ACS Congratulates the 2015 Nobel Laureates in Chemistry

Congratulations to Tomas Lindahl of the Francis Crick Institute and Clare Hall Laboratory in England, Paul Modrich of Duke University School of Medicine, and Aziz Sancar of the University of North Carolina School of Medicine, who were awarded the 2015 Nobel Prize in Chemistry for their mechanistic studies of three different types of DNA repair. Tomas Lindahl was honored for his discoveries on base excision repair — the cellular mechanism that repairs damaged DNA during the cell cycle. Paul Modrich was recognized for showing how cells correct errors that occur when DNA is replicated during cell division. Aziz Sancar was awarded for mapping the mechanism cells use to repair ultraviolet damage to DNA.

Read more about their research in Chemical & Engineering News.

View their research from Biochemistry and Chemical Reviews, which are freely available only for a limited time.

 

Rate of depurination of native deoxyribonucleic acid
Lindahl, T. and B. Nyberg
Biochemistry, 1972, 11(19): p. 3610-8

Rate of chain breakage at apurinic sites in double-stranded deoxyribonucleic acid
Lindahl, T. and A. Andersson
Biochemistry, 1972, 11(19): p. 3618-23

Heat-induced deamination of cytosine residues in deoxyribonucleic acid
Lindahl, T. and B. Nyberg
Biochemistry, 1974, 13(16): p. 3405-10

Photochemical properties of Escherichia coli DNA photolyase: a flash photolysis study
Paul F. Heelis, Aziz Sancar
Biochemistry, 1986, 25 (25), pp 8163–8166
Publication Date: December 1, 1986 (Article)
DOI: 10.1021/bi00373a006

Photochemical properties of Escherichia coli DNA photolyase: selective photodecomposition of the second chromophore
Paul F. Heelis, Gillian Payne, Aziz Sancar
Biochemistry, 1987, 26 (15), pp 4634–4640
Publication Date: July 1, 1987 (Article)
DOI: 10.1021/bi00389a007

The active form of Escherichia coli DNA photolyase contains a fully reduced flavin and not a flavin radical, both in vivo and in vitro
Gillian Payne, Paul F. Heelis, Brian R. Rohrs, Aziz Sancar
Biochemistry, 1987, 26 (22), pp 7121–7127
Publication Date: November 1, 1987 (Article)
DOI: 10.1021/bi00396a038

Binding of Escherichia coli DNA photolyase to UV-irradiated DNA
Gwendolyn B. Sancar, Frances W. Smith, Aziz Sancar
Biochemistry, 1985, 24 (8), pp 1849–1855
Publication Date: April 1, 1985 (Article)
DOI: 10.1021/bi00329a007

DNA Mismatch Repair:  Functions and Mechanisms
Ravi R. Iyer, Anna Pluciennik, Vickers Burdett, and Paul L. Modrich
Chem. Rev., 2006, 106 (2), pp 302–323
Publication Date (Web): December 23, 2005 (Article)
DOI: 10.1021/cr0404794