Pacifichem 2015: Bench to Bedside

Chemistry plays a central role in the advancement of modern medicine. Although chemistry has long been the foundation for the discovery and development of therapeutics, its contributions to the fight against disease are continually expanding. From research on nutraceuticals and functional foods that provides a foundation of knowledge for the promotion of health and reduction of risk for chronic diseases, to the development of nanoparticles for targeted drug delivery and molecular imaging, chemistry’s reach affects the prevention, diagnosis and treatment of disease.

To supplement the exciting presentations in the “Bench to Bedside: Chemistry of Health Care” technical symposium to be held at PACIFICHEM, ACS Publications has assembled a collection of articles that highlight the diverse contributions of chemistry to health care. The collection includes a number of articles on subjects including small molecule therapeutics, drug conjugates, drug delivery systems, imaging, tissue engineering, and functional foods. We hope you enjoy the collection and continue to support efforts to move chemistry from bench to bedside and beyond.

 

ACS Biomaterials Science & Engineering

Macromolecular and Inorganic Nanomaterials Scaffolds for Carbon Monoxide Delivery: Recent Developments and Future Trends

Diep Nguyen and Cyrille Boyer

ACS Biomaterials Science & Engineering 2015 1 (10), 895-913

DOI: 10.1021/acsbiomaterials.5b00230

 

Initial Cell Adhesion on Well-Defined Surface by Polymer Brush Layers with Varying Chemical Structures

Kazuhiko Ishihara, Tomomi Kitagawa, and Yuuki Inoue

ACS Biomaterials Science & Engineering 2015 1 (2), 103-109

DOI: 10.1021/ab500048w

 

ACS Infectious Diseases

Inhibiting the β-Lactamase of Mycobacterium tuberculosis (Mtb) with Novel Boronic Acid Transition-State Inhibitors (BATSIs)

Sebastian G. Kurz, Saugata Hazra, Christopher R. Bethel, Chiara Romagnoli, Emilia Caselli, Fabio Prati, John S. Blanchard, and Robert A. Bonomo

ACS Infectious Diseases 2015 1 (6), 234-242

DOI: 10.1021/acsinfecdis.5b00003

 

Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus aureus and Its Abrogation by Small Molecules

Marc A. Boudreau, Jennifer Fishovitz, Leticia I. Llarrull, Qiaobin Xiao, and Shahriar Mobashery

ACS Infectious Diseases 2015 1 (10), 454-459

DOI: 10.1021/acsinfecdis.5b00086

 

ACS Macro Letters

Generating Better Medicines for Cancer

Stuart S. Dunn, James D. Byrne, Jillian L. Perry, Kai Chen, and Joseph M. DeSimone

ACS Macro Letters 2013 2 (5), 393-397

DOI: 10.1021/mz400116a

 

 

ACS Medicinal Chemistry Letters

Effectively Delivering a Unique Hsp90 Inhibitor Using Star Polymers

Seong Jong Kim, Deborah M. Ramsey, Cyrille Boyer, Thomas P. Davis, and Shelli R. McAlpine

ACS Medicinal Chemistry Letters 2013 4 (10), 915-920

DOI: 10.1021/ml400082b

 

Discovery and Development of Potent and Selective Inhibitors of Histone Methyltransferase G9a

Ramzi F. Sweis, Marina Pliushchev, Peter J. Brown, Jun Guo, Fengling Li, David Maag, Andrew M. Petros, Nirupama B. Soni, Chris Tse, Masoud Vedadi, Michael R. Michaelides, Gary G. Chiang, and William N. Pappano

ACS Medicinal Chemistry Letters 2014 5 (2), 205-209

DOI: 10.1021/ml400496h

 

Biomacromolecules

Oligonucleotide Immobilization and Hybridization on Aldehyde Functionalized Poly(2-Hydroxyethyl Methacrylate) Brushes

Tugba Bilgic and Harm-Anton Klok

Biomacromolecules 2015 16 (11), 3657-3665

DOI: 10.1021/acs.biomac.5b01116

 

Imine Hydrogels with Tunable Degradability for Tissue Engineering

Natalie Boehnke, Cynthia Cam, Erhan Bat, Tatiana Segura, and Heather D. Maynard

Biomacromolecules 2015 16 (7), 2101-2108

DOI: 10.1021/acs.biomac.5b00519

 

Drug Carriers for the Delivery of Therapeutic Peptides

Alice W. Du and Martina H. Stenzel

Biomacromolecules 2014 15 (4), 1097-1114

DOI: 10.1021/bm500169p

 

Chemical Research in Toxicology

Nanotoxicity of Silver Nanoparticles to Red Blood Cells: Size Dependent Adsorption, Uptake, and Hemolytic Activity

Li Qiang Chen, Li Fang, Jian Ling, Cheng Zhi Ding, Bin Kang, and Cheng Zhi Huang

Chemical Research in Toxicology 2015 28 (3), 501-509

DOI: 10.1021/tx500479m

 

Inorganic Chemistry

Rational Design of a Cytotoxic Dinuclear Cu2 Complex That Binds by Molecular Recognition at Two Neighboring Phosphates of the DNA Backbone

Thomas Jany, Alexander Moreth, Claudia Gruschka, Andy Sischka, Andre Spiering, Mareike Dieding, Ying Wang, Susan Haji Samo, Anja Stammler, Hartmut Bögge, Gabriele Fischer von Mollard, Dario Anselmetti, and Thorsten Glaser

Inorganic Chemistry 2015 54 (6), 2679-2690

DOI: 10.1021/ic5028465

 

Journal of Agricultural & Food Chemistry

Low Molecular Weight Phenolics of Grape Juice and Winemaking Byproducts: Antioxidant Activities and Inhibition of Oxidation of Human Low-Density Lipoprotein Cholesterol and DNA Strand Breakage

Adriano Costa de Camargo, Marisa Aparecida Bismara Regitano-d’Arce, Aline Camarão Telles Biasoto, and Fereidoon Shahidi

Journal of Agricultural and Food Chemistry 2014 62 (50), 12159-12171

DOI: 10.1021/jf504185s

 

Targeting Cancer Stem Cells in Breast Cancer: Potential Anticancer Properties of 6-Shogaol and Pterostilbene

Chi-Hao Wu, Bo-Han Hong, Chi-Tang Ho, and Gow-Chin Yen

Journal of Agricultural and Food Chemistry 2015 63 (9), 2432-2441

DOI: 10.1021/acs.jafc.5b00002

 

Journal of Medicinal Chemistry

Shuttle-Cargo Fusion Molecules of Transport Peptides and the hD(2/3) Receptor Antagonist Fallypride: A Feasible Approach To Preserve Ligand-Receptor Binding?

Carmen Wängler, Shafinaz Chowdhury, Georg Höfner, Petia Djurova, Enrico O. Purisima, Peter Bartenstein, Björn Wängler, Gert Fricker, Klaus T. Wanner, and Ralf Schirrmacher

Journal of Medicinal Chemistry 2014 57 (10), 4368-4381

DOI: 10.1021/jm5004123

 

Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP

Feng Liu, Dalia Barsyte-Lovejoy, Fengling Li, Yan Xiong, Victoria Korboukh, Xi-Ping Huang, Abdellah Allali-Hassani, William P. Janzen, Bryan L. Roth, Stephen V. Frye, Cheryl H. Arrowsmith, Peter J. Brown, Masoud Vedadi, and Jian Jin

Journal of Medicinal Chemistry 2013 56 (21), 8931-8942

DOI: 10.1021/jm401480r

 

Molecular Pharmaceutics

Effective Delivery of siRNA into Cancer Cells and Tumors Using Well-Defined Biodegradable Cationic Star Polymers

Cyrille Boyer, Joann Teo, Phoebe Phillips, Rafael B. Erlich, Sharon Sagnella, George Sharbeen, Tanya Dwarte, Hien T. T. Duong, David Goldstein, Thomas P. Davis, Maria Kavallaris, and Joshua McCarroll

Molecular Pharmaceutics 2013 10 (6), 2435-2444

DOI: 10.1021/mp400049e

 

PET Imaging of Fatty Acid Amide Hydrolase with [F-18]DOPP in Nonhuman Primates

Benjamin H. Rotstein, Hsiao-Ying Wey, Timothy M. Shoup, Alan A. Wilson, Steven H. Liang, Jacob M. Hooker, and Neil Vasdev

Molecular Pharmaceutics 2014 11 (11), 3832-3838

DOI: 10.1021/mp500316h

 

Organometallics

Cytotoxicity and NMR Studies of Platinum Complexes with Cyclooctadiene Ligands

Mirja Enders, Benjamin Görling, Alexander B. Braun, Judith E. Seltenreich, Linus F. Reichenbach, Kari Rissanen, Martin Nieger, Burkhard Luy, Ute Schepers, and Stefan Bräse

Organometallics 2014 33 (15), 4027-4034

DOI: 10.1021/om500540x

 

Organometallic Titanocene–Gold Compounds as Potential Chemotherapeutics in Renal Cancer. Study of their Protein Kinase Inhibitory Properties

Jacob Fernández-Gallardo, Benelita T. Elie, Florian J. Sulzmaier, Mercedes Sanaú, Joe W. Ramos, and María Contel

Organometallics 2014 33 (22), 6669-6681

DOI: 10.1021/om500965k