Most-Read Articles of 2016: Analytical Chemistry

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in 2016, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list for 2016, but rather as an interesting perspective on where the chemistry community allocated their attention over the past year.

Of course, certain factors such as publishing earlier in the year, being featured in a special issue or being made open access may influence which items appeared on this list. To that end, ACS Axial will be publishing monthly updates on the most read chemistry articles of 2017 all year long. Don’t see your favorite papers on the list? Feel free to share your picks in the comments below.

Read more most-read articles: Applied | Biological | Materials Science & Engineering | Organic/Inorganic | Physical
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ACS Sensors

Biosensors Based on Two-Dimensional MoS2

ACS Sens., 2016, 1 (1), pp 5–16
DOI: 10.1021/acssensors.5b00142

Aptamer-Modified Graphene-Based Catalytic Micromotors: Off–On Fluorescent Detection of Ricin
(Open Access Through ACS Editors’ Choice)

ACS Sens., 2016, 1 (3), pp 217–221
DOI: 10.1021/acssensors.5b00300

Wearable Microsensor Array for Multiplexed Heavy Metal Monitoring of Body Fluids
(Open Access Through ACS Editors’ Choice)

ACS Sens., 2016, 1 (7), pp 866–874
DOI: 10.1021/acssensors.6b00287

Noninvasive Alcohol Monitoring Using a Wearable Tattoo-Based Iontophoretic-Biosensing System

ACS Sens., 2016, 1 (8), pp 1011–1019
DOI: 10.1021/acssensors.6b00356

Wearable Chemical Sensors: Present Challenges and Future Prospects

ACS Sens., 2016, 1 (5), pp 464–482
DOI: 10.1021/acssensors.6b00250
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Analytical Chemistry

Instrument-Free Point-of-Care Molecular Detection of Zika Virus
(Open Access Through ACS Editors’ Choice)

Anal. Chem., 2016, 88 (14), pp 7289–7294
DOI: 10.1021/acs.analchem.6b01632

Hard Cap Espresso Machines in Analytical Chemistry: What Else?
Open Access Through ACS AuthorChoice

Anal. Chem., 2016, 88 (12), pp 6570–6576
DOI: 10.1021/acs.analchem.6b01400

Fluorescence, Phosphorescence, and Chemiluminescence
This article is part of the Fundamental and Applied Reviews in Analytical Chemistry 2016 special issue.

Anal. Chem., 2016, 88 (1), pp 170–202
DOI: 10.1021/acs.analchem.5b04109

Toward Merging Untargeted and Targeted Methods in Mass Spectrometry-Based Metabolomics and Lipidomics
This article is part of the Fundamental and Applied Reviews in Analytical Chemistry 2016 special issue.

Anal. Chem., 2016, 88 (1), pp 524–545
DOI: 10.1021/acs.analchem.5b04491

Lab-on-a-Drone: Toward Pinpoint Deployment of Smartphone-Enabled Nucleic Acid-Based Diagnostics for Mobile Health Care
Open Access Through ACS Editors’ Choice

Anal. Chem., 2016, 88 (9), pp 4651–4660
DOI: 10.1021/acs.analchem.5b04153

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Chemical Research in Toxicology

Chemical Composition of Aerosol from an E-Cigarette: A Quantitative Comparison with Cigarette Smoke
Open Access Through ACS AuthorChoice

Chem. Res. Toxicol., 2016, 29 (10), pp 1662–1678
DOI: 10.1021/acs.chemrestox.6b00188

Computational Models for Human and Animal Hepatotoxicity with a Global Application Scope
Open Access Through ACS Editors’ Choice

Chem. Res. Toxicol., 2016, 29 (5), pp 757–767
DOI: 10.1021/acs.chemrestox.5b00465

Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space
This article is part of the Toxicology Strategies for Drug Discovery – Present and Future special issue.

Chem. Res. Toxicol., 2016, 29 (4), pp 564–616
DOI: 10.1021/acs.chemrestox.6b00043

Hop (Humulus lupulus L.) Extract and 6-Prenylnaringenin Induce P450 1A1 Catalyzed Estrogen 2-Hydroxylation
Open Access Through ACS Editors’ Choice

Chem. Res. Toxicol., 2016, 29 (7), pp 1142–1150
DOI: 10.1021/acs.chemrestox.6b00112

Metabolic Fate of Hallucinogenic NBOMes
Open Access Through ACS AuthorChoice

Chem. Res. Toxicol., 2016, 29 (1), pp 96–100
DOI: 10.1021/acs.chemrestox.5b00450
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Environmental Science & Technology

Emissions of Ultrafine Particles and Volatile Organic Compounds from Commercially Available Desktop Three-Dimensional Printers with Multiple Filaments
Open Access Through ACS AuthorChoice

Environ. Sci. Technol., 2016, 50 (3), pp 1260–1268
DOI: 10.1021/acs.est.5b04983

Plastic Debris Is a Human Health Issue
Environ. Sci. Technol., 2016, 50 (13), pp 6825–6826
DOI: 10.1021/acs.est.6b02569

Regional Effects of Agricultural Conservation Practices on Nutrient Transport in the Upper Mississippi River Basin
Open Access Through ACS AuthorChoice

Environ. Sci. Technol., 2016, 50 (13), pp 6991–7000
DOI: 10.1021/acs.est.5b03543

Personal Vehicles Evaluated against Climate Change Mitigation Targets
Open Access Through ACS AuthorChoice

Environ. Sci. Technol., 2016, 50 (20), pp 10795–10804
DOI: 10.1021/acs.est.6b00177

Progressive Increase in Disinfection Byproducts and Mutagenicity from Source to Tap to Swimming Pool and Spa Water: Impact of Human Inputs

Environ. Sci. Technol., 2016, 50 (13), pp 6652–6662
DOI: 10.1021/acs.est.6b00808
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Environmental Science & Technology Letters

Detection of Poly- and Perfluoroalkyl Substances (PFASs) in U.S. Drinking Water Linked to Industrial Sites, Military Fire Training Areas, and Wastewater Treatment Plants
Open Access Through ACS Editors’ Choice

Environ. Sci. Technol. Lett., 2016, 3 (10), pp 344–350
DOI: 10.1021/acs.estlett.6b00260

Toward Microcapsule-Embedded Self-Healing Membranes
Open Access Through ACS Editors’ Choice

Environ. Sci. Technol. Lett., 2016, 3 (5), pp 216–221
DOI: 10.1021/acs.estlett.6b00046

Origin of Hexavalent Chromium in Drinking Water Wells from the Piedmont Aquifers of North Carolina
Open Access Through ACS Editors’ Choice

Environ. Sci. Technol. Lett., 2016, 3 (12), pp 409–414
DOI: 10.1021/acs.estlett.6b00342

Metformin and Other Pharmaceuticals Widespread in Wadeable Streams of the Southeastern United States
Open Access Through ACS AuthorChoice

Environ. Sci. Technol. Lett., 2016, 3 (6), pp 243–249
DOI: 10.1021/acs.estlett.6b00170

The Critical Need for Increased Selectivity, Not Increased Water Permeability, for Desalination Membranes
Open Access Through ACS AuthorChoice

Environ. Sci. Technol. Lett., 2016, 3 (4), pp 112–120
DOI: 10.1021/acs.estlett.6b00050
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Journal of the American Chemical Society

Practical Ni-Catalyzed Aryl–Alkyl Cross-Coupling of Secondary Redox-Active Esters

Open Access Through ACS AuthorChoice
J. Am. Chem. Soc., 2016, 138 (7), pp 2174–2177
DOI: 10.1021/jacs.6b00250

Radicals: Reactive Intermediates with Translational Potential
Open Access Through ACS AuthorChoice

J. Am. Chem. Soc., 2016, 138 (39), pp 12692–12714
DOI: 10.1021/jacs.6b08856

11-Step Total Synthesis of (−)-Maoecrystal V
Open Access Through ACS AuthorChoice

J. Am. Chem. Soc., 2016, 138 (30), pp 9425–9428
DOI: 10.1021/jacs.6b06623

Emerging Frontiers in Drug Delivery

J. Am. Chem. Soc., 2016, 138 (3), pp 704–717
DOI: 10.1021/jacs.5b09974

11-Step Total Synthesis of Pallambins C and D
Open Access Through ACS AuthorChoice

J. Am. Chem. Soc., 2016, 138 (24), pp 7536–7539
DOI: 10.1021/jacs.6b04816

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Journal of Agricultural and Food Chemistry

Determination of Glyphosate Levels in Breast Milk Samples from Germany by LC-MS/MS and GC-MS/MS
Open Access Through ACS AuthorChoice

J. Agric. Food Chem., 2016, 64 (6), pp 1414–1421
DOI: 10.1021/acs.jafc.5b05852

Antioxidant Mechanism of Betaine without Free Radical Scavenging Ability
Open Access Through ACS AuthorChoice

J. Agric. Food Chem., 2016, 64 (42), pp 7921–7930
DOI: 10.1021/acs.jafc.6b03592

Nanoencapsulation, Nano-guard for Pesticides: A New Window for Safe Application

J. Agric. Food Chem., 2016, 64 (7), pp 1447–1483
DOI: 10.1021/acs.jafc.5b05214

Sulfoglucosides as Novel Modified Forms of the Mycotoxins Alternariol and Alternariol Monomethyl Ether
Open Access Through ACS AuthorChoice

J. Agric. Food Chem., 2016, 64 (46), pp 8892–8901
DOI: 10.1021/acs.jafc.6b03120

Global Adoption of Genetically Modified (GM) Crops: Challenges for the Public Sector

J. Agric. Food Chem., 2016, 64 (2), pp 394–402
DOI: 10.1021/acs.jafc.5b05116

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Journal of Chemical Education

Strategies of Successful Synthesis Solutions: Mapping, Mechanisms, and More
Open Access Through ACS Editors’ Choice

J. Chem. Educ., 2016, 93 (4), pp 593–604
DOI: 10.1021/acs.jchemed.5b00900

Investigating Students’ Reasoning about Acid–Base Reactions
Open Access Through ACS AuthorChoice

J. Chem. Educ., 2016, 93 (10), pp 1703–1712
DOI: 10.1021/acs.jchemed.6b00417

Deducing Reaction Mechanism: A Guide for Students, Researchers, and Instructors

J. Chem. Educ., 2016, 93 (2), pp 275–286
DOI: 10.1021/acs.jchemed.5b00160

Building a Microcontroller Based Potentiostat: A Inexpensive and Versatile Platform for Teaching Electrochemistry and Instrumentation

J. Chem. Educ., 2016, 93 (7), pp 1320–1322
DOI: 10.1021/acs.jchemed.5b00961

RCSB Protein Data Bank: A Resource for Chemical, Biochemical, and Structural Explorations of Large and Small Biomolecules
This article is part of the Chemical Information special issue.

J. Chem. Educ., 2016, 93 (3), pp 569–575
DOI: 10.1021/acs.jchemed.5b00404
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Journal of Proteome Research

Proteomics Quality Control: Quality Control Software for MaxQuant Results
This article is part of the Large-Scale Computational Mass Spectrometry and Multi-Omics special issue.
Open Access Through ACS Editors’ Choice

J. Proteome Res., 2016, 15 (3), pp 777–787
DOI: 10.1021/acs.jproteome.5b00780

Unbiased Metabolomic Investigation of Alzheimer’s Disease Brain Points to Dysregulation of Mitochondrial Aspartate Metabolism
Open Access Through ACS AuthorChoice

J. Proteome Res., 2016, 15 (2), pp 608–618
DOI: 10.1021/acs.jproteome.5b01020

A Proteomics Approach to the Protein Normalization Problem: Selection of Unvarying Proteins for MS-Based Proteomics and Western Blotting
Open Access Through ACS AuthorChoice

J. Proteome Res., 2016, 15 (7), pp 2321–2326
DOI: 10.1021/acs.jproteome.6b00403

Accounting for the Multiple Natures of Missing Values in Label-Free Quantitative Proteomics Data Sets to Compare Imputation Strategies
Open Access Through ACS AuthorChoice

J. Proteome Res., 2016, 15 (4), pp 1116–1125
DOI: 10.1021/acs.jproteome.5b00981

moCluster: Identifying Joint Patterns Across Multiple Omics Data Sets
This article is part of the Large-Scale Computational Mass Spectrometry and Multi-Omics special issue.
Open Access Through ACS Editors’ Choice

J. Proteome Res., 2016, 15 (3), pp 755–765
DOI: 10.1021/acs.jproteome.5b00824
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Read more most-read articles:  Applied | Biological | Materials Science & Engineering | Organic/Inorganic | Physical

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