Discover the Most-Read Biological Chemistry Articles of February 2018

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in February 2018, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of February’s most-read articles: Analytical | Applied  | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical

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ACS Biomaterials Science & Engineering

3D Microtissue Models to Analyze the Effects of Ultralow Dose LPS on Vascular Sprouting Dynamics in the Tumor Microenvironment
This article is part of the Tissue Engineering and Biomaterials Approaches to Tumor Modeling special issue.
ACS Biomater. Sci. Eng., 2018, 4 (2), pp 357–367
DOI: 10.1021/acsbiomaterials.6b00800

3D Printed Fe Scaffolds with HA Nanocoating for Bone Regeneration
ACS Biomater. Sci. Eng., 2018, 4 (2), pp 608–616
DOI: 10.1021/acsbiomaterials.7b00885

3D Printing of PDMS Improves Its Mechanical and Cell Adhesion Properties
ACS Biomater. Sci. Eng., 2018, 4 (2), pp 682–693
DOI: 10.1021/acsbiomaterials.7b00646

3D Tissue Engineered in Vitro Models of Cancer in Bone
This article is part of the Tissue Engineering and Biomaterials Approaches to Tumor Modeling special issue.
ACS Biomater. Sci. Eng.
, 2018, 4 (2), pp 324–336
DOI: 10.1021/acsbiomaterials.7b00097

Editorial: Special Issue on Tissue Engineering and Biomaterials Approaches to Tumor Modeling
This article is part of the Tissue Engineering and Biomaterials Approaches to Tumor Modeling special issue.
ACS Biomater. Sci. Eng., 2018, 4 (2), pp 291–293
DOI: 10.1021/acsbiomaterials.8b00085

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ACS Catalysis

Advances in Direct Metal-Catalyzed Functionalization of Azobenzenes
ACS Catal., 2018, 8 (2), pp 1546–1579
DOI: 10.1021/acscatal.7b03583

Carbon Modification of Nickel Catalyst for Depolymerization of Oxidized Lignin to Aromatics
ACS Catal., 2018, 8 (2), pp 1614–1620
DOI: 10.1021/acscatal.7b03475

Direct Synthesis of H2O2 from H2 and O2 on Pd Catalysts: Current Understanding, Outstanding Questions, and Research Needs
ACS Catal., 2018, 8 (2), pp 1520–1527
DOI: 10.1021/acscatal.7b04107

Dual Role of a Photocatalyst: Generation of Ni(0) Catalyst and Promotion of Catalytic C–N Bond Formation
ACS Catal., 2018, 8 (2), pp 1456–1463
DOI: 10.1021/acscatal.7b03024

Facile Ammonia Synthesis from Electrocatalytic N2 Reduction under Ambient Conditions on N-Doped Porous Carbon
ACS Catal., 2018, 8 (2), pp 1186–1191
DOI: 10.1021/acscatal.7b02165

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ACS Chemical Biology

A Single-Chain Photoswitchable CRISPR-Cas9 Architecture for Light-Inducible Gene Editing and Transcription
This article is part of the Chemical Biology of CRISPR special issue.
Open Access Through ACS AuthorChoice
ACS Chem. Biol., 2018, 13 (2), pp 443–448
DOI: 10.1021/acschembio.7b00603

CRISPR Approaches to Small Molecule Target Identification
This article is part of the Chemical Biology of CRISPR special issue.
ACS Chem. Biol., 2018, 13 (2), pp 366–375
DOI: 10.1021/acschembio.7b00965

CRISPR-Mediated Tagging of Endogenous Proteins with a Luminescent Peptide
This article is part of the Chemical Biology of CRISPR special issue.
Open Access Through ACS AuthorChoice
ACS Chem. Biol., 2018, 13 (2), pp 467–474
DOI: 10.1021/acschembio.7b00549

CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine
This article is part of the Chemical Biology of CRISPR special issue.
ACS Chem. Biol., 2018, 13 (2), pp 406–416
DOI: 10.1021/acschembio.7b00657

Editing the Genome Without Double-Stranded DNA Breaks
This article is part of the Chemical Biology of CRISPR special issue.
ACS Chem. Biol., 2018, 13 (2), pp 383–388
DOI: 10.1021/acschembio.7b00710

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ACS Chemical Neuroscience

An Overview of the Clinical Uses, Pharmacology, and Safety of Modafinil
ACS Chem. Neurosci., 2018, 9 (2), pp 151–158
DOI: 10.1021/acschemneuro.7b00374

Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer’s Disease
ACS Chem. Neurosci., 2018, 9 (2), pp 328–345
DOI: 10.1021/acschemneuro.7b00345

Development of μ-Low-Flow-Push–Pull Perfusion Probes for Ex Vivo Sampling from Mouse Hippocampal Tissue Slices
Open Access Through ACS AuthorChoice
ACS Chem. Neurosci., 2018, 9 (2), pp 252–259
DOI: 10.1021/acschemneuro.7b00277

Drug Target Discovery Methods In Targeting Neurotropic Parasitic Amoebae
ACS Chem. Neurosci., 2018, 9 (2), pp 162–164
DOI: 10.1021/acschemneuro.7b00492

Global Neuroscience: China
ACS Chem. Neurosci., 2018, 9 (2), pp 138–139
DOI: 10.1021/acschemneuro.8b00048

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ACS Infectious Diseases

Broad Spectrum Inhibitor of Influenza A and B Viruses Targeting the Viral Nucleoprotein
ACS Infect. Dis., 2018, 4 (2), pp 146–157
DOI: 10.1021/acsinfecdis.7b00120

C8-Linked Pyrrolobenzodiazepine Monomers with Inverted Building Blocks Show Selective Activity against Multidrug Resistant Gram-Positive Bacteria
Open Access Through ACS AuthorChoice
ACS Infect. Dis., 2018, 4 (2), pp 158–174
DOI: 10.1021/acsinfecdis.7b00130

Combating Intracellular Pathogens with Repurposed Host-Targeted Drugs
ACS Infect. Dis., 2018, 4 (2), pp 88–92
DOI: 10.1021/acsinfecdis.7b00268

Game Changers: New β-Lactamase Inhibitor Combinations Targeting Antibiotic Resistance in Gram-Negative Bacteria
ACS Infect. Dis., 2018, 4 (2), pp 84–87
DOI: 10.1021/acsinfecdis.7b00243

Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus
ACS Infect. Dis., 2018, 4 (2), pp 175–184
DOI: 10.1021/acsinfecdis.7b00134

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ACS Medicinal Chemistry Letters

Click-Addressable Cassette for Photoaffinity Labeling
ACS Med. Chem. Lett., 2018, 9 (2), pp 155–158
DOI: 10.1021/acsmedchemlett.7b00516

Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors
ACS Med. Chem. Lett., 2018, 9 (2), pp 125–130
DOI: 10.1021/acsmedchemlett.7b00481

Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin’s Lymphoma
ACS Med. Chem. Lett., 2018, 9 (2), pp 98–102
DOI: 10.1021/acsmedchemlett.7b00437

From RORγt Agonist to Two Types of RORγt Inverse Agonists
ACS Med. Chem. Lett., 2018, 9 (2), pp 120–124
DOI: 10.1021/acsmedchemlett.7b00476

Identification of Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors Based on a Phenylimidazole Scaffold
ACS Med. Chem. Lett., 2018, 9 (2), pp 131–136
DOI: 10.1021/acsmedchemlett.7b00488

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ACS Synthetic Biology

An Expanded Plasmid-Based Genetic Toolbox Enables Cas9 Genome Editing and Stable Maintenance of Synthetic Pathways in Phaeodactylum tricornutum
ACS Synth. Biol., 2018, 7 (2), pp 328–338
DOI: 10.1021/acssynbio.7b00191

Analyzing and Tuning Ribozyme Activity by Deep Sequencing To Modulate Gene Expression Level in Mammalian Cells
Open Access Through ACS AuthorChoice
ACS Synth. Biol., 2018, 7 (2), pp 371–376
DOI: 10.1021/acssynbio.7b00367

Biosynthesis of Orthogonal Molecules Using Ferredoxin and Ferredoxin-NADP+ Reductase Systems Enables Genetically Encoded PhyB Optogenetics
Open Access Through ACS AuthorChoice
ACS Synth. Biol., 2018, 7 (2), pp 706–717
DOI: 10.1021/acssynbio.7b00413

Deformation Modes of Giant Unilamellar Vesicles Encapsulating Biopolymers
ACS Synth. Biol., 2018, 7 (2), pp 739–747
DOI: 10.1021/acssynbio.7b00460

Detection of a Peptide Biomarker by Engineered Yeast Receptors
Open Access Through ACS AuthorChoice
ACS Synth. Biol., 2018, 7 (2), pp 696–705
DOI: 10.1021/acssynbio.7b00410

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Biochemistry

A New Step in the Treatment of Sickle Cell Disease
Biochemistry, 2018, 57 (5), pp 470–471
DOI: 10.1021/acs.biochem.7b00785

Another One (of the “Undruggable” Targets) Bites the Dust: Discovery of a Potent and Selective Inhibitor of the Histone Acetyl Transferase p300/CBP
Biochemistry, 2018, 57 (6), pp 899–900
DOI: 10.1021/acs.biochem.7b01179

Biosynthesis of the Antibiotic Bicyclomycin in Soil and Pathogenic Bacteria
Biochemistry, 2018, 57 (6), pp 897–898
DOI: 10.1021/acs.biochem.7b01204

Introducing Biochemistry to Bedside
Biochemistry, 2018, 57 (5), pp 469–469
DOI: 10.1021/acs.biochem.7b01217

Microbiota-Regulated Outcomes of Human Cancer Immunotherapy via the PD-1/PD-L1 Axis
Biochemistry, 2018, 57 (6), pp 901–903
DOI: 10.1021/acs.biochem.7b01249

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Bioconjugate Chemistry

a-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity
Open Access Through ACS AuthorChoice
Bioconjugate Chem., 2018, 29 (2), pp 316–323
DOI: 10.1021/acs.bioconjchem.7b00648

Bioorthogonal Masking of Circulating Antibody–TCO Groups Using Tetrazine-Functionalized Dextran Polymers
Bioconjugate Chem., 2018, 29 (2), pp 538–545
DOI: 10.1021/acs.bioconjchem.8b00028

CRISPRed Macrophages for Cell-Based Cancer Immunotherapy
Bioconjugate Chem., 2018, 29 (2), pp 445–450
DOI: 10.1021/acs.bioconjchem.7b00768

High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers
Bioconjugate Chem., 2018, 29 (2), pp 473–485
DOI: 10.1021/acs.bioconjchem.7b00791

Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody–Drug Conjugates with Phenol-Containing Payloads
Bioconjugate Chem., 2018, 29 (2), pp 267–274
DOI: 10.1021/acs.bioconjchem.7b00576

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Biomacromolecules

Antibacterial and Biocompatible Cross-Linked Waterborne Polyurethanes Containing Gemini Quaternary Ammonium Salts
Biomacromolecules, 2018, 19 (2), pp 279–287
DOI: 10.1021/acs.biomac.7b01016

Design of Pickering Micro- and Nanoemulsions Based on the Structural Characteristics of Nanocelluloses
Biomacromolecules, 2018, 19 (2), pp 460–469
DOI: 10.1021/acs.biomac.7b01564

Dissolution of Cellulosic Fibers: Impact of Crystallinity and Fiber Diameter
Biomacromolecules, 2018, 19 (2), pp 640–651
DOI: 10.1021/acs.biomac.7b01745

Dual Function Injectable Hydrogel for Controlled Release of Antibiotic and Local Antibacterial Therapy
Biomacromolecules, 2018, 19 (2), pp 267–278
DOI: 10.1021/acs.biomac.7b00979

Injectable Hydrogel with Slow Degradability Composed of Gelatin and Hyaluronic Acid Cross-Linked by Schiff’s Base Formation
Biomacromolecules, 2018, 19 (2), pp 288–297
DOI: 10.1021/acs.biomac.7b01133

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Journal of Agricultural and Food Chemistry

Chitinase Chi1 from Myceliophthora thermophila C1, a Thermostable Enzyme for Chitin and Chitosan Depolymerization
Open Access Through ACS AuthorChoice
J. Agric. Food Chem., 2018, 66 (7), pp 1658–1669
DOI: 10.1021/acs.jafc.7b04032

Complexity of Advanced Glycation End Products in Foods: Where Are We Now?
J. Agric. Food Chem., 2018, 66 (6), pp 1325–1329
DOI: 10.1021/acs.jafc.7b05955

Curcumin: An Effective or Deceptive Dietary Factor? Challenges for Functional Food Scientists
J. Agric. Food Chem., 2018, 66 (5), pp 1059–1060
DOI: 10.1021/acs.jafc.7b05878

Different Phosphorus Supplies Altered the Accumulations and Quantitative Distributions of Phytic Acid, Zinc, and Iron in Rice (Oryza sativa L.) Grains
J. Agric. Food Chem., 2018, 66 (7), pp 1601–1611
DOI: 10.1021/acs.jafc.7b04883

Enhancement of Curcumin Bioavailability by Encapsulation in Sophorolipid-Coated Nanoparticles: An in Vitro and in Vivo Study
J. Agric. Food Chem., 2018, 66 (6), pp 1488–1497
DOI: 10.1021/acs.jafc.7b05478

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Journal of Chemical Theory and Computation

Benchmarking Excited-State Calculations Using Exciton Properties
J. Chem. Theory Comput., 2018, 14 (2), pp 710–725
DOI: 10.1021/acs.jctc.7b01145

Calculation of Diffusion Coefficients through Coarse-Grained Simulations Using the Automated-Fragmentation-Parametrization Method and the Recovery of Wilke–Chang Statistical Correlation
Open Access Through ACS AuthorChoice
J. Chem. Theory Comput., 2018, 14 (2), pp 479–485
DOI: 10.1021/acs.jctc.7b01093

Characterizing Hydration Properties Based on the Orientational Structure of Interfacial Water Molecules
J. Chem. Theory Comput., 2018, 14 (2), pp 461–465
DOI: 10.1021/acs.jctc.7b00898

Embedded Multireference Coupled Cluster Theory
J. Chem. Theory Comput., 2018, 14 (2), pp 693–709
DOI: 10.1021/acs.jctc.7b01144

Fast Calculation of Protein–Protein Binding Free Energies Using Umbrella Sampling with a Coarse-Grained Model
J. Chem. Theory Comput., 2018, 14 (2), pp 991–997
DOI: 10.1021/acs.jctc.7b00660

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Journal of Medicinal Chemistry

Allosteric Modulators of Drug Targets Special Issue
J. Med. Chem., 2018, 61 (4), pp 1381–1381
DOI: 10.1021/acs.jmedchem.8b00171

BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer’s Disease
J. Med. Chem., 2018, 61 (3), pp 619–637
DOI: 10.1021/acs.jmedchem.7b00393

Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists
J. Med. Chem., 2018, 61 (3), pp 681–694
DOI: 10.1021/acs.jmedchem.7b00982

Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo
Open Access Through ACS Editors’ Choice
J. Med. Chem., 2018, 61 (3), pp 865–880
DOI: 10.1021/acs.jmedchem.7b01371

Free Energy Methods in Drug Design: Prospects of “Alchemical Perturbation” in Medicinal Chemistry
J. Med. Chem., 2018, 61 (3), pp 638–649
DOI: 10.1021/acs.jmedchem.7b00681

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Journal of Natural Products

Cybastacines A and B: Antibiotic Sesterterpenes from a Nostoc sp. Cyanobacterium
J. Nat. Prod., 2018, 81 (2), pp 410–413
DOI: 10.1021/acs.jnatprod.7b00638

Cyclizidine-Type Alkaloids from Streptomyces sp. HNA39
J. Nat. Prod., 2018, 81 (2), pp 394–399
DOI: 10.1021/acs.jnatprod.7b01055

Hamigerans R and S: Nitrogenous Diterpenoids from the New Zealand Marine Sponge Hamigera tarangaensis
J. Nat. Prod., 2018, 81 (2), pp 387–393
DOI: 10.1021/acs.jnatprod.7b00960

Lipovelutibols A–D: Cytotoxic Lipopeptaibols from the Himalayan Cold Habitat Fungus Trichoderma velutinum
J. Nat. Prod., 2018, 81 (2), pp 219–226
DOI: 10.1021/acs.jnatprod.6b00873

Metabolomics-Guided Discovery of Microginin Peptides from Cultures of the Cyanobacterium Microcystis aeruginosa
J. Nat. Prod., 2018, 81 (2), pp 349–355
DOI: 10.1021/acs.jnatprod.7b00829

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The Journal of Physical Chemistry B

CO2 Diffusion in Various Carbonated Beverages: A Molecular Dynamics Study
J. Phys. Chem. B, 2018, 122 (5), pp 1655–1661
DOI: 10.1021/acs.jpcb.7b10469

Fluorescence and Excited-State Conformational Dynamics of the Orange Carotenoid Protein
J. Phys. Chem. B, 2018, 122 (6), pp 1792–1800
DOI: 10.1021/acs.jpcb.7b09435

Hydrophilic Solvation Dominates the Terahertz Fingerprint of Amino Acids in Water
J. Phys. Chem. B, 2018, 122 (4), pp 1453–1459
DOI: 10.1021/acs.jpcb.7b08563

Machine Learning
J. Phys. Chem. B, 2018, 122 (4), pp 1347–1347
DOI: 10.1021/acs.jpcb.8b00035

Molecular Dynamics Investigation of the Influence of the Hydrogen Bond Networks in Ethanol/Water Mixtures on Dielectric Spectra
Open Access Through ACS AuthorChoice
J. Phys. Chem. B, 2018, 122 (4), pp 1505–1515
DOI: 10.1021/acs.jpcb.7b12220

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The Journal of Physical Chemistry Letters

All-Solid-State Batteries with Thick Electrode Configurations
J. Phys. Chem. Lett., 2018, 9 (3), pp 607–613
DOI: 10.1021/acs.jpclett.7b02880

Coupling of Elementary Electronic Excitations: Drawing Parallels Between Excitons and Plasmons
J. Phys. Chem. Lett., 2018, 9 (4), pp 919–932
DOI: 10.1021/acs.jpclett.7b01833

Dynamic Control of Particle Deposition in Evaporating Droplets by an External Point Source of Vapor
Open Access Through ACS AuthorChoice
J. Phys. Chem. Lett., 2018, 9 (3), pp 659–664
DOI: 10.1021/acs.jpclett.7b02831

Enhanced Performance of Red Perovskite Light-Emitting Diodes through the Dimensional Tailoring of Perovskite Multiple Quantum Wells
J. Phys. Chem. Lett., 2018, 9 (4), pp 881–886
DOI: 10.1021/acs.jpclett.7b03417

Enhanced Thermal Stability in Perovskite Solar Cells by Assembling 2D/3D Stacking Structures
J. Phys. Chem. Lett., 2018, 9 (3), pp 654–658
DOI: 10.1021/acs.jpclett.7b02679

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Journal of Proteome Research

BioSITe: A Method for Direct Detection and Quantitation of Site-Specific Biotinylation
J. Proteome Res., 2018, 17 (2), pp 759–769
DOI: 10.1021/acs.jproteome.7b00775

Exploring ECD on a Benchtop Q Exactive Orbitrap Mass Spectrometer
Open Access Through ACS AuthorChoice
J. Proteome Res., 2018, 17 (2), pp 926–933
DOI: 10.1021/acs.jproteome.7b00622

iTRAQ-Based Proteomic Analysis Reveals Recovery of Impaired Mitochondrial Function in Ischemic Myocardium by Shenmai Formula
J. Proteome Res., 2018, 17 (2), pp 794–803
DOI: 10.1021/acs.jproteome.7b00450

Metabonomics Approach To Comparing the Antistress Effects of Four Panax ginseng Components in Rats
J. Proteome Res., 2018, 17 (2), pp 813–821
DOI: 10.1021/acs.jproteome.7b00559

Mining the Secretome of C2C12 Muscle Cells: Data Dependent Experimental Approach To Analyze Protein Secretion Using Label-Free Quantification and Peptide Based Analysis
J. Proteome Res., 2018, 17 (2), pp 879–890
DOI: 10.1021/acs.jproteome.7b00684

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Molecular Pharmaceutics

ATP-Binding Cassette Transporter A Subfamily 8 Is a Sinusoidal Efflux Transporter for Cholesterol and Taurocholate in Mouse and Human Liver
Mol. Pharmaceutics, 2018, 15 (2), pp 343–355
DOI: 10.1021/acs.molpharmaceut.7b00679

Comparison of the Expression Kinetics and Immunostimulatory Activity of Replicating mRNA, Nonreplicating mRNA, and pDNA after Intradermal Electroporation in Pigs
Mol. Pharmaceutics, 2018, 15 (2), pp 377–384
DOI: 10.1021/acs.molpharmaceut.7b00722

Difluoromethylornithine Combined with a Polyamine Transport Inhibitor Is Effective against Gemcitabine Resistant Pancreatic Cancer
Mol. Pharmaceutics, 2018, 15 (2), pp 369–376
DOI: 10.1021/acs.molpharmaceut.7b00718

Facile Deposition of Manganese Dioxide to Albumin-Bound Paclitaxel Nanoparticles for Modulation of Hypoxic Tumor Microenvironment To Improve Chemoradiation Therapy
Mol. Pharmaceutics, 2018, 15 (2), pp 447–457
DOI: 10.1021/acs.molpharmaceut.7b00808

Metal Protein-Attenuating Compound for PET Neuroimaging: Synthesis and Preclinical Evaluation of [11C]PBT2
Mol. Pharmaceutics, 2018, 15 (2), pp 695–702
DOI: 10.1021/acs.molpharmaceut.7b00936

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