Discover the Most-Read Organic/Inorganic Chemistry Articles of April 2017

What were chemists reading in April of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each organic chemistry and inorganic chemistry ACS Publications journal in April 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read more great April 2017 Chemistry Research:

Analytical Chemistry | Applied Chemistry | Biological Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Physical Chemistry

***

ACS Catalysis

Prior Submission to Alternate Journals Does Not Negatively Affect the Outcome of Submissions to ACS Catalysis
ACS Catal., 2017, 7 (4), pp 3049–3049
DOI: 10.1021/acscatal.7b00984

The Degree of Rate Control: A Powerful Tool for Catalysis Research
ACS Catal., 2017, 7 (4), pp 2770–2779
DOI: 10.1021/acscatal.7b00115

Catalytic Conversion of Alcohols to Carboxylic Acid Salts and Hydrogen with Alkaline Water
ACS Catal., 2017, 7 (4), pp 2786–2790
DOI: 10.1021/acscatal.6b03259

Recent Advances in Catalytic C(sp2)–H Allylation Reactions
ACS Catal., 2017, 7 (4), pp 2821–2847
DOI: 10.1021/acscatal.7b00159

Photoredox-Mediated Routes to Radicals: The Value of Catalytic Radical Generation in Synthetic Methods Development
ACS Catal., 2017, 7 (4), pp 2563–2575
DOI: 10.1021/acscatal.7b00094

***

ACS Combinatorial Science

Application of Pictet–Spengler Reaction to Indole-Based Alkaloids Containing Tetrahydro-β-carboline Scaffold in Combinatorial Chemistry
ACS Comb. Sci., 2017, 19 (4), pp 199–228
DOI: 10.1021/acscombsci.6b00184

Analysis of Current DNA Encoded Library Screening Data Indicates Higher False Negative Rates for Numerically Larger Libraries
ACS Comb. Sci., 2017, 19 (4), pp 234–238
DOI: 10.1021/acscombsci.7b00023

Diversity-Oriented Synthesis of Coumarin-Linked Benzimidazoles via a One-Pot, Three-Step, Intramolecular Knoevenagel Cyclization
ACS Comb. Sci., 2017, 19 (4), pp 271–275
DOI: 10.1021/acscombsci.7b00004

Evaluating the Effect of Peptoid Lipophilicity on Antimicrobial Potency, Cytotoxicity, and Combinatorial Library Design
ACS Comb. Sci., 2017, 19 (4), pp 229–233
DOI: 10.1021/acscombsci.7b00007

Cellular Uptake Mechanism of Cationic Branched Polypeptides with Poly[l-Lys] Backbone
ACS Comb. Sci., 2017, 19 (4), pp 246–254
DOI: 10.1021/acscombsci.6b00133

***

ACS Medicinal Chemistry Letters

Integrated Platform for Expedited Synthesis–Purification–Testing of Small Molecule Libraries
ACS Med. Chem. Lett., 2017, 8 (4), pp 461–465
DOI: 10.1021/acsmedchemlett.7b00054

The Ecstasy and Agony of Assay Interference Compounds
ACS Med. Chem. Lett., 2017, 8 (4), pp 379–382
DOI: 10.1021/acsmedchemlett.7b00056

Pyrano[2,3,4-cd]indole as a Scaffold for Selective Nonbasic 5-HT6R Ligands
ACS Med. Chem. Lett., 2017, 8 (4), pp 390–394
DOI: 10.1021/acsmedchemlett.6b00482

Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase
Open access through ACS AuthorChoice
ACS Med. Chem. Lett., 2017, 8 (4), pp 438–442
DOI: 10.1021/acsmedchemlett.7b00030

Discovery of [1,2,3]Triazolo[4,5-d]pyrimidine Derivatives as Novel LSD1 Inhibitors
ACS Med. Chem. Lett., 2017, 8 (4), pp 384–389
DOI: 10.1021/acsmedchemlett.6b00423

***

Bioconjugate Chemistry

Targeted Diazotransfer Reagents Enable Selective Modification of Proteins with Azides
Open access through ACS AuthorChoice
Bioconjugate Chem., 2017, 28 (4), pp 913–917
DOI: 10.1021/acs.bioconjchem.7b00110

In Vivo Delivery of CRISPR/Cas9 for Therapeutic Gene Editing: Progress and Challenges
Bioconjugate Chem., 2017, 28 (4), pp 880–884
DOI: 10.1021/acs.bioconjchem.7b00057

Apo E-Functionalization of Solid Lipid Nanoparticles Enhances Brain Drug Delivery: Uptake Mechanism and Transport Pathways
Bioconjugate Chem., 2017, 28 (4), pp 995–1004
DOI: 10.1021/acs.bioconjchem.6b00705

Site-Specific Dual Functionalization of Cysteine Residue in Peptides and Proteins with 2-Azidoacrylates
Open access through ACS Editors’ Choice
Bioconjugate Chem., 2017, 28 (4), pp 897–902
DOI: 10.1021/acs.bioconjchem.7b00024

Oligonucleotides Containing Aminated 2′-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA
Bioconjugate Chem., 2017, 28 (4), pp 1214–1220
DOI: 10.1021/acs.bioconjchem.7b00061

***

Inorganic Chemistry

CO Binding at a Four-Coordinate Cobaltous Porphyrin Site in a Metal–Organic Framework: Structural, EPR, and Gas Adsorption Analysis
Inorg. Chem., 2017, 56 (8), pp 4654–4661
DOI: 10.1021/acs.inorgchem.7b00292

Unprecedented Li+ Exchange in an Anionic Metal–Organic Framework: Significantly Enhanced Gas Uptake Capacity
Inorg. Chem., 2017, 56 (8), pp 4263–4266
DOI: 10.1021/acs.inorgchem.7b00538

Topological Transformation of a Metal–Organic Framework Triggered by Ligand Exchange
Inorg. Chem., 2017, 56 (8), pp 4576–4583
DOI: 10.1021/acs.inorgchem.7b00149

Phosphorescent Decanuclear Bimetallic Pt6M4 (M = Zn, Fe) Tetrahedral Cages
Inorg. Chem., 2017, 56 (8), pp 4258–4262
DOI: 10.1021/acs.inorgchem.7b00501

Synthesis of a NbO Type Homochiral Cu(II) Metal–Organic Framework: Ferroelectric Behavior and Heterogeneous Catalysis of Three-Component Coupling and Pechmann Reactions
Inorg. Chem., 2017, 56 (8), pp 4697–4705
DOI: 10.1021/acs.inorgchem.7b00342

***

Journal of Medicinal Chemistry

Determining Cysteines Available for Covalent Inhibition Across the Human Kinome
J. Med. Chem., 2017, 60 (7), pp 2879–2889
DOI: 10.1021/acs.jmedchem.6b01815

Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point
J. Med. Chem., 2017, 60 (8), pp 3438–3450
DOI: 10.1021/acs.jmedchem.7b00267

Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance
J. Med. Chem., 2017, 60 (8), pp 3289–3302
DOI: 10.1021/acs.jmedchem.6b01787

Discovery and Pre-Clinical Characterization of Third-Generation 4-H Heteroaryldihydropyrimidine (HAP) Analogues as Hepatitis B Virus (HBV) Capsid Inhibitors
J. Med. Chem., 2017, 60 (8), pp 3352–3371
DOI: 10.1021/acs.jmedchem.7b00083

Discovery of N-((3R,4R)-4-Fluoro-1-(6-((3-methoxy-1-methyl-1H-pyrazol-4-yl)amino)-9-methyl-9H-purin-2-yl)pyrrolidine-3-yl)acrylamide (PF-06747775) through Structure-Based Drug Design: A High Affinity Irreversible Inhibitor Targeting Oncogenic EGFR Mutants with Selectivity over Wild-Type EGFR
J. Med. Chem., 2017, 60 (7), pp 3002–3019
DOI: 10.1021/acs.jmedchem.6b01894

***

Journal of Natural Products

Antibacterial Compounds from Marine Bacteria, 2010–2015
J. Nat. Prod., 2017, 80 (4), pp 1215–1228
DOI: 10.1021/acs.jnatprod.6b00235

Anisucoumaramide, a Bioactive Coumarin from Clausena anisum-olens
J. Nat. Prod., 2017, 80 (4), pp 798–804
DOI: 10.1021/acs.jnatprod.6b00391

The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture
J. Nat. Prod., 2017, 80 (4), pp 1150–1160
DOI: 10.1021/acs.jnatprod.7b00133

Chaunopyran A: Co-Cultivation of Marine Mollusk-Derived Fungi Activates a Rare Class of 2-Alkenyl-Tetrahydropyran
Open access through ACS AuthorChoice
J. Nat. Prod., 2017, 80 (4), pp 1167–1172
DOI: 10.1021/acs.jnatprod.7b00144

Indole Alkaloids from Hunteria zeylanica
J. Nat. Prod., 2017, 80 (4), pp 790–797
DOI: 10.1021/acs.jnatprod.5b01035

***

The Journal of Organic Chemistry

Benzimidazoles from Aryl Alkyl Ketones and 2-Amino Anilines by an Iodine Catalyzed Oxidative C(CO)–C(alkyl) Bond Cleavage
J. Org. Chem., 2017, 82 (8), pp 4422–4428
DOI: 10.1021/acs.joc.7b00165

A Systematic Evaluation of the N–F Bond Strength of Electrophilic N–F Reagents: Hints for Atomic Fluorine Donating Ability
J. Org. Chem., 2017, 82 (8), pp 4129–4135
DOI: 10.1021/acs.joc.7b00036

A Total Synthesis of Bifidenone
J. Org. Chem., 2017, 82 (8), pp 4235–4241
DOI: 10.1021/acs.joc.7b00202

Nhatrangin A: Total Syntheses of the Proposed Structure and Six of Its Diastereoisomers
J. Org. Chem., 2017, 82 (8), pp 4072–4112
DOI: 10.1021/acs.joc.6b03060

Reaction Mechanism of Iodine-Catalyzed Michael Additions
J. Org. Chem., 2017, 82 (8), pp 4037–4043
DOI: 10.1021/acs.joc.7b00445

***

Molecular Pharmaceutics

Biocompatible Injectable Hydrogel with Potent Wound Healing and Antibacterial Properties
Mol. Pharmaceutics, 2017, 14 (4), pp 1218–1230
DOI: 10.1021/acs.molpharmaceut.6b01104

Delivering siRNA and Chemotherapeutic Molecules Across BBB and BTB for Intracranial Glioblastoma Therapy
Mol. Pharmaceutics, 2017, 14 (4), pp 1012–1022
DOI: 10.1021/acs.molpharmaceut.6b00819

Vitamin E Succinate-Grafted-Chitosan Oligosaccharide/RGD-Conjugated TPGS Mixed Micelles Loaded with Paclitaxel for U87MG Tumor Therapy
Mol. Pharmaceutics, 2017, 14 (4), pp 1190–1203
DOI: 10.1021/acs.molpharmaceut.6b01068

Targeted Ultrasound-Triggered Phase Transition Nanodroplets for Her2-Overexpressing Breast Cancer Diagnosis and Gene Transfection
Mol. Pharmaceutics, 2017, 14 (4), pp 984–998
DOI: 10.1021/acs.molpharmaceut.6b00761

Multifunctional Nanoparticles Loading with Docetaxel and GDC0941 for Reversing Multidrug Resistance Mediated by PI3K/Akt Signal Pathway
Mol. Pharmaceutics, 2017, 14 (4), pp 1120–1132
DOI: 10.1021/acs.molpharmaceut.6b01045

***

Organic Letters

An Organic Intermolecular Dehydrogenative Annulation Reaction
Org. Lett., 2017, 19 (8), pp 2006–2009
DOI: 10.1021/acs.orglett.7b00562

General and Mild Nickel-Catalyzed Cyanation of Aryl/Heteroaryl Chlorides with Zn(CN)2: Key Roles of DMAP
Org. Lett., 2017, 19 (8), pp 2118–2121
DOI: 10.1021/acs.orglett.7b00732

Stereoselective Photoredox-Catalyzed Chlorotrifluoromethylation of Alkynes: Synthesis of Tetrasubstituted Alkenes
Org. Lett., 2017, 19 (8), pp 1962–1965
DOI: 10.1021/acs.orglett.7b00470

Nickel-Catalyzed Enantioselective Cross-Coupling of N-Hydroxyphthalimide Esters with Vinyl Bromides
Org. Lett., 2017, 19 (8), pp 2150–2153
DOI: 10.1021/acs.orglett.7b00793

Pd(II)-Catalyzed Direct ortho-C–H Acylation of Aromatic Ketones by Oxidative Decarboxylation of α-Oxocarboxylic Acids
Org. Lett., 2017, 19 (8), pp 2082–2085
DOI: 10.1021/acs.orglett.7b00677

***

Organic Process Research & Development

Process Development and Good Manufacturing Practice Production of a Tyrosinase Inhibitor via Titanium-Mediated Coupling between Unprotected Resorcinols and Ketones
Open access through ACS Editors’ Choice
Org. Process Res. Dev., 2017, 21 (4), pp 631–640
DOI: 10.1021/acs.oprd.7b00036

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2017, 21 (4), pp 469–478
DOI: 10.1021/acs.oprd.7b00118

Development and Scale-up of a Flow Chemistry Lithiation–Borylation Route to a Key Boronic Acid Starting Material
Org. Process Res. Dev., 2017, 21 (4), pp 669–673
DOI: 10.1021/acs.oprd.7b00100

Highly Regioselective and Practical Synthesis of 5-Bromo-4-chloro-3-nitro-7-azaindole
Org. Process Res. Dev., 2017, 21 (4), pp 664–668
DOI: 10.1021/acs.oprd.7b00060

Development of Commercial-Ready Processes for Antibody Drug Conjugates
Org. Process Res. Dev., 2017, 21 (4), pp 601–610
DOI: 10.1021/acs.oprd.7b00023

***

Organometallics

Mechanistic Insights into Scandium-Catalyzed Hydroaminoalkylation of Olefins with Amines: Origin of Regioselectivity and Charge-Based Prediction Model
Open access through ACS Editors’ Choice
Organometallics, 2017, 36 (8), pp 1557–1565
DOI: 10.1021/acs.organomet.7b00116

Synthesis, Reactivity, and Catalytic Applications of Isolable (NHC)Cu(CHF2) Complexes
Open access through ACS Editors’ Choice
Organometallics, 2017, 36 (7), pp 1220–1223
DOI: 10.1021/acs.organomet.7b00025

Oxidative Addition of Aryl Electrophiles to a Prototypical Nickel(0) Complex: Mechanism and Structure/Reactivity Relationships
Open access through ACS AuthorChoice
Organometallics, 2017, 36 (8), pp 1662–1672
DOI: 10.1021/acs.organomet.7b00208

Ruthenium PNN(O) Complexes: Cooperative Reactivity and Application as Catalysts for Acceptorless Dehydrogenative Coupling Reactions
Open access through ACS AuthorChoice
Organometallics, 2017, 36 (8), pp 1541–1549
DOI: 10.1021/acs.organomet.7b00111

Selective Actinide-Catalyzed Tandem Proton-Transfer Esterification of Aldehydes with Alcohols for the Production of Asymmetric Esters
Organometallics, 2017, 36 (8), pp 1461–1464
DOI: 10.1021/acs.organomet.7b00101

 

 

 

 

 

 

 

 

If you have comments or questions for the author of this post, please e-mail: Axial@acs.org.