Discover the Most-Read Organic/Inorganic Chemistry Articles of Feb. 2017

What were chemists reading in February of 2017? To find out, we’ve compiled lists of the five most-read organic and inorganic chemistry articles that appeared in each related ACS Publications journal in February 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.
***

ACS Catalysis

A Versatile Disulfide-Driven Recycling System for NADP+ with High Cofactor Turnover Number
Open access through ACS Editors’ Choice
ACS Catal., 2017, 7 (2), pp 1025–1029
DOI: 10.1021/acscatal.6b03061

Visible-Light-Mediated Anti-Markovnikov Hydration of Olefins
Open access through ACS Editors’ Choice
ACS Catal., 2017, 7 (2), pp 1432–1437
DOI: 10.1021/acscatal.6b03388

Breaking Amides using Nickel Catalysis
ACS Catal., 2017, 7 (2), pp 1413–1423
DOI: 10.1021/acscatal.6b03277

Metal–Metal Bonds in Catalysis
ACS Catal., 2017, 7 (2), pp 936–958
DOI: 10.1021/acscatal.6b02692

Catalytic Zirconium/Hafnium-Based Metal–Organic Frameworks
ACS Catal., 2017, 7 (2), pp 997–1014
DOI: 10.1021/acscatal.6b02923

***

ACS Combinatorial Science

Synthesis of Novel 5,6-Disubstituted Pyrrolo [2,3-d]Pyrimidine-2,4-Diones Via One-Pot Three-Component Reactions
ACS Comb. Sci., 2017, 19 (2), pp 108–112
DOI: 10.1021/acscombsci.6b00147

Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer’s Disease
ACS Comb. Sci., 2017, 19 (2), pp 55–80
DOI: 10.1021/acscombsci.6b00116

Neural-Network-Biased Genetic Algorithms for Materials Design: Evolutionary Algorithms That Learn
ACS Comb. Sci., 2017, 19 (2), pp 96–107
DOI: 10.1021/acscombsci.6b00136

Combining a Ru(II) “Building Block” and Rapid Screening Approach to Identify DNA Structure-Selective “Light Switch” Compounds
ACS Comb. Sci., 2017, 19 (2), pp 85–95
DOI: 10.1021/acscombsci.6b00119

Fluorophore Metal–Organic Complexes: High-Throughput Optical Screening for Aprotic Electrochemical Systems
ACS Comb. Sci., 2017, 19 (2), pp 81–84
DOI: 10.1021/acscombsci.6b00171

***

ACS Medicinal Chemistry Letters

Communicating Our Science to Our Customers: Drug Discovery in Five Simple Experiments.
ACS Med. Chem. Lett., 2017, 8 (2), pp 143–144
DOI: 10.1021/acsmedchemlett.7b00015

Intramolecular Hydrogen Bond Expectations in Medicinal Chemistry
ACS Med. Chem. Lett., 2017, 8 (2), pp 139–142
DOI: 10.1021/acsmedchemlett.7b00002

Design and Synthesis of Novel, Selective GPR40 AgoPAMs
ACS Med. Chem. Lett., 2017, 8 (2), pp 221–226
DOI: 10.1021/acsmedchemlett.6b00443

Discovery of Novel, Orally Bioavailable β-Amino Acid Azaindole Inhibitors of Influenza PB2
ACS Med. Chem. Lett., 2017, 8 (2), pp 256–260
DOI: 10.1021/acsmedchemlett.6b00486

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors
ACS Med. Chem. Lett., 2017, 8 (2), pp 239–244
DOI: 10.1021/acsmedchemlett.6b00464

***

Bioconjugate Chemistry

Quantitative Conjugated Payload Measurement Using Enzymatic Release of Antibody–Drug Conjugate with Cleavable Linker
Bioconjugate Chem., 2017, 28 (2), pp 620–626
DOI: 10.1021/acs.bioconjchem.6b00695

Peptide-Based Stealth Nanoparticles for Targeted and pH-Triggered Delivery
Bioconjugate Chem., 2017, 28 (2), pp 627–635
DOI: 10.1021/acs.bioconjchem.6b00701

Investigation of Hydrophilic Auristatin Derivatives for Use in Antibody Drug Conjugates
Bioconjugate Chem., 2017, 28 (2), pp 371–381
DOI: 10.1021/acs.bioconjchem.6b00530

Enhanced G-Quadruplex DNA Stabilization and Telomerase Inhibition by Novel Fluorescein Derived Salen and Salphen Based Ni(II) and Pd(II) Complexes
Bioconjugate Chem., 2017, 28 (2), pp 341–352
DOI: 10.1021/acs.bioconjchem.6b00433

Automated, Resin-Based Method to Enhance the Specific Activity of Fluorine-18 Clicked PET Radiotracers
Bioconjugate Chem., 2017, 28 (2), pp 583–589
DOI: 10.1021/acs.bioconjchem.6b00678

***

Inorganic Chemistry

Activating Fe(I) Porphyrins for the Hydrogen Evolution Reaction Using Second-Sphere Proton Transfer Residues
Inorg. Chem., 2017, 56 (4), pp 1783–1793
DOI: 10.1021/acs.inorgchem.6b01707

Bifunctional Imidazolium-Based Ionic Liquid Decorated UiO-67 Type MOF for Selective CO2 Adsorption and Catalytic Property for CO2 Cycloaddition with Epoxides
Inorg. Chem., 2017, 56 (4), pp 2337–2344
DOI: 10.1021/acs.inorgchem.6b03169

Green Synthesis of Zr-CAU-28: Structure and Properties of the First Zr-MOF Based on 2,5-Furandicarboxylic Acid
Inorg. Chem., 2017, 56 (4), pp 2270–2277
DOI: 10.1021/acs.inorgchem.6b02969

Photoluminescent and Slow Magnetic Relaxation Studies on Lanthanide(III)-2,5-pyrazinedicarboxylate Frameworks
Inorg. Chem., 2017, 56 (4), pp 2108–2123
DOI: 10.1021/acs.inorgchem.6b02774

Water-Stable In(III)-Based Metal–Organic Frameworks with Rod-Shaped Secondary Building Units: Single-Crystal to Single-Crystal Transformation and Selective Sorption of C2H2 over CO2 and CH4
Inorg. Chem., 2017, 56 (4), pp 2188–2197
DOI: 10.1021/acs.inorgchem.6b02840

***

Journal of Medicinal Chemistry

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases
J. Med. Chem., 2017, 60 (4), pp 1247–1261
DOI: 10.1021/acs.jmedchem.6b01751

Recent Advances in Scaffold Hopping
J. Med. Chem., 2017, 60 (4), pp 1238–1246
DOI: 10.1021/acs.jmedchem.6b01437

Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions
J. Med. Chem., 2017, 60 (3), pp 839–885
DOI: 10.1021/acs.jmedchem.6b00788

Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A
J. Med. Chem., 2017, 60 (3), pp 1000–1017
DOI: 10.1021/acs.jmedchem.6b01329

Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker
J. Med. Chem., 2017, 60 (3), pp 1060–1075
DOI: 10.1021/acs.jmedchem.6b01460

***

Journal of Natural Products

Diterpenoids and Lignans from Cephalotaxus fortunei
J. Nat. Prod., 2017, 80 (2), pp 356–362
DOI: 10.1021/acs.jnatprod.6b00802

Concise Syntheses of Hyrtioreticulins C and D via a C-4 Pictet–Spengler Reaction: Revised Signs of Specific Rotations
J. Nat. Prod., 2017, 80 (2), pp 241–245
DOI: 10.1021/acs.jnatprod.7b00008

Branimycins B and C, Antibiotics Produced by the Abyssal Actinobacterium Pseudonocardia carboxydivorans M-227
J. Nat. Prod., 2017, 80 (2), pp 569–573
DOI: 10.1021/acs.jnatprod.6b01107

Cultures of the Marine Bacterium Pseudovibrio denitrificans Ab134 Produce Bromotyrosine-Derived Alkaloids Previously Only Isolated from Marine Sponges
J. Nat. Prod., 2017, 80 (2), pp 235–240
DOI: 10.1021/acs.jnatprod.6b00838

Sesquiterpenoids with Various Carbocyclic Skeletons from the Flowers of Chrysanthemum indicum
J. Nat. Prod., 2017, 80 (2), pp 298–307
DOI: 10.1021/acs.jnatprod.6b00694

***

The Journal of Organic Chemistry

Chlorophyll-Catalyzed Visible-Light-Mediated Synthesis of Tetrahydroquinolines from N,N-Dimethylanilines and Maleimides
Open access through ACS Editors’ Choice
J. Org. Chem., 2017, 82 (4), pp 1888–1894
DOI: 10.1021/acs.joc.6b03034

Visible-Light-Induced C2 Alkylation of Pyridine N-Oxides
J. Org. Chem., 2017, 82 (4), pp 2059–2066
DOI: 10.1021/acs.joc.6b02891

Photoredox-Assisted Reductive Cross-Coupling: Mechanistic Insight into Catalytic Aryl–Alkyl Cross-Couplings
J. Org. Chem., 2017, 82 (4), pp 1996–2003
DOI: 10.1021/acs.joc.6b02830

Synthesis of Rings DEF of Solanoeclepin A
J. Org. Chem., 2017, 82 (4), pp 2045–2058
DOI: 10.1021/acs.joc.6b02886

Synthesis of 5H-Dibenzo[c,e]azepine-5,7(6H)-diones from Benzamides via Palladium-Catalyzed Double C–H Bond Activation
J. Org. Chem., 2017, 82 (4), pp 2288–2293
DOI: 10.1021/acs.joc.6b03087

***

Molecular Pharmaceutics

Polymer–Drug Nanoparticles Combine Doxorubicin Carrier and Heparin Bioactivity Functionalities for Primary and Metastatic Cancer Treatment
Mol. Pharmaceutics, 2017, 14 (2), pp 513–522
DOI: 10.1021/acs.molpharmaceut.6b00979

Measurement of in vivo Gastrointestinal Release and Dissolution of Three Locally Acting Mesalamine Formulations in Regions of the Human Gastrointestinal Tract
Mol. Pharmaceutics, 2017, 14 (2), pp 345–358
DOI: 10.1021/acs.molpharmaceut.6b00641

Effect of Particle Size on Drug Loading and Release Kinetics of Gefitinib-Loaded PLGA Microspheres
Mol. Pharmaceutics, 2017, 14 (2), pp 459–467
DOI: 10.1021/acs.molpharmaceut.6b00896

Preclinical Comparison of Albumin-Binding Radiofolates: Impact of Linker Entities on the in Vitro and in Vivo Properties
Mol. Pharmaceutics, 2017, 14 (2), pp 523–532
DOI: 10.1021/acs.molpharmaceut.6b01010

Self-Assembly PEGylation Retaining Activity (SPRA) Technology via a Host–Guest Interaction Surpassing Conventional PEGylation Methods of Proteins
Mol. Pharmaceutics, 2017, 14 (2), pp 368–376
DOI: 10.1021/acs.molpharmaceut.6b00678

***

Organic Letters

Metal-Free C–H Functionalization of Alkanes by Aryldiazoacetates
Org. Lett., 2017, 19 (4), pp 770–773
DOI: 10.1021/acs.orglett.6b03681

Nickel-Catalyzed Stereoselective Alkenylation of C(sp3)–H Bonds with Terminal Alkynes
Org. Lett., 2017, 19 (4), pp 850–853
DOI: 10.1021/acs.orglett.6b03856

Selective C(sp2)–H Halogenation of “Click” 4-Aryl-1,2,3-triazoles
Org. Lett., 2017, 19 (4), pp 962–965
DOI: 10.1021/acs.orglett.7b00275

Enantioselective Synthesis of Cephalimysins B and C
Org. Lett., 2017, 19 (4), pp 750–753
DOI: 10.1021/acs.orglett.6b03373

Isolation and Total Synthesis of Hoshinolactam, an Antitrypanosomal Lactam from a Marine Cyanobacterium
Org. Lett., 2017, 19 (4), pp 890–893
DOI: 10.1021/acs.orglett.7b00047

***

Organic Process Research & Development

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2017, 21 (2), pp 142–152
DOI: 10.1021/acs.oprd.7b00027

In Praise of Short Papers for OPR&D
Org. Process Res. Dev., 2017, 21 (2), pp 141–141
DOI: 10.1021/acs.oprd.7b00012

Green Chemistry Articles of Interest to the Pharmaceutical Industry
Org. Process Res. Dev., 2017, 21 (2), pp 153–164
DOI: 10.1021/acs.oprd.7b00014

Process Development of a CRF1 Receptor Antagonist Based on the Selective Chlorination of a Benzimidazolone via Chlorine Migration
Org. Process Res. Dev., 2017, 21 (2), pp 222–230
DOI: 10.1021/acs.oprd.6b00389

Sustainable and Scalable Fe/ppm Pd Nanoparticle Nitro Group Reductions in Water at Room Temperature
Org. Process Res. Dev., 2017, 21 (2), pp 247–252
DOI: 10.1021/acs.oprd.6b00410

***

Organometallics

Coordination Chemistry and Reactivity of Bis(aldimino)pyridine Nickel Complexes in Four Different Oxidation States
Organometallics, 2017, 36 (3), pp 582–593
DOI: 10.1021/acs.organomet.6b00793

Alkene Isomerization by “Sandwich” Diimine-Palladium Catalysts
Organometallics, 2017, 36 (4), pp 787–790
DOI: 10.1021/acs.organomet.6b00856

Flipping the Oxidation State Formalism: Charge Distribution in Organometallic Complexes As Reported by Carbon Monoxide
Organometallics, 2017, 36 (3), pp 622–631
DOI: 10.1021/acs.organomet.6b00820

Rhenium(I) Triscarbonyl Complexes with Redox-Active Amino- and Iminopyridine Ligands: Metal–Ligand Cooperation as Trigger for the Reversible Binding of CO2 via a Dearmomatization/Rearomatization Reaction Sequence
Organometallics, 2017, 36 (4), pp 839–848
DOI: 10.1021/acs.organomet.6b00897

Hidden Enantioselective Hydrogenation of N-Silyl Enamines and Silyl Enol Ethers in Net C═N and C═O Hydrosilylations Catalyzed by Ru–S Complexes with One Monodentate Chiral Phosphine Ligand
Organometallics, 2017, 36 (4), pp 935–943
DOI: 10.1021/acs.organomet.7b00030