Discover the Most-Read Biological Chemistry Articles of April 2018

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in April 2018, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of April’s most-read articles: Analytical | AppliedMaterials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical

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ACS Biomaterials Science & Engineering

Regenerative Biomaterials
This article is part of the Regenerative Biomaterials special issue.
ACS Biomater. Sci. Eng., 2018, 4 (4), pp 1113–1114
DOI: 10.1021/acsbiomaterials.8b00358

Materials-Directed Differentiation of Mesenchymal Stem Cells for Tissue Engineering and Regeneration
This article is part of the Regenerative Biomaterials special issue.
ACS Biomater. Sci. Eng., 2018, 4 (4), pp 1115–1127
DOI: 10.1021/acsbiomaterials.6b00741

Raman Spectroscopy for Advanced Polymeric Biomaterials
ACS Biomater. Sci. Eng., 2018, 4 (4), pp 1285–1299
DOI: 10.1021/acsbiomaterials.8b00258

Biodegradable Water-Based Polyurethane Shape Memory Elastomers for Bone Tissue Engineering
ACS Biomater. Sci. Eng., 2018, 4 (4), pp 1397–1406
DOI: 10.1021/acsbiomaterials.8b00091

Multidomain Peptide Hydrogel Accelerates Healing of Full-Thickness Wounds in Diabetic Mice
ACS Biomater. Sci. Eng., 2018, 4 (4), pp 1386–1396
DOI: 10.1021/acsbiomaterials.8b00031

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ACS Catalysis

Challenges and Prospects in Solar Water Splitting and CO2 Reduction with Inorganic and Hybrid Nanostructures
ACS Catal., 2018, 8 (4), pp 3602–3635
DOI: 10.1021/acscatal.8b00791

Anion-Containing Noble-Metal-Free Bifunctional Electrocatalysts for Overall Water Splitting
ACS Catal., 2018, 8 (4), pp 3688–3707
DOI: 10.1021/acscatal.7b04286

Trends in the Catalytic Activity of Hydrogen Evolution during CO2 Electroreduction on Transition Metals
ACS Catal., 2018, 8 (4), pp 3035–3040
DOI: 10.1021/acscatal.7b03807

Cooperation between holey graphene and NiMo alloy for hydrogen evolution in an acidic electrolyte
ACS Catal., 2018, 8 (4), pp 3579–3586
DOI: 10.1021/acscatal.7b04091

Palladium-Catalyzed Synthesis of Diaryl Ketones from Aldehydes and (Hetero)Aryl Halides via C–H Bond Activation
ACS Catal., 2018, 8 (4), pp 3123–3128
DOI: 10.1021/acscatal.8b00440

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ACS Chemical Biology

Playing with the Molecules of Life
ACS Chem. Biol., 2018, 13 (4), pp 854–870
DOI: 10.1021/acschembio.7b00974

Thienyl-Substituted α-Ketoamide: A Less Hydrophobic Reactive Group for Photo-Affinity Labeling
ACS Chem. Biol., 2018, 13 (4), pp 876–880
DOI: 10.1021/acschembio.7b00988

Targeting Ligandable Pockets on Plant Homeodomain (PHD) Zinc Finger Domains by a Fragment-Based Approach
Open access through ACS AuthorChoice
ACS Chem. Biol., 2018, 13 (4), pp 915–921
DOI: 10.1021/acschembio.7b01093

Antimicrobial Metallopeptides
ACS Chem. Biol., 2018, 13 (4), pp 844–853
DOI: 10.1021/acschembio.7b00989

Determination of the Subcellular Localization and Mechanism of Action of Ferrostatins in Suppressing Ferroptosis
ACS Chem. Biol., 2018, 13 (4), pp 1013–1020
DOI: 10.1021/acschembio.8b00199

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ACS Chemical Neuroscience

Genetic and Rare Disease of the CNS. Part II: Holoprosencephaly (HPE)
ACS Chem. Neurosci., 2018, 9 (4), pp 626–627
DOI: 10.1021/acschemneuro.8b00135

Bridging Multiple Dementias
ACS Chem. Neurosci., 2018, 9 (4), pp 636–638
DOI: 10.1021/acschemneuro.8b00119

Beyond Fluorescent Proteins: Hybrid and Bioluminescent Indicators for Imaging Neural Activities
ACS Chem. Neurosci., 2018, 9 (4), pp 639–650
DOI: 10.1021/acschemneuro.7b00455

Pharmacogenomics and the Placebo Response
ACS Chem. Neurosci., 2018, 9 (4), pp 633–635
DOI: 10.1021/acschemneuro.8b00078

Thermodynamics of Amyloid-β Fibril Elongation: Atomistic Details of the Transition State
Open access through ACS AuthorChoice
ACS Chem. Neurosci., 2018, 9 (4), pp 783–789
DOI: 10.1021/acschemneuro.7b00409

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ACS Infectious Diseases

Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry
Open access through ACS Editors’ Choice
ACS Infect. Dis., 2018, 4 (4), pp 431–444
DOI: 10.1021/acsinfecdis.7b00197

Targeting the Proteostasis Network for Mycobacterial Drug Discovery
Open access through ACS AuthorChoice
ACS Infect. Dis., 2018, 4 (4), pp 478–498
DOI: 10.1021/acsinfecdis.7b00231

2nd SCI/RSC Symposium on Medicinal Chemistry for Global Health: A Unique Opportunity for the Field
ACS Infect. Dis., 2018, 4 (4), pp 424–428
DOI: 10.1021/acsinfecdis.8b00022

Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects
Open access through ACS AuthorChoice
ACS Infect. Dis., 2018, 4 (4), pp 467–477
DOI: 10.1021/acsinfecdis.7b00244

Special Issue on Drug Discovery for Global Health
This article is part of the Drug Discovery for Global Health special issue.
ACS Infect. Dis., 2018, 4 (4), pp 429–430
DOI: 10.1021/acsinfecdis.8b00055

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ACS Medicinal Chemistry Letters

Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
Open access through ACS AuthorChoice
ACS Med. Chem. Lett., 2018, 9 (4), pp 300–305
DOI: 10.1021/acsmedchemlett.7b00421

Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors
ACS Med. Chem. Lett., 2018, 9 (4), pp 312–317
DOI: 10.1021/acsmedchemlett.7b00487

Azabicyclic Fused Pyrimidine Derivatives Useful for the Treatment of Alzheimer’s Disease
ACS Med. Chem. Lett., 2018, 9 (4), pp 290–291
DOI: 10.1021/acsmedchemlett.8b00086

Modulating ADME Properties by Fluorination: MK2 Inhibitors with Improved Oral Exposure
ACS Med. Chem. Lett., 2018, 9 (4), pp 392–396
DOI: 10.1021/acsmedchemlett.8b00098

ATR Inhibitors as Potential Treatment for Cancers
ACS Med. Chem. Lett., 2018, 9 (4), pp 292–293
DOI: 10.1021/acsmedchemlett.8b00107

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ACS Synthetic Biology

Remote Control of Mammalian Cells with Heat-Triggered Gene Switches and Photothermal Pulse Trains
ACS Synth. Biol., 2018, 7 (4), pp 1167–1173
DOI: 10.1021/acssynbio.7b00455

Rational Design of Mini-Cas9 for Transcriptional Activation
ACS Synth. Biol., 2018, 7 (4), pp 978–985
DOI: 10.1021/acssynbio.7b00404

MIDAS: A Modular DNA Assembly System for Synthetic Biology
ACS Synth. Biol., 2018, 7 (4), pp 1018–1029
DOI: 10.1021/acssynbio.7b00363

Cameo: A Python Library for Computer Aided Metabolic Engineering and Optimization of Cell Factories
Open access through ACS AuthorChoice
ACS Synth. Biol., 2018, 7 (4), pp 1163–1166
DOI: 10.1021/acssynbio.7b00423

T7 Polymerase Expression of Guide RNAs in vivo Allows Exportable CRISPR-Cas9 Editing in Multiple Yeast Hosts
ACS Synth. Biol., 2018, 7 (4), pp 1075–1084
DOI: 10.1021/acssynbio.7b00461

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Biochemistry

Installation of the Ether Bridge of Lolines by the Iron- and 2-Oxoglutarate-Dependent Oxygenase, LolO: Regio- and Stereochemistry of Sequential Hydroxylation and Oxacyclization Reactions
Open access through ACS Editors’ Choice
Biochemistry, 2018, 57 (14), pp 2074–2083
DOI: 10.1021/acs.biochem.8b00157

Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy
Biochemistry, 2018, 57 (14), pp 2059–2060
DOI: 10.1021/acs.biochem.8b00307

Semisynthetic Organisms with Expanded Genetic Codes
Biochemistry, 2018, 57 (15), pp 2177–2178
DOI: 10.1021/acs.biochem.8b00013

Gut Microbiota: Rational Manipulation of Gut Bacterial Metalloenzymes Provides Insights into Dysbiosis and Inflammation
Biochemistry, 2018, 57 (16), pp 2291–2293
DOI: 10.1021/acs.biochem.8b00340

Rational Engineering of Multiple Active Sites in an Ester Hydrolase
Open access through ACS AuthorChoice
Biochemistry, 2018, 57 (15), pp 2245–2255
DOI: 10.1021/acs.biochem.8b00274

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Bioconjugate Chemistry

Advances in Polymer Design for Enhancing Oral Drug Solubility and Delivery
Bioconjugate Chem., 2018, 29 (4), pp 939–952
DOI: 10.1021/acs.bioconjchem.7b00646

Intracellular Peptide Self-Assembly: A Biomimetic Approach for in Situ Nanodrug Preparation
This article is part of the Biomimetic Materials special issue.
Bioconjugate Chem., 2018, 29 (4), pp 826–837
DOI: 10.1021/acs.bioconjchem.7b00798

Modulating Antibody–Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification
Bioconjugate Chem., 2018, 29 (4), pp 1155–1167
DOI: 10.1021/acs.bioconjchem.7b00785

A Fluorescent Probe for Stimulated Emission Depletion Super-Resolution Imaging of Vicinal-Dithiol-Proteins on Mitochondrial Membrane
Bioconjugate Chem., 2018, 29 (4), pp 1446–1453
DOI: 10.1021/acs.bioconjchem.8b00128

Vinylboronic Acids as Efficient Bioorthogonal Reactants for Tetrazine Labeling in Living Cells
Open access through ACS AuthorChoice
Bioconjugate Chem., 2018, 29 (4), pp 982–986
DOI: 10.1021/acs.bioconjchem.7b00796

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Biomacromolecules

Guanidinium-Functionalized Interpolyelectrolyte Complexes Enabling RNAi in Resistant Insect Pests
Open access through ACS Editors’ Choice
Biomacromolecules, 2018, 19 (4), pp 1111–1117
DOI: 10.1021/acs.biomac.7b01717

Squaramide-Based Supramolecular Materials for Three-Dimensional Cell Culture of Human Induced Pluripotent Stem Cells and Their Derivatives
Biomacromolecules, 2018, 19 (4), pp 1091–1099
DOI: 10.1021/acs.biomac.7b01614

Development of Fully Degradable Phosphonium-Functionalized Amphiphilic Diblock Copolymers for Nucleic Acids Delivery
Open access through ACS Editors’ Choice
Biomacromolecules, 2018, 19 (4), pp 1212–1222
DOI: 10.1021/acs.biomac.8b00069

Stimulus-Responsive Peptide for Effective Delivery and Release of DNA in Plants
Open access through ACS AuthorChoice
Biomacromolecules, 2018, 19 (4), pp 1154–1163
DOI: 10.1021/acs.biomac.8b00016

Hyaluronic Acid/Chitosan Coacervate-Based Scaffolds
Biomacromolecules, 2018, 19 (4), pp 1198–1211
DOI: 10.1021/acs.biomac.8b00047

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Journal of Agricultural and Food Chemistry

Food Design To Feed the Human Gut Microbiota
Open access through ACS AuthorChoice
J. Agric. Food Chem., 2018, 66 (15), pp 3754–3758
DOI: 10.1021/acs.jafc.8b00456

Coencapsulation of (−)-Epigallocatechin-3-gallate and Quercetin in Particle-Stabilized W/O/W Emulsion Gels: Controlled Release and Bioaccessibility
J. Agric. Food Chem., 2018, 66 (14), pp 3691–3699
DOI: 10.1021/acs.jafc.7b05161

Polyphenols’ Gut Microbiota Metabolites: Bioactives or Biomarkers?
J. Agric. Food Chem., 2018, 66 (14), pp 3593–3594
DOI: 10.1021/acs.jafc.8b00827

What Do We Know about the Chemistry of Strawberry Aroma?
J. Agric. Food Chem., 2018, 66 (13), pp 3291–3301
DOI: 10.1021/acs.jafc.8b01115

Effective Enrichment and Detection of Trace Polycyclic Aromatic Hydrocarbons in Food Samples based on Magnetic Covalent Organic Framework Hybrid Microspheres
J. Agric. Food Chem., 2018, 66 (13), pp 3572–3580
DOI: 10.1021/acs.jafc.8b00869

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Journal of Medicinal Chemistry

Beyond the Rule of 5: Lessons Learned from AbbVie’s Drugs and Compound Collection
J. Med. Chem., 2018, 61 (7), pp 2636–2651
DOI: 10.1021/acs.jmedchem.7b00717

Fragment-Based Approach to Targeting Inosine-5′-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis
Open access through ACS AuthorChoice
J. Med. Chem., 2018, 61 (7), pp 2806–2822
DOI: 10.1021/acs.jmedchem.7b01622

Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer
J. Med. Chem., 2018, 61 (7), pp 2837–2864
DOI: 10.1021/acs.jmedchem.7b01682

Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson’s Disease Treatment
J. Med. Chem., 2018, 61 (7), pp 2776–2792
DOI: 10.1021/acs.jmedchem.7b01575

Structure-Based Discovery and Optimization of Benzo[d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)
J. Med. Chem., 2018, 61 (7), pp 3037–3058
DOI: 10.1021/acs.jmedchem.8b00103.

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Journal of Natural Products

Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation
Open access through ACS Editors’ Choice
J. Nat. Prod., 2018, 81 (4), pp 758–767
DOI: 10.1021/acs.jnatprod.7b00737

Isolation, Characterization, and Structure–Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors
J. Nat. Prod., 2018, 81 (4), pp 998–1006
DOI: 10.1021/acs.jnatprod.7b01082

Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine
J. Nat. Prod., 2018, 81 (4), pp 1029–1035
DOI: 10.1021/acs.jnatprod.8b00062

Total Synthesis of (±)-Minfiensine via a Formal [3+2] Cycloaddition
J. Nat. Prod., 2018, 81 (4), pp 1065–1069
DOI: 10.1021/acs.jnatprod.7b00873

Trichorenins A–C, Algicidal Tetracyclic Metabolites from the Marine-Alga-Epiphytic Fungus Trichoderma virens Y13-3
J. Nat. Prod., 2018, 81 (4), pp 1121–1124
DOI: 10.1021/acs.jnatprod.8b00164

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The Journal of Physical Chemistry B

Structure from Dynamics: Vibrational Dynamics of Interfacial Water as a Probe of Aqueous Heterogeneity
Open access through ACS Editors’ Choice
J. Phys. Chem. B, 2018, 122 (14), pp 3667–3679
DOI: 10.1021/acs.jpcb.7b10574

Empirical Classification of Trajectory Data: An Opportunity for the Use of Machine Learning in Molecular Dynamics
Open access through ACS AuthorChoice
J. Phys. Chem. B, 2018, 122 (13), pp 3230–3241
DOI: 10.1021/acs.jpcb.7b08707

Tribute to Benjamin Widom
This article is part of the Benjamin Widom Festschrift special issue.
J. Phys. Chem. B, 2018, 122 (13), pp 3203–3205
DOI: 10.1021/acs.jpcb.8b00129

Influence of Ion Solvation on the Properties of Electrolyte Solutions
J. Phys. Chem. B, 2018, 122 (14), pp 4029–4034
DOI: 10.1021/acs.jpcb.8b00518

One Peptide Reveals the Two Faces of α-Helix Unfolding–Folding Dynamics
J. Phys. Chem. B, 2018, 122 (14), pp 3790–3800
DOI: 10.1021/acs.jpcb.8b00229

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The Journal of Physical Chemistry Letters

Lead-Free Perovskite Nanocrystals for Light-Emitting Devices
J. Phys. Chem. Lett., 2018, 9 (7), pp 1573–1583
DOI: 10.1021/acs.jpclett.8b00301

Coherence from Light Harvesting to Chemistry
J. Phys. Chem. Lett., 2018, 9 (7), pp 1568–1572
DOI: 10.1021/acs.jpclett.8b00734

Ultrafast Charge Transfer in Perovskite Nanowire/2D Transition Metal Dichalcogenide Heterostructures
J. Phys. Chem. Lett., 2018, 9 (7), pp 1655–1662
DOI: 10.1021/acs.jpclett.8b00260

Shining Light on New-Generation Two-Dimensional Materials from a Computational Viewpoint
J. Phys. Chem. Lett., 2018, 9 (7), pp 1605–1612
DOI: 10.1021/acs.jpclett.8b00044

Realizing Highly Efficient Solution-Processed Homojunction-Like Sky-Blue OLEDs by Using Thermally Activated Delayed Fluorescent Emitters Featuring an Aggregation-Induced Emission Property
J. Phys. Chem. Lett., 2018, 9 (7), pp 1547–1553
DOI: 10.1021/acs.jpclett.8b00344

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Journal of Proteome Research

Conversations with 100 Scientists in the Field Reveal a Bifurcated Perception of the State of Mass Spectrometry Software
J. Proteome Res., 2018, 17 (4), pp 1335–1339
DOI: 10.1021/acs.jproteome.8b00015

Extending the Compatibility of the SP3 Paramagnetic Bead Processing Approach for Proteomics
J. Proteome Res., 2018, 17 (4), pp 1730–1740
DOI: 10.1021/acs.jproteome.7b00913

PACOM: A Versatile Tool for Integrating, Filtering, Visualizing, and Comparing Multiple Large Mass Spectrometry Proteomics Data Sets
J. Proteome Res., 2018, 17 (4), pp 1547–1558
DOI: 10.1021/acs.jproteome.7b00858

Optimized Phenotypic Biomarker Discovery and Confounder Elimination via Covariate-Adjusted Projection to Latent Structures from Metabolic Spectroscopy Data
Open access through ACS AuthorChoice
J. Proteome Res., 2018, 17 (4), pp 1586–1595
DOI: 10.1021/acs.jproteome.7b00879

Determination of Site-Specific Phosphorylation Ratios in Proteins with Targeted Mass Spectrometry
J. Proteome Res., 2018, 17 (4), pp 1654–1663
DOI: 10.1021/acs.jproteome.7b00911

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Molecular Pharmaceutics

Liposomal Codelivery of Doxorubicin and Andrographolide Inhibits Breast Cancer Growth and Metastasis
Mol. Pharmaceutics, 2018, 15 (4), pp 1618–1626
DOI: 10.1021/acs.molpharmaceut.7b01164

pH-Responsive Nanophotosensitizer for an Enhanced Photodynamic Therapy of Colorectal Cancer Overexpressing EGFR
Mol. Pharmaceutics, 2018, 15 (4), pp 1432–1444
DOI: 10.1021/acs.molpharmaceut.7b00925

A New Method of Constructing a Drug–Polymer Temperature–Composition Phase Diagram Using Hot-Melt Extrusion
Mol. Pharmaceutics, 2018, 15 (4), pp 1379–1391
DOI: 10.1021/acs.molpharmaceut.7b00445

In Vitro, in Silico, and in Vivo Assessments of Intestinal Precipitation and Its Impact on Bioavailability of a BCS Class 2 Basic Compound
Mol. Pharmaceutics, 2018, 15 (4), pp 1607–1617
DOI: 10.1021/acs.molpharmaceut.7b01143

Evaluation of an Anti-HER2 Nanobody Labeled with 225Ac for Targeted α-Particle Therapy of Cancer
Mol. Pharmaceutics, 2018, 15 (4), pp 1457–1466
DOI: 10.1021/acs.molpharmaceut.7b00985

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