Discover the Most-Read Biological Chemistry Articles of July 2018

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in July 2018, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of July’s most-read articles: Analytical | Applied | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical
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ACS Biomaterials Science & Engineering

Toxicity of Nanomaterials: Exposure, Pathways, Assessment, and Recent Advances
ACS Biomater. Sci. Eng., 2018, 4 (7), pp 2237–2275
DOI: 10.1021/acsbiomaterials.8b00068

Click Chemistry and Material Selection for in Situ Fabrication of Hydrogels in Tissue Engineering Applications
ACS Biomater. Sci. Eng., 2018, 4 (7), pp 2276–2291
DOI: 10.1021/acsbiomaterials.8b00230

Pulsatile Chemotherapeutic Delivery Profiles Using Magnetically Responsive Hydrogels
Open access through ACS Editors’ Choice
ACS Biomater. Sci. Eng., 2018, 4 (7), pp 2412–2423
DOI: 10.1021/acsbiomaterials.8b00348

Engineering Adhesive and Antimicrobial Hyaluronic Acid/Elastin-like Polypeptide Hybrid Hydrogels for Tissue Engineering Applications
ACS Biomater. Sci. Eng., 2018, 4 (7), pp 2528–2540
DOI: 10.1021/acsbiomaterials.8b00408

Transition Metal Ion (Mn2+, Fe2+, Co2+, and Ni2+)-Doped Carbon Dots Synthesized via Microwave-Assisted Pyrolysis: A Potential Nanoprobe for Magneto-fluorescent Dual-Modality Bioimaging
ACS Biomater. Sci. Eng., 2018, 4 (7), pp 2582–2596
DOI: 10.1021/acsbiomaterials.7b00943

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ACS Catalysis

Self-Supported Earth-Abundant Nanoarrays as Efficient and Robust Electrocatalysts for Energy-Related Reactions
ACS Catal., 2018, 8 (7), pp 6707–6732
DOI: 10.1021/acscatal.8b01715

Low-Temperature CO2 Methanation over CeO2-Supported Ru Single Atoms, Nanoclusters, and Nanoparticles Competitively Tuned by Strong Metal–Support Interactions and H-Spillover Effect
ACS Catal., 2018, 8 (7), pp 6203–6215
DOI: 10.1021/acscatal.7b04469

Standards and Protocols for Data Acquisition and Reporting for Studies of the Electrochemical Reduction of Carbon Dioxide
ACS Catal., 2018, 8 (7), pp 6560–6570
DOI: 10.1021/acscatal.8b01340

Visible Light Mediated, Redox Neutral Remote 1,6-Difunctionalizations of Alkenes
ACS Catal., 2018, 8 (7), pp 6401–6406
DOI: 10.1021/acscatal.8b00707

Visible-Light-Mediated Efficient Metal-Free Catalyst for α-Oxygenation of Tertiary Amines to Amides
ACS Catal., 2018, 8 (7), pp 6659–6664
DOI: 10.1021/acscatal.8b01897

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ACS Chemical Biology

In Memoriam: Roger Tsien (1952—2016)
This article is part of the Sensors special issue.
ACS Chem. Biol., 2018, 13 (7), pp 1700–1704
DOI: 10.1021/acschembio.8b00617

Enzyme-Activated Fluorogenic Probes for Live-Cell and in Vivo Imaging
This article is part of the Sensors special issue.
ACS Chem. Biol., 2018, 13 (7), pp 1810–1823
DOI: 10.1021/acschembio.8b00371

Fluorescent Probes of DNA Repair
This article is part of the Sensors special issue.
ACS Chem. Biol., 2018, 13 (7), pp 1721–1733
DOI: 10.1021/acschembio.7b00919

Fluorescent Chemosensors as Future Tools for Cancer Biology
This article is part of the Sensors special issue.
ACS Chem. Biol., 2018, 13 (7), pp 1785–1798
DOI: 10.1021/acschembio.8b00014

Special Issue on Sensors in Biology
This article is part of the Sensors special issue.
ACS Chem. Biol., 2018, 13 (7), pp 1695–1696
DOI: 10.1021/acschembio.8b00593

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ACS Chemical Neuroscience

2018: A New Impact Factor and an Expanded Cast of Associate Editors
ACS Chem. Neurosci., 2018, 9 (7), pp 1517–1517
DOI: 10.1021/acschemneuro.8b00318

Different Positron Emission Tomography Tau Tracers Bind to Multiple Binding Sites on the Tau Fibril: Insight from Computational Modeling
Open access through ACS Editors’ Choice
ACS Chem. Neurosci., 2018, 9 (7), pp 1757–1767
DOI: 10.1021/acschemneuro.8b00093

Peptides, Peptidomimetics, and Carbohydrate–Peptide Conjugates as Amyloidogenic Aggregation Inhibitors for Alzheimer’s Disease
ACS Chem. Neurosci., 2018, 9 (7), pp 1530–1551
DOI: 10.1021/acschemneuro.8b00185

Classics in Chemical Neuroscience: Risperidone
ACS Chem. Neurosci., 2018, 9 (7), pp 1520–1529
DOI: 10.1021/acschemneuro.8b00159

New 2017 Data and Statistics for Pharmaceutical Products
ACS Chem. Neurosci., 2018, 9 (7), pp 1518–1519
DOI: 10.1021/acschemneuro.8b00320

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ACS Infectious Diseases

The Therapeutic Pipeline for Pseudomonas aeruginosa Infections
ACS Infect. Dis., 2018, 4 (7), pp 1041–1047
DOI: 10.1021/acsinfecdis.8b00112

Vancomycin Analogue Restores Meropenem Activity against NDM-1 Gram-Negative Pathogens
ACS Infect. Dis., 2018, 4 (7), pp 1093–1101
DOI: 10.1021/acsinfecdis.8b00011

Avoiding Antibiotic Inactivation in Mycobacterium tuberculosis by Rv3406 through Strategic Nucleoside Modification
ACS Infect. Dis., 2018, 4 (7), pp 1102–1113
DOI: 10.1021/acsinfecdis.8b00038

FRET Flow Cytometry-Based High Throughput Screening Assay To Identify Disrupters of Glucose Levels in Trypanosoma brucei
ACS Infect. Dis., 2018, 4 (7), pp 1058–1066
DOI: 10.1021/acsinfecdis.8b00058

Small Molecule Inhibitors of Metabolic Enzymes Repurposed as a New Class of Anthelmintics
ACS Infect. Dis., 2018, 4 (7), pp 1130–1145
DOI: 10.1021/acsinfecdis.8b00090

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ACS Medicinal Chemistry Letters

Drug Discovery: Collaborations between Contract Research Organizations and the Pharmaceutical Industry
ACS Med. Chem. Lett., 2018, 9 (7), pp 581–583
DOI: 10.1021/acsmedchemlett.8b00236

Chemical Strategies for Half-Life Extension of Biopharmaceuticals: Lipidation and Its Alternatives
ACS Med. Chem. Lett., 2018, 9 (7), pp 577–580
DOI: 10.1021/acsmedchemlett.8b00226

First-Time Disclosures of Clinical Candidates
ACS Med. Chem. Lett., 2018, 9 (7), pp 575–575
DOI: 10.1021/acsmedchemlett.8b00207

Emerging Utility of Fluorosulfate Chemical Probes
ACS Med. Chem. Lett., 2018, 9 (7), pp 584–586
DOI: 10.1021/acsmedchemlett.8b00276

MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology
ACS Med. Chem. Lett., 2018, 9 (7), pp 761–767
DOI: 10.1021/acsmedchemlett.8b00220

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ACS Synthetic Biology

De Novo-Designed α-Helical Barrels as Receptors for Small Molecules
ACS Synth. Biol., 2018, 7 (7), pp 1808–1816
DOI: 10.1021/acssynbio.8b00225

Straightforward Delivery of Linearized Double-Stranded DNA Encoding sgRNA and Donor DNA for the Generation of Single Nucleotide Variants Based on the CRISPR/Cas9 System
ACS Synth. Biol., 2018, 7 (7), pp 1651–1659
DOI: 10.1021/acssynbio.7b00345

“Site and Mutation”-Specific Predictions Enable Minimal Directed Evolution Libraries
ACS Synth. Biol., 2018, 7 (7), pp 1730–1741
DOI: 10.1021/acssynbio.7b00359

Synthesizing a Genetic Sensor Based on CRISPR-Cas9 for Specifically Killing p53-Deficient Cancer Cells
ACS Synth. Biol., 2018, 7 (7), pp 1798–1807
DOI: 10.1021/acssynbio.8b00202

Modulation of Intracellular O2 Concentration in Escherichia coli Strains Using Oxygen Consuming Devices
ACS Synth. Biol., 2018, 7 (7), pp 1742–1752
DOI: 10.1021/acssynbio.7b00428

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Biochemistry

Messenger RNA Structure Regulates Translation Initiation: A Mechanism Exploited from Bacteria to Humans
Biochemistry, 2018, 57 (26), pp 3537–3539
DOI: 10.1021/acs.biochem.8b00395

Targeting the C481S Ibrutinib-Resistance Mutation in Bruton’s Tyrosine Kinase Using PROTAC-Mediated Degradation
Biochemistry, 2018, 57 (26), pp 3564–3575
DOI: 10.1021/acs.biochem.8b00391

So Close, yet Sulfur Away: Opening the Nitrogenase Cofactor Structure Creates a Binding Site
Biochemistry, 2018, 57 (26), pp 3540–3541
DOI: 10.1021/acs.biochem.8b00529

The Need for Manuscripts To Include Database Identifiers for Proteins
Biochemistry, 2018, 57 (29), pp 4239–4240
DOI: 10.1021/acs.biochem.8b00705

New Tools Uncover New Functions for Mobile Zinc in the Brain
This article is part of the Molecules and the Brain special issue.
Biochemistry, 2018, 57 (27), pp 3991–3992
DOI: 10.1021/acs.biochem.8b00108

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Bioconjugate Chemistry

Tuning the Diels–Alder Reaction for Bioconjugation to Maleimide Drug-Linkers
Bioconjugate Chem., 2018, 29 (7), pp 2406–2414
DOI: 10.1021/acs.bioconjchem.8b00320

Development of Anti-CD74 Antibody–Drug Conjugates to Target Glucocorticoids to Immune Cells
Bioconjugate Chem., 2018, 29 (7), pp 2357–2369
DOI: 10.1021/acs.bioconjchem.8b00312

Engineering Intravenously Administered Nanoparticles to Reduce Infusion Reaction and Stop Bleeding in a Large Animal Model of Trauma
Bioconjugate Chem., 2018, 29 (7), pp 2436–2447
DOI: 10.1021/acs.bioconjchem.8b00335

Photoprogramming Allostery in Human Serum Albumin
Open access through ACS AuthorChoice
Bioconjugate Chem., 2018, 29 (7), pp 2215–2224
DOI: 10.1021/acs.bioconjchem.8b00184

Mitochondria-Targeting Polydopamine Nanocomposites as Chemophotothermal Therapeutics for Cancer
Bioconjugate Chem., 2018, 29 (7), pp 2415–2425
DOI: 10.1021/acs.bioconjchem.8b00325

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Biomacromolecules

Different-Length Hydrazone Activated Polymers for Plasmid DNA Condensation and Cellular Transfection
Open access through ACS AuthorChoice
Biomacromolecules, 2018, 19 (7), pp 2638–2649
DOI: 10.1021/acs.biomac.8b00252

Antimicrobial and Antifouling Polymeric Agents for Surface Functionalization of Medical Implants
Biomacromolecules, 2018, 19 (7), pp 2805–2811
DOI: 10.1021/acs.biomac.8b00399

Designing Peptide/Graphene Hybrid Hydrogels through Fine-Tuning of Molecular Interactions
Open access through ACS AuthorChoice
Biomacromolecules, 2018, 19 (7), pp 2731–2741
DOI: 10.1021/acs.biomac.8b00333

Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters
Biomacromolecules, 2018, 19 (7), pp 2351–2376
DOI: 10.1021/acs.biomac.8b00517

Single-Chain Glycopolymer Folding via Host–Guest Interactions and Its Unprecedented Effect on DC-SIGN Binding
Open access through ACS AuthorChoice
Biomacromolecules, 2018, 19 (7), pp 3040–3047
DOI: 10.1021/acs.biomac.8b00600

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Journal of Agricultural and Food Chemistry

Yeast Metabolites of Glycated Amino Acids in Beer
Open access through ACS Editors’ Choice
J. Agric. Food Chem., 2018, 66 (28), pp 7451–7460
DOI: 10.1021/acs.jafc.8b01329

Comprehensive Toxic Plants–Phytotoxins Database and Its Application in Assessing Aquatic Micropollution Potential
Open access through ACS Editors’ Choice
J. Agric. Food Chem., 2018, 66 (29), pp 7577–7588
DOI: 10.1021/acs.jafc.8b01639

Ecological Risk Assessment of Nano-enabled Pesticides: A Perspective on Problem Formulation
Open access through ACS AuthorChoice
J. Agric. Food Chem., 2018, 66 (26), pp 6480–6486
DOI: 10.1021/acs.jafc.7b02373

Improvement of Lipid and Glucose Metabolism by Capsiate in Palmitic Acid-Treated HepG2 Cells via Activation of the AMPK/SIRT1 Signaling Pathway
Open access through ACS AuthorChoice
J. Agric. Food Chem., 2018, 66 (26), pp 6772–6781
DOI: 10.1021/acs.jafc.8b01831

Correction to Fish Oil Supplementation Alleviates the Altered Lipid Homeostasis in Blood, Liver, and Adipose Tissues in High-Fat Diet-Fed Rats
J. Agric. Food Chem., 2018, 66 (28), pp 7550–7550
DOI: 10.1021/acs.jafc.8b03242

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Journal of Chemical Theory and Computation

Estimation of Drug-Target Residence Times by τ-Random Acceleration Molecular Dynamics Simulations
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2018, 14 (7), pp 3859–3869
DOI: 10.1021/acs.jctc.8b00230

Psi4NumPy: An Interactive Quantum Chemistry Programming Environment for Reference Implementations and Rapid Development
J. Chem. Theory Comput., 2018, 14 (7), pp 3504–3511
DOI: 10.1021/acs.jctc.8b00286

Protein Folding Free Energy Landscape along the Committor – the Optimal Folding Coordinate
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2018, 14 (7), pp 3418–3427
DOI: 10.1021/acs.jctc.8b00101

Accuracy of TD-DFT Geometries: A Fresh Look
J. Chem. Theory Comput., 2018, 14 (7), pp 3715–3727
DOI: 10.1021/acs.jctc.8b00311

Atomic Energies from a Convolutional Neural Network
J. Chem. Theory Comput., 2018, 14 (7), pp 3933–3942
DOI: 10.1021/acs.jctc.8b00149

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Journal of Medicinal Chemistry

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
J. Med. Chem., 2018, 61 (14), pp 5822–5880
DOI: 10.1021/acs.jmedchem.7b01788

Editorial on First-Time Disclosures of Clinical Candidates
J. Med. Chem., 2018, 61 (13), pp 5449–5449
DOI: 10.1021/acs.jmedchem.8b00739

Design, Synthesis, and Biological Evaluation of Pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation
J. Med. Chem., 2018, 61 (13), pp 5609–5622
DOI: 10.1021/acs.jmedchem.8b00346

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach
J. Med. Chem., 2018, 61 (13), pp 5719–5732
DOI: 10.1021/acs.jmedchem.8b00653

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization
J. Med. Chem., 2018, 61 (13), pp 5525–5546
DOI: 10.1021/acs.jmedchem.8b00011

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Journal of Natural Products

Swinhoeisterols from the South China Sea Sponge Theonella swinhoei
J. Nat. Prod., 2018, 81 (7), pp 1645–1650
DOI: 10.1021/acs.jnatprod.8b00281

Banksialactones and Banksiamarins: Isochromanones and Isocoumarins from an Australian Fungus, Aspergillus banksianus
J. Nat. Prod., 2018, 81 (7), pp 1517–1526
DOI: 10.1021/acs.jnatprod.7b00816

Cytochalasans Produced by the Coculture of Aspergillus flavipes and Chaetomium globosum
J. Nat. Prod., 2018, 81 (7), pp 1578–1587
DOI: 10.1021/acs.jnatprod.8b00110

Linfuranones B and C, Furanone-Containing Polyketides from a Plant-Associated Sphaerimonospora mesophila
J. Nat. Prod., 2018, 81 (7), pp 1561–1569
DOI: 10.1021/acs.jnatprod.8b00071

Abietane Diterpenoids from the Roots of Clerodendrum trichotomum and Their Nitric Oxide Inhibitory Activities
J. Nat. Prod., 2018, 81 (7), pp 1508–1516
DOI: 10.1021/acs.jnatprod.7b00814

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The Journal of Physical Chemistry B

Validating Molecular Dynamics Simulations against Experimental Observables in Light of Underlying Conformational Ensembles
J. Phys. Chem. B, 2018, 122 (26), pp 6673–6689
DOI: 10.1021/acs.jpcb.8b02144

Water’s Interfacial Hydrogen Bonding Structure Reveals the Effective Strength of Surface–Water Interactions
J. Phys. Chem. B, 2018, 122 (26), pp 6781–6789
DOI: 10.1021/acs.jpcb.8b02438

Excited State Decay Pathways of 2′-Deoxy-5-methylcytidine and Deoxycytidine Revisited in Solution: A Comprehensive Kinetic Study by Femtosecond Transient Absorption
J. Phys. Chem. B, 2018, 122 (28), pp 7027–7037
DOI: 10.1021/acs.jpcb.8b00927

Dependence of the Formation of Tau and Aβ Peptide Mixed Aggregates on the Secondary Structure of the N-Terminal Region of Aβ
J. Phys. Chem. B, 2018, 122 (28), pp 7049–7056
DOI: 10.1021/acs.jpcb.8b04647

Molecular Structure and Permeability at the Interface between Phase-Separated Membrane Domains
J. Phys. Chem. B, 2018, 122 (27), pp 6954–6965
DOI: 10.1021/acs.jpcb.8b03406

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The Journal of Physical Chemistry Letters

Hydrogen Bond Length as a Key To Understanding Sweetness
J. Phys. Chem. Lett., 2018, 9 (13), pp 3667–3672
DOI: 10.1021/acs.jpclett.8b01280

Thermodynamics and the Intrinsic Stability of Lead Halide Perovskites CH3NH3PbX3
Open access through ACS Editors’ Choice
J. Phys. Chem. Lett., 2018, 9 (13), pp 3756–3765
DOI: 10.1021/acs.jpclett.8b00463

The Benefit and Challenges of Zero-Dimensional Perovskites
J. Phys. Chem. Lett., 2018, 9 (14), pp 4131–4138
DOI: 10.1021/acs.jpclett.8b00532

Temperature-Dependent Photoluminescence of CH3NH3PbBr3 Perovskite Quantum Dots and Bulk Counterparts
J. Phys. Chem. Lett., 2018, 9 (14), pp 4066–4074
DOI: 10.1021/acs.jpclett.8b01593

Vibrationally Assisted Intersystem Crossing in Benchmark Thermally Activated Delayed Fluorescence Molecules
Open access through ACS AuthorChoice
J. Phys. Chem. Lett., 2018, 9 (14), pp 4053–4058
DOI: 10.1021/acs.jpclett.8b01556

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Journal of Proteome Research

Comparison of In-Solution, FASP, and S-Trap Based Digestion Methods for Bottom-Up Proteomic Studies
J. Proteome Res., 2018, 17 (7), pp 2480–2490
DOI: 10.1021/acs.jproteome.8b00235

Quantitative Assessment of Urea In-Solution Lys-C/Trypsin Digestions Reveals Superior Performance at Room Temperature over Traditional Proteolysis at 37 °C
J. Proteome Res., 2018, 17 (7), pp 2556–2561
DOI: 10.1021/acs.jproteome.8b00228

IdentiPy: An Extensible Search Engine for Protein Identification in Shotgun Proteomics
J. Proteome Res., 2018, 17 (7), pp 2249–2255
DOI: 10.1021/acs.jproteome.7b00640

MALDI Imaging Analysis of Neuropeptides in Africanized Honeybee (Apis mellifera) Brain: Effect of Aggressiveness
J. Proteome Res., 2018, 17 (7), pp 2358–2369
DOI: 10.1021/acs.jproteome.8b00098

Identification of MS-Cleavable and Noncleavable Chemically Cross-Linked Peptides with MetaMorpheus
J. Proteome Res., 2018, 17 (7), pp 2370–2376
DOI: 10.1021/acs.jproteome.8b00141

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Molecular Pharmaceutics

Hybrid Mesoporous–Microporous Nanocarriers for Overcoming Multidrug Resistance by Sequential Drug Delivery
Mol. Pharmaceutics, 2018, 15 (7), pp 2503–2512
DOI: 10.1021/acs.molpharmaceut.7b01096

Probing the Interplay between Amorphous Solid Dispersion Stability and Polymer Functionality
Mol. Pharmaceutics, 2018, 15 (7), pp 2714–2720
DOI: 10.1021/acs.molpharmaceut.8b00219

Near-Infrared Activatable Phthalocyanine–Poly-L-Glutamic Acid Conjugate: Enhanced in Vivo Safety and Antitumor Efficacy toward an Effective Photodynamic Cancer Therapy
Mol. Pharmaceutics, 2018, 15 (7), pp 2594–2605
DOI: 10.1021/acs.molpharmaceut.8b00132

Entrapping of Nanoparticles in Yeast Cell Wall Microparticles for Macrophage-Targeted Oral Delivery of Cabazitaxel
Mol. Pharmaceutics, 2018, 15 (7), pp 2870–2882
DOI: 10.1021/acs.molpharmaceut.8b00357

Novel Milrinone Nanoformulation for Use in Cardiovascular Diseases: Preparation and in Vitro Characterization
Mol. Pharmaceutics, 2018, 15 (7), pp 2489–2502
DOI: 10.1021/acs.molpharmaceut.7b00360

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