Discover the Most Read Organic/Inorganic Chemistry Articles of Jan. 2017

What were chemists reading in January of 2017? To find out, we’ve compiled lists of the five most-read organic and inorganic chemistry articles that appeared in each a chemistry ACS Publications journal in January 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Analytical Chemistry | Applied Chemistry| Biological Chemistry| Materials Science & Engineering | Multidisciplinary Journals | Physical Chemistry |
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ACS Catalysis

Catalysis by Supported Single Metal Atoms
ACS Catal., 2017, 7 (1), pp 34–59
DOI: 10.1021/acscatal.6b01534

Predicting a Breakthrough Year for ACS Catalysis
ACS Catal., 2017, 7 (1), pp 919–919
DOI: 10.1021/acscatal.6b03629

Photoelectrocatalytic Water Splitting: Significance of Cocatalysts, Electrolyte, and Interfaces
ACS Catal., 2017, 7 (1), pp 675–688
DOI: 10.1021/acscatal.6b03107

Electrochemical Ammonia Synthesis—The Selectivity Challenge
ACS Catal., 2017, 7 (1), pp 706–709
DOI: 10.1021/acscatal.6b03035

Recent Advances in Transition-Metal-Catalyzed Synthetic Transformations of Organosilicon Reagents
ACS Catal., 2017, 7 (1), pp 631–651
DOI: 10.1021/acscatal.6b02374

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ACS Combinatorial Science

Expediting Combinatorial Data Set Analysis by Combining Human and Algorithmic Analysis
Open Access Through Editors’ Choice
ACS Comb. Sci., 2017, 19 (1), pp 1–8
DOI: 10.1021/acscombsci.6b00151

Automated Phase Mapping with AgileFD and its Application to Light Absorber Discovery in the V–Mn–Nb Oxide System
Open Access Through Editors’ Choice
ACS Comb. Sci., 2017, 19 (1), pp 37–46
DOI: 10.1021/acscombsci.6b00153

Chemoselective Coupling Preserves the Substrate Integrity of Surface-Immobilized Oligonucleotides for Emulsion PCR-Based Gene Library Construction
ACS Comb. Sci., 2017, 19 (1), pp 9–14
DOI: 10.1021/acscombsci.6b00146

Fast Optimization of LiMgMnOx/La2O3 Catalysts for the Oxidative Coupling of Methane
ACS Comb. Sci., 2017, 19 (1), pp 15–24
DOI: 10.1021/acscombsci.6b00108

Using Similarity Metrics to Quantify Differences in High-Throughput Data Sets: Application to X-ray Diffraction Patterns
ACS Comb. Sci., 2017, 19 (1), pp 25–36
DOI: 10.1021/acscombsci.6b00142

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ACS Medicinal Chemistry Letters

Great Therapeutic Potential of Peptidylarginine Deiminase 4 (PAD4) Inhibitors: Treatment of Rheumatoid Arthritis, Epigenetic Tools, Regulation of Pluripotency in Stem Cells, and More
ACS Med. Chem. Lett., 2017, 8 (1), pp 19–21
DOI: 10.1021/acsmedchemlett.6b00515

Systematic Study of Effects of Structural Modifications on the Aqueous Solubility of Drug-like Molecules
ACS Med. Chem. Lett., 2017, 8 (1), pp 124–127
DOI: 10.1021/acsmedchemlett.6b00451

ACS Medicinal Chemistry Letters: Technology Notes
ACS Med. Chem. Lett., 2017, 8 (1), pp 1–2
DOI: 10.1021/acsmedchemlett.6b00484

Viral Replication Inhibitors May Treat the Dengue Virus Infections
ACS Med. Chem. Lett., 2017, 8 (1), pp 14–16
DOI: 10.1021/acsmedchemlett.6b00513

Potential Treatment of Cognitive Impairment in Schizophrenia by Phosphodiesterase 2 (PDE2) Inhibitors
ACS Med. Chem. Lett., 2017, 8 (1), pp 17–18
DOI: 10.1021/acsmedchemlett.6b00514

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Bioconjugate Chemistry

New Advances in Nanotechnology-Based Diagnosis and Therapeutics for Breast Cancer: An Assessment of Active-Targeting Inorganic Nanoplatforms
This article is part of the Interfacing Inorganic Nanoparticles with Biology special issue.
Bioconjugate Chem., 2017, 28 (1), pp 135–152
DOI: 10.1021/acs.bioconjchem.6b00591

Interfacing Inorganic Nanoparticles with Biology
This article is part of the Interfacing Inorganic Nanoparticles with Biology special issue.
Bioconjugate Chem., 2017, 28 (1), pp 1–2
DOI: 10.1021/acs.bioconjchem.6b00727

Characterizing Self-Assembled Monolayers on Gold Nanoparticles
Open Access Through ACS AuthorChoice
This article is part of the Interfacing Inorganic Nanoparticles with Biology special issue.
Bioconjugate Chem., 2017, 28 (1), pp 11–22
DOI: 10.1021/acs.bioconjchem.6b00587

Biointerfacing and Applications of Cell Membrane-Coated Nanoparticles
This article is part of the Interfacing Inorganic Nanoparticles with Biology special issue.
Bioconjugate Chem., 2017, 28 (1), pp 23–32
DOI: 10.1021/acs.bioconjchem.6b00569

Current Challenges toward In Vitro Cellular Validation of Inorganic Nanoparticles
Open Access Through ACS Editors’ Choice

This article is part of the Interfacing Inorganic Nanoparticles with Biology special issue.

Bioconjugate Chem., 2017, 28 (1), pp 212–221
DOI: 10.1021/acs.bioconjchem.6b00514

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Inorganic Chemistry

High CO2 Uptake Capacity and Selectivity in a Fascinating Nanotube-Based Metal–Organic Framework
Inorg. Chem., 2017, 56 (2), pp 908–913
DOI: 10.1021/acs.inorgchem.6b02491

Editorial: Inorganic Chemistry at 55
Inorg. Chem., 2017, 56 (1), pp 102–105
DOI: 10.1021/acs.inorgchem.6b03018

A General Strategy for Ligand Exchange on Upconversion Nanoparticles
Inorg. Chem., 2017, 56 (2), pp 872–877
DOI: 10.1021/acs.inorgchem.6b02479

Anion–Cation Mediated Structural Rearrangement of an In-derived Three-Dimensional Interpenetrated Metal–Organic Framework
Inorg. Chem., 2017, 56 (2), pp 950–955
DOI: 10.1021/acs.inorgchem.6b02584

Efficient Synthesis of Tris-Heteroleptic Iridium(III) Complexes Based on the Zn2+-Promoted Degradation of Tris-Cyclometalated Iridium(III) Complexes and Their Photophysical Properties
Inorg. Chem., 2017, 56 (2), pp 812–833
DOI: 10.1021/acs.inorgchem.6b02270

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Journal of Medicinal Chemistry

A Versatile Method to Determine the Cellular Bioavailability of Small-Molecule Inhibitors
Open Access Through ACS Editors’ Choice
J. Med. Chem., 2017, 60 (1), pp 157–169
DOI: 10.1021/acs.jmedchem.6b00923

Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept
J. Med. Chem., 2017, 60 (2), pp 797–804
DOI: 10.1021/acs.jmedchem.6b01691

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
J. Med. Chem., 2017, 60 (2), pp 767–786
DOI: 10.1021/acs.jmedchem.6b01634

Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K)

J. Med. Chem., 2017, 60 (2), pp 627–640
DOI: 10.1021/acs.jmedchem.6b01363

Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach
J. Med. Chem., 2017, 60 (2), pp 608–626
DOI: 10.1021/acs.jmedchem.6b01007

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Journal of Natural Products

α-Glucosidase Inhibitors from Malbranchea flavorosea
J. Nat. Prod., 2017, 80 (1), pp 190–195
DOI: 10.1021/acs.jnatprod.6b00977

Octaminomycins A and B, Cyclic Octadepsipeptides Active against Plasmodium falciparum
J. Nat. Prod., 2017, 80 (1), pp 134–140
DOI: 10.1021/acs.jnatprod.6b00758

Antibacterial and Cytotoxic Phenolic Metabolites from the Fruits of Amorpha fruticosa
J. Nat. Prod., 2017, 80 (1), pp 169–180
DOI: 10.1021/acs.jnatprod.6b00809

Nanomolar Antimalarial Agents against Chloroquine-Resistant Plasmodium falciparum from Medicinal Plants and Their Structure–Activity Relationships
J. Nat. Prod., 2017, 80 (1), pp 96–107
DOI: 10.1021/acs.jnatprod.6b00744

Thiol-Based Probe for Electrophilic Natural Products Reveals That Most of the Ammosamides Are Artifacts
J. Nat. Prod., 2017, 80 (1), pp 126–133
DOI: 10.1021/acs.jnatprod.6b00773

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The Journal of Organic Chemistry

Burgess Reagent Facilitated Alcohol Oxidations in DMSO
J. Org. Chem., 2017, 82 (2), pp 1046–1052
DOI: 10.1021/acs.joc.6b02629

Asymmetric Total Syntheses of (−)-Hedycoropyrans A and B
J. Org. Chem., 2017, 82 (2), pp 1127–1135
DOI: 10.1021/acs.joc.6b02738

Asymmetric Total Syntheses of Two Possible Diastereomers of Gliomasolide E and Its Structural Elucidation
J. Org. Chem., 2017, 82 (2), pp 1053–1063
DOI: 10.1021/acs.joc.6b02611

Palladium-Catalyzed, ortho-Selective C–H Halogenation of Benzyl Nitriles, Aryl Weinreb Amides, and Anilides
J. Org. Chem., 2017, 82 (2), pp 1114–1126
DOI: 10.1021/acs.joc.6b02731

Visible-Light-Induced Direct Difluoroalkylation of Uracils, Pyridinones, and Coumarins
J. Org. Chem., 2017, 82 (2), pp 910–917
DOI: 10.1021/acs.joc.6b02316

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Molecular Pharmaceutics

Improving Therapeutic Potential of Farnesylthiosalicylic Acid: Tumor Specific Delivery via Conjugation with Heptamethine Cyanine Dye
Mol. Pharmaceutics, 2017, 14 (1), pp 1–13
DOI: 10.1021/acs.molpharmaceut.5b00906

Improved Micellar Formulation for Enhanced Delivery for Paclitaxel
Mol. Pharmaceutics, 2017, 14 (1), pp 31–41
DOI: 10.1021/acs.molpharmaceut.6b00581

Targeted Biomimetic Nanoparticles for Synergistic Combination Chemotherapy of Paclitaxel and Doxorubicin
Mol. Pharmaceutics, 2017, 14 (1), pp 107–123
DOI: 10.1021/acs.molpharmaceut.6b00732

NIR Light-Activated Drug Release for Synergetic Chemo–Photothermal Therapy
Mol. Pharmaceutics, 2017, 14 (1), pp 242–251
DOI: 10.1021/acs.molpharmaceut.6b00820

Long-Term Physical Stability of PVP- and PVPVA-Amorphous Solid Dispersions
Mol. Pharmaceutics, 2017, 14 (1), pp 157–171
DOI: 10.1021/acs.molpharmaceut.6b00763

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Organic Letters

Enantioselective Total Synthesis of (+)-Sieboldine A
Open Access Through ACS Editors’ Choice
Org. Lett., 2017, 19 (2), pp 320–323
DOI: 10.1021/acs.orglett.6b03416

Transition-Metal-Free Lactonization of sp2 C–H Bonds with CO2
Org. Lett., 2017, 19 (2), pp 396–399
DOI: 10.1021/acs.orglett.6b03601

Pd-Catalyzed Intramolecular Aminoalkylation of Unactivated Alkenes: Access to Diverse N-Heterocycles
Org. Lett., 2017, 19 (2), pp 308–311
DOI: 10.1021/acs.orglett.6b03295

Total Synthesis of Pyrrole–Imidazole Alkaloid (+)-Cylindradine B
Org. Lett., 2017, 19 (2), pp 420–423
DOI: 10.1021/acs.orglett.6b03722

Diamination/Oxidative Cross-Coupling/Bicyclization of Anilines and Methyl Ketones: Direct I2-Promoted Synthesis of 1,2-Fused Oxindoles
Org. Lett., 2017, 19 (2), pp 408–411
DOI: 10.1021/acs.orglett.6b03636

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Organic Process Research & Development

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2017, 21 (1), pp 1–10
DOI: 10.1021/acs.oprd.6b00440

Pilot Scale Process Development of SL65.0102-10, an N-Diazabicyclo[2.2.2]-octylmethyl Benzamide
Org. Process Res. Dev., 2017, 21 (1), pp 18–22
DOI: 10.1021/acs.oprd.6b00262

Methodology for Replacing Dipolar Aprotic Solvents Used in API Processing with Safe Hydrogen-Bond Donor and Acceptor Solvent-Pair Mixtures
Open Access Through ACS AuthorChoice
Org. Process Res. Dev., 2017, 21 (1), pp 114–124
DOI: 10.1021/acs.oprd.6b00401

Development of a Modified Process for the Kilogram-Scale Synthesis of c-Met/ALK Inhibitor HS-10168
Org. Process Res. Dev., 2017, 21 (1), pp 133–137
DOI: 10.1021/acs.oprd.6b00402

Development and Scale-up of a Biocatalytic Process To Form a Chiral Sulfoxide
Org. Process Res. Dev., 2017, 21 (1), pp 107–113
DOI: 10.1021/acs.oprd.6b00391

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Organometallics

Selective Iron-Catalyzed Deaminative Hydrogenation of Amides
Organometallics, 2017, 36 (2), pp 409–416
DOI: 10.1021/acs.organomet.6b00816

Sequential Addition of Phosphine to Alkynes for the Selective Synthesis of 1,2-Diphosphinoethanes under Catalysis. Well-Defined NHC-Copper Phosphides vs in Situ CuCl2/NHC Catalyst
Organometallics, 2017, 36 (2), pp 455–459
DOI: 10.1021/acs.organomet.6b00854

A Photoswitchable Olefin Metathesis Catalyst
Organometallics, 2017, 36 (2), pp 490–497
DOI: 10.1021/acs.organomet.6b00913

Nickel-Catalyzed Coupling of Carbon Dioxide with Cyclohexene Oxide by Well-Characterized Bis(N-Heterocyclic Carbene) Carbazolide Complexes
Organometallics, 2017, 36 (2), pp 291–297
DOI: 10.1021/acs.organomet.6b00756

Oligomerization of Ethylene Using a Diphosphine Palladium Catalyst
Organometallics, 2017, 36 (2), pp 443–447
DOI: 10.1021/acs.organomet.6b00850

If you have comments or questions for the author of this post, please e-mail: Axial@acs.org.