ACS Editors’ Choice: New treatments for Hepatitis C

ACS Editors’ Choice: Developing New Treatments for Hepatitis C, Improving Biorefineries — and More!

This week: fighting Hepatitis C with derivatives from an over-the-counter antihistamine, a process that could improve the economic viability of modern biorefineries, a look at fetal exposure to antidepressants in mice – and more!

Each and every day, ACS grants free access to a new peer-reviewed research article from one of the Society’s journals. These articles are specially chosen by a team of scientific editors of ACS journals from around the world to highlight the transformative power of chemistry. Access to these articles will remain open to all as a public service.

Check out this week’s picks!

Maternal Pharmacokinetics and Fetal Disposition of (±)-Citalopram during Mouse Pregnancy


Juan C. Velasquez, Nick Goeden, Skyla M. Herod, and Alexandre Bonnin

ACS Chem. Neurosci., Article ASAP

DOI: 10.1021/acschemneuro.5b00287


Isolation and Structural Characterization of a Mackay 55-Metal-Atom Two-Shell Icosahedron of Pseudo-Ih Symmetry, Pd55L123-CO)20 (L = PR3, R = Isopropyl): Comparative Analysis with Interior Two-Shell Icosahedral Geometries in Capped Three-Shell Pd145, Pt-Centered Four-Shell Pd–Pt M165, and Four-Shell Au133 Nanoclusters


Jeremiah D. Erickson, Evgueni G. Mednikov, Sergei A. Ivanov, and Lawrence F. Dahl

Am. Chem. Soc., Article ASAP

DOI: 10.1021/jacs.5b13076


Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection

 Hepatitis C

Shanshan He, Jingbo Xiao, Andrés E. Dulcey, Billy Lin, Adam Rolt, Zongyi Hu, Xin Hu, Amy Q. Wang, Xin Xu, Noel Southall, Marc Ferrer, Wei Zheng, T. Jake Liang, and Juan J. Marugan

Med. Chem., Article ASAP

DOI: 10.1021/acs.jmedchem.5b00752


Prebiotic NH3 Formation: Insights from Simulations


András Stirling, Tamás Rozgonyi, Matthias Krack, and Marco Bernasconi

Inorg. Chem., Article ASAP

DOI: 10.1021/acs.inorgchem.5b02911


A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo


Maruti Uppalapati, Dong Jun Lee, Kalyaneswar Mandal, Hongyan Li§, Les P. Miranda, Joshua Lowitz, John Kenney, Jarrett J. Adams, Dana Ault-Riché#, Stephen B. H. Kent, and Sachdev S. Sidhu

ACS Chem. Biol., Article ASAP

DOI: 10.1021/acschembio.5b01006


Catalytic H2O2 Disproportionation and Electrocatalytic O2 Reduction by a Functional Mimic of Heme Catalase: Direct Observation of Compound 0 and Compound I in Situ


Kushal Sengupta, Sudipta Chatterjee, and Abhishek Dey

ACS Catal., 2016, 6, pp 1382–1388

DOI: 10.1021/acscatal.5b02668


Base-Catalyzed Depolymerization of Biorefinery Lignins


Rui Katahira, Ashutosh Mittal, Kellene McKinney, Xiaowen Chen, Melvin P. Tucker, David K. Johnson, and Gregg T. Beckham

ACS Sustainable Chem. Eng., Article ASAP

DOI: 10.1021/acssuschemeng.5b01451


Love ACS Editors’ Choice? Get a weekly e-mail of the latest ACS Editor’s Choice articles and never miss a breakthrough!




Want more stories like this delivered to your inbox?

Sign up for our newsletter to receive a selection of stories related to your favorite topics.

  • This field is for validation purposes and should be left unchanged.