Discover the Most-Read Biological Chemistry Articles of June 2017

What were chemists reading in June of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each biological chemistry ACS Publications journal in June 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great June 2017 Chemistry Research:

Analytical Chemistry | Applied Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Organic/Inorganic Chemistry | Physical Chemistry

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ACS Biomaterials Science & Engineering

Surface Analysis of Nanocomplexes by X-ray Photoelectron Spectroscopy (XPS)
Open access through ACS Editors’ Choice
ACS Biomater. Sci. Eng., 2017, 3 (6), pp 882–889
DOI: 10.1021/acsbiomaterials.7b00040

3D-Printed High Strength Bioactive Supramolecular Polymer/Clay Nanocomposite Hydrogel Scaffold for Bone Regeneration
ACS Biomater. Sci. Eng., 2017, 3 (6), pp 1109–1118
DOI: 10.1021/acsbiomaterials.7b00224

Protein Corona around Gold Nanorods as a Drug Carrier for Multimodal Cancer Therapy
ACS Biomater. Sci. Eng., 2017, 3 (6), pp 1039–1050
DOI: 10.1021/acsbiomaterials.7b00231

Intestine-on-a-Chip Microfluidic Model for Efficient in Vitro Screening of Oral Chemotherapeutic Uptake
ACS Biomater. Sci. Eng., 2017, 3 (6), pp 951–959
DOI: 10.1021/acsbiomaterials.7b00023

Inkjet Printing-Based Patchable Multilayered Biomolecule-Containing Nanofilms for Biomedical Applications
ACS Biomater. Sci. Eng., 2017, 3 (6), pp 870–874
DOI: 10.1021/acsbiomaterials.7b00138

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ACS Catalysis

Visible Light-Mediated Direct Decarboxylative C–H Functionalization of Heteroarenes
ACS Catal., 2017, 7 (6), pp 4057–4061
DOI: 10.1021/acscatal.7b01133

Nest-like NiCoP for Highly Efficient Overall Water Splitting
ACS Catal., 2017, 7 (6), pp 4131–4137
DOI: 10.1021/acscatal.7b00662

Ultrathin Nitrogen-Doped Carbon Coated with CoP for Efficient Hydrogen Evolution
ACS Catal., 2017, 7 (6), pp 3824–3831
DOI: 10.1021/acscatal.7b00587

Nickel-Catalyzed C(sp2)–H/C(sp3)–H Oxidative Coupling of Indoles with Toluene Derivatives
ACS Catal., 2017, 7 (6), pp 4202–4208
DOI: 10.1021/acscatal.7b01044

Yin and Yang Dual Characters of CuOx Clusters for C–C Bond Oxidation Driven by Visible Light
Open access through ACS Editors’ Choice
ACS Catal., 2017, 7 (6), pp 3850–3859
DOI: 10.1021/acscatal.7b00629

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ACS Chemical Biology

NHS-Esters As Versatile Reactivity-Based Probes for Mapping Proteome-Wide Ligandable Hotspots
ACS Chem. Biol., 2017, 12 (6), pp 1478–1483
DOI: 10.1021/acschembio.7b00125

A Chemical-Genetic Approach to Generate Selective Covalent Inhibitors of Protein Kinases
ACS Chem. Biol., 2017, 12 (6), pp 1499–1503
DOI: 10.1021/acschembio.6b01083

Profiling Cellular Substrates of Lysine Acetyltransferases GCN5 and p300 with Orthogonal Labeling and Click Chemistry
ACS Chem. Biol., 2017, 12 (6), pp 1547–1555
DOI: 10.1021/acschembio.7b00114

A Macrocyclic Peptide Ligand Binds the Oncogenic MicroRNA-21 Precursor and Suppresses Dicer Processing
ACS Chem. Biol., 2017, 12 (6), pp 1611–1620
DOI: 10.1021/acschembio.7b00180

The Root Growth-Regulating Brevicompanine Natural Products Modulate the Plant Circadian Clock
Open access through ACS Editors’ Choice
ACS Chem. Biol., 2017, 12 (6), pp 1466–1471
DOI: 10.1021/acschembio.6b00978

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ACS Chemical Neuroscience

Classics in Chemical Neuroscience: Ketamine
ACS Chem. Neurosci., 2017, 8 (6), pp 1122–1134
DOI: 10.1021/acschemneuro.7b00074

Differentiating Physicochemical Properties between Addictive and Nonaddictive ADHD Drugs Revealed by Molecular Dynamics Simulation Studies
ACS Chem. Neurosci., 2017, 8 (6), pp 1416–1428
DOI: 10.1021/acschemneuro.7b00173

Reflections on 2016 and Projecting Forward
ACS Chem. Neurosci., 2017, 8 (6), pp 1117–1117
DOI: 10.1021/acschemneuro.7b00146

Emerging Insights for Better Delivery of Chemicals and Stem Cells to the Brain
ACS Chem. Neurosci., 2017, 8 (6), pp 1119–1121
DOI: 10.1021/acschemneuro.7b00106

Classics in Chemical Neuroscience: Aripiprazole
ACS Chem. Neurosci., 2017, 8 (6), pp 1135–1146
DOI: 10.1021/acschemneuro.7b00087

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ACS Infectious Diseases

Discovery of a Novel Nitric Oxide Binding Protein and Nitric-Oxide-Responsive Signaling Pathway in Pseudomonas aeruginosa
Open access through ACS Editors’ Choice
ACS Infect. Dis., 2017, 3 (6), pp 454–461
DOI: 10.1021/acsinfecdis.7b00027

A Phenotypic Based Target Screening Approach Delivers New Antitubercular CTP Synthetase Inhibitors
ACS Infect. Dis., 2017, 3 (6), pp 428–437
DOI: 10.1021/acsinfecdis.7b00006

Truncated Autoinducing Peptide Conjugates Selectively Recognize and Kill Staphylococcus aureus
ACS Infect. Dis., 2017, 3 (6), pp 406–410
DOI: 10.1021/acsinfecdis.7b00013

Diamide Inhibitors of the Bacillus subtilis N-Acetylglucosaminidase LytG That Exhibit Antibacterial Activity
ACS Infect. Dis., 2017, 3 (6), pp 421–427
DOI: 10.1021/acsinfecdis.7b00005

Cell Cycle-Dependent Kinase Cdk9 Is a Postexposure Drug Target against Human Adenoviruses
ACS Infect. Dis., 2017, 3 (6), pp 398–405
DOI: 10.1021/acsinfecdis.7b00009

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ACS Medicinal Chemistry Letters

Practical High-Throughput Experimentation for Chemists
Open access through ACS AuthorChoice
ACS Med. Chem. Lett., 2017, 8 (6), pp 601–607
DOI: 10.1021/acsmedchemlett.7b00165

Where Are Drugs Invented, and Why Does It Matter?
ACS Med. Chem. Lett., 2017, 8 (6), pp 589–591
DOI: 10.1021/acsmedchemlett.7b00185

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton’s Tyrosine Kinase with Improved Druglike Properties
Open access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2017, 8 (6), pp 608–613
DOI: 10.1021/acsmedchemlett.7b00103

Janus-Associated Kinase 1 (JAK1) Inhibitors as Potential Treatment for Immune Disorders
ACS Med. Chem. Lett., 2017, 8 (6), pp 598–600
DOI: 10.1021/acsmedchemlett.7b00209

Inhibitors of DNA Gyrase-GyrB Subunit and/or Topoisomerase IV-ParE Subunit May Treat Infectious Diseases Caused by Antibiotic-Resistant Bacteria
ACS Med. Chem. Lett., 2017, 8 (6), pp 592–594
DOI: 10.1021/acsmedchemlett.7b00207

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ACS Synthetic Biology

Extracellular Self-Assembly of Functional and Tunable Protein Conjugates from Bacillus subtilis
Open access through ACS AuthorChoice
ACS Synth. Biol., 2017, 6 (6), pp 957–967
DOI: 10.1021/acssynbio.6b00292

Quantitative Analysis of Synthetic Cell Lineage Tracing Using Nuclease Barcoding
ACS Synth. Biol., 2017, 6 (6), pp 936–942
DOI: 10.1021/acssynbio.6b00309

Inducible Control of mRNA Transport Using Reprogrammable RNA-Binding Proteins
Open access through ACS AuthorChoice
ACS Synth. Biol., 2017, 6 (6), pp 950–956
DOI: 10.1021/acssynbio.7b00025

Introducing Our Authors
ACS Synth. Biol., 2017, 6 (6), pp 915–920
DOI: 10.1021/acssynbio.7b00181

The Impact of DNA Topology and Guide Length on Target Selection by a Cytosine-Specific Cas9
ACS Synth. Biol., 2017, 6 (6), pp 1103–1113
DOI: 10.1021/acssynbio.7b00050

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Biochemistry

Conformational Heterogeneity and DNA Recognition by the Morphogen Bicoid
Open access through ACS Editors’ Choice
Biochemistry, 2017, 56 (22), pp 2787–2793
DOI: 10.1021/acs.biochem.7b00255

Yes, Biochemistry Now Publishes Communications and Something New—From the Bench
Biochemistry, 2017, 56 (23), pp 2863–2864
DOI: 10.1021/acs.biochem.7b00474

Metamorphic Proteins: Emergence of Dual Protein Folds from One Primary Sequence
Biochemistry, 2017, 56 (24), pp 2971–2984
DOI: 10.1021/acs.biochem.7b00375

Expanding the Scope of Electrophiles Capable of Targeting K-Ras Oncogenes
Biochemistry, 2017, 56 (25), pp 3178–3183
DOI: 10.1021/acs.biochem.7b00271

Structure–Energy Relationships of Halogen Bonds in Proteins
Open access through ACS Editors’ Choice
Biochemistry, 2017, 56 (22), pp 2794–2802
DOI: 10.1021/acs.biochem.7b00022

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Bioconjugate Chemistry

Gold Nanoparticle Size and Shape Effects on Cellular Uptake and Intracellular Distribution of siRNA Nanoconstructs
Bioconjugate Chem., 2017, 28 (6), pp 1791–1800
DOI: 10.1021/acs.bioconjchem.7b00252

Ruthenium Promoted On-DNA Ring-Closing Metathesis and Cross-Metathesis
Bioconjugate Chem., 2017, 28 (6), pp 1625–1629
DOI: 10.1021/acs.bioconjchem.7b00292

Bioorthogonal Protein Conjugation: Application to the Development of a Highly Sensitive Bioluminescent Immunoassay for the Detection of Interferon-γ
Bioconjugate Chem., 2017, 28 (6), pp 1749–1757
DOI: 10.1021/acs.bioconjchem.7b00220

Tunable Semiconducting Polymer Nanoparticles with INDT-Based Conjugated Polymers for Photoacoustic Molecular Imaging
Open access through ACS AuthorChoice
Bioconjugate Chem., 2017, 28 (6), pp 1734–1740
DOI: 10.1021/acs.bioconjchem.7b00185

Europium-Labeled Synthetic C3a Protein as a Novel Fluorescent Probe for Human Complement C3a Receptor
Bioconjugate Chem., 2017, 28 (6), pp 1669–1676
DOI: 10.1021/acs.bioconjchem.7b00132

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Biomacromolecules

Polymer Brush-Functionalized Chitosan Hydrogels as Antifouling Implant Coatings
Open access through ACS AuthorChoice
Biomacromolecules, 2017, 18 (6), pp 1983–1992
DOI: 10.1021/acs.biomac.7b00516

Synthesis and Characterization of Micelle-Forming PEG-Poly(Amino Acid) Copolymers with Iron-Hydroxamate Cross-Linkable Blocks for Encapsulation and Release of Hydrophobic Drugs
Open access through ACS AuthorChoice
Biomacromolecules, 2017, 18 (6), pp 1874–1884
DOI: 10.1021/acs.biomac.7b00317

Alginate Beads Containing Lactase: Stability and Microstructure
Biomacromolecules, 2017, 18 (6), pp 1785–1792
DOI: 10.1021/acs.biomac.7b00202

Hyaluronan-Inorganic Nanohybrid Materials for Biomedical Applications
Biomacromolecules, 2017, 18 (6), pp 1677–1696
DOI: 10.1021/acs.biomac.7b00424

Correction to Multifunctional Enzymatically Generated Hydrogels for Chronic Wound Application
Biomacromolecules, 2017, 18 (6), pp 2012–2012
DOI: 10.1021/acs.biomac.7b00681

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Journal of Agricultural and Food Chemistry

Control of Maillard Reactions in Foods: Strategies and Chemical Mechanisms
Open access through ACS AuthorChoice
J. Agric. Food Chem., 2017, 65 (23), pp 4537–4552
DOI: 10.1021/acs.jafc.7b00882

Novel trans-Ferulic Acid Derivatives Containing a Chalcone Moiety as Potential Activator for Plant Resistance Induction
Open access through ACS Editors’ Choice
J. Agric. Food Chem., 2017, 65 (22), pp 4367–4377
DOI: 10.1021/acs.jafc.7b00958

Characterization of Aroma-Active Compounds in Italian Tomatoes with Emphasis on New Odorants
J. Agric. Food Chem., 2017, 65 (25), pp 5198–5208
DOI: 10.1021/acs.jafc.7b01108

Higher Antioxidant Activity, Total Flavonols, and Specific Quercetin Glucosides in Two Different Onion (Allium cepa L.) Varieties Grown under Organic Production: Results from a 6-Year Field Study
J. Agric. Food Chem., 2017, 65 (25), pp 5122–5132
DOI: 10.1021/acs.jafc.7b01352

Pesticide Interactions: Mechanisms, Benefits, and Risks
J. Agric. Food Chem., 2017, 65 (23), pp 4553–4561
DOI: 10.1021/acs.jafc.7b01813

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Journal of Chemical Theory and Computation

Real Cost of Speed: The Effect of a Time-Saving Multiple-Time-Stepping Algorithm on the Accuracy of Molecular Dynamics Simulations
J. Chem. Theory Comput., 2017, 13 (6), pp 2367–2372
DOI: 10.1021/acs.jctc.7b00178

Revisiting Hydrogen Bond Thermodynamics in Molecular Simulations
J. Chem. Theory Comput., 2017, 13 (6), pp 2851–2857
DOI: 10.1021/acs.jctc.7b00238

Neural Network and Nearest Neighbor Algorithms for Enhancing Sampling of Molecular Dynamics
J. Chem. Theory Comput., 2017, 13 (6), pp 2489–2500
DOI: 10.1021/acs.jctc.7b00188

The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design
J. Chem. Theory Comput., 2017, 13 (6), pp 3031–3048
DOI: 10.1021/acs.jctc.7b00125

Local Descriptors of Dynamic and Nondynamic Correlation
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2017, 13 (6), pp 2705–2711
DOI: 10.1021/acs.jctc.7b00293

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Journal of Medicinal Chemistry

Multitargeted Imidazoles: Potential Therapeutic Leads for Alzheimer’s and Other Neurodegenerative Diseases
Open access through ACS AuthorChoice
J. Med. Chem., 2017, 60 (12), pp 5120–5145
DOI: 10.1021/acs.jmedchem.7b00475

Design and Discovery of N-(2-Methyl-5′-morpholino-6′-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers
J. Med. Chem., 2017, 60 (12), pp 4869–4881
DOI: 10.1021/acs.jmedchem.6b01862

Drug Annotation
J. Med. Chem., 2017, 60 (11), pp 4559–4572
DOI: 10.1021/acs.jmedchem.7b00408

Hot-Spotting with Thermal Scanning: A Ligand- and Structure-Independent Assessment of Target Ligandability
J. Med. Chem., 2017, 60 (12), pp 4923–4931
DOI: 10.1021/acs.jmedchem.7b00208

Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes
Open access through ACS AuthorChoice
J. Med. Chem., 2017, 60 (12), pp 5209–5215
DOI: 10.1021/acs.jmedchem.6b01224

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Journal of Natural Products

Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity
J. Nat. Prod., 2017, 80 (6), pp 1767–1775
DOI: 10.1021/acs.jnatprod.6b01099

The First Enantioselective Total Synthesis of (−)-trans-Dihydronarciclasine
J. Nat. Prod., 2017, 80 (6), pp 1909–1917
DOI: 10.1021/acs.jnatprod.7b00208

Potent Inhibitor of Drug-Resistant HIV-1 Strains Identified from the Medicinal Plant Justicia gendarussa
J. Nat. Prod., 2017, 80 (6), pp 1798–1807
DOI: 10.1021/acs.jnatprod.7b00004

Biosynthesis of Fluorinated Peptaibols Using a Site-Directed Building Block Incorporation Approach
Open access through ACS AuthorChoice
J. Nat. Prod., 2017, 80 (6), pp 1883–1892
DOI: 10.1021/acs.jnatprod.7b00189

Anti-inflammatory 12,20-Epoxypregnane and 11,12-seco-Pregnane Glycosides from the Stems of Hoya kerrii
J. Nat. Prod., 2017, 80 (6), pp 1714–1724
DOI: 10.1021/acs.jnatprod.6b00730

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The Journal of Physical Chemistry B

Virtual Issue in Memory of David Chandler
J. Phys. Chem. B, 2017, 121 (21), pp 5309–5311
DOI: 10.1021/acs.jpcb.7b04830

Fluorescence Dynamics of a FRET Probe Designed for Crowding Studies
J. Phys. Chem. B, 2017, 121 (23), pp 5688–5698
DOI: 10.1021/acs.jpcb.7b01306

Second-Generation ReaxFF Water Force Field: Improvements in the Description of Water Density and OH-Anion Diffusion
J. Phys. Chem. B, 2017, 121 (24), pp 6021–6032
DOI: 10.1021/acs.jpcb.7b02548
Reunderstanding the Fluorescent Behavior of Four-Coordinate Monoboron Complexes Containing Monoanionic Bidentate Ligands
J. Phys. Chem. B, 2017, 121 (25), pp 6189–6199
DOI: 10.1021/acs.jpcb.7b02405
Enhanced Sampling of Phase Transitions in Coarse-Grained Lipid Bilayers
J. Phys. Chem. B, 2017, 121 (23), pp 5770–5780
DOI: 10.1021/acs.jpcb.6b11711

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The Journal of Physical Chemistry Letters

Novel Liposome-Based Surface-Enhanced Raman Spectroscopy (SERS) Substrate
Open access through ACS Editors’ Choice
J. Phys. Chem. Lett., 2017, 8 (12), pp 2639–2646
DOI: 10.1021/acs.jpclett.7b00694

Intrinsic Bond Energies from a Bonds-in-Molecules Neural Network
J. Phys. Chem. Lett., 2017, 8 (12), pp 2689–2694
DOI: 10.1021/acs.jpclett.7b01072

Are Electron Affinity and Ionization Potential Intrinsic Parameters to Predict the Electron or Hole Acceptor Character of Amorphous Molecular Materials?
J. Phys. Chem. Lett., 2017, 8 (11), pp 2445–2449
DOI: 10.1021/acs.jpclett.7b00681

Reversible Concentration-Dependent Photoluminescence Quenching and Change of Emission Color in CsPbBr3 Nanowires and Nanoplatelets
J. Phys. Chem. Lett., 2017, 8 (12), pp 2725–2729
DOI: 10.1021/acs.jpclett.7b01305

Pressure-Induced Effects in Organic–Inorganic Hybrid Perovskites
J. Phys. Chem. Lett., 2017, 8 (12), pp 2613–2622
DOI: 10.1021/acs.jpclett.7b00347

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Journal of Proteome Research

Differential Protein Analysis of IPEC-J2 Cells Infected with Porcine Epidemic Diarrhea Virus Pandemic and Classical Strains Elucidates the Pathogenesis of Infection
J. Proteome Res., 2017, 16 (6), pp 2113–2120
DOI: 10.1021/acs.jproteome.6b00957

iTRAQ and RNA-Seq Analyses Provide New Insights into Regulation Mechanism of Symbiotic Germination of Dendrobium officinale Seeds (Orchidaceae)
J. Proteome Res., 2017, 16 (6), pp 2174–2187
DOI: 10.1021/acs.jproteome.6b00999

Metabolomics–Proteomics Combined Approach Identifies Differential Metabolism-Associated Molecular Events between Senescence and Apoptosis
J. Proteome Res., 2017, 16 (6), pp 2250–2261
DOI: 10.1021/acs.jproteome.7b00111

Metabolomics Study of the Effects of Inflammation, Hypoxia, and High Glucose on Isolated Human Pancreatic Islets
J. Proteome Res., 2017, 16 (6), pp 2294–2306
DOI: 10.1021/acs.jproteome.7b00160

Unbiased Protein Association Study on the Public Human Proteome Reveals Biological Connections between Co-Occurring Protein Pairs
Open access through ACS AuthorChoice
J. Proteome Res., 2017, 16 (6), pp 2204–2212
DOI: 10.1021/acs.jproteome.6b01066

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Molecular Pharmaceutics

Functionalized Lipid–Polymer Hybrid Nanoparticles Mediated Codelivery of Methotrexate and Aceclofenac: A Synergistic Effect in Breast Cancer with Improved Pharmacokinetics Attributes
Mol. Pharmaceutics, 2017, 14 (6), pp 1883–1897
DOI: 10.1021/acs.molpharmaceut.6b01148

Development of a Biorelevant, Material-Sparing Membrane Flux Test for Rapid Screening of Bioavailability-Enhancing Drug Product Formulations
Mol. Pharmaceutics, 2017, 14 (6), pp 2032–2046
DOI: 10.1021/acs.molpharmaceut.7b00121

Acid-Sensitive Sheddable PEGylated, Mannose-Modified Nanoparticles Increase the Delivery of Betamethasone to Chronic Inflammation Sites in a Mouse Model
Mol. Pharmaceutics, 2017, 14 (6), pp 1929–1937
DOI: 10.1021/acs.molpharmaceut.7b00024

Superior Plasticity and Tabletability of Theophylline Monohydrate
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2017, 14 (6), pp 2047–2055
DOI: 10.1021/acs.molpharmaceut.7b00124

Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations
Mol. Pharmaceutics, 2017, 14 (6), pp 1852–1860
DOI: 10.1021/acs.molpharmaceut.6b01015

 

 

 

 

 

 

 

 

 

 

 

 

 

If you have comments or questions for the author of this post, please e-mail: Axial@acs.org.