Discover the Most-Read Biological Chemistry Articles of November 2017

What were chemists reading in November of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each analytical chemistry ACS Publications journal in November 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great November 2017 Chemistry Research:

Analytical Chemistry | Applied Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Organic/Inorganic Chemistry | Physical Chemistry

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ACS Biomaterials Science & Engineering

Integrated Multiscale Biomaterials Experiment and Modeling
This article is part of the Multiscale Biological Materials and Systems: Integration of Experiment, Modeling, and Theory special issue.
ACS Biomater. Sci. Eng., 2017, 3 (11), pp 2628–2632
DOI: 10.1021/acsbiomaterials.7b00821

Effects of Inflammation on Multiscale Biomechanical Properties of Cartilaginous Cells and Tissues
Open access through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2017, 3 (11), pp 2644–2656
DOI: 10.1021/acsbiomaterials.6b00671

3D Bioprinting: New Directions in Articular Cartilage Tissue Engineering
ACS Biomater. Sci. Eng., 2017, 3 (11), pp 2657–2668
DOI: 10.1021/acsbiomaterials.6b00587

Mechanically and Electrically Enhanced CNT–Collagen Hydrogels As Potential Scaffolds for Engineered Cardiac Constructs
ACS Biomater. Sci. Eng., 2017, 3 (11), pp 3017–3021
DOI: 10.1021/acsbiomaterials.6b00620

Orthopedic Interface Repair Strategies Based on Native Structural and Mechanical Features of the Multiscale Enthesis
ACS Biomater. Sci. Eng., 2017, 3 (11), pp 2633–2643
DOI: 10.1021/acsbiomaterials.6b00599

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ACS Catalysis

Photocatalytic Water Splitting: Quantitative Approaches toward Photocatalyst by Design
Open Access Through ACS AuthorChoice
ACS Catal., 2017, 7 (11), pp 8006–8022
DOI: 10.1021/acscatal.7b02662

Carbon-Based Electrocatalysts for Hydrogen and Oxygen Evolution Reactions
ACS Catal., 2017, 7 (11), pp 7855–7865
DOI: 10.1021/acscatal.7b02718

Visible-Light-Driven Synthesis of 4-Alkyl/Aryl-2-Aminothiazoles Promoted by In Situ Generated Copper Photocatalyst
ACS Catal., 2017, 7 (11), pp 7941–7945
DOI: 10.1021/acscatal.7b02818

ZIF-67-Derived Nanoreactors for Controlling Product Selectivity in CO2 Hydrogenation
ACS Catal., 2017, 7 (11), pp 7509–7519
DOI: 10.1021/acscatal.7b01827

Two-Dimensional Mesoporous Carbon Doped with Fe–N Active Sites for Efficient Oxygen Reduction
ACS Catal., 2017, 7 (11), pp 7638–7646
DOI: 10.1021/acscatal.7b02101

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ACS Chemical Biology

Introducing Our Authors
ACS Chem. Biol., 2017, 12 (11), pp 2697–2698
DOI: 10.1021/acschembio.7b00955

Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches
ACS Chem. Biol., 2017, 12 (11), pp 2906–2914
DOI: 10.1021/acschembio.7b00537

Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action
ACS Chem. Biol., 2017, 12 (11), pp 2730–2736
DOI: 10.1021/acschembio.7b00708

Augmenting Influenza-Specific T Cell Memory Generation with a Natural Killer T Cell-Dependent Glycolipid–Peptide Vaccine
ACS Chem. Biol., 2017, 12 (11), pp 2898–2905
DOI: 10.1021/acschembio.7b00845

Targeted Disruption of Myc–Max Oncoprotein Complex by a Small Molecule
ACS Chem. Biol., 2017, 12 (11), pp 2715–2719
DOI: 10.1021/acschembio.7b00799

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ACS Chemical Neuroscience

Feeling Rejected? ACS Chemical Neuroscience Can Help Get Your Science to the Neuroscience Community As Quickly As Possible
ACS Chem. Neurosci., 2017, 8 (11), pp 2348–2348
DOI: 10.1021/acschemneuro.7b00380

Caring about Power Analyses
ACS Chem. Neurosci., 2017, 8 (11), pp 2352–2354
DOI: 10.1021/acschemneuro.7b003412

Embarking on a 5 Year Journey to Highlight Genetic and Rare Diseases of the Central Nervous System
ACS Chem. Neurosci., 2017, 8 (11), pp 2349–2349
DOI: 10.1021/acschemneuro.7b00401

The Medicinal Chemistry of Natural and Semisynthetic Compounds against Parkinson’s and Huntington’s Diseases
ACS Chem. Neurosci., 2017, 8 (11), pp 2356–2368
DOI: 10.1021/acschemneuro.7b00283

Future Priorities in Tackling Infections Due to Brain-Eating Amoebae
ACS Chem. Neurosci., 2017, 8 (11), pp 2355–2355
DOI: 10.1021/acschemneuro.7b00343

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ACS Infectious Diseases

Rigid Oxazole Acinetobactin Analog Blocks Siderophore Cycling in Acinetobacter baumannii
ACS Infect. Dis., 2017, 3 (11), pp 802–806
DOI: 10.1021/acsinfecdis.7b00146

Small-Molecule Potentiators for Conventional Antibiotics against Staphylococcus aureus
ACS Infect. Dis., 2017, 3 (11), pp 780–796
DOI: 10.1021/acsinfecdis.7b00084

Daptomycin Pore Formation Is Restricted by Lipid Acyl Chain Composition
ACS Infect. Dis., 2017, 3 (11), pp 797–801
DOI: 10.1021/acsinfecdis.7b00138

Reversibility of Covalent, Broad-Spectrum Serine β-Lactamase Inhibition by the Diazabicyclooctenone ETX2514
ACS Infect. Dis., 2017, 3 (11), pp 833–844
DOI: 10.1021/acsinfecdis.7b00113

Pyrazinoic Acid Inhibits Mycobacterial Coenzyme A Biosynthesis by Binding to Aspartate Decarboxylase PanD
Open access through ACS AuthorChoice
ACS Infect. Dis., 2017, 3 (11), pp 807–819
DOI: 10.1021/acsinfecdis.7b00079

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ACS Medicinal Chemistry Letters

Selective Estrogen Receptor Degraders (SERDs): A Promising Treatment to Overcome Resistance to Endocrine Therapy in ERα-Positive Breast Cancer
ACS Med. Chem. Lett., 2017, 8 (11), pp 1129–1131
DOI: 10.1021/acsmedchemlett.7b00424

Selective Inhibitors of Phosphodiesterase 4B (PDE-4B) May Provide a Better Treatment for CNS, Metabolic, Autoimmune, and Inflammatory Diseases
ACS Med. Chem. Lett., 2017, 8 (11), pp 1132–1133
DOI: 10.1021/acsmedchemlett.7b00425

Lysine-Specific Demethylase 1 (LSD1) Inhibitors as Potential Treatment for Different Types of Cancers
ACS Med. Chem. Lett., 2017, 8 (11), pp 1134–1135
DOI: 10.1021/acsmedchemlett.7b00426

Discovery of Indolinone-Based Multikinase Inhibitors as Potential Therapeutics for Idiopathic Pulmonary Fibrosis
ACS Med. Chem. Lett., 2017, 8 (11), pp 1142–1147
DOI: 10.1021/acsmedchemlett.7b00164

Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study
ACS Med. Chem. Lett., 2017, 8 (11), pp 1194–1198
DOI: 10.1021/acsmedchemlett.7b00369

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ACS Synthetic Biology

Dynamic Blue Light-Inducible T7 RNA Polymerases (Opto-T7RNAPs) for Precise Spatiotemporal Gene Expression Control
ACS Synth. Biol., 2017, 6 (11), pp 2157–2167
DOI: 10.1021/acssynbio.7b00169

Controlling Bdellovibrio bacteriovorus Gene Expression and Predation Using Synthetic Riboswitches
Open access through ACS AuthorChoice
ACS Synth. Biol., 2017, 6 (11), pp 2035–2041
DOI: 10.1021/acssynbio.7b00171

Bacterial Microcolonies in Gel Beads for High-Throughput Screening of Libraries in Synthetic Biology
ACS Synth. Biol., 2017, 6 (11), pp 1988–1995
DOI: 10.1021/acssynbio.7b00111

The Timing of Transcriptional Regulation in Synthetic Gene Circuits
ACS Synth. Biol., 2017, 6 (11), pp 1996–2002
DOI: 10.1021/acssynbio.7b00118

An Engineered Optogenetic Switch for Spatiotemporal Control of Gene Expression, Cell Differentiation, and Tissue Morphogenesis
ACS Synth. Biol., 2017, 6 (11), pp 2003–2013
DOI: 10.1021/acssynbio.7b00147

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Biochemistry

Defining Functional Structured RNA inside Living Cells
Biochemistry, 2017, 56 (44), pp 5847–5848
DOI: 10.1021/acs.biochem.7b00816

Molecules That Can Rewire the Taste System
Biochemistry, 2017, 56 (46), pp 6075–6076
DOI: 10.1021/acs.biochem.7b01061

Biological Roles of Protein Kinetic Stability
Biochemistry, 2017, 56 (47), pp 6179–6186
DOI: 10.1021/acs.biochem.7b00942

A Noncanonical Role for Yersiniabactin in Bacterial Copper Acquisition
Biochemistry, 2017, 56 (46), pp 6073–6074
DOI: 10.1021/acs.biochem.7b01003

Biosynthesis of an Opine Metallophore by Pseudomonas aeruginosa
Biochemistry, 2017, 56 (45), pp 5967–5971
DOI: 10.1021/acs.biochem.7b00804

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Bioconjugate Chemistry

Activated Microglia Targeting Dendrimer–Minocycline Conjugate as Therapeutics for Neuroinflammation
Bioconjugate Chem., 2017, 28 (11), pp 2874–2886
DOI: 10.1021/acs.bioconjchem.7b00569

Enzymatic Installation of Functional Molecules on Amyloid-Based Polymers
Bioconjugate Chem., 2017, 28 (11), pp 2687–2691
DOI: 10.1021/acs.bioconjchem.7b00479

Facile Formation of Gold-Nanoparticle-Loaded γ-Polyglutamic Acid Nanogels for Tumor Computed Tomography Imaging
Bioconjugate Chem., 2017, 28 (11), pp 2692–2697
DOI: 10.1021/acs.bioconjchem.7b00571

Improved Photoinduced Fluorogenic Alkene–Tetrazole Reaction for Protein Labeling
Bioconjugate Chem., 2017, 28 (11), pp 2859–2864
DOI: 10.1021/acs.bioconjchem.7b00562

Metal–Organic Frameworks@Polymer Composites Containing Cyanines for Near-Infrared Fluorescence Imaging and Photothermal Tumor Therapy
Bioconjugate Chem., 2017, 28 (11), pp 2784–2793
DOI: 10.1021/acs.bioconjchem.7b00508

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Biomacromolecules

Amphiphilic Peptide-Based Supramolecular, Noncytotoxic, Stimuli-Responsive Hydrogels with Antibacterial Activity
Biomacromolecules, 2017, 18 (11), pp 3621–3629
DOI: 10.1021/acs.biomac.7b01006

Organized Peptidic Nanostructures as Functional Materials
Biomacromolecules, 2017, 18 (11), pp 3469–3470
DOI: 10.1021/acs.biomac.7b01437

Supramolecular Copolymerization of Short Peptides and Polyoxometalates: toward the Fabrication of Underwater Adhesives
Biomacromolecules, 2017, 18 (11), pp 3524–3530
DOI: 10.1021/acs.biomac.7b00817

Antimicrobial Chitosan and Chitosan Derivatives: A Review of the Structure–Activity Relationship
Biomacromolecules, 2017, 18 (11), pp 3846–3868
DOI: 10.1021/acs.biomac.7b01058

Hydrogelation of a Naphthalene Diimide Appended Peptide Amphiphile and Its Application in Cell Imaging and Intracellular pH Sensing
Open access through ACS AuthorChoice
Biomacromolecules, 2017, 18 (11), pp 3630–3641
DOI: 10.1021/acs.biomac.7b01048

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Journal of Agricultural and Food Chemistry

Effectiveness of Commercial and Homemade Washing Agents in Removing Pesticide Residues on and in Apples
J. Agric. Food Chem., 2017, 65 (44), pp 9744–9752
DOI: 10.1021/acs.jafc.7b03118

An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice
Open access through ACS Editors’ Choice
J. Agric. Food Chem., 2017, 65 (43), pp 9435–9442
DOI: 10.1021/acs.jafc.7b02979

Identification of Lipid Biomarkers To Discriminate between the Different Production Systems for Asiago PDO Cheese
Open Access Through ACS AuthorChoice
J. Agric. Food Chem., 2017, 65 (45), pp 9887–9892
DOI: 10.1021/acs.jafc.7b03629

Do We No Longer Need To Worry about Dietary Cholesterol?
J. Agric. Food Chem., 2017, 65 (46), pp 9931–9933
DOI: 10.1021/acs.jafc.7b04829

Benzoyl Peroxide Detection in Real Samples and Zebrafish Imaging by a Designed Near-Infrared Fluorescent Probe
J. Agric. Food Chem., 2017, 65 (43), pp 9553–9558
DOI: 10.1021/acs.jafc.7b03598

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Journal of Chemical Theory and Computation

Cheap and Near Exact CASSCF with Large Active Spaces
Open access through ACS Editors’ Choice
J. Chem. Theory Comput., 2017, 13 (11), pp 5468–5478
DOI: 10.1021/acs.jctc.7b00900

Unifying Exchange Sensitivity in Transition-Metal Spin-State Ordering and Catalysis through Bond Valence Metrics
J. Chem. Theory Comput., 2017, 13 (11), pp 5443–5457
DOI: 10.1021/acs.jctc.7b00848

Automated Transition State Search and Its Application to Diverse Types of Organic Reactions
J. Chem. Theory Comput., 2017, 13 (11), pp 5780–5797
DOI: 10.1021/acs.jctc.7b00764

Prediction Errors of Molecular Machine Learning Models Lower than Hybrid DFT Error
J. Chem. Theory Comput., 2017, 13 (11), pp 5255–5264
DOI: 10.1021/acs.jctc.7b00577

Evaluation of the Factors Impacting the Accuracy of 13C NMR Chemical Shift Predictions using Density Functional Theory—The Advantage of Long-Range Corrected Functionals
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2017, 13 (11), pp 5798–5819
DOI: 10.1021/acs.jctc.7b00772

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Journal of Medicinal Chemistry

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)
J. Med. Chem., 2017, 60 (22), pp 9184–9204
DOI: 10.1021/acs.jmedchem.7b00941

Structure-Based Design and Discovery of New M2 Receptor Agonists
J. Med. Chem., 2017, 60 (22), pp 9239–9250
DOI: 10.1021/acs.jmedchem.7b01113

Synthesis, Pharmacology, and Molecular Docking Studies on 6-Desoxo-N-methylmorphinans as Potent μ-Opioid Receptor Agonists
Open Access Through ACS AuthorChoice
J. Med. Chem., 2017, 60 (22), pp 9407–9412
DOI: 10.1021/acs.jmedchem.7b01363

Thiazolino 2-Pyridone Amide Isosteres As Inhibitors of Chlamydia trachomatis Infectivity
J. Med. Chem., 2017, 60 (22), pp 9393–9399
DOI: 10.1021/acs.jmedchem.7b00716

Direct NMR Probing of Hydration Shells of Protein Ligand Interfaces and Its Application to Drug Design
Open Access Through ACS Editors’ Choice
J. Med. Chem., 2017, 60 (21), pp 8708–8715
DOI: 10.1021/acs.jmedchem.7b00845

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Journal of Natural Products

Houttuynoid M, an Anti-HSV Active Houttuynoid from Houttuynia cordata Featuring a Bis-houttuynin Chain Tethered to a Flavonoid Core
J. Nat. Prod., 2017, 80 (11), pp 3010–3013
DOI: 10.1021/acs.jnatprod.7b00620

Natural Products with Heteroatom-Rich Ring Systems
J. Nat. Prod., 2017, 80 (11), pp 3060–3079
DOI: 10.1021/acs.jnatprod.7b00575

Deinococcucins A–D, Aminoglycolipids from Deinococcus sp., a Gut Bacterium of the Carpenter Ant Camponotus japonicusa
J. Nat. Prod., 2017, 80 (11), pp 2910–2916
DOI: 10.1021/acs.jnatprod.7b00426

Cytotoxic Cardiac Glycoside Constituents of Vallaris glabra Leaves
J. Nat. Prod., 2017, 80 (11), pp 2987–2996
DOI: 10.1021/acs.jnatprod.7b00554

Bacilotetrins A and B, Anti-Staphylococcal Cyclic-Lipotetrapeptides from a Marine-
J. Nat. Prod., 2017, 80 (11), pp 2889–2892
DOI: 10.1021/acs.jnatprod.7b00356

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The Journal of Physical Chemistry B

Not Physical Chemistry (in the Eyes of the Journal of Physical Chemistry)
J. Phys. Chem. B, 2017, 121 (44), pp 10199–10199
DOI: 10.1021/acs.jpcb.7b09460

Virtual Issue in Honor of the 150th Birthday of Marie Curie: Highlighting Female Physical Chemists
J. Phys. Chem. B, 2017, 121 (43), pp 9983–9985
DOI: 10.1021/acs.jpcb.7b09653

The Hydrophobic Effect and the Role of Cosolvents
Open Access Through ACS Editors’ Choice
J. Phys. Chem. B, 2017, 121 (43), pp 9986–9998
DOI: 10.1021/acs.jpcb.7b06453

Free-Energy Surface Prediction by Flying Gaussian Method: Multisystem Representation
J. Phys. Chem. B, 2017, 121 (46), pp 10479–10483
DOI: 10.1021/acs.jpcb.7b09337

Ab Initio Molecular Dynamics Simulation of the Phosphate Ion in Water: Insights into Solvation Shell Structure, Dynamics, and Kosmotropic Activity
J. Phys. Chem. B, 2017, 121 (46), pp 10519–10529
DOI: 10.1021/acs.jpcb.7b06091

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The Journal of Physical Chemistry Letters

Size-Dependent Level Alignment between Rutile and Anatase TiO2 Nanoparticles: Implications for Photocatalysis
J. Phys. Chem. Lett., 2017, 8 (22), pp 5593–5598
DOI: 10.1021/acs.jpclett.7b02474

Transfer of Inorganic-Capped Nanocrystals into Aqueous Media
J. Phys. Chem. Lett., 2017, 8 (22), pp 5573–5578
DOI: 10.1021/acs.jpclett.7b02319

Probing the OH Stretch in Different Local Environments in Liquid Water
J. Phys. Chem. Lett., 2017, 8 (22), pp 5487–5491
DOI: 10.1021/acs.jpclett.7b02060

Direct Mapping of Band Positions in Doped and Undoped Hematite during Photoelectrochemical Water SplittingJ. Phys. Chem. Lett., 2017, 8 (22), pp 5579–5586

DOI: 10.1021/acs.jpclett.7b02548

Biological Molecules-Governed Plasmonic Nanoparticle Dimers with Tailored Optical Behaviors
J. Phys. Chem. Lett., 2017, 8 (22), pp 5633–5642
DOI: 10.1021/acs.jpclett.7b01781

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Journal of Proteome Research

Evaluation of FASP, SP3, and iST Protocols for Proteomic Sample Preparation in the Low Microgram Range
J. Proteome Res., 2017, 16 (11), pp 4060–4072
DOI: 10.1021/acs.jproteome.7b00433

Experimental Design in Clinical ‘Omics Biomarker Discovery
Open access through ACS AuthorChoice
J. Proteome Res., 2017, 16 (11), pp 3954–3960
DOI: 10.1021/acs.jproteome.7b00418

Innovations in Publishing: Prepublication of Manuscripts on Preprint Servers
J. Proteome Res., 2017, 16 (11), pp 3953–3953
DOI: 10.1021/acs.jproteome.7b00674

Sensitive and Accurate Quantitation of Phosphopeptides Using TMT Isobaric Labeling Technique
J. Proteome Res., 2017, 16 (11), pp 4244–4252
DOI: 10.1021/acs.jproteome.7b00610

Unrestricted Mass Spectrometric Data Analysis for Identification, Localization, and Quantification of Oxidative Protein Modifications
J. Proteome Res., 2017, 16 (11), pp 3978–3988
DOI: 10.1021/acs.jproteome.7b00330

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Molecular Pharmaceutics

Multidrug, Anti-HIV Amorphous Solid Dispersions: Nature and Mechanisms of Impacts of Drugs on Each Other’s Solution Concentrations
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2017, 14 (11), pp 3617–3627
DOI: 10.1021/acs.molpharmaceut.7b00203

Cleavable Multifunctional Targeting Mixed Micelles with Sequential pH-Triggered TAT Peptide Activation for Improved Antihepatocellular Carcinoma Efficacy
Mol. Pharmaceutics, 2017, 14 (11), pp 3644–3659
DOI: 10.1021/acs.molpharmaceut.7b00404

Reduction-sensitive Paclitaxel Prodrug Self-assembled Nanoparticles with Tetrandrine Effectively Promote Synergistic Therapy Against Drug-sensitive and Multidrug-resistant Breast Cancer
Mol. Pharmaceutics, 2017, 14 (11), pp 3628–3635
DOI: 10.1021/acs.molpharmaceut.7b00381

Lymphoma Immunochemotherapy: Targeted Delivery of Doxorubicin via a Dual Functional Nanocarrier
Mol. Pharmaceutics, 2017, 14 (11), pp 3888–3895
DOI: 10.1021/acs.molpharmaceut.7b00606

Receptor-Mediated Attachment and Uptake of Hyaluronan Conjugates by Breast Cancer Cells
Mol. Pharmaceutics, 2017, 14 (11), pp 3968–3977
DOI: 10.1021/acs.molpharmaceut.7b00636

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