There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five […]
There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in February 2018, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.
Read more of February’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Physical
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ACS Catalysis
Advances in Direct Metal-Catalyzed Functionalization of Azobenzenes
ACS Catal., 2018, 8 (2), pp 1546–1579
DOI: 10.1021/acscatal.7b03583
Carbon Modification of Nickel Catalyst for Depolymerization of Oxidized Lignin to Aromatics
ACS Catal., 2018, 8 (2), pp 1614–1620
DOI: 10.1021/acscatal.7b03475
Direct Synthesis of H2O2 from H2 and O2 on Pd Catalysts: Current Understanding, Outstanding Questions, and Research Needs
ACS Catal., 2018, 8 (2), pp 1520–1527
DOI: 10.1021/acscatal.7b04107
Dual Role of a Photocatalyst: Generation of Ni(0) Catalyst and Promotion of Catalytic C–N Bond Formation
ACS Catal., 2018, 8 (2), pp 1456–1463
DOI: 10.1021/acscatal.7b03024
Facile Ammonia Synthesis from Electrocatalytic N2 Reduction under Ambient Conditions on N-Doped Porous Carbon
ACS Catal., 2018, 8 (2), pp 1186–1191
DOI: 10.1021/acscatal.7b02165
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ACS Combinatorial Science
Application of the Open qPCR Instrument for the in Vitro Selection of DNA Aptamers against Epidermal Growth Factor Receptor and Drosophila C Virus
ACS Comb. Sci., 2018, 20 (2), pp 45–54
DOI: 10.1021/acscombsci.7b00138
Construction of 1,3,4-Oxadiazole and 1,3,4-Thiadiazole Library with a High Level of Skeletal Diversity Based on Branching Diversity-Oriented Synthesis on Solid-Phase Supports
ACS Comb. Sci., 2018, 20 (2), pp 82–97
DOI: 10.1021/acscombsci.7b00174
Discrete Fourier Transform-Based Multivariate Image Analysis: Application to Modeling of Aromatase Inhibitory Activity
ACS Comb. Sci., 2018, 20 (2), pp 75–81
DOI: 10.1021/acscombsci.7b00155
DNA-Compatible Solid-Phase Combinatorial Synthesis of β-Cyanoacrylamides and Related Electrophiles
ACS Comb. Sci., 2018, 20 (2), pp 61–69
DOI: 10.1021/acscombsci.7b00169
Issue Editorial Masthead
ACS Comb. Sci., 2018, 20 (2),
DOI: 10.1021/cov020i002_1166646
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Click-Addressable Cassette for Photoaffinity Labeling
ACS Med. Chem. Lett., 2018, 9 (2), pp 155–158
DOI: 10.1021/acsmedchemlett.7b00516
Discovery and in Vitro Optimization of 3-Sulfamoylbenzamides as ROMK Inhibitors
ACS Med. Chem. Lett., 2018, 9 (2), pp 125–130
DOI: 10.1021/acsmedchemlett.7b00481
Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin’s Lymphoma
ACS Med. Chem. Lett., 2018, 9 (2), pp 98–102
DOI: 10.1021/acsmedchemlett.7b00437
From RORγt Agonist to Two Types of RORγt Inverse Agonists
ACS Med. Chem. Lett., 2018, 9 (2), pp 120–124
DOI: 10.1021/acsmedchemlett.7b00476
Identification of Potent Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors Based on a Phenylimidazole Scaffold
ACS Med. Chem. Lett., 2018, 9 (2), pp 131–136
DOI: 10.1021/acsmedchemlett.7b00488
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Bioconjugate Chemistry
a-Factor Analogues Containing Alkyne- and Azide-Functionalized Isoprenoids Are Efficiently Enzymatically Processed and Retain Wild-Type Bioactivity
Open Access Through ACS AuthorChoice
Bioconjugate Chem., 2018, 29 (2), pp 316–323
DOI: 10.1021/acs.bioconjchem.7b00648
Bioorthogonal Masking of Circulating Antibody–TCO Groups Using Tetrazine-Functionalized Dextran Polymers
Bioconjugate Chem., 2018, 29 (2), pp 538–545
DOI: 10.1021/acs.bioconjchem.8b00028
CRISPRed Macrophages for Cell-Based Cancer Immunotherapy
Bioconjugate Chem., 2018, 29 (2), pp 445–450
DOI: 10.1021/acs.bioconjchem.7b00768
High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers
Bioconjugate Chem., 2018, 29 (2), pp 473–485
DOI: 10.1021/acs.bioconjchem.7b00791
Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody–Drug Conjugates with Phenol-Containing Payloads
Bioconjugate Chem., 2018, 29 (2), pp 267–274
DOI: 10.1021/acs.bioconjchem.7b00576
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Inorganic Chemistry
Coumarin Derivative Directly Coordinated to Lanthanides Acts as an Excellent Antenna for UV–Vis and Near-IR Emission
Inorg. Chem., 2018, 57 (3), pp 908–911
DOI: 10.1021/acs.inorgchem.7b02861
Fluorescent Metal–Organic Framework (MOF) as a Highly Sensitive and Quickly Responsive Chemical Sensor for the Detection of Antibiotics in Simulated Wastewater
Inorg. Chem., 2018, 57 (3), pp 1060–1065
DOI: 10.1021/acs.inorgchem.7b02471
General Strategy for Rapid Production of Low-Dimensional All-Inorganic CsPbBr3 Perovskite Nanocrystals with Controlled Dimensionalities and Sizes
Inorg. Chem., 2018, 57 (3), pp 1598–1603
DOI: 10.1021/acs.inorgchem.7b02941
Glucose-Appended Platinum(II)-BODIPY Conjugates for Targeted Photodynamic Therapy in Red Light
Inorg. Chem., 2018, 57 (4), pp 1717–1726
DOI: 10.1021/acs.inorgchem.7b02249
Influences of Bifunctional PNP-Pincer Ligands on Low Valent Cobalt Complexes Relevant to CO2 Hydrogenation
Inorg. Chem., 2018, 57 (3), pp 1590–1597
DOI: 10.1021/acs.inorgchem.7b02931
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Journal of Medicinal Chemistry
Allosteric Modulators of Drug Targets Special Issue
J. Med. Chem., 2018, 61 (4), pp 1381–1381
DOI: 10.1021/acs.jmedchem.8b00171
BACE-1 Inhibitors: From Recent Single-Target Molecules to Multitarget Compounds for Alzheimer’s Disease
J. Med. Chem., 2018, 61 (3), pp 619–637
DOI: 10.1021/acs.jmedchem.7b00393
Discovery of Potent and Orally Bioavailable Dihydropyrazole GPR40 Agonists
J. Med. Chem., 2018, 61 (3), pp 681–694
DOI: 10.1021/acs.jmedchem.7b00982
Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo
Open Access Through ACS Editors’ Choice
J. Med. Chem., 2018, 61 (3), pp 865–880
DOI: 10.1021/acs.jmedchem.7b01371
Free Energy Methods in Drug Design: Prospects of “Alchemical Perturbation” in Medicinal Chemistry
J. Med. Chem., 2018, 61 (3), pp 638–649
DOI: 10.1021/acs.jmedchem.7b00681
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Journal of Natural Products
Cybastacines A and B: Antibiotic Sesterterpenes from a Nostoc sp. Cyanobacterium
J. Nat. Prod., 2018, 81 (2), pp 410–413
DOI: 10.1021/acs.jnatprod.7b00638
Cyclizidine-Type Alkaloids from Streptomyces sp. HNA39
J. Nat. Prod., 2018, 81 (2), pp 394–399
DOI: 10.1021/acs.jnatprod.7b01055
Hamigerans R and S: Nitrogenous Diterpenoids from the New Zealand Marine Sponge Hamigera tarangaensis
J. Nat. Prod., 2018, 81 (2), pp 387–393
DOI: 10.1021/acs.jnatprod.7b00960
Lipovelutibols A–D: Cytotoxic Lipopeptaibols from the Himalayan Cold Habitat Fungus Trichoderma velutinum
J. Nat. Prod., 2018, 81 (2), pp 219–226
DOI: 10.1021/acs.jnatprod.6b00873
Metabolomics-Guided Discovery of Microginin Peptides from Cultures of the Cyanobacterium Microcystis aeruginosa
J. Nat. Prod., 2018, 81 (2), pp 349–355
DOI: 10.1021/acs.jnatprod.7b00829
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The Journal of Organic Chemistry
N,O π-Conjugated 4-Substituted 1,3-Thiazole BF2 Complexes: Synthesis and Photophysical Properties
J. Org. Chem., 2018, 83 (3), pp 1095–1105
DOI: 10.1021/acs.joc.7b02239
Cascade Synthesis of 3-Functionalized Indoles from Nitrones and Their Conversion to Cycloheptanone-Fused Indoles
J. Org. Chem., 2018, 83 (3), pp 1085–1094
DOI: 10.1021/acs.joc.7b02638
Chemoselective Reduction of Sterically Demanding N,N-Diisopropylamides to Aldehydes
J. Org. Chem., 2018, 83 (4), pp 1687–1700
DOI: 10.1021/acs.joc.7b02868
Green-Light-Sensitive BODIPY Photoprotecting Groups for Amines
Open Access Through ACS AuthorChoice
J. Org. Chem., 2018, 83 (4), pp 1819–1827
DOI: 10.1021/acs.joc.7b02729
Iron-Catalyzed Batch/Continuous Flow C–H Functionalization Module for the Synthesis of Anticancer Peroxides
J. Org. Chem., 2018, 83 (3), pp 1358–1368
DOI: 10.1021/acs.joc.7b02854
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Molecular Pharmaceutics
ATP-Binding Cassette Transporter A Subfamily 8 Is a Sinusoidal Efflux Transporter for Cholesterol and Taurocholate in Mouse and Human Liver
Mol. Pharmaceutics, 2018, 15 (2), pp 343–355
DOI: 10.1021/acs.molpharmaceut.7b00679
Comparison of the Expression Kinetics and Immunostimulatory Activity of Replicating mRNA, Nonreplicating mRNA, and pDNA after Intradermal Electroporation in Pigs
Mol. Pharmaceutics, 2018, 15 (2), pp 377–384
DOI: 10.1021/acs.molpharmaceut.7b00722
Difluoromethylornithine Combined with a Polyamine Transport Inhibitor Is Effective against Gemcitabine Resistant Pancreatic Cancer
Mol. Pharmaceutics, 2018, 15 (2), pp 369–376
DOI: 10.1021/acs.molpharmaceut.7b00718
Facile Deposition of Manganese Dioxide to Albumin-Bound Paclitaxel Nanoparticles for Modulation of Hypoxic Tumor Microenvironment To Improve Chemoradiation Therapy
Mol. Pharmaceutics, 2018, 15 (2), pp 447–457
DOI: 10.1021/acs.molpharmaceut.7b00808
Metal Protein-Attenuating Compound for PET Neuroimaging: Synthesis and Preclinical Evaluation of [11C]PBT2
Mol. Pharmaceutics, 2018, 15 (2), pp 695–702
DOI: 10.1021/acs.molpharmaceut.7b00936
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Organic Letters
Asymmetric and Site-Selective [3 + 2]-Annulations for the Synthesis of High-Value Bicyclic Lactams
Open Access Through ACS Editors’ Choice
Org. Lett., 2018, 20 (4), pp 1146–1149
DOI: 10.1021/acs.orglett.8b00076
Biomimetic Enantioselective Total Synthesis of (−)-Petromindole
Org. Lett., 2018, 20 (3), pp 632–635
DOI: 10.1021/acs.orglett.7b03768
Copper-Catalyzed Diamination of Alkenes of Unsaturated Ketohydrazones with Amines
Org. Lett., 2018, 20 (3), pp 510–513
DOI: 10.1021/acs.orglett.7b03401
Dehydration of Amides to Nitriles under Conditions of a Catalytic Appel Reaction
Org. Lett., 2018, 20 (3), pp 728–731
DOI: 10.1021/acs.orglett.7b03862
Direct Catalytic Asymmetric Mannich-Type Reaction en Route to α-Hydroxy-β-amino Acid Derivatives
Open Access Through ACS Editors’ Choice
Org. Lett., 2018, 20 (3), pp 526–529
DOI: 10.1021/acs.orglett.7b03609
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Organic Process Research & Development
Concise Synthesis of Versatile Imidazo[5,1-f][1,2,4]triazin-4(3H)-ones
Org. Process Res. Dev., 2018, 22 (2), pp 166–172
DOI: 10.1021/acs.oprd.7b00333
Continuous-Flow In-Line Solvent-Swap Crystallization of Vitamin D3
Open Access Through ACS AuthorChoice
Org. Process Res. Dev., 2018, 22 (2), pp 178–189
DOI: 10.1021/acs.oprd.7b00351
Development and Scale-Up of a Manufacturing Route for the Non-nucleoside Reverse Transcriptase Inhibitor GSK2248761A (IDX-899): Synthesis of an Advanced Key Chiral Intermediate
Org. Process Res. Dev., 2018, 22 (2), pp 200–206
DOI: 10.1021/acs.oprd.7b00356
Evaluation of Starting Materials for PMIs (Potentially Mutagenic Impurities): A Vortioxetine Case Study
Org. Process Res. Dev., 2018, 22 (2), pp 125–135
DOI: 10.1021/acs.oprd.7b00239
Microflow High-p,T Intensification of Vitamin D3 Synthesis Using an Ultraviolet Lamp
Open Access Through ACS AuthorChoice
Org. Process Res. Dev., 2018, 22 (2), pp 147–155
DOI: 10.1021/acs.oprd.7b00318
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Organometallics
Activation of Carbon–Hydrogen Bonds via 1,2-RH-Addition/-Elimination to Early Transition Metal Imides
Organometallics, 2018, 37 (4), pp 505–516
DOI: 10.1021/acs.organomet.7b00753
CO2 Reduction Pathways on MnBr(N-C)(CO)3 Electrocatalysts
Organometallics, 2018, 37 (3), pp 337–342
DOI: 10.1021/acs.organomet.7b00743
Cooperative Metal + Ligand Oxidative Addition and σ-Bond Metathesis: A DFT Study
Organometallics, 2018, 37 (3), pp 309–313
DOI: 10.1021/acs.organomet.7b00715
Iridium and Rhodium Complexes Containing Enantiopure Primary Amine-Tethered N-Heterocyclic Carbenes: Synthesis, Characterization, Reactivity, and Catalytic Asymmetric Hydrogenation of Ketones
Organometallics, 2018, 37 (3), pp 491–504
DOI: 10.1021/acs.organomet.7b00915
Iron(II)-Catalyzed Hydrogenation of Acetophenone with a Chiral, Pyridine-Based PNP Pincer Ligand: Support for an Outer-Sphere Mechanism
Organometallics, 2018, 37 (3), pp 396–405
DOI: 10.1021/acs.organomet.7b00816