platforms to discover and pharmacologically target unique and novel ligandable hotspots for disease therapy.

What do you hope to bring to your journal?

One of the greatest challenges that we face in discovering new disease therapies is that most proteins are considered “undruggable,” in that most proteins do not possess known binding pockets or “ligandable hotspots” that small molecules can bind to modulate protein function. This challenge requires the development of approaches that not only enable ligand discovery against these undruggable targets but also the invention of new therapeutic modalities to therapeutically exploit these targets in a safe manner.
I hope to bring my expertise in chemical biology, drug discovery, and environmental toxicology, particularly as it relates to small-molecule interactions with macromolecules in our bodies.

Doris Braun, Crystal Growth & Design

What is your research focus? What initially attracted you to your field?

The “Preformulation and Polymorphism group” at the University of Innsbruck in Austria focuses on scientific and applied problems related to solid-state properties of pharmaceuticals and other small organic molecules of high industrial relevance. We develop methods, strategies, and guidelines for the production and characterization of solid-state forms and drug products.

In particular, my research focuses on:

  1. The role of computational chemistry for pharmaceutical solid form screening and characterization: how to implement crystal structure prediction into solid form screening and characterization programs.
  2. Thermodynamic relations in solid forms: how to derive the thermodynamic stability, stability order, and stability ranges of and between different solid-state forms
  3. Hydrate, solvate, and co-crystal formation: prediction, characterization, and practical consequences.

The beauty of crystals under the microscope attracted me to the field of polymorphism.

What do you hope to bring to your journal?

Materials properties and their applicability have always been the driving force in my research. I have university training in pharmacy, worked on projects focusing on basic research and applied industrial problems. As a scientist, I have taken the role of an experimentalist among world-leading theoretical chemists, and am now applying computational chemistry in an otherwise experimentally focused research group. I hope to play an integral part in maintaining the high standards of the journal, help to encourage (younger) researchers to publish high-quality papers, and promote out-of-the-box thinking of scientists working in the field.

What are the major challenges facing your field today?

Over the last decade, there have been ground-breaking achievements in the field of crystal engineering/materials sciences. Computational chemistry can be used to predict feasible crystal structures. We are aiming at predicting the properties of materials. Experimental techniques have advanced immensely. High-resolution and in-situ data collections allow us to get insights into the structural behavior, transformations, and interrelations of solid forms. Thus, the challenges we have to overcome in our field are not always related to science but are often linked to the accessibility of the (newest) techniques, the time we can spend working on a compound, and the funding opportunities available.

What do you think is the most interesting and/or important unsolved problem in your field?

Despite the ground-breaking advances in the field and the efforts undertaken by scientists in academia and industry worldwide we are still not able to predict if a molecule will crystallize, let alone in what forms or especially under which conditions. The required breakthrough is probably understanding nucleation and growth in practically relevant systems. The ultimate goal is then to design and produce the assembly of new materials with targeted properties.

Do you have a recent paper in an ACS journal that you’d like to highlight?

The Eight Hydrates of Strychnine Sulfate
Cryst. Growth Des. 2020, 20, 9, 6069–6083
DOI: 10.1021/acs.cgd.0c00777

In this study, we aimed at a comprehensive molecular-level understanding of a hydrate forming model compound. The fact that strychnine sulfate shows eight hydrate forms, but no stable and ordered anhydrous phase, highlights the importance of water as a stabilizing agent in solids. Furthermore, the study demonstrates that a series of complementary analytical techniques allowing precise adjustments of humidity and temperature conditions must be employed to reveal the solid-state behavior of complex hydrate systems.

Sanjit Konar, Crystal Growth & Design

What is your research focus? What initially attracted you to your field?

The focus of my research team is multidirectional, with special emphasis on the thrust areas, namely responsive molecular crystals (mainly MOFs), molecular magnetism, and nanoscopic polyoxometalates. We aim to design and synthesize magnificent molecular materials whose physicochemical properties could be orchestrated using external stimuli such as light, temperature, pressure, etc, and can be used as molecular switches. In these studies, appropriate selection of the ligand field, along with a proper choice of the redox potential of the molecular components plays a vital role. Moreover, other parameters like the arrangement of the molecules in the crystal lattice, mainly driven by intermolecular interactions, often fine-tune the dynamic and reversibility of the properties. The other aspect of our work includes molecular magnetism. We design single-molecule/ion magnets, magnetic refrigerants, and cages and rationalize their properties experimentally and theoretically to make this field significant progress. In another area, we explore the fascinating electronic, catalytic, and magnetic properties of nanoscopic polyoxometalates(POMs) formed by the early transition metals. The intrinsic color of the transition metal complexes attracts me the most as it provides a clear hint about their structure and reactivity.

What do you hope to bring to your journal?

My background is in transitional metal coordination chemistry, and my current research interest in molecular magnetism, metal-organic frameworks, and polyoxometalates may bring complementary expertise to the editorial board of this journal. I hope to contribute to the area of structure-property relationship in the transition metal-based crystalline compounds.

What are the major challenges facing your field today?

The complexities associated with the structure of a small molecule in the crystal lattice considering the intermolecular interactions and its relationship with the properties might need to reach the next level of understanding for a more efficient design of the materials. Although significant efforts have been devoted in this direction, a faster progression could be achieved by the synergy between the design strategy of the molecules and an adequate understanding of the intermolecular interactions involved therein.

What do you think is the most interesting and/or important unsolved problem in your field?

Even for the simplest molecule, predicting the crystal structure may turn out to be wrong.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Magnetic Transition in Organic Radicals: The Crystal Engineering Aspects
Cryst. Growth Des. 2021, 21, 10, 5473–5489
DOI: 10.1021/acs.cgd.1c00731

Anything else you’d like readers to know about you?

Two things need to be mentioned that help me evolve as a researcher: extensive undergraduate teaching and a scientist at home, my wife, also a chemistry professor.

Michael Ruggiero, Crystal Growth & Design

What is your research focus? What initially attracted you to your field?

We are broadly interested in understanding how intermolecular forces shape the properties of condensed phase materials, which we typically achieve through the lens of low-frequency (terahertz) vibrational spectroscopies, supplemented by quantum mechanical simulations. The terahertz vibrational community is one of the most welcoming and collaborative communities I’ve come across, which is the primary reason why I have been in this community from my doctoral studies through my current independent career – basically, great friends, great science, and a whole bunch of fun is what kept me around!

What do you hope to bring to your journal?

I have been impressed with the direction that Crystal Growth & Design has been moving in over the last several years, and I have been quite fortunate to have some of my more ambitious and interesting studies land in the journal. The organic growth of the CGD community, and their keen eye to expanding beyond the traditional crystallography community into related fields, are major driving forces for my desire to be involved. I am very much looking forward to helping to grow the community by acting as a bridge between CGD and the terahertz sciences.

What are the major challenges facing your field today?

The terahertz sciences are rapidly evolving, as instrument costs are decreasing and the technique is easier-than-ever to access. However, with that evolution, there is an influx of new researchers that need to become acquainted with the nuances associated with low-frequency vibrational spectroscopy, which is sufficiently different to comparable methods (e.g., mid-IR vibrational spectroscopies). Thus, there is a need now, more than ever, for detailed studies that clearly highlight experimental methodologies and subsequent analysis techniques.

What do you think is the most interesting and/or important unsolved problem in your field?

One of the most interesting areas of the terahertz sciences, in my opinion, is the increasing finding that solid-state phenomena (reactions, phase transformations, and so on) seem to closely follow a terahertz vibrational normal mode. This has resulted in some interesting and ongoing investigations into driving solid-state reactivity with terahertz radiation, which is one of the ‘holy-grails’ of low-frequency vibrational spectroscopy, in my opinion!

Do you have a recent paper in an ACS journal that you’d like to highlight?

Advances in Low-Frequency Vibrational Spectroscopy and Applications in Crystal Engineering
Cryst. Growth Des. 2022, 22, 2, 939–953
DOI: 10.1021/acs.cgd.1c00850

Anything else you’d like readers to know about you?

I am an avid outdoorsman, and when not playing with lasers you can find me lurking around the Green Mountains of Vermont or the Adirondack Mountains of New York – hiking, camping, skiing, and everything in between – often with my wife and two dogs. I’m also a sucker for a good collaboration, and have a difficult time saying “no” to a fun and interesting problem from a fun and interesting person: basically, we’ll stick anything in our spectrometer, and happily head to the pub for beers after!

Shalini Singh, Crystal Growth & Design

What is your research focus? What initially attracted you to your field?

I am a nanomaterial chemist. Currently, my research focus is on synthesizing ultra-thin inorganic nanocrystals composed of a few atomic layers by bottom-up approaches. Creating them atom-by-atom using molecular precursors provides vast opportunities to engineer their structure, dimensions, surface, and properties. By using different spectroscopic and microscopic techniques, we gain a proper understanding of the stoichiometry, crystal structure, morphology, electronic properties, and surface chemistry of synthesized nanomaterials. Further, depending on their electronic properties, we study their potential as electrode materials for batteries or electrocatalysts. Initially, my research career started from designing polymeric nanocomposites(as a research fellow in India). While I was searching for a Ph.D. position, I saw an advertisement for a position at University of Limerick. The description said that the candidate would be trained on transmission electron microscopes. For me, that was very fascinating. I wanted to take images of nanocrystals with atomic resolution. High-quality TEM images of nanocrystals still make my day. After my Ph.D., I moved to Belgium as a postdoc to study the relationship between the nanocrystal surface and their opto-electronic properties. With different expertise I gained during my research journey helped me to establish my research group at University of Limerick, Ireland on designing and tuning the structure and property of novel nanomaterials for technological applications.

What do you hope to bring to your journal?

As a Topic Editor of Crystal Growth & Design, I will handle manuscripts in the metallic and semiconductor nanocrystals areas. Specifically, I would be handling manuscripts on insights into crystallization and structure-function relationship in nanocrystals synthesized via a bottom-up approach. I am very much looking forward to reading new studies in this area that will contribute to fundamental advances.

What are the major challenges facing your field today?

New semiconductor and metallic nanocrystals with designer and tunable properties are emerging rapidly. However, there is a lack of fundamental understanding of underlying concepts on surface, structure, and crystallization in these different sets of new materials. These missing links often hamper the development of reproducible and scalable ways for the synthesizing, processing, and integration of these new materials in applications. Addressing these fundamental challenges will be important to create a platform technology for an easier lab-to-fab transition of novel nanomaterials.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Yes, I would love to highlight these two recent papers in ACS journals:

Ligand Adsorption Energy and the Postpurification Surface Chemistry of Colloidal Metal Chalcogenide Nanocrystals
Chem. Mater. 2021, 33, 8, 2796–2803
DOI: 10.1021/acs.chemmater.0c04761

In this article, we demonstrated how the actual surface chemistry of ligand passivated colloidal nanocrystals is a combined result of intrinsic ligand-nanocrystals binding character and concrete work-up procedures.

Insights into Nucleation and Growth of Colloidal Quaternary Nanocrystals by Multimodal X-ray Analysis
ACS Nano 2021, 15, 4, 6439–6447
DOI: 10.1021/acsnano.0c08617

In this article, we present a real-time investigation of the formation of colloidal copper zinc tin sulfide nanorods by in situ X-ray absorption spectroscopy and small-angle X-ray scattering. Using this x-ray combination, we unraveled the key nucleation and growth stages in quaternary nanocrystal synthesis.

Anything else you’d like readers to know about you?

Besides research, I am a passionate teacher. I love teaching and creating a new innovative ways to teach organic chemistry to my students. I am also trained in different Indian folk dancing styles. If I were not a chemist, she would own and run my own dance studio.

John Munafo, Journal of Agricultural and Food Chemistry

What is your research focus? What initially attracted you to your field?

Our lab aims to unlock the potential of food, fungi, and plant-based natural products to benefit agriculture and animal and human health. Through flavor chemistry, we aim to identify key aroma and taste active molecules in foods and beverages with the vision of developing “Healthy Foods with Great Flavor.” Through natural products chemistry, we aim to identify biologically active molecules with the vision of developing “Novel Natural Products for Health and Agriculture.” The overarching objectives of our integrated program are to guide the development of healthy foods with great flavor, to develop new specialty crops for farmers, and identify novel preventative and treatment options to combat global health afflictions such as diabetes, cancer, and emerging infectious diseases. What initially attracted me to these intriguing fields of research was the realization that nature contains a virtually limitless supply of bioactive molecules that are waiting to be discovered. Many of these molecules have the potential to benefit humans, animals, and the environment.

What do you hope to bring to your journal?

Flavor science and natural products chemistry are two of my passions. I am particularly interested in studies that contribute to the fundamental aspects of these two disciplines, especially those with the potential to be further developed, in an applied fashion, to benefit people, food, and agriculture.

What are the major challenges facing your field today?

Supplying the world with sustainable, affordable, safe, healthy, and delicious food.

What do you think is the most interesting and/or important unsolved problem in your field?

I find it fascinating that, through trial-and-era, nature has generated an enormous suite of time-tested bioactive molecules with the potential to benefit humans, animals, and the environment. This creates a huge opportunity to discover uses for these natural products to benefit society.

Do you have a recent paper in an ACS journal that you’d like to highlight?

This recently published manuscript details the aroma chemistry of a pleasantly unique smelling mushroom endemic to the Southern Appalachians.

Key Odorants from the Fragrant Bolete, Suillus punctipes
J. Agric. Food Chem. 2020, 68, 32, 8621–8628
DOI: 10.1021/acs.jafc.0c03389

Anything else you’d like readers to know about you?

I enjoy spending time with family and friends, exploring nature, reading, and gardening.

Geoffrey Coates, Journal of the American Chemical Society

What is your research focus? What initially attracted you to your field?

The research focus of the Coates Group is the development of new catalysts for the synthesis of macromolecules and small molecules. Professor Coates’ research concentrates on developing new methods for reacting commodity feedstocks in unprecedented ways. His current research centers on the development of homogeneous catalysts for olefin polymerization, heterocycle carbonylation, epoxide homo- and copolymerization, the utilization of carbon dioxide in polymer synthesis, and new polymers for energy conversion and storage.

What do you hope to bring to your journal?

I hope to bring additional expertise in catalysis and polymer chemistry to the journal.

What do you think is the most interesting and/or important unsolved problem in your field?

Society depends on polymeric materials now more than at any other time in history, despite increasing concern that their synthesis and disposal are unsustainable. The development of new routes to polymers that have reduced environmental impact is one of the most important unsolved problems in the field of polymer chemistry.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Isotactic Poly(propylene oxide): A Photodegradable Polymer with Strain Hardening Properties
J. Am. Chem. Soc. 2020, 142, 14, 6800–6806
DOI: 10.1021/jacs.0c01768

Christophe Coperet, Journal of the American Chemical Society

What is your research focus? What initially attracted you to your field?

I study surface chemistry along with catalysis, nuclear magnetic resonance, X-Ray Absorption, metathesis, and CO2 hydrogenation. I study surface chemistry because of its unusual structure and reactivity. It requires me to try to bridge the gap between molecular and solid-state chemistry.

What do you hope to bring to your journal?

A molecular view on heterogeneous catalysis and the ability to look at interfaces with the eye of a molecular chemist.

What are the major challenges facing your field today?

The requirement for a broad range of expertise (from synthetic molecular chemistry to solid-state chemistry, including the use of advanced multiple spectroscopy techniques, as well as computational approaches) to embrace the complexity of surface chemistry. Also, data analysis is becoming complex and demanding due to the ever-increasing size of the data set, along with time- (Operando) and space-resolved spectroscopy.

What do you think is the most interesting and/or important unsolved problem in your field?

Finding a way to capture the dynamics of surface (active) sites under operating conditions, combining imaging and spectroscopy.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Nanoparticle O–H Bond Dissociation Free Energies from Equilibrium Measurements of Cerium Oxide Colloids
J. Am. Chem. Soc. 2021, 143, 7, 2896–2907
DOI: 10.1021/jacs.0c12799

Anything else you’d like readers to know about you?

I am a fan of literature, philosophy, music, and wine.

Carlos Nieto de Castro, Journal of Chemical and Engineering Data

What is your research focus? What initially attracted you to your field?

My scientific activity covers the field of molecular thermophysics and fluid technology, ionic liquids, nanofluids, ionanofluids, and nanosystems, including new heat and storage fluids with industrial impact in the area of energy and the environment, and the use of ionic liquids as solvating and reaction media to synthesize and functionalize nanomaterials, for industrial and domestic applications. Attracted by thermodynamics and transport processes in chemical systems, namely in a liquid state. To solve new problems in chemical engineering and physical chemistry.

What do you hope to bring to your journal?

My experience in science and technology, from doing, directing, and writing. Rigor in data acquisition and presentation for thermophysical properties of fluids (experiment and modeling). Ethics in publications. My strong belief in the capacity of science and technology, namely chemistry and chemical engineering, to transform the world.

What are the major challenges facing your field today?

Nanomaterials characterization, new heat transfer, and storage fluids and materials, use of renewable energies, namely solar, in domestic and industrial applications. The lack of financing in physical chemistry/thermophysical research. The resistance of young people to think scientifically.

What do you think is the most interesting and/or important unsolved problem in your field?

Liquid state molecular theory. Structure of nanofluids and parent dispersions.

Do you have a recent paper in an ACS journal that you’d like to highlight?

It is not very recent but it was a fundamental paper for the use of ionic liquids as base fluids for nanofluids. The term IoNanofluids was created then and sprayed over in the literature:
Thermal Properties of Ionic Liquids and IoNanofluids of Imidazolium and Pyrrolidinium Liquids
J. Chem. Eng. Data 2010, 55, 2, 653–661
DOI: 10.1021/je900648p

Another one fundamental in the area:

Influence of Thermophysical Properties of Ionic Liquids in Chemical Process Design
J. Chem. Eng. Data 2009, 54, 9, 2569–2575
DOI: 10.1021/je900107t

The most recent one:

Thermophysical Properties of 1-Butyl-3-methylimidazolium tris(pentafluoroethyl)trifluorophosphate, [C4mim][(C2F5)3PF3], and of Its IoNanofluid with Multi-Walled Carbon Nanotubes
J. Chem. Eng. Data 2021, 66, 4, 1717–1729
DOI: 10.1021/acs.jced.0c01017

Anything else you’d like readers to know about you?

I am one of the world’s most cited top scientists in chemical engineering/physical chemistry, in the top 2% for 2020 and 2021, according to Stanford University.

Nanshu Lu, Nano Letters

What is your research focus? What initially attracted you to your field?

My research focuses on thin-film mechanics and soft bio-integrated electronics. Representative works of my group include stretchability of metal thin films and serpentine ribbons, nano-bubbles and nano-tents formed by 2D materials, epidermal electronics, graphene e-tattoos (GETs), “cut-solder-paste” rapid prototyping of wireless e-tattoos, bio-electronics interface mechanics, and hybrid piezoresistive and piezocapacitive responses of pressure sensing e-skins. I enjoy both achieving the fundamental understanding of the mechanics of thin-film materials as well as making technical advancements enabled by those fundamental understandings.

What do you hope to bring to your journal?

I hope that my expertise in thin-film mechanics and soft devices can be an unconventional addition to Nano Letters because it is no longer just limited to chemistry or chemical engineering. Instead, we are trying to recognize that mechanics, materials, and electronics all contribute synergistically to future devices with hybrid nano and macro components.

What are the major challenges facing your field today?

A major scientific challenge is the synthesis of intrinsically soft and stretchable high-performance electronic materials such as organic conductors and semiconductors, which can ultimately replace metal and silicon while still being tissue soft. A major technical challenge is the reliable and robust interfacing of the soft, nano components with rigid, macroscopic components like silicon chips or printed circuit boards.

What do you think is the most interesting and/or important unsolved problem in your field?

I envision that in the future, humans will be more like robots (i.e., digital, computational, connected to the internet, etc.) whereas robots will be more like humans (i.e., soft, human-mimetic actuation and sensation, artificial intelligence, etc.). To achieve this vision, we need better brain probes to decipher the human brain and better soft actuators to behave like artificial muscles.

Do you have a recent paper in an ACS journal that you’d like to highlight?

I was one of the iCANx/ACS Nano inaugural rising star lecturers in 2020. Therefore, I just submitted an invited perspective on soft capacitive pressure sensors to ACS Nano. I hope to share it when this perspective is published.

Anything else you’d like readers to know about you?

I endeavor to break the barriers between disciplines and I need everyone’s help with that.

Liberato Manna, Nano Letters

What is your research focus? What initially attracted you to your field?

My main research focus is on colloidal nanocrystals. My group targets their synthesis, surface functionalization, modeling, the study of their physical properties, and their applications, mainly in energy-related fields.

What do you hope to bring to your journal?

I hope to bring my expertise in nanoscale materials science, both from a chemistry and physics perspective, and to cover a wide array of materials and properties.

What are the major challenges facing your field today?

There are several challenges. I would mention perhaps only two. One is getting nanoscale materials that are stable and that have a level of environmental compatibility that makes them suitable for widespread applicability. A second important issue is related to the reproducibility of results from lab to lab, which will require more standardized procedures, sharing of raw data, and certification of performances on a broader scale than has been done so far.

What do you think is the most interesting and/or important unsolved problem in your field?

I am now working mainly in the field of halide perovskites. The most unsolved issue in this field is to find valid alternatives to lead-based compositions. This is still an open quest. Another important challenge in colloidal chemistry, in general, is being able to synthesize materials, in the form of high-quality colloidal nanocrystals, that in the bulk require high temperatures to be prepared with good crystallinity and/or in a desired phase/composition.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Sb-Doped Metal Halide Nanocrystals: A 0D versus 3D Comparison
ACS Energy Lett. 2021, 6, 6, 2283–2292
DOI: 10.1021/acsenergylett.1c00789

This recent work from our group stresses the importance of the extent of connectivity of the coordination polyhedra on one side, and or surface trap states on the other side, on regulating the optical properties of nanoscale metal halide crystals.

Anything else you’d like readers to know about you?

Please don’t focus only on science, but cultivate other interests that enrich your life and make you a more complete person.

Elena Besley, Nano Letters

What is your research focus? What initially attracted you to your field?

I am working in the field of theoretical and computational chemistry. I very much like the rigor of theoretical methods, which we use to interpret and predict the outcomes of experimental observations. Mathematics allows us to treat a physical problem with a high level of accuracy and precision, yet often leads us to general conclusions about the underlying mechanisms.

What do you hope to bring to your journal?

Computational science is still at the very beginning of its growth as compared to experimental science, which already enjoyed four centuries of development and advancement. With Nano Letters, I hope to create a strong platform for computational science that can be used to explore nanoscale phenomena not always directly accessible to experiment in key scientific areas such as atmospheric science, materials science, molecular biology, colloidal chemistry, aerodynamics, and elementary particle physics, to name a few. I hope to highlight the highest quality development works by computational chemists, mathematical chemists, and physicists, chemical informaticians who underpin and explain new ground-breaking experimental results.

What are the major challenges facing your field today?

The major challenge that faces us is to develop our abilities to pose and solve problems that combine insights from more than one discipline within the natural sciences with mathematical tools and computational skills. This provides a unique combination of applied and theoretical knowledge.

What do you think is the most interesting and/or important unsolved problem in your field?

We need to continue developing new computational methods that make challenging physical and chemical problems more tractable on modern computing platforms. We also need to change the future of computer simulations. For example, combining machine learning and data analysis with quantum computing is an exciting topic, which can completely change the future of computer simulations and the way we study physical systems at the nanoscale. There are also many unresolved problems in algorithm development, error control, and software productivity.

Do you have a recent paper in an ACS journal that you’d like to highlight?

Triplet Excitation and Electroluminescence from a Supramolecular Monolayer Embedded in a Boron Nitride Tunnel Barrier
Nano Lett. 2020, 20, 1, 278–283
DOI: 10.1021/acs.nanolett.9b03787

In this paper, we show that ordered monolayers of organic molecules stabilized by hydrogen bonding on the surface of exfoliated few-layer hexagonal boron nitride (hBN) flakes may be incorporated into van der Waals heterostructures with integral few-layer graphene contacts forming a molecular/two-dimensional hybrid tunneling diode. Electrons can tunnel through the hBN/molecular barrier under an applied voltage, and we show that tunneling electrons excite embedded molecules into singlet states in a two-step process via an intermediate triplet state through inelastic scattering and also observe direct emission from the triplet state. These heterostructures provide a solid-state device in which spin-triplet states, which cannot be generated by optical transitions, can be controllably excited and provide a new route to investigate the physics, chemistry, and quantum spin-based applications of triplet generation, emission, and molecular photon upconversion.

More Opportunities to Showcase Your Research on an ACS Journal Cover!

ACS Publications is pleased to enhance our supplementary cover art programan opportunity for you to promote your published research and present your findings in a way that is novel and visually impactful. Effective at the end of January 2022, we have expanded the maximum number of supplementary covers available from three per journal issue to four per journal issue. Additionally, future supplementary covers will now be featured as a thumbnail on the related published article webpage, in addition to the PDF:

By having your research featured on a supplementary journal cover, you have the opportunity to increase the visibility of your published article. ACS still provides supplementary cover authors with an 18” x 24” printed poster personalized with the article title and first author’s name, along with a high-resolution graphic file for inclusion in scientific talks and presentations, for use on lab websites, or to post on social media. Your supplementary cover will be featured on your published article and the journal website, and we will reshare it on ACS Publications’ social media platforms.

If you are invited to submit a revision to any ACS journal, you can submit your cover art for consideration as one of the journal’s supplementary covers. The program is now available for authors who publish in all ACS journals.

Hear more from some of the authors who have participated in the program:

I framed the JACS cover art image and posted it in the hallway, so everyone can see this. This is an excellent way to promote our science, not only to the chemistry community but also to the general public.

-Seung Bum Park, Seoul National University

We have developed a cosmetic product range called Dr. Craft, and one of our products contains blackcurrant anthocyanins. When launching the new products in 2018 we wanted to cover as many promotional opportunities as possible and this cover art was a fantastic part of that. We also used the poster when we participated in the ACS GC&E Product Showcase.

-Richard Blackburn, University of Leeds

The cover picture is quite helpful to advertise to 3rd-year undergraduate students, who are choosing a research group to join. Although they don’t necessarily understand our research, they can see the activity of our research as well as the atmosphere of our group. As a result, highly motivated students joined our laboratory, it’s great!

-Itaru Nakamura, Tohoku University

Learn more about the expanded supplementary cover art program and how you can showcase your research further for the world to see!

Select ACS Publications Journals Join ScienceDirect Access Pilot

Today, ACS Publications is embarking on an experimental pilot initiative to help you find and access content more efficiently. We are partnering with Elsevier, Royal Society of Chemistry (RSC), Taylor & Francis, and Wiley for a pilot in which select journals will be accessible through Elsevier’s online platform – ScienceDirect.

Leveraging Get Full Text Research (GetFTR), the pilot brings together unique and high-impact organic chemistry content – more than 70,000 articles in 35 journals – that furthers cross-publisher discoverability. We hope that as a result of this collaboration, you will benefit from increased visibility of your work, thereby maximizing the full potential of each research outcome.

The participating ACS journals involved in this pilot project are:

  • Biomacromolecules
  • Organic Letters
  • The Journal of Organic Chemistry
  • Bioconjugate Chemistry
  • Organometallics
  • Organic Process Research & Development

Approximately 34,000 ACS articles from the aforementioned journals will be visible on ScienceDirect, as well as of course on the ACS Publications platform. Throughout the pilot, we will monitor the impact of this effort to determine whether it helps make the content more discoverable to global research communities.

We invite you to visit Elsevier’s Connect blog to learn more about this exciting pilot, as well as this Scholarly Kitchen article for more details.