ACS Editors’ Choice: Dengue Virus, Drugs Based on Natural Products, and Arsenic in Groundwater

This week: The medicinal chemistry of dengue virus, natural products as sources for new drugs, dramatic seasonal shifts in groundwater arsensic– and more!

Each and every day, ACS grants free access to a new peer-reviewed research article from one of the Society’s journals. These articles are specially chosen by a team of scientific editors of ACS journals from around the world to highlight the transformative power of chemistry. Access to these articles will remain open to all as a public service.

Check out this week’s picks!

 Selective Imaging of Malignant Ascites in a Mouse Model of Peritoneal Metastasis Using in Vivo Dynamic Nuclear Polarization-Magnetic Resonance Imaging

 

Hinako Eto, Fuminori Hyodo, Kenji Nakano, and Hideo Utsumi

Anal. Chem., Article ASAP

DOI: 10.1021/acs.analchem.5b04821

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Natural Products as Sources of New Drugs from 1981 to 2014

 

David J. Newman and Gordon M. Cragg

Nat. Prod., Article ASAP

DOI: 10.1021/acs.jnatprod.5b01055

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Soluble Dinaphtho[2,3-b:2′,3′-f]thieno[3,2-b]thiophene Derivatives for Solution-Processed Organic Field-Effect Transistors

Masanori SawamotoMyeong Jin KangEigo MiyazakiHiroyoshi SuginoItaru Osaka, and Kazuo Takimiya

ACS Appl. Mater. Interfaces, Article ASAP

DOI: 10.1021/acsami.5b10477

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Aquifer Arsenic Cycling Induced by Seasonal Hydrologic Changes within the Yangtze River Basin

Michael V. Schaefer, Samantha C. Ying, Shawn G. Benner, Yanhua Duan, Yanxin Wang, and Scott Fendorf

Environ. Sci. Technol., Article ASAP

DOI: 10.1021/acs.est.5b04986

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Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma

Keith Biggadike, Mahbub Ahmed, Doug I. Ball, Diane M. Coe, Deidre A. Dalmas Wilk, Chris D. Edwards, Bob H. Gibbon, Charlotte J. Hardy, Stephen A. Hermitage, Joanne O. Hessey, Aimee E. Hillegas, Stephen C. Hughes, Linos Lazarides, Xiao Q. Lewell, Amanda Lucas, David N. Mallett, Mark A. Price, Fiona M. Priest, Diana J. Quint, Poonam Shah, Anesh Sitaram, Stephen A. Smith, Richard Stocker, Naimisha A. Trivedi, Daphne C. Tsitoura, and Victoria Weller

Med. Chem., Article ASAP

DOI: 10.1021/acs.jmedchem.5b01647

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Highly Regio- and Enantioselective Hydroformylation of Vinyl Esters Using Bidentate Phosphine,P-Chiral Phosphorodiamidite Ligands

Christian Schmitz, Katharina Holthusen, Walter Leitner, and Giancarlo Franciò

ACS Catal., 2016, 6, pp 1584–1589

DOI: 10.1021/acscatal.5b02846

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The Medicinal Chemistry of Dengue Virus

jm-2015-01653z_0021

Mira A. M. Behnam, Christoph Nitsche, Veaceslav Boldescu, and Christian D. Klein

Med. Chem., Article ASAP

DOI: 10.1021/acs.jmedchem.5b01653

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If you have comments or questions for the author of this post, please e-mail: Axial@acs.org.