Discover the Most-Read Organic and Inorganic Chemistry Articles of January 2018

What were chemists reading in January of 2018? To find out, we’ve compiled lists of the five most-read chemistry articles that appeared in each organic and inorganic chemistry ACS Publications journal in January 2018, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journals’ editors. The lists also don’t take other factors, such as citations, into account. This article should not be taken as a “best of” compilation, but rather as an interesting perspective on where the chemistry community allocated their attention recently. Don’t see your favorite paper on the list? Include it in the comments below.

Read More Great January 2018 Chemistry Research:

Analytical Chemistry | Applied Chemistry | Biological Chemistry | Materials Science & Engineering | Multidisciplinary Chemistry | Physical Chemistry

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ACS Catalysis

Recent Advances in Radical-Initiated C(sp3)–H Bond Oxidative Functionalization of Alkyl Nitriles
Open Access Through ACS Editors’ Choice.
ACS Catal., 2018, 8 (1), pp 258–271
DOI: 10.1021/acscatal.7b03334

Axially Chiral P,N-Ligands: Some Recent Twists and Turns
Open Access Through ACS Editors’ Choice.
ACS Catal., 2018, 8 (1), pp 624–643
DOI: 10.1021/acscatal.7b03759

Amorphous Cobalt Vanadium Oxide as a Highly Active Electrocatalyst for Oxygen Evolution
Open Access Through ACS AuthorChoice.
ACS Catal., 2018, 8 (1), pp 644–650
DOI: 10.1021/acscatal.7b03198

Insights into Nitrate Reduction over Indium-Decorated Palladium Nanoparticle Catalysts
ACS Catal., 2018, 8 (1), pp 503–515
DOI: 10.1021/acscatal.7b01371

Ni(OH)2 Nanoparticles Embedded in Conductive Microrod Array: An Efficient and Durable Electrocatalyst for Alkaline Oxygen Evolution Reaction
ACS Catal. 2018, 8 (1), pp 651–655
DOI: 10.1021/acscatal.7b03406


ACS Combinatorial Science

Novel Multicomponent Synthesis of Pyridine–Pyrimidines and Their Bis-Derivatives Catalyzed by Triazine Diphosphonium Hydrogen Sulfate Ionic Liquid Supported on Functionalized Nanosilica
ACS Comb. Sci., 2018, 20 (1), pp 19–25
DOI: 10.1021/acscombsci.7b00079

An Old Story in the Parallel Synthesis World: An Approach to Hydantoin Libraries
ACS Comb. Sci., 2018, 20 (1), pp 35–43
DOI: 10.1021/acscombsci.7b00163

Application of High-Throughput Seebeck Microprobe Measurements on Thermoelectric Half-Heusler Thin Film Combinatorial Material Libraries
ACS Comb. Sci., 2018, 20 (1), pp 1–18
DOI: 10.1021/acscombsci.7b00019

Combinatorial Discovery of Lanthanum–Tantalum Oxynitride Solar Light Absorbers with Dilute Nitrogen for Solar Fuel Applications
ACS Comb. Sci., 2018, 20 (1), pp 26–34
DOI: 10.1021/acscombsci.7b00143

Issue Editorial Masthead
ACS Comb. Sci.,  2018, 20 (1)
DOI: 10.1021/cov020i001_1158677


ACS Medicinal Chemistry Letters

Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases
Open Access Through ACS Editors’ Choice.
ACS Med. Chem. Lett., 2018, 9 (1), pp 28–33
DOI: 10.1021/acsmedchemlett.7b00395

The Attack of the Smart Particles: Should Bacteria Be Afraid?
ACS Med. Chem. Lett., 2018, 9 (1), pp 2–3
DOI: 10.1021/acsmedchemlett.7b00455

Fluorescent Carbon Nanoparticles in Medicine for Cancer Therapy: An Update
ACS Med. Chem. Lett., 2018, 9 (1), pp 4–5
DOI: 10.1021/acsmedchemlett.7b00523

Synthesis of a Chloroalkene Dipeptide Isostere-Containing Peptidomimetic and Its Biological Application
ACS Med. Chem. Lett., 2018, 9 (1), pp 6–10
DOI: 10.1021/acsmedchemlett.7b00234

Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery
ACS Med. Chem. Lett., 2018, 9 (1), pp 34–38
DOI: 10.1021/acsmedchemlett.7b00414


Bioconjugate Chemistry

Imaging PD-L1 Expression with ImmunoPET
Open Access Through ACS AuthorChoice.
Bioconjugate Chem., 2018, 29 (1), pp 96–103
DOI: 10.1021/acs.bioconjchem.7b00631

A Molecular Rotor-Based Halo-Tag Ligand Enables a Fluorogenic Proteome Stress Sensor to Detect Protein Misfolding in Mildly Stressed Proteome
Bioconjugate Chem, 2018, 29 (1), pp 96–103
DOI: 10.1021/acs.bioconjchem.7b00763

Site-Specific Modification of Single-Chain Antibody Fragments for Bioconjugation and Vascular Immunotargeting
Bioconjugate Chem., 2018, 29 (1), pp 56–66
DOI: 10.1021/acs.bioconjchem.7b00592

Hyaluronic Acid-Based pH-Sensitive Polymer-Modified Liposomes for Cell-Specific Intracellular Drug Delivery Systems
Bioconjugate Chem., 2018, 29 (1), pp 44–55
DOI: 10.1021/acs.bioconjchem.7b00551

Chemoselective Dual Labeling of Native and Recombinant Proteins
Bioconjugate Chem., 2018, 29 (1), pp 29–34
DOI: 10.1021/acs.bioconjchem.7b00675


Inorganic Chemistry

Catalytic Performance of a Dicopper–Oxo Complex for Methane Hydroxylation
Open Access Through ACS Editors’ Choice.
Inorg. Chem., 2018, 57 (1), pp 8–11
DOI: 10.1021/acs.inorgchem.7b02563

New Year’s Resolutions
Inorg. Chem., 2018, 57 (1), pp 1–3
DOI: 10.1021/acs.inorgchem.7b03022

Controllable Fluorescence Switching of a Coordination Chain Based on the Photoinduced Single-Crystal-to-Single-Crystal Reversible Transformation of a syn-[2.2]Metacyclophane
Inorg. Chem.., 2018, 57 (2), pp 849–856
DOI: 10.1021/acs.inorgchem.7b02817

Systematic Doping of Cobalt into Layered Manganese Oxide Sheets Substantially Enhances Water Oxidation Catalysis
Inorg. Chem., 2018, 57 (2), pp 557–564
DOI: 10.1021/acs.inorgchem.7b01592

Elusive Scorpionates: C3-Symmetric, Formally Dianionic, Facially Tridentate Ligands
Inorg. Chem., 2018, 57 (2), pp 553–556
DOI: 10.1021/acs.inorgchem.7b02884


Journal of Medicinal Chemistry

Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?
This article is part of the Inducing Protein Degradation as a Therapeutic Strategy special issue.
J. Med. Chem., 2018, 61 (2), pp 444–452
DOI: 10.1021/acs.jmedchem.7b01272

Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors
Open Access Through ACS Editors’ Choice.
J. Med. Chem., 2018, 61 (1), pp 265–285
DOI: 10.1021/acs.jmedchem.7b01342

Inhibitors of HIV-1 Attachment: The Discovery and Development of Temsavir and its Prodrug Fostemsavir
J. Med. Chem., 2018, 61 (1), pp 62–80
DOI: 10.1021/acs.jmedchem.7b01337

Inducing Protein Degradation as a Therapeutic Strategy
This article is part of the Inducing Protein Degradation as a Therapeutic Strategy special issue.
J. Med. Chem., 2018, 61 (2), pp 403–404
DOI: 10.1021/acs.jmedchem.7b01333

Recent Advances in Structure-Based Drug Design Targeting Class A G Protein-Coupled Receptors Utilizing Crystal Structures and Computational Simulations
Open Access Through ACS AuthorChoice.
J. Med. Chem., 2018, 61 (1), pp 1–46
DOI: 10.1021/acs.jmedchem.6b01453


Journal of Natural Products

Keikipukalides, Furanocembrane Diterpenes from the Antarctic Deep Sea Octocoral Plumarella delicatissima
Open Access Through ACS AuthorChoice.
J. Nat. Prod., 2018, 81 (1), pp 117–123
DOI: 10.1021/acs.jnatprod.7b00732

Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group
J. Nat. Prod., 2018, 81 (1), pp 211–215
DOI: 10.1021/acs.jnatprod.7b00917

Anti-Inflammatory Prenylated Phenylpropenols and Coumarin Derivatives from Murraya exotica
J. Nat. Prod., 2018, 81 (1), pp 22–33
DOI: 10.1021/acs.jnatprod.7b00518

Ophiobolins from the Mangrove Fungus Aspergillus ustus
J. Nat. Prod., 2018, 81 (1), pp 2–9
DOI: 10.1021/acs.jnatprod.7b00335

Identification and Proposed Relative and Absolute Configurations of Niphimycins C–E from the Marine-Derived Streptomyces sp. IMB7-145 by Genomic Analysis
J. Nat. Prod., 2018, 81 (1), pp 178–187
DOI: 10.1021/acs.jnatprod.7b00859


The Journal of Organic Chemistry

Regioselective Halogenation of Arenes and Heterocycles in Hexafluoroisopropanol
J. Org. Chem., 2018, 83 (2), pp 930–938
DOI: 10.1021/acs.joc.7b02920

Modular Three-Component Synthesis of 4-Aminoquinolines via an Imidoylative Sonogashira/Cyclization Cascade
Open Access Through ACS AuthorChoice.
J. Org. Chem., 2018, 83 (2), pp 854–861
DOI: 10.1021/acs.joc.7b02844

Formal Total Syntheses of (−)- and (+)-Actinophyllic Acid
J. Org. Chem., 2018, 83 (2), pp 754–764
DOI: 10.1021/acs.joc.7b02747

Tropylium-Promoted Oxidative Functionalization of Tetrahydroisoquinolines
J. Org. Chem., 2018, 83 (2), pp 1000–1010
DOI: 10.1021/acs.joc.7b02584

Metal-Free Synthesis of Unsymmetrical Ureas and Carbamates from CO2 and Amines via Isocyanate Intermediates
J. Org. Chem., 2018, 83 (2), pp 913–920
DOI: 10.1021/acs.joc.7b02905


Molecular Pharmaceutics

Solid-State Hydrogen–Deuterium Exchange Mass Spectrometry: Correlation of Deuterium Uptake and Long-Term Stability of Lyophilized Monoclonal Antibody Formulations
Mol. Pharmaceutics,, 2018, 15 (1), pp 1–11
DOI: 10.1021/acs.molpharmaceut.7b00504

Cyclic versus Noncyclic Chelating Scaffold for 89Zr-Labeled ZEGFR:2377 Affibody Bioconjugates Targeting Epidermal Growth Factor Receptor Overexpression
Open Access Through ACS AuthorChoice.
Mol. Pharmaceutics, 2018, 15 (1), pp 1–11
DOI: 10.1021/acs.mlpharmaceut.7b00787

Nucleolin-Targeting AS1411-Aptamer-Modified Graft Polymeric Micelle with Dual pH/Redox Sensitivity Designed To Enhance Tumor Therapy through the Codelivery of Doxorubicin/TLR4 siRNA and Suppression of Invasion
Mol. Pharmaceutics, 2018, 15 (1), pp 314–325
DOI: 10.1021/acs.molpharmaceut.7b01093

Tm-Values and Unfolded Fraction Can Predict Aggregation Rates for Granulocyte Colony Stimulating Factor Variant Formulations but Not under Predominantly Native Conditions
Open Access Through ACS AuthorChoice.
Mol. Pharmaceutics, 2018, 15 (1), pp 256–267
DOI: 10.1021/acs.molpharmaceut.7b00876

pPB Peptide-Mediated siRNA-Loaded Stable Nucleic Acid Lipid Nanoparticles on Targeting Therapy of Hepatic Fibrosis
Mol. Pharmaceutics, 2018, 15 (1), pp 53–62
DOI: 10.1021/acs.molpharmaceut.7b00709


Organic Letters

Photoredox-Catalyzed Decarboxylative Alkylation of Silyl Enol Ethers To Synthesize Functionalized Aryl Alkyl Ketones
Org. Lett., 2018, 20 (2), pp 349–352
DOI: 10.1021/acs.orglett.7b03587

Catalytic Ester to Stannane Functional Group Interconversion via Decarbonylative Cross-Coupling of Methyl Esters
Org. Lett.
DOI: 10.1021/acs.orglett.7b03669

Enantioselective Total Synthesis of Cannabinoids—A Route for Analogue Development
Org. Lett., 2018, 20 (2), pp 385–388
DOI: 10.1021/acs.orglett.7b03668

Dual Photoredox/Nickel-Catalyzed Regioselective Cross-Coupling of 2-Arylaziridines and Potassium Benzyltrifluoroborates: Synthesis of β-Substitued Amines
Org. Lett., 2018, 20 (2), pp 421–424
DOI: 10.1021/acs.orglett.7b03747

Copper-Catalyzed Radical Difluoroalkylation and Redox Annulation of Nitroalkynes for the Construction of C2-Tetrasubstituted Indolin-3-ones
Org. Lett., 2018, 20 (2), pp 393–396
DOI: 10.1021/acs.orglett.7b03678


Organic Process Research & Development

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2018, 22 (1), pp 1–12
DOI: 10.1021/acs.oprd.7b00390

Applications of Flow Chemistry in Drug Development: Highlights of Recent Patent Literature
Org. Process Res. Dev., 2018, 22 (1), pp 13–20
DOI: 10.1021/acs.oprd.7b00363

Enabling the Multigram Synthesis of (2-Cyclooctyn-1-yloxy)acetic Acid
Org. Process Res. Dev., 2018, 22 (1), pp 108–110
DOI: 10.1021/acs.oprd.7b00275

Catalytic Enantioselective Synthesis of Key Propargylic Alcohol Intermediates of the Anti-HIV Drug Efavirenz
Org. Process Res. Dev., 2018, 22 (1), pp 103–107
DOI: 10.1021/acs.oprd.7b00376

Identification and Elimination of an Unexpected Catalyst Poison in Suzuki Coupling
Org. Process Res. Dev., 2018, 22 (1), pp 111–116
DOI: 10.1021/acs.oprd.7b00342



A Universally Applicable Methodology for the Gram-Scale Synthesis of Primary, Secondary, and Tertiary Phosphine
Organometallics, 2018, 37 (2), pp 182–190
DOI: 10.1021/acs.organomet.7b0068

An Improved Synthesis of Me4PCP and DMPE
Organometallics, 2018, 37 (2), pp 211–213
DOI: 10.1021/acs.organomet.7b00780

Developing Bis(imino)acenaphthene-Supported N-Heterocyclic Carbene Palladium Precatalysts for Direct Arylation of Azoles
Organometallics, 2018, 37 (2), pp 214–226
DOI: 10.1021/acs.organomet.7b00784

1,2-CH Bond Activation of Pyridine across a Transient Titanium Alkylidene Radical and Re-Formation of the Ti═CHtBu Moiety
Organometallics, 2018, 37 (2), pp 165–167
DOI: 10.1021/acs.organomet.7b00770

Quantifying Structural Effects of Amino Acid Ligands in Pd(II)-Catalyzed Enantioselective C–H Functionalization Reactions
Organometallics, 2018, 37 (2), pp 203–210
DOI: 10.1021/acs.organomet.7b00751



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