Discover the Most-Read Organic/Inorganic Chemistry Articles of July 2018

There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in July 2018, including research, reviews, perspectives and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.

Get free monthly updates on the most-read research in your field.

Read more of July’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Organic/Inorganic | Physical
***

ACS Catalysis

Self-Supported Earth-Abundant Nanoarrays as Efficient and Robust Electrocatalysts for Energy-Related Reactions
ACS Catal., 2018, 8 (7), pp 6707–6732
DOI: 10.1021/acscatal.8b01715

Low-Temperature CO2 Methanation over CeO2-Supported Ru Single Atoms, Nanoclusters, and Nanoparticles Competitively Tuned by Strong Metal–Support Interactions and H-Spillover Effect
ACS Catal., 2018, 8 (7), pp 6203–6215
DOI: 10.1021/acscatal.7b04469

Standards and Protocols for Data Acquisition and Reporting for Studies of the Electrochemical Reduction of Carbon Dioxide
ACS Catal., 2018, 8 (7), pp 6560–6570
DOI: 10.1021/acscatal.8b01340

Visible Light Mediated, Redox Neutral Remote 1,6-Difunctionalizations of Alkenes
ACS Catal., 2018, 8 (7), pp 6401–6406
DOI: 10.1021/acscatal.8b00707

Visible-Light-Mediated Efficient Metal-Free Catalyst for α-Oxygenation of Tertiary Amines to Amides
ACS Catal., 2018, 8 (7), pp 6659–6664
DOI: 10.1021/acscatal.8b01897

***

ACS Combinatorial Science

Photolabile Linkers for Solid-Phase Synthesis
ACS Comb. Sci., 2018, 20 (7), pp 377–399
DOI: 10.1021/acscombsci.8b00028

Molecular Docking Analysis and Biochemical Evaluation of Levansucrase from Sphingobium chungbukense DJ77
ACS Comb. Sci., 2018, 20 (7), pp 414–422
DOI: 10.1021/acscombsci.8b00002

Constrained Combinatorial Libraries of Gp2 Proteins Enhance Discovery of PD-L1 Binders
ACS Comb. Sci., 2018, 20 (7), pp 423–435
DOI: 10.1021/acscombsci.8b00010

Facile One-Pot Parallel Synthesis of 3-Amino-1,2,4-triazoles
ACS Comb. Sci.,2018, 20 (7), pp 461–466
DOI: 10.1021/acscombsci.8b00060

Combinatorial Nitrogen Gradients in Sputtered Thin Films
ACS Comb. Sci., 2018, 20 (7), pp 436–442
DOI: 10.1021/acscombsci.8b00035

***

ACS Medicinal Chemistry Letters

Drug Discovery: Collaborations between Contract Research Organizations and the Pharmaceutical Industry
ACS Med. Chem. Lett., 2018, 9 (7), pp 581–583
DOI: 10.1021/acsmedchemlett.8b00236

Chemical Strategies for Half-Life Extension of Biopharmaceuticals: Lipidation and Its Alternatives
ACS Med. Chem. Lett., 2018, 9 (7), pp 577–580
DOI: 10.1021/acsmedchemlett.8b00226

First-Time Disclosures of Clinical Candidates
ACS Med. Chem. Lett., 2018, 9 (7), pp 575–575
DOI: 10.1021/acsmedchemlett.8b00207

Emerging Utility of Fluorosulfate Chemical Probes
ACS Med. Chem. Lett., 2018, 9 (7), pp 584–586
DOI: 10.1021/acsmedchemlett.8b00276

MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology
ACS Med. Chem. Lett., 2018, 9 (7), pp 761–767
DOI: 10.1021/acsmedchemlett.8b00220

***

Bioconjugate Chemistry

Tuning the Diels–Alder Reaction for Bioconjugation to Maleimide Drug-Linkers
Bioconjugate Chem., 2018, 29 (7), pp 2406–2414
DOI: 10.1021/acs.bioconjchem.8b00320

Development of Anti-CD74 Antibody–Drug Conjugates to Target Glucocorticoids to Immune Cells
Bioconjugate Chem., 2018, 29 (7), pp 2357–2369
DOI: 10.1021/acs.bioconjchem.8b00312

Engineering Intravenously Administered Nanoparticles to Reduce Infusion Reaction and Stop Bleeding in a Large Animal Model of Trauma
Bioconjugate Chem., 2018, 29 (7), pp 2436–2447
DOI: 10.1021/acs.bioconjchem.8b00335

Photoprogramming Allostery in Human Serum Albumin
Open access through ACS AuthorChoice
Bioconjugate Chem., 2018, 29 (7), pp 2215–2224
DOI: 10.1021/acs.bioconjchem.8b00184

Mitochondria-Targeting Polydopamine Nanocomposites as Chemophotothermal Therapeutics for Cancer
Bioconjugate Chem., 2018, 29 (7), pp 2415–2425
DOI: 10.1021/acs.bioconjchem.8b00325

***

Inorganic Chemistry

Palladium Acetate Revisited: Unusual Ring-Current Effects, One-Electron Reduction, and Metal–Metal Bonding
Inorg. Chem., 2018, 57 (14), pp 8046–8049
DOI: 10.1021/acs.inorgchem.8b01369

Importance of Metal-Ion Exchange for the Biological Activity of Coordination Complexes of the Biomimetic Ligand N4Py
Open access through ACS AuthorChoice
Inorg. Chem., 2018, 57 (13), pp 7748–7756
DOI: 10.1021/acs.inorgchem.8b00714

Identifying the Rate-Limiting Elementary Steps of Nitrogen Fixation with Single-Site Fe Model Complexes
Open access through ACS Editors’ Choice
Inorg. Chem., 2018, 57 (14), pp 8499–8508
DOI: 10.1021/acs.inorgchem.8b01183

Theoretical Investigation of Plutonium-Based Single-Molecule Magnets
Inorg. Chem., 2018, 57 (14), pp 8098–8105
DOI: 10.1021/acs.inorgchem.8b00170

Photochemical Structural Transformation of a Linear 1D Coordination Polymer Impacts the Electrical Conductivity
Inorg. Chem., 2018, 57 (14), pp 8029–8032
DOI: 10.1021/acs.inorgchem.8b00833

***

Journal of Medicinal Chemistry

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design
J. Med. Chem., 2018, 61 (14), pp 5822–5880
DOI: 10.1021/acs.jmedchem.7b01788

Editorial on First-Time Disclosures of Clinical Candidates
J. Med. Chem., 2018, 61 (13), pp 5449–5449
DOI: 10.1021/acs.jmedchem.8b00739

Design, Synthesis, and Biological Evaluation of Pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-diones as Potent and Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors against L858R/T790M Resistance Mutation
J. Med. Chem., 2018, 61 (13), pp 5609–5622
DOI: 10.1021/acs.jmedchem.8b00346

Integrated Strategy for Lead Optimization Based on Fragment Growing: The Diversity-Oriented-Target-Focused-Synthesis Approach
J. Med. Chem., 2018, 61 (13), pp 5719–5732
DOI: 10.1021/acs.jmedchem.8b00653

Discovery of Potent and Centrally Active 6-Substituted 5-Fluoro-1,3-dihydro-oxazine β-Secretase (BACE1) Inhibitors via Active Conformation Stabilization
J. Med. Chem., 2018, 61 (13), pp 5525–5546
DOI: 10.1021/acs.jmedchem.8b00011

***

Journal of Natural Products

Swinhoeisterols from the South China Sea Sponge Theonella swinhoei
J. Nat. Prod., 2018, 81 (7), pp 1645–1650
DOI: 10.1021/acs.jnatprod.8b00281

Banksialactones and Banksiamarins: Isochromanones and Isocoumarins from an Australian Fungus, Aspergillus banksianus
J. Nat. Prod., 2018, 81 (7), pp 1517–1526
DOI: 10.1021/acs.jnatprod.7b00816

Cytochalasans Produced by the Coculture of Aspergillus flavipes and Chaetomium globosum
J. Nat. Prod., 2018, 81 (7), pp 1578–1587
DOI: 10.1021/acs.jnatprod.8b00110

Linfuranones B and C, Furanone-Containing Polyketides from a Plant-Associated Sphaerimonospora mesophila
J. Nat. Prod., 2018, 81 (7), pp 1561–1569
DOI: 10.1021/acs.jnatprod.8b00071

Abietane Diterpenoids from the Roots of Clerodendrum trichotomum and Their Nitric Oxide Inhibitory Activities
J. Nat. Prod., 2018, 81 (7), pp 1508–1516
DOI: 10.1021/acs.jnatprod.7b00814

***

Chemistry Takes a Bath: Reactions in Aqueous Media
This article is part of the Organic and Biocompatible Transformations in Aqueous Media special issue.
J. Org. Chem., 2018, 83 (14), pp 7319–7322
DOI: 10.1021/acs.joc.8b01412

Synthesis of Antibiotics and Related Molecules
This article is part of the Organic and Biocompatible Transformations in Aqueous Media special issue.
J. Org. Chem., 2018, 83 (13), pp 6826–6828
DOI: 10.1021/acs.joc.8b01330

Reconfirmation of “Art” in Organic Synthesis
This article is part of the Organic and Biocompatible Transformations in Aqueous Media special issue.
J. Org. Chem., 2018, 83 (13), pp 6825–6825
DOI: 10.1021/acs.joc.8b01234

Total Synthesis and Biological Mode of Action of WAP-8294A2: A Menaquinone-Targeting Antibiotic
Open access through ACS Editors’ Choice
This article is part of the Organic and Biocompatible Transformations in Aqueous Media special issue.
J. Org. Chem., 2018, 83 (13), pp 6924–6935
DOI: 10.1021/acs.joc.7b02318

Directed C–H Bond Oxidation of (+)-Pleuromutilin
This article is part of the Organic and Biocompatible Transformations in Aqueous Media special issue.
J. Org. Chem., 2018, 83 (13), pp 6843–6892
DOI: 10.1021/acs.joc.8b00462

***

Hybrid Mesoporous–Microporous Nanocarriers for Overcoming Multidrug Resistance by Sequential Drug Delivery
Mol. Pharmaceutics, 2018, 15 (7), pp 2503–2512
DOI: 10.1021/acs.molpharmaceut.7b01096

Probing the Interplay between Amorphous Solid Dispersion Stability and Polymer Functionality
Mol. Pharmaceutics, 2018, 15 (7), pp 2714–2720
DOI: 10.1021/acs.molpharmaceut.8b00219

Near-Infrared Activatable Phthalocyanine–Poly-L-Glutamic Acid Conjugate: Enhanced in Vivo Safety and Antitumor Efficacy toward an Effective Photodynamic Cancer Therapy
Mol. Pharmaceutics, 2018, 15 (7), pp 2594–2605
DOI: 10.1021/acs.molpharmaceut.8b00132

Entrapping of Nanoparticles in Yeast Cell Wall Microparticles for Macrophage-Targeted Oral Delivery of Cabazitaxel
Mol. Pharmaceutics, 2018, 15 (7), pp 2870–2882
DOI: 10.1021/acs.molpharmaceut.8b00357

Novel Milrinone Nanoformulation for Use in Cardiovascular Diseases: Preparation and in Vitro Characterization
Mol. Pharmaceutics, 2018, 15 (7), pp 2489–2502
DOI: 10.1021/acs.molpharmaceut.7b00360

***

Organic Letters

Adventures in Atropisomerism: Total Synthesis of a Complex Active Pharmaceutical Ingredient with Two Chirality Axes
Open access through ACS Editors’ Choice
Org. Lett., 2018, 20 (13), pp 3736–3740
DOI: 10.1021/acs.orglett.8b01218

Total Synthesis of (±)–Exotine B
Open access through ACS Editors’ Choice
Org. Lett., 2018, 20 (14), pp 4358–4361
DOI: 10.1021/acs.orglett.8b01817

Nickel-Catalyzed Direct C–H Trifluoromethylation of Free Anilines with Togni’s Reagent
Org. Lett., 2018, 20 (13), pp 3732–3735
DOI: 10.1021/acs.orglett.8b01216

TCFH–NMI: Direct Access to N-Acyl Imidazoliums for Challenging Amide Bond Formations
Open access through ACS Editors’ Choice
Org. Lett., 2018, 20 (14), pp 4218–4222
DOI: 10.1021/acs.orglett.8b01591

Diastereoselective Synthesis of the Hydroperoxide–Keto Form of (±)-Steenkrotin B
Org. Lett., 2018, 20 (13), pp 4153–4156
DOI: 10.1021/acs.orglett.8b01875

Organic Process Research & Development

Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2018, 22 (7), pp 747–754
DOI: 10.1021/acs.oprd.8b00212

Choosing the Right Coupling Reagent for Peptides: A Twenty-Five-Year Journey
Org. Process Res. Dev., 2018, 22 (7), pp 760–772
DOI: 10.1021/acs.oprd.8b00159

Improved Safety during Transfer of Pyrophoric tert-Butyllithium from Flasks with Protective Seals
Org. Process Res. Dev., 2018, 22 (7), pp 903–905
DOI: 10.1021/acs.oprd.8b00151

Solubility Correlations of Common Organic Solvents
Org. Process Res. Dev., 2018, 22 (7), pp 829–835
DOI: 10.1021/acs.oprd.8b00117

Development of a Scalable Synthesis of BMS-978587 Featuring a Stereospecific Suzuki Coupling of a Cyclopropane Carboxylic Acid
Org. Process Res. Dev., 2018, 22 (7), pp 888–897
DOI: 10.1021/acs.oprd.8b00171

***

Organometallics

Palladium-Catalyzed β-Arylation of Amide via Primary sp3C–H Activation
Organometallics, 2018, 37 (13), pp 2188–2192
DOI: 10.1021/acs.organomet.8b00325

A Carbon-Centered Hexagold(I) Cluster Supported by N-Heterocyclic Carbene Ligands
Organometallics, 2018, 37 (13), pp 2007–2009
DOI: 10.1021/acs.organomet.8b00291

Metal–Ligand Cooperation as Key in Formation of Dearomatized NiII–H Pincer Complexes and in Their Reactivity toward CO and CO2
Organometallics, 2018, 37 (14), pp 2217–2221
DOI: 10.1021/acs.organomet.8b00160

Cobalt POCOP Pincer Complexes via Ligand C–H Bond Activation with Co2(CO)8: Catalytic Activity for Hydrosilylation of Aldehydes in an Open vs a Closed System
Organometallics, 2018, 37 (13), pp 2147–2158
DOI: 10.1021/acs.organomet.8b00273

Chiral Bis(Phospholane) PCP Pincer Complexes: Synthesis, Structure, and Nickel-Catalyzed Asymmetric Phosphine Alkylation
Organometallics, 2018, 37 (13), pp 2159–2166
DOI: 10.1021/acs.organomet.8b00284