Most-Read Articles of 2017: Organic and Inorganic Chemistry

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention over the past year.

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Read more of 2017’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Physical

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ACS Catalysis

Catalysis by Supported Single Metal Atoms
ACS Catal., 2017, 7 (1), pp 34–59
DOI: 10.1021/acscatal.6b01534

Rational Design of High-Performance Phosphine Sulfonate Nickel Catalysts for Ethylene Polymerization and Copolymerization with Polar Monomers
Open access through ACS AuthorChoice
ACS Catal., 2017, 7 (2), pp 1308–1312
DOI: 10.1021/acscatal.6b03394

Superlative Scientific Writing
ACS Catal., 2017, 7 (3), pp 2218–2219
DOI: 10.1021/acscatal.7b00566

Kinetic Modeling of the Nickel-Catalyzed Esterification of Amides
Open access through Editors’ Choice
ACS Catal., 2017, 7 (7), pp 4381–4385
DOI: 10.1021/acscatal.7b01444

Visible-Light-Mediated Anti-Markovnikov Hydration of Olefins
Open access through Editors’ Choice
ACS Catal., 2017, 7 (2), pp 1432–1437
DOI: 10.1021/acscatal.6b03388

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ACS Combinatorial Science

An Integrated Microfluidic Processor for DNA-Encoded Combinatorial Library Functional Screening
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ACS Comb. Sci., 2017, 19 (3), pp 181–192
DOI: 10.1021/acscombsci.6b00192

Poisson Statistics of Combinatorial Library Sampling Predict False Discovery Rates of Screening
ACS Comb. Sci., 2017, 19 (8), pp 524–532
DOI: 10.1021/acscombsci.7b00061

Rationally Designed Peptides and Peptidomimetics as Inhibitors of Amyloid-β (Aβ) Aggregation: Potential Therapeutics of Alzheimer’s Disease
ACS Comb. Sci., 2017, 19 (2), pp 55–80
DOI: 10.1021/acscombsci.6b00116

Automated Phase Mapping with AgileFD and its Application to Light Absorber Discovery in the V–Mn–Nb Oxide System
Open access through Editors’ Choice
ACS Comb. Sci., 2017, 19 (1), pp 37–46
DOI: 10.1021/acscombsci.6b00153

Technical Advances in Medicinal Chemistry
ACS Comb. Sci., 2017, 19 (5), pp 277–278
DOI: 10.1021/acscombsci.7b00053

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ACS Medicinal Chemistry Letters

INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology
Open access through Editors’ Choice
ACS Med. Chem. Lett., 2017, 8 (5), pp 486–491
DOI: 10.1021/acsmedchemlett.6b00391

Medicinal Chemistry: Where Are All the Women?
ACS Med. Chem. Lett., 2017, 8 (9), pp 900–902
DOI: 10.1021/acsmedchemlett.7b00321

Practical High-Throughput Experimentation for Chemists
Open access through ACS AuthorChoice
ACS Med. Chem. Lett., 2017, 8 (6), pp 601–607
DOI: 10.1021/acsmedchemlett.7b00165

Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin
Open access through Editors’ Choice
ACS Med. Chem. Lett., 2017, 8 (3), pp 321–326
DOI: 10.1021/acsmedchemlett.6b00491

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton’s Tyrosine Kinase with Improved Druglike Properties
Open access through Editors’ Choice
ACS Med. Chem. Lett., 2017, 8 (6), pp 608–613
DOI: 10.1021/acsmedchemlett.7b00103

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Bioconjugate Chemistry

In Vivo Delivery of CRISPR/Cas9 for Therapeutic Gene Editing: Progress and Challenges
Bioconjugate Chem., 2017, 28 (4), pp 880–884
DOI: 10.1021/acs.bioconjchem.7b00057

Site-Specific Dual Functionalization of Cysteine Residue in Peptides and Proteins with 2-Azidoacrylates
Open access through Editors’ Choice
Bioconjugate Chem., 2017, 28 (4), pp 897–902
DOI: 10.1021/acs.bioconjchem.7b00024

89Zr-Immuno-Positron Emission Tomography in Oncology: State-of-the-Art 89Zr Radiochemistry
Open access through ACS AuthorChoice
Bioconjugate Chem., 2017, 28 (9), pp 2211–2223
DOI: 10.1021/acs.bioconjchem.7b00325

Versatile Site-Selective Protein Reaction Guided by WW Domain–Peptide Motif Interaction
Open access through Editors’ Choice
Bioconjugate Chem., 2017, 28 (8), pp 2199–2205
DOI: 10.1021/acs.bioconjchem.7b00334

Biointerfacing and Applications of Cell Membrane-Coated Nanoparticles
This article is part of the Interfacing Inorganic Nanoparticles with Biology special issue.
Bioconjugate Chem., 2017, 28 (1), pp 23–32
DOI: 10.1021/acs.bioconjchem.6b00569

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Inorganic Chemistry

Metal–Metal Bonds: From Fundamentals to Applications
Inorg. Chem., 2017, 56 (14), pp 7577–7581
DOI: 10.1021/acs.inorgchem.7b01330

Tris(pentafluorophenyl)borane and Beyond: Modern Advances in Borylation Chemistry
Open access through ACS AuthorChoice
Inorg. Chem., 2017, 56 (15), pp 8627–8643
DOI: 10.1021/acs.inorgchem.6b02911

Luminescent Cyclometalated Gold(III) Alkyl Complexes: Photophysical and Photochemical Properties
Open access through Editors’ Choice
Inorg. Chem., 2017, 56 (9), pp 5046–5059
DOI: 10.1021/acs.inorgchem.7b00180

The Promise of Self-Assembled 3D Supramolecular Coordination Complexes for Biomedical Applications
Inorg. Chem., 2017, 56 (24), pp 14715–14729
DOI: 10.1021/acs.inorgchem.7b02599

From Positive to Negative Zero-Field Splitting in a Series of Strongly Magnetically Anisotropic Mononuclear Metal Complexes
Open access through Editors’ Choice
Inorg. Chem., 2017, 56 (24), pp 14809–14822
DOI: 10.1021/acs.inorgchem.7b01861

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Journal of Medicinal Chemistry

The Essential Medicinal Chemistry of Curcumin
Open access through Editors’ Choice
J. Med. Chem., 2017, 60 (5), pp 1620–1637
DOI: 10.1021/acs.jmedchem.6b00975

Synthetic Approaches to the New Drugs Approved During 2015
Open access through Editors’ Choice
J. Med. Chem., 2017, 60 (15), pp 6480–6515
DOI: 10.1021/acs.jmedchem.7b00010

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases
J. Med. Chem., 2017, 60 (4), pp 1247–1261
DOI: 10.1021/acs.jmedchem.6b01751

A Versatile Method to Determine the Cellular Bioavailability of Small-Molecule Inhibitors
Open access through Editors’ Choice
J. Med. Chem., 2017, 60 (1), pp 157–169
DOI: 10.1021/acs.jmedchem.6b00923

How Big Is Too Big for Cell Permeability?
J. Med. Chem., 2017, 60 (5), pp 1662–1664
DOI: 10.1021/acs.jmedchem.7b00237

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Journal of Natural Products

Fungal Identification Using Molecular Tools: A Primer for the Natural Products Research Community
Open access through ACS AuthorChoice
J. Nat. Prod., 2017, 80 (3), pp 756–770
DOI: 10.1021/acs.jnatprod.6b01085

The Bengamides: A Mini-Review of Natural Sources, Analogues, Biological Properties, Biosynthetic Origins, and Future Prospects
Open access through Editors’ Choice
J. Nat. Prod., 2017, 80 (3), pp 740–755
DOI: 10.1021/acs.jnatprod.6b00970

The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture
J. Nat. Prod., 2017, 80 (4), pp 1150–1160
DOI: 10.1021/acs.jnatprod.7b00133

Bioinspired Indole Prenylation Reactions in Water
Open access through Editors’ Choice
J. Nat. Prod., 2017, 80 (8), pp 2371–2378
DOI: 10.1021/acs.jnatprod.7b00464

Antineoplastic Agents. 603. Quinstatins: Exceptional Cancer Cell Growth Inhibitors
Open access through Editors’ Choice
J. Nat. Prod., 2017, 80 (3), pp 692–698
DOI: 10.1021/acs.jnatprod.6b01006

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The Journal of Organic Chemistry

Removal of Triphenylphosphine Oxide by Precipitation with Zinc Chloride in Polar Solvents
Open access through Editors’ Choice
J. Org. Chem., 2017, 82 (19), pp 9931–9936
DOI: 10.1021/acs.joc.7b00459

Natural Products and Their Mimics as Targets of Opportunity for Discovery
Open access through Editors’ Choice
J. Org. Chem., 2017, 82 (20), pp 10757–10794
DOI: 10.1021/acs.joc.7b01368

The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry–Biology Interface
Open access through Editors’ Choice
J. Org. Chem., 2017, 82 (23), pp 11961–11980
DOI: 10.1021/acs.joc.7b02088

Chlorophyll-Catalyzed Visible-Light-Mediated Synthesis of Tetrahydroquinolines from N,N-Dimethylanilines and Maleimides
Open access through Editors’ Choice
J. Org. Chem., 2017, 82 (4), pp 1888–1894
DOI: 10.1021/acs.joc.6b03034

Aliphatic C–H Bond Iodination by a N-Iodoamide and Isolation of an Elusive N-Amidyl Radical
Open access through Editors’ Choice
J. Org. Chem., 2017, 82 (14), pp 7093–7100
DOI: 10.1021/acs.joc.7b00557

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Molecular Pharmaceutics

Lipid–Drug Conjugate for Enhancing Drug Delivery
This article is part of the Bioconjugate Therapeutics special issue.
Mol. Pharmaceutics, 2017, 14 (5), pp 1325–1338
DOI: 10.1021/acs.molpharmaceut.6b01027

Tracking Antibody Distribution with Near-Infrared Fluorescent Dyes: Impact of Dye Structure and Degree of Labeling on Plasma Clearance
Open access through Editors’ Choice
Mol. Pharmaceutics, 2017, 14 (5), pp 1623–1633
DOI: 10.1021/acs.molpharmaceut.6b01091

Encapsulation of Ibuprofen in CD-MOF and Related Bioavailability Studies
Mol. Pharmaceutics, 2017, 14 (5), pp 1831–1839
DOI: 10.1021/acs.molpharmaceut.7b00168

Clinically Relevant Multidrug Transporters Are Regulated by microRNAs along the Human Intestine
Open access through Editors’ Choice
Mol. Pharmaceutics, 2017, 14 (7), pp 2245–2253
DOI: 10.1021/acs.molpharmaceut.7b00076

Biocompatible Injectable Hydrogel with Potent Wound Healing and Antibacterial Properties
Mol. Pharmaceutics, 2017, 14 (4), pp 1218–1230
DOI: 10.1021/acs.molpharmaceut.6b01104

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Organic Letters

Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine
Org. Lett., 2017, 19 (19), pp 5150–5153
DOI: 10.1021/acs.orglett.7b02434

Enantioselective Total Synthesis of (+)-Sieboldine A
Open access through Editors’ Choice
Org. Lett., 2017, 19 (2), pp 320–323
DOI: 10.1021/acs.orglett.6b03416

B(C6F5)3-Catalyzed Michael Reactions: Aromatic C–H as Nucleophiles
Open access through Editors’ Choice
Org. Lett., 2017, 19 (10), pp 2568–2571
DOI: 10.1021/acs.orglett.7b00720

Enantioselective Synthesis of (−)-Acetylapoaranotin
Open access through Editors’ Choice
Org. Lett., 2017, 19 (7), pp 1698–1701
DOI: 10.1021/acs.orglett.7b00418

Pd-Catalyzed Ortho C–H Hydroxylation of Benzaldehydes Using a Transient Directing Group
Open access through Editors’ Choice
Org. Lett., 2017, 19 (23), pp 6280–6283
DOI: 10.1021/acs.orglett.7b02906

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Organic Process Research & Development

BMS-663068: Another Quiet Victory for Chemistry
Open access through Editors’ Choice
Org. Process Res. Dev., 2017, 21 (8), pp 1091–1094
DOI: 10.1021/acs.oprd.7b00208

General Principles and Strategies for Salting-Out Informed by the Hofmeister Series
Open access through ACS AuthorChoice
Org. Process Res. Dev., 2017, 21 (9), pp 1355–1370
DOI: 10.1021/acs.oprd.7b00197

One-Step Continuous Flow Synthesis of Antifungal WHO Essential Medicine Flucytosine Using Fluorine
Open access through Editors’ Choice
Org. Process Res. Dev., 2017, 21 (2), pp 273–276
DOI: 10.1021/acs.oprd.6b00420

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2017, 21 (6), pp 789–799
DOI: 10.1021/acs.oprd.7b00193

Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times
Open access through Editors’ Choice
Org. Process Res. Dev., 2017, 21 (9), pp 1294–1301
DOI: 10.1021/acs.oprd.7b00173

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Organometallics

Synthesis, Reactivity, and Catalytic Applications of Isolable (NHC)Cu(CHF2) Complexes
Open access through Editors’ Choice
Organometallics, 2017, 36 (7), pp 1220–1223
DOI: 10.1021/acs.organomet.7b00025

A New Mode of Operation of Pd-NHC Systems Studied in a Catalytic Mizoroki–Heck Reaction
Open access through Editors’ Choice
Organometallics, 2017, 36 (10), pp 1981–1992
DOI: 10.1021/acs.organomet.7b00184

Toxicity of Metal Compounds: Knowledge and Myths
Open access through ACS AuthorChoice
Organometallics, 2017, 36 (21), pp 4071–4090
DOI: 10.1021/acs.organomet.7b00605

Evaluating 1,1′-Bis(phosphino)ferrocene Ancillary Ligand Variants in the Nickel-Catalyzed C–N Cross-Coupling of (Hetero)aryl Chlorides
Open access through Editors’ Choice
Organometallics, 2017, 36 (3), pp 679–686
DOI: 10.1021/acs.organomet.6b00885

Flipping the Oxidation State Formalism: Charge Distribution in Organometallic Complexes As Reported by Carbon Monoxide
Organometallics, 2017, 36 (3), pp 622–631
DOI: 10.1021/acs.organomet.6b00820

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