Pacifichem 2015: Organic Chemistry

Organic chemistry plays a central role in drug development, biotechnology, materials science, and wide range of other fields. In our daily lives, applications of organic chemistry are ubiquitous. The collection of articles featured here illustrates the broad scope and high quality of organic chemistry published in the journals of the American Chemical Society. Many of the authors of these articles will be presenting their research results at Pacifichem 2015, highlighting developments in bond activation, organocatalysis, green chemistry, supramolecular chemistry, natural products, process development, and more.

 

ACS Catalysis

Mechanistic Studies of Gold and Palladium Cooperative Dual-Catalytic Cross-Coupling Systems

Mohammad Al-Amin, Katrina E. Roth, and Suzanne A. Blum

ACS Catalysis 2014 4 (2), 622-629

DOI: 10.1021/cs400641k

 

Synthesis of Carbazoles by a Merged Visible Light Photoredox and Palladium-Catalyzed Process

Sungkyu Choi, Tanmay Chatterjee, Won Joon Choi, Youngmin You, and Eun Jin Cho

ACS Catalysis 2015 5 (8), 4796-4802

DOI: 10.1021/acscatal.5b00817

 

Recent Applications of Organic Dyes as Photoredox Catalysts in Organic Synthesis

David A. Nicewicz and Tien M. Nguyen

ACS Catalysis 2014 4 (1), 355-360

DOI: 10.1021/cs400956a

 

 

ACS Chemical Biology

Anatomy of beta-Strands at Protein-Protein Interfaces

Andrew M. Watkins and Paramjit S. Arora

ACS Chemical Biology 2014 9 (8), 1747-1754

DOI: 10.1021/cb500241y

 

Synthetic Antibodies with a Human Framework That Protect Mice from Lethal Sudan Ebolavirus Challenge

Gang Chen, Jayne F. Koellhoffer, Samantha E. Zak, Julia C. Frei, Nina Liu, Hua Long, Wei Ye, Kaajal Nagar, Guohua Pan, Kartik Chandran, John M. Dye, Sachdev S. Sidhu, and Jonathan R. Lai

ACS Chemical Biology 2014 9 (10), 2263-2273

DOI: 10.1021/cb5006454

 

Protein Kinase C delta Is a Therapeutic Target in Malignant Melanoma with NRAS Mutation

Asami Takashima, Brandon English, Zhihong Chen, Juxiang Cao, Rutao Cui, Robert M. Williams, and Douglas V. Faller

ACS Chemical Biology 2014 9 (4), 1003-1014

DOI: 10.1021/cb400837t

 

 

Crystal Growth & Design

Polymorphism in a Sulfamethoxazole Derivative: Coexistence of Five Polymorphs in Methanol at Room Temperature

Muhammad Nawaz Tahir, Zahid Shafiq, Hazoor Ahmad Shad, Zia-ur-Rehman, Abdul Karim, and Muhammad Moazzam Naseer

Crystal Growth & Design 2015 15 (10), 4750-4755

DOI: 10.1021/acs.cgd.5b01126

 

 

Inorganic Chemistry

Carbon- Hydrogen Bond Activation, C- N Bond Coupling, and Cycloaddition Reactivity of a Three- Coordinate Nickel Complex Featuring a Terminal Imido Ligand

Daniel J. Mindiola, Rory Waterman, Vlad M. Iluc, Thomas R. Cundari, and Gregory L. Hillhouse

Inorganic Chemistry 2014 53 (24), 13227-13238

DOI: 10.1021/ic5026153

 

 

Journal of Organic Chemistry

A Perspective on Physical Organic Chemistry

Matthew S. Platz

The Journal of Organic Chemistry 2014 79 (6), 2341-2353

DOI: 10.1021/jo500044d

 

Organotrifluoroborates: Another Branch of the Mighty Oak

Gary A. Molander

The Journal of Organic Chemistry 2015 80 (16), 7837-7848

DOI: 10.1021/acs.joc.5b00981

 

Total Synthesis of Brazilin

Youngeun Jung and Ikyon Kim

The Journal of Organic Chemistry 2015 80 (3), 2001-2005

DOI: 10.1021/jo502745j

 

 

Journal of the American Chemical Society

Intramolecular Insertions into Unactivated C(sp3)–H Bonds by Oxidatively Generated β-Diketone-α-Gold Carbenes: Synthesis of Cyclopentanones

Youliang Wang, Zhitong Zheng, and Liming Zhang

Journal of the American Chemical Society 2015 137 (16), 5316-5319

DOI: 10.1021/jacs.5b02280

 

Palladium-Catalyzed Intramolecular Insertion of Alkenes into the Carbon–Nitrogen Bond of β-Lactams

Akira Yada, Satoshi Okajima, and Masahiro Murakami

Journal of the American Chemical Society 2015 137 (27), 8708-8711

DOI: 10.1021/jacs.5b05308

 

N-Heterocyclic Carbene Nitric Oxide Radicals

Junbeom Park, Hayoung Song, Youngsuk Kim, Bit Eun, Yonghwi Kim, Dae Young Bae, Sungho Park, Young Min Rhee, Won Jong Kim, Kimoon Kim, and Eunsung Lee

Journal of the American Chemical Society 2015 137 (14), 4642-4645

DOI: 10.1021/jacs.5b01976

 

Organic Letters

Cobalt-Catalyzed C-H Cyanation of (Hetero)arenes and 6-Arylpurines with N-Cyanosuccinimide as a New Cyanating Agent

Amit B. Pawar and Sukbok Chang

Organic Letters 2015 17 (3), 660-663

DOI: 10.1021/ol503680d

 

Enantioselective Synthesis of Bicyclic delta-Lactones via N-Heterocyclic Carbene-Catalyzed Cascade Reaction

Zhi-Qin Liang, Dong-Ling Wang, Han-Ming Zhang, and Song Ye

Organic Letters 2015 17 (20), 5140-5143

DOI: 10.1021/acs.orglett.5b02695

 

Elucidation of Pyranonigrin Biosynthetic Pathway Reveals a Mode of Tetramic Acid, Fused γ-Pyrone and exo-Methylene Formation

Tsuyoshi Yamamoto, Yuta Tsunematsu, Hiroshi Noguchi, Kinya Hotta, and Kenji Watanabe

Organic Letters 2015 17 (20), 4992-4995

DOI: 10.1021/acs.orglett.5b02435

 

Organic Process Research & Development

Development of a Continuous Flow Sulfoxide Imidation Protocol Using Azide Sources under Superacidic Conditions

Bernhard Gutmann, Petteri Elsner, Anne O’Kearney-McMullan, William Goundry, Dominique M. Roberge, and C. Oliver Kappe

Organic Process Research & Development 2015 19 (8), 1062-1067

DOI: 10.1021/acs.oprd.5b00217

 

PhenoFluor: Practical Synthesis, New Formulation, and Deoxyfluorination of Heteroaromatics

Teppei Fujimoto, Fabian Becker, and Tobias Ritter

Organic Process Research & Development 2014 18 (8), 1041-1044

DOI: 10.1021/op500121w

 

Rapid Electrochemical Deprotection of the Isonicotinyloxycarbonyl Group from Carbonates and Thiocarbonates in a Microfluidic Reactor

Kenta Arai and Thomas Wirth

Organic Process Research & Development 2014 18 (11), 1377-1381

DOI: 10.1021/op500155f

 

Organometallics

N–H and N–C Bond Formation with an N2-Derived Dihafnium μ-Nitrido Complex

Scott P. Semproni and Paul J. Chirik

Organometallics 2014 33 (14), 3727-3737

DOI: 10.1021/om500393n

Iron Catalysts Containing Amine(imine)diphosphine P-NH-N-P Ligands Catalyze both the Asymmetric Hydrogenation and Asymmetric Transfer Hydrogenation of Ketones

Weiwei Zuo, Sebastian Tauer, Demyan E. Prokopchuk, and Robert H. Morris

Organometallics 2014 33 (20), 5791-5801

DOI: 10.1021/om500479q

Reactivity of an Unsaturated Iridium(III) Phosphoramidate Complex, [Cp*Ir{κ2- N, O} ] [BArF4]

Marcus W. Drover, Heather C. Johnson, Laurel L. Schafer, Jennifer A. Love, and Andrew S. Weller

Organometallics 2015 34 (15), 3849-3856

DOI: 10.1021/acs.organomet.5b00397