Discover the Most-Read Biological Chemistry Articles of August 2018

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in August 2018, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

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Read more of August’s most-read articles: Analytical | Applied | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical

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ACS Biomaterials Science & Engineering

Biomedical Applications of Graphene Nanomaterials and Beyond
ACS Biomater. Sci. Eng., 2018, 4 (8), pp 2653–2703
DOI: 10.1021/acsbiomaterials.8b00376

Thermoresponsive Citrate-Based Graphene Oxide Scaffold Enhances Bone Regeneration from BMP9-Stimulated Adipose-Derived Mesenchymal Stem Cells
Open access through ACS AuthorChoice
ACS Biomater. Sci. Eng., 2018, 4 (8), pp 2943–2955
DOI: 10.1021/acsbiomaterials.8b00179

Retraction of “Assessment of an Integrative Anticancer Treatment Using an in Vitro Perfusion-Enabled 3D Breast Tumor Model”
ACS Biomater. Sci. Eng., 2018, 4 (8), pp 3107–3107
DOI: 10.1021/acsbiomaterials.8b00698

3D Printing of Silk Particle-Reinforced Chitosan Hydrogel Structures and Their Properties
ACS Biomater. Sci. Eng., 2018, 4 (8), pp 3036–3046
DOI: 10.1021/acsbiomaterials.8b00804

Advanced Silk Fibroin Biomaterials for Cartilage Regeneration
ACS Biomater. Sci. Eng., 2018, 4 (8), pp 2704–2715
DOI: 10.1021/acsbiomaterials.8b00150

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ACS Catalysis

Single-Atomic Cu with Multiple Oxygen Vacancies on Ceria for Electrocatalytic CO2 Reduction to CH4
ACS Catal., 2018, 8 (8), pp 7113–7119
DOI: 10.1021/acscatal.8b01014

Electrocatalytic C–H Activation
ACS Catal., 2018, 8 (8), pp 7086–7103
DOI: 10.1021/acscatal.8b01682

Approaches for Understanding and Controlling Interfacial Effects in Oxide-Supported Metal Catalysts
ACS Catal., 2018, 8 (8), pp 7368–7387
DOI: 10.1021/acscatal.8b02071

Gold-Catalyzed Oxidative Coupling of Terminal Alkynes and Borane Adducts: Efficient Synthesis of α-Boryl Ketones
Open access through ACS Editors’ Choice
ACS Catal., 2018, 8 (8), pp 7351–7355
DOI: 10.1021/acscatal.8b02052

Bisphosphines: A Prominent Ancillary Ligand Class for Application in Nickel-Catalyzed C–N Cross-Coupling
ACS Catal., 2018, 8 (8), pp 7228–7250
DOI: 10.1021/acscatal.8b01879

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ACS Chemical Biology

Introducing Our Authors
ACS Chem. Biol., 2018, 13 (8), pp 1909–1913
DOI: 10.1021/acschembio.8b00710

Lipidomics Suggests a New Role for Ceramide Synthase in Phagocytosis
Open access through ACS AuthorChoice
ACS Chem. Biol., 2018, 13 (8), pp 2280–2287
DOI: 10.1021/acschembio.8b00438

Human Milk Oligosaccharides (HMOs) Sensitize Group B Streptococcus to Clindamycin, Erythromycin, Gentamicin, and Minocycline on a Strain Specific Basis
ACS Chem. Biol., 2018, 13 (8), pp 2020–2026
DOI: 10.1021/acschembio.8b00661

Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target
ACS Chem. Biol., 2018, 13 (8), pp 1970–1977
DOI: 10.1021/acschembio.8b00381

Screening a Protein Array with Synthetic Biotinylated Inorganic Polyphosphate To Define the Human PolyP-ome
Open access through ACS Editors’ Choice
ACS Chem. Biol., 2018, 13 (8), pp 1958–1963
DOI: 10.1021/acschembio.8b00357

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ACS Chemical Neuroscience

Animal Model Systems in Neuroscience
This article is part of the Model Systems in Neuroscience special issue.
ACS Chem. Neurosci., 2018, 9 (8), pp 1869–1870
DOI: 10.1021/acschemneuro.8b00380

Bad Behavior: Improving Reproducibility in Behavior Testing
This article is part of the Model Systems in Neuroscience special issue.
ACS Chem. Neurosci., 2018, 9 (8), pp 1904–1906
DOI: 10.1021/acschemneuro.7b00504

Drosophila as a Model System for Neurotransmitter Measurements
This article is part of the Model Systems in Neuroscience special issue.
ACS Chem. Neurosci., 2018, 9 (8), pp 1872–1883
DOI: 10.1021/acschemneuro.7b00456

Melatonin Improves Cognitive Deficits via Restoration of Cholinergic Dysfunction in a Mouse Model of Scopolamine-Induced Amnesia
This article is part of the Model Systems in Neuroscience special issue.
ACS Chem. Neurosci.,
2018, 9 (8), pp 2016–2024
DOI: 10.1021/acschemneuro.7b00278

From Cultured Rodent Neurons to Human Brain Tissue: Model Systems for Pharmacological and Translational Neuroscience
ACS Chem. Neurosci., 2018, 9 (8), pp 1975–1985
DOI: 10.1021/acschemneuro.8b00098

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ACS Infectious Diseases

In Vitro Model of the Gram-Negative Bacterial Cell Envelope for Investigation of Anti-Infective Permeation Kinetics
ACS Infect. Dis., 2018, 4 (8), pp 1188–1196
DOI: 10.1021/acsinfecdis.7b00165

Molecular Properties That Define the Activities of Antibiotics in Escherichia coli and Pseudomonas aeruginosa
ACS Infect. Dis., 2018, 4 (8), pp 1223–1234
DOI: 10.1021/acsinfecdis.8b00036

A Comparison of Optical, Electrochemical, Magnetic, and Colorimetric Point-of-Care Biosensors for Infectious Disease Diagnosis
ACS Infect. Dis., 2018, 4 (8), pp 1162–1178
DOI: 10.1021/acsinfecdis.8b00023

Evaluation of Current and Emerging Antimalarial Medicines for Inhibition of Toxoplasma gondii Growth in Vitro
ACS Infect. Dis., 2018, 4 (8), pp 1264–1274
DOI: 10.1021/acsinfecdis.8b00113

Magnetic Glycol Chitin-Based Hydrogel Nanocomposite for Combined Thermal and d-Amino-Acid-Assisted Biofilm Disruption
ACS Infect. Dis., 2018, 4 (8), pp 1246–1256
DOI: 10.1021/acsinfecdis.8b00076

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ACS Medicinal Chemistry Letters

Investigating the Behavior of Published PAINS Alerts Using a Pharmaceutical Company Data Set
Open access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2018, 9 (8), pp 792–796
DOI: 10.1021/acsmedchemlett.8b00097

C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer?
ACS Med. Chem. Lett., 2018, 9 (8), pp 779–782
DOI: 10.1021/acsmedchemlett.8b00314

New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons
ACS Med. Chem. Lett., 2018, 9 (8), pp 803–808
DOI: 10.1021/acsmedchemlett.8b00106

Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody–Drug Conjugates
Open access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2018, 9 (8), pp 838–842
DOI: 10.1021/acsmedchemlett.8b00254

Allosteric Modulators of the M4 Muscarinic Acetylcholine Receptor
ACS Med. Chem. Lett., 2018, 9 (8), pp 783–784
DOI: 10.1021/acsmedchemlett.8b00330

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ACS Synthetic Biology

Predicting Transcriptional Output of Synthetic Multi-input Promoters
ACS Synth. Biol., 2018, 7 (8), pp 1834–1843
DOI: 10.1021/acssynbio.8b00165

Synthetic Pathway for the Production of Olivetolic Acid in Escherichia coli
ACS Synth. Biol., 2018, 7 (8), pp 1886–1896
DOI: 10.1021/acssynbio.8b00075

An Engineered Constitutive Promoter Set with Broad Activity Range for Cupriavidus necator H16
Open access through ACS AuthorChoice
ACS Synth. Biol., 2018, 7 (8), pp 1918–1928
DOI: 10.1021/acssynbio.8b00136

Sequence Specific Modeling of E. coli Cell-Free Protein Synthesis
ACS Synth. Biol.,2018, 7 (8), pp 1844–1857
DOI: 10.1021/acssynbio.7b00465

Electric-Field Manipulation of a Compartmentalized Cell-Free Gene Expression Reaction
ACS Synth. Biol.,2018, 7 (8), pp 1829–1833
DOI: 10.1021/acssynbio.8b00160

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Biochemistry

Revealing Unexplored Sequence-Function Space Using Sequence Similarity Networks
This article is part of the Discovering New Tools special issue.
Biochemistry, 2018, 57 (31), pp 4651–4662
DOI: 10.1021/acs.biochem.8b00473

Conformational Switching of the Nuclear Exosome during Ribosome Biogenesis
Biochemistry, 2018, 57 (32), pp 4765–4766
DOI: 10.1021/acs.biochem.8b00593

Conformational Switching of the Nuclear Exosome during Ribosome Biogenesis
Open access through ACS AuthorChoice
Biochemistry, 2018, 57 (32), pp 4765–4766
DOI: 10.1021/acs.biochem.8b00593

A Bifunctional Noncanonical Amino Acid: Synthesis, Expression, and Residue-Specific Proteome-wide Incorporation
This article is part of the Discovering New Tools special issue.
Biochemistry, 2018, 57 (31), pp 4747–4752
DOI: 10.1021/acs.biochem.8b00397

Measuring RNA–Ligand Interactions with Microscale Thermophoresis
This article is part of the Discovering New Tools special issue.
Biochemistry, 2018, 57 (31), pp 4638–4643
DOI: 10.1021/acs.biochem.7b01141

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Bioconjugate Chemistry

Covalent Modification of Biomolecules through Maleimide-Based Labeling Strategies
Bioconjugate Chem., 2018, 29 (8), pp 2497–2513
DOI: 10.1021/acs.bioconjchem.8b00252

“Tag and Modify” Protein Conjugation with Dynamic Covalent Chemistry
Bioconjugate Chem., 2018, 29 (8), pp 2665–2670
DOI: 10.1021/acs.bioconjchem.8b00358

Rational Design and Bioimaging Applications of Highly Specific “Turn-On” Fluorescent Probe for Hypochlorite
Bioconjugate Chem., 2018, 29 (8), pp 2838–2845
DOI: 10.1021/acs.bioconjchem.8b00430

Click Chemistry-Based DNA Labeling of Cells for Barcoding Applications
Bioconjugate Chem., 2018, 29 (8), pp 2846–2854
DOI: 10.1021/acs.bioconjchem.8b00435

Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue
Bioconjugate Chem., 2018, 29 (8), pp 2741–2754
DOI: 10.1021/acs.bioconjchem.8b00386

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Biomacromolecules

Polymers at the Interface with Biology
Biomacromolecules, 2018, 19 (8), pp 3151–3162
DOI: 10.1021/acs.biomac.8b01029

Ice Recrystallization Inhibiting Polymers Enable Glycerol-Free Cryopreservation of Microorganisms
Open access through ACS AuthorChoice
Biomacromolecules, 2018, 19 (8), pp 3371–3376
DOI: 10.1021/acs.biomac.8b00660

Bioinspired pH- and Temperature-Responsive Injectable Adhesive Hydrogels with Polyplexes Promotes Skin Wound Healing
Biomacromolecules, 2018, 19 (8), pp 3536–3548
DOI: 10.1021/acs.biomac.8b00819

Construction of Small-Sized, Robust, and Reduction-Responsive Polypeptide Micelles for High Loading and Targeted Delivery of Chemotherapeutics
Biomacromolecules, 2018, 19 (8), pp 3586–3593
DOI: 10.1021/acs.biomac.8b00835

Evaluation of Amphiphilic Star/Linear–Dendritic Polymer Reverse Micelles for Transdermal Drug Delivery: Directing Carrier Properties by Tailoring Core versus Peripheral Branching
Biomacromolecules, 2018, 19 (8), pp 3163–3176
DOI: 10.1021/acs.biomac.8b00680

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Journal of Agricultural and Food Chemistry

Saliva and Flavor Perception: Perspectives
J. Agric. Food Chem., 2018, 66 (30), pp 7873–7879
DOI: 10.1021/acs.jafc.8b01998

Interaction of Polyphenols with Other Food Components as a Means for Their Neurological Health Benefits
J. Agric. Food Chem., 2018, 66 (31), pp 8224–8230
DOI: 10.1021/acs.jafc.8b02839

Design, Synthesis, and Biological Activity of β-Carboline Analogues Containing Hydantoin, Thiohydantoin, and Urea Moieties
J. Agric. Food Chem., 2018, 66 (31), pp 8253–8261
DOI: 10.1021/acs.jafc.8b03087

Green and Black Tea Phenolics: Bioavailability, Transformation by Colonic Microbiota, and Modulation of Colonic Microbiota
J. Agric. Food Chem., 2018, 66 (32), pp 8469–8477
DOI: 10.1021/acs.jafc.8b02233

Gold Standards for Realistic (Poly)phenol Research
J. Agric. Food Chem., 2018, 66 (31), pp 8221–8223
DOI: 10.1021/acs.jafc.8b03249

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Journal of Chemical Theory and Computation

Machine Learning Adaptive Basis Sets for Efficient Large Scale Density Functional Theory Simulation
Open access through ACS Editors’ Choice
J. Chem. Theory Comput., 2018, 14 (8), pp 4168–4175
DOI: 10.1021/acs.jctc.8b00378

High-Throughput Screening Approach for Nanoporous Materials Genome Using Topological Data Analysis: Application to Zeolites
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2018, 14 (8), pp 4427–4437
DOI: 10.1021/acs.jctc.8b00253

Predicting Pathways between Distant Configurations for Biomolecules
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2018, 14 (8), pp 4271–4278
DOI: 10.1021/acs.jctc.8b00370

Double Precision Is Not Needed for Many-Body Calculations: Emergent Conventional Wisdom
J. Chem. Theory Comput., 2018, 14 (8), pp 4088–4096
DOI: 10.1021/acs.jctc.8b00321

Optimization of the Linear-Scaling Local Natural Orbital CCSD(T) Method: Improved Algorithm and Benchmark Applications
J. Chem. Theory Comput., 2018, 14 (8), pp 4193–4215
DOI: 10.1021/acs.jctc.8b00442

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Journal of Medicinal Chemistry

Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)
J. Med. Chem., 2018, 61 (15), pp 6501–6517
DOI: 10.1021/acs.jmedchem.8b00741

Lipophilic Efficiency as an Important Metric in Drug Design
J. Med. Chem., 2018, 61 (15), pp 6401–6420
DOI: 10.1021/acs.jmedchem.8b00077

Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations
J. Med. Chem., 2018, 61 (15), pp 6421–6467
DOI: 10.1021/acs.jmedchem.8b00180

Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression
J. Med. Chem., 2018, 61 (15), pp 6685–6704
DOI: 10.1021/acs.jmedchem.8b00506

Synthetic Approaches to New Drugs Approved During 2016
J. Med. Chem., 2018, 61 (16), pp 7004–7031
DOI: 10.1021/acs.jmedchem.8b00260

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Journal of Natural Products

An Alkaloid from Scorpion Venom: Chemical Structure and Synthesis
J. Nat. Prod., 2018, 81 (8), pp 1899–1904
DOI: 10.1021/acs.jnatprod.8b00527

A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera
J. Nat. Prod., 2018, 81 (8), pp 1693–1700
DOI: 10.1021/acs.jnatprod.7b00892

Antitumor Activity of Diterpenoids from Jatropha gossypiifolia: Cell Cycle Arrest and Apoptosis-Inducing Activity in RKO Colon Cancer Cells
J. Nat. Prod., 2018, 81 (8), pp 1701–1710
DOI: 10.1021/acs.jnatprod.7b01036

Anti-inflammatory Potential of Flavonoids from the Aerial Parts of Corispermum marschallii
J. Nat. Prod., 2018, 81 (8), pp 1760–1768
DOI: 10.1021/acs.jnatprod.8b00152

Bioactive Sesquiterpenoids from the Peeled Stems of Syringa pinnatifolia
J. Nat. Prod., 2018, 81 (8), pp 1711–1720
DOI: 10.1021/acs.jnatprod.7b01071

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The Journal of Physical Chemistry B

Phase Diagrams of TIP4P/2005, SPC/E, and TIP5P Water at High Pressure
J. Phys. Chem. B, 2018, 122 (31), pp 7718–7725
DOI: 10.1021/acs.jpcb.8b04441

X-ray Scattering and O–O Pair-Distribution Functions of Amorphous Ices
Open access through ACS AuthorChoice
J. Phys. Chem. B, 2018, 122 (30), pp 7616–7624
DOI: 10.1021/acs.jpcb.8b04823

Effects of Non-native Interactions on Frustrated Proteins Folding under Confinement
J. Phys. Chem. B, 2018, 122 (31), pp 7654–7667
DOI: 10.1021/acs.jpcb.8b04147

Cooling of Pure Water at Room Temperature by Weak Electric Currents
J. Phys. Chem. B, 2018, 122 (31), pp 7711–7717
DOI: 10.1021/acs.jpcb.7b12689

Simulation of Mixed Self-Assembled Monolayers on Gold: Effect of Terminal Alkyl Anchor Chain and Monolayer Composition
J. Phys. Chem. B, 2018, 122 (31), pp 7699–7710
DOI: 10.1021/acs.jpcb.8b05075

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The Journal of Physical Chemistry Letters

Electronic Preresonance Stimulated Raman Scattering Microscopy
Open access through ACS Editors’ Choice
J. Phys. Chem. Lett., 2018, 9 (15), pp 4294–4301
DOI: 10.1021/acs.jpclett.8b00204

Perovskite Solar Cells: Toward Industrial-Scale Methods
J. Phys. Chem. Lett., 2018, 9 (15), pp 4326–4335
DOI: 10.1021/acs.jpclett.8b01356

Atomic Layer Etching: Rethinking the Art of Etch
Open access through ACS AuthorChoice
J. Phys. Chem. Lett., 2018, 9 (16), pp 4814–4821
DOI: 10.1021/acs.jpclett.8b00997

Crystal Phases and Thermal Stability of Co-evaporated CsPbX3 (X = I, Br) Thin Films
J. Phys. Chem. Lett., 2018, 9 (16), pp 4808–4813
DOI: 10.1021/acs.jpclett.8b02059

Achieving Efficient Triplet Exciton Utilization with Large ΔEST and Nonobvious Delayed Fluorescence by Adjusting Excited State Energy Levels
J. Phys. Chem. Lett., 2018, 9 (16), pp 4725–4731
DOI: 10.1021/acs.jpclett.8b01961

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Journal of Proteome Research

Transformative Opportunities for Single-Cell Proteomics
J. Proteome Res., 2018, 17 (8), pp 2565–2571
DOI: 10.1021/acs.jproteome.8b00257

CharmeRT: Boosting Peptide Identifications by Chimeric Spectra Identification and Retention Time Prediction
Open access through ACS AuthorChoice
J. Proteome Res., 2018, 17 (8), pp 2581–2589
DOI: 10.1021/acs.jproteome.7b00836

Affimers as an Alternative to Antibodies in an Affinity LC–MS Assay for Quantification of the Soluble Receptor of Advanced Glycation End-Products (sRAGE) in Human Serum
Open access through ACS AuthorChoice
J. Proteome Res., 2018, 17 (8), pp 2892–2899
DOI: 10.1021/acs.jproteome.8b00414

Innovations in Proteomics: The Drive to Single Cells
J. Proteome Res., 2018, 17 (8), pp 2563–2564
DOI: 10.1021/acs.jproteome.8b00484

Similar Albeit Not the Same: In-Depth Analysis of Proteoforms of Human Serum, Bovine Serum, and Recombinant Human Fetuin
J. Proteome Res., 2018, 17 (8), pp 2861–2869
DOI: 10.1021/acs.jproteome.8b00318

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Molecular Pharmaceutics

“Click” Chemistry for Medicine and Biology
This article is part of the Click Chemistry for Medicine and Biology special issue.
Mol. Pharmaceutics, 2018, 15 (8), pp 2891–2891
DOI: 10.1021/acs.molpharmaceut.8b00743

Interactions of Artefenomel (OZ439) with Milk during Digestion: Insights into Digestion-Driven Solubilization and Polymorphic Transformations
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (8), pp 3535–3544
DOI: 10.1021/acs.molpharmaceut.8b00541

Bacterial Cytological Profiling Reveals the Mechanism of Action of Anticancer Metal Complexes
Mol. Pharmaceutics, 2018, 15 (8), pp 3404–3416
DOI: 10.1021/acs.molpharmaceut.8b00407

Bioinspired Shielding Strategies for Nanoparticle Drug Delivery Applications
This article is part of the Click Chemistry for Medicine and Biology special issue.
Mol. Pharmaceutics, 2018, 15 (8), pp 2900–2909
DOI: 10.1021/acs.molpharmaceut.8b00292

Methionine-Decorated Near Infrared Fluorescent Probe for Prolonged Tumor Imaging
Mol. Pharmaceutics, 2018, 15 (8), pp 3167–3176
DOI: 10.1021/acs.molpharmaceut.8b00233
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