Discover the Most-Read Biological Chemistry Articles of December 2017

What were chemists reading in December of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each biological chemistry ACS Publications journal in December 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great December 2017 Chemistry Research:

Analytical Chemistry | Applied ChemistryMaterials Science & Engineering | Multidisciplinary Chemistry | Organic/Inorganic Chemistry | Physical Chemistry

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ACS Biomaterials Science & Engineering

Methods To Assess Shear-Thinning Hydrogels for Application As Injectable Biomaterials
Open access through Editors’ Choice
ACS Biomater. Sci. Eng., 2017, 3 (12), pp 3146–3160
DOI: 10.1021/acsbiomaterials.7b00734

Dual Channel Activatable Cyanine Dye for Mitochondrial Imaging and Mitochondria-Targeted Cancer Theranostics
ACS Biomater. Sci. Eng., 2017, 3 (12), pp 3596–3606
DOI: 10.1021/acsbiomaterials.7b00480

Turning Expanded Poly(tetrafluoroethylene) Membranes into Potential Skin Wound Dressings by Grafting a Bioinert Epoxylated PEGMA Copolymer
ACS Biomater. Sci. Eng., 2017, 3 (12), pp 3338–3350
DOI: 10.1021/acsbiomaterials.7b00732

Injectable, Self-Healing Chimeric Catechol-Fe(III) Hydrogel for Localized Combination Cancer Therapy
ACS Biomater. Sci. Eng., 2017, 3 (12), pp 3404–3413
DOI: 10.1021/acsbiomaterials.7b00741

Influence of Hydroxyl Groups on the Cell Viability of Polyhydroxyalkanoate (PHA) Scaffolds for Tissue Engineering
Open access through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2017, 3 (12), pp 3064–3075
DOI: 10.1021/acsbiomaterials.6b00279

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ACS Catalysis

Tuning Mixed Nickel Iron Phosphosulfide Nanosheet Electrocatalysts for Enhanced Hydrogen and Oxygen Evolution
Open access through ACS AuthorChoice
ACS Catal., 2017, 7 (12), pp 8549–8557
DOI: 10.1021/acscatal.7b02575

Highly Selective Conversion of Carbon Dioxide to Lower Olefins
ACS Catal., 2017, 7 (12), pp 8544–8548
DOI: 10.1021/acscatal.7b03251

Metal/Porous Carbon Composites for Heterogeneous Catalysis: Old Catalysts with Improved Performance Promoted by N-Doping
ACS Catal., 2017, 7 (12), pp 8090–8112
DOI: 10.1021/acscatal.7b02335

An Efficient and Selective Nickel-Catalyzed Direct N-Alkylation of Anilines with Alcohols
ACS Catal., 2017, 7 (12), pp 8152–8158
DOI: 10.1021/acscatal.7b02817

Radical Trifluoromethylative Dearomatization of Indoles and Furans with CO2
ACS Catal., 2017, 7 (12), pp 8324–8330
DOI: 10.1021/acscatal.7b02533

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ACS Chemical Biology

Taxation on Innovation
ACS Chem. Biol., 2017, 12 (12), pp 2915–2915
DOI: 10.1021/acschembio.7b01044

Coculture of Marine Invertebrate-Associated Bacteria and Interdisciplinary Technologies Enable Biosynthesis and Discovery of a New Antibiotic, Keyicin
ACS Chem. Biol., 2017, 12 (12), pp 3093–3102
DOI: 10.1021/acschembio.7b00688

Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation
ACS Chem. Biol., 2017, 12 (12), pp 3126–3133
DOI: 10.1021/acschembio.7b00885

Insights into Interactions of Mycobacteria with the Host Innate Immune System from a Novel Array of Synthetic Mycobacterial Glycans
Open access through ACS AuthorChoice
ACS Chem. Biol., 2017, 12 (12), pp 2990–3002
DOI: 10.1021/acschembio.7b00797

Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily
ACS Chem. Biol., 2017, 12 (12), pp 3113–3125
DOI: 10.1021/acschembio.7b00334

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ACS Chemical Neuroscience

Understanding the Inflammatory Tissue Reaction to Brain Implants To Improve Neurochemical Sensing Performance
ACS Chem. Neurosci., 2017, 8 (12), pp 2578–2582
DOI: 10.1021/acschemneuro.7b00403

A Crash Course in Calcium Channels
ACS Chem. Neurosci., 2017, 8 (12), pp 2583–2585
DOI: 10.1021/acschemneuro.7b00415

Genetic and Rare Disease of the CNS. Part I: Fatal Familial Insomnia (FFI)
ACS Chem. Neurosci., 2017, 8 (12), pp 2570–2572
DOI: 10.1021/acschemneuro.7b00463

Brain-Eating Amoebae: Silver Nanoparticle Conjugation Enhanced Efficacy of Anti-Amoebic Drugs against Naegleria fowleri
ACS Chem. Neurosci., 2017, 8 (12), pp 2626–2630
DOI: 10.1021/acschemneuro.7b00430

Comparison of α-Synuclein Fibril Inhibition by Four Different Amyloid Inhibitors
ACS Chem. Neurosci., 2017, 8 (12), pp 2722–2733
DOI: 10.1021/acschemneuro.7b00261

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ACS Infectious Diseases

Exploiting the Sensitivity of Nutrient Transporter Deletion Strains in Discovery of Natural Product Antimetabolites
Open access through Editors’ Choice
ACS Infect. Dis., 2017, 3 (12), pp 955–965
DOI: 10.1021/acsinfecdis.7b00149

Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB
Open access through ACS AuthorChoice
ACS Infect. Dis., 2017, 3 (12), pp 898–916
DOI: 10.1021/acsinfecdis.7b00112

Plasma Levels of Complement Factor I and C4b Peptides Are Associated with HIV Suppression
Open access through ACS AuthorChoice
ACS Infect. Dis., 2017, 3 (12), pp 880–885
DOI: 10.1021/acsinfecdis.7b00042

Polymyxin B3–Tobramycin Hybrids with Pseudomonas aeruginosa-Selective Antibacterial Activity and Strong Potentiation of Rifampicin, Minocycline, and Vancomycin
ACS Infect. Dis., 2017, 3 (12), pp 941–954
DOI: 10.1021/acsinfecdis.7b00145

Clinical Variants of New Delhi Metallo-β-Lactamase Are Evolving To Overcome Zinc Scarcity
ACS Infect. Dis., 2017, 3 (12), pp 927–940
DOI: 10.1021/acsinfecdis.7b00128

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ACS Medicinal Chemistry Letters

Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain
ACS Med. Chem. Lett., 2017, 8 (12), pp 1309–1313
DOI: 10.1021/acsmedchemlett.7b00396

Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions
ACS Med. Chem. Lett., 2017, 8 (12), pp 1224–1229
DOI: 10.1021/acsmedchemlett.7b00239

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors
ACS Med. Chem. Lett., 2017, 8 (12), pp 1298–1303
DOI: 10.1021/acsmedchemlett.7b00389

Novel Naphthalimide Aminothiazoles as Potential Multitargeting Antimicrobial Agents
ACS Med. Chem. Lett., 2017, 8 (12), pp 1331–1335
DOI: 10.1021/acsmedchemlett.7b00452

Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol
Open access through ACS AuthorChoice
ACS Med. Chem. Lett., 2017, 8 (12), pp 1304–1308
DOI: 10.1021/acsmedchemlett.7b00391

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ACS Synthetic Biology

Blue Light Switchable Bacterial Adhesion as a Key Step toward the Design of Biofilms
ACS Synth. Biol., 2017, 6 (12), pp 2170–2174
DOI: 10.1021/acssynbio.7b00197

A Cell-Free Biosensor for Detecting Quorum Sensing Molecules in P. aeruginosa-Infected Respiratory Samples
ACS Synth. Biol., 2017, 6 (12), pp 2293–2301
DOI: 10.1021/acssynbio.7b00219

Combining CRISPR and CRISPRi Systems for Metabolic Engineering of E. coli and 1,4-BDO Biosynthesis
ACS Synth. Biol., 2017, 6 (12), pp 2350–2361
DOI: 10.1021/acssynbio.7b00251

Genetic Constructor: An Online DNA Design Platform
Open access through ACS AuthorChoice
ACS Synth. Biol., 2017, 6 (12), pp 2362–2365
DOI: 10.1021/acssynbio.7b00236

Rapid and Scalable Preparation of Bacterial Lysates for Cell-Free Gene Expression
ACS Synth. Biol., 2017, 6 (12), pp 2198–2208
DOI: 10.1021/acssynbio.7b00253

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Biochemistry

Novel Biology and Druggable Targets via Chemoproteomics
Biochemistry, 2017, 56 (50), pp 6515–6516
DOI: 10.1021/acs.biochem.7b01167

Reactive Dopamine Leads to Triple Trouble in Nigral Neurons
Biochemistry, 2017, 56 (49), pp 6409–6410
DOI: 10.1021/acs.biochem.7b01057

Tuning the Flexibility of Glycine-Serine Linkers To Allow Rational Design of Multidomain Proteins
Open access through ACS AuthorChoice
Biochemistry, 2017, 56 (50), pp 6565–6574
DOI: 10.1021/acs.biochem.7b00902

Finding a Silver Bullet in a Stack of Proteins
Biochemistry, 2017, 56 (51), pp 6627–6628
DOI: 10.1021/acs.biochem.7b01177

Ragtime Regulation: Mechanism of TORC1 Activation in Nutrient Sensing
Biochemistry, 2017, 56 (49), pp 6411–6412
DOI: 10.1021/acs.biochem.7b01120

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Bioconjugate Chemistry

Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates
Bioconjugate Chem., 2017, 28 (12), pp 2921–2931
DOI: 10.1021/acs.bioconjchem.7b00476

Programmable Peptide-Cross-Linked Nucleic Acid Nanocapsules as a Modular Platform for Enzyme Specific Cargo Release
Bioconjugate Chem., 2017, 28 (12), pp 2910–2914
DOI: 10.1021/acs.bioconjchem.7b00629

Cell Penetrating Polymers Containing Guanidinium Trigger Apoptosis in Human Hepatocellular Carcinoma Cells unless Conjugated to a Targeting N-Acetyl-Galactosamine Block
Bioconjugate Chem., 2017, 28 (12), pp 2985–2997
DOI: 10.1021/acs.bioconjchem.7b00598

Photocontrolled Release of Doxorubicin Conjugated through a Thioacetal Photocage in Folate-Targeted Nanodelivery Systems
Bioconjugate Chem., 2017, 28 (12), pp 3016–3028
DOI: 10.1021/acs.bioconjchem.7b00614

Pretargeted PET Imaging Using a Bioorthogonal 18F-Labeled trans-Cyclooctene in an Ovarian Carcinoma Model
Bioconjugate Chem., 2017, 28 (12), pp 2915–2920
DOI: 10.1021/acs.bioconjchem.7b00635

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Biomacromolecules

Stereoselective Stabilization of Polymeric Vitamin E Conjugate Micelles
Biomacromolecules, 2017, 18 (12), pp 4349–4356
DOI: 10.1021/acs.biomac.7b01409

Injectable Thermosensitive Polypeptide-Based CDDP-Complexed Hydrogel for Improving Localized Antitumor Efficacy
Biomacromolecules, 2017, 18 (12), pp 4341–4348
DOI: 10.1021/acs.biomac.7b01374

Star Polymers Reduce Islet Amyloid Polypeptide Toxicity via Accelerated Amyloid Aggregation
Open access through ACS Editors’ Choice
Biomacromolecules, 2017, 18 (12), pp 4249–4260
DOI: 10.1021/acs.biomac.7b01301

Systemic mRNA Delivery to the Lungs by Functional Polyester-based Carriers
Biomacromolecules, 2017, 18 (12), pp 4307–4315
DOI: 10.1021/acs.biomac.7b01356

Doxorubicin-Loaded Unimolecular Micelle-Stabilized Gold Nanoparticles as a Theranostic Nanoplatform for Tumor-Targeted Chemotherapy and Computed Tomography Imaging
Biomacromolecules, 2017, 18 (12), pp 3869–3880
DOI: 10.1021/acs.biomac.7b00810

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Journal of Agricultural and Food Chemistry

Discovery of a New Fungicide Candidate through Lead Optimization of Pyrimidinamine Derivatives and Its Activity against Cucumber Downy Mildew
J. Agric. Food Chem., 2017, 65 (49), pp 10829–10835
DOI: 10.1021/acs.jafc.7b03898

Preparation of Lignin/Sodium Dodecyl Sulfate Composite Nanoparticles and Their Application in Pickering Emulsion Template-Based Microencapsulation
J. Agric. Food Chem., 2017, 65 (50), pp 11011–11019
DOI: 10.1021/acs.jafc.7b03784

Ellagitannins from Strawberries with Different Degrees of Polymerization Showed Different Metabolism through Gastrointestinal Tract of Rats
J. Agric. Food Chem., 2017, 65 (49), pp 10738–10748
DOI: 10.1021/acs.jafc.7b04120

Chemistry, Antimicrobial Mechanisms, and Antibiotic Activities of Cinnamaldehyde against Pathogenic Bacteria in Animal Feeds and Human Foods
J. Agric. Food Chem., 2017, 65 (48), pp 10406–10423
DOI: 10.1021/acs.jafc.7b04344

Bioactive Compounds of Edible Purple Laver Porphyra sp. (Nori)
J. Agric. Food Chem., 2017, 65 (49), pp 10685–10692
DOI: 10.1021/acs.jafc.7b04688

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Journal of Chemical Theory and Computation

Accurate Excited-State Geometries: A CASPT2 and Coupled-Cluster Reference Database for Small Molecules
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2017, 13 (12), pp 6237–6252
DOI: 10.1021/acs.jctc.7b00921

Efficient Construction of Free Energy Profiles of Breathing Metal–Organic Frameworks Using Advanced Molecular Dynamics Simulations
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2017, 13 (12), pp 5861–5873
DOI: 10.1021/acs.jctc.7b01014

Constant-pH Molecular Dynamics Simulations for Large Biomolecular Systems
J. Chem. Theory Comput., 2017, 13 (12), pp 5933–5944
DOI: 10.1021/acs.jctc.7b00875

Nonadiabatic Dynamics of Cycloparaphenylenes with TD-DFTB Surface Hopping
J. Chem. Theory Comput., 2017, 13 (12), pp 5846–5860
DOI: 10.1021/acs.jctc.7b01000

Alchemical Free Energy Calculations for Nucleotide Mutations in Protein–DNA Complexes
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2017, 13 (12), pp 6275–6289
DOI: 10.1021/acs.jctc.7b00849

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Journal of Medicinal Chemistry

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)
Open access through Editors’ Choice
J. Med. Chem., 2017, 60 (24), pp 9960–9973
DOI: 10.1021/acs.jmedchem.7b00907

Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma
J. Med. Chem., 2017, 60 (24), pp 10071–10091
DOI: 10.1021/acs.jmedchem.7b01290

Design of Novel 3-Pyrimidinylazaindole CDK2/9 Inhibitors with Potent In Vitro and In Vivo Antitumor Efficacy in a Triple-Negative Breast Cancer Model
J. Med. Chem., 2017, 60 (23), pp 9470–9489
DOI: 10.1021/acs.jmedchem.7b00663

Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity
J. Med. Chem., 2017, 60 (24), pp 10188–10204
DOI: 10.1021/acs.jmedchem.7b01447

Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That Induces AMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer
J. Med. Chem., 2017, 60 (24), pp 9990–10012
DOI: 10.1021/acs.jmedchem.7b00275

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Journal of Natural Products

Bibenzyl-Based Meroterpenoid Enantiomers from the Chinese Liverwort Radula sumatrana
J. Nat. Prod., 2017, 80 (12), pp 3143–3150
DOI: 10.1021/acs.jnatprod.7b00394

Sesqui- and Diterpenoids from the Radix of Curcuma aromatica
J. Nat. Prod., 2017, 80 (12), pp 3093–3102
DOI: 10.1021/acs.jnatprod.6b01100

Cephanolides A–J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis
J. Nat. Prod., 2017, 80 (12), pp 3159–3166
DOI: 10.1021/acs.jnatprod.7b00412

Securamine Derivatives from the Arctic Bryozoan Securiflustra securifrons
J. Nat. Prod., 2017, 80 (12), pp 3276–3283
DOI: 10.1021/acs.jnatprod.7b00703

Pimentelamines A–C, Indole Alkaloids Isolated from the Leaves of the Australian Tree Flindersia pimenteliana
J. Nat. Prod., 2017, 80 (12), pp 3211–3217
DOI: 10.1021/acs.jnatprod.7b00587

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The Journal of Physical Chemistry B

Computation of Hemagglutinin Free Energy Difference by the Confinement Method
Open access through ACS AuthorChoice
J. Phys. Chem. B, 2017, 121 (50), pp 11292–11303
DOI: 10.1021/acs.jpcb.7b09699

Pitch and Handedness of the Cholesteric Order in Films of a Chiral Alternating Fluorene Copolymer
Open access through ACS AuthorChoice
J. Phys. Chem. B, 2017, 121 (51), pp 11520–11527
DOI: 10.1021/acs.jpcb.7b10236

Unwinding Induced Melting of Double-Stranded DNA Studied by Free Energy Simulations
Open access through ACS Editors’ Choice
J. Phys. Chem. B, 2017, 121 (49), pp 11019–11030
DOI: 10.1021/acs.jpcb.7b07701

Ab Initio Simulations of Water Dynamics in Aqueous TMAO Solutions: Temperature and Concentration Effects
J. Phys. Chem. B, 2017, 121 (49), pp 11189–11197
DOI: 10.1021/acs.jpcb.7b09989

Understanding the Inhibiting Effect of Small-Molecule Hydrogen Bond Donors on the Solubility of Cellulose in Tetrabutylammonium Acetate/DMSO
Open access through ACS AuthorChoice
J. Phys. Chem. B, 2017, 121 (50), pp 11241–11248
DOI: 10.1021/acs.jpcb.7b08501

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The Journal of Physical Chemistry Letters

The Mayonnaise Effect
J. Phys. Chem. Lett., 2017, 8 (24), pp 6189–6192
DOI: 10.1021/acs.jpclett.7b03207

Exciton–Exciton Annihilation Is Coherently Suppressed in H-Aggregates, but Not in J-Aggregates
Open access through ACS AuthorChoice
J. Phys. Chem. Lett., 2017, 8 (24), pp 6113–6117
DOI: 10.1021/acs.jpclett.7b02745

Bright Tail States in Blue-Emitting Ultrasmall Perovskite Quantum Dots
J. Phys. Chem. Lett., 2017, 8 (24), pp 6002–6008
DOI: 10.1021/acs.jpclett.7b02786

How Strong Is the Hydrogen Bond in Hybrid Perovskites?
Open access through ACS AuthorChoice
J. Phys. Chem. Lett., 2017, 8 (24), pp 6154–6159
DOI: 10.1021/acs.jpclett.7b03106

Controllable Synthesis of Two-Dimensional Ruddlesden–Popper-Type Perovskite Heterostructures
J. Phys. Chem. Lett., 2017, 8 (24), pp 6211–6219
DOI: 10.1021/acs.jpclett.7b02843

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Journal of Proteome Research

Progress and Future Direction of Chromosome-Centric Human Proteome Project
This article is part of the Chromosome-Centric Human Proteome Project 2017 special issue.
J. Proteome Res., 2017, 16 (12), pp 4253–4258
DOI: 10.1021/acs.jproteome.7b00734

Proteomics Standards Initiative: Fifteen Years of Progress and Future Work
This article is part of the Chromosome-Centric Human Proteome Project 2017 special issue.
J. Proteome Res., 2017, 16 (12), pp 4288–4298
DOI: 10.1021/acs.jproteome.7b00370

Quality Assessments of Long-Term Quantitative Proteomic Analysis of Breast Cancer Xenograft Tissues
This article is part of the Chromosome-Centric Human Proteome Project 2017 special issue.
J. Proteome Res., 2017, 16 (12), pp 4523–4530
DOI: 10.1021/acs.jproteome.7b00362

The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays
This article is part of the Chromosome-Centric Human Proteome Project 2017 special issue.
J. Proteome Res., 2017, 16 (12), pp 4299–4310
DOI: 10.1021/acs.jproteome.7b00467

Synaptosomal Proteome of the Orbitofrontal Cortex from Schizophrenia Patients Using Quantitative Label-Free and iTRAQ-Based Shotgun Proteomics
This article is part of the Chromosome-Centric Human Proteome Project 2017 special issue.
J. Proteome Res., 2017, 16 (12), pp 4481–4494
DOI: 10.1021/acs.jproteome.7b00422

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Molecular Pharmaceutics

Comparison of Deep Learning With Multiple Machine Learning Methods and Metrics Using Diverse Drug Discovery Data Sets
Mol. Pharmaceutics, 2017, 14 (12), pp 4462–4475
DOI: 10.1021/acs.molpharmaceut.7b00578

Industry–Academic Collaboration in Oral Biopharmaceutics: The European IMI OrBiTo Project
This article is part of the Industry-Academic Collaboration in Oral Biopharmaceutics: The European IMI OrBiTo Project special issue.
Mol. Pharmaceutics, 2017, 14 (12), pp 4129–4131
DOI: 10.1021/acs.molpharmaceut.7b00940

Influence of Physiological Gastrointestinal Surfactant Ratio on the Equilibrium Solubility of BCS Class II Drugs Investigated Using a Four Component Mixture Design
Open access through ACS AuthorChoice
This article is part of the Industry-Academic Collaboration in Oral Biopharmaceutics: The European IMI OrBiTo Project special issue.
Mol. Pharmaceutics, 2017, 14 (12), pp 4132–4144
DOI: 10.1021/acs.molpharmaceut.7b00354

Impact of the US FDA “Biopharmaceutics Classification System” (BCS) Guidance on Global Drug Development
Mol. Pharmaceutics, 2017, 14 (12), pp 4334–4338
DOI: 10.1021/acs.molpharmaceut.7b00687

Model-Based Analysis of Biopharmaceutic Experiments To Improve Mechanistic Oral Absorption Modeling: An Integrated in Vitro in Vivo Extrapolation Perspective Using Ketoconazole as a Model Drug
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2017, 14 (12), pp 4305–4320
DOI: 10.1021/acs.molpharmaceut.7b00406

 

 

 

 

 

 

 

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