Discover the Most-Read Biological Chemistry Articles of September 2017

What were chemists reading in September of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each biological chemistry ACS Publications journal in September 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great September 2017 Chemistry Research:

Analytical Chemistry | Applied Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Organic/Inorganic Chemistry | Physical Chemistry

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ACS Biomaterials Science & Engineering

Mimicking the Bioactivity of Fibroblast Growth Factor-2 Using Supramolecular Nanoribbons
Open Access Through ACS Editors’ Choice
ACS Biomater. Sci. Eng., 2017, 3 (9), pp 2166–2175
DOI: 10.1021/acsbiomaterials.7b00347

Special Issue on Tissue Engineering
This article is part of the Tissue Engineering special issue
ACS Biomater. Sci. Eng., 2017, 3 (9), pp 1880–1883
DOI: 10.1021/acsbiomaterials.7b00604

AFM-Nanomechanical Test: An Interdisciplinary Tool That Links the Understanding of Cartilage and Meniscus Biomechanics, Osteoarthritis Degeneration, and Tissue Engineering
ACS Biomater. Sci. Eng., 2017, 3 (9), pp 2033–2049
DOI: 10.1021/acsbiomaterials.7b00307

3D Printing of Regenerated Silk Fibroin and Antibody-Containing Microstructures via Multiphoton Lithography
ACS Biomater. Sci. Eng., 2017, 3 (9), pp 2064–2075
DOI: 10.1021/acsbiomaterials.7b00338

Controlled Release of Nitric Oxide from Liposomes
ACS Biomater. Sci. Eng., 2017, 3 (9), pp 2136–2143
DOI: 10.1021/acsbiomaterials.7b00255

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ACS Catalysis

Best Practices in Pursuit of Topics in Heterogeneous Electrocatalysis
ACS Catal., 2017, 7 (9), pp 6392–6393
DOI: 10.1021/acscatal.7b02839

Copper Cobalt Sulfide Nanosheets Realizing a Promising Electrocatalytic Oxygen Evolution Reaction
Open Access Through ACS AuthorChoice
ACS Catal., 2017, 7 (9), pp 5871–5879
DOI: 10.1021/acscatal.7b01831

Beyond C2 and C3: Transition-Metal-Catalyzed C–H Functionalization of Indole
ACS Catal., 2017, 7 (9), pp 5618–5627
DOI: 10.1021/acscatal.7b01785

Manganese-Catalyzed Sequential Hydrogenation of CO2 to Methanol via Formamide
ACS Catal., 2017, 7 (9), pp 6347–6351
DOI: 10.1021/acscatal.7b02066

Phosphonate-Based Metal–Organic Framework Derived Co–P–C Hybrid as an Efficient Electrocatalyst for Oxygen Evolution Reaction
ACS Catal., 2017, 7 (9), pp 6000–6007
DOI: 10.1021/acscatal.7b00937

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ACS Chemical Biology

Enzyme That Makes You Cry–Crystal Structure of Lachrymatory Factor Synthase from Allium cepa
ACS Chem. Biol., 2017, 12 (9), pp 2296–2304
DOI: 10.1021/acschembio.7b00336

Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
ACS Chem. Biol., 2017, 12 (9), pp 2324–2334
DOI: 10.1021/acschembio.7b00459

Small Molecule Enhancement of 20S Proteasome Activity Targets Intrinsically Disordered Proteins
ACS Chem. Biol., 2017, 12 (9), pp 2240–2247
DOI: 10.1021/acschembio.7b00489

Structure–Activity Relationships Reveal Key Features of 8-Oxoguanine: A Mismatch Detection by the MutY Glycosylase
Open Access Through ACS Editors’ Choice
ACS Chem. Biol., 2017, 12 (9), pp 2335–2344
DOI: 10.1021/acschembio.7b00389

Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8
ACS Chem. Biol., 2017, 12 (9), pp 2281–2286
DOI: 10.1021/acschembio.7b00330

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ACS Chemical Neuroscience

Classics in Neuroimaging: Imaging the Dopaminergic Pathway with PET
ACS Chem. Neurosci., 2017, 8 (9), pp 1817–1819
DOI: 10.1021/acschemneuro.7b00252

Emerging Data Strengthens the Argument That the Microbiome Is the Fifth Horseman of the Drug Discovery Apocalypse
ACS Chem. Neurosci., 2017, 8 (9), pp 1813–1813
DOI: 10.1021/acschemneuro.7b00295

Call for Papers: DARK Classics in Chemical Neuroscience
ACS Chem. Neurosci., 2017, 8 (9), pp 1812–1812
DOI: 10.1021/acschemneuro.7b00306

Eosinophilic Meningitis Caused by Angiostrongylus cantonensis
ACS Chem. Neurosci., 2017, 8 (9), pp 1815–1816
DOI: 10.1021/acschemneuro.7b00233

Angiostrongyliasis (Rat Lungworm Disease): Viewpoints from Hawai‘i Island
ACS Chem. Neurosci., 2017, 8 (9), pp 1820–1822
DOI: 10.1021/acschemneuro.7b00299
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ACS Infectious Diseases

Hydrophilic Phage-Mimicking Membrane Active Antimicrobials Reveal Nanostructure-Dependent Activity and Selectivity
Open Access Through ACS Editors’ Choice
ACS Infect. Dis., 2017, 3 (9), pp 676–687
DOI: 10.1021/acsinfecdis.7b00076

Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells
Open Access Through ACS AuthorChoice
ACS Infect. Dis., 2017, 3 (9), pp 634–644
DOI: 10.1021/acsinfecdis.7b00028

Catabolism of the Cholesterol Side Chain in Mycobacterium tuberculosis Is Controlled by a Redox-Sensitive Thiol Switch
ACS Infect. Dis., 2017, 3 (9), pp 666–675
DOI: 10.1021/acsinfecdis.7b00072

Entry Inhibitors: A Perspective for Prevention of Hepatitis C Virus Infection in Organ Transplantation
ACS Infect. Dis., 2017, 3 (9), pp 620–623
DOI: 10.1021/acsinfecdis.7b00091

Structural and Functional Survey of Environmental Aminoglycoside Acetyltransferases Reveals Functionality of Resistance Enzymes
ACS Infect. Dis., 2017, 3 (9), pp 653–665
DOI: 10.1021/acsinfecdis.7b00068

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ACS Medicinal Chemistry Letters

Medicinal Chemistry: Where Are All the Women?
ACS Med. Chem. Lett., 2017, 8 (9), pp 900–902
DOI: 10.1021/acsmedchemlett.7b00321

Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors
ACS Med. Chem. Lett., 2017, 8 (9), pp 975–980
DOI: 10.1021/acsmedchemlett.7b00293

Mitragyna speciosa: Balancing Potential Medical Benefits and Abuse
ACS Med. Chem. Lett., 2017, 8 (9), pp 897–899
DOI: 10.1021/acsmedchemlett.7b00298

Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists
ACS Med. Chem. Lett., 2017, 8 (9), pp 981–986
DOI: 10.1021/acsmedchemlett.7b00315

Design, Synthesis, and Evaluation of Tetrahydropyrrolo[1,2-c]pyrimidines as Capsid Assembly Inhibitors for HBV Treatment
ACS Med. Chem. Lett., 2017, 8 (9), pp 969–974
DOI: 10.1021/acsmedchemlett.7b00288

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ACS Synthetic Biology

Targeting Specificity of the CRISPR/Cas9 System
ACS Synth. Biol., 2017, 6 (9), pp 1609–1613
DOI: 10.1021/acssynbio.7b00270

Engineered Assimilation of Exogenous and Endogenous Formate in Escherichia coli
Open Access Through ACS AuthorChoice
ACS Synth. Biol., 2017, 6 (9), pp 1722–1731
DOI: 10.1021/acssynbio.7b00086

A Fluorescent Split Aptamer for Visualizing RNA–RNA Assembly In Vivo
Open Access Through ACS AuthorChoice
ACS Synth. Biol., 2017, 6 (9), pp 1710–1721
DOI: 10.1021/acssynbio.7b00059

Establishing an Artificial Pathway for De Novo Biosynthesis of Vanillyl Alcohol in Escherichia coli
ACS Synth. Biol., 2017, 6 (9), pp 1784–1792
DOI: 10.1021/acssynbio.7b00129

Introducing Our Authors
ACS Synth. Biol., 2017, 6 (9), pp 1607–1608
DOI: 10.1021/acssynbio.7b00320

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Biochemistry

A New Nucleoside Antibiotic Chokes Bacterial RNA Polymerase
Biochemistry, 2017, 56 (37), pp 4923–4924
DOI: 10.1021/acs.biochem.7b00680

Though Much Is Taken, Much Abides: Finding New Antibiotics Using Old Ones
Biochemistry, 2017, 56 (37), pp 4925–4926
DOI: 10.1021/acs.biochem.7b00782

Transmembrane Proteins: Amyloids Hidden in Plain Sight?
Biochemistry, 2017, 56 (36), pp 4735–4736
DOI: 10.1021/acs.biochem.7b00758

Enzymatic Cross-Linking of Side Chains Generates a Modified Peptide with Four Hairpin-like Bicyclic Repeats
Open Access Through ACS Editors’ Choice
Biochemistry, 2017, 56 (37), pp 4927–4930
DOI: 10.1021/acs.biochem.7b00808

Iron–Sulfur Cluster States of the Hydrogenase Maturase HydF
Biochemistry, 2017, 56 (36), pp 4733–4734
DOI: 10.1021/acs.biochem.7b00735

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Bioconjugate Chemistry

89Zr-Immuno-Positron Emission Tomography in Oncology: State-of-the-Art 89Zr Radiochemistry
Open Access Through ACS AuthorChoice
Bioconjugate Chem., 2017, 28 (9), pp 2211–2223
DOI: 10.1021/acs.bioconjchem.7b00325

Site-Specific Conjugation to Native and Engineered Lysines in Human Immunoglobulins by Microbial Transglutaminase
Bioconjugate Chem., 2017, 28 (9), pp 2471–2484
DOI: 10.1021/acs.bioconjchem.7b00439

Diels–Alder “Clickable” Biodegradable Nanofibers: Benign Tailoring of Scaffolds for Biomolecular Immobilization and Cell Growth
Bioconjugate Chem., 2017, 28 (9), pp 2420–2428
DOI: 10.1021/acs.bioconjchem.7b00411

Dynamic Covalent Hydrogels for Triggered Cell Capture and Release
Bioconjugate Chem., 2017, 28 (9), pp 2235–2240
DOI: 10.1021/acs.bioconjchem.7b00360

Detection of Alkynes via Click Chemistry with a Brominated Coumarin Azide by Simultaneous Fluorescence and Isotopic Signatures in Mass Spectrometry
Bioconjugate Chem., 2017, 28 (9), pp 2302–2309
DOI: 10.1021/acs.bioconjchem.7b00354

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Biomacromolecules

3D Printing Polymers with Supramolecular Functionality for Biological Applications
Biomacromolecules, 2017, 18 (9), pp 2669–2687
DOI: 10.1021/acs.biomac.7b00671

pH-Responsive Poly(Ethylene Glycol)-block-Polylactide Micelles for Tumor-Targeted Drug Delivery
Biomacromolecules, 2017, 18 (9), pp 2711–2722
DOI: 10.1021/acs.biomac.7b00509

Tunicate-Inspired Gallol Polymers for Underwater Adhesive: A Comparative Study of Catechol and Gallol
Biomacromolecules, 2017, 18 (9), pp 2959–2966
DOI: 10.1021/acs.biomac.7b00921

Effect of Molecular Architecture on Cell Interactions and Stealth Properties of PEG
Biomacromolecules, 2017, 18 (9), pp 2699–2710
DOI: 10.1021/acs.biomac.7b00443

Tunable, Injectable Hydrogels Based on Peptide-Cross-Linked, Cyclized Polymer Nanoparticles for Neural Progenitor Cell Delivery
Biomacromolecules, 2017, 18 (9), pp 2723–2731
DOI: 10.1021/acs.biomac.7b00510

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Journal of Agricultural and Food Chemistry

Persistent Luminescence Nanophosphor Involved Near-Infrared Optical Bioimaging for Investigation of Foodborne Probiotics Biodistribution in Vivo: A Proof-of-Concept Study
Open Access Through ACS Editors’ Choice
J. Agric. Food Chem., 2017, 65 (37), pp 8229–8240
DOI: 10.1021/acs.jafc.7b02870

Purification and Characterization of Latent Polyphenol Oxidase from Apricot (Prunus armeniaca L.)
Open Access Through ACS AuthorChoice
J. Agric. Food Chem., 2017, 65 (37), pp 8203–8212
DOI: 10.1021/acs.jafc.7b03210

Mechanisms for Increasing the pH Buffering Capacity of an Acidic Ultisol by Crop Residue-Derived Biochars
J. Agric. Food Chem., 2017, 65 (37), pp 8111–8119
DOI: 10.1021/acs.jafc.7b02266

Advances in Polyphenol Research: A Journal of Agricultural and Food Chemistry Virtual Issue
J. Agric. Food Chem., 2017, 65 (37), pp 8093–8095
DOI: 10.1021/acs.jafc.7b04055

The Nutritive Value of Organic and Conventional White Cabbage (Brassica Oleracea L. Var. Capitata) and Anti-Apoptotic Activity in Gastric Adenocarcinoma Cells of Sauerkraut Juice Produced Therof
J. Agric. Food Chem., 2017, 65 (37), pp 8171–8183
DOI: 10.1021/acs.jafc.7b01078

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Journal of Chemical Theory and Computation

Machine Learning Force Field Parameters from Ab Initio Data
J. Chem. Theory Comput., 2017, 13 (9), pp 4492–4503
DOI: 10.1021/acs.jctc.7b00521

Coarse-Grained Directed Simulation
J. Chem. Theory Comput., 2017, 13 (9), pp 4593–4603
DOI: 10.1021/acs.jctc.7b00690

Conceptual Problem with Calculating Electron Densities in Finite Basis Density Functional Theory
J. Chem. Theory Comput., 2017, 13 (9), pp 3961–3963
DOI: 10.1021/acs.jctc.7b00562

POVME 3.0: Software for Mapping Binding Pocket Flexibility
J. Chem. Theory Comput., 2017, 13 (9), pp 4584–4592
DOI: 10.1021/acs.jctc.7b00500

Characterization of Ciprofloxacin Permeation Pathways across the Porin OmpC Using Metadynamics and a String Method
J. Chem. Theory Comput., 2017, 13 (9), pp 4553–4566
DOI: 10.1021/acs.jctc.7b00467

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Journal of Medicinal Chemistry

5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology
Open Access Through ACS AuthorChoice
J. Med. Chem., 2017, 60 (17), pp 7524–7538
DOI: 10.1021/acs.jmedchem.7b00930

Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders
J. Med. Chem., 2017, 60 (18), pp 7677–7702
DOI: 10.1021/acs.jmedchem.7b00807

Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders
J. Med. Chem., 2017, 60 (18), pp 7658–7676
DOI: 10.1021/acs.jmedchem.7b00709

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi
Open Access Through ACS Editors’ Choice
J. Med. Chem., 2017, 60 (17), pp 7284–7299
DOI: 10.1021/acs.jmedchem.7b00463

Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor
J. Med. Chem., 2017, 60 (18), pp 7725–7744
DOI: 10.1021/acs.jmedchem.7b00515

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Journal of Natural Products

Bioassay-Guided Isolation of Antibacterial Metabolites from Emericella sp. TJ29
J. Nat. Prod., 2017, 80 (9), pp 2399–2405
DOI: 10.1021/acs.jnatprod.7b00077

Lamellodysidines A and B, Sesquiterpenes Isolated from the Marine Sponge Lamellodysidea herbacea
J. Nat. Prod., 2017, 80 (9), pp 2536–2541
DOI: 10.1021/acs.jnatprod.7b00610

The Face of a Molecule
J. Nat. Prod., 2017, 80 (9), pp 2583–2588
DOI: 10.1021/acs.jnatprod.7b00624

6,7-Seco-ent-Kauranoids Derived from Oridonin as Potential Anticancer Agents
J. Nat. Prod., 2017, 80 (9), pp 2391–2398
DOI: 10.1021/acs.jnatprod.7b00057

Review of Natural Products Isolation
J. Nat. Prod., 2017, 80 (9), pp 2590–2590
DOI: 10.1021/acs.jnatprod.7b00710

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The Journal of Physical Chemistry B

Role of Electrostatics in Protein–RNA Binding: The Global vs the Local Energy Landscape
J. Phys. Chem. B, 2017, 121 (36), pp 8437–8446
DOI: 10.1021/acs.jpcb.7b04318

Combining Graphical and Analytical Methods with Molecular Simulations To Analyze Time-Resolved FRET Measurements of Labeled Macromolecules Accurately
Open Access Through ACS AuthorChoice
J. Phys. Chem. B, 2017, 121 (35), pp 8211–8241
DOI: 10.1021/acs.jpcb.7b03441

Modeling of Polyelectrolyte Adsorption from Micellar Solutions onto Biomimetic Substrates
Open Access Through ACS AuthorChoice
J. Phys. Chem. B, 2017, 121 (37), pp 8638–8651
DOI: 10.1021/acs.jpcb.7b05195

Not All β-Sheets Are the Same: Amyloid Infrared Spectra, Transition Dipole Strengths, and Couplings Investigated by 2D IR Spectroscopy
J. Phys. Chem. B, 2017, 121 (38), pp 8935–8945
DOI: 10.1021/acs.jpcb.7b06826

Super-Resolution Far-Field Infrared Imaging by Photothermal Heterodyne Imaging
Open Access Through ACS AuthorChoice
J. Phys. Chem. B, 2017, 121 (37), pp 8838–8846
DOI: 10.1021/acs.jpcb.7b06065

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The Journal of Physical Chemistry Letters

High-Quality (CH3NH3)3Bi2I9 Film-Based Solar Cells: Pushing Efficiency up to 1.64%
Open Access Through ACS Editors’ Choice
J. Phys. Chem. Lett., 2017, 8 (17), pp 4300–4307
DOI: 10.1021/acs.jpclett.7b01952

(C6H5C2H4NH3)2GeI4: A Layered Two-Dimensional Perovskite with Potential for Photovoltaic Applications
J. Phys. Chem. Lett., 2017, 8 (18), pp 4402–4406
DOI: 10.1021/acs.jpclett.7b01985

Thioamide, a Hydrogen Bond Acceptor in Proteins and Nucleic Acids
J. Phys. Chem. Lett., 2017, 8 (18), pp 4573–4579
DOI: 10.1021/acs.jpclett.7b01810

A Chiral Gas–Hydrate Structure Common to the Carbon Dioxide–Water and Hydrogen–Water Systems
Open Access Through ACS Editors’ Choice
J. Phys. Chem. Lett., 2017, 8 (17), pp 4295–4299
DOI: 10.1021/acs.jpclett.7b01787

Ultrafast Microscopy: Imaging Light with Photoelectrons on the Nano–Femto Scale
J. Phys. Chem. Lett., 2017, 8 (18), pp 4446–4455
DOI: 10.1021/acs.jpclett.7b00904

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Journal of Proteome Research

Evaluation of Parameters for Confident Phosphorylation Site Localization Using an Orbitrap Fusion Tribrid Mass Spectrometer
Open Access Through ACS AuthorChoice
J. Proteome Res., 2017, 16 (9), pp 3448–3459
DOI: 10.1021/acs.jproteome.7b00337

Statistical Models for the Analysis of Isobaric Tags Multiplexed Quantitative Proteomics
J. Proteome Res., 2017, 16 (9), pp 3124–3136
DOI: 10.1021/acs.jproteome.6b01050

Optimizing High-Resolution Mass Spectrometry for the Identification of Low-Abundance Post-Translational Modifications of Intact Proteins
J. Proteome Res., 2017, 16 (9), pp 3255–3265
DOI: 10.1021/acs.jproteome.7b00244

Blood Metabolic Signatures of Body Mass Index: A Targeted Metabolomics Study in the EPIC Cohort
J. Proteome Res., 2017, 16 (9), pp 3137–3146
DOI: 10.1021/acs.jproteome.6b01062

The Impact of Commonly Used Alkylating Agents on Artifactual Peptide Modification
J. Proteome Res., 2017, 16 (9), pp 3443–3447
DOI: 10.1021/acs.jproteome.7b00022

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Molecular Pharmaceutics

Bioavailability of Polyphenols and Flavonoids in the Era of Precision Medicine
This article is part of the Bioavailability of Polyphenols and Flavonoids in the Era of Precision Medicine special issue
Mol. Pharmaceutics, 2017, 14 (9), pp 2861–2863
DOI: 10.1021/acs.molpharmaceut.7b00545

Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes
Open Access Through ACS AuthorChoice
Mol. Pharmaceutics, 2017, 14 (9), pp 3142–3151
DOI: 10.1021/acs.molpharmaceut.7b00364

druGAN: An Advanced Generative Adversarial Autoencoder Model for de Novo Generation of New Molecules with Desired Molecular Properties in Silico
Mol. Pharmaceutics, 2017, 14 (9), pp 3098–3104
DOI: 10.1021/acs.molpharmaceut.7b00346

Apoferritin Nanocage for Brain Targeted Doxorubicin Delivery
Mol. Pharmaceutics, 2017, 14 (9), pp 3087–3097
DOI: 10.1021/acs.molpharmaceut.7b00341

Intraperitoneal Delivery of Cisplatin via a Hyaluronan-Based Nanogel/in Situ Cross-Linkable Hydrogel Hybrid System for Peritoneal Dissemination of Gastric Cancer
Mol. Pharmaceutics, 2017, 14 (9), pp 3105–3113
DOI: 10.1021/acs.molpharmaceut.7b00349

If you have comments or questions for the author of this post, please e-mail: Axial@acs.org.