Discover the Most-Read Biological Chemistry Articles of April 2017

What were chemists reading in April of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each biological chemistry ACS Publications journal in April 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read more great April 2017 Chemistry Research:

Analytical Chemistry | Applied Chemistry |  Materials Science & Engineering | Multidisciplinary Chemistry | Organic/Inorganic Chemistry | Physical Chemistry

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ACS Biomaterials Science & Engineering

Metal-Chelation-Assisted Deposition of Polydopamine on Human Hair: A Ready-to-Use Eumelanin-Based Hair Dyeing Methodology
Open access through ACS Editors’ Choice
ACS Biomater. Sci. Eng., 2017, 3 (4), pp 628–636
DOI: 10.1021/acsbiomaterials.7b00031

Bioconjugation of Gold Nanobipyramids for SERS Detection and Targeted Photothermal Therapy in Breast Cancer
Open access through ACS Editors’ Choice
ACS Biomater. Sci. Eng., 2017, 3 (4), pp 608–618
DOI: 10.1021/acsbiomaterials.7b00021

Display of DNA on Nanoparticles for Targeting Antigen Presenting Cells
ACS Biomater. Sci. Eng., 2017, 3 (4), pp 496–501
DOI: 10.1021/acsbiomaterials.7b00148

Chitosan Microgels Embedded with Catalase Nanozyme-Loaded Mesocellular Silica Foam for Glucose-Responsive Drug Delivery
ACS Biomater. Sci. Eng., 2017, 3 (4), pp 572–578
DOI: 10.1021/acsbiomaterials.6b00716

From Microfluidic Paper-Based Analytical Devices to Paper-Based Biofluidics with Integrated Continuous Perfusion
ACS Biomater. Sci. Eng., 2017, 3 (4), pp 601–607
DOI: 10.1021/acsbiomaterials.7b00084

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ACS Catalysis

Prior Submission to Alternate Journals Does Not Negatively Affect the Outcome of Submissions to ACS Catalysis
ACS Catal., 2017, 7 (4), pp 3049–3049
DOI: 10.1021/acscatal.7b00984

The Degree of Rate Control: A Powerful Tool for Catalysis Research
ACS Catal., 2017, 7 (4), pp 2770–2779
DOI: 10.1021/acscatal.7b00115

Catalytic Conversion of Alcohols to Carboxylic Acid Salts and Hydrogen with Alkaline Water
ACS Catal., 2017, 7 (4), pp 2786–2790
DOI: 10.1021/acscatal.6b03259

Recent Advances in Catalytic C(sp2)–H Allylation Reactions
ACS Catal., 2017, 7 (4), pp 2821–2847
DOI: 10.1021/acscatal.7b00159

Photoredox-Mediated Routes to Radicals: The Value of Catalytic Radical Generation in Synthetic Methods Development
ACS Catal., 2017, 7 (4), pp 2563–2575
DOI: 10.1021/acscatal.7b00094

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ACS Chemical Biology

Proteolysis-Targeting Chimeras: Induced Protein Degradation as a Therapeutic Strategy
ACS Chem. Biol., 2017, 12 (4), pp 892–898
DOI: 10.1021/acschembio.6b01068

A Near-Infrared, Wavelength-Shiftable, Turn-on Fluorescent Probe for the Detection and Imaging of Cancer Tumor Cells
ACS Chem. Biol., 2017, 12 (4), pp 1121–1132
DOI: 10.1021/acschembio.6b01094

Identifying Functional Cysteine Residues in the Mitochondria
ACS Chem. Biol., 2017, 12 (4), pp 947–957
DOI: 10.1021/acschembio.6b01074

Chemoproteomic Screening of Covalent Ligands Reveals UBA5 As a Novel Pancreatic Cancer Target
ACS Chem. Biol., 2017, 12 (4), pp 899–904
DOI: 10.1021/acschembio.7b00020

A Fluorescent Probe Distinguishes between Inhibition of Early and Late Steps of Lipopolysaccharide Biogenesis in Whole Cells
ACS Chem. Biol., 2017, 12 (4), pp 928–932
DOI: 10.1021/acschembio.7b00159

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ACS Chemical Neuroscience

Neurotoxicity of β-Keto Amphetamines: Deathly Mechanisms Elicited by Methylone and MDPV in Human Dopaminergic SH-SY5Y Cells
ACS Chem. Neurosci., 2017, 8 (4), pp 850–859
DOI: 10.1021/acschemneuro.6b00421

In Vivo Systems Response Profiling and Multivariate Classification of CNS Active Compounds: A Structured Tool for CNS Drug Discovery
Open access through ACS AuthorChoice
ACS Chem. Neurosci., 2017, 8 (4), pp 785–797
DOI: 10.1021/acschemneuro.6b00371

Inhibition and Degradation of Amyloid Beta (Aβ40) Fibrillation by Designed Small Peptide: A Combined Spectroscopy, Microscopy, and Cell Toxicity Study
ACS Chem. Neurosci., 2017, 8 (4), pp 718–722
DOI: 10.1021/acschemneuro.6b00349

Targeting Brain-Eating Amoebae Infections
ACS Chem. Neurosci., 2017, 8 (4), pp 687–688
DOI: 10.1021/acschemneuro.7b00049

Are Dopamine Oxidation Metabolites Involved in the Loss of Dopaminergic Neurons in the Nigrostriatal System in Parkinson’s Disease?
ACS Chem. Neurosci., 2017, 8 (4), pp 702–711
DOI: 10.1021/acschemneuro.7b00034

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ACS Infectious Diseases

Nonwoven Polymer Nanofiber Coatings That Inhibit Quorum Sensing in Staphylococcus aureus: Toward New Nonbactericidal Approaches to Infection Control
ACS Infect. Dis., 2017, 3 (4), pp 271–280
DOI: 10.1021/acsinfecdis.6b00173

The Ecstasy and Agony of Assay Interference Compounds
ACS Infect. Dis., 2017, 3 (4), pp 259–262
DOI: 10.1021/acsinfecdis.7b00023

Aryl-alkyl-lysines: Membrane-Active Fungicides That Act against Biofilms of Candida albicans
ACS Infect. Dis., 2017, 3 (4), pp 293–301
DOI: 10.1021/acsinfecdis.6b00192

Molecular Recognition of Muramyl Dipeptide Occurs in the Leucine-rich Repeat Domain of Nod2
ACS Infect. Dis., 2017, 3 (4), pp 264–270
DOI: 10.1021/acsinfecdis.6b00154

Whole-Cell-Based Assay To Evaluate Structure Permeation Relationships for Carbapenem Passage through the Pseudomonas aeruginosa Porin OprD
ACS Infect. Dis., 2017, 3 (4), pp 310–319
DOI: 10.1021/acsinfecdis.6b00197

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ACS Medicinal Chemistry Letters

Integrated Platform for Expedited Synthesis–Purification–Testing of Small Molecule Libraries
ACS Med. Chem. Lett., 2017, 8 (4), pp 461–465
DOI: 10.1021/acsmedchemlett.7b00054

The Ecstasy and Agony of Assay Interference Compounds
ACS Med. Chem. Lett., 2017, 8 (4), pp 379–382
DOI: 10.1021/acsmedchemlett.7b00056

Pyrano[2,3,4-cd]indole as a Scaffold for Selective Nonbasic 5-HT6R Ligands
ACS Med. Chem. Lett., 2017, 8 (4), pp 390–394
DOI: 10.1021/acsmedchemlett.6b00482

Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase
Open access through ACS AuthorChoice
ACS Med. Chem. Lett., 2017, 8 (4), pp 438–442
DOI: 10.1021/acsmedchemlett.7b00030

Discovery of [1,2,3]Triazolo[4,5-d]pyrimidine Derivatives as Novel LSD1 Inhibitors
ACS Med. Chem. Lett., 2017, 8 (4), pp 384–389
DOI: 10.1021/acsmedchemlett.6b00423

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ACS Synthetic Biology

A New Era of Genome Integration—Simply Cut and Paste!
ACS Synth. Biol., 2017, 6 (4), pp 601–609
DOI: 10.1021/acssynbio.6b00331

Engineering a Thermostable Keto Acid Decarboxylase Using Directed Evolution and Computationally Directed Protein Design
ACS Synth. Biol., 2017, 6 (4), pp 610–618
DOI: 10.1021/acssynbio.6b00240

Effect of Genomic Integration Location on Heterologous Protein Expression and Metabolic Engineering in E. coli
ACS Synth. Biol., 2017, 6 (4), pp 710–720
DOI: 10.1021/acssynbio.6b00350

In Vitro Reconstitution and Optimization of the Entire Pathway to Convert Glucose into Fatty Acid
ACS Synth. Biol., 2017, 6 (4), pp 701–709
DOI: 10.1021/acssynbio.6b00348

Introducing Our Authors
ACS Synth. Biol., 2017, 6 (4), pp 593–600
DOI: 10.1021/acssynbio.7b00107

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Biochemistry

Packaged and Free Satellite Tobacco Mosaic Virus (STMV) RNA Genomes Adopt Distinct Conformational States
Open access through ACS Editors’ Choice
Biochemistry, 2017, 56 (16), pp 2175–2183
DOI: 10.1021/acs.biochem.6b01166

Small Molecule and Peptide Recognition of Protein Transmembrane Domains
Biochemistry, 2017, 56 (15), pp 2076–2085
DOI: 10.1021/acs.biochem.6b00909

Caging and Photoactivation in Single-Molecule Förster Resonance Energy Transfer Experiments
Open access through ACS AuthorChoice
Biochemistry, 2017, 56 (14), pp 2031–2041
DOI: 10.1021/acs.biochem.6b00916

Binding of Thioflavin-T to Amyloid Fibrils Leads to Fluorescence Self-Quenching and Fibril Compaction
Biochemistry, 2017, 56 (16), pp 2170–2174
DOI: 10.1021/acs.biochem.7b00035

Replication Protein A Prohibits Diffusion of the PCNA Sliding Clamp along Single-Stranded DNA
Open access through ACS Editors’ Choice
Biochemistry, 2017, 56 (13), pp 1824–1835
DOI: 10.1021/acs.biochem.6b01213

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Bioconjugate Chemistry

Targeted Diazotransfer Reagents Enable Selective Modification of Proteins with Azides
Open access through ACS AuthorChoice
Bioconjugate Chem., 2017, 28 (4), pp 913–917
DOI: 10.1021/acs.bioconjchem.7b00110

In Vivo Delivery of CRISPR/Cas9 for Therapeutic Gene Editing: Progress and Challenges
Bioconjugate Chem., 2017, 28 (4), pp 880–884
DOI: 10.1021/acs.bioconjchem.7b00057

Apo E-Functionalization of Solid Lipid Nanoparticles Enhances Brain Drug Delivery: Uptake Mechanism and Transport Pathways
Bioconjugate Chem., 2017, 28 (4), pp 995–1004
DOI: 10.1021/acs.bioconjchem.6b00705

Site-Specific Dual Functionalization of Cysteine Residue in Peptides and Proteins with 2-Azidoacrylates
Open access through ACS Editors’ Choice
Bioconjugate Chem., 2017, 28 (4), pp 897–902
DOI: 10.1021/acs.bioconjchem.7b00024

Oligonucleotides Containing Aminated 2′-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA
Bioconjugate Chem., 2017, 28 (4), pp 1214–1220
DOI: 10.1021/acs.bioconjchem.7b00061

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Biomacromolecules

Facile Access to Multisensitive and Self-Healing Hydrogels with Reversible and Dynamic Boronic Ester and Disulfide Linkages
Biomacromolecules, 2017, 18 (4), pp 1356–1364
DOI: 10.1021/acs.biomac.7b00089

Recent Developments in the Synthesis of Biomacromolecules and their Conjugates by Single Electron Transfer–Living Radical Polymerization
Open access through ACS Editors’ Choice
Biomacromolecules, 2017, 18 (4), pp 1039–1063
DOI: 10.1021/acs.biomac.7b00197

Polymerization-Induced Self-Assembly (PISA) – Control over the Morphology of 19F-Containing Polymeric Nano-objects for Cell Uptake and Tracking
Biomacromolecules, 2017, 18 (4), pp 1145–1156
DOI: 10.1021/acs.biomac.6b01788

Ultrasound-Mediated Self-Healing Hydrogels Based on Tunable Metal–Organic Bonding
Biomacromolecules, 2017, 18 (4), pp 1162–1171
DOI: 10.1021/acs.biomac.6b01841

Development of Liver Decellularized Extracellular Matrix Bioink for Three-Dimensional Cell Printing-Based Liver Tissue Engineering
Biomacromolecules, 2017, 18 (4), pp 1229–1237
DOI: 10.1021/acs.biomac.6b01908

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Journal of Agricultural and Food Chemistry

Rare Sugar Syrup Containing d-Allulose but Not High-Fructose Corn Syrup Maintains Glucose Tolerance and Insulin Sensitivity Partly via Hepatic Glucokinase Translocation in Wistar Rats
Open access through ACS Editors’ Choice
J. Agric. Food Chem., 2017, 65 (13), pp 2888–2894
DOI: 10.1021/acs.jafc.6b05627

Retraction of “Antioxidative and Antiinflammatory Activities of Asiatic Acid, Glycyrrhizic Acid, and Oleanolic Acid in Human Bronchial Epithelial Cells”
J. Agric. Food Chem., 2017, 65 (15), pp 3251–3251
DOI: 10.1021/acs.jafc.7b01473

Analysis of 100-Year-Old Beer Originated from the Czech Republic
J. Agric. Food Chem., 2017, 65 (16), pp 3341–3350
DOI: 10.1021/acs.jafc.6b05706

Rapidly Responsive and Highly Selective Fluorescent Probe for Bisulfite Detection in Food
J. Agric. Food Chem., 2017, 65 (13), pp 2883–2887
DOI: 10.1021/acs.jafc.7b00353

Rapid and Simultaneous Analysis of 360 Pesticides in Brown Rice, Spinach, Orange, and Potato Using Microbore GC-MS/MS
J. Agric. Food Chem., 2017, 65 (16), pp 3387–3395
DOI: 10.1021/acs.jafc.7b00576

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Journal of Chemical Theory and Computation

Rigidity Theory-Based Approximation of Vibrational Entropy Changes upon Binding to Biomolecules
J. Chem. Theory Comput., 2017, 13 (4), pp 1495–1502
DOI: 10.1021/acs.jctc.7b00014

How Molecular Size Impacts RMSD Applications in Molecular Dynamics Simulations
J. Chem. Theory Comput., 2017, 13 (4), pp 1518–1524
DOI: 10.1021/acs.jctc.7b00028

Accurate Electron Affinities and Orbital Energies of Anions from a Nonempirically Tuned Range-Separated Density Functional Theory Approach
J. Chem. Theory Comput., 2017, 13 (4), pp 1656–1666
DOI: 10.1021/acs.jctc.6b01249

Quantifying Allosteric Communication via Both Concerted Structural Changes and Conformational Disorder with CARDS
J. Chem. Theory Comput., 2017, 13 (4), pp 1509–1517
DOI: 10.1021/acs.jctc.6b01181

Reparametrization of Protein Force Field Nonbonded Interactions Guided by Osmotic Coefficient Measurements from Molecular Dynamics Simulations
J. Chem. Theory Comput., 2017, 13 (4), pp 1812–1826
DOI: 10.1021/acs.jctc.6b01059

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Journal of Medicinal Chemistry

Determining Cysteines Available for Covalent Inhibition Across the Human Kinome
J. Med. Chem., 2017, 60 (7), pp 2879–2889
DOI: 10.1021/acs.jmedchem.6b01815

Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point
J. Med. Chem., 2017, 60 (8), pp 3438–3450
DOI: 10.1021/acs.jmedchem.7b00267

Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance
J. Med. Chem., 2017, 60 (8), pp 3289–3302
DOI: 10.1021/acs.jmedchem.6b01787

Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors
J. Med. Chem., 2017, 60 (8), pp 3352–3371
DOI: 10.1021/acs.jmedchem.7b00083

Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR
J. Med. Chem., 2017, 60 (7), pp 3002–3019
DOI: 10.1021/acs.jmedchem.6b01894

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Journal of Natural Products

Antibacterial Compounds from Marine Bacteria, 2010–2015
J. Nat. Prod., 2017, 80 (4), pp 1215–1228
DOI: 10.1021/acs.jnatprod.6b00235

Anisucoumaramide, a Bioactive Coumarin from Clausena anisum-olens
J. Nat. Prod., 2017, 80 (4), pp 798–804
DOI: 10.1021/acs.jnatprod.6b00391

The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture
J. Nat. Prod., 2017, 80 (4), pp 1150–1160
DOI: 10.1021/acs.jnatprod.7b00133

Chaunopyran A: Co-Cultivation of Marine Mollusk-Derived Fungi Activates a Rare Class of 2-Alkenyl-Tetrahydropyran
Open access through ACS AuthorChoice
J. Nat. Prod., 2017, 80 (4), pp 1167–1172
DOI: 10.1021/acs.jnatprod.7b00144

Indole Alkaloids from Hunteria zeylanica
J. Nat. Prod., 2017, 80 (4), pp 790–797
DOI: 10.1021/acs.jnatprod.5b01035

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The Journal of Physical Chemistry B

Building a More Predictive Protein Force Field: A Systematic and Reproducible Route to AMBER-FB15
J. Phys. Chem. B, 2017, 121 (16), pp 4023–4039
DOI: 10.1021/acs.jpcb.7b02320

Tribute to Klaus Schulten
J. Phys. Chem. B, 2017, 121 (15), pp 3203–3205
DOI: 10.1021/acs.jpcb.7b02140

The Primary Photochemistry of Vision Occurs at the Molecular Speed Limit
J. Phys. Chem. B, 2017, 121 (16), pp 4040–4047 DOI:10.1021/acs.jpcb.7b02329

Biography of Klaus Schulten
J. Phys. Chem. B, 2017, 121 (15), pp 3206–3206
DOI: 10.1021/acs.jpcb.7b02141

Kinetic Insights into Zn2+-Induced Amyloid β-Protein Aggregation Revealed by Stopped-Flow Fluorescence Spectroscopy
J. Phys. Chem. B, 2017, 121 (16), pp 3909–3917
DOI: 10.1021/acs.jpcb.6b12187

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The Journal of Physical Chemistry Letters

Two-Dimensional Topological Insulators: Progress and Prospects
J. Phys. Chem. Lett., 2017, 8 (8), pp 1905–1919
DOI: 10.1021/acs.jpclett.7b00222

Amine-Based Passivating Materials for Enhanced Optical Properties and Performance of Organic–Inorganic Perovskites in Light-Emitting Diodes
J. Phys. Chem. Lett., 2017, 8 (8), pp 1784–1792
DOI: 10.1021/acs.jpclett.7b00372

Organic–Inorganic Copper(II)-Based Material: A Low-Toxic, Highly Stable Light Absorber for Photovoltaic Application
J. Phys. Chem. Lett., 2017, 8 (8), pp 1804–1809
DOI: 10.1021/acs.jpclett.7b00086

Direct Observation of Charge Collection at Nanometer-Scale Iodide-Rich Perovskites during Halide Exchange Reaction on CH3NH3PbBr3
J. Phys. Chem. Lett., 2017, 8 (8), pp 1724–1728
DOI: 10.1021/acs.jpclett.7b00482

Ultrafast Non-Förster Intramolecular Donor–Acceptor Excitation Energy Transfer
J. Phys. Chem. Lett., 2017, 8 (7), pp 1688–1694
DOI: 10.1021/acs.jpclett.7b00259

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Journal of Proteome Research

Global Post-Translational Modification Discovery
Open access through ACS AuthorChoice
J. Proteome Res., 2017, 16 (4), pp 1383–1390
DOI: 10.1021/acs.jproteome.6b00034

Assessment of Label-Free Quantification in Discovery Proteomics and Impact of Technological Factors and Natural Variability of Protein Abundance
Open access through ACS AuthorChoice
J. Proteome Res., 2017, 16 (4), pp 1410–1424
DOI: 10.1021/acs.jproteome.6b00645

Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo Dragon) by Large-Scale Analyses and De-Novo-Assisted Sequencing Using Electron-Transfer Dissociation Mass Spectrometry
J. Proteome Res., 2017, 16 (4), pp 1470–1482
DOI: 10.1021/acs.jproteome.6b00857

MHC-I Ligand Discovery Using Targeted Database Searches of Mass Spectrometry Data: Implications for T-Cell Immunotherapies
Open access through ACS Editors’ Choice
J. Proteome Res., 2017, 16 (4), pp 1806–1816
DOI: 10.1021/acs.jproteome.6b00971

Deep-Learning-Based Drug–Target Interaction Prediction
J. Proteome Res., 2017, 16 (4), pp 1401–1409
DOI: 10.1021/acs.jproteome.6b00618

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Molecular Pharmaceutics

Biocompatible Injectable Hydrogel with Potent Wound Healing and Antibacterial Properties
Mol. Pharmaceutics, 2017, 14 (4), pp 1218–1230
DOI: 10.1021/acs.molpharmaceut.6b01104

Delivering siRNA and Chemotherapeutic Molecules Across BBB and BTB for Intracranial Glioblastoma Therapy
Mol. Pharmaceutics, 2017, 14 (4), pp 1012–1022
DOI: 10.1021/acs.molpharmaceut.6b00819

Vitamin E Succinate-Grafted-Chitosan Oligosaccharide/RGD-Conjugated TPGS Mixed Micelles Loaded with Paclitaxel for U87MG Tumor Therapy
Mol. Pharmaceutics, 2017, 14 (4), pp 1190–1203
DOI: 10.1021/acs.molpharmaceut.6b01068

Targeted Ultrasound-Triggered Phase Transition Nanodroplets for Her2-Overexpressing Breast Cancer Diagnosis and Gene Transfection
Mol. Pharmaceutics, 2017, 14 (4), pp 984–998
DOI: 10.1021/acs.molpharmaceut.6b00761

Multifunctional Nanoparticles Loading with Docetaxel and GDC0941 for Reversing Multidrug Resistance Mediated by PI3K/Akt Signal Pathway
Mol. Pharmaceutics, 2017, 14 (4), pp 1120–1132
DOI: 10.1021/acs.molpharmaceut.6b01045

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If you have comments or questions for the author of this post, please e-mail: Axial@acs.org.