Discover the Most-Read Biological Chemistry Articles of October 2017

What were chemists reading in October of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each biological chemistry ACS Publications journal in October 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great October 2017 Chemistry Research:

Analytical Chemistry | Applied ChemistryMaterials Science & Engineering | Multidisciplinary Chemistry | Organic/Inorganic Chemistry | Physical Chemistry
***

ACS Biomaterials Science & Engineering

ZnO–DOX@ZIF-8 Core–Shell Nanoparticles for pH-Responsive Drug Delivery
ACS Biomater. Sci. Eng., 2017, 3 (10), pp 2223–2229
DOI: 10.1021/acsbiomaterials.7b00435

Supramolecular Hydrogel Inspired from DNA Structures Mimics Peroxidase Activity
ACS Biomater. Sci. Eng., 2017, 3 (10), pp 2358–2365
DOI: 10.1021/acsbiomaterials.7b00563

Femtosecond-Laser-Based 3D Printing for Tissue Engineering and Cell Biology Applications
ACS Biomater. Sci. Eng., 2017, 3 (10), pp 2198–2214
DOI: 10.1021/acsbiomaterials.7b00438

Overcoming Multidrug Resistance through the Synergistic Effects of Hierarchical pH-Sensitive, ROS-Generating Nanoreactors
ACS Biomater. Sci. Eng., 2017, 3 (10), pp 2431–2442
DOI: 10.1021/acsbiomaterials.7b00569

Biodegradable and Magnetic-Fluorescent Porous Silicon@Iron Oxide Nanocomposites for Fluorescence/Magnetic Resonance Bimodal Imaging of Tumor in Vivo
ACS Biomater. Sci. Eng., 2017, 3 (10), pp 2579–2587
DOI: 10.1021/acsbiomaterials.7b00467

***

ACS Catalysis

Nickel-Based Electrocatalysts for Energy-Related Applications: Oxygen Reduction, Oxygen Evolution, and Hydrogen Evolution Reactions
ACS Catal., 2017, 7 (10), pp 7196–7225
DOI: 10.1021/acscatal.7b01800

Accounting for Bifurcating Pathways in the Screening for CO2 Reduction Catalysts
ACS Catal., 2017, 7 (10), pp 7346–7351
DOI: 10.1021/acscatal.7b02917

Increasing Oxide Reducibility: The Role of Metal/Oxide Interfaces in the Formation of Oxygen Vacancies
Open Access Through ACS AuthorChoice.
ACS Catal., 2017, 7 (10), pp 6493–6513
DOI: 10.1021/acscatal.7b01913

Visible-Light Photocatalytic Decarboxylation of α,β-Unsaturated Carboxylic Acids: Facile Access to Stereoselective Difluoromethylated Styrenes in Batch and Flow
Open Access Through ACS AuthorChoice.
ACS Catal., 2017, 7 (10), pp 7136–7140
DOI: 10.1021/acscatal.7b03019

Vertically Aligned MoS2/Mo2C hybrid Nanosheets Grown on Carbon Paper for Efficient Electrocatalytic Hydrogen Evolution
ACS Catal., 2017, 7 (10), pp 7312–7318
DOI: 10.1021/acscatal.7b02885

***

ACS Chemical Biology

Ionic Strength Sensing in Living Cells
Open Access Through ACS AuthorChoice.
ACS Chem. Biol., 2017, 12 (10), pp 2510–2514
DOI: 10.1021/acschembio.7b00348

Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics
ACS Chem. Biol., 2017, 12 (10), pp 2671–2681
DOI: 10.1021/acschembio.7b00581

Live Cell Imaging of Mitochondrial Autophagy with a Novel Fluorescent Small Molecule
ACS Chem. Biol., 2017, 12 (10), pp 2546–2551
DOI: 10.1021/acschembio.7b00647

Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation
ACS Chem. Biol., 2017, 12 (10), pp 2570–2578
DOI: 10.1021/acschembio.7b00485

Functional Analysis of Cytochrome P450s Involved in Streptovaricin Biosynthesis and Generation of Anti-MRSA Analogues
ACS Chem. Biol., 2017, 12 (10), pp 2589–2597
DOI: 10.1021/acschembio.7b00467

***

ACS Chemical Neuroscience

Why I’m Not a Cognitive Psychologist… or a Behaviorist… or a Biologist
ACS Chem. Neurosci., 2017, 8 (10), pp 2100–2101
DOI: 10.1021/acschemneuro.7b00316

Angiostrongylus cantonensis: Agent of a Sometimes Fatal Globally Emerging Infectious Disease (Rat Lungworm Disease)
ACS Chem. Neurosci., 2017, 8 (10), pp 2102–2104
DOI: 10.1021/acschemneuro.7b00335

ACS Chemical Neuroscience: Most Cited Papers from 2016
ACS Chem. Neurosci., 2017, 8 (10), pp 2097–2098
DOI: 10.1021/acschemneuro.7b00354

Receptor Targeted Polymeric Nanostructures Capable of Navigating across the Blood-Brain Barrier for Effective Delivery of Neural Therapeutics
ACS Chem. Neurosci., 2017, 8 (10), pp 2105–2117
DOI: 10.1021/acschemneuro.7b00207

Correction to Identification of a Novel 1,4,8-Triazaphenanthrene Derivative as a Neuroprotectant for Dopamine Neurons Vulnerable in Parkinson’s Disease
ACS Chem. Neurosci., 2017, 8 (10), pp 2347–2347
DOI: 10.1021/acschemneuro.7b00352

***

ACS Infectious Diseases

Thiol-Containing Metallo-β-Lactamase Inhibitors Resensitize Resistant Gram-Negative Bacteria to Meropenem
ACS Infect. Dis., 2017, 3 (10), pp 711–717
DOI: 10.1021/acsinfecdis.7b00094

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani
ACS Infect. Dis., 2017, 3 (10), pp 718–727
DOI: 10.1021/acsinfecdis.7b00047

Teixobactin and Its Analogues: A New Hope in Antibiotic Discovery
ACS Infect. Dis., 2017, 3 (10), pp 688–690
DOI: 10.1021/acsinfecdis.7b00108

Surface-Enhanced Raman Spectroscopy-Based Sandwich Immunoassays for Multiplexed Detection of Zika and Dengue Viral Biomarkers
ACS Infect. Dis., 2017, 3 (10), pp 767–776
DOI: 10.1021/acsinfecdis.7b00110

The Next Wave of Influenza Drugs
ACS Infect. Dis., 2017, 3 (10), pp 691–694
DOI: 10.1021/acsinfecdis.7b00142

***

ACS Medicinal Chemistry Letters

Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases
ACS Med. Chem. Lett., 2017, 8 (10), pp 1048–1053
DOI: 10.1021/acsmedchemlett.7b00258

Antibody–Drug Conjugates for the Treatment of Inflammation
ACS Med. Chem. Lett., 2017, 8 (10), pp 992–994
DOI: 10.1021/acsmedchemlett.7b00377

Anti-inflammatory Silent Agonists
ACS Med. Chem. Lett., 2017, 8 (10), pp 989–991
DOI: 10.1021/acsmedchemlett.7b00368

Artificial Macrocycles as Potent p53–MDM2 Inhibitors
ACS Med. Chem. Lett., 2017, 8 (10), pp 1025–1030
DOI: 10.1021/acsmedchemlett.7b00219

Indolinone Inhibitors of ENT1 for the Treatment of Schizophrenia
ACS Med. Chem. Lett., 2017, 8 (10), pp 995–996
DOI: 10.1021/acsmedchemlett.7b00378

***

ACS Synthetic Biology

Rapid and Programmable Protein Mutagenesis Using Plasmid Recombineering
ACS Synth. Biol., 2017, 6 (10), pp 1825–1833
DOI: 10.1021/acssynbio.7b00112

Fundamental Design Principles for Transcription-Factor-Based Metabolite Biosensors
ACS Synth. Biol., 2017, 6 (10), pp 1851–1859
DOI: 10.1021/acssynbio.7b00172

An Orthogonal Multi-input Integration System to Control Gene Expression in Escherichia coli
ACS Synth. Biol., 2017, 6 (10), pp 1816–1824
DOI: 10.1021/acssynbio.7b00109

Development of a Bacterial Biosensor for Rapid Screening of Yeast p-Coumaric Acid Production
ACS Synth. Biol., 2017, 6 (10), pp 1860–1869
DOI: 10.1021/acssynbio.7b00009

A Synthetic Circuit for Mercury Bioremediation Using Self-Assembling Functional Amyloids
ACS Synth. Biol., 2017, 6 (10), pp 1841–1850
DOI: 10.1021/acssynbio.7b00137

***

Biochemistry

Structural Basis for G Protein-Coupled Receptor Activation
Biochemistry, 2017, 56 (42), pp 5628–5634
DOI: 10.1021/acs.biochem.7b00747

Hop to It
Biochemistry, 2017, 56 (42), pp 5623–5624
DOI: 10.1021/acs.biochem.7b00950

Chemistry Is Dead. Long Live Chemistry!
Biochemistry, 2017, 56 (39), pp 5165–5170
DOI: 10.1021/acs.biochem.7b00529

A Vision for Vaccines: Combating the Opioid Epidemic
Biochemistry, 2017, 56 (42), pp 5625–5627
DOI: 10.1021/acs.biochem.7b00948

Cation−π Lights Up “Halo”
Biochemistry, 2017, 56 (40), pp 5221–5222
DOI: 10.1021/acs.biochem.7b00702

***

Bioconjugate Chemistry

Automated Solid-Phase Click Synthesis of Oligonucleotide Conjugates: From Small Molecules to Diverse N-Acetylgalactosamine Clusters
Bioconjugate Chem., 2017, 28 (10), pp 2599–2607
DOI: 10.1021/acs.bioconjchem.7b00462

Transglutaminase-Catalyzed Bioconjugation Using One-Pot Metal-Free Bioorthogonal Chemistry
Bioconjugate Chem., 2017, 28 (10), pp 2518–2523
DOI: 10.1021/acs.bioconjchem.7b00509

Attachment Site Cysteine Thiol pKa Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody–Drug Conjugates
Bioconjugate Chem., 2017, 28 (10), pp 2538–2548
DOI: 10.1021/acs.bioconjchem.7b00365

Polyethylene Glycol Based Changes to β-Sheet Protein Conformational and Proteolytic Stability Depend on Conjugation Strategy and Location
Bioconjugate Chem., 2017, 28 (10), pp 2507–2513
DOI: 10.1021/acs.bioconjchem.7b00281

Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots In Vivo
Bioconjugate Chem., 2017, 28 (10), pp 2608–2619
DOI: 10.1021/acs.bioconjchem.7b00466

***

Biomacromolecules

Degradable Adhesives for Surgery and Tissue Engineering
Open Access Through ACS AuthorChoice.
Biomacromolecules, 2017, 18 (10), pp 3009–3039
DOI: 10.1021/acs.biomac.7b00969

Biomimetic Stress Sensitive Hydrogel Controlled by DNA Nanoswitches
Open Access Through ACS AuthorChoice.
Biomacromolecules, 2017, 18 (10), pp 3310–3317
DOI: 10.1021/acs.biomac.7b00964

Three-Dimensional Electroconductive Hyaluronic Acid Hydrogels Incorporated with Carbon Nanotubes and Polypyrrole by Catechol-Mediated Dispersion Enhance Neurogenesis of Human Neural Stem Cells
Biomacromolecules, 2017, 18 (10), pp 3060–3072
DOI: 10.1021/acs.biomac.7b00568

Two-Dimensional Supramolecular Assemblies from pH-Responsive Poly(ethyl glycol)-b-poly(l-glutamic acid)-b-poly(N-octylglycine) Triblock Copolymer
Biomacromolecules, 2017, 18 (10), pp 3367–3374
DOI: 10.1021/acs.biomac.7b01014

H-Ferritin Enriches the Curcumin Uptake and Improves the Therapeutic Efficacy in Triple Negative Breast Cancer Cells
Open Access Through ACS AuthorChoice.
Biomacromolecules, 2017, 18 (10), pp 3318–3330
DOI: 10.1021/acs.biomac.7b00974

***

Journal of Agricultural and Food Chemistry

Fluxapyroxad Haptens and Antibodies for Highly Sensitive Immunoanalysis of Food Samples
J. Agric. Food Chem., 2017, 65 (42), pp 9333–9341
DOI: 10.1021/acs.jafc.7b03199

Identification and Characterization of Volatile Components Causing the Characteristic Flavor of Wagyu Beef (Japanese Black Cattle)
J. Agric. Food Chem., 2017, 65 (39), pp 8691–8695
DOI: 10.1021/acs.jafc.7b02843

Influence of Fermentation Temperature, Yeast Strain, and Grape Juice on the Aroma Chemistry and Sensory Profile of Sauvignon Blanc Wines
J. Agric. Food Chem., 2017, 65 (40), pp 8902–8912
DOI: 10.1021/acs.jafc.7b03229

Antiaflatoxigenic and Antimicrobial Activities of Schiff Bases of 2-Hydroxy-4-methoxybenzaldehyde, Cinnamaldehyde, and Similar Aldehydes
J. Agric. Food Chem., 2017, 65 (40), pp 8773–8778
DOI: 10.1021/acs.jafc.7b02576

Soluble Protein and Amino Acid Content Affects the Foam Quality of Sparkling Wine
J. Agric. Food Chem., 2017, 65 (41), pp 9110–9119
DOI: 10.1021/acs.jafc.7b02675

***

Journal of Chemical Theory and Computation

Multistate Complete-Active-Space Second-Order Perturbation Theory Based on Density Matrix Renormalization Group Reference States
Open Access Through ACS Editors’ Choice.
J. Chem. Theory Comput., 2017, 13 (10), pp 4829–4840
DOI: 10.1021/acs.jctc.7b00735

Classical Force Fields Tailored for QM Applications: Is It Really a Feasible Strategy?
J. Chem. Theory Comput., 2017, 13 (10), pp 4636–4648
DOI: 10.1021/acs.jctc.7b00777

Large-Scale Condensed Matter DFT Simulations: Performance and Capabilities of the CRYSTAL Code
J. Chem. Theory Comput., 2017, 13 (10), pp 5019–5027
DOI: 10.1021/acs.jctc.7b00687

Identification and Validation of Reaction Coordinates Describing Protein Functional Motion: Hierarchical Dynamics of T4 Lysozyme
J. Chem. Theory Comput., 2017, 13 (10), pp 5076–5088
DOI: 10.1021/acs.jctc.7b00571

Stochastic GW Calculations for Molecules
J. Chem. Theory Comput., 2017, 13 (10), pp 4997–5003
DOI: 10.1021/acs.jctc.7b00770

***

Journal of Medicinal Chemistry

Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat
J. Med. Chem., 2017, 60 (20), pp 8336–8357
DOI: 10.1021/acs.jmedchem.7b00678

Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space
J. Med. Chem., 2017, 60 (19), pp 8160–8169
DOI: 10.1021/acs.jmedchem.7b01006

Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor
J. Med. Chem., 2017, 60 (20), pp 8369–8384
DOI: 10.1021/acs.jmedchem.7b00746

Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements
Open Access Through ACS AuthorChoice.
J. Med. Chem., 2017, 60 (19), pp 8183–8191
DOI: 10.1021/acs.jmedchem.7b01071

In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery
J. Med. Chem., 2017, 60 (20), pp 8552–8564
DOI: 10.1021/acs.jmedchem.7b01075

***

Journal of Natural Products

3,5-Dimethylorsellinic Acid Derived Meroterpenoids from Penicillium chrysogenum MT-12, an Endophytic Fungus Isolated from Huperzia serrata
J. Nat. Prod., 2017, 80 (10), pp 2699–2707
DOI: 10.1021/acs.jnatprod.7b00438

Metabolites from the Plant Endophytic Fungus Aspergillus sp. CPCC 400735 and Their Anti-HIV Activities
J. Nat. Prod., 2017, 80 (10), pp 2595–2601
DOI: 10.1021/acs.jnatprod.6b00878

Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata
J. Nat. Prod., 2017, 80 (10), pp 2620–2629
DOI: 10.1021/acs.jnatprod.7b00113

Lorneic Acid Analogues from an Endophytic Actinomycete
J. Nat. Prod., 2017, 80 (10), pp 2615–2619
DOI: 10.1021/acs.jnatprod.7b00056

Sesquiterpenes from the Endophyte Glomerella cingulata
J. Nat. Prod., 2017, 80 (10), pp 2609–2614
DOI: 10.1021/acs.jnatprod.7b00054

***

The Journal of Physical Chemistry B

Thermodynamics of Hydration Water around an Antifreeze Protein: A Molecular Simulation Study
J. Phys. Chem. B, 2017, 121 (41), pp 9498–9507
DOI: 10.1021/acs.jpcb.7b05892

Roles of Chemical Functionality and Pore Curvature in the Design of Nanoporous Proton Conductors
J. Phys. Chem. B, 2017, 121 (40), pp 9429–9436
DOI: 10.1021/acs.jpcb.7b06366

Effect of a Tertiary Butyl Group on Polar Solvation Dynamics in Aqueous Solution: Femtosecond Fluorescence Spectroscopy
J. Phys. Chem. B, 2017, 121 (41), pp 9631–9638
DOI: 10.1021/acs.jpcb.7b05031

Nonexponential Kinetics of Loop Formation in Proteins and Peptides: A Signature of Rugged Free Energy Landscapes?
J. Phys. Chem. B, 2017, 121 (41), pp 9518–9525
DOI: 10.1021/acs.jpcb.7b07075

Reduced Point Charge Models of Proteins: Effect of Protein–Water Interactions in Molecular Dynamics Simulations of Ubiquitin Systems
J. Phys. Chem. B, 2017, 121 (42), pp 9771–9784
DOI: 10.1021/acs.jpcb.7b06355

***

The Journal of Physical Chemistry Letters

Protein Hydration Dynamics: Much Ado about Nothing?
J. Phys. Chem. Lett., 2017, 8 (19), pp 4878–4882
DOI: 10.1021/acs.jpclett.7b02324

Surface Traps in Colloidal Quantum Dots: A Combined Experimental and Theoretical Perspective
Open Access Through ACS AuthorChoice.
J. Phys. Chem. Lett., 2017, 8 (20), pp 5209–5215
DOI: 10.1021/acs.jpclett.7b02193

Stability and Performance of Sulfide-, Nitride-, and Phosphide-Based Electrodes for Photocatalytic Solar Water Splitting
J. Phys. Chem. Lett., 2017, 8 (20), pp 5228–5238
DOI: 10.1021/acs.jpclett.7b00772

Supervised Machine-Learning-Based Determination of Three-Dimensional Structure of Metallic Nanoparticles
J. Phys. Chem. Lett., 2017, 8 (20), pp 5091–5098
DOI: 10.1021/acs.jpclett.7b02364

Self-Assembly of Mesophases from Nanoparticles
J. Phys. Chem. Lett., 2017, 8 (20), pp 5053–5058
DOI: 10.1021/acs.jpclett.7b02237

***

Journal of Proteome Research

Optimization and Modeling of Quadrupole Orbitrap Parameters for Sensitive Analysis toward Single-Cell Proteomics
J. Proteome Res., 2017, 16 (10), pp 3711–3721
DOI: 10.1021/acs.jproteome.7b00416

Disease Association and Druggability of WD40 Repeat Proteins
J. Proteome Res., 2017, 16 (10), pp 3766–3773
DOI: 10.1021/acs.jproteome.7b00451

Comparative Proteomic and Transcriptomic Analysis of Follistatin-Induced Skeletal Muscle Hypertrophy
J. Proteome Res., 2017, 16 (10), pp 3477–3490
DOI: 10.1021/acs.jproteome.7b00069

Identification of Siglec Ligands Using a Proximity Labeling Method
J. Proteome Res., 2017, 16 (10), pp 3929–3941
DOI: 10.1021/acs.jproteome.7b00625

Comparative Proteomics Enables Identification of Nonannotated Cold Shock Proteins in E. coli
J. Proteome Res., 2017, 16 (10), pp 3722–3731
DOI: 10.1021/acs.jproteome.7b00419

***

Molecular Pharmaceutics

Crown Ethers: Novel Permeability Enhancers for Ocular Drug Delivery?
Open Access Through ACS AuthorChoice.
Mol. Pharmaceutics, 2017, 14 (10), pp 3528–3538
DOI: 10.1021/acs.molpharmaceut.7b00556

Charge Shielding Prevents Aggregation of Supercharged GFP Variants at High Protein Concentration
Mol. Pharmaceutics, 2017, 14 (10), pp 3269–3280
DOI: 10.1021/acs.molpharmaceut.7b00322

ImmunoPET Imaging of CD146 in Murine Models of Intrapulmonary Metastasis of Non-Small Cell Lung Cancer
Mol. Pharmaceutics, 2017, 14 (10), pp 3239–3247
DOI: 10.1021/acs.molpharmaceut.7b00216

Design and Solidification of Fast-Releasing Clofazimine Nanoparticles for Treatment of Cryptosporidiosis
Open Access Through ACS AuthorChoice.
Mol. Pharmaceutics, 2017, 14 (10), pp 3480–3488
DOI: 10.1021/acs.molpharmaceut.7b00521

Using Peptide Aptamer Targeted Polymers as a Model Nanomedicine for Investigating Drug Distribution in Cancer Nanotheranostics
Mol. Pharmaceutics, 2017, 14 (10), pp 3539–3549
DOI: 10.1021/acs.molpharmaceut.7b00560

If you have comments or questions for the author of this post, please e-mail: Axial@acs.org.