Discover the Most-Read Biological Chemistry Articles of March 2017

What were chemists reading in March of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each biological chemistry ACS Publications journal in March 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read more great March 2017 Chemistry research: Analytical Chemistry | Applied Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Organic/Inorganic Chemistry | Physical Chemistry

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ACS Biomaterials Science & Engineering

Progress and Trends in Artificial Silk Spinning: A Systematic Review
Open access through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2017, 3 (3), pp 226–237
DOI: 10.1021/acsbiomaterials.6b00669

EGFR-Targeted Metal Chelating Polymers (MCPs) Harboring Multiple Pendant PEG2K Chains for MicroPET/CT Imaging of Patient-Derived Pancreatic Cancer Xenografts
Open access through ACS Editors’ Choice
ACS Biomater. Sci. Eng., 2017, 3 (3), pp 279–290
DOI: 10.1021/acsbiomaterials.6b00649

3D Bioprinting of Vessel-like Structures with Multilevel Fluidic Channels
ACS Biomater. Sci. Eng., 2017, 3 (3), pp 399–408
DOI: 10.1021/acsbiomaterials.6b00643

Nanogel-Integrated pH-Responsive Composite Hydrogels for Controlled Drug Delivery
ACS Biomater. Sci. Eng., 2017, 3 (3), pp 370–380
DOI: 10.1021/acsbiomaterials.6b00670

Membrane Pore Spacing Can Modulate Endothelial Cell–Substrate and Cell–Cell Interactions
ACS Biomater. Sci. Eng., 2017, 3 (3), pp 243–248
DOI: 10.1021/acsbiomaterials.7b00055

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ACS Catalysis

Superlative Scientific Writing
ACS Catal., 2017, 7 (3), pp 2218–2219
DOI: 10.1021/acscatal.7b00566

A Viewpoint on Chemical Reductions of Carbon–Oxygen Bonds in Renewable Feedstocks Including CO2 and Biomass
ACS Catal., 2017, 7 (3), pp 2107–2115
DOI: 10.1021/acscatal.6b03581

Electrochemical Reduction of CO2 Catalyzed by Fe-N-C Materials: A Structure–Selectivity Study
ACS Catal., 2017, 7 (3), pp 1520–1525
DOI: 10.1021/acscatal.6b03353

Silver-Catalyzed Anti-Markovnikov Hydroxyfluorination of Styrenes
ACS Catal., 2017, 7 (3), pp 1606–1609
DOI: 10.1021/acscatal.6b03529

Ruthenium-Catalyzed Direct Hydroxymethylation of Aryl C–H Bonds
ACS Catal., 2017, 7 (3), pp 2213–2217
DOI: 10.1021/acscatal.7b00078

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ACS Chemical Biology

The Ecstasy and Agony of Assay Interference Compounds
ACS Chem. Biol., 2017, 12 (3), pp 575–578
DOI: 10.1021/acschembio.7b00119

Tools for Studying Glycans: Recent Advances in Chemoenzymatic Glycan Labeling
ACS Chem. Biol., 2017, 12 (3), pp 611–621
DOI: 10.1021/acschembio.6b01089

Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases
Open access through ACS Editors’ Choice
ACS Chem. Biol., 2017, 12 (3), pp 852–861
DOI: 10.1021/acschembio.6b01052

Subcellular Redox Targeting: Bridging in Vitro and in Vivo Chemical Biology
ACS Chem. Biol., 2017, 12 (3), pp 586–600
DOI: 10.1021/acschembio.6b01148

Highly Constrained Bicyclic Scaffolds for the Discovery of Protease-Stable Peptides via mRNA Display
ACS Chem. Biol., 2017, 12 (3), pp 795–804
DOI: 10.1021/acschembio.6b01006

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ACS Chemical Neuroscience

N-Terminal Hypothesis for Alzheimer’s Disease
ACS Chem. Neurosci., 2017, 8 (3), pp 432–434
DOI: 10.1021/acschemneuro.7b00037

Role of Academic Drug Discovery in the Quest for New CNS Therapeutics
ACS Chem. Neurosci., 2017, 8 (3), pp 429–431
DOI: 10.1021/acschemneuro.7b00040

Role of Academic Drug Discovery in the Quest for New CNS Therapeutics
ACS Chem. Neurosci., 2017, 8 (3), pp 429–431
DOI: 10.1021/acschemneuro.7b00040

The Ecstasy and Agony of Assay Interference Compounds
ACS Chem. Neurosci., 2017, 8 (3), pp 420–423
DOI: 10.1021/acschemneuro.7b00064

Heteromer Induction: An Approach to Unique Pharmacology?
ACS Chem. Neurosci., 2017, 8 (3), pp 426–428
DOI: 10.1021/acschemneuro.7b00002

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ACS Infectious Diseases

Rational Design of Single-Chain Polymeric Nanoparticles That Kill Planktonic and Biofilm Bacteria
ACS Infect. Dis., 2017, 3 (3), pp 237–248
DOI: 10.1021/acsinfecdis.6b00203

Optimization and Synthesis of Pyridazinone Derivatives as Novel Inhibitors of Hepatitis B Virus by Inducing Genome-free Capsid Formation
ACS Infect. Dis., 2017, 3 (3), pp 199–205
DOI: 10.1021/acsinfecdis.6b00159

Pseudomonas aeruginosa LasR·DNA Binding Is Directly Inhibited by Quorum Sensing Antagonists
ACS Infect. Dis., 2017, 3 (3), pp 183–189
DOI: 10.1021/acsinfecdis.6b00163

Antimicrobial Activity, AME Resistance, and A-Site Binding Studies of Anthraquinone–Neomycin Conjugates
ACS Infect. Dis., 2017, 3 (3), pp 206–215
DOI: 10.1021/acsinfecdis.6b00176

A Sensitive in Vitro High-Throughput Screen To Identify Pan-filoviral Replication Inhibitors Targeting the VP35–NP Interface
ACS Infect. Dis., 2017, 3 (3), pp 190–198
DOI: 10.1021/acsinfecdis.6b00209

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ACS Medicinal Chemistry Letters

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin
Open access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2017, 8 (3), pp 321–326
DOI: 10.1021/acsmedchemlett.6b00491

Curcumin May Defy Medicinal Chemists
ACS Med. Chem. Lett., 2017, 8 (3), pp 274–274
DOI: 10.1021/acsmedchemlett.7b00051

Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites
Open access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2017, 8 (3), pp 350–354
DOI: 10.1021/acsmedchemlett.7b00011

Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach
ACS Med. Chem. Lett., 2017, 8 (3), pp 338–343
DOI: 10.1021/acsmedchemlett.6b00519

Editorial: Medicinal Chemistry Research in India
ACS Med. Chem. Lett., 2017, 8 (3), pp 270–272
DOI: 10.1021/acsmedchemlett.7b00064

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ACS Synthetic Biology

Polyketide Bioderivatization Using the Promiscuous Acyltransferase KirCII
ACS Synth. Biol., 2017, 6 (3), pp 421–427
DOI: 10.1021/acssynbio.6b00341

Introducing Our Authors
ACS Synth. Biol., 2017, 6 (3), pp 382–387
DOI: 10.1021/acssynbio.7b00067

A Simple Combinatorial Codon Mutagenesis Method for Targeted Protein Engineering
ACS Synth. Biol., 2017, 6 (3), pp 416–420
DOI: 10.1021/acssynbio.6b00297

Synthetic Core Promoters as Universal Parts for Fine-Tuning Expression in Different Yeast Species
Open access through ACS AuthorChoice
ACS Synth. Biol., 2017, 6 (3), pp 471–484
DOI: 10.1021/acssynbio.6b00178

Development of a Transcription Factor-Based Lactam Biosensor
ACS Synth. Biol., 2017, 6 (3), pp 439–445
DOI: 10.1021/acssynbio.6b00136

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Biochemistry

The Cation−π Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification
Open access through ACS Editors’ Choice
Biochemistry, 2017, 56 (11), pp 1585–1595
DOI: 10.1021/acs.biochem.7b00056

The Discovery of a β-Lactone Synthetase
Biochemistry, 2017, 56 (9), pp 1175–1176
DOI: 10.1021/acs.biochem.7b00061

The Ecstasy and Agony of Assay Interference Compounds
Biochemistry, 2017, 56 (10), pp 1363–1366
DOI: 10.1021/acs.biochem.7b00110

Through the Lipopolysaccharide Glass: A Potent Antimicrobial Peptide Induces Phase Changes in Membranes
Biochemistry, 2017, 56 (11), pp 1672–1679
DOI: 10.1021/acs.biochem.6b01063

Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition between α-Synuclein Species
Biochemistry, 2017, 56 (9), pp 1177–1180
DOI: 10.1021/acs.biochem.6b01178

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Bioconjugate Chemistry

Peptide Conjugates for Biological Applications
Open access through ACS AuthorChoice
Bioconjugate Chem., 2017, 28 (3), pp 689–690
DOI: 10.1021/acs.bioconjchem.7b00102

Designing Hybrid Antibiotic Peptide Conjugates To Cross Bacterial Membranes
Bioconjugate Chem., 2017, 28 (3), pp 793–804
DOI: 10.1021/acs.bioconjchem.6b00725

Functional Modification of Thioether Groups in Peptides, Polypeptides, and Proteins
Bioconjugate Chem., 2017, 28 (3), pp 691–700
DOI: 10.1021/acs.bioconjchem.6b00696

Self-Assembly of Peptide Bioconjugates: Selected Recent Research Highlights
Open access through ACS AuthorChoice
Bioconjugate Chem., 2017, 28 (3), pp 731–739
DOI: 10.1021/acs.bioconjchem.6b00284

Site-Specific and Stoichiometric Stealth Polymer Conjugates of Therapeutic Peptides and Proteins
Bioconjugate Chem., 2017, 28 (3), pp 713–723
DOI: 10.1021/acs.bioconjchem.6b00652

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Biomacromolecules

Stimuli-Responsive Polymersomes for Biomedical Applications
Biomacromolecules, 2017, 18 (3), pp 649–673
DOI: 10.1021/acs.biomac.6b01704

Nonswelling Click-Cross-Linked Gelatin and PEG Hydrogels with Tunable Properties Using Pluronic Linkers
Biomacromolecules, 2017, 18 (3), pp 757–766
DOI: 10.1021/acs.biomac.6b01601

Metal Ion Mediated Cellulose Nanofibrils Transient Network in Covalently Cross-linked Hydrogels: Mechanistic Insight into Morphology and Dynamics
Biomacromolecules, 2017, 18 (3), pp 1019–1028
DOI: 10.1021/acs.biomac.6b01915

Complexes of Magnetic Nanoparticles with Cellulose Nanocrystals as Regenerable, Highly Efficient, and Selective Platform for Protein Separation
Biomacromolecules, 2017, 18 (3), pp 898–905
DOI: 10.1021/acs.biomac.6b01778

In Vivo Imaging of the Stability and Sustained Cargo Release of an Injectable Amphipathic Peptide-Based Hydrogel
Biomacromolecules, 2017, 18 (3), pp 994–1001
DOI: 10.1021/acs.biomac.6b01840

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Journal of Agricultural and Food Chemistry

Nitrogen-to-Protein Conversion Factors for Three Edible Insects: Tenebrio molitor, Alphitobius diaperinus, and Hermetia illucens
Open access through ACS AuthorChoice
J. Agric. Food Chem., 2017, 65 (11), pp 2275–2278
DOI: 10.1021/acs.jafc.7b00471

Arsenic Release from Foodstuffs upon Food Preparation
J. Agric. Food Chem., 2017, 65 (11), pp 2443–2453
DOI: 10.1021/acs.jafc.6b05721

Functional Characterization of a New Tea (Camellia sinensis) Flavonoid Glycosyltransferase
J. Agric. Food Chem., 2017, 65 (10), pp 2074–2083
DOI: 10.1021/acs.jafc.6b05619

Various Bioactivity and Relationship of Structure–Activity of Matrine Analogues
J. Agric. Food Chem., 2017, 65 (10), pp 2039–2047
DOI: 10.1021/acs.jafc.6b05474

New LC-MS/MS Method for the Analysis of Allura Red Level in Takeaway Chinese Dishes and Urine of an Adult Chinese Population
J. Agric. Food Chem., 2017, 65 (12), pp 2588–2593
DOI: 10.1021/acs.jafc.6b05310

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Journal of Chemical Theory and Computation

Comparison of Implicit and Explicit Solvent Models for the Calculation of Solvation Free Energy in Organic Solvents
J. Chem. Theory Comput., 2017, 13 (3), pp 1034–1043
DOI: 10.1021/acs.jctc.7b00169

Gaussian-Based Coupled-Cluster Theory for the Ground-State and Band Structure of Solids
J. Chem. Theory Comput., 2017, 13 (3), pp 1209–1218
DOI: 10.1021/acs.jctc.7b00049

Fragment-Based Approach for the Evaluation of NMR Chemical Shifts for Large Biomolecules Incorporating the Effects of the Solvent Environment
J. Chem. Theory Comput., 2017, 13 (3), pp 1147–1158
DOI: 10.1021/acs.jctc.6b00922

Combining the MARTINI and Structure-Based Coarse-Grained Approaches for the Molecular Dynamics Studies of Conformational Transitions in Proteins
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2017, 13 (3), pp 1366–1374
DOI: 10.1021/acs.jctc.6b00986

Modeling Protein Conformational Transition Pathways Using Collective Motions and the LASSO Method
J. Chem. Theory Comput., 2017, 13 (3), pp 1401–1410
DOI: 10.1021/acs.jctc.6b01110

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Journal of Medicinal Chemistry

The Essential Medicinal Chemistry of Curcumin
Open access through ACS Editors’ Choice
J. Med. Chem., 2017, 60 (5), pp 1620–1637
DOI: 10.1021/acs.jmedchem.6b00975

How Big Is Too Big for Cell Permeability?
J. Med. Chem., 2017, 60 (5), pp 1662–1664
DOI: 10.1021/acs.jmedchem.7b00237

The Ecstasy and Agony of Assay Interference Compounds
J. Med. Chem., 2017, 60 (6), pp 2165–2168
DOI: 10.1021/acs.jmedchem.7b00229

Combining Molecular Scaffolds from FDA Approved Drugs: Application to Drug Discovery
J. Med. Chem., 2017, 60 (5), pp 1638–1647
DOI: 10.1021/acs.jmedchem.6b01367

Design, Synthesis, and Evaluation of a Novel Series of Oxadiazine Gamma Secretase Modulators for Familial Alzheimer’s Disease
J. Med. Chem., 2017, 60 (6), pp 2383–2400
DOI: 10.1021/acs.jmedchem.6b01620

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Journal of Natural Products

Fungal Identification Using Molecular Tools: A Primer for the Natural Products Research Community
Open access through ACS AuthorChoice
J. Nat. Prod., 2017, 80 (3), pp 756–770
DOI: 10.1021/acs.jnatprod.6b01085

The Bengamides: A Mini-Review of Natural Sources, Analogues, Biological Properties, Biosynthetic Origins, and Future Prospects
Open access through ACS Editors’ Choice
J. Nat. Prod., 2017, 80 (3), pp 740–755
DOI: 10.1021/acs.jnatprod.6b00970

Antineoplastic Agents. 603. Quinstatins: Exceptional Cancer Cell Growth Inhibitors
Open access through ACS Editors’ Choice
J. Nat. Prod., 2017, 80 (3), pp 692–698
DOI: 10.1021/acs.jnatprod.6b01006

Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-anthropoidal Mammalian Microbiomes
Open access through ACS AuthorChoice
J. Nat. Prod., 2017, 80 (3), pp 598–608
DOI: 10.1021/acs.jnatprod.6b00772

Protoxenicins A and B, Cytotoxic Long-Chain Acylated Xenicanes from the Soft Coral Protodendron repens
This article is part of the Special Issue in Honor of Phil Crews special issue.
J. Nat. Prod., 2017, 80 (3), pp 713–719
DOI: 10.1021/acs.jnatprod.7b00046

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The Journal of Physical Chemistry B

Evolutionary Covariance Combined with Molecular Dynamics Predicts a Framework for Allostery in the MutS DNA Mismatch Repair Protein
Open access through ACS Editors’ Choice
J. Phys. Chem. B, 2017, 121 (9), pp 2049–2061
DOI: 10.1021/acs.jpcb.6b11976

Beyond the Hofmeister Series: Ion-Specific Effects on Proteins and Their Biological Functions
J. Phys. Chem. B, 2017, 121 (9), pp 1997–2014
DOI: 10.1021/acs.jpcb.6b10797

Conformational Ensembles of the Wild-Type and S8C Aβ1–42 Dimers
J. Phys. Chem. B, 2017, 121 (11), pp 2434–2442
DOI: 10.1021/acs.jpcb.7b00267

Excited-State Proton Transfer in Indigo
J. Phys. Chem. B, 2017, 121 (10), pp 2308–2318
DOI: 10.1021/acs.jpcb.6b11020

Drastic Compensation of Electronic and Solvation Effects on ATP Hydrolysis Revealed through Large-Scale QM/MM Simulations Combined with a Theory of Solutions
J. Phys. Chem. B, 2017, 121 (10), pp 2279–2287
DOI: 10.1021/acs.jpcb.7b00637

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The Journal of Physical Chemistry Letters

Stabilization of the Perovskite Phase of Formamidinium Lead Triiodide by Methylammonium, Cs, and/or Rb Doping
J. Phys. Chem. Lett., 2017, 8 (6), pp 1191–1196
DOI: 10.1021/acs.jpclett.6b03014

Quantitative Phase-Change Thermodynamics and Metastability of Perovskite-Phase Cesium Lead Iodide
J. Phys. Chem. Lett., 2017, 8 (6), pp 1278–1282
DOI: 10.1021/acs.jpclett.7b00134

Probing the Intrinsic Thermal and Photochemical Stability of Hybrid and Inorganic Lead Halide Perovskites
J. Phys. Chem. Lett., 2017, 8 (6), pp 1211–1218
DOI: 10.1021/acs.jpclett.6b03026

Spotlights: Volume 8, Issue 5
J. Phys. Chem. Lett., 2017, 8 (5), pp 1093–1093
DOI: 10.1021/acs.jpclett.7b00429

Decreasing Radiative Recombination Coefficients via an Indirect Band Gap in Lead Halide Perovskites
J. Phys. Chem. Lett., 2017, 8 (6), pp 1265–1271
DOI: 10.1021/acs.jpclett.7b00236

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Journal of Proteome Research

Deep Coverage of Global Protein Expression and Phosphorylation in Breast Tumor Cell Lines Using TMT 10-plex Isobaric Labeling
J. Proteome Res., 2017, 16 (3), pp 1121–1132
DOI: 10.1021/acs.jproteome.6b00374

MALDI versus ESI: The Impact of the Ion Source on Peptide Identification
J. Proteome Res., 2017, 16 (3), pp 1207–1215
DOI: 10.1021/acs.jproteome.6b00805

Expanding Proteome Coverage with CHarge Ordered Parallel Ion aNalysis (CHOPIN) Combined with Broad Specificity Proteolysis
Open access through ACS AuthorChoice
J. Proteome Res., 2017, 16 (3), pp 1288–1299
DOI: 10.1021/acs.jproteome.6b00915

Peptide Selection for Targeted Protein Quantitation
J. Proteome Res., 2017, 16 (3), pp 1376–1380
DOI: 10.1021/acs.jproteome.6b00115

Integrated, High-Throughput, Multiomics Platform Enables Data-Driven Construction of Cellular Responses and Reveals Global Drug Mechanisms of Action
J. Proteome Res., 2017, 16 (3), pp 1364–1375
DOI: 10.1021/acs.jproteome.6b01004

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Molecular Pharmaceutics

Breast Cancer Targeting Peptide Binds Keratin 1: A New Molecular Marker for Targeted Drug Delivery to Breast Cancer
Mol. Pharmaceutics, 2017, 14 (3), pp 593–604
DOI: 10.1021/acs.molpharmaceut.6b00652

Mitochondria and Nucleus Dual Delivery System To Overcome DOX Resistance
Mol. Pharmaceutics, 2017, 14 (3), pp 746–756
DOI: 10.1021/acs.molpharmaceut.6b01016

Antibody-Targeted Cyclodextrin-Based Nanoparticles for siRNA Delivery in the Treatment of Acute Myeloid Leukemia: Physicochemical Characteristics, in Vitro Mechanistic Studies, and ex Vivo Patient Derived Therapeutic Efficacy
Mol. Pharmaceutics, 2017, 14 (3), pp 940–952
DOI: 10.1021/acs.molpharmaceut.6b01150

Recent Advances in Nonlinear Optical Analyses of Pharmaceutical Materials in the Solid State
Mol. Pharmaceutics, 2017, 14 (3), pp 555–565
DOI: 10.1021/acs.molpharmaceut.6b00809

Biocompatible Reduction and pH Dual-Responsive Core Cross-Linked Micelles Based on Multifunctional Amphiphilic Linear–Hyperbranched Copolymer for Controlled Anticancer Drug Delivery
Mol. Pharmaceutics, 2017, 14 (3), pp 799–807
DOI: 10.1021/acs.molpharmaceut.6b01051

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Read more great March 2017 Chemistry research: Analytical Chemistry | Applied Chemistry | Biological Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Organic/Inorganic Chemistry | Physical Chemistry

If you have comments or questions for the author of this post, please e-mail: Axial@acs.org.