Discover the Most-Read Organic/Inorganic Chemistry Articles of May 2017

What were chemists reading in May of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each organic/inorganic ACS Publications journal in May 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great May 2017 Chemistry Research:

Analytical Chemistry | Applied Chemistry | Biological Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Physical Chemistry


ACS Catalysis

Announcing the Inaugural ACS Catalysis Early Career Advisory Board
ACS Catal., 2017, 7 (5), pp 3712–3712
DOI: 10.1021/acscatal.7b01261

Supramolecular Photocatalysts for the Reduction of CO2
ACS Catal., 2017, 7 (5), pp 3394–3409
DOI: 10.1021/acscatal.7b00440

Ligand-Promoted Direct C–H Arylation of Simple Arenes: Evidence for a Cooperative Bimetallic Mechanism
Open access through ACS AuthorChoice
ACS Catal., 2017, 7 (5), pp 3336–3343
DOI: 10.1021/acscatal.7b00397

Enhancing Electrocatalytic Activity for Hydrogen Evolution by Strongly Coupled Molybdenum Nitride@Nitrogen-Doped Carbon Porous Nano-Octahedrons
ACS Catal., 2017, 7 (5), pp 3540–3547
DOI: 10.1021/acscatal.7b00120

Isolated Single-Atomic Ru Catalyst Bound on a Layered Double Hydroxide for Hydrogenation of CO2 to Formic Acid
ACS Catal., 2017, 7 (5), pp 3147–3151
DOI: 10.1021/acscatal.7b00312


ACS Combinatorial Science

One-Pot Synthesis of Densely Substituted Pyrazolo[3,4-b]-4,7-dihydropyridines
ACS Comb. Sci., 2017, 19 (5), pp 279–285
DOI: 10.1021/acscombsci.6b00156

Technical Advances in Medicinal Chemistry
ACS Comb. Sci., 2017, 19 (5), pp 277–278
DOI: 10.1021/acscombsci.7b00053

Combinatorial Library Screening with Liposomes for Discovery of Membrane Active Peptides
ACS Comb. Sci., 2017, 19 (5), pp 299–307
DOI: 10.1021/acscombsci.6b00182

Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction
Open access through ACS AuthorChoice
ACS Comb. Sci., 2017, 19 (5), pp 343–350
DOI: 10.1021/acscombsci.7b00033

A One-Pot Multicomponent 1,3-Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Dihydrothiophenone-Engrafted Dispiro Hybrid Heterocycles
ACS Comb. Sci., 2017, 19 (5), pp 308–314
DOI: 10.1021/acscombsci.6b00186


ACS Medicinal Chemistry Letters

INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology
Open access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2017, 8 (5), pp 486–491
DOI: 10.1021/acsmedchemlett.6b00391

Biocatalysis in the Pharmaceutical Industry: The Need for Speed
ACS Med. Chem. Lett., 2017, 8 (5), pp 476–480
DOI: 10.1021/acsmedchemlett.7b00114

Toward Resolving the Resveratrol Conundrum: Synthesis and in Vivo Pharmacokinetic Evaluation of BCP–Resveratrol
ACS Med. Chem. Lett., 2017, 8 (5), pp 516–520
DOI: 10.1021/acsmedchemlett.7b00018

Discovery of Fevipiprant (NVP-QAW039), a Potent and Selective DP2 Receptor Antagonist for Treatment of Asthma
ACS Med. Chem. Lett., 2017, 8 (5), pp 582–586
DOI: 10.1021/acsmedchemlett.7b00157

Development of Highly Affine and Selective Fluorinated Cannabinoid Type 2 Receptor Ligands
ACS Med. Chem. Lett., 2017, 8 (5), pp 566–571
DOI: 10.1021/acsmedchemlett.7b00129


Bioconjugate Chemistry

General Dialdehyde Click Chemistry for Amine Bioconjugation
Bioconjugate Chem., 2017, 28 (5), pp 1422–1433
DOI: 10.1021/acs.bioconjchem.7b00106

Synthesis of BODIPY-Peptide Conjugates for Fluorescence Labeling of EGFR Overexpressing Cells
Bioconjugate Chem., 2017, 28 (5), pp 1566–1579
DOI: 10.1021/acs.bioconjchem.7b00211

Dual Plug-and-Display Synthetic Assembly Using Orthogonal Reactive Proteins for Twin Antigen Immunization
Open access through ACS AuthorChoice
Bioconjugate Chem., 2017, 28 (5), pp 1544–1551
DOI: 10.1021/acs.bioconjchem.7b00174

Acyl Fluorides: Fast, Efficient, and Versatile Lysine-Based Protein Conjugation via Plug-and-Play Strategy
Bioconjugate Chem., 2017, 28 (5), pp 1452–1457
DOI: 10.1021/acs.bioconjchem.7b00141

Bioimaging with Macromolecular Probes Incorporating Multiple BODIPY Fluorophore
Bioconjugate Chem., 2017, 28 (5), pp 1519–1528
DOI: 10.1021/acs.bioconjchem.7b00166


Inorganic Chemistry

Design of a Family of Ln3 Triangles with the HAT Ligand (1,4,5,8,9,12-Hexaazatriphenylene): Single-Molecule Magnetism
Inorg. Chem., 2017, 56 (10), pp 5594–5610
DOI: 10.1021/acs.inorgchem.6b03031

A General Model of Sensitized Luminescence in Lanthanide-Based Coordination Polymers and Metal–Organic Framework Materials
Inorg. Chem., 2017, 56 (10), pp 5544–5552
DOI: 10.1021/acs.inorgchem.6b02838

Tuning the Fe(II/III) Redox Potential in Nonheme Fe(II)–Hydroxo Complexes through Primary and Secondary Coordination Sphere Modifications
Inorg. Chem., 2017, 56 (9), pp 4852–4863
DOI: 10.1021/acs.inorgchem.6b03071

Polymorphous Al-MOFs Based on V-Shaped Linker Molecules: Synthesis, Properties, and in Situ Investigation of Their Crystallization
Inorg. Chem., 2017, 56 (10), pp 5851–5862
DOI: 10.1021/acs.inorgchem.7b00202

Palladium(II) Weak-Link Approach Complexes Bearing Hemilabile N-Heterocyclic Carbene–Thioether Ligands
Inorg. Chem., 2017, 56 (10), pp 5902–5910
DOI: 10.1021/acs.inorgchem.7b00543


Journal of Medicinal Chemistry

Discovery of 2-[[2-Ethyl-6-[4-[2-(3-hydroxyazetidin-1-yl)-2-oxoethyl]piperazin-1-yl]-8-methylimidazo[1,2-a]pyridin-3-yl]methylamino]-4-(4-fluorophenyl)thiazole-5-carbonitrile (GLPG1690), a First-in-Class Autotaxin Inhibitor Undergoing Clinical Evaluation for the Treatment of Idiopathic Pulmonary Fibrosis
Open access through ACS Editors’ Choice
J. Med. Chem., 2017, 60 (9), pp 3580–3590
DOI: 10.1021/acs.jmedchem.7b00032

Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors
J. Med. Chem., 2017, 60 (10), pp 4386–4402
DOI: 10.1021/acs.jmedchem.7b00359

Pentafluorosulfanyl-Substituted Benzopyran Analogues As New Cyclooxygenase-2 Inhibitors with Excellent Pharmacokinetics and Efficacy in Blocking Inflammation
J. Med. Chem., 2017, 60 (10), pp 4135–4146
DOI: 10.1021/acs.jmedchem.6b01484

Discovery of a B-Cell Lymphoma 6 Protein–Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach
J. Med. Chem., 2017, 60 (10), pp 4358–4368
DOI: 10.1021/acs.jmedchem.7b00313

7-Substituted 2-Nitro-5,6-dihydroimidazo[2,1-b][1,3]oxazines: Novel Antitubercular Agents Lead to a New Preclinical Candidate for Visceral Leishmaniasis
J. Med. Chem., 2017, 60 (10), pp 4212–4233
DOI: 10.1021/acs.jmedchem.7b00034


Journal of Natural Products

Total Synthesis of Tedarene A
J. Nat. Prod., 2017, 80 (5), pp 1623–1630
DOI: 10.1021/acs.jnatprod.7b00199

Structural Revision and Biosynthesis of the Fungal Phytotoxins Phyllostictines A and B
J. Nat. Prod., 2017, 80 (5), pp 1235–1240
DOI: 10.1021/acs.jnatprod.7b00183

Vitepyrroloids A–D, 2-Cyanopyrrole-Containing Labdane Diterpenoid Alkaloids from the Leaves of Vitex trifolia
J. Nat. Prod., 2017, 80 (5), pp 1679–1683
DOI: 10.1021/acs.jnatprod.6b01195

Antiplasmodial Sesquiterpenoid Lactones from Trichospira verticillata: Structure Elucidation by Spectroscopic Methods and Comparison of Experimental and Calculated ECD Data
J. Nat. Prod., 2017, 80 (5), pp 1639–1647
DOI: 10.1021/acs.jnatprod.7b00247

Antimicrobial Spirotetronate Metabolites from Marine-Derived Micromonospora harpali SCSIO GJ089
J. Nat. Prod., 2017, 80 (5), pp 1594–1603
DOI: 10.1021/acs.jnatprod.7b00176


The Journal of Organic Chemistry

Multiple Approaches to the In Situ Generation of Anhydrous Tetraalkylammonium Fluoride Salts for SNAr Fluorination Reactions
J. Org. Chem., 2017, 82 (10), pp 5020–5026
DOI: 10.1021/acs.joc.7b00481

Ruthenium(II)-Catalyzed Redox-Neutral [3+2] Annulation of Indoles with Internal Alkynes via C–H Bond Activation: Accessing a Pyrroloindolone Scaffold
J. Org. Chem., 2017, 82 (10), pp 5263–5273
DOI: 10.1021/acs.joc.7b00575

Asymmetric Synthesis of cis-3,4-Dihydrocoumarins via [4 + 2] Cycloadditions Catalyzed by Amidine Derivatives
J. Org. Chem., 2017, 82 (10), pp 5424–5432
DOI: 10.1021/acs.joc.7b00367

Photoredox-Catalyzed Hydrodifluoroalkylation of Alkenes Using Difluorohaloalkyl Compounds and a Hantzsch Ester
J. Org. Chem., 2017, 82 (10), pp 5469–5474
DOI: 10.1021/acs.joc.7b00609

General C–H Arylation Strategy for the Synthesis of Tunable Visible Light-Emitting Benzo[a]imidazo[2,1,5-c,d]indolizine Fluorophores
J. Org. Chem., 2017, 82 (10), pp 5046–5067
DOI: 10.1021/acs.joc.6b02928


Molecular Pharmaceutics

Encapsulation of Ibuprofen in CD-MOF and Related Bioavailability Studies
Mol. Pharmaceutics, 2017, 14 (5), pp 1831–1839
DOI: 10.1021/acs.molpharmaceut.7b00168

Bioconjugate Therapeutics: Current Progress and Future Perspective
Mol. Pharmaceutics, 2017, 14 (5), pp 1321–1324
DOI: 10.1021/acs.molpharmaceut.7b00263

Lipid–Drug Conjugate for Enhancing Drug Delivery
Mol. Pharmaceutics, 2017, 14 (5), pp 1325–1338
DOI: 10.1021/acs.molpharmaceut.6b01027

Tracking Antibody Distribution with Near-Infrared Fluorescent Dyes: Impact of Dye Structure and Degree of Labeling on Plasma Clearance
Open access through ACS Editors’ Choice
Mol. Pharmaceutics, 2017, 14 (5), pp 1623–1633
DOI: 10.1021/acs.molpharmaceut.6b01091

Iron Oxide Nanoparticle Based Contrast Agents for Magnetic Resonance Imaging
Mol. Pharmaceutics, 2017, 14 (5), pp 1352–1364
DOI: 10.1021/acs.molpharmaceut.6b00839


Organic Letters 

B(C6F5)3-Catalyzed Michael Reactions: Aromatic C–H as Nucleophiles
Open access through ACS Editors’ Choice
Org. Lett., 2017, 19 (10), pp 2568–2571
DOI: 10.1021/acs.orglett.7b00720

Decarboxylative Borylation of Aliphatic Esters under Visible-Light Photoredox Conditions
Org. Lett., 2017, 19 (10), pp 2770–2773
DOI: 10.1021/acs.orglett.7b01181

Ni-Catalyzed Reductive Cross-Coupling of Amides with Aryl Iodide Electrophiles via C–N Bond Activation
Org. Lett., 2017, 19 (10), pp 2536–2539
DOI: 10.1021/acs.orglett.7b00831

One-Pot, Metal-Free Conversion of Anilines to Aryl Bromides and Iodides
Org. Lett., 2017, 19 (10), pp 2518–2521
DOI: 10.1021/acs.orglett.7b00771

Diastereoselective Base-Catalyzed Formal [4 + 2] Cycloadditions of N-Sulfonyl Imines and Cyclic Anhydrides
Org. Lett., 2017, 19 (10), pp 2466–2469
DOI: 10.1021/acs.orglett.7b00468


Organic Process Research & Development

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2017, 21 (5), pp 675–688
DOI: 10.1021/acs.oprd.7b00163

Development of a Process Route to the FAK/ALK Dual Inhibitor TEV-37440
Org. Process Res. Dev., 2017, 21 (5), pp 740–747
DOI: 10.1021/acs.oprd.7b00070

Continuous Selective Hydrogenation of Refametinib Iodo-nitroaniline Key Intermediate DIM-NA over Raney Cobalt Catalyst at kg/day Scale with Online UV–Visible Conversion Control
Org. Process Res. Dev., 2017, 21 (5), pp 705–714
DOI: 10.1021/acs.oprd.7b00039

Impurity Occurrence and Removal in Crystalline Products from Process Reactions
Org. Process Res. Dev., 2017, 21 (5), pp 689–704
DOI: 10.1021/acs.oprd.6b00403

Highly Modular Flow Cell for Electroorganic Synthesis
Org. Process Res. Dev., 2017, 21 (5), pp 771–778
DOI: 10.1021/acs.oprd.7b00123



Iron-Catalyzed Amide Formation from the Dehydrogenative Coupling of Alcohols and Secondary Amines
Organometallics, 2017, 36 (10), pp 2020–2025
DOI: 10.1021/acs.organomet.7b00258

Synthesis and Electrochemical Properties of Half-Sandwich Rhodium and Iridium Methyl Complexes
Organometallics, 2017, 36 (10), pp 1897–1905
DOI: 10.1021/acs.organomet.7b00136

Olefin Polymerization by Dinuclear Zirconium Catalysts Based on Rigid Teraryl Frameworks: Effects on Tacticity and Copolymerization Behavior
Organometallics, 2017, 36 (10), pp 1915–1928
DOI: 10.1021/acs.organomet.7b00015

Photochemical Production of Ethane from an Iridium Methyl Complex
Organometallics, 2017, 36 (10), pp 1906–1914
DOI: 10.1021/acs.organomet.7b00175

A New Mode of Operation of Pd-NHC Systems Studied in a Catalytic Mizoroki–Heck Reaction
Open access through ACS Editors’ Choice
Organometallics, 2017, 36 (10), pp 1981–1992
DOI: 10.1021/acs.organomet.7b00184










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