Discover the Most-Read Organic/Inorganic Chemistry Articles of July 2017

What were chemists reading in July of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each organic or inorganic chemistry ACS Publications journal in July 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great July 2017 Chemistry Research:
Analytical Chemistry | Applied Chemistry | Biological Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Physical Chemistry

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ACS Catalysis

Ceria Catalysts at Nanoscale: How Do Crystal Shapes Shape Catalysis?
ACS Catal., 2017, 7 (7), pp 4716–4735
DOI: 10.1021/acscatal.7b01246

Kinetic Modeling of the Nickel-Catalyzed Esterification of Amides
Open access through ACS Editors’ Choice
ACS Catal., 2017, 7 (7), pp 4381–4385
DOI: 10.1021/acscatal.7b01444

Engaging Radicals in Transition Metal-Catalyzed Cross-Coupling with Alkyl
ACS Catal., 2017, 7 (7), pp 4697–4706
DOI: 10.1021/acscatal.7b01405

Global Scholarly Publishing and the Impact of Catalysis
ACS Catal., 2017, 7 (7), pp 4621–4622
DOI: 10.1021/acscatal.7b01764

Understanding Selectivity for the Electrochemical Reduction of Carbon Dioxide to Formic Acid and Carbon Monoxide on Metal Electrodes
ACS Catal., 2017, 7 (7), pp 4822–4827
DOI: 10.1021/acscatal.7b00687

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ACS Combinatorial Science

“On-Water” Facile Synthesis of Novel Pyrazolo[3,4-b]pyridinones Possessing Anti-influenza Virus Activity
ACS Comb. Sci., 2017, 19 (7), pp 437–446
DOI: 10.1021/acscombsci.7b00016

“In Water”: Organocatalyzed Diastereoselective Multicomponent Reactions toward 2-Azapyrrolizidine Alkaloid Scaffolds
ACS Comb. Sci., 2017, 19 (7), pp 455–463
DOI: 10.1021/acscombsci.7b00038

High-Throughput Platform for Synthesis of Melamine-Formaldehyde Microcapsules
ACS Comb. Sci., 2017, 19 (7), pp 447–454
DOI: 10.1021/acscombsci.7b00037

Synthesis and Screening of Phase Change Chalcogenide Thin Film Materials for Data Storage
ACS Comb. Sci., 2017, 19 (7), pp 478–491
DOI: 10.1021/acscombsci.7b00047

Synthesis of Aminofuran-Linked Benzimidazoles and Cyanopyrrole-Fused Benzimidazoles by Condition-Based Skeletal Divergence
ACS Comb. Sci., 2017, 19 (7), pp 492–499
DOI: 10.1021/acscombsci.7b00052

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ACS Medicinal Chemistry Letters

Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor
ACS Med. Chem. Lett., 2017, 8 (7), pp 771–774
DOI: 10.1021/acsmedchemlett.7b00211

Taking Pharmaceutical Innovation to the Masses
ACS Med. Chem. Lett., 2017, 8 (7), pp 686–689
DOI: 10.1021/acsmedchemlett.7b00173

Seeking (and Finding) Biased Ligands of the Kappa Opioid Receptor
ACS Med. Chem. Lett., 2017, 8 (7), pp 694–700
DOI: 10.1021/acsmedchemlett.7b00224

Synthesis and Biological Evaluation of Paclitaxel and Camptothecin Prodrugs on the Basis of 2-Nitroimidazole
ACS Med. Chem. Lett., 2017, 8 (7), pp 762–765
DOI: 10.1021/acsmedchemlett.7b00189

Biosimilars: Imitation Games
ACS Med. Chem. Lett., 2017, 8 (7), pp 690–693
DOI: 10.1021/acsmedchemlett.7b00199

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Bioconjugate Chemistry

Protease-Cleavable Linkers Modulate the Anticancer Activity of Noninternalizing Antibody–Drug Conjugates
Bioconjugate Chem., 2017, 28 (7), pp 1826–1833
DOI: 10.1021/acs.bioconjchem.7b00304

Enhanced and Prolonged Cell-Penetrating Abilities of Arginine-Rich Peptides by Introducing Cyclic α,α-Disubstituted α-Amino Acids with Stapling
Bioconjugate Chem., 2017, 28 (7), pp 1801–1806
DOI: 10.1021/acs.bioconjchem.7b00190

Targeting CpG Adjuvant to Lymph Node via Dextran Conjugate Enhances Antitumor Immunotherapy
Bioconjugate Chem., 2017, 28 (7), pp 1993–2000
DOI: 10.1021/acs.bioconjchem.7b00313

Fabrication of Polymeric Micelles with Aggregation-Induced Emission and Forster Resonance Energy Transfer for Anticancer Drug Delivery
Bioconjugate Chem., 2017, 28 (7), pp 1944–1954
DOI: 10.1021/acs.bioconjchem.7b00274

Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]–Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization
Bioconjugate Chem., 2017, 28 (7), pp 1916–1924
DOI: 10.1021/acs.bioconjchem.7b00242

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Inorganic Chemistry

Mercouri G. Kanatzidis: Excellence and Innovations in Inorganic and Solid-State Chemistry
Inorg. Chem., 2017, 56 (14), pp 7582–7597
DOI: 10.1021/acs.inorgchem.7b00933

Metal–Metal Bonds: From Fundamentals to Applications
Inorg. Chem., 2017, 56 (14), pp 7577–7581
DOI: 10.1021/acs.inorgchem.7b01330

A Highly Selective and Robust Co(II)-Based Homogeneous Catalyst for Reduction of CO2 to CO in CH3CN/H2O Solution Driven by Visible Light
Inorg. Chem., 2017, 56 (13), pp 7307–7311
DOI: 10.1021/acs.inorgchem.7b00566

Second-Coordination-Sphere Assisted Selective Colorimetric Turn-on Fluoride Sensing by a Mono-Metallic Co(II) Hexacarboxamide Cryptand Complex
Inorg. Chem., 2017, 56 (14), pp 7615–7619
DOI: 10.1021/acs.inorgchem.7b01335

A Flexible Fluorescent Zr Carboxylate Metal–Organic Framework for the Detection of Electron-Rich Molecules in Solution
Inorg. Chem., 2017, 56 (14), pp 8423–8429
DOI: 10.1021/acs.inorgchem.7b01103

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Journal of Medicinal Chemistry

The Fragment Network: A Chemistry Recommendation Engine Built Using a Graph Database
Open Access Through ACS Editor’s Choice
J. Med. Chem., 2017, 60 (14), pp 6440–6450
DOI: 10.1021/acs.jmedchem.7b00809

Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1
J. Med. Chem., 2017, 60 (13), pp 5857–5867
DOI: 10.1021/acs.jmedchem.7b00293

Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer
J. Med. Chem., 2017, 60 (14), pp 6018–6035
DOI: 10.1021/acs.jmedchem.7b00076

Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo
J. Med. Chem., 2017, 60 (13), pp 5717–5735
DOI: 10.1021/acs.jmedchem.7b00425

Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B
J. Med. Chem., 2017, 60 (14), pp 6137–6151
DOI: 10.1021/acs.jmedchem.7b00365

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Journal of Natural Products

Gaditanone, a Diterpenoid Based on an Unprecedented Carbon Skeleton Isolated from Euphorbia gaditana
J. Nat. Prod., 2017, 80 (7), pp 2161–2165
DOI: 10.1021/acs.jnatprod.7b00332

Spirograterpene A, a Tetracyclic Spiro-Diterpene with a Fused 5/5/5/5 Ring System from the Deep-Sea-Derived Fungus Penicillium granulatum MCCC 3A00475
J. Nat. Prod., 2017, 80 (7), pp 2174–2177
DOI: 10.1021/acs.jnatprod.7b00475

Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking
J. Nat. Prod., 2017, 80 (7), pp 2051–2059
DOI: 10.1021/acs.jnatprod.7b00233

Mushroom-Derived Indole Alkaloids
J. Nat. Prod., 2017, 80 (7), pp 2178–2187
DOI: 10.1021/acs.jnatprod.7b00390

Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis
Open access through ACS AuthorChoice
J. Nat. Prod., 2017, 80 (7), pp 2060–2066
DOI: 10.1021/acs.jnatprod.7b00255

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 The Journal of Organic Chemistry

Transition Metal-Free α-Csp3-H Methylenation of Ketones to Form C═C Bond Using Dimethyl Sulfoxide as Carbon Source
J. Org. Chem., 2017, 82 (14), pp 7159–7164
DOI: 10.1021/acs.joc.7b00619

Coupling of Challenging Heteroaryl Halides with Alkyl Halides via Nickel-Catalyzed Cross-Electrophile Coupling
J. Org. Chem., 2017, 82 (14), pp 7085–7092
DOI: 10.1021/acs.joc.7b01334

NIS Mediated Cross-Coupling of C(sp2)–H and N–H Bonds: A Transition-Metal-Free Approach toward Indolo[1,2-a]quinazolinones
J. Org. Chem., 2017, 82 (14), pp 7657–7665
DOI: 10.1021/acs.joc.7b01080

Transition-Metal-Free and Oxidant-Free Cross-Coupling of Arylhydrazines with Disulfides: Base-Promoted Synthesis of Unsymmetrical Aryl Sulfides
J. Org. Chem., 2017, 82 (13), pp 6647–6655
DOI: 10.1021/acs.joc.7b00767

 Pyrene-Based Approach to Tune Emission Color from Blue to Yellow
J. Org. Chem., 2017, 82 (14), pp 7176–7182
DOI: 10.1021/acs.joc.7b00685

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Molecular Pharmaceutics

Clinically Relevant Multidrug Transporters Are Regulated by microRNAs along the Human Intestine
Open access through ACS Editors’ Choice
Mol. Pharmaceutics, 2017, 14 (7), pp 2245–2253
DOI: 10.1021/acs.molpharmaceut.7b00076

Impact of Drug-Rich Colloids of Itraconazole and HPMCAS on Membrane Flux in Vitro and Oral Bioavailability in Rats
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2017, 14 (7), pp 2437–2449
DOI: 10.1021/acs.molpharmaceut.7b00338

Chitosan/Hyaluronic Acid Nanoparticles: Rational Design Revisited for RNA Delivery
Mol. Pharmaceutics, 2017, 14 (7), pp 2422–2436
DOI: 10.1021/acs.molpharmaceut.7b00320

Targeting the Central Nervous System (CNS): A Review of Rabies Virus-Targeting Strategies
Mol. Pharmaceutics, 2017, 14 (7), pp 2177–2196
DOI: 10.1021/acs.molpharmaceut.7b00158

In Vivo Pretargeted Imaging of HER2 and TAG-72 Expression Using the HaloTag Enzyme
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2017, 14 (7), pp 2307–2313
DOI: 10.1021/acs.molpharmaceut.7b00172

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Organic Letters

Dehydrative Cp*Co(III)-Catalyzed C–H Bond Allenylation
Org. Lett., 2017, 19 (14), pp 3699–3702
DOI: 10.1021/acs.orglett.7b01415

Phosphorylation of Alkenyl and Aryl C–O Bonds via Photoredox/Nickel Dual Catalysis
Org. Lett., 2017, 19 (14), pp 3735–3738
DOI: 10.1021/acs.orglett.7b01561

Aminomethylation of Imidazoheterocycles with Morpholine
Org. Lett., 2017, 19 (14), pp 3751–3754
DOI: 10.1021/acs.orglett.7b01594

Electrochemical Nickel Catalysis for Sp2-Sp3 Cross-Electrophile Coupling Reactions of Unactivated Alkyl Halides
Org. Lett., 2017, 19 (14), pp 3755–3758
DOI: 10.1021/acs.orglett.7b01598

Photocatalytic α-Acylation of Ethers
Org. Lett., 2017, 19 (14), pp 3727–3730
DOI: 10.1021/acs.orglett.7b01552

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Organic Process Research & Development

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2017, 21 (7), pp 897–910
DOI: 10.1021/acs.oprd.7b00219

Risk Considerations on Developing a Continuous Crystallization System for Carbamazepine
Open access through ACS Editors’ Choice
Org. Process Res. Dev., 2017, 21 (7), pp 1021–1033
DOI: 10.1021/acs.oprd.7b00130

Continuous Photo-Oxidation in a Vortex Reactor: Efficient Operations Using Air Drawn from the Laboratory
Open access through ACS AuthorChoice
Org. Process Res. Dev., 2017, 21 (7), pp 1042–1050
DOI: 10.1021/acs.oprd.7b00153

Screwing NaBH4 through a Barrel without a Bang: A Kneaded Alternative to Fed-Batch Carbonyl Reductions
Org. Process Res. Dev., 2017, 21 (7), pp 992–1002
DOI: 10.1021/acs.oprd.7b00107

Cp2TiCl: An Ideal Reagent for Green Chemistry?
Org. Process Res. Dev., 2017, 21 (7), pp 911–923
DOI: 10.1021/acs.oprd.7b00098

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Organometallics

Bis(boryl anion)-Substituted Pyrenes: Syntheses, Characterizations, and Crystal Structures
Organometallics, 2017, 36 (14), pp 2498–2501
DOI: 10.1021/acs.organomet.7b00368

Bistable Polyaromatic Aminoboranes: Bright Solid State Emission and Mechanochromism
Organometallics, 2017, 36 (14), pp 2692–2701
DOI: 10.1021/acs.organomet.7b00332

BArF3-Catalyzed Imine Hydroboration with Pinacolborane Not Requiring the Assistance of an Additional Lewis Base
Organometallics, 2017, 36 (13), pp 2381–2384
DOI: 10.1021/acs.organomet.7b00381

Palladium-Catalyzed Remote meta-Selective C–H Bond Silylation and Germanylation
Organometallics, 2017, 36 (13), pp 2418–2423
DOI: 10.1021/acs.organomet.7b00309

Improved Synthetic Route to Heteroleptic Alkylphosphine Oxides
Organometallics, 2017, 36 (13), pp 2412–2417
DOI: 10.1021/acs.organomet.7b00304

If you have comments or questions for the author of this post, please e-mail: Axial@acs.org.