Discover the Most-Read Organic/Inorganic Chemistry Articles of October 2017

What were chemists reading in October of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each organic and inorganic chemistry ACS Publications journal in October 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great October 2017 Chemistry Research:

Analytical Chemistry | Applied Chemistry | Biological Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Physical Chemistry

ACS Catalysis

Nickel-Based Electrocatalysts for Energy-Related Applications: Oxygen Reduction, Oxygen Evolution, and Hydrogen Evolution Reactions
ACS Catal., 2017, 7 (10), pp 7196–7225
DOI: 10.1021/acscatal.7b01800

Accounting for Bifurcating Pathways in the Screening for CO2 Reduction Catalysts
ACS Catal., 2017, 7 (10), pp 7346–7351
DOI: 10.1021/acscatal.7b02917

Increasing Oxide Reducibility: The Role of Metal/Oxide Interfaces in the Formation of Oxygen Vacancies
Open Access Through ACS AuthorChoice.
ACS Catal., 2017, 7 (10), pp 6493–6513
DOI: 10.1021/acscatal.7b01913

Visible-Light Photocatalytic Decarboxylation of α,β-Unsaturated Carboxylic Acids: Facile Access to Stereoselective Difluoromethylated Styrenes in Batch and Flow
Open Access Through ACS AuthorChoice.
ACS Catal., 2017, 7 (10), pp 7136–7140
DOI: 10.1021/acscatal.7b03019

Vertically Aligned MoS2/Mo2C hybrid Nanosheets Grown on Carbon Paper for Efficient Electrocatalytic Hydrogen Evolution
ACS Catal., 2017, 7 (10), pp 7312–7318
DOI: 10.1021/acscatal.7b02885


ACS Combinatorial Science

1,3-Dipolar Cycloaddition Reactions for the Synthesis of Novel Oxindole Derivatives and Their Cytotoxic Properties
ACS Comb. Sci., 2017, 19 (10), pp 633–639
DOI: 10.1021/acscombsci.7b00044

Machine Learning Using Combined Structural and Chemical Descriptors for Prediction of Methane Adsorption Performance of Metal Organic Frameworks (MOFs)
ACS Comb. Sci., 2017, 19 (10), pp 640–645
DOI: 10.1021/acscombsci.7b00056

Oligonucleotide Hybridization Combined with Competitive Antibody Binding for the Truncation of a High-Affinity Aptamer
ACS Comb. Sci., 2017, 19 (10), pp 609–617
DOI: 10.1021/acscombsci.6b00163

High-Throughput Structural and Functional Characterization of the Thin Film Materials System Ni–Co–Al
ACS Comb. Sci., 2017, 19 (10), pp 618–624
DOI: 10.1021/acscombsci.6b00176

A Linker for the Solid-Phase Synthesis of Hydroxamic Acids and Identification of HDAC6 Inhibitors
ACS Comb. Sci., 2017, 19 (10), pp 657–669
DOI: 10.1021/acscombsci.7b00068


ACS Medicinal Chemistry Letters

Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases
ACS Med. Chem. Lett., 2017, 8 (10), pp 1048–1053
DOI: 10.1021/acsmedchemlett.7b00258

Antibody–Drug Conjugates for the Treatment of Inflammation
ACS Med. Chem. Lett., 2017, 8 (10), pp 992–994
DOI: 10.1021/acsmedchemlett.7b00377

Anti-inflammatory Silent Agonists
ACS Med. Chem. Lett., 2017, 8 (10), pp 989–991
DOI: 10.1021/acsmedchemlett.7b00368

Artificial Macrocycles as Potent p53–MDM2 Inhibitors
ACS Med. Chem. Lett., 2017, 8 (10), pp 1025–1030
DOI: 10.1021/acsmedchemlett.7b00219

Indolinone Inhibitors of ENT1 for the Treatment of Schizophrenia
ACS Med. Chem. Lett., 2017, 8 (10), pp 995–996
DOI: 10.1021/acsmedchemlett.7b00378


Bioconjugate Chemistry

Automated Solid-Phase Click Synthesis of Oligonucleotide Conjugates: From Small Molecules to Diverse N-Acetylgalactosamine Clusters
Bioconjugate Chem., 2017, 28 (10), pp 2599–2607
DOI: 10.1021/acs.bioconjchem.7b00462

Transglutaminase-Catalyzed Bioconjugation Using One-Pot Metal-Free Bioorthogonal Chemistry
Bioconjugate Chem., 2017, 28 (10), pp 2518–2523
DOI: 10.1021/acs.bioconjchem.7b00509

Attachment Site Cysteine Thiol pKa Is a Key Driver for Site-Dependent Stability of THIOMAB Antibody–Drug Conjugates
Bioconjugate Chem., 2017, 28 (10), pp 2538–2548
DOI: 10.1021/acs.bioconjchem.7b00365

Polyethylene Glycol Based Changes to β-Sheet Protein Conformational and Proteolytic Stability Depend on Conjugation Strategy and Location
Bioconjugate Chem., 2017, 28 (10), pp 2507–2513
DOI: 10.1021/acs.bioconjchem.7b00281

Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots In Vivo
Bioconjugate Chem., 2017, 28 (10), pp 2608–2619
DOI: 10.1021/acs.bioconjchem.7b00466


Inorganic Chemistry

Redox-Active Bis(phenolate) N-Heterocyclic Carbene [OCO] Pincer Ligands Support Cobalt Electron Transfer Series Spanning Four Oxidation States
Inorg. Chem., 2017, 56 (20), pp 12421–12435
DOI: 10.1021/acs.inorgchem.7b01906

Synthesis of a Zr-Based Metal–Organic Framework with Spirobifluorenetetrabenzoic Acid for the Effective Removal of Nerve Agent Simulants
Inorg. Chem., 2017, 56 (20), pp 12098–12101
DOI: 10.1021/acs.inorgchem.7b02022

Curcumin “Drug” Stabilized in Oxidovanadium(IV)-BODIPY Conjugates for Mitochondria-Targeted Photocytotoxicity
Inorg. Chem., 2017, 56 (20), pp 12457–12468
DOI: 10.1021/acs.inorgchem.7b01924

Viewpoint: Inorganic Materials for UV and Deep-UV Nonlinear-Optical Applications
Inorg. Chem., 2017, 56 (20), pp 12077–12085
DOI: 10.1021/acs.inorgchem.7b02184

Single-Crystal to Single-Crystal Transformation of a Nonporous Fe(II) Metal–Organic Framework into a Porous Metal–Organic Framework via a Solid-State Reaction
Inorg. Chem., 2017, 56 (20), pp 12337–12347
DOI: 10.1021/acs.inorgchem.7b01818


Journal of Medicinal Chemistry

Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat
J. Med. Chem., 2017, 60 (20), pp 8336–8357
DOI: 10.1021/acs.jmedchem.7b00678

Fragment-Based Discovery and Optimization of Enzyme Inhibitors by Docking of Commercial Chemical Space
J. Med. Chem., 2017, 60 (19), pp 8160–8169
DOI: 10.1021/acs.jmedchem.7b01006

Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor
J. Med. Chem., 2017, 60 (20), pp 8369–8384
DOI: 10.1021/acs.jmedchem.7b00746

Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements
Open Access Through ACS AuthorChoice.
J. Med. Chem., 2017, 60 (19), pp 8183–8191
DOI: 10.1021/acs.jmedchem.7b01071

In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery
J. Med. Chem., 2017, 60 (20), pp 8552–8564
DOI: 10.1021/acs.jmedchem.7b01075


Journal of Natural Products

3,5-Dimethylorsellinic Acid Derived Meroterpenoids from Penicillium chrysogenum MT-12, an Endophytic Fungus Isolated from Huperzia serrata
J. Nat. Prod., 2017, 80 (10), pp 2699–2707
DOI: 10.1021/acs.jnatprod.7b00438

Metabolites from the Plant Endophytic Fungus Aspergillus sp. CPCC 400735 and Their Anti-HIV Activities
J. Nat. Prod., 2017, 80 (10), pp 2595–2601
DOI: 10.1021/acs.jnatprod.6b00878

Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata
J. Nat. Prod., 2017, 80 (10), pp 2620–2629
DOI: 10.1021/acs.jnatprod.7b00113

Lorneic Acid Analogues from an Endophytic Actinomycete
J. Nat. Prod., 2017, 80 (10), pp 2615–2619
DOI: 10.1021/acs.jnatprod.7b00056

Sesquiterpenes from the Endophyte Glomerella cingulata
J. Nat. Prod., 2017, 80 (10), pp 2609–2614
DOI: 10.1021/acs.jnatprod.7b00054


The Journal of Organic Chemistry

Removal of Triphenylphosphine Oxide by Precipitation with Zinc Chloride in Polar Solvents
J. Org. Chem., 2017, 82 (19), pp 9931–9936
DOI: 10.1021/acs.joc.7b00459

Retraction of “Asymmetric Synthesis of Apratoxin E”
J. Org. Chem., 2017, 82 (20), pp 11310–11310
DOI: 10.1021/acs.joc.7b01414

Triquinanes and Related Sesquiterpenes Revisited Computationally: Structure Corrections of Hirsutanols B and D, Hirsutenol E, Cucumin B, Antrodins C–E, Chondroterpenes A and H, Chondrosterins C and E, Dichrocephone A, and Pethybrene
Open Access Through ACS Editors’ Choice.
J. Org. Chem., 2017, 82 (20), pp 10795–10802
DOI: 10.1021/acs.joc.7b02018

Natural Products and Their Mimics as Targets of Opportunity for Discovery
Open Access Through ACS Editors’ Choice.
J. Org. Chem., 2017, 82 (20), pp 10757–10794
DOI: 10.1021/acs.joc.7b01368

Total Synthesis of (±)-Cermizine B
J. Org. Chem., 2017, 82 (20), pp 11110–11116
DOI: 10.1021/acs.joc.7b02073


Molecular Pharmaceutics

Crown Ethers: Novel Permeability Enhancers for Ocular Drug Delivery?
Open Access Through ACS AuthorChoice.
Mol. Pharmaceutics, 2017, 14 (10), pp 3528–3538
DOI: 10.1021/acs.molpharmaceut.7b00556

Charge Shielding Prevents Aggregation of Supercharged GFP Variants at High Protein Concentration
Mol. Pharmaceutics, 2017, 14 (10), pp 3269–3280
DOI: 10.1021/acs.molpharmaceut.7b00322

ImmunoPET Imaging of CD146 in Murine Models of Intrapulmonary Metastasis of Non-Small Cell Lung Cancer
Mol. Pharmaceutics, 2017, 14 (10), pp 3239–3247
DOI: 10.1021/acs.molpharmaceut.7b00216

Design and Solidification of Fast-Releasing Clofazimine Nanoparticles for Treatment of Cryptosporidiosis
Open Access Through ACS AuthorChoice.
Mol. Pharmaceutics, 2017, 14 (10), pp 3480–3488
DOI: 10.1021/acs.molpharmaceut.7b00521

Using Peptide Aptamer Targeted Polymers as a Model Nanomedicine for Investigating Drug Distribution in Cancer Nanotheranostics
Mol. Pharmaceutics, 2017, 14 (10), pp 3539–3549
DOI: 10.1021/acs.molpharmaceut.7b00560


Organic Letters

Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine
Org. Lett., 2017, 19 (19), pp 5150–5153
DOI: 10.1021/acs.orglett.7b02434

Oxidative Annulations Involving DMSO and Formamide: K2S2O8 Mediated Syntheses of Quinolines and Pyrimidines
Org. Lett., 2017, 19 (20), pp 5673–5676
DOI: 10.1021/acs.orglett.7b02838

Cobalt-Catalyzed Decarboxylative C–H (Hetero)Arylation for the Synthesis of Arylheteroarenes and Unsymmetrical Biheteroaryls
Org. Lett., 2017, 19 (20), pp 5589–5592
DOI: 10.1021/acs.orglett.7b02730

Total Synthesis of (−)-Rhazinilam and Formal Synthesis of (+)-Eburenine and (+)-Aspidospermidine: Asymmetric Cu-Catalyzed Propargylic Substitution
Org. Lett., 2017, 19 (20), pp 5529–5532
DOI: 10.1021/acs.orglett.7b02619

Synthesis of Diverse o-Arylthio-Substituted Diaryl Ethers by Direct Oxythiolation of Arynes with Diaryl Sulfoxides Involving Migratory O-Arylation
Org. Lett., 2017, 19 (20), pp 5521–5524
DOI: 10.1021/acs.orglett.7b02599


Organic Process Research & Development

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2017, 21 (10), pp 1453–1463
DOI: 10.1021/acs.oprd.7b00303

Green Chemistry Articles of Interest to The Pharmaceutical Industry
Org. Process Res. Dev., 2017, 21 (10), pp 1464–1477
DOI: 10.1021/acs.oprd.7b00292

Process Development for the Synthesis of a Selective M1 and M4 Muscarinic Acetylcholine Receptors Agonist
Org. Process Res. Dev., 2017, 21 (10), pp 1610–1615
DOI: 10.1021/acs.oprd.7b00236

Potential Safety Hazards Associated with Using Acetonitrile and a Strong Aqueous Base
Org. Process Res. Dev., 2017, 21 (10), pp 1501–1508
DOI: 10.1021/acs.oprd.7b00158

Development of a General Protocol To Prepare 2H-1,3-Benzoxazine Derivatives
Open Access Through ACS Editors’ Choice.
Org. Process Res. Dev., 2017, 21 (10), pp 1547–1556
DOI: 10.1021/acs.oprd.7b00209



Visible Light Photocatalysis Using a Commercially Available Iron Compound
Organometallics, 2017, 36 (20), pp 3891–3895
DOI: 10.1021/acs.organomet.7b00499

Synthesis and Catalytic Activity of PNP-Supported Iron Complexes with Ancillary Isonitrile Ligands
Organometallics, 2017, 36 (20), pp 3995–4004
DOI: 10.1021/acs.organomet.7b00602

Phosphines as Silylium Ion Carriers for Controlled C–O Deoxygenation: Catalyst Speciation and Turnover Mechanisms
Organometallics, 2017, 36 (20), pp 4047–4053
DOI: 10.1021/acs.organomet.7b00689

Computational Study of Methane C–H Activation by Earth-Abundant Metal Amide/Aminyl Complexes
Organometallics, 2017, 36 (20), pp 3987–3994
DOI: 10.1021/acs.organomet.7b00600

Ru(II) Complexes with a Chemical and Redox-Active S2N2 Ligand: Structures, Electrochemistry, and Metal–Ligand Cooperativity
Organometallics, 2017, 36 (20), pp 4020–4031
DOI: 10.1021/acs.organomet.7b00623

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