Most Read Articles of 2017: Biological Chemistry

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention over the past year.

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Read more of 2017’s most-read articles: Analytical | Applied | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical

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ACS Biomaterials Science & Engineering

Metal-Chelation-Assisted Deposition of Polydopamine on Human Hair: A Ready-to-Use Eumelanin-Based Hair Dyeing Methodology
ACS Biomater. Sci. Eng., 2017, 3 (4), pp 628–636
DOI: 10.1021/acsbiomaterials.7b00031

Surface Analysis of Nanocomplexes by X-ray Photoelectron Spectroscopy (XPS)
Open access through Editors’ Choice
ACS Biomater. Sci. Eng., 2017, 3 (6), pp 882–889
DOI: 10.1021/acsbiomaterials.7b00040

Preparation of Biodegradable Cationic Polycarbonates and Hydrogels through the Direct Polymerization of Quaternized Cyclic Carbonates
Open access through Editors’ Choice
ACS Biomater. Sci. Eng., 2017, 3 (8), pp 1567–1575
DOI: 10.1021/acsbiomaterials.7b00335

Bioconjugation of Gold Nanobipyramids for SERS Detection and Targeted Photothermal Therapy in Breast Cancer
Open access through Editors’ Choice
ACS Biomater. Sci. Eng., 2017, 3 (4), pp 608–618
DOI: 10.1021/acsbiomaterials.7b00021

3D Printing of a Double Network Hydrogel with a Compression Strength and Elastic Modulus Greater than those of Cartilage
ACS Biomater. Sci. Eng., 2017, 3 (5), pp 863–869
DOI: 10.1021/acsbiomaterials.7b00094

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ACS Catalysis

Catalysis by Supported Single Metal Atoms
ACS Catal., 2017, 7 (1), pp 34–59
DOI: 10.1021/acscatal.6b01534

Rational Design of High-Performance Phosphine Sulfonate Nickel Catalysts for Ethylene Polymerization and Copolymerization with Polar Monomers
Open access through ACS AuthorChoice
ACS Catal., 2017, 7 (2), pp 1308–1312
DOI: 10.1021/acscatal.6b03394

Superlative Scientific Writing
ACS Catal., 2017, 7 (3), pp 2218–2219
DOI: 10.1021/acscatal.7b00566

Kinetic Modeling of the Nickel-Catalyzed Esterification of Amides
Open access through Editors’ Choice
ACS Catal., 2017, 7 (7), pp 4381–4385
DOI: 10.1021/acscatal.7b01444

Visible-Light-Mediated Anti-Markovnikov Hydration of Olefins
Open access through Editors’ Choice
ACS Catal., 2017, 7 (2), pp 1432–1437
DOI: 10.1021/acscatal.6b03388

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ACS Chemical Biology

Proteolysis-Targeting Chimeras: Induced Protein Degradation as a Therapeutic Strategy
ACS Chem. Biol., 2017, 12 (4), pp 892–898
DOI: 10.1021/acschembio.6b01068

Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation
ACS Chem. Biol., 2017, 12 (10), pp 2570–2578
DOI: 10.1021/acschembio.7b00485

Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases
Open access through Editors’ Choice
ACS Chem. Biol., 2017, 12 (3), pp 852–861
DOI: 10.1021/acschembio.6b01052

Enzyme That Makes You Cry–Crystal Structure of Lachrymatory Factor Synthase from Allium cepa
ACS Chem. Biol., 2017, 12 (9), pp 2296–2304
DOI: 10.1021/acschembio.7b00336

Ionic Strength Sensing in Living Cells
Open access through ACS AuthorChoice
ACS Chem. Biol., 2017, 12 (10), pp 2510–2514
DOI: 10.1021/acschembio.7b00348

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ACS Chemical Neuroscience

Hitchhiker’s Guide to Voltammetry: Acute and Chronic Electrodes for in Vivo Fast-Scan Cyclic Voltammetry
Open access through Editors’ Choice
ACS Chem. Neurosci., 2017, 8 (2), pp 221–234
DOI: 10.1021/acschemneuro.6b00393

Chronic Traumatic Encephalopathy (CTE): A Brief Historical Overview and Recent Focus on NFL Players
ACS Chem. Neurosci., 2017, 8 (8), pp 1629–1631
DOI: 10.1021/acschemneuro.7b00291

Call for Papers: DARK Classics in Chemical Neuroscience
ACS Chem. Neurosci., 2017, 8 (9), pp 1812–1812
DOI: 10.1021/acschemneuro.7b00306

Why Is Research on Amyloid-β Failing to Give New Drugs for Alzheimer’s Disease?
ACS Chem. Neurosci., 2017, 8 (7), pp 1435–1437
DOI: 10.1021/acschemneuro.7b00188

The Striosome and Matrix Compartments of the Striatum: A Path through the Labyrinth from Neurochemistry toward Function
Open access through ACS AuthorChoice
ACS Chem. Neurosci., 2017, 8 (2), pp 235–242
DOI: 10.1021/acschemneuro.6b00333

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ACS Infectious Diseases

Human Milk Oligosaccharides Exhibit Antimicrobial and Antibiofilm Properties against Group B Streptococcus
Open access through Editors’ Choice
ACS Infect. Dis., 2017, 3 (8), pp 595–605
DOI: 10.1021/acsinfecdis.7b00064

Hydrophilic Phage-Mimicking Membrane Active Antimicrobials Reveal Nanostructure-Dependent Activity and Selectivity
Open access through Editors’ Choice
ACS Infect. Dis., 2017, 3 (9), pp 676–687
DOI: 10.1021/acsinfecdis.7b00076

Discovery of a Novel Nitric Oxide Binding Protein and Nitric-Oxide-Responsive Signaling Pathway in Pseudomonas aeruginosa
Open access through Editors’ Choice
ACS Infect. Dis., 2017, 3 (6), pp 454–461
DOI: 10.1021/acsinfecdis.7b00027

Rational Design of Single-Chain Polymeric Nanoparticles That Kill Planktonic and Biofilm Bacteria
ACS Infect. Dis., 2017, 3 (3), pp 237–248
DOI: 10.1021/acsinfecdis.6b00203

Ribosome Rescue Inhibitors Kill Actively Growing and Nonreplicating Persister Mycobacterium tuberculosis Cells
ACS Infect. Dis., 2017, 3 (9), pp 634–644
DOI: 10.1021/acsinfecdis.7b00028

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ACS Medicinal Chemistry Letters

INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology
Open access through Editors’ Choice
ACS Med. Chem. Lett., 2017, 8 (5), pp 486–491
DOI: 10.1021/acsmedchemlett.6b00391

Medicinal Chemistry: Where Are All the Women?
ACS Med. Chem. Lett., 2017, 8 (9), pp 900–902
DOI: 10.1021/acsmedchemlett.7b00321

Practical High-Throughput Experimentation for Chemists
Open access through ACS AuthorChoice
ACS Med. Chem. Lett., 2017, 8 (6), pp 601–607
DOI: 10.1021/acsmedchemlett.7b00165

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin
Open access through Editors’ Choice
ACS Med. Chem. Lett., 2017, 8 (3), pp 321–326
DOI: 10.1021/acsmedchemlett.6b00491

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton’s Tyrosine Kinase with Improved Druglike Properties
Open access through Editors’ Choice
ACS Med. Chem. Lett., 2017, 8 (6), pp 608–613
DOI: 10.1021/acsmedchemlett.7b00103

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ACS Synthetic Biology

A Straightforward Approach for 3D Bacterial Printing
Open access through ACS AuthorChoice
ACS Synth. Biol., 2017, 6 (7), pp 1124–1130
DOI: 10.1021/acssynbio.6b00395

Programmable DNA-Guided Artificial Restriction Enzymes
ACS Synth. Biol., 2017, 6 (5), pp 752–757
DOI: 10.1021/acssynbio.6b00324

Application of an Acyl-CoA Ligase from Streptomyces aizunensis for Lactam Biosynthesis
Open access through Editors’ Choice
ACS Synth. Biol., 2017, 6 (5), pp 884–890
DOI: 10.1021/acssynbio.6b00372

Extracellular Self-Assembly of Functional and Tunable Protein Conjugates from Bacillus subtilis
Open access through ACS AuthorChoice
ACS Synth. Biol., 2017, 6 (6), pp 957–967
DOI: 10.1021/acssynbio.6b00292

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Biochemistry

Residue-Specific Peptide Modification: A Chemist’s Guide
Biochemistry, 2017, 56 (30), pp 3863–3873
DOI: 10.1021/acs.biochem.7b00536

It Is Chemistry but Not Your Grandfather’s Chemistry
Biochemistry, 2017, 56 (1), pp 1–2
DOI: 10.1021/acs.biochem.6b01262

The Cation−π Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification
Open access through Editors’ Choice
Biochemistry, 2017, 56 (11), pp 1585–1595
DOI: 10.1021/acs.biochem.7b00056

Identification of Microprotein–Protein Interactions via APEX Tagging
Open access through Editors’ Choice
Biochemistry, 2017, 56 (26), pp 3299–3306
DOI: 10.1021/acs.biochem.7b00265

Structure–Energy Relationships of Halogen Bonds in Proteins
Open access through Editors’ Choice
Biochemistry, 2017, 56 (22), pp 2794–2802
DOI: 10.1021/acs.biochem.7b00022

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Bioconjugate Chemistry

In Vivo Delivery of CRISPR/Cas9 for Therapeutic Gene Editing: Progress and Challenges
Bioconjugate Chem., 2017, 28 (4), pp 880–884
DOI: 10.1021/acs.bioconjchem.7b00057

Site-Specific Dual Functionalization of Cysteine Residue in Peptides and Proteins with 2-Azidoacrylates
Open access through Editors’ Choice
Bioconjugate Chem., 2017, 28 (4), pp 897–902
DOI: 10.1021/acs.bioconjchem.7b00024

89Zr-Immuno-Positron Emission Tomography in Oncology: State-of-the-Art 89Zr Radiochemistry
Open access through ACS AuthorChoice
Bioconjugate Chem., 2017, 28 (9), pp 2211–2223
DOI: 10.1021/acs.bioconjchem.7b00325

Versatile Site-Selective Protein Reaction Guided by WW Domain–Peptide Motif Interaction
Open access through Editors’ Choice
Bioconjugate Chem., 2017, 28 (8), pp 2199–2205
DOI: 10.1021/acs.bioconjchem.7b00334

Biointerfacing and Applications of Cell Membrane-Coated Nanoparticles
This article is part of the Interfacing Inorganic Nanoparticles with Biology special issue.
Bioconjugate Chem., 2017, 28 (1), pp 23–32
DOI: 10.1021/acs.bioconjchem.6b00569

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Biomacromolecules

Hydrogels for Therapeutic Delivery: Current Developments and Future Directions
Open access through ACS AuthorChoice
Biomacromolecules, 2017, 18 (2), pp 316–330
DOI: 10.1021/acs.biomac.6b01604

Stimuli-Responsive Polymersomes for Biomedical Applications
Biomacromolecules, 2017, 18 (3), pp 649–673
DOI: 10.1021/acs.biomac.6b01704

Recent Developments in the Synthesis of Biomacromolecules and their Conjugates by Single Electron Transfer–Living Radical Polymerization
Open access through Editors’ Choice
Biomacromolecules, 2017, 18 (4), pp 1039–1063
DOI: 10.1021/acs.biomac.7b00197

Degradable Adhesives for Surgery and Tissue Engineering
Open access through ACS AuthorChoice
Biomacromolecules, 2017, 18 (10), pp 3009–3039
DOI: 10.1021/acs.biomac.7b00969

Injectable and 3D Bioprinted Polysaccharide Hydrogels: From Cartilage to Osteochondral Tissue Engineering
Biomacromolecules, 2017, 18 (1), pp 1–26
DOI: 10.1021/acs.biomac.6b01619

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Journal of Agricultural and Food Chemistry

Control of Maillard Reactions in Foods: Strategies and Chemical Mechanisms
Open access through ACS AuthorChoice
J. Agric. Food Chem., 2017, 65 (23), pp 4537–4552
DOI: 10.1021/acs.jafc.7b00882

Rare Sugar Syrup Containing d-Allulose but Not High-Fructose Corn Syrup Maintains Glucose Tolerance and Insulin Sensitivity Partly via Hepatic Glucokinase Translocation in Wistar Rats
Open access through Editors’ Choice
J. Agric. Food Chem., 2017, 65 (13), pp 2888–2894
DOI: 10.1021/acs.jafc.6b05627

Development of a QuEChERS-Based Method for the Simultaneous Determination of Acidic Pesticides, Their Esters, and Conjugates Following Alkaline Hydrolysis
Open access through Editors’ Choice
J. Agric. Food Chem., 2017, 65 (6), pp 1296–1305
DOI: 10.1021/acs.jafc.6b05407

Novel trans-Ferulic Acid Derivatives Containing a Chalcone Moiety as Potential Activator for Plant Resistance Induction
Open access through Editors’ Choice
J. Agric. Food Chem., 2017, 65 (22), pp 4367–4377
DOI: 10.1021/acs.jafc.7b00958

An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice
Open access through Editors’ Choice
J. Agric. Food Chem., 2017, 65 (43), pp 9435–9442
DOI: 10.1021/acs.jafc.7b02979

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Journal of Chemical Theory and Computation

An Ab Initio Exciton Model Including Charge-Transfer Excited States
Open access through Editors’ Choice
J. Chem. Theory Comput., 2017, 13 (8), pp 3493–3504
DOI: 10.1021/acs.jctc.7b00171

A Robust and Accurate Tight-Binding Quantum Chemical Method for Structures, Vibrational Frequencies, and Noncovalent Interactions of Large Molecular Systems Parametrized for All spd-Block Elements (Z = 1–86)
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2017, 13 (5), pp 1989–2009
DOI: 10.1021/acs.jctc.7b00118

Machine Learning Force Field Parameters from Ab Initio Data
J. Chem. Theory Comput., 2017, 13 (9), pp 4492–4503
DOI: 10.1021/acs.jctc.7b00521

Psi4 1.1: An Open-Source Electronic Structure Program Emphasizing Automation, Advanced Libraries, and Interoperability
J. Chem. Theory Comput., 2017, 13 (7), pp 3185–3197
DOI: 10.1021/acs.jctc.7b00174

Cheap and Near Exact CASSCF with Large Active Spaces
Open access through Editors’ Choice
J. Chem. Theory Comput., 2017, 13 (11), pp 5468–5478
DOI: 10.1021/acs.jctc.7b00900

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Journal of Medicinal Chemistry

The Essential Medicinal Chemistry of Curcumin
Open access through Editors’ Choice
J. Med. Chem., 2017, 60 (5), pp 1620–1637
DOI: 10.1021/acs.jmedchem.6b00975

Synthetic Approaches to the New Drugs Approved During 2015
Open access through Editors’ Choice
J. Med. Chem., 2017, 60 (15), pp 6480–6515
DOI: 10.1021/acs.jmedchem.7b00010

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases
J. Med. Chem., 2017, 60 (4), pp 1247–1261
DOI: 10.1021/acs.jmedchem.6b01751

A Versatile Method to Determine the Cellular Bioavailability of Small-Molecule Inhibitors
Open access through Editors’ Choice
J. Med. Chem., 2017, 60 (1), pp 157–169
DOI: 10.1021/acs.jmedchem.6b00923

How Big Is Too Big for Cell Permeability?
J. Med. Chem., 2017, 60 (5), pp 1662–1664
DOI: 10.1021/acs.jmedchem.7b00237

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Journal of Natural Products

Fungal Identification Using Molecular Tools: A Primer for the Natural Products Research Community
Open access through ACS AuthorChoice
J. Nat. Prod., 2017, 80 (3), pp 756–770
DOI: 10.1021/acs.jnatprod.6b01085

The Bengamides: A Mini-Review of Natural Sources, Analogues, Biological Properties, Biosynthetic Origins, and Future Prospects
Open access through Editors’ Choice
J. Nat. Prod., 2017, 80 (3), pp 740–755
DOI: 10.1021/acs.jnatprod.6b00970

The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture
J. Nat. Prod., 2017, 80 (4), pp 1150–1160
DOI: 10.1021/acs.jnatprod.7b00133

Bioinspired Indole Prenylation Reactions in Water
Open access through Editors’ Choice
J. Nat. Prod., 2017, 80 (8), pp 2371–2378
DOI: 10.1021/acs.jnatprod.7b00464

Antineoplastic Agents. 603. Quinstatins: Exceptional Cancer Cell Growth Inhibitors
Open access through Editors’ Choice
J. Nat. Prod., 2017, 80 (3), pp 692–698
DOI: 10.1021/acs.jnatprod.6b01006

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The Journal of Physical Chemistry B

The Hydrophobic Effect and the Role of Cosolvents
Open access through Editors’ Choice
J. Phys. Chem. B, 2017, 121 (43), pp 9986–9998
DOI: 10.1021/acs.jpcb.7b06453

Crowding in Cellular Environments at an Atomistic Level from Computer Simulations
Open access through Editors’ Choice
J. Phys. Chem. B, 2017, 121 (34), pp 8009–8025
DOI: 10.1021/acs.jpcb.7b03570

Beyond the Hofmeister Series: Ion-Specific Effects on Proteins and Their Biological Functions
J. Phys. Chem. B, 2017, 121 (9), pp 1997–2014
DOI: 10.1021/acs.jpcb.6b10797

Evolutionary Covariance Combined with Molecular Dynamics Predicts a Framework for Allostery in the MutS DNA Mismatch Repair Protein
Open access through Editors’ Choice
J. Phys. Chem. B, 2017, 121 (9), pp 2049–2061
DOI: 10.1021/acs.jpcb.6b11976

Virtual Issue in Honor of the 150th Birthday of Marie Curie: Highlighting Female Physical Chemists
J. Phys. Chem. B, 2017, 121 (43), pp 9983–9985
DOI: 10.1021/acs.jpcb.7b09653

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The Journal of Physical Chemistry Letters

Cs2InAgCl6: A New Lead-Free Halide Double Perovskite with Direct Band Gap
J. Phys. Chem. Lett., 2017, 8 (4), pp 772–778
DOI: 10.1021/acs.jpclett.6b02682

Charge Carrier Trapping at Surface Defects of Perovskite Solar Cell Absorbers: A First-Principles Study
Open access through Editors’ Choice
J. Phys. Chem. Lett., 2017, 8 (4), pp 742–746
DOI: 10.1021/acs.jpclett.7b00055

Photoresponse of CsPbBr3 and Cs4PbBr6 Perovskite Single Crystals
J. Phys. Chem. Lett., 2017, 8 (3), pp 565–570
DOI: 10.1021/acs.jpclett.6b02763

High-Quality (CH3NH3)3Bi2I9 Film-Based Solar Cells: Pushing Efficiency up to 1.64%
Open access through Editors’ Choice
J. Phys. Chem. Lett., 2017, 8 (17), pp 4300–4307
DOI: 10.1021/acs.jpclett.7b01952

Hydrogen-Mediated Electron Doping of Gold Clusters As Revealed by In Situ X-ray and UV–vis Absorption Spectroscopy
Open access through Editors’ Choice
J. Phys. Chem. Lett., 2017, 8 (11), pp 2368–2372
DOI: 10.1021/acs.jpclett.7b00722

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Journal of Proteome Research

Discovery of Novel Antimicrobial Peptides from Varanus komodoensis (Komodo Dragon) by Large-Scale Analyses and De-Novo-Assisted Sequencing Using Electron-Transfer Dissociation Mass Spectrometry
J. Proteome Res., 2017, 16 (4), pp 1470–1482
DOI: 10.1021/acs.jproteome.6b00857

MHC-I Ligand Discovery Using Targeted Database Searches of Mass Spectrometry Data: Implications for T-Cell Immunotherapies
Open access through Editors’ Choice
J. Proteome Res., 2017, 16 (4), pp 1806–1816
DOI: 10.1021/acs.jproteome.6b00971

Global Post-Translational Modification Discovery
Open access through ACS AuthorChoice
J. Proteome Res., 2017, 16 (4), pp 1383–1390
DOI: 10.1021/acs.jproteome.6b00034

Assessment of Label-Free Quantification in Discovery Proteomics and Impact of Technological Factors and Natural Variability of Protein Abundance
Open access through ACS AuthorChoice
J. Proteome Res., 2017, 16 (4), pp 1410–1424
DOI: 10.1021/acs.jproteome.6b00645

Quantitative Analysis of Human Red Blood Cell Proteome
Open access through ACS AuthorChoice
J. Proteome Res., 2017, 16 (8), pp 2752–2761
DOI: 10.1021/acs.jproteome.7b00025

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Molecular Pharmaceutics

Lipid–Drug Conjugate for Enhancing Drug Delivery
This article is part of the Bioconjugate Therapeutics special issue.
Mol. Pharmaceutics, 2017, 14 (5), pp 1325–1338
DOI: 10.1021/acs.molpharmaceut.6b01027

Tracking Antibody Distribution with Near-Infrared Fluorescent Dyes: Impact of Dye Structure and Degree of Labeling on Plasma Clearance
Open access through Editors’ Choice
Mol. Pharmaceutics, 2017, 14 (5), pp 1623–1633
DOI: 10.1021/acs.molpharmaceut.6b01091

Encapsulation of Ibuprofen in CD-MOF and Related Bioavailability Studies
Mol. Pharmaceutics, 2017, 14 (5), pp 1831–1839
DOI: 10.1021/acs.molpharmaceut.7b00168

Clinically Relevant Multidrug Transporters Are Regulated by microRNAs along the Human Intestine
Open access through Editors’ Choice
Mol. Pharmaceutics, 2017, 14 (7), pp 2245–2253
DOI: 10.1021/acs.molpharmaceut.7b00076

Biocompatible Injectable Hydrogel with Potent Wound Healing and Antibacterial Properties
Mol. Pharmaceutics, 2017, 14 (4), pp 1218–1230
DOI: 10.1021/acs.molpharmaceut.6b01104

 

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