There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five […]
There are lots of different ways to look at the reach of an article. You can look at citations, Altmetric Attention Scores, awards, and more. One way to consider the influence of an article is just by looking at how many people chose to read it. To that end, we’ve compiled lists of the five most-read chemistry articles that appeared in each ACS Publications journal in August 2018, including research, reviews, perspectives, and editorial pieces. These lists were not chosen by the journal’s editors and should not be taken as a “best of” list, but as another perspective on where the chemistry community allocated their attention.
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Read more of August’s most-read articles: Analytical | Applied | Biological | Materials Science & Engineering | Multidisciplinary | Physical
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ACS Catalysis
Single-Atomic Cu with Multiple Oxygen Vacancies on Ceria for Electrocatalytic CO2 Reduction to CH4
ACS Catal., 2018, 8 (8), pp 7113–7119
DOI: 10.1021/acscatal.8b01014
Electrocatalytic C–H Activation
ACS Catal., 2018, 8 (8), pp 7086–7103
DOI: 10.1021/acscatal.8b01682
Approaches for Understanding and Controlling Interfacial Effects in Oxide-Supported Metal Catalysts
ACS Catal., 2018, 8 (8), pp 7368–7387
DOI: 10.1021/acscatal.8b02071
Gold-Catalyzed Oxidative Coupling of Terminal Alkynes and Borane Adducts: Efficient Synthesis of α-Boryl Ketones
Open access through ACS Editors’ Choice
ACS Catal., 2018, 8 (8), pp 7351–7355
DOI: 10.1021/acscatal.8b02052
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ACS Medicinal Chemistry Letters
Investigating the Behavior of Published PAINS Alerts Using a Pharmaceutical Company Data Set
Open access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2018, 9 (8), pp 792–796
DOI: 10.1021/acsmedchemlett.8b00097
C797S Resistance: The Undruggable EGFR Mutation in Non-Small Cell Lung Cancer?
ACS Med. Chem. Lett., 2018, 9 (8), pp 779–782
DOI: 10.1021/acsmedchemlett.8b00314
New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons
ACS Med. Chem. Lett., 2018, 9 (8), pp 803–808
DOI: 10.1021/acsmedchemlett.8b00106
Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody–Drug Conjugates
Open access through ACS Editors’ Choice
ACS Med. Chem. Lett., 2018, 9 (8), pp 838–842
DOI: 10.1021/acsmedchemlett.8b00254
Allosteric Modulators of the M4 Muscarinic Acetylcholine Receptor
ACS Med. Chem. Lett., 2018, 9 (8), pp 783–784
DOI: 10.1021/acsmedchemlett.8b00330
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Bioconjugate Chemistry
Covalent Modification of Biomolecules through Maleimide-Based Labeling Strategies
Bioconjugate Chem., 2018, 29 (8), pp 2497–2513
DOI: 10.1021/acs.bioconjchem.8b00252
“Tag and Modify” Protein Conjugation with Dynamic Covalent Chemistry
Bioconjugate Chem., 2018, 29 (8), pp 2665–2670
DOI: 10.1021/acs.bioconjchem.8b00358
Rational Design and Bioimaging Applications of Highly Specific “Turn-On” Fluorescent Probe for Hypochlorite
Bioconjugate Chem., 2018, 29 (8), pp 2838–2845
DOI: 10.1021/acs.bioconjchem.8b00430
Click Chemistry-Based DNA Labeling of Cells for Barcoding Applications
Bioconjugate Chem., 2018, 29 (8), pp 2846–2854
DOI: 10.1021/acs.bioconjchem.8b00435
Hyaluronic Acid Conjugates of TLR7/8 Agonists for Targeted Delivery to Secondary Lymphoid Tissue
Bioconjugate Chem., 2018, 29 (8), pp 2741–2754
DOI: 10.1021/acs.bioconjchem.8b00386
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Inorganic Chemistry
Through-Space Paramagnetic NMR Effects in Host-Guest Complexes: Potential Ruthenium(III) Metallodrugs with Macrocyclic Carriers
Open access through ACS AuthorChoice
Inorg. Chem., 2018, 57 (15), pp 8735–8747
DOI: 10.1021/acs.inorgchem.7b03233
Preface for the Forum on Applications of Metal Complexes with Ligand-Centered Radicals
This article is part of the Applications of Metal Complexes with Ligand-Centered Radicals special issue.
Inorg. Chem., 2018, 57 (16), pp 9577–9579
DOI: 10.1021/acs.inorgchem.8b02171
Enantioselective Separation over a Chiral Biphenol-Based Metal-Organic Framework
Inorg. Chem., 2018, 57 (15), pp 8697–8700
DOI: 10.1021/acs.inorgchem.8b00948
MOF-808: A Metal-Organic Framework with Intrinsic Peroxidase-Like Catalytic Activity at Neutral pH for Colorimetric Biosensing
Inorg. Chem., 2018, 57 (15), pp 9096–9104
DOI: 10.1021/acs.inorgchem.8b01097
Solvent-Modulated Emission Properties in a Superhydrophobic Oligo(p-phenyleneethynylene)-Based 3D Porous Supramolecular Framework
Inorg. Chem., 2018, 57 (15), pp 8693–8696
DOI: 10.1021/acs.inorgchem.8b00584
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Journal of Medicinal Chemistry
Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)
J. Med. Chem., 2018, 61 (15), pp 6501–6517
DOI: 10.1021/acs.jmedchem.8b00741
Lipophilic Efficiency as an Important Metric in Drug Design
J. Med. Chem., 2018, 61 (15), pp 6401–6420
DOI: 10.1021/acs.jmedchem.8b00077
Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations
J. Med. Chem., 2018, 61 (15), pp 6421–6467
DOI: 10.1021/acs.jmedchem.8b00180
Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression
J. Med. Chem., 2018, 61 (15), pp 6685–6704
DOI: 10.1021/acs.jmedchem.8b00506
Synthetic Approaches to New Drugs Approved During 2016
J. Med. Chem., 2018, 61 (16), pp 7004–7031
DOI: 10.1021/acs.jmedchem.8b00260
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Journal of Natural Products
An Alkaloid from Scorpion Venom: Chemical Structure and Synthesis
J. Nat. Prod., 2018, 81 (8), pp 1899–1904
DOI: 10.1021/acs.jnatprod.8b00527
A Bioactive Resveratrol Trimer from the Stem Bark of the Sri Lankan Endemic Plant Vateria copallifera
J. Nat. Prod., 2018, 81 (8), pp 1693–1700
DOI: 10.1021/acs.jnatprod.7b00892
Antitumor Activity of Diterpenoids from Jatropha gossypiifolia: Cell Cycle Arrest and Apoptosis-Inducing Activity in RKO Colon Cancer Cells
J. Nat. Prod., 2018, 81 (8), pp 1701–1710
DOI: 10.1021/acs.jnatprod.7b01036
Anti-inflammatory Potential of Flavonoids from the Aerial Parts of Corispermum marschallii
J. Nat. Prod., 2018, 81 (8), pp 1760–1768
DOI: 10.1021/acs.jnatprod.8b00152
Bioactive Sesquiterpenoids from the Peeled Stems of Syringa pinnatifolia
J. Nat. Prod., 2018, 81 (8), pp 1711–1720
DOI: 10.1021/acs.jnatprod.7b01071
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The Journal of Organic Chemistry
Addressing the Challenges of Structure Elucidation in Natural Products Possessing the Oxirane Moiety
Open access through ACS Editors’ Choice
J. Org. Chem., 2018, 83 (15), pp 8341–8352
DOI: 10.1021/acs.joc.8b0102
Base-Mediated Intramolecular Decarboxylative Synthesis of Alkylamines from Alkanoyloxycarbamates
Open access through ACS Editors’ Choice
J. Org. Chem., 2018, 83 (15), pp 8233–8240
DOI: 10.1021/acs.joc.8b00970
Advances in Decarboxylative Oxidative Coupling Reaction
J. Org. Chem., 2018, 83 (15), pp 7559–7565
DOI: 10.1021/acs.joc.8b01080
Catalyzed and Promoted Aliphatic Fluorination
J. Org. Chem., 2018, 83 (16), pp 8803–8814
DOI: 10.1021/acs.joc.8b00982
Stereocontrolled Synthesis of α-Xylofuranosides Using a Conformationally Restricted Donor
Open access through ACS AuthorChoice
J. Org. Chem., 2018, 83 (15), pp 7659–7671
DOI: 10.1021/acs.joc.8b00410
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Molecular Pharmaceutics
“Click” Chemistry for Medicine and Biology
This article is part of the Click Chemistry for Medicine and Biology special issue.
Mol. Pharmaceutics, 2018, 15 (8), pp 2891–2891
DOI: 10.1021/acs.molpharmaceut.8b00743
Interactions of Artefenomel (OZ439) with Milk during Digestion: Insights into Digestion-Driven Solubilization and Polymorphic Transformations
Open access through ACS AuthorChoice
Mol. Pharmaceutics, 2018, 15 (8), pp 3535–3544
DOI: 10.1021/acs.molpharmaceut.8b00541
Bacterial Cytological Profiling Reveals the Mechanism of Action of Anticancer Metal Complexes
Mol. Pharmaceutics, 2018, 15 (8), pp 3404–3416
DOI: 10.1021/acs.molpharmaceut.8b00407
Bioinspired Shielding Strategies for Nanoparticle Drug Delivery Applications
This article is part of the Click Chemistry for Medicine and Biology special issue.
Mol. Pharmaceutics, 2018, 15 (8), pp 2900–2909
DOI: 10.1021/acs.molpharmaceut.8b00292
Methionine-Decorated Near Infrared Fluorescent Probe for Prolonged Tumor Imaging
Mol. Pharmaceutics, 2018, 15 (8), pp 3167–3176
DOI: 10.1021/acs.molpharmaceut.8b00233
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Organic Letters
Diboron-Catalyzed Dehydrative Amidation of Aromatic Carboxylic Acids with Amines
Org. Lett., 2018, 20 (15), pp 4397–4400
DOI: 10.1021/acs.orglett.8b01480
Visible-Light-Initiated, Photocatalyst-Free Decarboxylative Coupling of Carboxylic Acids with N-Heterocycles
Org. Lett., 2018, 20 (15), pp 4686–4690
DOI: 10.1021/acs.orglett.8b02016
Enantioselective Total Synthesis of (−)-Misramine
Org. Lett., 2018, 20 (16), pp 5044–5047
DOI: 10.1021/acs.orglett.8b02198
A Family of Highly Fluorescent and Unsymmetric Bis(BF2) Chromophore Containing Both Pyrrole and N-Heteroarene Derivatives: BOPPY
Org. Lett., 2018, 20 (15), pp 4462–4466
DOI: 10.1021/acs.orglett.8b01752
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Organic Process Research & Development
Some Items of Interest to Process R&D Chemists and Engineers
Org. Process Res. Dev., 2018, 22 (8), pp 907–917
DOI: 10.1021/acs.oprd.8b00238
Development of an Efficient Manufacturing Process for Reversible Bruton’s Tyrosine Kinase Inhibitor GDC-0853
Org. Process Res. Dev., 2018, 22 (8), pp 978–990
DOI: 10.1021/acs.oprd.8b00134
Ring-Closing Metathesis in Pharmaceutical Development: Fundamentals, Applications, and Future Directions
Org. Process Res. Dev., 2018, 22 (8), pp 918–946
DOI: 10.1021/acs.oprd.8b00093
A Convergent Continuous Multistep Process for the Preparation of C4-Oxime-Substituted Thiazoles
Open access through ACS Editors’ Choice
Org. Process Res. Dev., 2018, 22 (8), pp 955–962
DOI: 10.1021/acs.oprd.8b00095
Advancing Flow Chemistry Portability: A Simplified Approach to Scaling Up Flow Chemistry
Org. Process Res. Dev. 2018, 22 (8), pp 1015–1021
DOI: 10.1021/acs.oprd.8b00063
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Organometallics
Dos and Don’ts: Thoughts on How To Respond to Reviewer Comments
Organometallics, 2018, 37 (16), pp 2655–2655
DOI: 10.1021/acs.organomet.8b00515
Bench-Stable Nickel Precatalysts with Heck-type Activation
Open access through ACS AuthorChoice
Organometallics, 2018, 37 (16), pp 2716–2722
DOI: 10.1021/acs.organomet.8b00351
Carbene Formation and Transfer at a Dinickel Active Site
Organometallics, 2018, 37 (15), pp 2437–2441
DOI: 10.1021/acs.organomet.8b00261
Synthesis, Characterization, and Reactivity of PCN Pincer Nickel Complexes
Organometallics, 2018, 37 (15), pp 2581–2593
DOI: 10.1021/acs.organomet.8b00333
Synthesis of Linear α-Olefin Distributions with Flexible Mean Molecular Weight by a Ti-Al-Ni Catalyst System
Organometallics, 2018, 37 (15), pp 2395–2398
DOI: 10.1021/acs.organomet.8b00428
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