This week: fighting Hepatitis C with derivatives from an over-the-counter antihistamine, a process that could improve the economic viability of modern biorefineries, a look at fetal exposure to antidepressants in mice – and more! Each and every day, ACS grants free access to a new peer-reviewed research article from one of the Society’s journals. These […]

Hepatitis C

This week: fighting Hepatitis C with derivatives from an over-the-counter antihistamine, a process that could improve the economic viability of modern biorefineries, a look at fetal exposure to antidepressants in mice – and more!

Each and every day, ACS grants free access to a new peer-reviewed research article from one of the Society’s journals. These articles are specially chosen by a team of scientific editors of ACS journals from around the world to highlight the transformative power of chemistry. Access to these articles will remain open to all as a public service.

Check out this week’s picks!

Maternal Pharmacokinetics and Fetal Disposition of (±)-Citalopram during Mouse Pregnancy

cn-2015-00287p_0009
cn-2015-00287p_0009

Juan C. Velasquez, Nick Goeden, Skyla M. Herod, and Alexandre Bonnin

DOI: 10.1021/acschemneuro.5b00287

***

Isolation and Structural Characterization of a Mackay 55-Metal-Atom Two-Shell Icosahedron of Pseudo-Ih Symmetry, Pd55L12(μ3-CO)20 (L = PR3, R = Isopropyl): Comparative Analysis with Interior Two-Shell Icosahedral Geometries in Capped Three-Shell Pd145, Pt-Centered Four-Shell Pd–Pt M165, and Four-Shell Au133 Nanoclusters

ja-2015-130767_0004
ja-2015-130767_0004

Jeremiah D. Erickson, Evgueni G. Mednikov, Sergei A. Ivanov, and Lawrence F. Dahl

DOI: 10.1021/jacs.5b13076

***

Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection

 Hepatitis C
Hepatitis C
ic-2015-029115_0004
ic-2015-029115_0004

András Stirling, Tamás Rozgonyi, Matthias Krack, and Marco Bernasconi

DOI: 10.1021/acs.inorgchem.5b02911

***

A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo

cb-2015-010065_0005
cb-2015-010065_0005

Maruti Uppalapati†, Dong Jun Lee‡, Kalyaneswar Mandal‡, Hongyan Li§, Les P. Miranda∥, Joshua Lowitz, John Kenney, Jarrett J. Adams, Dana Ault-Riché#, Stephen B. H. Kent, and Sachdev S. Sidhu

DOI: 10.1021/acschembio.5b01006

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Catalytic H2O2 Disproportionation and Electrocatalytic O2 Reduction by a Functional Mimic of Heme Catalase: Direct Observation of Compound 0 and Compound I in Situ

cs-2015-02668v_0009
cs-2015-02668v_0009

Kushal Sengupta, Sudipta Chatterjee, and Abhishek Dey

DOI: 10.1021/acscatal.5b02668

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Base-Catalyzed Depolymerization of Biorefinery Lignins

sc-2015-014513_0008
sc-2015-014513_0008

Rui Katahira, Ashutosh Mittal, Kellene McKinney, Xiaowen Chen, Melvin P. Tucker, David K. Johnson, and Gregg T. Beckham

DOI: 10.1021/acssuschemeng.5b01451

***

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