There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five […]
There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in April 2018, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.
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Read more of April’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Physical
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ACS Catalysis
Challenges and Prospects in Solar Water Splitting and CO2 Reduction with Inorganic and Hybrid Nanostructures
ACS Catal., 2018, 8 (4), pp 3602–3635
DOI: 10.1021/acscatal.8b00791
Anion-Containing Noble-Metal-Free Bifunctional Electrocatalysts for Overall Water Splitting
ACS Catal., 2018, 8 (4), pp 3688–3707
DOI: 10.1021/acscatal.7b04286
Trends in the Catalytic Activity of Hydrogen Evolution during CO2 Electroreduction on Transition Metals
ACS Catal., 2018, 8 (4), pp 3035–3040
DOI: 10.1021/acscatal.7b03807
Cooperation between holey graphene and NiMo alloy for hydrogen evolution in an acidic electrolyte
ACS Catal., 2018, 8 (4), pp 3579–3586
DOI: 10.1021/acscatal.7b04091
Palladium-Catalyzed Synthesis of Diaryl Ketones from Aldehydes and (Hetero)Aryl Halides via C–H Bond Activation
ACS Catal., 2018, 8 (4), pp 3123–3128
DOI: 10.1021/acscatal.8b00440
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ACS Combinatorial Science
Synthesis of Highly Substituted Imidazole Uracil Containing Molecules via Ugi-4CR and Passerini-3CR
Open access through ACS AuthorChoice
ACS Comb. Sci., 2018, 20 (4), pp 192–196
DOI: 10.1021/acscombsci.7b00145
Comparison of Cell Permeability of Cyclic Peptoids and Linear Peptoids
ACS Comb. Sci., 2018, 20 (4), pp 237–242
DOI: 10.1021/acscombsci.7b00194
Solid-Phase Synthesis of Pyrrole Derivatives through a Multicomponent Reaction Involving Lys-Containing Peptides
ACS Comb. Sci., 2018, 20 (4), pp 187–191
DOI: 10.1021/acscombsci.8b00006
A General Small-Angle X-ray Scattering-Based Screening Protocol Validated for Protein–RNA Interactions
Open access through ACS AuthorChoice
ACS Comb. Sci., 2018, 20 (4), pp 197–202
DOI: 10.1021/acscombsci.8b00007
Synthesis of Cyclic Peptides as Potential Anti-Malarials
ACS Comb. Sci., 2018, 20 (4), pp 212–219
DOI: 10.1021/acscombsci.7b00154
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ACS Medicinal Chemistry Letters
Discovery of AG-120 (Ivosidenib): A First-in-Class Mutant IDH1 Inhibitor for the Treatment of IDH1 Mutant Cancers
Open access through ACS AuthorChoice
ACS Med. Chem. Lett., 2018, 9 (4), pp 300–305
DOI: 10.1021/acsmedchemlett.7b00421
Discovery of Novel Indoleamine 2,3-Dioxygenase 1 (IDO1) and Histone Deacetylase (HDAC) Dual Inhibitors
ACS Med. Chem. Lett., 2018, 9 (4), pp 312–317
DOI: 10.1021/acsmedchemlett.7b00487
Azabicyclic Fused Pyrimidine Derivatives Useful for the Treatment of Alzheimer’s Disease
ACS Med. Chem. Lett., 2018, 9 (4), pp 290–291
DOI: 10.1021/acsmedchemlett.8b00086
Modulating ADME Properties by Fluorination: MK2 Inhibitors with Improved Oral Exposure
ACS Med. Chem. Lett., 2018, 9 (4), pp 392–396
DOI: 10.1021/acsmedchemlett.8b00098
ATR Inhibitors as Potential Treatment for Cancers
ACS Med. Chem. Lett., 2018, 9 (4), pp 292–293
DOI: 10.1021/acsmedchemlett.8b00107
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Bioconjugate Chemistry
Advances in Polymer Design for Enhancing Oral Drug Solubility and Delivery
Bioconjugate Chem., 2018, 29 (4), pp 939–952
DOI: 10.1021/acs.bioconjchem.7b00646
Intracellular Peptide Self-Assembly: A Biomimetic Approach for in Situ Nanodrug Preparation
This article is part of the Biomimetic Materials special issue.
Bioconjugate Chem., 2018, 29 (4), pp 826–837
DOI: 10.1021/acs.bioconjchem.7b00798
Modulating Antibody–Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification
Bioconjugate Chem., 2018, 29 (4), pp 1155–1167
DOI: 10.1021/acs.bioconjchem.7b00785
A Fluorescent Probe for Stimulated Emission Depletion Super-Resolution Imaging of Vicinal-Dithiol-Proteins on Mitochondrial Membrane
Bioconjugate Chem., 2018, 29 (4), pp 1446–1453
DOI: 10.1021/acs.bioconjchem.8b00128
Vinylboronic Acids as Efficient Bioorthogonal Reactants for Tetrazine Labeling in Living Cells
Open access through ACS AuthorChoice
Bioconjugate Chem., 2018, 29 (4), pp 982–986
DOI: 10.1021/acs.bioconjchem.7b00796
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Inorganic Chemistry
Women in Inorganic Chemistry: Synthetic Chemistry Addressing Challenges in Energy and the Environment
Inorg. Chem., 2018, 57 (7), pp 3656–3658
DOI: 10.1021/acs.inorgchem.8b00532
Chemical Transformations in Confined Space of Coordination Architectures
Inorg. Chem., 2018, 57 (8), pp 4205–4221
DOI: 10.1021/acs.inorgchem.7b03067
Strategies To Assemble Catenanes with Multiple Interlocked Macrocycles
This article is part of the Self-Assembled Cages and Macrocycles special issue.
Inorg. Chem., 2018, 57 (7), pp 3475–3485
DOI: 10.1021/acs.inorgchem.7b02523
Rings and Things: The Magic of Building Self-Assembled Cages and Macrocycles
This article is part of the Self-Assembled Cages and Macrocycles special issue.
Inorg. Chem., 2018, 57 (7), pp 3497–3499
DOI: 10.1021/acs.inorgchem.8b00553
Coupling Metaloid-Directed Self-Assembly and Dynamic Covalent Systems as a Route to Large Organic Cages and Cyclophanes
This article is part of the Self-Assembled Cages and Macrocycles special issue.
Inorg. Chem., 2018, 57 (7), pp 3486–3496
DOI: 10.1021/acs.inorgchem.7b02716
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Journal of Medicinal Chemistry
Beyond the Rule of 5: Lessons Learned from AbbVie’s Drugs and Compound Collection
J. Med. Chem., 2018, 61 (7), pp 2636–2651
DOI: 10.1021/acs.jmedchem.7b00717
Fragment-Based Approach to Targeting Inosine-5′-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis
Open access through ACS AuthorChoice
J. Med. Chem., 2018, 61 (7), pp 2806–2822
DOI: 10.1021/acs.jmedchem.7b01622
Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer
J. Med. Chem., 2018, 61 (7), pp 2837–2864
DOI: 10.1021/acs.jmedchem.7b01682
Small-Molecule Activator of UNC-51-Like Kinase 1 (ULK1) That Induces Cytoprotective Autophagy for Parkinson’s Disease Treatment
J. Med. Chem., 2018, 61 (7), pp 2776–2792
DOI: 10.1021/acs.jmedchem.7b01575
Structure-Based Discovery and Optimization of Benzo[d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC)
J. Med. Chem., 2018, 61 (7), pp 3037–3058
DOI: 10.1021/acs.jmedchem.8b00103.
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Journal of Natural Products
Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation
Open access through ACS Editors’ Choice
J. Nat. Prod., 2018, 81 (4), pp 758–767
DOI: 10.1021/acs.jnatprod.7b00737
Isolation, Characterization, and Structure–Activity Relationship Analysis of Abietane Diterpenoids from Callicarpa bodinieri as Spleen Tyrosine Kinase Inhibitors
J. Nat. Prod., 2018, 81 (4), pp 998–1006
DOI: 10.1021/acs.jnatprod.7b01082
Absolute Configuration and Pharmacology of the Poison Frog Alkaloid Phantasmidine
J. Nat. Prod., 2018, 81 (4), pp 1029–1035
DOI: 10.1021/acs.jnatprod.8b00062
Total Synthesis of (±)-Minfiensine via a Formal [3+2] Cycloaddition
J. Nat. Prod., 2018, 81 (4), pp 1065–1069
DOI: 10.1021/acs.jnatprod.7b00873
Trichorenins A–C, Algicidal Tetracyclic Metabolites from the Marine-Alga-Epiphytic Fungus Trichoderma virens Y13-3
J. Nat. Prod., 2018, 81 (4), pp 1121–1124
DOI: 10.1021/acs.jnatprod.8b00164
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The Journal of Organic Chemistry
Synthesis and Explosion Hazards of 4-Azido-l-phenylalanine
J. Org. Chem., 2018, 83 (8), pp 4525–4536
DOI: 10.1021/acs.joc.8b00270
Copper-Catalyzed Chan–Lam Cyclopropylation of Phenols and Azaheterocycles
J. Org. Chem., 2018, 83 (7), pp 3417–3425
DOI: 10.1021/acs.joc.7b03100
An Enantioselective Total Synthesis of (+)-Duocarmycin SA
J. Org. Chem., 2018, 83 (7), pp 3928–3940
DOI: 10.1021/acs.joc.8b00285
Development of a Unified Enantioselective, Convergent Synthetic Approach Toward the Furanobutenolide-Derived Polycyclic Norcembranoid Diterpenes: Asymmetric Formation of the Polycyclic Norditerpenoid Carbocyclic Core by Tandem Annulation Cascade
J. Org. Chem., 2018, 83 (7), pp 3467–3485
DOI: 10.1021/acs.joc.7b02825
Palladium-Catalyzed Decarboxylative ortho-Amidation of Indole-3-carboxylic Acids with Isothiocyanates Using Carboxyl as a Deciduous Directing Group
J. Org. Chem., 2018, 83 (8), pp 4375–4383
DOI: 10.1021/acs.joc.8b00042
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Molecular Pharmaceutics
Liposomal Codelivery of Doxorubicin and Andrographolide Inhibits Breast Cancer Growth and Metastasis
Mol. Pharmaceutics, 2018, 15 (4), pp 1618–1626
DOI: 10.1021/acs.molpharmaceut.7b01164
pH-Responsive Nanophotosensitizer for an Enhanced Photodynamic Therapy of Colorectal Cancer Overexpressing EGFR
Mol. Pharmaceutics, 2018, 15 (4), pp 1432–1444
DOI: 10.1021/acs.molpharmaceut.7b00925
A New Method of Constructing a Drug–Polymer Temperature–Composition Phase Diagram Using Hot-Melt Extrusion
Mol. Pharmaceutics, 2018, 15 (4), pp 1379–1391
DOI: 10.1021/acs.molpharmaceut.7b00445
In Vitro, in Silico, and in Vivo Assessments of Intestinal Precipitation and Its Impact on Bioavailability of a BCS Class 2 Basic Compound
Mol. Pharmaceutics, 2018, 15 (4), pp 1607–1617
DOI: 10.1021/acs.molpharmaceut.7b01143
Evaluation of an Anti-HER2 Nanobody Labeled with 225Ac for Targeted α-Particle Therapy of Cancer
Mol. Pharmaceutics, 2018, 15 (4), pp 1457–1466
DOI: 10.1021/acs.molpharmaceut.7b00985
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Organic Letters
Multicomponent Oxidative Trifluoromethylation of Alkynes with Photoredox Catalysis: Synthesis of α-Trifluoromethyl Ketones
Org. Lett., 2018, 20 (7), pp 1693–1697
DOI: 10.1021/acs.orglett.8b00410
An Isolable and Bench-Stable Epoxidizing Reagent Based on Triazine: Triazox
Org. Lett., 2018, 20 (7), pp 2015–2019
DOI: 10.1021/acs.orglett.8b00560
Direct Dehydrogenative Arylation of Benzaldehydes with Arenes Using Transient Directing Groups
Org. Lett., 2018, 20 (7), pp 1794–1797
DOI: 10.1021/acs.orglett.8b00292
Total Synthesis of Sinensilactam A
Org. Lett., 2018, 20 (7), pp 1857–1860
DOI: 10.1021/acs.orglett.8b00380
Photoredox-Catalyzed Trifluoromethylative Intramolecular Cyclization: Synthesis of CF3-Containing Heterocyclic Compounds
Org. Lett., 2018, 20 (7), pp 1698–1702
DOI: 10.1021/acs.orglett.8b00648
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Organic Process Research & Development
Recent Developments in the Reduction of Aromatic and Aliphatic Nitro Compounds to Amines
Org. Process Res. Dev., 2018, 22 (4), pp 430–445
DOI: 10.1021/acs.oprd.6b00205
Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2018, 22 (4), pp 421–429
DOI: 10.1021/acs.oprd.8b00091
N-Butylpyrrolidinone as Alternative Solvent for Solid-Phase Peptide Synthesis
Open access through ACS Editors’ Choice
Org. Process Res. Dev., 2018, 22 (4), pp 494–503
DOI: 10.1021/acs.oprd.7b00389
Photoredox Iridium–Nickel Dual-Catalyzed Decarboxylative Arylation Cross-Coupling: From Batch to Continuous Flow via Self-Optimizing Segmented Flow Reactor
Org. Process Res. Dev., 2018, 22 (4), pp 542–550
DOI: 10.1021/acs.oprd.8b00018
Synthetic Strategies toward SGLT2 Inhibitors
Open access through ACS AuthorChoice
Org. Process Res. Dev., 2018, 22 (4), pp 467–488
DOI: 10.1021/acs.oprd.8b00017
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Organometallics
Comparison of the Reactivity of the Low Buried-Volume Carbene Complexes (ITMe)2Pd(PhC≡CPh) and (ITMe)2Pd(PhN═NPh)
Open access through ACS AuthorChoice
Organometallics, 2018, 37 (7), pp 1214–1218
DOI: 10.1021/acs.organomet.8b00112
Retraction of “A 1,2-Dicarbadodecaborane(12)-1,2-Dithiolate Chelating Ruthenium Carbene Catalyst for Highly Z Selective Olefin Metathesis”
Organometallics, 2018, 37 (7), pp 1219–1219
DOI: 10.1021/acs.organomet.7b00556
Nickel, Ruthenium, and Rhodium NCN-Pincer Complexes Featuring a Six-Membered N-Heterocyclic Carbene Central Moiety and Pyridyl Pendant Arms
Organometallics, 2018, 37 (7), pp 1123–1132
DOI: 10.1021/acs.organomet.8b00022
Synthesis and Catalytic Activity of (3,4-Diphenylcyclopentadienone)Iron Tricarbonyl Compounds in Transfer Hydrogenations and Dehydrogenations
Organometallics, 2018, 37 (7), pp 1133–1140
DOI: 10.1021/acs.organomet.8b00037
Considering a Possible Role for [H-Fe4N(CO)12]2– in Selective Electrocatalytic CO2 Reduction to Formate by [Fe4N(CO)12]−
Organometallics, 2018, 37 (7), pp 1087–1091
DOI: 10.1021/acs.organomet.7b00824