Discover the Most-Read Biological Chemistry Articles of May 2017

What were chemists reading in May of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each biological chemistry ACS Publications journal in May 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great May 2017 Chemistry Research:

Analytical Chemistry | Applied Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Organic/Inorganic Chemistry | Physical Chemistry

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ACS Biomaterials Science & Engineering

3D Printing of a Double Network Hydrogel with a Compression Strength and Elastic Modulus Greater than those of Cartilage
ACS Biomater. Sci. Eng., 2017, 3 (5), pp 863–869
DOI: 10.1021/acsbiomaterials.7b00094

Editorial: Special Issue on Designer Protein Biomaterials
ACS Biomater. Sci. Eng., 2017, 3 (5), pp 658–660
DOI: 10.1021/acsbiomaterials.7b00256

Collagen and Elastin Biomaterials for the Fabrication of Engineered Living Tissues
ACS Biomater. Sci. Eng., 2017, 3 (5), pp 694–711
DOI: 10.1021/acsbiomaterials.6b00250

Scalable Production of Genetically Engineered Nanofibrous Macroscopic Materials via Filtration
ACS Biomater. Sci. Eng., 2017, 3 (5), pp 733–741
DOI: 10.1021/acsbiomaterials.6b00437

Facile Preparation of Delivery Platform of Water-Soluble Low-Molecular-Weight Drugs Based on Polyion Complex Vesicle (PICsome) Encapsulating Mesoporous Silica Nanoparticle
Open access through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2017, 3 (5), pp 807–815
DOI: 10.1021/acsbiomaterials.6b00562

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ACS Catalysis

Announcing the Inaugural ACS Catalysis Early Career Advisory Board
ACS Catal., 2017, 7 (5), pp 3712–3712
DOI: 10.1021/acscatal.7b01261

Supramolecular Photocatalysts for the Reduction of CO2
ACS Catal., 2017, 7 (5), pp 3394–3409
DOI: 10.1021/acscatal.7b00440

Ligand-Promoted Direct C–H Arylation of Simple Arenes: Evidence for a Cooperative Bimetallic Mechanism
Open access through ACS AuthorChoice
ACS Catal., 2017, 7 (5), pp 3336–3343
DOI: 10.1021/acscatal.7b00397

Enhancing Electrocatalytic Activity for Hydrogen Evolution by Strongly Coupled Molybdenum Nitride@Nitrogen-Doped Carbon Porous Nano-Octahedrons
ACS Catal., 2017, 7 (5), pp 3540–3547
DOI: 10.1021/acscatal.7b00120

Isolated Single-Atomic Ru Catalyst Bound on a Layered Double Hydroxide for Hydrogenation of CO2 to Formic Acid
ACS Catal., 2017, 7 (5), pp 3147–3151
DOI: 10.1021/acscatal.7b00312

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ACS Chemical Biology

Reactive Oxygen Species Synergize To Potently and Selectively Induce Cancer Cell Death
ACS Chem. Biol., 2017, 12 (5), pp 1416–1424
DOI: 10.1021/acschembio.7b00015

Introducing Our Authors
ACS Chem. Biol., 2017, 12 (5), pp 1163–1165
DOI: 10.1021/acschembio.7b00372

Rational Redesign of a Functional Protein Kinase-Substrate Interaction
Open access through ACS Editors’ Choice
ACS Chem. Biol., 2017, 12 (5), pp 1194–1198
DOI: 10.1021/acschembio.7b00089

Membrane Oxidation in Cell Delivery and Cell Killing Applications
ACS Chem. Biol., 2017, 12 (5), pp 1170–1182
DOI: 10.1021/acschembio.7b00237

Novel Peptides Derived from Dengue Virus Capsid Protein Translocate Reversibly the Blood–Brain Barrier through a Receptor-Free Mechanism
ACS Chem. Biol., 2017, 12 (5), pp 1257–1268
DOI: 10.1021/acschembio.7b00087

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ACS Chemical Neuroscience

Growing Evidence for Heterogeneous Synaptic Localization of 5-HT2A Receptors
ACS Chem. Neurosci., 2017, 8 (5), pp 897–899
DOI: 10.1021/acschemneuro.6b00409

Serotonergic Approaches in Parkinson’s Disease: Translational Perspectives, an Update
ACS Chem. Neurosci., 2017, 8 (5), pp 973–986
DOI: 10.1021/acschemneuro.6b00440

A Visible-Light-Sensitive Caged Serotonin
ACS Chem. Neurosci., 2017, 8 (5), pp 1036–1042
DOI: 10.1021/acschemneuro.7b00083

Serotonin in Space: Understanding Single Fibers
ACS Chem. Neurosci., 2017, 8 (5), pp 893–896
DOI: 10.1021/acschemneuro.6b00417

A Potential PET Radiotracer for the 5-HT2C Receptor: Synthesis and in Vivo Evaluation of 4-(3-[18F]fluorophenethoxy)pyrimidine
Open access through ACS Editors’ Choice
ACS Chem. Neurosci., 2017, 8 (5), pp 996–1003
DOI: 10.1021/acschemneuro.6b00445

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ACS Infectious Diseases

ACS Infectious Diseases Special Issue Focused on Drug Discovery for Global Health
ACS Infect. Dis., 2017, 3 (5), pp 329–329
DOI: 10.1021/acsinfecdis.7b00050

Biomimetic Bacterial Identification Platform Based on Thermal Wave Transport Analysis (TWTA) through Surface-Imprinted Polymers
Open access through ACS AuthorChoice
ACS Infect. Dis., 2017, 3 (5), pp 388–397
DOI: 10.1021/acsinfecdis.7b00037

A Screen for Protein–Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A
ACS Infect. Dis., 2017, 3 (5), pp 336–348
DOI: 10.1021/acsinfecdis.6b00179

N6′, N6′′′, and O4′ Modifications to Neomycin Affect Ribosomal Selectivity without Compromising Antibacterial Activity
ACS Infect. Dis., 2017, 3 (5), pp 368–377
DOI: 10.1021/acsinfecdis.6b00214

Exploring Covalent Allosteric Inhibition of Antigen 85C from Mycobacterium tuberculosis by Ebselen Derivatives
ACS Infect. Dis., 2017, 3 (5), pp 378–387
DOI: 10.1021/acsinfecdis.7b00003

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ACS Medicinal Chemistry Letters

INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology
Open access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2017, 8 (5), pp 486–491
DOI: 10.1021/acsmedchemlett.6b00391

Biocatalysis in the Pharmaceutical Industry: The Need for Speed
ACS Med. Chem. Lett., 2017, 8 (5), pp 476–480
DOI: 10.1021/acsmedchemlett.7b00114

Toward Resolving the Resveratrol Conundrum: Synthesis and in Vivo Pharmacokinetic Evaluation of BCP–Resveratrol
ACS Med. Chem. Lett., 2017, 8 (5), pp 516–520
DOI: 10.1021/acsmedchemlett.7b00018

Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma
ACS Med. Chem. Lett., 2017, 8 (5), pp 582–586
DOI: 10.1021/acsmedchemlett.7b00157

Development of Highly Affine and Selective Fluorinated Cannabinoid Type 2 Receptor Ligands
ACS Med. Chem. Lett., 2017, 8 (5), pp 566–571
DOI: 10.1021/acsmedchemlett.7b00129

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ACS Synthetic Biology

Application of an Acyl-CoA Ligase from Streptomyces aizunensis for Lactam Biosynthesis
Open access through ACS Editors’ Choice
ACS Synth. Biol., 2017, 6 (5), pp 884–890
DOI: 10.1021/acssynbio.6b00372

Meeting Report for Synthetic Biology for Natural Products 2017: The Interface of (Meta)Genomics, Machine Learning, and Natural Product Discovery
ACS Synth. Biol., 2017, 6 (5), pp 737–743
DOI: 10.1021/acssynbio.7b00132

Programmable DNA-Guided Artificial Restriction Enzymes
ACS Synth. Biol., 2017, 6 (5), pp 752–757
DOI: 10.1021/acssynbio.6b00324

Refactoring the Embden–Meyerhof–Parnas Pathway as a Whole of Portable GlucoBricks for Implantation of Glycolytic Modules in Gram-Negative Bacteria
Open access through ACS AuthorChoice
ACS Synth. Biol., 2017, 6 (5), pp 793–805
DOI: 10.1021/acssynbio.6b00230

Efficient Genome Editing of a Facultative Thermophile Using Mesophilic spCas9
Open access through ACS AuthorChoice
ACS Synth. Biol., 2017, 6 (5), pp 849–861
DOI: 10.1021/acssynbio.6b00339

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 Biochemistry

Neutron and Atomic Resolution X-ray Structures of a Lytic Polysaccharide Monooxygenase Reveal Copper-Mediated Dioxygen Binding and Evidence for N-Terminal Deprotonation
Biochemistry, 2017, 56 (20), pp 2529–2532
DOI: 10.1021/acs.biochem.7b00019

Using Ligand-Induced Protein Chemical Shift Perturbations To Determine Protein–Ligand Structures
Biochemistry, 2017, 56 (18), pp 2349–2362
DOI: 10.1021/acs.biochem.7b00170

Flexible DNA Path in the MCM Double Hexamer Loaded on DNA
Biochemistry, 2017, 56 (19), pp 2435–2445
DOI: 10.1021/acs.biochem.6b00922

Acyl Carrier Protein Cyanylation Delivers a Ketoacyl Synthase–Carrier Protein Cross-Link
Biochemistry, 2017, 56 (20), pp 2533–2536
DOI: 10.1021/acs.biochem.7b00219

Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex
Open access through ACS AuthorChoice
Biochemistry, 2017, 56 (18), pp 2379–2384
DOI: 10.1021/acs.biochem.7b00179

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Bioconjugate Chemistry

General Dialdehyde Click Chemistry for Amine Bioconjugation
Bioconjugate Chem., 2017, 28 (5), pp 1422–1433
DOI: 10.1021/acs.bioconjchem.7b00106

Synthesis of BODIPY-Peptide Conjugates for Fluorescence Labeling of EGFR Overexpressing Cells
Bioconjugate Chem., 2017, 28 (5), pp 1566–1579
DOI: 10.1021/acs.bioconjchem.7b00211

Dual Plug-and-Display Synthetic Assembly Using Orthogonal Reactive Proteins for Twin Antigen Immunization
Open access through ACS AuthorChoice
Bioconjugate Chem., 2017, 28 (5), pp 1544–1551
DOI: 10.1021/acs.bioconjchem.7b00174

Acyl Fluorides: Fast, Efficient, and Versatile Lysine-Based Protein Conjugation via Plug-and-Play Strategy
Bioconjugate Chem., 2017, 28 (5), pp 1452–1457
DOI: 10.1021/acs.bioconjchem.7b00141

Bioimaging with Macromolecular Probes Incorporating Multiple BODIPY Fluorophore
Bioconjugate Chem., 2017, 28 (5), pp 1519–1528
DOI: 10.1021/acs.bioconjchem.7b00166

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Biomacromolecules

Enhancing Tumor Penetration of Nanomedicines
Biomacromolecules, 2017, 18 (5), pp 1449–1459
DOI: 10.1021/acs.biomac.7b00068

Multifunctional Enzymatically Generated Hydrogels for Chronic Wound Application
Biomacromolecules, 2017, 18 (5), pp 1544–1555
DOI: 10.1021/acs.biomac.7b00111

Carborane Derivative Conjugated with Gold Nanoclusters for Targeted Cancer Cell Imaging
Biomacromolecules, 2017, 18 (5), pp 1466–1472
DOI: 10.1021/acs.biomac.6b01845

Engineered Polymer–Transferrin Conjugates as Self-Assembling Targeted Drug Delivery Systems
Biomacromolecules, 2017, 18 (5), pp 1532–1543
DOI: 10.1021/acs.biomac.7b00101

Evaluation of the Antimicrobial Activity of Cationic Polymers against Mycobacteria: Toward Antitubercular Macromolecules
Open access through ACS AuthorChoice
Biomacromolecules, 2017, 18 (5), pp 1592–1599
DOI: 10.1021/acs.biomac.7b00210

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Journal of Agricultural and Food Chemistry

Congratulations to the Best of 2016!
J. Agric. Food Chem., 2017, 65 (17), pp 3431–3431
DOI: 10.1021/acs.jafc.7b01734

Spectrophotometric Analysis of Phenolic Compounds in Grapes and Wines
J. Agric. Food Chem., 2017, 65 (20), pp 4009–4026
DOI: 10.1021/acs.jafc.7b01724

Sugar Beet Extract (Beta vulgaris L.) as a New Natural Emulsifier: Emulsion Formation
J. Agric. Food Chem., 2017, 65 (20), pp 4153–4160
DOI: 10.1021/acs.jafc.7b00441

Application of Deep Eutectic Solvents (DES) for Phenolic Compounds Extraction: Overview, Challenges, and Opportunities
J. Agric. Food Chem., 2017, 65 (18), pp 3591–3601
DOI: 10.1021/acs.jafc.7b01054

Surrogate Standards: A Cost-Effective Strategy for Identification of Phytochemicals
J. Agric. Food Chem., 2017, 65 (18), pp 3589–3590
DOI: 10.1021/acs.jafc.7b01588

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Journal of Chemical Theory and Computation

A Robust and Accurate Tight-Binding Quantum Chemical Method for Structures, Vibrational Frequencies, and Noncovalent Interactions of Large Molecular Systems Parametrized for All spd-Block Elements (Z = 1–86)
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2017, 13 (5), pp 1989–2009
DOI: 10.1021/acs.jctc.7b00118

Suppressing Ionic Terms with Number-Counting Jastrow Factors in Real Space
Open access through ACS Editors’ Choice
J. Chem. Theory Comput., 2017, 13 (5), pp 2035–2042
DOI: 10.1021/acs.jctc.7b00158

Assessing DFT-D3 Damping Functions Across Widely Used Density Functionals: Can We Do Better?
J. Chem. Theory Comput., 2017, 13 (5), pp 2043–2052
DOI: 10.1021/acs.jctc.7b00176

Comparison of QM/MM Methods To Obtain Ligand-Binding Free Energies
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2017, 13 (5), pp 2245–2253
DOI: 10.1021/acs.jctc.6b01217

Critical Comparison of Biomembrane Force Fields: Protein–Lipid Interactions at the Membrane Interface
J. Chem. Theory Comput., 2017, 13 (5), pp 2310–2321
DOI: 10.1021/acs.jctc.7b00001

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Journal of Medicinal Chemistry

Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis
Open access through ACS Editors’ Choice
J. Med. Chem., 2017, 60 (9), pp 3580–3590
DOI: 10.1021/acs.jmedchem.7b00032

Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors
J. Med. Chem., 2017, 60 (10), pp 4386–4402
DOI: 10.1021/acs.jmedchem.7b00359

Pentafluorosulfanyl-Substituted Benzopyran Analogues As New Cyclooxygenase-2 Inhibitors with Excellent Pharmacokinetics and Efficacy in Blocking Inflammation
J. Med. Chem., 2017, 60 (10), pp 4135–4146
DOI: 10.1021/acs.jmedchem.6b01484

Discovery of a B-Cell Lymphoma 6 Protein–Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach
J. Med. Chem., 2017, 60 (10), pp 4358–4368
DOI: 10.1021/acs.jmedchem.7b00313

7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis
J. Med. Chem., 2017, 60 (10), pp 4212–4233
DOI: 10.1021/acs.jmedchem.7b00034

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Journal of Natural Products

Total Synthesis of Tedarene A
J. Nat. Prod., 2017, 80 (5), pp 1623–1630
DOI: 10.1021/acs.jnatprod.7b00199

Structural Revision and Biosynthesis of the Fungal Phytotoxins Phyllostictines A and B
J. Nat. Prod., 2017, 80 (5), pp 1235–1240
DOI: 10.1021/acs.jnatprod.7b00183

Vitepyrroloids A–D, 2-Cyanopyrrole-Containing Labdane Diterpenoid Alkaloids from the Leaves of Vitex trifolia
J. Nat. Prod., 2017, 80 (5), pp 1679–1683
DOI: 10.1021/acs.jnatprod.6b01195

Antiplasmodial Sesquiterpenoid Lactones from Trichospira verticillata: Structure Elucidation by Spectroscopic Methods and Comparison of Experimental and Calculated ECD Data
J. Nat. Prod., 2017, 80 (5), pp 1639–1647
DOI: 10.1021/acs.jnatprod.7b00247

Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089
J. Nat. Prod., 2017, 80 (5), pp 1594–1603
DOI: 10.1021/acs.jnatprod.7b00176

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The Journal of Physical Chemistry B

What Does “Important New Physical Insights” Mean? Tips for Writing Better Papers
J. Phys. Chem. B, 2017, 121 (19), pp 4947–4948
DOI: 10.1021/acs.jpcb.7b04301

Predicting a Drug’s Membrane Permeability: A Computational Model Validated With in Vitro Permeability Assay Data
Open access through ACS AuthorChoice
J. Phys. Chem. B, 2017, 121 (20), pp 5228–5237
DOI: 10.1021/acs.jpcb.7b02914

Deficiencies in Molecular Dynamics Simulation-Based Prediction of Protein–DNA Binding Free Energy Landscapes
J. Phys. Chem. B, 2017, 121 (20), pp 5151–5161
DOI: 10.1021/acs.jpcb.6b12450

Hydrophobic Nanoparticles Modify the Thermal Release Behavior of Liposomes
J. Phys. Chem. B, 2017, 121 (19), pp 5040–5047
DOI: 10.1021/acs.jpcb.7b01702

Theory and Electrochemistry of Cytochrome c
J. Phys. Chem. B, 2017, 121 (19), pp 4958–4967
DOI: 10.1021/acs.jpcb.7b00917

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The Journal of Physical Chemistry Letters

Plasmon-Coupled Resonance Energy Transfer
J. Phys. Chem. Lett., 2017, 8 (10), pp 2357–2367
DOI: 10.1021/acs.jpclett.7b00526

Rashba Band Splitting in Organohalide Lead Perovskites: Bulk and Surface Effects
J. Phys. Chem. Lett., 2017, 8 (10), pp 2247–2252
DOI: 10.1021/acs.jpclett.7b00328

Size- and Wavelength-Dependent Two-Photon Absorption Cross-Section of CsPbBr3 Perovskite Quantum Dots
J. Phys. Chem. Lett., 2017, 8 (10), pp 2316–2321
DOI: 10.1021/acs.jpclett.7b00613

Importance of Solvation for the Accurate Prediction of Oxygen Reduction Activities of Pt-Based Electrocatalysts
J. Phys. Chem. Lett., 2017, 8 (10), pp 2243–2246
DOI: 10.1021/acs.jpclett.7b01018

Chemisorbed and Physisorbed Water at the TiO2/Water Interface
J. Phys. Chem. Lett., 2017, 8 (10), pp 2195–2199
DOI: 10.1021/acs.jpclett.7b00564

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Journal of Proteome Research

High-Throughput Analysis of Intact Human Proteins Using UVPD and HCD on an Orbitrap Mass Spectrometer
J. Proteome Res., 2017, 16 (5), pp 2072–2079
DOI: 10.1021/acs.jproteome.7b00043

Investigating Acquisition Performance on the Orbitrap Fusion When Using Tandem MS/MS/MS Scanning with Isobaric Tags
J. Proteome Res., 2017, 16 (5), pp 1839–1846
DOI: 10.1021/acs.jproteome.7b00091

Evaluating the Characteristics of Reporter Ion Signal Acquired in the Orbitrap Analyzer for Isobaric Mass Tag Proteome Quantification Experiments
J. Proteome Res., 2017, 16 (5), pp 1831–1838
DOI: 10.1021/acs.jproteome.7b00092

Intra- and Interskeletal Proteome Variations in Fresh and Buried Bones
J. Proteome Res., 2017, 16 (5), pp 2016–2029
DOI: 10.1021/acs.jproteome.6b01070

The Hybrid Search: A Mass Spectral Library Search Method for Discovery of Modifications in Proteomics
J. Proteome Res., 2017, 16 (5), pp 1924–1935
DOI: 10.1021/acs.jproteome.6b00988

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Molecular Pharmaceutics

Encapsulation of Ibuprofen in CD-MOF and Related Bioavailability Studies
Mol. Pharmaceutics, 2017, 14 (5), pp 1831–1839
DOI: 10.1021/acs.molpharmaceut.7b00168

Bioconjugate Therapeutics: Current Progress and Future Perspective
Mol. Pharmaceutics, 2017, 14 (5), pp 1321–1324
DOI: 10.1021/acs.molpharmaceut.7b00263

Lipid–Drug Conjugate for Enhancing Drug Delivery
Mol. Pharmaceutics, 2017, 14 (5), pp 1325–1338
DOI: 10.1021/acs.molpharmaceut.6b01027

Tracking Antibody Distribution with Near-Infrared Fluorescent Dyes: Impact of Dye Structure and Degree of Labeling on Plasma Clearance
Open access through ACS Editors’ Choice
Mol. Pharmaceutics, 2017, 14 (5), pp 1623–1633
DOI: 10.1021/acs.molpharmaceut.6b01091

Iron Oxide Nanoparticle Based Contrast Agents for Magnetic Resonance Imaging
Mol. Pharmaceutics, 2017, 14 (5), pp 1352–1364
DOI: 10.1021/acs.molpharmaceut.6b00839

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If you have comments or questions for the author of this post, please e-mail: Axial@acs.org.