ACS Editors’ Choice: Developing New Treatments for Hepatitis C, Improving Biorefineries — and More!

Hepatitis C

This week: fighting Hepatitis C with derivatives from an over-the-counter antihistamine, a process that could improve the economic viability of modern biorefineries, a look at fetal exposure to antidepressants in mice – and more!

Each and every day, ACS grants free access to a new peer-reviewed research article from one of the Society’s journals. These articles are specially chosen by a team of scientific editors of ACS journals from around the world to highlight the transformative power of chemistry. Access to these articles will remain open to all as a public service.

Check out this week’s picks!

Maternal Pharmacokinetics and Fetal Disposition of (±)-Citalopram during Mouse Pregnancy

cn-2015-00287p_0009

Juan C. Velasquez, Nick Goeden, Skyla M. Herod, and Alexandre Bonnin

ACS Chem. Neurosci., Article ASAP

DOI: 10.1021/acschemneuro.5b00287

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Isolation and Structural Characterization of a Mackay 55-Metal-Atom Two-Shell Icosahedron of Pseudo-Ih Symmetry, Pd55L123-CO)20 (L = PR3, R = Isopropyl): Comparative Analysis with Interior Two-Shell Icosahedral Geometries in Capped Three-Shell Pd145, Pt-Centered Four-Shell Pd–Pt M165, and Four-Shell Au133 Nanoclusters

ja-2015-130767_0004

Jeremiah D. Erickson, Evgueni G. Mednikov, Sergei A. Ivanov, and Lawrence F. Dahl

Am. Chem. Soc., Article ASAP

DOI: 10.1021/jacs.5b13076

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Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection

Hepatitis C

Shanshan He, Jingbo Xiao, Andrés E. Dulcey, Billy Lin, Adam Rolt, Zongyi Hu, Xin Hu, Amy Q. Wang, Xin Xu, Noel Southall, Marc Ferrer, Wei Zheng, T. Jake Liang, and Juan J. Marugan

Med. Chem., Article ASAP

DOI: 10.1021/acs.jmedchem.5b00752

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Prebiotic NH3 Formation: Insights from Simulations

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András Stirling, Tamás Rozgonyi, Matthias Krack, and Marco Bernasconi

Inorg. Chem., Article ASAP

DOI: 10.1021/acs.inorgchem.5b02911

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A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo

cb-2015-010065_0005

Maruti Uppalapati, Dong Jun Lee, Kalyaneswar Mandal, Hongyan Li§, Les P. Miranda, Joshua Lowitz, John Kenney, Jarrett J. Adams, Dana Ault-Riché#, Stephen B. H. Kent, and Sachdev S. Sidhu

ACS Chem. Biol., Article ASAP

DOI: 10.1021/acschembio.5b01006

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Catalytic H2O2 Disproportionation and Electrocatalytic O2 Reduction by a Functional Mimic of Heme Catalase: Direct Observation of Compound 0 and Compound I in Situ

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Kushal Sengupta, Sudipta Chatterjee, and Abhishek Dey

ACS Catal., 2016, 6, pp 1382–1388

DOI: 10.1021/acscatal.5b02668

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Base-Catalyzed Depolymerization of Biorefinery Lignins

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Rui Katahira, Ashutosh Mittal, Kellene McKinney, Xiaowen Chen, Melvin P. Tucker, David K. Johnson, and Gregg T. Beckham

ACS Sustainable Chem. Eng., Article ASAP

DOI: 10.1021/acssuschemeng.5b01451

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If you have comments or questions for the author of this post, please e-mail: Axial@acs.org.