Discover the Most-Read Organic/Inorganic Chemistry Articles of November 2017

What were chemists reading in November of 2017? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each organic and inorganic chemistry ACS Publications journal in November 2017, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great November 2017 Chemistry Research:

Analytical Chemistry | Applied Chemistry | Biological Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry  | Physical Chemistry


ACS Catalysis

Photocatalytic Water Splitting: Quantitative Approaches toward Photocatalyst by Design
Open Access Through ACS AuthorChoice
ACS Catal., 2017, 7 (11), pp 8006–8022
DOI: 10.1021/acscatal.7b02662

Carbon-Based Electrocatalysts for Hydrogen and Oxygen Evolution Reactions
ACS Catal., 2017, 7 (11), pp 7855–7865
DOI: 10.1021/acscatal.7b02718

Visible-Light-Driven Synthesis of 4-Alkyl/Aryl-2-Aminothiazoles Promoted by In Situ Generated Copper Photocatalyst
ACS Catal., 2017, 7 (11), pp 7941–7945
DOI: 10.1021/acscatal.7b02818

ZIF-67-Derived Nanoreactors for Controlling Product Selectivity in CO2 Hydrogenation
ACS Catal., 2017, 7 (11), pp 7509–7519
DOI: 10.1021/acscatal.7b01827

Two-Dimensional Mesoporous Carbon Doped with Fe–N Active Sites for Efficient Oxygen Reduction
ACS Catal., 2017, 7 (11), pp 7638–7646
DOI: 10.1021/acscatal.7b02101


ACS Combinatorial Science

Microwave-Assisted Regioselective Synthesis of 3-Functionalized Indole Derivatives via Three-Component Domino Reaction
ACS Comb. Sci., 2017, 19 (11), pp 708–713
DOI: 10.1021/acscombsci.7b00126

Parallel Synthesis of 1H-Pyrazolo[3,4-d]pyrimidines via Condensation of N-Pyrazolylamides and Nitriles
ACS Comb. Sci., 2017, 19 (11), pp 675–680
DOI: 10.1021/acscombsci.7b00116

Skeletal Diversity in Combinatorial Fashion: A New Format for the Castagnoli–Cushman Reaction
ACS Comb. Sci., 2017, 19 (11), pp 702–707
DOI: 10.1021/acscombsci.7b00118

Library Design-Facilitated High-Throughput Sequencing of Synthetic Peptide Libraries
ACS Comb. Sci., 2017, 19 (11), pp 694–701
DOI: 10.1021/acscombsci.7b00109

How Many Bulk Metallic Glasses Are There?
ACS Comb. Sci., 2017, 19 (11), pp 687–693
DOI: 10.1021/acscombsci.7b00048


ACS Medicinal Chemistry Letters

Selective Estrogen Receptor Degraders (SERDs): A Promising Treatment to Overcome Resistance to Endocrine Therapy in ERα-Positive Breast Cancer
ACS Med. Chem. Lett., 2017, 8 (11), pp 1129–1131
DOI: 10.1021/acsmedchemlett.7b00424

Selective Inhibitors of Phosphodiesterase 4B (PDE-4B) May Provide a Better Treatment for CNS, Metabolic, Autoimmune, and Inflammatory Diseases
ACS Med. Chem. Lett., 2017, 8 (11), pp 1132–1133
DOI: 10.1021/acsmedchemlett.7b00425

Lysine-Specific Demethylase 1 (LSD1) Inhibitors as Potential Treatment for Different Types of Cancers
ACS Med. Chem. Lett., 2017, 8 (11), pp 1134–1135
DOI: 10.1021/acsmedchemlett.7b00426

Discovery of Indolinone-Based Multikinase Inhibitors as Potential Therapeutics for Idiopathic Pulmonary Fibrosis
ACS Med. Chem. Lett., 2017, 8 (11), pp 1142–1147
DOI: 10.1021/acsmedchemlett.7b00164

Benzoxaboroles as Efficient Inhibitors of the β-Carbonic Anhydrases from Pathogenic Fungi: Activity and Modeling Study
ACS Med. Chem. Lett., 2017, 8 (11), pp 1194–1198
DOI: 10.1021/acsmedchemlett.7b00369


Bioconjugate Chemistry

Activated Microglia Targeting Dendrimer–Minocycline Conjugate as Therapeutics for Neuroinflammation
Bioconjugate Chem., 2017, 28 (11), pp 2874–2886
DOI: 10.1021/acs.bioconjchem.7b00569

Enzymatic Installation of Functional Molecules on Amyloid-Based Polymers
Bioconjugate Chem., 2017, 28 (11), pp 2687–2691
DOI: 10.1021/acs.bioconjchem.7b00479

Facile Formation of Gold-Nanoparticle-Loaded γ-Polyglutamic Acid Nanogels for Tumor Computed Tomography Imaging
Bioconjugate Chem., 2017, 28 (11), pp 2692–2697
DOI: 10.1021/acs.bioconjchem.7b00571

Improved Photoinduced Fluorogenic Alkene–Tetrazole Reaction for Protein Labeling
Bioconjugate Chem., 2017, 28 (11), pp 2859–2864
DOI: 10.1021/acs.bioconjchem.7b00562

Metal–Organic Frameworks@Polymer Composites Containing Cyanines for Near-Infrared Fluorescence Imaging and Photothermal Tumor Therapy
Bioconjugate Chem., 2017, 28 (11), pp 2784–2793
DOI: 10.1021/acs.bioconjchem.7b00508


Inorganic Chemistry

A New Bis(phthalocyaninato) Terbium Single-Ion Magnet with an Overall Excellent Magnetic Performance
Inorg. Chem., 2017, 56 (22), pp 13889–13896
DOI: 10.1021/acs.inorgchem.7b02010

A Water-Stable Twofold Interpenetrating Microporous MOF for Selective CO2 Adsorption and Separation
Inorg. Chem., 2017, 56 (22), pp 13991–13997
DOI: 10.1021/acs.inorgchem.7b02136

Carbon Dioxide Insertion into Group 9 and 10 Metal–Element σ Bonds
Inorg. Chem., 2017, 56 (22), pp 13655–13678
DOI: 10.1021/acs.inorgchem.7b02315

Catalytic Water Oxidation by a Bio-inspired Nickel Complex with a Redox-Active Ligand
Inorg. Chem., 2017, 56 (22), pp 13638–13641
DOI: 10.1021/acs.inorgchem.7b02166

Characterizing Defects in a UiO-AZB Metal–Organic Framework
Inorg. Chem., 2017, 56 (22), pp 13777–13784
DOI: 10.1021/acs.inorgchem.7b01801


Journal of Medicinal Chemistry

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)
J. Med. Chem., 2017, 60 (22), pp 9184–9204
DOI: 10.1021/acs.jmedchem.7b00941

Identification of 4-Phenoxyquinoline Based Inhibitors for L1196M Mutant of Anaplastic Lymphoma Kinase by Structure-Based Design
J. Med. Chem., 2017, 60 (22), pp 9205–9221
DOI: 10.1021/acs.jmedchem.7b01039

Structure-Based Design and Discovery of New M2 Receptor Agonists
J. Med. Chem., 2017, 60 (22), pp 9239–9250
DOI: 10.1021/acs.jmedchem.7b01113

Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein–Protein Interactions
Open access through ACS AuthorChoice
J. Med. Chem., 2017, 60 (21), pp 8982–8988
DOI: 10.1021/acs.jmedchem.7b01221

Structure–Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands
J. Med. Chem., 2017, 60 (22), pp 9142–9161
DOI: 10.1021/acs.jmedchem.7b00797


Journal of Natural Products

Houttuynoid M, an Anti-HSV Active Houttuynoid from Houttuynia cordata Featuring a Bis-houttuynin Chain Tethered to a Flavonoid Core
J. Nat. Prod., 2017, 80 (11), pp 3010–3013
DOI: 10.1021/acs.jnatprod.7b00620

Natural Products with Heteroatom-Rich Ring Systems
J. Nat. Prod., 2017, 80 (11), pp 3060–3079
DOI: 10.1021/acs.jnatprod.7b00575

Deinococcucins A–D, Aminoglycolipids from Deinococcus sp., a Gut Bacterium of the Carpenter Ant Camponotus japonicusa
J. Nat. Prod., 2017, 80 (11), pp 2910–2916
DOI: 10.1021/acs.jnatprod.7b00426

Cytotoxic Cardiac Glycoside Constituents of Vallaris glabra Leaves
J. Nat. Prod., 2017, 80 (11), pp 2987–2996
DOI: 10.1021/acs.jnatprod.7b00554

Bacilotetrins A and B, Anti-Staphylococcal Cyclic-Lipotetrapeptides from a Marine-
J. Nat. Prod., 2017, 80 (11), pp 2889–2892
DOI: 10.1021/acs.jnatprod.7b00356


The Journal of Organic Chemistry

Total Synthesis of Avrainvilleol
J. Org. Chem., 2017, 82 (21), pp 11655–11658
DOI: 10.1021/acs.joc.7b02028

Concentrated Aqueous Sodium Tosylate as Green Medium for Alkene Oxidation and Nucleophilic Substitution Reactions
J. Org. Chem., 2017, 82 (21), pp 11609–11612
DOI: 10.1021/acs.joc.7b01679

Stereoselective and Regioselective Synthesis of Heterocycles via Copper-Catalyzed Additions of Amine Derivatives and Alcohols to Alkenes
J. Org. Chem., 2017, 82 (21), pp 11311–11325
DOI: 10.1021/acs.joc.7b02072

Synthesis of Benzoxazoles Using Electrochemically Generated Hypervalent Iodine
Open Access Through ACS Editors’ Choice
J. Org. Chem., 2017, 82 (22), pp 11669–11681
DOI: 10.1021/acs.joc.7b01686

Editorial for the Special Issue on Hypervalent Iodine Reagents
J. Org. Chem., 2017, 82 (22), pp 11667–11668
DOI: 10.1021/acs.joc.7b02531


Molecular Pharmaceutics

Multidrug, Anti-HIV Amorphous Solid Dispersions: Nature and Mechanisms of Impacts of Drugs on Each Other’s Solution Concentrations
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2017, 14 (11), pp 3617–3627
DOI: 10.1021/acs.molpharmaceut.7b00203

Cleavable Multifunctional Targeting Mixed Micelles with Sequential pH-Triggered TAT Peptide Activation for Improved Antihepatocellular Carcinoma Efficacy
Mol. Pharmaceutics, 2017, 14 (11), pp 3644–3659
DOI: 10.1021/acs.molpharmaceut.7b00404

Reduction-sensitive Paclitaxel Prodrug Self-assembled Nanoparticles with Tetrandrine Effectively Promote Synergistic Therapy Against Drug-sensitive and Multidrug-resistant Breast Cancer
Mol. Pharmaceutics, 2017, 14 (11), pp 3628–3635
DOI: 10.1021/acs.molpharmaceut.7b00381

Lymphoma Immunochemotherapy: Targeted Delivery of Doxorubicin via a Dual Functional Nanocarrier
Mol. Pharmaceutics, 2017, 14 (11), pp 3888–3895
DOI: 10.1021/acs.molpharmaceut.7b00606

Receptor-Mediated Attachment and Uptake of Hyaluronan Conjugates by Breast Cancer Cells
Mol. Pharmaceutics, 2017, 14 (11), pp 3968–3977
DOI: 10.1021/acs.molpharmaceut.7b00636


Organic Letters

CITU: A Peptide and Decarboxylative Coupling Reagent
Org. Lett., 2017, 19 (22), pp 6196–6199
DOI: 10.1021/acs.orglett.7b03121

Co(OAc)2-Catalyzed Trifluoromethylation and C(3)-Selective Arylation of 2-(Propargylamino)pyridines via a 6-Endo-Dig Cyclization
Org. Lett., 2017, 19 (22), pp 6052–6055
DOI: 10.1021/acs.orglett.7b02759

Intermolecular Amidation of Quinoline N-Oxides with Arylsulfonamides under Metal-Free Conditions
Org. Lett., 2017, 19 (22), pp 6088–6091
DOI: 10.1021/acs.orglett.7b02922

N-Bromosuccinimide (NBS)-Catalyzed C–H Bond Functionalization: An Annulation of Alkynes with Electron Withdrawing Group (EWG)-Substituted Acetyl Indoles for the Synthesis of Carbazoles
Org. Lett., 2017, 19 (22), pp 6140–6143
DOI: 10.1021/acs.orglett.7b03021

Asymmetric Total Synthesis of (−)-Clovan-2,9-dione Using Rh(I)-Catalyzed [3 + 2 + 1] Cycloaddition of 1-Yne-vinylcyclopropane and CO
Org. Lett., 2017, 19 (22), pp 6040–6043
DOI: 10.1021/acs.orglett.7b02656


Organic Process Research & Development

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2017, 21 (11), pp 1695–1704
DOI: 10.1021/acs.oprd.7b00338

Practical Asymmetric Synthesis of a Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist Ubrogepant
Org. Process Res. Dev., 2017, 21 (11), pp 1851–1858
DOI: 10.1021/acs.oprd.7b00293

Match-Making Reactors to Chemistry: A Continuous Manufacturing-Enabled Sequence to a Key Benzoxazole Pharmaceutical Intermediate
Open access through ACS Editors’ Choice
Org. Process Res. Dev., 2017, 21 (11), pp 1779–1793
DOI: 10.1021/acs.oprd.7b00254

Synthetic Story of a Blockbuster Drug: Reboxetine, a Potent Selective Norepinephrine Reuptake Inhibitor
Org. Process Res. Dev., 2017, 21 (11), pp 1705–1731
DOI: 10.1021/acs.oprd.7b00265

Old is Gold? Nefopam Hydrochloride, a Non-opioid and Non-steroidal Analgesic Drug and Its Practical One-Pot Synthesis in a Single Solvent for Large-Scale Production
Org. Process Res. Dev., 2017, 21 (11), pp 1745–1751
DOI: 10.1021/acs.oprd.7b00228



Toxicity of Metal Compounds: Knowledge and Myths
Open Access Through ACS AuthorChoice
Organometallics, 2017, 36 (21), pp 4071–4090
DOI: 10.1021/acs.organomet.7b00605

C–H Activation of π-Arene Ruthenium Complexes
Organometallics, 2017, 36 (22), pp 4376–4381
DOI: 10.1021/acs.organomet.7b00563

Synthesis and Reactivity of Pyridine(diimine) Molybdenum Olefin Complexes: Ethylene Dimerization and Alkene Dehydrogenation
Organometallics, 2017, 36 (21), pp 4215–4223
DOI: 10.1021/acs.organomet.7b00653

Cobalt-Catalyzed Cross-Coupling Reactions of Arylboronic Esters and Aryl Halides
Organometallics, 2017, 36 (22), pp 4363–4366
DOI: 10.1021/acs.organomet.7b00726

Activation of Dioxygen by Dimethylplatinum(II) Complexes
Organometallics, 2017, 36 (21), pp 4169–4178
DOI: 10.1021/acs.organomet.7b00614











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