Discover the Most-Read Organic/Inorganic Chemistry Articles of May 2018

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in May 2018, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of May’s most-read articles: AnalyticalApplied | Biological | Materials Science & Engineering | Multidisciplinary  | Physical 


ACS Catalysis

ACS Catalysis Appoints Second Early Career Advisory Board and New Associate Editor
ACS Catal., 2018, 8 (5), pp 4582–4582
DOI: 10.1021/acscatal.8b01493

Cross-Coupling of Phenol Derivatives with Umpolung Aldehydes Catalyzed by Nickel
ACS Catal., 2018, 8 (5), pp 4622–4627
DOI: 10.1021/acscatal.8b01224

Design Strategy toward Recyclable and Highly Efficient Heterogeneous Catalysts for the Hydrogenation of CO2 to Formate
Open access through ACS Editors’ Choice
ACS Catal., 2018, 8 (5), pp 4346–4353
DOI: 10.1021/acscatal.8b00392

Engineering Cobalt Defects in Cobalt Oxide for Highly Efficient Electrocatalytic Oxygen Evolution
ACS Catal., 2018, 8 (5), pp 3803–3811
DOI: 10.1021/acscatal.8b01046

Ion Pair-Directed C–H Activation on Flexible Ammonium Salts: meta-Selective Borylation of Quaternized Phenethylamines and Phenylpropylamines
Open access through ACS AuthorChoice
ACS Catal., 2018, 8 (5), pp 3764–3769
DOI: 10.1021/acscatal.8b00423


ACS Combinatorial Science

A Parallel Approach to 7-(Hetero)arylpyrazolo[1,5-a]pyrimidin-5-ones
ACS Comb. Sci., 2018, 20 (5), pp 256–260
DOI: 10.1021/acscombsci.8b00032

Acid-Promoted One-Pot Synthesis of Substituted Furan and 6-Methylpyrazin-2(1H)-one Derivatives via Allene Intermediate Formed in Situ
ACS Comb. Sci., 2018, 20 (5), pp 292–297
DOI: 10.1021/acscombsci.8b00005

Aptamer-Based Paper Strip Sensor for Detecting Vibrio fischeri
ACS Comb. Sci., 2018, 20 (5), pp 261–268
DOI: 10.1021/acscombsci.7b00190

Automated High-Throughput Synthesis of Protein-Loaded Polyanhydride Nanoparticle Libraries
ACS Comb. Sci., 2018, 20 (5), pp 298–307
DOI: 10.1021/acscombsci.8b00008

Construction of Druglike 2-Amido Benzo[d]imidazole Analogues via Desulfurative Cyclization of Thiourea Intermediate Resin on Solid-Phase
ACS Comb. Sci., 2018, 20 (5), pp 282–291
DOI: 10.1021/acscombsci.8b00004


ACS Medicinal Chemistry Letters

2,7-Diazaspiro[4,4]nonanes for the Treatment or Prevention of Cancers and Diabetes
ACS Med. Chem. Lett., 2018, 9 (5), pp 401–402
DOI: 10.1021/acsmedchemlett.8b00159

Academic Drug Development: The DRIVE Model
ACS Med. Chem. Lett., 2018, 9 (5), pp 403–407
DOI: 10.1021/acsmedchemlett.8b00124

Allosteric Modulation of Ionotropic Glutamate Receptors Special Issue
ACS Med. Chem. Lett., 2018, 9 (5), pp 398–399
DOI: 10.1021/acsmedchemlett.8b00174

Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2)
ACS Med. Chem. Lett., 2018, 9 (5), pp 417–421
DOI: 10.1021/acsmedchemlett.7b00427

BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder
ACS Med. Chem. Lett., 2018, 9 (5), pp 472–477
DOI: 10.1021/acsmedchemlett.8b00080


Bioconjugate Chemistry

A Trimethoprim Conjugate of Thiomaltose Has Enhanced Antibacterial Efficacy In Vivo
Bioconjugate Chem., 2018, 29 (5), pp 1729–1735
DOI: 10.1021/acs.bioconjchem.8b00177

Disintegrable NIR Light Triggered Gold Nanorods Supported Liposomal Nanohybrids for Cancer Theranostics
Bioconjugate Chem., 2018, 29 (5), pp 1510–1518
DOI: 10.1021/acs.bioconjchem.7b00801

Fluorescent BODIPY-Anionic Boron Cluster Conjugates as Potential Agents for Cell Tracking
Bioconjugate Chem., 2018, 29 (5), pp 1763–1773
DOI: 10.1021/acs.bioconjchem.8b00204

Highly Sensitive Detection of Caspase-3/7 Activity in Living Mice Using Enzyme-Responsive 19F MRI Nanoprobes
Bioconjugate Chem., 2018, 29 (5), pp 1720–1728
DOI: 10.1021/acs.bioconjchem.8b00167

Investigation on Sugar–Protein Connectivity in Salmonella O-Antigen Glycoconjugate Vaccines
Bioconjugate Chem., 2018, 29 (5), pp 1736–1747
DOI: 10.1021/acs.bioconjchem.8b00178


Inorganic Chemistry

Activation of Co(I) State in a Cobalt-Dithiolato Catalyst for Selective and Efficient CO2 Reduction to CO
Inorg. Chem., 2018, 57 (10), pp 5939–5947
DOI: 10.1021/acs.inorgchem.8b00450

Coordination of Hydrogen Peroxide with Late-Transition-Metal Sulfonamido Complexes
Inorg. Chem., 2018, 57 (9), pp 4841–4848
DOI: 10.1021/acs.inorgchem.7b02514

Earth-Abundant Mixed-Metal Catalysts for Hydrocarbon Oxygenation
Inorg. Chem., 2018, 57 (10), pp 5915–5928
DOI: 10.1021/acs.inorgchem.8b00420

Enhancement of CO2 Uptake and Selectivity in a Metal–Organic Framework by the Incorporation of Thiophene Functionality
Open access through ACS AuthorChoice
Inorg. Chem., 2018, 57 (9), pp 5074–5082
DOI: 10.1021/acs.inorgchem.8b00138

Iron and Cobalt Diazoalkane Complexes Supported by β-Diketiminate Ligands: A Synthetic, Spectroscopic, and Computational Investigation
Inorg. Chem., 2018, 57 (10), pp 5959–5972
DOI: 10.1021/acs.inorgchem.8b00468


Journal of Medicinal Chemistry

A Synthetic Dual Drug Sideromycin Induces Gram-Negative Bacteria To Commit Suicide with a Gram-Positive Antibiotic
J. Med. Chem., 2018, 61 (9), pp 3845–3854
DOI: 10.1021/acs.jmedchem.8b00218

A Trojan-Horse Strategy Including a Bacterial Suicide Action for the Efficient Use of a Specific Gram-Positive Antibiotic on Gram-Negative Bacteria
J. Med. Chem., 2018, 61 (9), pp 3842–3844
DOI: 10.1021/acs.jmedchem.8b00522

Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform
J. Med. Chem., 2018, 61 (10), pp 4335–4347
DOI: 10.1021/acs.jmedchem.7b01698

Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5
J. Med. Chem., 2018, 61 (9), pp 4189–4202
DOI: 10.1021/acs.jmedchem.8b00347

Importance of Rigidity in Designing Small Molecule Drugs To Tackle Protein–Protein Interactions (PPIs) through Stabilization of Desired Conformers
Open access through ACS AuthorChoice
J. Med. Chem., 2018, 61 (10), pp 4283–4289
DOI: 10.1021/acs.jmedchem.7b01120


Journal of Natural Products

ent-Kaurane Diterpenoids with Neuroprotective Properties from Corn Silk (Zea mays)
J. Nat. Prod., 2018, 81 (5), pp 1225–1234
DOI: 10.1021/acs.jnatprod.7b01017

Ajmaline, Oxindole, and Cytotoxic Macroline–Akuammiline Bisindole Alkaloids from Alstonia penangiana
J. Nat. Prod., 2018, 81 (5), pp 1266–1277
DOI: 10.1021/acs.jnatprod.8b00170

Antinociceptive Diterpenoids from the Leaves and Twigs of Rhododendron decorum
J. Nat. Prod., 2018, 81 (5), pp 1183–1192
DOI: 10.1021/acs.jnatprod.7b00941

Antiplasmodial Diterpenoids and a Benzotropolone from Petradoria pumila
J. Nat. Prod., 2018, 81 (5), pp 1260–1265
DOI: 10.1021/acs.jnatprod.8b00135

Bioactivity-Guided Isolation of Potential Antidiabetic and Antihyperlipidemic Compounds from Trigonella stellata
J. Nat. Prod., 2018, 81 (5), pp 1154–1161
DOI: 10.1021/acs.jnatprod.7b00707


The Journal of Organic Chemistry

A General Synthetic Route to Polycyclic Aromatic Dicarboximides by Palladium-Catalyzed Annulation Reaction
Open access through ACS Editors’ Choice
J. Org. Chem., 2018, 83 (10), pp 5339–5346
DOI: 10.1021/acs.joc.8b00301

Enantioselective Synthesis of Thailanstatin A Methyl Ester and Evaluation of in Vitro Splicing Inhibition
J. Org. Chem., 2018, 83 (9), pp 5187–5198
DOI: 10.1021/acs.joc.8b00593

Formal Total Synthesis of Actinoranone: Synthesis Approaches and Cytotoxic Studies
J. Org. Chem., 2018, 83 (9), pp 5160–5176
DOI: 10.1021/acs.joc.8b00514

Improved Substrate Scope in the Potassium Hexacyanoferrate(II)-Based Cyanation for the Synthesis of Benzonitriles and Their Heterocyclic Analogues
J. Org. Chem., 2018, 83 (9), pp 4922–4931
DOI: 10.1021/acs.joc.8b00515

Metal-Oxidant-Free Cobalt-Catalyzed C(sp2)–H Carbonylation of ortho-Arylanilines: An Approach toward Free (NH)-Phenanthridinones
J. Org. Chem., 2018, 83 (10), pp 5698–5706
DOI: 10.1021/acs.joc.8b00730


Molecular Pharmaceutics

A Novel AS1411 Aptamer-Based Three-Way Junction Pocket DNA Nanostructure Loaded with Doxorubicin for Targeting Cancer Cells in Vitro and in Vivo
Mol. Pharmaceutics, 2018, 15 (5), pp 1972–1978
DOI: 10.1021/acs.molpharmaceut.8b00124

Grapefruit Flavonoid Naringenin Regulates the Expression of LXRα in THP-1 Macrophages by Modulating AMP-Activated Protein Kinase
Mol. Pharmaceutics, 2018, 15 (5), pp 1735–1745
DOI: 10.1021/acs.molpharmaceut.7b00797

In Vivo Introduction of mRNA Encapsulated in Lipid Nanoparticles to Brain Neuronal Cells and Astrocytes via Intracerebroventricular Administration
Mol. Pharmaceutics, 2018, 15 (5), pp 2060–2067
DOI: 10.1021/acs.molpharmaceut.7b01084

Iron Oxide Nanoparticles-Based Vaccine Delivery for Cancer Treatment
Mol. Pharmaceutics, 2018, 15 (5), pp 1791–1799
DOI: 10.1021/acs.molpharmaceut.7b01103

Multiple Linear Regression Modeling To Predict the Stability of Polymer–Drug Solid Dispersions: Comparison of the Effects of Polymers and Manufacturing Methods on Solid Dispersion Stability
Mol. Pharmaceutics, 2018, 15 (5), pp 1826–1841
DOI: 10.1021/acs.molpharmaceut.8b00021


Organic Letters

Anthanthrene as a Super-Extended Tetraphenylethylene for Aggregation-Induced Emission
Org. Lett., 2018, 20 (10), pp 2797–2801
DOI: 10.1021/acs.orglett.8b00452

Cascade C(sp3)–S Bond Cleavage and Imidoyl C–S Formation: Radical Cyclization of 2-Isocyanoaryl Thioethers toward 2-Substituted Benzothiazoles
Org. Lett., 2018, 20 (10), pp 3144–3147
DOI: 10.1021/acs.orglett.8b01278

Cross-Coupling of Amides with Alkylboranes via Nickel-Catalyzed C–N Bond Cleavage
Org. Lett., 2018, 20 (10), pp 2976–2979
DOI: 10.1021/acs.orglett.8b01021

Halogenation through Deoxygenation of Alcohols and Aldehydes
Org. Lett., 2018, 20 (10), pp 3061–3064
DOI: 10.1021/acs.orglett.8b01058

Palladium-Catalyzed Decarbonylative Alkynylation of Amides
Org. Lett., 2018, 20 (9), pp 2741–2744
DOI: 10.1021/acs.orglett.8b00949


Organic Process Research & Development

A Facile Epoxide Aminolysis Promoted by (t-BuO)2Mg and Its Application to the Synthesis of Efinaconazole
Org. Process Res. Dev., 2018, 22 (5), pp 625–632
DOI: 10.1021/acs.oprd.8b00081

A Practical Telescoped Three-Step Sequence for the Preparation of (1R,2R)-2-(4-Bromobenzoyl)cyclohexanecarboxylic Acid: A Key Building Block Used in One of Our Drug Development Projects
Org. Process Res. Dev., 2018, 22 (5), pp 618–624
DOI: 10.1021/acs.oprd.8b00066

Asymmetric Organocatalysis in Drug Development—Highlights of Recent Patent Literature
Org. Process Res. Dev., 2018, 22 (5), pp 574–584
DOI: 10.1021/acs.oprd.8b00096

Lewis Acid-Catalyzed Addition of Benzophenone Imine to Epoxides Enables the Selective Synthesis and Derivatization of Primary 1,2-Amino Alcohols
Org. Process Res. Dev., 2018, 22 (5), pp 641–649
DOI: 10.1021/acs.oprd.8b00133

Palladium-Catalyzed C–O Coupling of a Sterically Hindered Secondary Alcohol with an Aryl Bromide and Significant Purity Upgrade in the API Step
Org. Process Res. Dev., 2018, 22 (5), pp 585–594
DOI: 10.1021/acs.oprd.8b00022



Addition of a B–H Bond across an Amido–Cobalt Bond: CoII–H-Catalyzed Hydroboration of Olefins
Organometallics, 2018, 37 (9), pp 1462–1467
DOI: 10.1021/acs.organomet.8b00114

Boraphosphaalkene Synthesis via Phosphaalkyne Insertion into 9-Borafluorene
Organometallics, 2018, 37 (10), pp 1515–1518
DOI: 10.1021/acs.organomet.8b00248

Chain-Walking Polymerization of Linear Internal Octenes Catalyzed by α-Diimine Nickel Complexes
Organometallics, 2018, 37 (9), pp 1358–1367
DOI: 10.1021/acs.organomet.8b00042

Cobalt-Catalyzed C–H Borylation of Alkyl Arenes and Heteroarenes Including the First Selective Borylations of Secondary Benzylic C–H Bonds
Organometallics, 2018, 37 (10), pp 1567–1574
DOI: 10.1021/acs.organomet.8b00144

Disproportionation Reactions of an Organometallic Ni(I) Amidate Complex: Scope and Mechanistic Investigations
Organometallics, 2018, 37 (9), pp 1392–1399
DOI: 10.1021/acs.organomet.8b00074


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