Discover the Most-Read Organic/Inorganic Chemistry Articles of September 2017

What were chemists reading in September of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each organic and inorganic chemistry ACS Publications journal in September 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great September 2017 Chemistry Research:

Analytical Chemistry | Applied Chemistry | Biological Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Physical Chemistry

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ACS Catalysis

Best Practices in Pursuit of Topics in Heterogeneous Electrocatalysis
ACS Catal., 2017, 7 (9), pp 6392–6393
DOI: 10.1021/acscatal.7b02839

Copper Cobalt Sulfide Nanosheets Realizing a Promising Electrocatalytic Oxygen Evolution Reaction
Open Access Through ACS  AuthorChoice
ACS Catal., 2017, 7 (9), pp 5871–5879
DOI: 10.1021/acscatal.7b01831

Beyond C2 and C3: Transition-Metal-Catalyzed C–H Functionalization of Indole
ACS Catal., 2017, 7 (9), pp 5618–5627
DOI: 10.1021/acscatal.7b01785

Manganese-Catalyzed Sequential Hydrogenation of CO2 to Methanol via Formamide
ACS Catal., 2017, 7 (9), pp 6347–6351
DOI: 10.1021/acscatal.7b02066

Phosphonate-Based Metal–Organic Framework Derived Co–P–C Hybrid as an Efficient Electrocatalyst for Oxygen Evolution Reaction
ACS Catal., 2017, 7 (9), pp 6000–6007
DOI: 10.1021/acscatal.7b00937

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ACS Combinatorial Science

An Efficient One-Pot Synthesis of Densely Functionalized Fused-Quinolines via Sequential Ugi4CC and Acid-Mediated Povarov-Type Reaction
ACS Comb. Sci., 2017, 19 (9), pp 600–608
DOI: 10.1021/acscombsci.7b00095

Selection of Effective HTRA3 Activators Using Combinatorial Chemistry
ACS Comb. Sci., 2017, 19 (9), pp 565–573
DOI: 10.1021/acscombsci.7b00051

Fabrication of TiO2-Reduced Graphene Oxide Nanorod Composition Spreads Using Combinatorial Hydrothermal Synthesis and Their Photocatalytic and Photoelectrochemical Applications
ACS Comb. Sci., 2017, 19 (9), pp 585–593
DOI: 10.1021/acscombsci.7b00077

Shape Memory Micro- and Nanowire Libraries for the High-Throughput Investigation of Scaling Effects
ACS Comb. Sci., 2017, 19 (9), pp 574–584
DOI: 10.1021/acscombsci.7b00065

Fabrication of a New Lineage of Artificial Luciferases from Natural Luciferase Pools
ACS Comb. Sci., 2017, 19 (9), pp 594–599
DOI: 10.1021/acscombsci.7b00081

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ACS Medicinal Chemistry Letters

Medicinal Chemistry: Where Are All the Women?
ACS Med. Chem. Lett., 2017, 8 (9), pp 900–902
DOI: 10.1021/acsmedchemlett.7b00321

Discovery of CDZ173 (Leniolisib), Representing a Structurally Novel Class of PI3K Delta-Selective Inhibitors
ACS Med. Chem. Lett., 2017, 8 (9), pp 975–980
DOI: 10.1021/acsmedchemlett.7b00293

Mitragyna speciosa: Balancing Potential Medical Benefits and Abuse
ACS Med. Chem. Lett., 2017, 8 (9), pp 897–899
DOI: 10.1021/acsmedchemlett.7b00298

Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists
ACS Med. Chem. Lett., 2017, 8 (9), pp 981–986
DOI: 10.1021/acsmedchemlett.7b00315

Design, Synthesis, and Evaluation of Tetrahydropyrrolo[1,2-c]pyrimidines as Capsid Assembly Inhibitors for HBV Treatment
ACS Med. Chem. Lett., 2017, 8 (9), pp 969–974
DOI: 10.1021/acsmedchemlett.7b00288

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Bioconjugate Chemistry

89Zr-Immuno-Positron Emission Tomography in Oncology: State-of-the-Art 89Zr Radiochemistry
Open Access Through ACS AuthorChoice
Bioconjugate Chem., 2017, 28 (9), pp 2211–2223
DOI: 10.1021/acs.bioconjchem.7b00325

Site-Specific Conjugation to Native and Engineered Lysines in Human Immunoglobulins by Microbial Transglutaminase
Bioconjugate Chem., 2017, 28 (9), pp 2471–2484
DOI: 10.1021/acs.bioconjchem.7b00439

Diels–Alder “Clickable” Biodegradable Nanofibers: Benign Tailoring of Scaffolds for Biomolecular Immobilization and Cell Growth
Bioconjugate Chem., 2017, 28 (9), pp 2420–2428
DOI: 10.1021/acs.bioconjchem.7b00411

Dynamic Covalent Hydrogels for Triggered Cell Capture and Release
Bioconjugate Chem., 2017, 28 (9), pp 2235–2240
DOI: 10.1021/acs.bioconjchem.7b00360

Detection of Alkynes via Click Chemistry with a Brominated Coumarin Azide by Simultaneous Fluorescence and Isotopic Signatures in Mass Spectrometry
Bioconjugate Chem., 2017, 28 (9), pp 2302–2309
DOI: 10.1021/acs.bioconjchem.7b00354

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Inorganic Chemistry

Magnetic Interaction Affecting the Zero-Field Single-Molecule Magnet Behaviors in Isomorphic {NiII2DyIII2} and {CoII2DyIII2} Tetranuclear Complexes
Inorg. Chem., 2017, 56 (18), pp 11387–11397
DOI: 10.1021/acs.inorgchem.7b01840

Luminescent Iridium(III) Pyridinium-Derived N-Heterocyclic Carbene Complexes as Versatile Photoredox Catalysts
Inorg. Chem., 2017, 56 (18), pp 10835–10839
DOI: 10.1021/acs.inorgchem.7b00955

Role of Ligand Protonation in Dihydrogen Evolution from a Pentamethylcyclopentadienyl Rhodium Catalyst
Inorg. Chem., 2017, 56 (18), pp 11375–11386
DOI: 10.1021/acs.inorgchem.7b01698

A Luminescent 3d-4f-4d MOF Nanoprobe as a Diagnosis Platform for Human Occupational Exposure to Vinyl Chloride Carcinogen
Inorg. Chem., 2017, 56 (18), pp 11176–11183
DOI: 10.1021/acs.inorgchem.7b01549

Open-Framework Manganese(II) and Cobalt(II) Borophosphates with Helical Chains: Structures, Magnetic, and Luminescent Properties
Inorg. Chem., 2017, 56 (18), pp 11104–11112
DOI: 10.1021/acs.inorgchem.7b01423

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Journal of Medicinal Chemistry

5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology
Open Access Through ACS AuthorChoice
J. Med. Chem., 2017, 60 (17), pp 7524–7538
DOI: 10.1021/acs.jmedchem.7b00930

Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders
J. Med. Chem., 2017, 60 (18), pp 7677–7702
DOI: 10.1021/acs.jmedchem.7b00807

Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders
J. Med. Chem., 2017, 60 (18), pp 7658–7676
DOI: 10.1021/acs.jmedchem.7b00709

Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi
Open Access Through ACS Editors’ Choice
J. Med. Chem., 2017, 60 (17), pp 7284–7299
DOI: 10.1021/acs.jmedchem.7b00463

Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor
J. Med. Chem., 2017, 60 (18), pp 7725–7744
DOI: 10.1021/acs.jmedchem.7b00515

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Journal of Natural Products

Bioassay-Guided Isolation of Antibacterial Metabolites from Emericella sp. TJ29
J. Nat. Prod., 2017, 80 (9), pp 2399–2405
DOI: 10.1021/acs.jnatprod.7b00077

Lamellodysidines A and B, Sesquiterpenes Isolated from the Marine Sponge Lamellodysidea herbacea
J. Nat. Prod., 2017, 80 (9), pp 2536–2541
DOI: 10.1021/acs.jnatprod.7b00610

The Face of a Molecule
J. Nat. Prod., 2017, 80 (9), pp 2583–2588
DOI: 10.1021/acs.jnatprod.7b00624

6,7-Seco-ent-Kauranoids Derived from Oridonin as Potential Anticancer Agents
J. Nat. Prod., 2017, 80 (9), pp 2391–2398
DOI: 10.1021/acs.jnatprod.7b00057

Review of Natural Products Isolation
J. Nat. Prod., 2017, 80 (9), pp 2590–2590
DOI: 10.1021/acs.jnatprod.7b00710

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The Journal of Organic Chemistry

Trifluoromethanesulfonate Anion as Nucleophile in Organic Chemistry
J. Org. Chem., 2017, 82 (18), pp 9263–9269
DOI: 10.1021/acs.joc.7b01850

Synthesis of Azobenzenes Using N-Chlorosuccinimide and 1,8-Diazabicyclo[5.4.0]undec-7-ene (DBU)
J. Org. Chem., 2017, 82 (18), pp 9873–9876
DOI: 10.1021/acs.joc.7b01530

Lewis Acid-Mediated Site-Selective Synthesis of Oxygenated Biaryls from Methoxyphenols and Electron-Rich Arenes
J. Org. Chem., 2017, 82 (18), pp 9367–9383
DOI: 10.1021/acs.joc.7b00684

Copper-Catalyzed TBHP-Mediated Radical Cross-Coupling Reaction of Sulfonylhydrazides with Thiols Leading to Thiosulfonates
J. Org. Chem., 2017, 82 (18), pp 9801–9807
DOI: 10.1021/acs.joc.7b01121

A Total Synthesis of the Marine Alkaloid Discoipyrrole D
J. Org. Chem., 2017, 82 (18), pp 9328–9334
DOI: 10.1021/acs.joc.7b01192

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Molecular Pharmaceutics

Bioavailability of Polyphenols and Flavonoids in the Era of Precision Medicine
This article is part of the Bioavailability of Polyphenols and Flavonoids in the Era of Precision Medicine special issue
Mol. Pharmaceutics, 2017, 14 (9), pp 2861–2863
DOI: 10.1021/acs.molpharmaceut.7b00545

Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes
Open Access Through ACS AuthorChoice
Mol. Pharmaceutics, 2017, 14 (9), pp 3142–3151
DOI: 10.1021/acs.molpharmaceut.7b00364

druGAN: An Advanced Generative Adversarial Autoencoder Model for de Novo Generation of New Molecules with Desired Molecular Properties in Silico
Mol. Pharmaceutics, 2017, 14 (9), pp 3098–3104
DOI: 10.1021/acs.molpharmaceut.7b00346

Apoferritin Nanocage for Brain Targeted Doxorubicin Delivery
Mol. Pharmaceutics, 2017, 14 (9), pp 3087–3097
DOI: 10.1021/acs.molpharmaceut.7b00341

Intraperitoneal Delivery of Cisplatin via a Hyaluronan-Based Nanogel/in Situ Cross-Linkable Hydrogel Hybrid System for Peritoneal Dissemination of Gastric Cancer
Mol. Pharmaceutics, 2017, 14 (9), pp 3105–3113
DOI: 10.1021/acs.molpharmaceut.7b00349

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Organic Letters

Transition-Metal-Free Quinoline Synthesis from Acetophenones and Anthranils via Sequential One-Carbon Homologation/Conjugate Addition/Annulation Cascade
Org. Lett., 2017, 19 (18), pp 4948–4951
DOI: 10.1021/acs.orglett.7b02429

γ-Amino Butyric Acid (GABA) Synthesis Enabled by Copper-Catalyzed Carboamination of Alkenes
Org. Lett., 2017, 19 (18), pp 4718–4721
DOI: 10.1021/acs.orglett.7b01969

Total Synthesis of (+)-Aplykurodinone-1
Org. Lett., 2017, 19 (18), pp 4861–4863
DOI: 10.1021/acs.orglett.7b02350

Azidofluoroalkylation of Alkenes with Simple Fluoroalkyl Iodides Enabled by Photoredox Catalysis
Org. Lett., 2017, 19 (18), pp 4738–4741
DOI: 10.1021/acs.orglett.7b02056

Direct Synthesis of 4-Quinolones via Copper-Catalyzed Anilines and Alkynes
Org. Lett., 2017, 19 (18), pp 4984–4987
DOI: 10.1021/acs.orglett.7b02495

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Organic Process Research & Development

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2017, 21 (9), pp 1196–1208
DOI: 10.1021/acs.oprd.7b00286

General Principles and Strategies for Salting-Out Informed by the Hofmeister Series
Open Access Through ACS AuthorChoice
Org. Process Res. Dev., 2017, 21 (9), pp 1355–1370
DOI: 10.1021/acs.oprd.7b00197

Development of a Leuckart–Wallach Reaction in Flow for the Synthesis of Abemaciclib
Open Access Through ACS Editors’ Choice
Org. Process Res. Dev., 2017, 21 (9), pp 1447–1451
DOI: 10.1021/acs.oprd.7b00234

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2017, 21 (9), pp 1187–1195
DOI: 10.1021/acs.oprd.7b00251

Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times
Open Access Through ACS Editors’ Choice
Org. Process Res. Dev., 2017, 21 (9), pp 1294–1301
DOI: 10.1021/acs.oprd.7b00173

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Organometallics

Catalysis of Cross-Coupling and Homocoupling Reactions of Aryl Halides Utilizing Ni(0), Ni(I), and Ni(II) Precursors; Ni(0) Compounds as the Probable Catalytic Species but Ni(I) Compounds as Intermediates and Products
Organometallics, 2017, 36 (18), pp 3508–3519
DOI: 10.1021/acs.organomet.7b00446

Direct Synthesis of a Copper(II) N-Heterocyclic Carbene Complex in Air
Organometallics, 2017, 36 (17), pp 3175–3177
DOI: 10.1021/acs.organomet.7b00489

Expedient Syntheses of Neutral and Cationic Au(I)–NHC Complexes
Organometallics, 2017, 36 (18), pp 3645–3653
DOI: 10.1021/acs.organomet.7b00622

Dimeric Ruthenium(II)-NNN Complex Catalysts Bearing a Pyrazolyl-Pyridylamino-Pyridine Ligand for Transfer Hydrogenation of Ketones and Acceptorless Dehydrogenation of Alcohols
Organometallics, 2017, 36 (18), pp 3638–3644
DOI: 10.1021/acs.organomet.7b00587

Regioselective Ring Opening Reactions of Pyridine N-Oxide Analogues by Magnesium Hydride Complexes
Organometallics, 2017, 36 (18), pp 3597–3604
DOI: 10.1021/acs.organomet.7b00517

If you have comments or questions for the author of this post, please e-mail: Axial@acs.org.