Discover the Most-Read Biological Chemistry Articles of Feb. 2017

What were chemists reading in February of 2017? To find out, we’ve compiled lists of the five most-read biological chemistry articles that appeared in relevant ACS Publications journals in February 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.
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ACS Biomaterials Science & Engineering

Editorial: Special Issue on Biomaterials for Immunoengineering
ACS Biomater. Sci. Eng., 2017, 3 (2), pp 106–107
DOI: 10.1021/acsbiomaterials.7b00049

Polymers for DNA Vaccine Delivery
ACS Biomater. Sci. Eng., 2017, 3 (2), pp 108–125
DOI: 10.1021/acsbiomaterials.6b00418

In Vivo Expansion of Melanoma-Specific T Cells Using Microneedle Arrays Coated with Immune-Polyelectrolyte Multilayers
ACS Biomater. Sci. Eng., 2017, 3 (2), pp 195–205
DOI: 10.1021/acsbiomaterials.6b00414

Surface Coating of Nanoparticles Reduces Background Inflammatory Activity while Increasing Particle Uptake and Delivery
ACS Biomater. Sci. Eng., 2017, 3 (2), pp 206–213
DOI: 10.1021/acsbiomaterials.6b00473

Biomaterials-Based Vaccination Strategies for the Induction of CD8+T Cell Responses
This article is part of the Biomaterials for Immunoengineering special issue.
ACS Biomater. Sci. Eng., 2017, 3 (2), pp 126–143
DOI: 10.1021/acsbiomaterials.6b00412

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ACS Catalysis

A Versatile Disulfide-Driven Recycling System for NADP+ with High Cofactor Turnover Number
Open access through ACS Editors’ Choice
ACS Catal., 2017, 7 (2), pp 1025–1029
DOI: 10.1021/acscatal.6b03061

Visible-Light-Mediated Anti-Markovnikov Hydration of Olefins
Open access through ACS Editors’ Choice
ACS Catal., 2017, 7 (2), pp 1432–1437
DOI: 10.1021/acscatal.6b03388

Breaking Amides using Nickel Catalysis
ACS Catal., 2017, 7 (2), pp 1413–1423
DOI: 10.1021/acscatal.6b03277

Metal–Metal Bonds in Catalysis
ACS Catal., 2017, 7 (2), pp 936–958
DOI: 10.1021/acscatal.6b02692

Catalytic Zirconium/Hafnium-Based Metal–Organic Frameworks
ACS Catal., 2017, 7 (2), pp 997–1014
DOI: 10.1021/acscatal.6b02923

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ACS Chemical Biology

Chemical Modifications to RNA: A New Layer of Gene Expression Regulation
ACS Chem. Biol., 2017, 12 (2), pp 316–325
DOI: 10.1021/acschembio.6b00960

Deciphering the Functions of Protein O-GlcNAcylation with Chemistry
ACS Chem. Biol., 2017, 12 (2), pp 326–335
DOI: 10.1021/acschembio.6b01065

Duration Control of Protein Expression in Vivo by Light-Mediated Reversible Activation of Translation
ACS Chem. Biol., 2017, 12 (2), pp 351–356
DOI: 10.1021/acschembio.6b00684

Engineering High Affinity Protein–Protein Interactions Using a High-Throughput Microcapillary Array Platform
ACS Chem. Biol., 2017, 12 (2), pp 336–341
DOI: 10.1021/acschembio.6b00794

Development of an Azoreductase-based Reporter System with Synthetic Fluorogenic Substrates
ACS Chem. Biol., 2017, 12 (2), pp 558–563
DOI: 10.1021/acschembio.6b00852

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ACS Chemical Neuroscience

Hitchhiker’s Guide to Voltammetry: Acute and Chronic Electrodes for in Vivo Fast-Scan Cyclic Voltammetry
Open access through ACS Editors’ Choice
ACS Chem. Neurosci., 2017, 8 (2), pp 221–234
DOI: 10.1021/acschemneuro.6b00393

Differentiating Siblings: The Case of Dopamine and Norepinephrine
ACS Chem. Neurosci., 2017, 8 (2), pp 218–220
DOI: 10.1021/acschemneuro.7b00056

Monitoring Molecules in Neuroscience Then and Now
ACS Chem. Neurosci., 2017, 8 (2), pp 215–217
DOI: 10.1021/acschemneuro.7b00043

Probing Deep Brain Circuitry: New Advances in in Vivo Calcium Measurement Strategies
ACS Chem. Neurosci., 2017, 8 (2), pp 243–251
DOI: 10.1021/acschemneuro.6b00307

Why Monitor Molecules in Neuroscience?
This article is part of the Monitoring Molecules in Neuroscience 2016 special issue.
ACS Chem. Neurosci., 2017, 8 (2), pp 211–212
DOI: 10.1021/acschemneuro.7b00052

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ACS Infectious Diseases

Introducing a New Associate Editor for ACS Infectious Diseases
ACS Infect. Dis., 2017, 3 (2), pp 110–110
DOI: 10.1021/acsinfecdis.7b00018

Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome
ACS Infect. Dis., 2017, 3 (2), pp 176–181
DOI: 10.1021/acsinfecdis.6b00172

Toward Photopharmacological Antimicrobial Chemotherapy Using Photoswitchable Amidohydrolase Inhibitors
ACS Infect. Dis., 2017, 3 (2), pp 152–161
DOI: 10.1021/acsinfecdis.6b00148

A Redox-Active Fluorescent pH Indicator for Detecting Plasmodium falciparum Strains with Reduced Responsiveness to Quinoline Antimalarial Drugs
ACS Infect. Dis., 2017, 3 (2), pp 119–131
DOI: 10.1021/acsinfecdis.5b00141

A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions
ACS Infect. Dis., 2017, 3 (2), pp 112–118
DOI: 10.1021/acsinfecdis.6b00079

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ACS Medicinal Chemistry Letters

Communicating Our Science to Our Customers: Drug Discovery in Five Simple Experiments.
ACS Med. Chem. Lett., 2017, 8 (2), pp 143–144
DOI: 10.1021/acsmedchemlett.7b00015

Intramolecular Hydrogen Bond Expectations in Medicinal Chemistry
ACS Med. Chem. Lett., 2017, 8 (2), pp 139–142
DOI: 10.1021/acsmedchemlett.7b00002

Design and Synthesis of Novel, Selective GPR40 AgoPAMs
ACS Med. Chem. Lett., 2017, 8 (2), pp 221–226
DOI: 10.1021/acsmedchemlett.6b00443

Discovery of Novel, Orally Bioavailable β-Amino Acid Azaindole Inhibitors of Influenza PB2
ACS Med. Chem. Lett., 2017, 8 (2), pp 256–260
DOI: 10.1021/acsmedchemlett.6b00486

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors
ACS Med. Chem. Lett., 2017, 8 (2), pp 239–244
DOI: 10.1021/acsmedchemlett.6b00464

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ACS Synthetic Biology

Introducing Our Authors
ACS Synth. Biol., 2017, 6 (2), pp 174–181
DOI: 10.1021/acssynbio.7b00038

Engineering of Taxadiene Synthase for Improved Selectivity and Yield of a Key Taxol Biosynthetic Intermediate
ACS Synth. Biol., 2017, 6 (2), pp 201–205
DOI: 10.1021/acssynbio.6b00206

Controlling Citrate Synthase Expression by CRISPR/Cas9 Genome Editing for n-Butanol Production in Escherichia coli
ACS Synth. Biol., 2017, 6 (2), pp 182–189
DOI: 10.1021/acssynbio.6b00134

Discovery of a Phosphonoacetic Acid Derived Natural Product by Pathway Refactoring
ACS Synth. Biol., 2017, 6 (2), pp 217–223
DOI: 10.1021/acssynbio.6b00299

A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases
ACS Synth. Biol., 2017, 6 (2), pp 326–333
DOI: 10.1021/acssynbio.6b00188

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Biochemistry

Retraction of “β-Amyloid and α-Synuclein Cooperate To Block SNARE-Dependent Vesicle Fusion”
Biochemistry, 2017, 56 (7), pp 1026–1026
DOI: 10.1021/acs.biochem.7b00054

Interaction of Zika Virus Envelope Protein with Glycosaminoglycans
Biochemistry, 2017, 56 (8), pp 1151–1162
DOI: 10.1021/acs.biochem.6b01056

Cyclotide Structure and Function: The Role of Membrane Binding and Permeation
Biochemistry, 2017, 56 (5), pp 669–682
DOI: 10.1021/acs.biochem.6b01212

Structural Analysis of the Glycosylated Intact HIV-1 gp120–b12 Antibody Complex Using Hydroxyl Radical Protein Footprinting
Open access through ACS AuthorChoice
Biochemistry, 2017, 56 (7), pp 957–970
DOI: 10.1021/acs.biochem.6b00888

Site-Specific Fluorescence Polarization for Studying the Disaggregation of α-Synuclein Fibrils by Small Molecules
Biochemistry, 2017, 56 (5), pp 683–691
DOI: 10.1021/acs.biochem.6b01060

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Bioconjugate Chemistry

Quantitative Conjugated Payload Measurement Using Enzymatic Release of Antibody–Drug Conjugate with Cleavable Linker
Bioconjugate Chem., 2017, 28 (2), pp 620–626
DOI: 10.1021/acs.bioconjchem.6b00695

Peptide-Based Stealth Nanoparticles for Targeted and pH-Triggered Delivery
Bioconjugate Chem., 2017, 28 (2), pp 627–635
DOI: 10.1021/acs.bioconjchem.6b00701

Investigation of Hydrophilic Auristatin Derivatives for Use in Antibody Drug Conjugates
Bioconjugate Chem., 2017, 28 (2), pp 371–381
DOI: 10.1021/acs.bioconjchem.6b00530

Enhanced G-Quadruplex DNA Stabilization and Telomerase Inhibition by Novel Fluorescein Derived Salen and Salphen Based Ni(II) and Pd(II) Complexes
Bioconjugate Chem., 2017, 28 (2), pp 341–352
DOI: 10.1021/acs.bioconjchem.6b00433

Automated, Resin-Based Method to Enhance the Specific Activity of Fluorine-18 Clicked PET Radiotracers
Bioconjugate Chem., 2017, 28 (2), pp 583–589
DOI: 10.1021/acs.bioconjchem.6b00678

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Biomacromolecules

Hydrogels for Therapeutic Delivery: Current Developments and Future Directions
Biomacromolecules, 2017, 18 (2), pp 316–330
DOI: 10.1021/acs.biomac.6b01604

Luminescent Difluoroboron β-Diketonate PLA–PEG Nanoparticle
Biomacromolecules, 2017, 18 (2), pp 551–561
DOI: 10.1021/acs.biomac.6b01708

Implantable Tin Porphyrin-PEG Hydrogels with pH-Responsive Fluorescence
Biomacromolecules, 2017, 18 (2), pp 562–567
DOI: 10.1021/acs.biomac.6b01715

Phase Behavior and Self-Assembly of Perfectly Sequence-Defined and Monodisperse Multiblock Copolypeptides
Biomacromolecules, 2017, 18 (2), pp 599–609
DOI: 10.1021/acs.biomac.6b01759

“Clickable” Nanogels via Thermally Driven Self-Assembly of Polymers: Facile Access to Targeted Imaging Platforms using Thiol–Maleimide Conjugation
Biomacromolecules, 2017, 18 (2), pp 490–497
DOI: 10.1021/acs.biomac.6b01576

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Journal of Agricultural and Food Chemistry

Development of a QuEChERS-Based Method for the Simultaneous Determination of Acidic Pesticides, Their Esters, and Conjugates Following Alkaline Hydrolysis
J. Agric. Food Chem., 2017, 65 (6), pp 1296–1305
DOI: 10.1021/acs.jafc.6b05407

Neuroprotective Effects of Bioavailable Polyphenol-Derived Metabolites against Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells
Open access through ACS Editors’ Choice
J. Agric. Food Chem., 2017, 65 (4), pp 752–758
DOI: 10.1021/acs.jafc.6b04538

Analytical Methods Used in the Quality Control of Honey
J. Agric. Food Chem., 2017, 65 (4), pp 690–703
DOI: 10.1021/acs.jafc.6b04776

A Perspective on Crocus sativus L. (Saffron) Constituent Crocin: A Potent Water-Soluble Antioxidant and Potential Therapy for Alzheimer’s Disease
J. Agric. Food Chem., 2017, 65 (5), pp 1005–1020
DOI: 10.1021/acs.jafc.6b04398

Chemical and Antioxidant Properties of Betalains
J. Agric. Food Chem., 2017, 65 (4), pp 675–689
DOI: 10.1021/acs.jafc.6b04208

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Journal of Chemical Theory and Computation

Multireference Perturbation Theory with Cholesky Decomposition for the Density Matrix Renormalization Group
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2017, 13 (2), pp 451–459
DOI: 10.1021/acs.jctc.6b00778

Quantitative Assessment of Molecular Dynamics Sampling for Flexible Systems
J. Chem. Theory Comput., 2017, 13 (2), pp 400–414
DOI: 10.1021/acs.jctc.6b00823

Systematic Quantum Mechanical Region Determination in QM/MM Simulation
J. Chem. Theory Comput., 2017, 13 (2), pp 563–576
DOI: 10.1021/acs.jctc.6b01049

Modeling Diversity in Structures of Bacterial Outer Membrane Lipids
J. Chem. Theory Comput., 2017, 13 (2), pp 811–824
DOI: 10.1021/acs.jctc.6b00856

A Monte Carlo Resampling Approach for the Calculation of Hybrid Classical and Quantum Free Energies
Open access through ACS AuthorChoice
J. Chem. Theory Comput., 2017, 13 (2), pp 415–424
DOI: 10.1021/acs.jctc.6b00506

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Journal of Medicinal Chemistry

Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases
J. Med. Chem., 2017, 60 (4), pp 1247–1261
DOI: 10.1021/acs.jmedchem.6b01751

Recent Advances in Scaffold Hopping
J. Med. Chem., 2017, 60 (4), pp 1238–1246
DOI: 10.1021/acs.jmedchem.6b01437

Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions
J. Med. Chem., 2017, 60 (3), pp 839–885
DOI: 10.1021/acs.jmedchem.6b00788

Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A
J. Med. Chem., 2017, 60 (3), pp 1000–1017
DOI: 10.1021/acs.jmedchem.6b01329

Structure-Based Design of Macrocyclic Factor XIa Inhibitors: Discovery of the Macrocyclic Amide Linker
J. Med. Chem., 2017, 60 (3), pp 1060–1075
DOI: 10.1021/acs.jmedchem.6b01460

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Journal of Natural Products

Diterpenoids and Lignans from Cephalotaxus fortunei
J. Nat. Prod., 2017, 80 (2), pp 356–362
DOI: 10.1021/acs.jnatprod.6b00802

Concise Syntheses of Hyrtioreticulins C and D via a C-4 Pictet–Spengler Reaction: Revised Signs of Specific Rotations
J. Nat. Prod., 2017, 80 (2), pp 241–245
DOI: 10.1021/acs.jnatprod.7b00008

Branimycins B and C, Antibiotics Produced by the Abyssal Actinobacterium Pseudonocardia carboxydivorans M-227
J. Nat. Prod., 2017, 80 (2), pp 569–573
DOI: 10.1021/acs.jnatprod.6b01107

Cultures of the Marine Bacterium Pseudovibrio denitrificans Ab134 Produce Bromotyrosine-Derived Alkaloids Previously Only Isolated from Marine Sponges
J. Nat. Prod., 2017, 80 (2), pp 235–240
DOI: 10.1021/acs.jnatprod.6b00838

Sesquiterpenoids with Various Carbocyclic Skeletons from the Flowers of Chrysanthemum indicum
J. Nat. Prod., 2017, 80 (2), pp 298–307
DOI: 10.1021/acs.jnatprod.6b00694

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The Journal of Physical Chemistry B

Editorial – Virtual Issue of JPCB on Biophysics
J. Phys. Chem. B, 2017, 121 (5), pp 913–914
DOI: 10.1021/acs.jpcb.6b12749

Characterization of Nanocellulose Using Small-Angle Neutron, X-ray, and Dynamic Light Scattering Techniques
J. Phys. Chem. B, 2017, 121 (6), pp 1340–1351
DOI: 10.1021/acs.jpcb.6b11425

A Spectroscopic and Molecular Simulation Approach toward the Binding Affinity between Lysozyme and Phenazinium Dyes: An Effect on Protein Conformation
J. Phys. Chem. B, 2017, 121 (7), pp 1475–1484
DOI: 10.1021/acs.jpcb.6b10991

The Levinthal Problem in Amyloid Aggregation: Sampling of a Flat Reaction Space
J. Phys. Chem. B, 2017, 121 (7), pp 1576–1586
DOI: 10.1021/acs.jpcb.7b00253

Coarse-Grained Molecular Simulation of the Hierarchical Self-Assembly of π-Conjugated Optoelectronic Peptides
J. Phys. Chem. B, 2017, 121 (7), pp 1684–1706
DOI: 10.1021/acs.jpcb.6b10165

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Charge Carrier Trapping at Surface Defects of Perovskite Solar Cell Absorbers: A First-Principles Study
Open access through ACS Editors’ Choice
J. Phys. Chem. Lett., 2017, 8 (4), pp 742–746
DOI: 10.1021/acs.jpclett.7b00055

Cs2InAgCl6: A New Lead-Free Halide Double Perovskite with Direct Band Gap
J. Phys. Chem. Lett., 2017, 8 (4), pp 772–778
DOI: 10.1021/acs.jpclett.6b02682

Spectroscopic Evidences for Strong Hydrogen Bonds with Selenomethionine in Proteins
J. Phys. Chem. Lett., 2017, 8 (4), pp 794–800
DOI: 10.1021/acs.jpclett.6b02931

Electron Transfer from Triplet State of TIPS-Pentacene Generated by Singlet Fission Processes to CH3NH3PbI3 Perovskite
J. Phys. Chem. Lett., 2017, 8 (4), pp 884–888
DOI: 10.1021/acs.jpclett.7b00072

First-Principles Study of Novel Two-Dimensional (C4H9NH3)2PbX4 Perovskites for Solar Cell Absorbers
J. Phys. Chem. Lett., 2017, 8 (4), pp 876–883
DOI: 10.1021/acs.jpclett.7b00003

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Journal of Proteome Research

Expansion for the Brachylophosaurus canadensis Collagen I Sequence and Additional Evidence of the Preservation of Cretaceous Protein
J. Proteome Res., 2017, 16 (2), pp 920–932
DOI: 10.1021/acs.jproteome.6b00873

The Cover Letter
J. Proteome Res., 2017, 16 (2), pp 367–367
DOI: 10.1021/acs.jproteome.6b01068

Analysis of Reproducibility of Proteome Coverage and Quantitation Using Isobaric Mass Tags (iTRAQ and TMT)
J. Proteome Res., 2017, 16 (2), pp 384–392
DOI: 10.1021/acs.jproteome.5b01154

Advancing Top-down Analysis of the Human Proteome Using a Benchtop Quadrupole-Orbitrap Mass Spectrometer
J. Proteome Res., 2017, 16 (2), pp 609–618
DOI: 10.1021/acs.jproteome.6b00698

Optimization of Acquisition and Data-Processing Parameters for Improved Proteomic Quantification by Sequential Window Acquisition of All Theoretical Fragment Ion Mass Spectrometry
J. Proteome Res., 2017, 16 (2), pp 738–747
DOI: 10.1021/acs.jproteome.6b00767

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Molecular Pharmaceutics

Polymer–Drug Nanoparticles Combine Doxorubicin Carrier and Heparin Bioactivity Functionalities for Primary and Metastatic Cancer Treatment
Mol. Pharmaceutics, 2017, 14 (2), pp 513–522
DOI: 10.1021/acs.molpharmaceut.6b00979

Measurement of in vivo Gastrointestinal Release and Dissolution of Three Locally Acting Mesalamine Formulations in Regions of the Human Gastrointestinal Tract
Mol. Pharmaceutics, 2017, 14 (2), pp 345–358
DOI: 10.1021/acs.molpharmaceut.6b00641

Effect of Particle Size on Drug Loading and Release Kinetics of Gefitinib-Loaded PLGA Microspheres
Mol. Pharmaceutics, 2017, 14 (2), pp 459–467
DOI: 10.1021/acs.molpharmaceut.6b00896

Preclinical Comparison of Albumin-Binding Radiofolates: Impact of Linker Entities on the in Vitro and in Vivo Properties
Mol. Pharmaceutics, 2017, 14 (2), pp 523–532
DOI: 10.1021/acs.molpharmaceut.6b01010

Self-Assembly PEGylation Retaining Activity (SPRA) Technology via a Host–Guest Interaction Surpassing Conventional PEGylation Methods of Proteins
Mol. Pharmaceutics, 2017, 14 (2), pp 368–376
DOI: 10.1021/acs.molpharmaceut.6b00678