Discover the Most-Read Organic/Inorganic Chemistry Articles of December 2017

What were chemists reading in December of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each organic and inorganic chemistry ACS Publications journal in December 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great December 2017 Chemistry Research:

Analytical Chemistry | Applied Chemistry | Biological Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Physical Chemistry

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ACS Catalysis

Tuning Mixed Nickel Iron Phosphosulfide Nanosheet Electrocatalysts for Enhanced Hydrogen and Oxygen Evolution
Open access through ACS AuthorChoice
ACS Catal., 2017, 7 (12), pp 8549–8557
DOI: 10.1021/acscatal.7b02575

Highly Selective Conversion of Carbon Dioxide to Lower Olefins
ACS Catal., 2017, 7 (12), pp 8544–8548
DOI: 10.1021/acscatal.7b03251

Metal/Porous Carbon Composites for Heterogeneous Catalysis: Old Catalysts with Improved Performance Promoted by N-Doping
ACS Catal., 2017, 7 (12), pp 8090–8112
DOI: 10.1021/acscatal.7b02335

An Efficient and Selective Nickel-Catalyzed Direct N-Alkylation of Anilines with Alcohols
ACS Catal., 2017, 7 (12), pp 8152–8158
DOI: 10.1021/acscatal.7b02817

Radical Trifluoromethylative Dearomatization of Indoles and Furans with CO2
ACS Catal., 2017, 7 (12), pp 8324–8330
DOI: 10.1021/acscatal.7b02533

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ACS Combinatorial Science

High-Throughput Chemical Probing of Full-Length Protein–Protein Interactions
ACS Comb. Sci., 2017, 19 (12), pp 763–769
DOI: 10.1021/acscombsci.7b00128

Synthesis of 2-Alkoxy/Thioalkoxy Benzo[d]imidazoles and 2-Thione Benzo[d]imidazoles via a Phase-Based, Chemoselective Reaction
ACS Comb. Sci., 2017, 19 (12), pp 738–747
DOI: 10.1021/acscombsci.7b00106

Microwave-Facilitated SPOT-Synthesis of Antibacterial Dipeptoids
ACS Comb. Sci., 2017, 19 (12), pp 715–737
DOI: 10.1021/acscombsci.7b00096

Stereoselective Synthesis of Benzo[e][1,4]oxazino[4,3-a][1,4]diazepine-6,12-diones with Two Diversity Positions
ACS Comb. Sci., 2017, 19 (12), pp 770–774
DOI: 10.1021/acscombsci.7b00134

Efficient Synthesis of 1,9-Substituted Benzo[h][1,6]naphthyridin-2(1H)-ones and Evaluation of their Plasmodium falciparum Gametocytocidal Activities
ACS Comb. Sci., 2017, 19 (12), pp 748–754
DOI: 10.1021/acscombsci.7b00119

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ACS Medicinal Chemistry Letters

Discovery of APD371: Identification of a Highly Potent and Selective CB2 Agonist for the Treatment of Chronic Pain
ACS Med. Chem. Lett., 2017, 8 (12), pp 1309–1313
DOI: 10.1021/acsmedchemlett.7b00396

Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions
ACS Med. Chem. Lett., 2017, 8 (12), pp 1224–1229
DOI: 10.1021/acsmedchemlett.7b00239

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors
ACS Med. Chem. Lett., 2017, 8 (12), pp 1298–1303
DOI: 10.1021/acsmedchemlett.7b00389

Novel Naphthalimide Aminothiazoles as Potential Multitargeting Antimicrobial Agents
ACS Med. Chem. Lett., 2017, 8 (12), pp 1331–1335
DOI: 10.1021/acsmedchemlett.7b00452

Long-Lasting and Fast-Acting in Vivo Efficacious Antiplasmodial Azepanylcarbazole Amino Alcohol
Open access through ACS AuthorChoice
ACS Med. Chem. Lett., 2017, 8 (12), pp 1304–1308
DOI: 10.1021/acsmedchemlett.7b00391

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Bioconjugate Chemistry

Latent Warheads for Targeted Cancer Therapy: Design and Synthesis of pro-Pyrrolobenzodiazepines and Conjugates
Bioconjugate Chem., 2017, 28 (12), pp 2921–2931
DOI: 10.1021/acs.bioconjchem.7b00476

Programmable Peptide-Cross-Linked Nucleic Acid Nanocapsules as a Modular Platform for Enzyme Specific Cargo Release
Bioconjugate Chem., 2017, 28 (12), pp 2910–2914
DOI: 10.1021/acs.bioconjchem.7b00629

Cell Penetrating Polymers Containing Guanidinium Trigger Apoptosis in Human Hepatocellular Carcinoma Cells unless Conjugated to a Targeting N-Acetyl-Galactosamine Block
Bioconjugate Chem., 2017, 28 (12), pp 2985–2997
DOI: 10.1021/acs.bioconjchem.7b00598

Photocontrolled Release of Doxorubicin Conjugated through a Thioacetal Photocage in Folate-Targeted Nanodelivery Systems
Bioconjugate Chem., 2017, 28 (12), pp 3016–3028
DOI: 10.1021/acs.bioconjchem.7b00614

Pretargeted PET Imaging Using a Bioorthogonal 18F-Labeled trans-Cyclooctene in an Ovarian Carcinoma Model
Bioconjugate Chem., 2017, 28 (12), pp 2915–2920
DOI: 10.1021/acs.bioconjchem.7b00635

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Inorganic Chemistry

The Promise of Self-Assembled 3D Supramolecular Coordination Complexes for Biomedical Applications
Inorg. Chem., 2017, 56 (24), pp 14715–14729
DOI: 10.1021/acs.inorgchem.7b02599

From Positive to Negative Zero-Field Splitting in a Series of Strongly Magnetically Anisotropic Mononuclear Metal Complexes
Open access through ACS Editors’ Choice
Inorg. Chem., 2017, 56 (24), pp 14809–14822
DOI: 10.1021/acs.inorgchem.7b01861

Mixed Valency as a Strategy for Achieving Charge Delocalization in Semiconducting and Conducting Framework Materials
Inorg. Chem., 2017, 56 (23), pp 14373–14382
DOI: 10.1021/acs.inorgchem.7b02090

Microporous Cobalt(II)–Organic Framework with Open O-Donor Sites for Effective C2H2 Storage and C2H2/CO2 Separation at Room Temperature
Inorg. Chem., 2017, 56 (24), pp 14767–14770
DOI: 10.1021/acs.inorgchem.7b02764

Probing Spin Crossover in a Solution by Paramagnetic NMR Spectroscopy
Inorg. Chem., 2017, 56 (24), pp 14759–14762
DOI: 10.1021/acs.inorgchem.7b02649

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Journal of Medicinal Chemistry

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)
Open access through Editors’ Choice
J. Med. Chem., 2017, 60 (24), pp 9960–9973
DOI: 10.1021/acs.jmedchem.7b00907

Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma
J. Med. Chem., 2017, 60 (24), pp 10071–10091
DOI: 10.1021/acs.jmedchem.7b01290

Design of Novel 3-Pyrimidinylazaindole CDK2/9 Inhibitors with Potent In Vitro and In Vivo Antitumor Efficacy in a Triple-Negative Breast Cancer Model
J. Med. Chem., 2017, 60 (23), pp 9470–9489
DOI: 10.1021/acs.jmedchem.7b00663

Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity
J. Med. Chem., 2017, 60 (24), pp 10188–10204
DOI: 10.1021/acs.jmedchem.7b01447

Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That Induces AMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer
J. Med. Chem., 2017, 60 (24), pp 9990–10012
DOI: 10.1021/acs.jmedchem.7b00275

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Journal of Natural Products

Bibenzyl-Based Meroterpenoid Enantiomers from the Chinese Liverwort Radula sumatrana
J. Nat. Prod., 2017, 80 (12), pp 3143–3150
DOI: 10.1021/acs.jnatprod.7b00394

Sesqui- and Diterpenoids from the Radix of Curcuma aromatica
J. Nat. Prod., 2017, 80 (12), pp 3093–3102
DOI: 10.1021/acs.jnatprod.6b01100

Cephanolides A–J, Cephalotane-Type Diterpenoids from Cephalotaxus sinensis
J. Nat. Prod., 2017, 80 (12), pp 3159–3166
DOI: 10.1021/acs.jnatprod.7b00412

Securamine Derivatives from the Arctic Bryozoan Securiflustra securifrons
J. Nat. Prod., 2017, 80 (12), pp 3276–3283
DOI: 10.1021/acs.jnatprod.7b00703

Pimentelamines A–C, Indole Alkaloids Isolated from the Leaves of the Australian Tree Flindersia pimenteliana
J. Nat. Prod., 2017, 80 (12), pp 3211–3217
DOI: 10.1021/acs.jnatprod.7b00587

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The Journal of Organic Chemistry

Cyanopivaloyl Ester in the Automated Solid-Phase Synthesis of Oligorhamnans
Open access through ACS Editors’ Choice
J. Org. Chem., 2017, 82 (24), pp 12992–13002
DOI: 10.1021/acs.joc.7b02511

Regioselective C–H Bond Alkynylation of Carbonyl Compounds through Ir(III) Catalysis
J. Org. Chem., 2017, 82 (24), pp 13003–13011
DOI: 10.1021/acs.joc.7b01489

Base-Mediated Three-Component Tandem Reactions for the Synthesis of Multisubstituted Pyrimidines
J. Org. Chem., 2017, 82 (24), pp 13609–13616
DOI: 10.1021/acs.joc.7b02113

Synthesis of 3-Fluoropyridines via Photoredox-Mediated Coupling of α,α-Difluoro-β-iodoketones with Silyl Enol Ethers
Open access through ACS AuthorChoice
J. Org. Chem., 2017, 82 (24), pp 12967–12974
DOI: 10.1021/acs.joc.7b02467

Visible Light Organic Photoredox-Catalyzed C–H Alkoxylation of Imidazopyridine with Alcohol
J. Org. Chem., 2017, 82 (24), pp 13722–13727
DOI: 10.1021/acs.joc.7b02582

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Molecular Pharmaceutics

Comparison of Deep Learning With Multiple Machine Learning Methods and Metrics Using Diverse Drug Discovery Data Sets
Mol. Pharmaceutics, 2017, 14 (12), pp 4462–4475
DOI: 10.1021/acs.molpharmaceut.7b00578

Industry–Academic Collaboration in Oral Biopharmaceutics: The European IMI OrBiTo Project
This article is part of the Industry-Academic Collaboration in Oral Biopharmaceutics: The European IMI OrBiTo Project special issue.
Mol. Pharmaceutics, 2017, 14 (12), pp 4129–4131
DOI: 10.1021/acs.molpharmaceut.7b00940

Influence of Physiological Gastrointestinal Surfactant Ratio on the Equilibrium Solubility of BCS Class II Drugs Investigated Using a Four Component Mixture Design
Open access through ACS AuthorChoice
This article is part of the Industry-Academic Collaboration in Oral Biopharmaceutics: The European IMI OrBiTo Project special issue.
Mol. Pharmaceutics, 2017, 14 (12), pp 4132–4144
DOI: 10.1021/acs.molpharmaceut.7b00354

Impact of the US FDA “Biopharmaceutics Classification System” (BCS) Guidance on Global Drug Development
Mol. Pharmaceutics, 2017, 14 (12), pp 4334–4338
DOI: 10.1021/acs.molpharmaceut.7b00687

Model-Based Analysis of Biopharmaceutic Experiments To Improve Mechanistic Oral Absorption Modeling: An Integrated in Vitro in Vivo Extrapolation Perspective Using Ketoconazole as a Model Drug
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2017, 14 (12), pp 4305–4320
DOI: 10.1021/acs.molpharmaceut.7b00406

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Organic Letters

Iodobenzene-Catalyzed Ortho-Dearomatization and Aromatization-Triggered Rearrangement of 2-Allylanilines: Construction of Indolin-3-ylmethanols with High Diastereoselectivities
Org. Lett., 2017, 19 (24), pp 6478–6481
DOI: 10.1021/acs.orglett.7b02986

Highly Diastereoselective Cationic Cyclization Reactions Convert a Common Monocyclic Enone to Bicyclic Precursors for the Synthesis of Retigeranic Acids A and B
Org. Lett., 2017, 19 (24), pp 6686–6687
DOI: 10.1021/acs.orglett.7b03412

Iron(III)-Catalyzed Ortho-Preferred Radical Nucleophilic Alkylation of Electron-Deficient Arenes
Org. Lett., 2017, 19 (24), pp 6538–6541
DOI: 10.1021/acs.orglett.7b03244

Catalytic Enantioselective Synthesis of (−)-Podophyllotoxin
Org. Lett., 2017, 19 (24), pp 6530–6533
DOI: 10.1021/acs.orglett.7b03236

Total Synthesis of Propolisbenzofuran B
Org. Lett., 2017, 19 (24), pp 6466–6469
DOI: 10.1021/acs.orglett.7b02732

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Organic Process Research & Development

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2017, 21 (12), pp 1873–1883
DOI: 10.1021/acs.oprd.7b00371

Sodium Hypochlorite Pentahydrate Crystals (NaOCl·5H2O): A Convenient and Environmentally Benign Oxidant for Organic Synthesis
Open access through ACS AuthorChoice
Org. Process Res. Dev., 2017, 21 (12), pp 1925–1937
DOI: 10.1021/acs.oprd.7b00288

Regulatory Highlights
Org. Process Res. Dev., 2017, 21 (12), pp 1884–1888
DOI: 10.1021/acs.oprd.7b0037

Investigation of the Stereoselective Synthesis of the Indane Dimer PH46A, a New Potential Anti-inflammatory Agent
Org. Process Res. Dev., 2017, 21 (12), pp 1972–1979
DOI: 10.1021/acs.oprd.7b002582

Continuous-Flow Preparation of γ-Butyrolactone Scaffolds from Renewable Fumaric and Itaconic Acids under Photosensitized Conditions
Org. Process Res. Dev., 2017, 21 (12), pp 2012–2017
DOI: 10.1021/acs.oprd.7b00314

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Organometallics

Iron Pincer Complexes Incorporating Bipyridine: A Strategy for Stabilization of Reactive Species
Organometallics, 2017, 36 (24), pp 4928–4935
DOI: 10.1021/acs.organomet.7b00772

Cobalt Complexes Supported by cis-Macrocyclic Diphosphines: Synthesis, Reactivity, and Activity toward Coupling Carbon Dioxide and Ethylene
Organometallics, 2017, 36 (24), pp 4834–4843
DOI: 10.1021/acs.organomet.7b00734

N-Heterocycle-Ligated Borocations as Highly Tunable Carbon Lewis Acids
Organometallics, 2017, 36 (24), pp 4952–4960
DOI: 10.1021/acs.organomet.7b00779

Elusive Phosphine Copper(I) Boryl Complexes: Synthesis, Structures, and Reactivity
Organometallics, 2017, 36 (24), pp 4687–4690
DOI: 10.1021/acs.organomet.7b00775

Trends in Metallophilic Bonding in Pd–Zn and Pd–Cu Complexes
Organometallics, 2017, 36 (24), pp 4854–4863
DOI: 10.1021/acs.organomet.7b00748